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https://www.readbyqxmd.com/read/28940934/the-patterns-of-birthmarks-suggest-a-novel-population-of-melanocyte-precursors-arising-around-the-time-of-gastrulation
#1
REVIEW
Veronica A Kinsler, Lionel Larue
Systematic work in the mouse and chicken has mapped out two neural crest-derived pathways of melanocyte precursor migration. With these in mind, this study reappraises the patterns of congenital pigmentary disorders in humans, and identifies three recurrent patterns consistent across genetically-different diseases. Only two of these are seen in diseases known to be melanocyte cell-autonomous. The segmental pattern correlates well with the classical dorsolateral population from animal studies, demonstrating respect of the midline, craniocaudal axial mixing, unilateral migration and involvement of key epidermally-derived structures...
September 23, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28922416/multi-level-computational-methods-for-interdisciplinary-research-in-the-hathitrust-digital-library
#2
Jaimie Murdock, Colin Allen, Katy Börner, Robert Light, Simon McAlister, Andrew Ravenscroft, Robert Rose, Doori Rose, Jun Otsuka, David Bourget, John Lawrence, Chris Reed
We show how faceted search using a combination of traditional classification systems and mixed-membership topic models can go beyond keyword search to inform resource discovery, hypothesis formulation, and argument extraction for interdisciplinary research. Our test domain is the history and philosophy of scientific work on animal mind and cognition. The methods can be generalized to other research areas and ultimately support a system for semi-automatic identification of argument structures. We provide a case study for the application of the methods to the problem of identifying and extracting arguments about anthropomorphism during a critical period in the development of comparative psychology...
2017: PloS One
https://www.readbyqxmd.com/read/28821520/preclinical-medical-students-understandings-of-academic-and-medical-professionalism-visual-analysis-of-mind-maps
#3
Janusz Janczukowicz, Charlotte E Rees
INTRODUCTION: Several studies have begun to explore medical students' understandings of professionalism generally and medical professionalism specifically. Despite espoused relationships between academic (AP) and medical professionalism (MP), previous research has not yet investigated students' conceptualisations of AP and MP and the relationships between the two. OBJECTIVES: The current study, based on innovative visual analysis of mind maps, therefore aims to contribute to the developing literature on how professionalism is understood...
August 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28821381/evidence-from-blindness-for-a-cognitively-pluripotent-cortex
#4
REVIEW
Marina Bedny
Cognitive neuroscience seeks to discover how cognitive functions are implemented in neural circuits. Studies of plasticity in blindness suggest that this mind-brain mapping is highly flexible during development. In blindness, 'visual' cortices take on higher-cognitive functions, including language and mathematics, becoming sensitive to the grammatical structure of spoken sentences and the difficulty of math equations. Visual cortex activity at rest becomes synchronized with higher-cognitive networks. Such repurposing is striking in light of the cognitive and evolutionary differences between vision, language, and mathematics...
July 8, 2017: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/28821345/evidence-from-blindness-for-a-cognitively-pluripotent-cortex
#5
REVIEW
Marina Bedny
Cognitive neuroscience seeks to discover how cognitive functions are implemented in neural circuits. Studies of plasticity in blindness suggest that this mind-brain mapping is highly flexible during development. In blindness, 'visual' cortices take on higher-cognitive functions, including language and mathematics, becoming sensitive to the grammatical structure of spoken sentences and the difficulty of math equations. Visual cortex activity at rest becomes synchronized with higher-cognitive networks. Such repurposing is striking in light of the cognitive and evolutionary differences between vision, language, and mathematics...
September 2017: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/28818161/using-mind-maps-to-improve-medical-student-performance-in-a-pharmacology-course-at-kunming-medical-university
#6
Guo Ying, Xie Jianping, Luo Haiyun, Li Xia, Yang Jianyu, Xuan Qun, Yu Jianyun
OBJECTIVE: To determine whether students using mind maps would improve their performance in a final examination at the end of lecture-based pharmacology course. STUDY DESIGN: Aquasi-experimental study. PLACE AND DURATION OF STUDY: Kunming Medical University, from September 2014 to January 2015. METHODOLOGY: One hundred and twenty-two (122) third year undergraduate medical students, starting a 48-hour lecturebased pharmacology course, volunteered to use mind maps as one of their study strategies (intervention group), while the remaining 100 students in the class continued to use their usual study strategies (control group) over the duration of the course...
July 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28815771/molstack-interactive-visualization-tool-for-presentation-interpretation-and-validation-of-macromolecules-and-electron-density-maps
#7
Przemyslaw J Porebski, Piotr Sroka, Heping Zheng, David R Cooper, Wladek Minor
Our understanding of the world of biomolecular structures is based upon the interpretation of macromolecular models, of which ∼ 90% are themselves the interpretation of electron density maps. This structural information guides scientific progress and exploration in many biomedical disciplines. The Protein Data Bank's web portals have made these structures available for mass scientific consumption and greatly broaden the scope of information presented in scientific publications. The portals provide numerous quality metrics; however, the portion of the structure that is most vital for interpretation of the function may have the most difficult to interpret electron density and this ambiguity is not reflected by any single metric...
August 17, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28805399/mind-matters-a-meta-analysis-on-parental-mentalization-and-sensitivity-as-predictors-of-infant-parent-attachment
#8
Moniek A J Zeegers, Cristina Colonnesi, Geert-Jan J M Stams, Elizabeth Meins
Major developments in attachment research over the past 2 decades have introduced parental mentalization as a predictor of infant-parent attachment security. Parental mentalization is the degree to which parents show frequent, coherent, or appropriate appreciation of their infants' internal states. The present study examined the triangular relations between parental mentalization, parental sensitivity, and attachment security. A total of 20 effect sizes (N = 974) on the relation between parental mentalization and attachment, 82 effect sizes (N = 6,664) on the relation between sensitivity and attachment, and 24 effect sizes (N = 2,029) on the relation between mentalization and sensitivity were subjected to multilevel meta-analyses...
August 14, 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/28790343/strategic-tradeoffs-in-competitor-dynamics-on-adaptive-networks
#9
Laurent Hébert-Dufresne, Antoine Allard, Pierre-André Noël, Jean-Gabriel Young, Eric Libby
Recent empirical work highlights the heterogeneity of social competitions such as political campaigns: proponents of some ideologies seek debate and conversation, others create echo chambers. While symmetric and static network structure is typically used as a substrate to study such competitor dynamics, network structure can instead be interpreted as a signature of the competitor strategies, yielding competition dynamics on adaptive networks. Here we demonstrate that tradeoffs between aggressiveness and defensiveness (i...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28771180/investigation-of-exhaled-breath-samples-from-patients-with-alzheimer-s-disease-using-gas-chromatography-mass-spectrometry-and-an-exhaled-breath-sensor-system
#10
Hui-Chong Lau, Joon-Boo Yu, Ho-Won Lee, Jeung-Soo Huh, Jeong-Ok Lim
Exhaled breath is a body secretion, and the sampling process of this is simple and cost effective. It can be non-invasively collected for diagnostic procedures. Variations in the chemical composition of exhaled breath resulting from gaseous exchange in the extensive capillary network of the body are proposed to be associated with pathophysiological changes. In light of the foreseeable potential of exhaled breath as a diagnostic specimen, we used gas chromatography and mass spectrometry (GC-MS) to study the chemical compounds present in exhaled breath samples from patients with Alzheimer's disease (AD), Parkinson's disease (PD), and from healthy individuals as a control group...
August 3, 2017: Sensors
https://www.readbyqxmd.com/read/28768447/neural-oscillation-correlates-chemistry-decision-making
#11
Li-Yu Huang, Hsiao-Ching She, Tzyy-Ping Jung
This study explored the electroencephalography (EEG) dynamics during a chemistry-related decision-making task and further examined whether the correctness of the decision-making performance could be reflected by EEG activity. A total of 66 undergraduate students' EEG were collected while they participated in a chemistry-related decision-making task in which they had to retrieve the relevant chemistry concepts in order to make correct decisions for each task item. The results showed that it was only in the anterior cingulate cortex (ACC) cluster that distinct patterns in EEG dynamics were displayed for the correct and incorrect responses...
May 7, 2017: International Journal of Neural Systems
https://www.readbyqxmd.com/read/28753658/neuroanatomy-of-the-spleen-mapping-the-relationship-between-sympathetic-neurons-and-lymphocytes
#12
Kaitlin Murray, Dayn Romero Godinez, Ingrid Brust-Mascher, Elaine Nicole Miller, Melanie G Gareau, Colin Reardon
The nervous system plays a profound regulatory role in maintaining appropriate immune responses by signaling to immune cells. These immune cells, including B- and T-cells, can further act as intermediary messengers, with subsets of B- and T-cells expressing choline acetyltransferase (ChAT), the enzyme required for acetylcholine (ACh) synthesis. Neural control of ACh release from ChAT+ T-cells can have powerful immune implications, regulating lymphocyte trafficking, inflammation, and prevent death due to experimental septic shock...
2017: PloS One
https://www.readbyqxmd.com/read/28753372/towards-holography-via-quantum-source-channel-codes
#13
Fernando Pastawski, Jens Eisert, Henrik Wilming
While originally motivated by quantum computation, quantum error correction (QEC) is currently providing valuable insights into many-body quantum physics, such as topological phases of matter. Furthermore, mounting evidence originating from holography research (AdS/CFT) indicates that QEC should also be pertinent for conformal field theories. With this motivation in mind, we introduce quantum source-channel codes, which combine features of lossy compression and approximate quantum error correction, both of which are predicted in holography...
July 14, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28721738/counting-bodies-on-future-engagements-with-science-studies-in-medical-anthropology
#14
Emily Yates-Doerr
Thirty years ago, Nancy Scheper-Hughes and Margaret Lock outlined a strategy for 'future work in medical anthropology' that focused on three bodies. Their article - a zeitgeist for the field - sought to intervene into the Cartesian dualisms characterizing ethnomedical anthropology at the time. Taking a descriptive and diagnostic approach, they defined 'the mindful body' as a domain of future anthropological inquiry and mapped three analytic concepts that could be used to study it: the individual/phenomenological body, the social body, and the body politic...
August 2017: Anthropology & Medicine
https://www.readbyqxmd.com/read/28715777/regular-cannabis-and-alcohol-use-is-associated-with-resting-state-time-course-power-spectra-in-incarcerated-adolescents
#15
Sandra Thijssen, Barnaly Rashid, Shruti Gopal, Prashanth Nyalakanti, Vince D Calhoun, Kent A Kiehl
Cannabis and alcohol are believed to have widespread effects on the brain. Although adolescents are at increased risk for substance use, the adolescent brain may also be particularly vulnerable to the effects of drug exposure due to its rapid maturation. Here, we examined the association between cannabis and alcohol use duration and resting-state functional connectivity in a large sample of male juvenile delinquents. The present sample was drawn from the Southwest Advanced Neuroimaging Cohort, Youth sample, and from a youth detention facility in Wisconsin...
September 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28682255/visual-attention-saccadic-models-learn-to-emulate-gaze-patterns-from-childhood-to-adulthood
#16
Olivier Le Meur, Antoine Coutrot, Zhi Liu, Pia Rama, Adrien Le Roch, Andrea Helo
How people look at visual information reveals fundamental information about themselves, their interests and their state of mind. While previous visual attention models output static 2D saliency maps, saccadic models aim to predict not only where observers look at but also how they move their eyes to explore the scene. In this paper, we demonstrate that saccadic models are a flexible framework that can be tailored to emulate observer's viewing tendencies. More specifically, we use fixation data from 101 observers split into five age groups (adults, 8-10 y...
October 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28661193/-you-want-to-show-you-re-a-valuable-employee-a-critical-discourse-analysis-of-multi-perspective-portrayals-of-employed-women-with-fibromyalgia
#17
Margaret Oldfield, Ellen MacEachen, Margaret MacNeill, Bonnie Kirsh
Background Advice on fibromyalgia, a chronic illness primarily affecting women, often presents it as incompatible with work and rarely covers how to remain employed. Yet many women do. Objectives We aimed to understand how these women, their family members, and workmates portrayed employees with fibromyalgia, and how these portrayals helped women retain employment. Methods We interviewed 22 participants, comprising five triads and three dyads of people who knew each other. Using the methodology of critical discourse analysis, we analysed the interview data within and across the triads/dyads through coding, narrative summaries, and relational mapping...
January 1, 2017: Chronic Illness
https://www.readbyqxmd.com/read/28660744/reconceptualizing-mental-disorders-from-symptoms-to-organs
#18
Mario Bunge
Most mental pathologies are diagnosed on the sole basis of the symptoms reported by patients, such as "I'm feeling low." The thrust of this paper is the proposal to reconceptualize mental disorders as dysfunctions of brain subsystems. This shift from symptom to organ would bring psychiatry in line with the rest of medicine, and is analogous to the change in status of venereal infections from skin pathologies, such as chancres, to bacterial infections. The proposal in question is part of the reconceptualization of mental processes as brain processes, in line with the materialist conception of the mind as neural...
June 2017: PsyCh Journal
https://www.readbyqxmd.com/read/28641210/comparative-analysis-of-polyspecificity-of-the-endogenous-trna-synthetase-of-different-expression-host-towards-photocrosslinking-amino-acids-using-an-in-silico-approach
#19
Nadarajan Saravanan Prabhu, Hyungdon Yun
Photo-induced covalent crosslinking has emerged as the powerful strategy for analyzing and characterizing the protein-protein interaction and mapping protein 3D conformations. In the last decades, a number of photocrosslinking amino acids have been reported but only a few have been efficiently utilized for photocrosslinking purposes. Recently, incorporation of diazirine containing photoactivatable analogs such as photo-methionine, photo-leucine, photo-isoleucine and photo-lysine into target proteins were accomplished in live cells (Human A549cells, HEK 293) by depleting corresponding natural amino acid and supplementing these analogs in the medium...
June 8, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28640821/noise-reduction-in-single-time-frame-optical-dna-maps
#20
Paola C Torche, Vilhelm Müller, Fredrik Westerlund, Tobias Ambjörnsson
In optical DNA mapping technologies sequence-specific intensity variations (DNA barcodes) along stretched and stained DNA molecules are produced. These "fingerprints" of the underlying DNA sequence have a resolution of the order one kilobasepairs and the stretching of the DNA molecules are performed by surface adsorption or nano-channel setups. A post-processing challenge for nano-channel based methods, due to local and global random movement of the DNA molecule during imaging, is how to align different time frames in order to produce reproducible time-averaged DNA barcodes...
2017: PloS One
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