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https://www.readbyqxmd.com/read/29661694/descriptive-epidemiology-of-parkinsonism-in-the-canton-of-geneva-switzerland
#1
Vanessa Fleury, Pauline Brindel, Nicolas Nicastro, Pierre R Burkhard
OBJECTIVES: A large descriptive cross-sectional population-based prevalence study as well as a retrospective incidence study were undertaken to ascertain the frequency of Parkinson's Disease (PD) and other types of degenerative and non-degenerative parkinsonism in the Canton of Geneva, Switzerland. METHODS: An extensive case-finding approach including records from public hospitals, private neurologists and nursing homes was utilized. All patients with a diagnosis of parkinsonism established between 2003 and 2012 were included...
April 9, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29659006/health-and-aging-policy-fellows-dementia-and-mental-health-policy-to-improve-lives-of-older-adults
#2
Pamela Z Cacchione, Kathleen M Pike, Brigitta Spaeth-Rublee, Harrold A Pincus
The Health and Aging Policy Fellows (HAPF) Program has, since its inception in 2008, provided health policy training and mentorship for 113 gerontological professionals across a wide range of disciplines and stages of careers. The fellows' shared passion is the effective engagement of policy levers to improve the lives of older adults. This article briefly describes the HAPF Program and provides a sample of policies with which fellows have been engaged related to dementia and late-life mental health. Approximately 20% of the fellows have specifically addressed one of these areas during their fellowship year...
April 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29658429/color-vision-impairment-differentiates-alzheimer-dementia-from-dementia-with-lewy-bodies
#3
Patrick M Flanigan, Mitra A Khosravi, James B Leverenz, Babak Tousi
OBJECTIVE: Dementia with Lewy bodies (DLB) is frequently misdiagnosed for Alzheimer dementia (AD), especially in its earlier stages. We characterized color vision impairment (CVI) in patients with DLB versus patients with AD to determine its usefulness in improving accuracy of early diagnosis. METHODS: We retrospectively reviewed charts of patients with AD, DLB, and patients with mild cognitive impairment suspected to be in the prodromal phase of DLB (pro-DLB) or prodromal phase of AD (pro-AD)...
March 2018: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/29656837/long-term-care-status-in-centenarians-and-younger-cohorts-of-oldest-old-in-the-last-6-years-of-life-trajectories-and-potential-mechanisms
#4
Paul Gellert, Simon Eggert, Christine Zwillich, Stefan Hörter, Adelheid Kuhlmey, Dagmar Dräger
OBJECTIVES: A large proportion of the oldest old and centenarians live in long-term care facilities. Although there may be distinct care patterns in centenarians compared with other cohorts of oldest old, the exact development concerning prevalence, length of stay, and factors that are associated with long-term care status in the last years before death is unknown. DESIGN: Longitudinal analyses of health insurance data across 6 years before death. SETTING AND PARTICIPANTS: In all, 1398 institutionalized and noninstitutionalized oldest old [deceased at 80-89 (octogenarians), 90-99 (nonagenarians), or over 100 years of age (centenarians)] from Germany were included...
April 13, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29656727/outcomes-in-hospitalized-ischemic-stroke-patients-with-dementia-on-admission-a-population-based-cohort-study
#5
Charlotte Zerna, Mary P Lindsay, Jiming Fang, Richard H Swartz, Eric E Smith
BACKGROUND: Dementia prevalence is rising, and it will double in the next 20 years. This study sought to understand the prevalence of dementia in hospitalized patients with ischemic stroke, and its impact on outcomes. METHODS: Using the Canadian Institute of Health Information's (CIHI) Discharge Abstract Database (DAD), all acute ischemic stroke admissions from April 2003 to March 2015 in Canada (excluding Quebec) were analyzed. Concurrent dementia at the time of admission was assessed based on hospital diagnostic codes...
