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JOURNAL ARTICLE
Houreratou Barry, Edouard Lhomme, Mathieu Surénaud, Moumini Nouctara, Cynthia Robinson, Viki Bockstal, Innocent Valea, Serge Somda, Halidou Tinto, Nicolas Meda, Brian Greenwood, Rodolphe Thiébaut, Christine Lacabaratz
BACKGROUND: The exposure to parasites may influence the immune response to vaccines in endemic African countries. In this study, we aimed to assess the association between helminth exposure to the most prevalent parasitic infections, schistosomiasis, soil transmitted helminths infection and filariasis, and the Ebola virus glycoprotein (EBOV GP) antibody concentration in response to vaccination with the Ad26.ZEBOV, MVA-BN-Filo vaccine regimen in African and European participants using samples obtained from three international clinical trials...
April 11, 2024: PLoS Neglected Tropical Diseases
#2
JOURNAL ARTICLE
Hamid Ehsan, Myra Robinson, Peter M Voorhees, Kristen Cassetta, Shanice Borden, Shebli Atrash, Manisha Bhutani, Cindy Varga, Mauricio Pineda-Roman, Reed Friend, Barry A Paul
Selinexor (Seli) is a first-in-class, oral selective inhibitor of the nuclear export protein, exportin-1 (XPO1). Seli exhibits its antitumor effect through the blockage of XPO1, which increases nuclear retention of tumor suppressor proteins (TSPs), including p53, thereby limiting the translation of oncogenes, triggering cell cycle arrest and the death of malignant cells. Multiple Myeloma (MM) patients with del17p are deficient in TP53 and have a particularly poor prognosis. Given its unique mechanism of action, we investigated whether Seli has increased efficacy in RRMM patients with del17p compared to other high-risk cytogenetics (OHRC)...
March 14, 2024: Life
#3
JOURNAL ARTICLE
Barry W Neun, Timothy M Potter, Christina Robinson, Simone Difilippantonio, Elijah Edmondson, Marina A Dobrovolskaia
Autoimmune responses are characterized by the presence of antibodies and lymphocytes specific to self or so-called autoantigens. Among such autoantigens is DNA; therefore, screening for antibodies recognizing single- and/or double-stranded DNA is commonly used to detect and classify autoimmune diseases. While autoimmunity affects both sexes, females are generally more affected than males, which is recapitulated in some animal models. A variety of factors, including genetic predisposition and the environment, contribute to the development of autoimmune disorders...
2024: Methods in Molecular Biology
#4
JOURNAL ARTICLE
Barry Setlow, Matthew R Burns
No abstract text is available yet for this article.
March 12, 2024: Cognitive, Affective & Behavioral Neuroscience
#5
JOURNAL ARTICLE
Peter Y F Zeng, Stephenie D Prokopec, Stephen Y Lai, Nicole Pinto, Michelle A Chan-Seng-Yue, Roderick Clifton-Bligh, Michelle D Williams, Christopher J Howlett, Paul Plantinga, Matthew J Cecchini, Alfred K Lam, Iram Siddiqui, Jianxin Wang, Ren X Sun, John D Watson, Reju Korah, Tobias Carling, Nishant Agrawal, Nicole Cipriani, Douglas Ball, Barry Nelkin, Lisa M Rooper, Justin A Bishop, Cathie Garnis, Ken Berean, Norman G Nicolson, Paul Weinberger, Ying C Henderson, Christopher M Lalansingh, Mao Tian, Takafumi N Yamaguchi, Julie Livingstone, Adriana Salcedo, Krupal Patel, Frederick Vizeacoumar, Alessandro Datti, Liu Xi, Yuri E Nikiforov, Robert Smallridge, John A Copland, Laura A Marlow, Martin D Hyrcza, Leigh Delbridge, Stan Sidhu, Mark Sywak, Bruce Robinson, Kevin Fung, Farhad Ghasemi, Keith Kwan, S Danielle MacNeil, Adrian Mendez, David A Palma, Mohammed I Khan, Mushfiq Shaikh, Kara M Ruicci, Bret Wehrli, Eric Winquist, John Yoo, Joe S Mymryk, James W Rocco, David Wheeler, Steve Scherer, Thomas J Giordano, John W Barrett, William C Faquin, Anthony J Gill, Gary Clayman, Paul C Boutros, Anthony C Nichols
Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated thyroid cancers, yet the molecular origins of its aggressivity are unknown. We sequenced tumor DNA from 329 regions of thyroid cancer, including 213 from patients with primary anaplastic thyroid carcinomas. We also whole genome sequenced 9 patients using multi-region sequencing of both differentiated and anaplastic thyroid cancer components. Using these data, we demonstrate thatanaplastic thyroid carcinomas have a higher burden of mutations than other thyroid cancers, with distinct mutational signatures and molecular subtypes...
