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https://www.readbyqxmd.com/read/28298955/the-apolipoprotein-l1-gene-and-cardiovascular-disease
#1
Todd W Robinson, Barry I Freedman
Relative to those with European ancestry, African Americans have an excess incidence of nondiabetic chronic kidney disease predominantly due to two coding renal-risk variants in the apolipoprotein L1 gene (APOL1). This APOL1-kidney disease association is independent of systemic hypertension or blood pressure. Recent reports describe extra-renal effects of the APOL1 G1 and G2 renal-risk variants on cardiovascular disease (CVD), subclinical atherosclerosis, lipoprotein particle concentrations, and survival. However, results have been less consistent than those seen in kidney disease, and the observed APOL1 associations with CVD vary from risk to protective...
October 2016: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/28283992/training-load-monitoring-in-team-sports-a-novel-framework-separating-physiological-and-biomechanical-load-adaptation-pathways
#2
Jos Vanrenterghem, Niels Jensby Nedergaard, Mark A Robinson, Barry Drust
There have been considerable advances in monitoring training load in running-based team sports in recent years. Novel technologies nowadays offer ample opportunities to continuously monitor the activities of a player. These activities lead to internal biochemical stresses on the various physiological subsystems; however, they also cause internal mechanical stresses on the various musculoskeletal tissues. Based on the amount and periodization of these stresses, the subsystems and tissues adapt. Therefore, by monitoring external loads, one hopes to estimate internal loads to predict adaptation, through understanding the load-adaptation pathways...
March 10, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28143671/apol1-gene-kidney-risk-variants-and-cardiovascular-disease-getting-to-the-heart-of-the-matter
#3
REVIEW
Nicholas O McLean, Todd W Robinson, Barry I Freedman
Apolipoprotein L1 gene (APOL1) renal risk variants exhibit strong genetic associations with a spectrum of nondiabetic kidney diseases in individuals with recent African ancestry. Relationships between APOL1 kidney risk variants and cardiovascular disease (CVD) susceptibility and CVD-related death remain controversial. Some studies detected an increased risk for CVD, whereas others support protection from death and subclinical CVD and cerebrovascular disease. Because treatments for nondiabetic kidney disease may target this gene and its protein products, it remains critical to clarify the potential extrarenal effects of APOL1 kidney risk variants...
January 28, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28087008/apol1-genotype-blood-pressure-and-survival-in-african-americans-with-nondiabetic-nephropathy
#4
Todd W Robinson, Barry I Freedman
Several landmark trials have assessed the effects of aggressive hypertension control on the progression of nondiabetic chronic kidney disease. Results generally have been disappointing. With the realization that lowering blood pressure, including with renin-angiotensin system blockade, failed to reliably prevent end-stage kidney disease, studies now are analyzing longer-term effects of hypertension control on survival in chronic kidney disease. This commentary reviews the current findings and extends the discussion to apolipoprotein L1 gene by blood pressure (or gene by environment) interactions...
February 2017: Kidney International
https://www.readbyqxmd.com/read/28064386/brief-supportive-expressive-group-therapy-for-partners-of-men-with-early-stage-prostate-cancer-lessons-learned-from-a-negative-randomized-controlled-trial
#5
Linda E Carlson, Codie R Rouleau, Michael Speca, John Robinson, Barry D Bultz
PURPOSE: The purpose of this paper is to report the results of a negative randomized controlled trial, which piloted brief supportive-expressive therapy (SET) for partners of men with prostate cancer, and to discuss lessons learned for future clinical trials. METHODS: Partners of men with newly diagnosed, non-metastatic prostate cancer were randomized to SET (n = 45) or usual care (n = 32). SET involved six weekly group sessions emphasizing emotional expression, social support, and finding meaning in the cancer experience...
January 7, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27780169/the-effects-of-carvedilol-on-cardiac-function-and-the-akt-xiap-signaling-pathway-in-diabetic-cardiomyopathy-rats
#6
Wencheng Zheng, Xiaoming Shang, Chunlai Zhang, Xiang Gao, Barry Robinson, Jing Liu
OBJECTIVES: Diabetic cardiomyopathy (DCM) is characterized by cardiac dysfunction, myocardial inflammation, interstitial fibrosis and cardiomyocytes apoptosis. The present study aimed to investigate the effects of carvedilol on cardiac function and the AKT/XIAP signaling pathway in DCM rats. METHODS: Male Wistar rats were randomly divided into 3 groups: the control group, diabetic mellitus (DM) group and DM with carvedilol treatment group. DM rats were induced by streptozotocin accompanied by high energy intake...
2017: Cardiology
https://www.readbyqxmd.com/read/27598850/mechanical-player-load%C3%A2-using-trunk-mounted-accelerometry-in-football-is-it-a-reliable-task-and-player-specific-observation
#7
Paulo Barreira, Mark A Robinson, Barry Drust, Niels Nedergaard, Raja Mohammed Firhad Raja Azidin, Jos Vanrenterghem
The aim of the present study was to examine reliability and construct convergent validity of Player Load™ (PL) from trunk-mounted accelerometry, expressed as a cumulative measure and an intensity measure (PL · min(-)(1)). Fifteen male participants twice performed an overground football match simulation that included four different multidirectional football actions (jog, side cut, stride and sprint) whilst wearing a trunk-mounted accelerometer inbuilt in a global positioning system unit. Results showed a moderate-to-high reliability as indicated by the intra-class correlation coefficient (0...
September 6, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27449787/cost-effectiveness-analysis-of-offering-free-leisure-centre-memberships-to-physically-inactive-members-of-the-public-receiving-state-benefits-a-case-study
#8
Talitha I Verhoef, Verena Trend, Barry Kelly, Nigel Robinson, Paul Fox, Stephen Morris
BACKGROUND: We evaluated the cost-effectiveness of the Give-it-a-Go programme, which offers free leisure centre memberships to physically inactive members of the public in a single London Borough receiving state benefits. METHODS: A decision analytic Markov model was developed to analyse lifetime costs and quality-adjusted life-years (QALYs) of 1025 people recruited to the intervention versus no intervention. In the intervention group, people were offered 4 months of free membership at a leisure centre...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27284213/improvements-in-cd-stable-isotope-analysis-achieved-through-use-of-liquid-liquid-extraction-to-remove-organic-residues-from-cd-separates-obtained-by-extraction-chromatography
#9
Katy Murphy, Mark Rehkämper, Katharina Kreissig, Barry Coles, Tina van de Flierdt
Organic compounds released from resins that are commonly employed for trace element separations are known to have a detrimental impact on the quality of isotopic analyses by MC-ICP-MS. A recent study highlighted that such effects can be particularly problematic for Cd stable isotope measurements (M. Gault-Ringold and C. H. Stirling, J. Anal. At. Spectrom., 2012, 27, 449-459). In this case, the final stage of sample purification commonly applies extraction chromatography with Eichrom TRU resin, which employs particles coated with octylphenyl-N,N-di-isobutyl carbamoylphosphine oxide (CMPO) dissolved in tri-n-butyl phosphate (TBP)...
January 23, 2016: Journal of Analytical Atomic Spectrometry
https://www.readbyqxmd.com/read/27079714/potentially-inappropriate-prescribing-among-people-with-dementia-in-primary-care-a-retrospective-cross-sectional-study-using-the-enhanced-prescribing-database
#10
Heather E Barry, Janine A Cooper, Cristín Ryan, A Peter Passmore, A Louise Robinson, Gerard J Molloy, Carmel M Darcy, Hilary Buchanan, Carmel M Hughes
BACKGROUND: Little is known about prescribing appropriateness for community-dwelling people with dementia (PWD). OBJECTIVE: To estimate potentially inappropriate prescribing (PIP) prevalence among PWD in primary care in Northern Ireland, and to investigate associations between PIP, polypharmacy, age, and gender. METHODS: A retrospective cross-sectional study was conducted, using data from the Enhanced Prescribing Database. Patients were eligible if a medicine indicated for dementia management was dispensed to them during 1 January 2013-31 December 2013...
April 11, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27076664/do-staphylococcus-epidermidis-genetic-clusters-predict-isolation-sources
#11
Isaiah Tolo, Jonathan C Thomas, Rebecca S B Fischer, Eric L Brown, Barry M Gray, D Ashley Robinson
Staphylococcus epidermidis is a ubiquitous colonizer of human skin and a common cause of medical device-associated infections. The extent to which the population genetic structure of S. epidermidis distinguishes commensal from pathogenic isolates is unclear. Previously, Bayesian clustering of 437 multilocus sequence types (STs) in the international database revealed a population structure of six genetic clusters (GCs) that may reflect the species' ecology. Here, we first verified the presence of six GCs, including two (GC3 and GC5) with significant admixture, in an updated database of 578 STs...
