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Radical hysterectomy

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https://www.readbyqxmd.com/read/28108027/a-postoperative-scoring-system-for-distant-recurrence-in-node-positive-cervical-cancer-patients-after-radical-hysterectomy-and-pelvic-lymph-node-dissection-with-para-aortic-lymph-node-sampling-or-dissection
#1
Young-Jae Lee, Dae-Yeon Kim, Shin-Wha Lee, Jeong-Yeol Park, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
OBJECTIVE: To identify risk factors for distant recurrence in node-positive cervical cancer patients who underwent radical hysterectomy and pelvic lymph node dissection (PLND) with para-aortic lymph node sampling (PALNS) or para-aortic lymph node dissection (PALND). METHODS: A total of 299 patients in whom lymph node metastasis was confirmed after radical surgery at Asan Medical Center for stage IA2 to IIB cervical cancer from February 2001 to December 2012 were identified...
January 17, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28104497/robot-assisted-surgery-in-gynecologic-cancers
#2
REVIEW
V Zanagnolo, A Garbi, M T Achilarre, L Minig
Robotic-assisted surgery is a technological advancement that facilitates the application of minimally invasive techniques for complex operations in gynecological oncology. The objective of this article is to review the literature regarding the role of robotic-assisted surgery to treat women with gynecologic cancers. The majority of publications on robotic surgery are still retrospective or descriptive in nature, however, the data for managing patients with a robotic assisted approach shows comparable, and at times an improved outcomes compared to both laparoscopy (2D) and laparotomy approaches...
January 16, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28101349/clear-cell-carcinoma-of-the-lower-uterine-segment-a-case-report
#3
Yusuke Matoba, Iori Kisu, Keiko Saotome, Motoko Katayama, Makiko Taniguchi, Yumiko Miura, Taeko Goto, Nobumaru Hirao
Uterine carcinoma of the lower uterine segment (LUS) is a rare tumor that accounts for 3-3.5% of cases of uterine malignant cancer. The tumor arises from the lower region of the uterine body through the upper region of the cervix. The present study reported a case of clear cell carcinoma that originated from the LUS. A 50-year-old woman visited a local hospital due to irregular vaginal bleeding. She was suspected to have a uterine tumor and was referred to Tachikawa Hospital (Tokyo, Japan). Transvaginal ultrasound and magnetic resonance imaging revealed a uterine tumor from the lower region of the uterine body through the upper region of the cervix...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28096638/coexisting-genital-malignancies-with-tuberculosis-a-case-series-with-review-of-literature
#4
Avantika Gupta, Sangeeta Gupta, Usha Manaktala, Nita Khurana
OBJECTIVE: To study a case series of genital malignancies coexisting with genital tuberculosis. MATERIALS AND METHODS: A series of three cases with known genital malignancies were found to have coexisting genital tuberculosis on subsequent workup. RESULTS: First case was a 45 years old lady who underwent staging laparotomy for ovarian cancer. On histopathology examination, there was coexisting tuberculosis with papillary serous carcinoma. Second case was 53 years old postmenopausal lady who underwent extrafascial hysterectomy along with pelvic lymph node dissection...
October 2016: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28095994/outcome-of-early-stage-cervical-cancer-patients-treated-according-to-a-radiosurgical-approach-clinical-results-and-prognostic-factors
#5
Escande Alexandre, Gouy Sebastien, Mazeron Renaud, Bentivegna Enrica, Bacorro Warren, Maroun Pierre, Schernberg Antoine, Oberlander Anne-Sophie, Dumas Isabelle, Genestie Catherine, Deutsch Eric, Morice Philippe, Haie-Meder Christine, Chargari Cyrus
OBJECTIVE: To report clinical results of a multimodal strategy based on preoperative brachytherapy followed with surgery in early stage cervical cancer. MATERIALS/METHODS: The outcome of consecutive patients receiving brachytherapy in our Institution for an early stage IB1-IIA1 invasive cervical cancer with risk factors (lymphovascular embols and/or tumor >2cm) between 2000 and 2013 was analyzed. The treatment consisted of preoperative low dose or pulse dose-rate utero-vaginal brachytherapy followed, 6-8weeks later, by a radical hysterectomy/bilateral salpingo-oophorectomy plus pelvic±para-aortic lymph node dissection...
