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Frank Pega, Giorgi Kvizhinadze, Tony Blakely, June Atkinson, Nick Wilson
BACKGROUND: This study aimed to improve on previous modelling work to determine the health gain, cost-utility and health equity impacts from home safety assessment and modification (HSAM) for reducing injurious falls in older people. METHODS: The model was a Markov macrosimulation one that estimated quality-adjusted life-years (QALYs) gained. The setting was a country with detailed epidemiological and cost data (New Zealand (NZ)) for 2011. A health system perspective was taken and a discount rate of 3% was used (for both health gain and costs)...
May 24, 2016: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
Qichi Hu, Julia Laskin
The secondary structures of multiply charged ubiquitin ions soft-landed onto self-assembled monolayer (SAM) surfaces were studied using in situ infrared reflection-absorption spectroscopy (IRRAS). Two charge states of ubiquitin, 5+ and 13+, were mass selected separately from a mixture of different charge states produced by electrospray ionization (ESI). The low 5+ charge state represents a nativelike folded state of ubiquitin, while the high 13+ charge state assumes an extended, almost linear conformation. Each of the two charge states was soft-landed onto a CH3- and COOH-terminated SAM of alkanethiols on gold (HSAM and COOH-SAM)...
June 9, 2016: Journal of Physical Chemistry. B
Aurora K R LePort, Shauna M Stark, James L McGaugh, Craig E L Stark
Highly Superior Autobiographical Memory (HSAM) is characterised as the ability to accurately recall an exceptional number of experiences and their associated dates from events occurring throughout much of one's lifetime. The source of this ability has only begun to be explored. The present study explores whether other enhanced cognitive processes may be critical influences underlying HSAM abilities. We investigated whether enhanced abilities in the domains of verbal fluency, attention/inhibition, executive functioning, mnemonic discrimination, perception, visual working memory, or the processing of and memory for emotional details might contribute critically to HSAM...
March 16, 2016: Memory
Lawrence Patihis
Highly superior autobiographical memory (HSAM) is a recently identified ability that has been difficult to explain with existing memory science. The present study measured HSAM participants' and age/gender-matched controls' on a number of behavioural measures to test three main hypotheses: imaginative absorption, emotional arousal, and sleep. HSAM participants were significantly higher than controls on the dispositions absorption and fantasy proneness. These two dispositions also were associated with a measure of HSAM ability within the hyperthymesia participants...
August 2016: Memory
Daniela J Palombo, Claude Alain, Hedvig Söderlund, Wayne Khuu, Brian Levine
Recollection of previously experienced events is a key element of human memory that entails recovery of spatial, perceptual, and mental state details. While deficits in this capacity in association with brain disease have serious functional consequences, little is known about individual differences in autobiographical memory (AM) in healthy individuals. Recently, healthy adults with highly superior autobiographical capacities have been identified (e.g., LePort, A.K., Mattfeld, A.T., Dickinson-Anson, H., Fallon, J...
June 2015: Neuropsychologia
Hsiao-Chiang Ni, Chia-Yu Yu, Su-Jung Chen, Liang-Cheng Chen, Chien-Hong Lin, Wan-Chi Lee, Cheng-Hui Chuang, Chung-Li Ho, Chih-Hsien Chang, Te-Wei Lee
OBJECTIVE: The present study relates to a method for preparing 188Re-labeled human serum albumin microspheres (HSAM) by 188Re(I)-tricarbonyl ion(188Re(OH2)3(CO)3)+). This radioactive particle can be subjected to radioembolization for liver tumor. METHODS: The particle sizes and conformations of HSA microspheres were analyzed by Particle sizes-Malvern mastersizer and Scanning Electron Microscope (SEM). For preparing 188Re(I)-tricarbonyl ion, the 188ReO4- was eluted from a 188W/188Re generator with saline...
May 2015: Applied Radiation and Isotopes
Carmen-Marinela Mihailescu, Dana Stan, Rodica Iosub, Carmen Moldovan, Mihaela Savin
The fabrication of a capacitive interdigitated immunosensor (CID) based on a mixed self-assembled monolayer (mSAM) film for the direct detection of heart fatty-acid binding protein (h-FABP) without any labeling is described. The capacitance changes of mSAMs vs. homogenous ordered self-assembled monolayers (hSAMs) on gold work electrodes/covalently bonded antibodies/buffered medium are utilized for monitoring the specific antibody-antigen interaction. Capacitance measurements in the absence and presence of Faradaic currents were performed...