April 16, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29656189/quantitative-electroencephalography-as-a-marker-of-cognitive-fluctuations-in-dementia-with-lewy-bodies-and-an-aid-to-differential-diagnosis
#6
Myrto Stylianou, Nicholas Murphy, Luis R Peraza, Sara Graziadio, Ruth Cromarty, Alison Killen, John T O' Brien, Alan J Thomas, Fiona E N LeBeau, John-Paul Taylor
OBJECTIVE: We investigated for quantitative EEG (QEEG) differences between Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) patients and healthy controls, and for QEEG signatures of cognitive fluctuations (CFs) in DLB. METHODS: We analysed eyes-closed, resting state EEGs from 18 AD, 17 DLB and 17 PDD patients with mild dementia, and 21 age-matched controls. Measures included spectral power, dominant frequency (DF), frequency prevalence (FP), and temporal DF variability (DFV), within defined EEG frequency bands and cortical regions...
April 3, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29653278/psychometric-validation-of-the-korean-version-of-the-camberwell-assessment-of-need-for-the-elderly-cane-k-in-dementia
#7
Myonghwa Park, Sun Kyung Kim, Miri Jeong, Song Ja Lee, Seon Hwa Kim, Jinha Kim, Dong Young Lee
PURPOSE: The prevalence of dementia has increased rapidly with an aging Korean population. Compared to those without dementia, individuals with dementia have more and complex needs. In this study, the Korean version of the Camberwell Assessment of Need for the Elderly (CANE-K) was evaluated to determine its suitability for individuals with dementia in Korea. METHODS: The CANE-K was developed following linguistic validation. The reliability of the measurement was examined with Cronbach's alpha coefficient...
April 10, 2018: Asian Nursing Research
https://www.readbyqxmd.com/read/29651270/disparities-in-functional-outcome-after-intracerebral-hemorrhage-among-asians-and-pacific-islanders
#8
Kazuma Nakagawa, Sage L King, Todd B Seto, Marjorie K L M Mau
Background: Disparities in outcome after intracerebral hemorrhage (ICH) among Asians, Native Hawaiians, and other Pacific Islanders (NHOPI) have been inadequately studied. We sought to assess differences in functional outcome between Asians and NHOPI after ICH. Methods: A multiracial prospective cohort study of ICH patients was conducted from 2011 to 2016 at a tertiary center in Honolulu, HI, USA to assess racial disparities in outcome after ICH. Favorable outcome was defined as 3-month modified Rankin Scale (mRS) score ≤2...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29644989/the-palliative-care-in-dementia-context-health-professionals-point-of-view-about-advantages-and-resistances
#9
Sabina Zapponi, Maria Chiara Ascari, Erjona Feracaku, Silvia Masin, Paola Paglia, Roberta Petroccione, Ana Pinzaru, Chiara Foà, Giovanna Artioli, Leopoldo Sarli
BACKGROUND AND AIM: The 38/2010 law has expanded the provision of palliative care to patients with chronic-degenerative diseases. The ISTAT data show that 60% of the dying population is suffering from these diseases and could, according to the literature review, benefit particularly from such treatments. This study investigates the point of view of healthcare professionals, working in the context of dementia, regarding the knowledge and application of palliative care in the field of dementia...
March 26, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29643322/metabolically-healthy-obesity-and-risk-of-leukoaraiosis-a-population-based-cross-sectional-study
#10
Takuro Okamura, Yoshitaka Hashimoto, Masahide Hamaguchi, Akihiro Ohbora, Takao Kojima, Michiaki Fukui
Metabolically healthy obese (MHO) individual is known to be defended from the metabolic complications of obesity. Leukoaraiosis, which is commonly detected on brain magnetic resonance imaging (MRI), is now recognized as a risk of stroke, dementia and death. However, the association between MHO and the prevalence of leukoaraiosis is unclear. In this cross-sectional study of 796 participants who received a medical examination program, we investigated the association between MHO and the prevalence of leukoaraiosis...
