Sebastian Peters, Sabrina Kuespert, Eva Wirkert, Rosmarie Heydn, Benjamin Jurek, Siw Johannesen, Ohnmar Hsam, Sven Korte, Florian Timo Ludwig, Lars Mecklenburg, Heike Mrowetz, Barbara Altendorfer, Rodolphe Poupardin, Susanne Petri, Dietmar R Thal, Andreas Hermann, Jochen H Weishaupt, Joachim Weis, Inci Sevval Aksoylu, Sebastian A Lewandowski, Ludwig Aigner, Tim-Henrik Bruun, Ulrich Bogdahn
Adult neurogenesis is a target for brain rejuvenation as well as regeneration in aging and disease. Numerous approaches showed efficacy to elevate neurogenesis in rodents, yet translation into therapies has not been achieved. Here, we introduce a novel human TGFβ-RII (Transforming Growth Factor-Receptor Type II) specific LNA-antisense oligonucleotide ("locked nucleotide acid"-"NVP-13"), which reduces TGFβ-RII expression and downstream receptor signaling in human neuronal precursor cells (ReNcell CX® cells) in vitro...
July 2021: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics