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barrie Robinson

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https://www.readbyqxmd.com/read/27780169/the-effects-of-carvedilol-on-cardiac-function-and-the-akt-xiap-signaling-pathway-in-diabetic-cardiomyopathy-rats
#1
Wencheng Zheng, Xiaoming Shang, Chunlai Zhang, Xiang Gao, Barry Robinson, Jing Liu
OBJECTIVES: Diabetic cardiomyopathy (DCM) is characterized by cardiac dysfunction, myocardial inflammation, interstitial fibrosis and cardiomyocytes apoptosis. The present study aimed to investigate the effects of carvedilol on cardiac function and the AKT/XIAP signaling pathway in DCM rats. METHODS: Male Wistar rats were randomly divided into 3 groups: the control group, diabetic mellitus (DM) group and DM with carvedilol treatment group. DM rats were induced by streptozotocin accompanied by high energy intake...
October 26, 2016: Cardiology
https://www.readbyqxmd.com/read/27598850/mechanical-player-load%C3%A2-using-trunk-mounted-accelerometry-in-football-is-it-a-reliable-task-and-player-specific-observation
#2
Paulo Barreira, Mark A Robinson, Barry Drust, Niels Nedergaard, Raja Mohammed Firhad Raja Azidin, Jos Vanrenterghem
The aim of the present study was to examine reliability and construct convergent validity of Player Load™ (PL) from trunk-mounted accelerometry, expressed as a cumulative measure and an intensity measure (PL · min(-)(1)). Fifteen male participants twice performed an overground football match simulation that included four different multidirectional football actions (jog, side cut, stride and sprint) whilst wearing a trunk-mounted accelerometer inbuilt in a global positioning system unit. Results showed a moderate-to-high reliability as indicated by the intra-class correlation coefficient (0...
September 6, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27449787/cost-effectiveness-analysis-of-offering-free-leisure-centre-memberships-to-physically-inactive-members-of-the-public-receiving-state-benefits-a-case-study
#3
Talitha I Verhoef, Verena Trend, Barry Kelly, Nigel Robinson, Paul Fox, Stephen Morris
BACKGROUND: We evaluated the cost-effectiveness of the Give-it-a-Go programme, which offers free leisure centre memberships to physically inactive members of the public in a single London Borough receiving state benefits. METHODS: A decision analytic Markov model was developed to analyse lifetime costs and quality-adjusted life-years (QALYs) of 1025 people recruited to the intervention versus no intervention. In the intervention group, people were offered 4 months of free membership at a leisure centre...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27284213/improvements-in-cd-stable-isotope-analysis-achieved-through-use-of-liquid-liquid-extraction-to-remove-organic-residues-from-cd-separates-obtained-by-extraction-chromatography
#4
Katy Murphy, Mark Rehkämper, Katharina Kreissig, Barry Coles, Tina van de Flierdt
Organic compounds released from resins that are commonly employed for trace element separations are known to have a detrimental impact on the quality of isotopic analyses by MC-ICP-MS. A recent study highlighted that such effects can be particularly problematic for Cd stable isotope measurements (M. Gault-Ringold and C. H. Stirling, J. Anal. At. Spectrom., 2012, 27, 449-459). In this case, the final stage of sample purification commonly applies extraction chromatography with Eichrom TRU resin, which employs particles coated with octylphenyl-N,N-di-isobutyl carbamoylphosphine oxide (CMPO) dissolved in tri-n-butyl phosphate (TBP)...
January 23, 2016: Journal of Analytical Atomic Spectrometry
https://www.readbyqxmd.com/read/27079714/potentially-inappropriate-prescribing-among-people-with-dementia-in-primary-care-a-retrospective-cross-sectional-study-using-the-enhanced-prescribing-database
#5
Heather E Barry, Janine A Cooper, Cristín Ryan, A Peter Passmore, A Louise Robinson, Gerard J Molloy, Carmel M Darcy, Hilary Buchanan, Carmel M Hughes
BACKGROUND: Little is known about prescribing appropriateness for community-dwelling people with dementia (PWD). OBJECTIVE: To estimate potentially inappropriate prescribing (PIP) prevalence among PWD in primary care in Northern Ireland, and to investigate associations between PIP, polypharmacy, age, and gender. METHODS: A retrospective cross-sectional study was conducted, using data from the Enhanced Prescribing Database. Patients were eligible if a medicine indicated for dementia management was dispensed to them during 1 January 2013-31 December 2013...