February 26, 2024: Cell Reports
#6
JOURNAL ARTICLE
Adeep Puri, Andrew J Pollard, Catherine Schmidt-Mutter, Fabrice Lainé, George PrayGod, Hannah Kibuuka, Houreratou Barry, Jean-François Nicolas, Jean-Daniel Lelièvre, Sodiomon Bienvenu Sirima, Beatrice Kamala, Daniela Manno, Deborah Watson-Jones, Auguste Gaddah, Babajide Keshinro, Kerstin Luhn, Cynthia Robinson, Macaya Douoguih
In this prospective, observational study (ClinicalTrials.gov Identifier: NCT02661464), long-term safety information was collected from participants previously exposed to the Ebola vaccines Ad26.ZEBOV and/or MVA-BN-Filo while enrolled in phase 1, 2, or 3 clinical studies. The study was conducted at 15 sites in seven countries (Burkina Faso, France, Kenya, Tanzania, Uganda, the United Kingdom, and the United States). Adult participants and offspring from vaccinated female participants who became pregnant (estimated conception ≤28 days after vaccination with MVA-BN-Filo or ≤3 months after vaccination with Ad26...
February 17, 2024: Vaccines
#7
Kelly K Barry, Julie S Kranseler, Sarah N Robinson
STING-associated vasculopathy with onset in infancy (SAVI) is a rare, monogenic interferonopathy caused by gain-of-function variants in STING1 (TMEM173) characterized by systemic inflammation, cutaneous vasculopathy, and interstitial lung disease. We report a case of SAVI attributed to a novel STING1 p.R284T variant who demonstrated characteristic cutaneous features including telangiectasias, livedo and acrocyanotic changes on face and extremities, as well as saddle nose deformity, failure to thrive, inflammatory arthritis and notable lack of pulmonary disease or autoantibody positivity...
February 18, 2024: Pediatric Dermatology
#8
JOURNAL ARTICLE
Íde O'Shaughnessy, Katie Robinson, Aoife Whiston, Louise Barry, Gillian Corey, Collette Devlin, Deirdre Hartigan, Aoife Synnott, Aoife McCarthy, Eoin Moriarty, Bryan Jones, Ida Carroll, Denys Shchetkovsky, Margaret O'Connor, Fiona Steed, Leonora Carey, Mairéad Conneely, Aoife Leahy, Colin Quinn, Elaine Shanahan, Damien Ryan, Rose Galvin
BACKGROUND: This study aimed to explore the process, clinical, and patient-reported outcomes of older adults who received an interdisciplinary Comprehensive Geriatric Assessment (CGA) in the emergency department (ED) over a six-month period after their initial ED attendance. PATIENTS AND METHODS: A prospective cohort study recruited older adults aged ≥65 years who presented to the ED of a university teaching hospital in Ireland. Baseline assessment data comprising a battery of demographic variables and validated indices were obtained at the index ED attendance...
2024: Clinical Interventions in Aging
#9
JOURNAL ARTICLE
Azwidihwi Takalani, Michelle Robinson, Phumeza Jonas, Annie Bodenstein, Vuyelo Sambo, Barry Jacobson, Vernon Louw, Jessica Opie, Jonny Peter, Pradeep Rowji, Ishen Seocharan, Tarylee Reddy, Nonhlanhla Yende-Zuma, Kentse Khutho, Ian Sanne, Linda-Gail Bekker, Glenda Gray, Nigel Garrett, Ameena Goga
The Sisonke 2 study provided a homologous boost at least 6 months after administration of the priming dose of Ad26.COV2.S for healthcare workers enrolled on the Sisonke phase 3b implementation study. Safety monitoring was via five reporting sources: (i.) self-report through a web-link; (ii.) paper-based case report forms; (iii.) a toll-free telephonic reporting line; (iv.) healthcare professionals-initiated reports; and (v.) active linkage with National Disease Databases. A total of 2350 adverse events were reported by 2117 of the 240 888 (0...
January 25, 2024: Vaccine
#10
JOURNAL ARTICLE
Elena B Hawryluk, Danna Moustafa, Kelly K Barry, Eman Bahrani, Diana B Reusch, Meera Brahmbhatt, Lily Chen, Carrie C Coughlin, Pedram Gerami, Ellen Haddock, Kristen Hook, Stephen R Humphrey, Pei-Chi Kao, Lacey L Kruse, Leslie P Lawley, Danny Mansour, Ashfaq A Marghoob, Julie Nguyen, Thuy L Phung, Elena Pope, Tom Raisanen, Sarah Robinson, Tova Rogers, Birgitta Schmidt, Gary Tran, Kate Travis, Zachary Wolner, Wendy B London, Lawrence F Eichenfield, Jennifer Huang
BACKGROUND: Pediatric melanoma presents with distinct clinical features compared to adult disease. OBJECTIVE: Characterize risk factors and negative outcomes in pediatric melanoma. METHODS: Multicenter retrospective study of patients under 20 years diagnosed with melanoma between 1/1/1995 - 6/30/2015 from 11 academic medical centers. RESULTS: Melanoma was diagnosed in 317 patients, 73% of whom were diagnosed in adolescence (age ≥11)...