April 10, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29643258/prevalence-of-poststroke-neurocognitive-disorders-using-national-institute-of-neurological-disorders-and-stroke-canadian-stroke-network-vascog-criteria-vascular-behavioral-and-cognitive-disorders-and-optimized-criteria-of-cognitive-deficit
#11
Mélanie Barbay, Hervé Taillia, Claudine Nédélec-Ciceri, Flavie Bompaire, Camille Bonnin, Jérôme Varvat, Françoise Grangette, Momar Diouf, Emmanuel Wiener, Jean-Louis Mas, Martine Roussel, Olivier Godefroy
BACKGROUND AND PURPOSE: The prevalence of poststroke neurocognitive disorder (NCD) has yet to be accurately determined. The primary objective of the present study was to optimize operationalization of the criterion for NCD by using an external validity criterion. METHODS: The GRECOG-VASC cohort (Groupe de Réflexion pour l'Évaluation Cognitive Vasculaire) of 404 stroke patients with cerebral infarct (91.3%) or hemorrhage (18.7%) was assessed 6 months poststroke and 1003 healthy controls, with the National Institute of Neurological Disorders and Stroke-Canadian Stroke Network standardized battery...
April 11, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29628031/-definition-and-prevalence-of-mild-cognitive-impairment
#12
José Gutiérrez Rodríguez, Germán Guzmán Gutiérrez
Cognition is the ability that allows humans to carry out their lives without difficulty, resolving problems and situations, and to continue to learn and correctly process information from the environment for its subsequent retrieval and use. In persons with normal or physiological brain ageing, this ability is maintained throughout their lives. However, individuals with abnormal or pathological ageing could be affected by distinct degrees of impairment of higher brain functions. The term mild cognitive impairment (MCI) entered the lexicon in 1988 to describe a syndrome encompassing greater than expected cognitive impairment for the person's age and cultural environment...
June 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29626702/risk-factors-associated-with-dehydration-in-older-people-living-in-nursing-homes-scoping-review
#13
REVIEW
Olga Masot, Ana Lavedán, Carmen Nuin, Miguel A Escobar-Bravo, Jèssica Miranda, Teresa Botigué
BACKGROUND: Dehydration in the older people is a prevalent problem that is often associated with physiological changes, physical limitations and environmental conditions. OBJECTIVES: The scoping review was carried out to identify risk factors associated with dehydration in older people living in nursing homes. DESIGN: The revised scoping methodology framework of Arksey and O'Malley (2005) was applied. Study selection was carried out in accordance with Davis et al...
March 27, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29626553/development-of-a-risk-score-for-the-prediction-of-incident-dementia-in-older-adults-using-a-frailty-index-and-health-checkup-data-the-jages-longitudinal-study
#14
Huei-Ru Lin, Taishi Tsuji, Katsunori Kondo, Yuichi Imanaka
In Japan, the prevalence of dementia is expected to reach 4.7 million by 2025. This study aimed to develop a risk score for the prediction of incident dementia in community-dwelling older adults. In this longitudinal observational study, we used data from the Japan Gerontological Evaluation Study (JAGES) conducted in K City. We performed Cox regression analyses to develop three risk score models for the prediction of incident dementia in older adults using a frailty index and health checkup data. Analyses of the area under the receiver operating characteristic curve were conducted to compare the models' predictive abilities...
April 4, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29623063/amyloid-%C3%AE-plaques-in-clinical-alzheimer-s-disease-brain-incorporate-stable-isotope-tracer-in-vivo-and-exhibit-nanoscale-heterogeneity
#15
Norelle C Wildburger, Frank Gyngard, Christelle Guillermier, Bruce W Patterson, Donald Elbert, Kwasi G Mawuenyega, Theresa Schneider, Karen Green, Robyn Roth, Robert E Schmidt, Nigel J Cairns, Tammie L S Benzinger, Matthew L Steinhauser, Randall J Bateman
Alzheimer's disease (AD) is a neurodegenerative disorder with clinical manifestations of progressive memory decline and loss of executive function and language. AD affects an estimated 5.3 million Americans alone and is the most common form of age-related dementia with a rapidly growing prevalence among the aging population-those 65 years of age or older. AD is characterized by accumulation of aggregated amyloid-beta (Aβ) in the brain, which leads to one of the pathological hallmarks of AD-Aβ plaques. As a result, Aβ plaques have been extensively studied after being first described over a century ago...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29619930/neurological-and-psychiatric-comorbidity-in-patients-with-heart-failure-risk-and-prognosis
#16
Kasper Adelborg
Heart failure is a complex clinical syndrome and one of the leading causes of morbidity and mortality with a prevalence of 1%-2% of the adult population. The prognosis is poor with a 5-year mortality rate of 50%, which partly can be attributed to the presence of concomitant comorbidity, including neurological and psychiatric comorbidities. However, the prognostic impact of depression and the role of heart failure as a risk factor for dementia and stroke are not fully understood.