January 14, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28094020/the-wertheim-hysterectomy-development-modifications-and-impact-in-the-present-day
#6
Alexa L Swailes, Allison Gockley, Rébécca Phaëton, Joshua P Kesterson
Ernst Wertheim was a pioneer in the history of the surgical treatment of cervical cancer. His English-language manuscript "The extended abdominal operation for carcinoma uteri (based on 500 operative cases)," which was published in 1912, detailed his standardization of the radical hysterectomy and formed the basis of the current treatment for early stage cervical cancer. We contextualize the Wertheim hysterectomy, emphasizing medical advances that allowed for its development and subsequent modification. We then discuss modifications to the originally proposed procedure, including a maximally extended parametrical resection pioneered by Takayama, and the addition of the Taussig en bloc lymph node dissection by Meigs, both of which afforded an improved mortality profile due to decreased disease recurrence...
January 13, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28088221/role-of-pelvic-and-para-aortic-lymphadenectomy-in-abandoned-radical-hysterectomy-in-cervical-cancer
#7
Salim Abraham Barquet-Muñoz, Gabriel Jaime Rendón-Pereira, Denise Acuña-González, Monica Vanessa Heymann Peñate, Luis Alonso Herrera-Montalvo, Lenny Nadia Gallardo-Alvarado, David Francisco Cantú-de León, René Pareja
BACKGROUND: Cervical cancer (CC) occupies fourth place in cancer incidence and mortality worldwide in women, with 560,505 new cases and 284,923 deaths per year. Approximately, nine of every ten (87%) take place in developing countries. When a macroscopic nodal involvement is discovered during a radical hysterectomy (RH), there is controversy in the literature between resect macroscopic lymph node compromise or abandonment of the surgery and sending the patient for standard chemo-radiotherapy treatment...
January 14, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28057354/neuroendrocrine-tumors-of-the-uterine-cervix-a-therapeutic-challenge-for-gynecologic-oncologists
#8
REVIEW
Gadducci Angiolo, Carinelli Silvestro, Aletti Giovanni
Neuroendocrine tumors (NETs) are aggressive diseases developing from neuroendocrine cells that most frequently involve the gastro-entero-pancreatic tract and the lung, but more rarely are found in almost all body tissues. Limited biological and clinical data are currently available for NETs in uncommon sites, such as female genital tract. NETs represent 0.9% to 1.5% of the tumors of the uterine cervix. They are more likely to have lymph-vascular space invasion and lymph node involvement, and to develop local and distant relapses when compared with the mostly common cervical squamous cell carcinomas or adenocarcinomas...
January 2, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28039643/respiratory-dynamics-and-dead-space-to-tidal-volume-ratio-of-volume-controlled-versus-pressure-controlled-ventilation-during-prolonged-gynecological-laparoscopic-surgery
#9
Ming Lian, Xiao Zhao, Hong Wang, Lianhua Chen, Shitong Li
BACKGROUND: Laparoscopic operations have become longer and more complex and applied to a broader patient population in the last decades. Prolonged gynecological laparoscopic surgeries require prolonged pneumoperitoneum and Trendelenburg position, which can influence respiratory dynamics and other measurements of pulmonary function. We investigated the differences between volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) and tried to determine the more efficient ventilation mode during prolonged pneumoperitoneum in gynecological laparoscopy...
December 30, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/28038476/single-site-robotic-radical-hysterectomy-and-sentinel-lymphnode-biopsy-in-cervical-cancer-a-case-report
#10
Alexandre Silva E Silva, Rodrigo Pinto Fernandes, Marcia Pereira de Araujo, João Paulo Mancusi de Carvalho, Filomena Marino Carvalho, Giovani Mastrantônio Favero, Jesus Paula Carvalho
Robotic surgeries for cervical cancer have several advantages compared with laparotomic or laparoscopic surgeries. Robotic single-site surgery has many advantages compared with the multiport approach, but its safety and feasibility are not established in radical oncologic surgeries. We report a case of a Federation of Gynecology and Obstetrics (FIGO) stage IB1 cervical carcinoma whose radical hysterectomy, sentinel lymph node mapping, and lymph node dissection were entirely performed by robotic single-site approach...