January 2015: Talanta
Juliane Schelhorn, Judith Ertle, Joerg F Schlaak, Stefan Mueller, Andreas Bockisch, Thomas Schlosser, Thomas Lauenstein
Selective internal radiation therapy (SIRT) using 90-yttrium is a local therapy for unresectable liver malignancies. Non-targeted 90-yttrium diversion via a patent hepatic falciform artery (HFA) is seen as risk for periprocedural complications. Therefore, this study aimed to evaluate the impact of a patent HFA on SIRT. 606 patients with SIRT between 2006 and 2012 were evaluated retrospectively. SIRT preparation was performed by digital subtraction angiography including (99m)Tc-HSAM administration and subsequent SPECT/CT...
2014: SpringerPlus
Hitomi Hosaka, Risa Haruki, Kana Yamada, Christoph Böttcher, Teruyuki Komatsu
A covalent core-shell structured protein cluster composed of hemoglobin (Hb) at the center and human serum albumins (HSA) at the periphery, Hb-HSAm, is an artificial O2 carrier that can function as a red blood cell substitute. Here we described the preparation of a novel Hb-HSA3 cluster with antioxidant activities and its O2 complex stable in aqueous H2O2 solution. We used an approach of incorporating a Pt nanoparticle (PtNP) into the exterior HSA unit of the cluster. A citrate reduced PtNP (1.8 nm diameter) was bound tightly within the cleft of free HSA with a binding constant (K) of 1...
2014: PloS One
Jiantang Zhu, Pengchao Hao, Guanxing Chen, Caixia Han, Xiaohui Li, Friedrich J Zeller, Sai L K Hsam, Yingkao Hu, Yueming Yan
BACKGROUND: The endoplasmic reticulum chaperone binding protein (BiP) is an important functional protein, which is involved in protein synthesis, folding assembly, and secretion. In order to study the role of BiP in the process of wheat seed development, we cloned three BiP homologous cDNA sequences in bread wheat (Triticum aestivum), completed by rapid amplification of cDNA ends (RACE), and examined the expression of wheat BiP in wheat tissues, particularly the relationship between BiP expression and the subunit types of HMW-GS using near-isogenic lines (NILs) of HMW-GS silencing, and under abiotic stress...
2014: BMC Plant Biology
N B Ohnmar Hsam, Krzysztof Kowalczyk, Friedrich J Zeller, Sai L K Hsam
Genetic characterization of a new powdery mildew resistance gene in a common wheat line ATRI3004/79 was conducted by employing a set of Blumeria graminis tritici isolates collected from Europe. Monosomic analysis revealed that a major resistance gene is located on chromosome 1A. Allelism tests of the F2 and F3 populations with other previously known genes on 1A showed that the resistance gene in ATRI3004/79 is closely linked to the Pm3d resistance gene in the German cultivar Syros, whereas it segregated independently from Pm25...
February 2015: Journal of Applied Genetics
J Schelhorn, J Theysohn, J Ertle, J F Schlaak, S Mueller, A Bockisch, T Lauenstein
AIM: To assess the effect of gastroduodenal artery (GDA) occlusion prior to selective internal radiation therapy (SIRT) with regards to arterial hepato-intestinal collateralization (HIC). MATERIALS AND METHODS: Six hundred and six patients were scheduled for SIRT between 2006 and 2012 at University Hospital Essen, Germany. Digital subtraction angiography (DSA) followed by administration of 99m-technetium labelled human serum albumin microspheres ((99m)Tc-HSAM) and single-photon emission computed tomography combined with computed tomography (SPECT/CT) was initially performed...
May 2014: Clinical Radiology
Sai L K Hsam, Volker Mohler, Friedrich J Zeller
The genetics of resistance to powdery mildew caused by Blumeria graminis f. sp. avenae of four cultivated oats was studied using monosomic analysis. Cultivar 'Bruno' carries a gene (Pm6) that shows a recessive mode of inheritance and is located on chromosome 10D. Cultivar 'Jumbo' possesses a dominant resistance gene (Pm1) on chromosome 1C. In cultivar 'Rollo', in addition to the gene Pm3 on chromosome 17A, a second dominant resistance gene (Pm8) was identified and assigned to chromosome 4C. In breeding line APR 122, resistance was conditioned by a dominant resistance gene (Pm7) that was allocated to chromosome 13A...