April 11, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27076664/do-staphylococcus-epidermidis-genetic-clusters-predict-isolation-sources
#6
Isaiah Tolo, Jonathan C Thomas, Rebecca S B Fischer, Eric L Brown, Barry M Gray, D Ashley Robinson
Staphylococcus epidermidis is a ubiquitous colonizer of human skin and a common cause of medical device-associated infections. The extent to which the population genetic structure of S. epidermidis distinguishes commensal from pathogenic isolates is unclear. Previously, Bayesian clustering of 437 multilocus sequence types (STs) in the international database revealed a population structure of six genetic clusters (GCs) that may reflect the species' ecology. Here, we first verified the presence of six GCs, including two (GC3 and GC5) with significant admixture, in an updated database of 578 STs...
July 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27057778/normative-values-for-electrochemical-skin-conductances-and-impact-of-ethnicity-on-quantitative-assessment-of-sudomotor-function
#7
Aaron I Vinik, A Gordon Smith, J Robinson Singleton, Brian Callaghan, Barry I Freedman, Jaakko Tuomilehto, Lyse Bordier, Bernard Bauduceau, Frederic Roche
BACKGROUND: Sudomotor dysfunction is one of the earliest pathophysiologic abnormalities in diabetes. Sudoscan™ (Impeto Medical, Paris, France) was developed as a noninvasive, rapid, and quantitative assessment of sudomotor function and has been shown to be sensitive in the detection of neuropathy. This global collaborative analysis aimed to establish reference values in healthy subjects of different ethnic groups, age, and gender, to define factors potentially affecting results, and to provide standardization of the methodology...
June 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27040285/risk-stratification-of-childhood-medulloblastoma-in-the-molecular-era-the-current-consensus
#8
Vijay Ramaswamy, Marc Remke, Eric Bouffet, Simon Bailey, Steven C Clifford, Francois Doz, Marcel Kool, Christelle Dufour, Gilles Vassal, Till Milde, Olaf Witt, Katja von Hoff, Torsten Pietsch, Paul A Northcott, Amar Gajjar, Giles W Robinson, Laetitia Padovani, Nicolas André, Maura Massimino, Barry Pizer, Roger Packer, Stefan Rutkowski, Stefan M Pfister, Michael D Taylor, Scott L Pomeroy
Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological variables pertaining to age, presence of metastases, extent of resection, histological subtypes and in some instances individual genetic aberrations such as MYC and MYCN amplification. In 2010, an international panel of experts established consensus defining four main subgroups of medulloblastoma (WNT, SHH, Group 3 and Group 4) delineated by transcriptional profiling. This has led to the current generation of biomarker-driven clinical trials assigning WNT tumors to a favorable prognosis group in addition to clinicopathological criteria including MYC and MYCN gene amplifications...
June 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/27002795/the-relationship-between-whole-body-external-loading-and-body-worn-accelerometry-during-team-sports-movements
#9
Niels J Nedergaard, Mark A Robinson, Elena Eusterwiemann, Barry Drust, Paulo J Lisboa, Jos Vanrenterghem
PURPOSE: The aim of this study was to investigate the relationship between whole-body accelerations and body-worn accelerometry during team sports movements. METHODS: Twenty male team sport players performed forward running, and anticipated 45° and 90° side-cuts at approach speeds of 2, 3, 4 and 5 m·s-1. Whole-body Centre of Mass (CoM) accelerations were determined from ground reaction forces collected from one foot-ground-contact and segmental accelerations were measured from a commercial GPS/accelerometer unit on the upper trunk...
March 22, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/26912495/where-people-shop-is-not-associated-with-the-nutrient-quality-of-packaged-foods-for-any-racial-ethnic-group-in-the-united-states
#10
Dalia Stern, Jennifer M Poti, Shu Wen Ng, Whitney R Robinson, Penny Gordon-Larsen, Barry M Popkin
BACKGROUND: In the literature, it has been suggested that there are race-ethnic disparities in what Americans eat. In addition, some studies have shown that residents of African American and low-income neighborhoods have less access to grocery stores and supermarkets, which tend to stock healthier foods. However, it is unclear whether differences in food shopping patterns contribute to the poorer nutrient profile of food purchases made by racial-ethnic minorities. OBJECTIVES: We examined whether the mix of food stores where people shop (i...