December 30, 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28011096/minimally-invasive-radical-hysterectomy-for-cervical-cancer-is-associated-with-reduced-morbidity-and-similar-survival-outcomes-compared-with-laparotomy
#11
Elisabeth Diver, Emily Hinchcliff, Allison Gockley, Alexander Melamed, Leah Contrino, Sarah Feldman, Whitfield Growdon
STUDY OBJECTIVE: In cervical cancer, there are limited randomized trials to indicate whether patient outcomes are equivalent after radical hysterectomy (RH) via minimally invasive (MIS) or traditional laparotomy (XL) approach. The aim of this study was to assess patient outcomes of women with cervical cancer undergoing upfront RH at two large academic institutions to determine if mode of surgery affects patient outcomes. DESIGN: A retrospective cohort study Design classification: Canadian Task Force Classification II-1 SETTING: Two academic medical institutions in the United States from 2000 to 2013 PATIENTS: Women undergoing upfront RH for cervical cancer INTERVENTION: Minimally invasive techniques (laparoscopic and robotic) for RH, as compared with XL MEASUREMENTS AND MAIN RESULTS: 383 women met eligibility requirements...
December 20, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28007583/towards-a-privacy-preserving-cohort-discovery-framework-for-clinical-research-networks
#12
Jiawei Yuan, Bradley Malin, François Modave, Yi Guo, William R Hogan, Elizabeth Shenkman, Jiang Bian
BACKGROUND: The last few years have witnessed an increasing number of clinical research networks (CRNs) focused on building large collections of data from electronic health records (EHRs), claims, and patient-reported outcomes (PROs). Many of these CRNs provide a service for the discovery of research cohorts with various health conditions, which is especially useful for rare diseases. Supporting patient privacy can enhance the scalability and efficiency of such processes; however, current practice mainly relies on policy, such as guidelines defined in the Health Insurance Portability and Accountability Act (HIPAA), which are insufficient for CRNs (e...
December 19, 2016: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28003568/hemoperitoneum-due-to-breaking-uterine-adenosarcoma-located-in-the-omentum-report-of-a-case
#13
Pasquale Cianci, Nicola Tartaglia, Amedeo Altamura, Alberto Fersini, Francesca Sanguedolce, Antonio Ambrosi, Vincenzo Neri
AIM: We report an unusual case of broken adenosarcoma located in the omentum that has procured a clinical situation of acute abdomen in a patient. CASE REPORT: A 79 year-old woman went to the emergency room for growing abdominal pain and then transferred to our department. In previous years the patient had removed endo-cervical and endometrial fibro-glandular polyps and subsequently to a total laparoscopic hysterectomy with bilateral oophorectomy was performed for another endometrial fibroglandular polyp; other vaginal recurrences were then removed...
December 20, 2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28002534/vaginal-epithelioid-angiosarcoma-a-rare-case
#14
Elvira Brătilă, Oana Maria Ionescu, Costin Berceanu, Ciprian Andrei Coroleucă, Carmen Maria Ardeleanu, Claudia MehedinŢu
Epithelioid angiosarcoma of the vagina is a rare variant, easily misdiagnosed as other epithelial neoplasms. On Hematoxylin-Eosin-stained sections, the pathologist encounters sheets of large, mildly to moderately pleomorphic epithelioid cells, with abundant eosinophilic cytoplasm, vesicular nuclei, and prominent nucleoli. We report the case of a 22-year-old woman initially diagnosed with condiloma-like tumor of the left vaginal wall, which turned out positive at immunostaining for epithelioid angiosarcoma. In her case, after the failure of chemotherapy in controlling the relapse of the disease, the only treatment option was radical hysterectomy with bilateral salpingo-oophorectomy...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27987021/impaired-contraction-and-decreased-detrusor-innervation-in-a-female-rat-model-of-pelvic-neuropraxia
#15
Johanna L Hannan, Shelby A Powers, Vinson M Wang, Fabio Castiglione, Petter Hedlund, Trinity J Bivalacqua
INTRODUCTION AND HYPOTHESIS: Bilateral pelvic nerve injury (BPNI) is a model of post-radical hysterectomy neuropraxia, a common sequela. This study assessed the time course of changes to detrusor autonomic innervation, smooth muscle (SM) content and cholinergic-mediated contraction post-BPNI. METHODS: Female Sprague-Dawley rats underwent BPNI or sham surgery and were evaluated 3, 7, 14, and 30 days post-BPNI (n = 8/group). Electrical field-stimulated (EFS) and carbachol-induced contractions were measured...