May 2014: Journal of Applied Genetics
Saminathan Subburaj, Guanxing Chen, Caixia Han, Dongwen Lv, Xiaohui Li, Friedrich J Zeller, Sai L K Hsam, Yueming Yan
Brachypodium distachyon, a small wild grass within the Pooideae family, is a new model organism for exploring the functional genomics of cereal crops. It was shown to have close relationships to wheat, barley and rice. Here, we describe the molecular characterisation and evolutionary relationships of high molecular weight glutenin subunits (HMW-GS) genes from B. distachyon. Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE), high performance capillary electrophoresis (HPCE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analyses demonstrated that there was no HMW-GS expression in the Brachypodium grains due to the silencing of their encoding genes...
February 2014: Journal of Applied Genetics
S L Hsam, F J Zeller
The relationships of Agropyron intermedium chromosomes in two wheat-Agropyron addition series were determined. Chromosome pairing behaviour revealed that the alien chromosome in lines TAF-2 and L7 of 'Vilmorin'-A. intermedium set are homologous to the alien chromosomes in lines P and C of the 'Caribo'-A. intermedium set respectively. Localization of alcohol dehydrogenase isozyme genes in 'Vilmorin'-Agropyron addition line L4 and in 'Caribo'-Agropyron line O indicated relationships with wheat chromosomes of homoeologous group 4...
September 1982: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
S L Hsam, F J Zeller, W Huber
The 6-phosphogluconate dehydrogenase (6-PGD) zymogram phenotypes of wheat, rye and their aneuploid derivatives were determined. Two genes involved in the production of 6-PGD isozymes were located on chromosome arms CRL (4 RL) and FRL (6 RL) of "Imperial" rye. On the basis of differential interactions between wheat and rye chromosomes, evidence was obtained that genes located on chromosomes 6 A, 6 BL and 7 BL control 6-PGD isozyme activities in 'Chinese Spring' wheat. The wheat and rye 6-PGD zymogram phenotypes were indicative of homoeologous relationships between rye chromosome 6 RL to wheat chromosomes of group 6, and rye chromosome 4 RL to wheat chromosomes of group 7...
December 1982: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Lawrence Patihis, Steven J Frenda, Aurora K R LePort, Nicole Petersen, Rebecca M Nichols, Craig E L Stark, James L McGaugh, Elizabeth F Loftus
The recent identification of highly superior autobiographical memory (HSAM) raised the possibility that there may be individuals who are immune to memory distortions. We measured HSAM participants' and age- and sex-matched controls' susceptibility to false memories using several research paradigms. HSAM participants and controls were both susceptible to false recognition of nonpresented critical lure words in an associative word-list task. In a misinformation task, HSAM participants showed higher overall false memory compared with that of controls for details in a photographic slideshow...
December 24, 2013: Proceedings of the National Academy of Sciences of the United States of America
S L Hsam, F J Zeller
The present study describes the development of an alloplasmic haploid-inducer in durum wheat cv 'Cando'. This cultivar possesses the homozygous wheat-rye translocation 1BL/1RS from the 6x-wheat cv 'Veery'. The nucleus of 4x-'Cando-Veery 1BL/1RS' was introduced into Aegilops kotschyi cytoplasm by initially using (kotschyi)-Salmon as the maternal parent. In the cross of this alloplasmic durum line with 'Cando-Veery 1BL/1RS', which was used as the recurrent pollen parent, haploids (n=14) were produced. The frequency of haploids increased from 5...
September 1993: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
F J Zeller, S L Hsam
The chromosomal location of a suppressor for the powdery mildew resistance genes Pm8 and Pm17 was determined by a monosomic set of the wheat cultivar Caribo. This cultivar carries a suppressor gene inhibiting the expression of Pm8 in cv Disponent and of Pm17 in line Helami-105. In disease resistance assessments, monosomic F1 hybrids (2n=41) of Caribo x Disponent and Caribo x Helami-105 lacking chromosome 7D were resistant, whereas monosomic F1 hybrids involving the other 20 chromosomes, as well as disomic F1 hybrids (2n=42) of all cross combinations, were susceptible revealing that the suppressor gene for Pm8 and Pm17 is localized on chromosome 7D...
July 1996: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Haihe Wang, Chunyan Zhao, Fan Li
Rapid detection of Mycobacterium tuberculosis complex (MTBC) is a critical step in controlling tuberculosis (TB). In this study, we used IS6110 as the specific identification target to develop a novel hybridization signal amplification method (HSAM) for the rapid and direct detection of MTBC from clinical sputum specimens. This system consists of magnetic bead-linked capture probes for target isolation, dextran-based nanoparticles for amplifying the reporter molecule (biotinylated-FITC), and detection probes (2B-DNA) for binding the nanoparticles...
July 2011: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
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