 Denmark is well-known for its unique health registries...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619173/fluoro-substituted-cyanine-for-reliable-in-vivo-labelling-of-amyloid-%C3%AE-oligomers-and-neuroprotection-against-amyloid-%C3%AE-induced-toxicity
#17
Yinhui Li, Di Xu, Anyang Sun, See-Lok Ho, Chung-Yan Poon, Hei-Nga Chan, Olivia T W Ng, Ken K L Yung, Hui Yan, Hung-Wing Li, Man Shing Wong
Alzheimer's disease (AD) is the most prevalent but still incurable neurodegenerative form of dementia. Early diagnosis and intervention are crucial for delaying the onset and progression of the disease. We herein report a novel fluoro-substituted cyanine, F-SLOH, which exhibits good Aβ oligomer selectivity with a high binding affinity, attributed to the synergistic effect of strong π-π stacking and intermolecular CH···O and CH···F interactions. The selectivity towards the Aβ oligomers in the brain was ascertained by in vitro labelling on tissue sections and in vivo labelling through the systemic administration of F-SLOH in 7 month APP/PS1 double transgenic (Tg) and APP/PS1/Tau triple Tg mouse models...
December 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29616708/strong-relationship-between-malnutrition-and-cognitive-frailty-in-the-singapore-longitudinal-ageing-studies-slas-1-and-slas-2
#18
L Chye, K Wei, M S Z Nyunt, Q Gao, S L Wee, T P Ng
BACKGROUND: Physical frailty is well known to be strongly associated with malnutrition, but the combined impact of physical frailty and cognitive impairment among non-demented older persons (cognitive frailty) on malnutrition prevalence is not well documented. DESIGN: Cross-sectional cohort study. SETTING AND PARTICIPANTS: Community-dwelling older Singaporeans aged ≥55y (n=5414) without dementia in the Singapore Longitudinal Ageing Study (SLAS-1 and SLAS-2)...
2018: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29615758/von-willebrand-factor-and-adamts13-activity-in-relation-to-risk-of-dementia-a-population-based-study
#19
Frank J Wolters, Johan Boender, Paul S de Vries, Michelle A Sonneveld, Peter J Koudstaal, Moniek P de Maat, Oscar H Franco, M Kamran Ikram, Frank W Leebeek, M Arfan Ikram
Low ADAMTS13 activity is associated with an increased risk of cardiovascular disease, which is generally attributed to its proteolytic effects on Von Willebrand factor (VWF). Cardiovascular health is an important determinant of cognitive decline, but the association of either VWF or ADAMTS13 with risk of dementia is unknown. Between 1997-2002, we measured VWF antigen and ADAMTS13 activity in 6055 participants of the population-based Rotterdam Study (mean age 69.3 years, 57.2% women). At baseline, 85 participants had dementia, and during 15 years of follow-up 821 developed dementia...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29614672/our-tau-tales-from-normal-to-pathological-behavior
#20
Alejandra D Alonso, Leah S Cohen
The microtubule associated protein tau in a hyperphosphorylated form was identified as the building block of the filamentous aggregates found in the neurons of Alzheimer's disease (AD) patients. In the abnormal state, hyperphosphorylated tau from AD brains (AD P-tau) was unable to promote microtubule assembly and more importantly, it could inhibit the normal activity of tau and other MAPs. AD P-tau was able to disrupt preformed microtubules and, by binding to normal tau, turn the latter into an AD P-tau like molecule...
March 24, 2018: Journal of Alzheimer's Disease: JAD
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