July 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27057778/normative-values-for-electrochemical-skin-conductances-and-impact-of-ethnicity-on-quantitative-assessment-of-sudomotor-function
#12
Aaron I Vinik, A Gordon Smith, J Robinson Singleton, Brian Callaghan, Barry I Freedman, Jaakko Tuomilehto, Lyse Bordier, Bernard Bauduceau, Frederic Roche
BACKGROUND: Sudomotor dysfunction is one of the earliest pathophysiologic abnormalities in diabetes. Sudoscan™ (Impeto Medical, Paris, France) was developed as a noninvasive, rapid, and quantitative assessment of sudomotor function and has been shown to be sensitive in the detection of neuropathy. This global collaborative analysis aimed to establish reference values in healthy subjects of different ethnic groups, age, and gender, to define factors potentially affecting results, and to provide standardization of the methodology...
June 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27040285/risk-stratification-of-childhood-medulloblastoma-in-the-molecular-era-the-current-consensus
#13
Vijay Ramaswamy, Marc Remke, Eric Bouffet, Simon Bailey, Steven C Clifford, Francois Doz, Marcel Kool, Christelle Dufour, Gilles Vassal, Till Milde, Olaf Witt, Katja von Hoff, Torsten Pietsch, Paul A Northcott, Amar Gajjar, Giles W Robinson, Laetitia Padovani, Nicolas André, Maura Massimino, Barry Pizer, Roger Packer, Stefan Rutkowski, Stefan M Pfister, Michael D Taylor, Scott L Pomeroy
Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological variables pertaining to age, presence of metastases, extent of resection, histological subtypes and in some instances individual genetic aberrations such as MYC and MYCN amplification. In 2010, an international panel of experts established consensus defining four main subgroups of medulloblastoma (WNT, SHH, Group 3 and Group 4) delineated by transcriptional profiling. This has led to the current generation of biomarker-driven clinical trials assigning WNT tumors to a favorable prognosis group in addition to clinicopathological criteria including MYC and MYCN gene amplifications...
June 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/27002795/the-relationship-between-whole-body-external-loading-and-body-worn-accelerometry-during-team-sport-movements
#14
Niels J Nedergaard, Mark A Robinson, Elena Eusterwiemann, Barry Drust, Paulo J Lisboa, Jos Vanrenterghem
PURPOSE: To investigate the relationship between whole-body accelerations and body-worn accelerometry during team-sport movements. METHODS: Twenty male team-sport players performed forward running and anticipated 45° and 90° side-cuts at approach speeds of 2, 3, 4, and 5 m/s. Whole-body center-of-mass (CoM) accelerations were determined from ground-reaction forces collected from 1 foot-ground contact, and segmental accelerations were measured from a commercial GPS accelerometer unit on the upper trunk...
January 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/26912495/where-people-shop-is-not-associated-with-the-nutrient-quality-of-packaged-foods-for-any-racial-ethnic-group-in-the-united-states
#15
Dalia Stern, Jennifer M Poti, Shu Wen Ng, Whitney R Robinson, Penny Gordon-Larsen, Barry M Popkin
BACKGROUND: In the literature, it has been suggested that there are race-ethnic disparities in what Americans eat. In addition, some studies have shown that residents of African American and low-income neighborhoods have less access to grocery stores and supermarkets, which tend to stock healthier foods. However, it is unclear whether differences in food shopping patterns contribute to the poorer nutrient profile of food purchases made by racial-ethnic minorities. OBJECTIVES: We examined whether the mix of food stores where people shop (i...
April 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/26792595/genetic-susceptibility-loci-of-idiopathic-interstitial-pneumonia-do-not-represent-risk-for-systemic-sclerosis-a-case-control-study-in-caucasian-patients
#16
Minghua Wu, Shervin Assassi, Gloria A Salazar, Claudia Pedroza, Olga Y Gorlova, Wei V Chen, Julio Charles, Miranda L Taing, Kelley Liao, Fredrick M Wigley, Laura K Hummers, Ami A Shah, Monique Hinchcliff, Dinesh Khanna, Elena Schiopu, Kristine Phillips, Daniel E Furst, Virginia Steen, Murray Baron, Marie Hudson, Xiaodong Zhou, Janet Pope, Niall Jones, Peter Docherty, Nader A Khalidi, David Robinson, Robert W Simms, Richard M Silver, Tracy M Frech, Barri J Fessler, Marvin J Fritzler, Jerry A Molitor, Barbara M Segal, Malahat Movahedian, Javier Martín, John Varga, Maureen D Mayes
BACKGROUND: Systemic sclerosis (SSc)-related interstitial lung disease (ILD) has phenotypic similarities to lung involvement in idiopathic interstitial pneumonia (IIP). We aimed to assess whether genetic susceptibility loci recently identified in the large IIP genome-wide association studies (GWASs) were also risk loci for SSc overall or severity of ILD in SSc. METHODS: A total of 2571 SSc patients and 4500 healthy controls were investigated from the US discovery GWAS and additional US replication cohorts...
January 20, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/26780094/integrative-genomic-analysis-by-interoperation-of-bioinformatics-tools-in-genomespace
#17
Kun Qu, Sara Garamszegi, Felix Wu, Helga Thorvaldsdottir, Ted Liefeld, Marco Ocana, Diego Borges-Rivera, Nathalie Pochet, James T Robinson, Barry Demchak, Tim Hull, Gil Ben-Artzi, Daniel Blankenberg, Galt P Barber, Brian T Lee, Robert M Kuhn, Anton Nekrutenko, Eran Segal, Trey Ideker, Michael Reich, Aviv Regev, Howard Y Chang, Jill P Mesirov
Complex biomedical analyses require the use of multiple software tools in concert and remain challenging for much of the biomedical research community. We introduce GenomeSpace (http://www.genomespace.org), a cloud-based, cooperative community resource that currently supports the streamlined interaction of 20 bioinformatics tools and data resources. To facilitate integrative analysis by non-programmers, it offers a growing set of 'recipes', short workflows to guide investigators through high-utility analysis tasks...
March 2016: Nature Methods
https://www.readbyqxmd.com/read/26623967/hepatitis-e-virus-infection-and-acute-on-chronic-liver-failure-in-west-africa-a-case-control-study-from-the-gambia
#18
Y Shimakawa, H F Njai, K Takahashi, L Berg, G Ndow, A Jeng-Barry, A Ceesay, S Tamba, E Opoku, M Taal, S M F Akbar, M Arai, U D'Alessandro, S D Taylor-Robinson, R Njie, S Mishiro, M R Thursz, M Lemoine
BACKGROUND: In sub-Saharan Africa, it is unknown whether hepatitis E virus (HEV) infection is a common precipitating event of acute-on-chronic liver failure (ACLF). AIMS: To estimate the prevalence of HEV infection in general population and assess whether HEV is a common trigger of ACLF in cirrhotic patients in The Gambia, West Africa. METHODS: We first conducted an HEV sero-survey in healthy volunteers. We then tested cirrhotic patients with ACLF (cases) and compensated cirrhosis (controls) for anti-HEV IgG as a marker of exposure to HEV, and anti-HEV IgA and HEV RNA as a marker of recent infection...
February 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/26526241/us-household-food-shopping-patterns-dynamic-shifts-since-2000-and-socioeconomic-predictors
#19
Dalia Stern, Whitney R Robinson, Shu Wen Ng, Penny Gordon-Larsen, Barry M Popkin
Under the assumption that differential food access might underlie nutritional disparities, programs and policies have focused on the need to build supermarkets in underserved areas, in an effort to improve dietary quality. However, there is limited evidence about which types of stores are used by households of different income levels and differing races/ethnicities. We used cross-sectional cluster analysis to derive shopping patterns from US households' volume food purchases by store from 2000 to 2012. Multinomial logistic regression identified household socioeconomic characteristics that were associated with shopping patterns in 2012...
November 2015: Health Affairs
https://www.readbyqxmd.com/read/26487157/association-between-young-australian-s-drinking-behaviours-and-their-interactions-with-alcohol-brands-on-facebook-results-of-an-online-survey
#20
Sandra C Jones, Laura Robinson, Lance Barrie, Kate Francis, Jeong Kyu Lee
AIMS: To examine the association of alcohol-brand social networking pages and Facebook users' drinking attitudes and behaviours. METHODS: Cross-sectional, self-report data were obtained from a convenience sample of 283 Australian Facebook users aged 16-24 years via an online survey. RESULTS: More than half of the respondents reported using Facebook for more than an hour daily. While only 20% had actively interacted with an alcohol brand on Facebook, we found a significant association between this active interaction and alcohol consumption, and a strong association between engagement with alcohol brands on Facebook and problematic drinking...
July 2016: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
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