December 16, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27984376/long-term-morbidity-and-quality-of-life-in-cervical-cancer-survivors-a-multicenter-comparison-between-surgery-and-radiotherapy-as-primary-treatment
#16
Marloes Derks, Luc R C W van Lonkhuijzen, Rinske M Bakker, Anne M Stiggelbout, Cornelis D de Kroon, Henrike Westerveld, Jan Paul W R Roovers, Gemma G Kenter, Moniek M Ter Kuile
OBJECTIVE: To compare long-term morbidity and quality of life after primary surgery or primary radiotherapy for stage IB/II cervical cancer. METHODS: A cross-sectional study was performed. Patients treated for stage IB/II cervical cancer between 2000 and 2010 were approached to participate. Primary treatment consisted of radical hysterectomy with pelvic lymphadenectomy (RHL), for selected cases followed by adjuvant (chemo-)radiotherapy, or primary (chemo)radiotherapy (PRT)...
December 15, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27930529/effects-of-propofol-and-sevoflurane-on-perioperative-immune-response-in-patients-undergoing-laparoscopic-radical-hysterectomy-for-cervical-cancer
#17
Songtao Liu, Xinyu Gu, Lijiao Zhu, Guannan Wu, Hai Zhou, Yan Song, Congyou Wu
The aim of this study is to compare the effects of propofol and sevoflurane anesthesia on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer.Sixty patients with cervical cancer scheduled for elective laparoscopic radical hysterectomy under general anesthesia were randomized into 2 groups. TIVA group received propofol induction and maintenance and SEVO group received sevoflurane induction and maintenance. Blood samples were collected at 30 min before induction (T0); the end of the operation (T1); and 24 h (T2), 48 h (T3), and 72 h (T4) after operation...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27926501/abdominal-radical-trachelectomy-guided-by-sentinel-lymph-node-biopsy-for-stage-ib1-cervical-cancer-with-tumors-2-cm
#18
Xiangyun Deng, Ying Zhang, Dapeng Li, Xiaoling Zhang, Hui Guo, Fei Wang, Xiugui Sheng
Accuracy of prediction of pelvic lymph node status using sentinel lymph node biopsy (SLNB), and outcomes of SLNB-guided abdominal radical trachelectomy (ART) were assessed. Patients with stage IB1 (Figure 2009) cervical cancer and with tumors >2 cm were enrolled. Prior to fertility-sparing surgery 99mTc-labeled phytate was administered. SLNs were intraoperatively identified, excised, and assessed using fast-frozen sections. Systematic bilateral pelvic lymphadenectomy with or without para-aortic lymphadenectomy was subsequently undertaken...
December 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27912770/endometriosis-associated-clear-cell-carcinoma-arising-in-caesarean-section-scar-a-case-report-and-review-of-the-literature
#19
Gabriella Ferrandina, Eleonora Palluzzi, Francesco Fanfani, Stefano Gentileschi, Anna Lia Valentini, Maria Vittoria Mattoli, Ilaria Pennacchia, Giovanni Scambia, Gianfranco Zannoni
BACKGROUND: Malignant transformation has been reported in approximately 1% of the endometriosis cases; herein, we report a case of clear cell endometrial carcinoma arising from endometriosis foci located within a caesarean section scar. CASE PRESENTATION: In November 2014, a Caucasian, 44-year-old woman was transferred to our institution because of severe respiratory failure due to massive lung embolism and rapid enlargement of a subcutaneous suprapubic mass. Abdomino-pelvic magnetic resonance showed a 10...
December 3, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27897021/-sexual-morbidity-of-cervical-carcinoma-survivors
#20
P Herboltová, A Roztočil
OBJECTIVE: We are aware that patients with cervical carcinoma in the Czech Republic are poorly informed about sexual aspects of their therapy and there is also very poor attention paid to this problem in the Czech literature. Therefore we decided to evaluate the situation in a group of patients from our department using our own questionaire. We compared our results with contemporary world literature. DESIGN: Questionnaire survey, comparison with world literature...
2016: Ceská Gynekologie
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