April 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/26792595/genetic-susceptibility-loci-of-idiopathic-interstitial-pneumonia-do-not-represent-risk-for-systemic-sclerosis-a-case-control-study-in-caucasian-patients
#11
Minghua Wu, Shervin Assassi, Gloria A Salazar, Claudia Pedroza, Olga Y Gorlova, Wei V Chen, Julio Charles, Miranda L Taing, Kelley Liao, Fredrick M Wigley, Laura K Hummers, Ami A Shah, Monique Hinchcliff, Dinesh Khanna, Elena Schiopu, Kristine Phillips, Daniel E Furst, Virginia Steen, Murray Baron, Marie Hudson, Xiaodong Zhou, Janet Pope, Niall Jones, Peter Docherty, Nader A Khalidi, David Robinson, Robert W Simms, Richard M Silver, Tracy M Frech, Barri J Fessler, Marvin J Fritzler, Jerry A Molitor, Barbara M Segal, Malahat Movahedian, Javier Martín, John Varga, Maureen D Mayes
BACKGROUND: Systemic sclerosis (SSc)-related interstitial lung disease (ILD) has phenotypic similarities to lung involvement in idiopathic interstitial pneumonia (IIP). We aimed to assess whether genetic susceptibility loci recently identified in the large IIP genome-wide association studies (GWASs) were also risk loci for SSc overall or severity of ILD in SSc. METHODS: A total of 2571 SSc patients and 4500 healthy controls were investigated from the US discovery GWAS and additional US replication cohorts...
January 20, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/26780094/integrative-genomic-analysis-by-interoperation-of-bioinformatics-tools-in-genomespace
#12
Kun Qu, Sara Garamszegi, Felix Wu, Helga Thorvaldsdottir, Ted Liefeld, Marco Ocana, Diego Borges-Rivera, Nathalie Pochet, James T Robinson, Barry Demchak, Tim Hull, Gil Ben-Artzi, Daniel Blankenberg, Galt P Barber, Brian T Lee, Robert M Kuhn, Anton Nekrutenko, Eran Segal, Trey Ideker, Michael Reich, Aviv Regev, Howard Y Chang, Jill P Mesirov
Complex biomedical analyses require the use of multiple software tools in concert and remain challenging for much of the biomedical research community. We introduce GenomeSpace (http://www.genomespace.org), a cloud-based, cooperative community resource that currently supports the streamlined interaction of 20 bioinformatics tools and data resources. To facilitate integrative analysis by non-programmers, it offers a growing set of 'recipes', short workflows to guide investigators through high-utility analysis tasks...
March 2016: Nature Methods
https://www.readbyqxmd.com/read/26623967/hepatitis-e-virus-infection-and-acute-on-chronic-liver-failure-in-west-africa-a-case-control-study-from-the-gambia
#13
Y Shimakawa, H F Njai, K Takahashi, L Berg, G Ndow, A Jeng-Barry, A Ceesay, S Tamba, E Opoku, M Taal, S M F Akbar, M Arai, U D'Alessandro, S D Taylor-Robinson, R Njie, S Mishiro, M R Thursz, M Lemoine
BACKGROUND: In sub-Saharan Africa, it is unknown whether hepatitis E virus (HEV) infection is a common precipitating event of acute-on-chronic liver failure (ACLF). AIMS: To estimate the prevalence of HEV infection in general population and assess whether HEV is a common trigger of ACLF in cirrhotic patients in The Gambia, West Africa. METHODS: We first conducted an HEV sero-survey in healthy volunteers. We then tested cirrhotic patients with ACLF (cases) and compensated cirrhosis (controls) for anti-HEV IgG as a marker of exposure to HEV, and anti-HEV IgA and HEV RNA as a marker of recent infection...
February 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/26526241/us-household-food-shopping-patterns-dynamic-shifts-since-2000-and-socioeconomic-predictors
#14
Dalia Stern, Whitney R Robinson, Shu Wen Ng, Penny Gordon-Larsen, Barry M Popkin
Under the assumption that differential food access might underlie nutritional disparities, programs and policies have focused on the need to build supermarkets in underserved areas, in an effort to improve dietary quality. However, there is limited evidence about which types of stores are used by households of different income levels and differing races/ethnicities. We used cross-sectional cluster analysis to derive shopping patterns from US households' volume food purchases by store from 2000 to 2012. Multinomial logistic regression identified household socioeconomic characteristics that were associated with shopping patterns in 2012...
November 2015: Health Affairs
https://www.readbyqxmd.com/read/26487157/association-between-young-australian-s-drinking-behaviours-and-their-interactions-with-alcohol-brands-on-facebook-results-of-an-online-survey
#15
Sandra C Jones, Laura Robinson, Lance Barrie, Kate Francis, Jeong Kyu Lee
AIMS: To examine the association of alcohol-brand social networking pages and Facebook users' drinking attitudes and behaviours. METHODS: Cross-sectional, self-report data were obtained from a convenience sample of 283 Australian Facebook users aged 16-24 years via an online survey. RESULTS: More than half of the respondents reported using Facebook for more than an hour daily. While only 20% had actively interacted with an alcohol brand on Facebook, we found a significant association between this active interaction and alcohol consumption, and a strong association between engagement with alcohol brands on Facebook and problematic drinking...
July 2016: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/26061706/seen-and-heard-towards-child-participation-in-dental-research
#16
Zoe Marshman, Ekta Gupta, Sarah R Baker, Peter G Robinson, Janine Owens, Helen D Rodd, Philip E Benson, Barry Gibson
BACKGROUND: There has been an increasing emphasis in many countries worldwide to capture the views of children on health services and research. A previous systematic review found that most oral health research from 2000 to 2005 was conducted on children and highlighted the need for greater research with children. AIM: To describe the extent to which oral health research between 2006 and 2014 has been conducted with or on children. DESIGN: Systematic review...
September 2015: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/25996916/blood-stage-parasitaemia-and-age-determine-plasmodium-falciparum-and-p-vivax-gametocytaemia-in-papua-new-guinea
#17
Cristian Koepfli, Leanne J Robinson, Patricia Rarau, Mary Salib, Naomi Sambale, Rahel Wampfler, Inoni Betuela, Wang Nuitragool, Alyssa E Barry, Peter Siba, Ingrid Felger, Ivo Mueller
A better understanding of human-to-mosquito transmission is crucial to control malaria. In order to assess factors associated with gametocyte carriage, 2083 samples were collected in a cross-sectional survey in Papua New Guinea. Plasmodium species were detected by light microscopy and qPCR and gametocytes by detection of pfs25 and pvs25 mRNA transcripts by reverse-transcriptase PCR (qRT-PCR). The parasite prevalence by PCR was 18.5% for Plasmodium falciparum and 13.0% for P. vivax. 52.5% of all infections were submicroscopic...
2015: PloS One
https://www.readbyqxmd.com/read/25788095/the-fine-scale-genetic-structure-of-the-british-population
#18
Stephen Leslie, Bruce Winney, Garrett Hellenthal, Dan Davison, Abdelhamid Boumertit, Tammy Day, Katarzyna Hutnik, Ellen C Royrvik, Barry Cunliffe, Daniel J Lawson, Daniel Falush, Colin Freeman, Matti Pirinen, Simon Myers, Mark Robinson, Peter Donnelly, Walter Bodmer
Fine-scale genetic variation between human populations is interesting as a signature of historical demographic events and because of its potential for confounding disease studies. We use haplotype-based statistical methods to analyse genome-wide single nucleotide polymorphism (SNP) data from a carefully chosen geographically diverse sample of 2,039 individuals from the United Kingdom. This reveals a rich and detailed pattern of genetic differentiation with remarkable concordance between genetic clusters and geography...
March 19, 2015: Nature
https://www.readbyqxmd.com/read/25583274/effects-of-treadmill-versus-overground-soccer-match-simulations-on-biomechanical-markers-of-anterior-cruciate-ligament-injury-risk-in-side-cutting
#19
RANDOMIZED CONTROLLED TRIAL
R M Firhad Raja Azidin, Sean Sankey, Barry Drust, Mark A Robinson, Jos Vanrenterghem
This study aimed to investigate whether treadmill versus overground soccer match simulations have similar effects on knee joint mechanics during side cutting. Nineteen male recreational soccer players completed a 45-min treadmill and overground match simulation. Heart rate (HR) and rating of perceived exertion (RPE) were recorded every 5 min. Prior to exercise (time 0 min), at "half-time" (time 45 min) and 15 min post-exercise (time 60 min), participants performed five trials of 45° side-cutting manoeuvres...
2015: Journal of Sports Sciences
https://www.readbyqxmd.com/read/25578738/antinuclear-antibody-negative-systemic-sclerosis
#20
Gloria A Salazar, Shervin Assassi, Fredrick Wigley, Laura Hummers, John Varga, Monique Hinchcliff, Dinesh Khanna, Elena Schiopu, Kristine Phillips, Daniel E Furst, Virginia Steen, Murray Baron, Marie Hudson, Suzanne S Taillefer, Janet Pope, Niall Jones, Peter Docherty, Nader A Khalidi, David Robinson, Robert W Simms, Richard M Silver, Tracy M Frech, Barri J Fessler, Jerry A Molitor, Marvin J Fritzler, Barbara M Segal, Firas Al-Kassab, Marilyn Perry, Jeremy Yang, Sara Zamanian, John D Reveille, Frank C Arnett, Claudia Pedroza, Maureen D Mayes
OBJECTIVE: To examine the demographic and clinical characteristics of systemic sclerosis (SSc) patients without antinuclear antibodies (ANA) compared to ANA-positive patients. METHODS: SSc patients enrolled in the Scleroderma Family Registry and DNA Repository were included. Relevant demographic and clinical data were entered by participating sites or obtained by chart review. ANA and SSc-related antibodies were determined in all investigated patients using commercially available kits at our laboratories...
June 2015: Seminars in Arthritis and Rheumatism
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