November 29, 2023: Journal of the American Academy of Dermatology
#11
Mamadu Baldeh, Samuel Kizito, Sulaiman Lakoh, Daniel Sesay, Frida Dennis, Umu Barrie, Samuel Adeyemi Williams, Dimbintsoa Rakotomalala Robinson, Franck Lamontagne, Franck Amahowe, Patrick Turay, Ozge Sensory-Bahar, Elvin Geng, Fred M Ssewamala
BACKGROUND: Advanced HIV in young people living with HIV is an increasingly pressing public health issue in sub-Saharan Africa. Despite global progress in early HIV testing and reducing HIV-related deaths, many young people with HIV continue to experience HIV disease progression in sub-Saharan Africa. This study provides an overview of the prevalence, clinical manifestations, and factors associated with advanced HIV in young people seeking medical services in a major hospital in Sierra Leone...
November 8, 2023: medRxiv
#12
RANDOMIZED CONTROLLED TRIAL
Mairéad Conneely, Siobhán Leahy, Margaret O'Connor, Gillian Corey, Ahmed Gabr, Anastasia Saleh, Blessing Okpaje, Íde O' Shaughnessy, Aoife Synnott, Aoife McCarthy, Alison Holmes, Katie Robinson, Lorna Ryan, Anne Griffin, Louise Barry, Dominic Trépel, Damian Ryan, Rose Galvin
BACKGROUND: Older adults frequently attend the emergency department (ED) and experience high rates of subsequent adverse outcomes including functional decline, ED re-presentation and unplanned hospital admission. The development of effective interventions to prevent such outcomes is a key priority for research and service provision. Our aim was to evaluate the feasibility of a physiotherapy-led integrated care intervention for older adults discharged from the ED (ED PLUS). PATIENTS AND METHODS: Older adults presenting to the ED of a university teaching hospital with undifferentiated medical complaints and discharged within 72 hours were computer randomised in a ratio of 1:1:1 to deliver usual care, Comprehensive Geriatric Assessment (CGA) in the ED, or ED PLUS...
2023: Clinical Interventions in Aging
#13
JOURNAL ARTICLE
Íde O'Shaughnessy, Christine Fitzgerald, Aoife Whiston, Patrick Harnett, Helen Whitty, Des Mulligan, Marian Mullaney, Catherine Devaney, Deirdre Lang, Jennifer Hardimann, Brian Condon, Christina Hayes, Alison Holmes, Louise Barry, Claire McCormack, Megan Bounds, Katie Robinson, Margaret O'Connor, Damien Ryan, Denys Shchetkovsky, Fiona Steed, Leonora Carey, Emer Ahern, Rose Galvin
BACKGROUND: Innovations in models of care for older adults living with frailty presenting to the emergency department (ED) have become a key priority for clinicians, researchers and policymakers due to the deleterious outcomes older adults experience due to prolonged exposure to such an environment. This study aimed to develop a set of expert consensus-based statements underpinning operational design, outcome measurement and evaluation of a Frailty at the Front Door (FFD) model of care for older adults within an Irish context...
October 20, 2023: BMC Emergency Medicine
#14
JOURNAL ARTICLE
Rachel Mason, Gill Barry, Hugh Robinson, Ben O'Callaghan, Oisín Lennon, Alan Godfrey, Samuel Stuart
OBJECTIVE: Gait assessments have traditionally been analysed in laboratory settings, but this may not reflect natural gait. Wearable technology may offer an alternative due to its versatility. The purpose of the study was to establish the validity and reliability of temporal gait outcomes calculated by the DANU Sports System, against a 3D motion capture reference system. APPROACH: Forty-one healthy adults (26M, 15F, age 36.4 ± 11.8 years) completed a series of overground walking and jogging trials and 60s treadmill walking and running trials at various speeds (8-14km/hr), participants returned for a second testing session to repeat the same testing...
October 18, 2023: Physiological Measurement
#15
JOURNAL ARTICLE
Reid Longley, Aaron Robinson, Julian A Liber, Abigail E Bryson, Demosthenes P Morales, Kurt LaButti, Robert Riley, Stephen J Mondo, Alan Kuo, Yuko Yoshinaga, Chris Daum, Kerrie Barry, Igor V Grigoriev, Alessandro Desirò, Patrick S G Chain, Gregory Bonito
Diverse members of early-diverging Mucoromycota, including mycorrhizal taxa and soil-associated Mortierellaceae, are known to harbor Mollicutes-related endobacteria (MRE). It has been hypothesized that MRE were acquired by a common ancestor and transmitted vertically. Alternatively, MRE endosymbionts could have invaded after the divergence of Mucoromycota lineages and subsequently spread to new hosts horizontally. To better understand the evolutionary history of MRE symbionts, we generated and analyzed four complete MRE genomes from two Mortierellaceae genera: Linnemannia (MRE-L) and Benniella (MRE-B)...
September 18, 2023: Communications Biology
#16
JOURNAL ARTICLE
Craig Flannigan, Mark Robinson, Nidia Rodriguez-Sanchez, Barry Drust, Ruairidh McGregor, Stuart Galloway
This study investigates variations in skinfold thickness in a European professional football team within and across multiple seasons, including before and after COVID-19 restrictions. Skinfold thickness was measured in 49 male players on 32 occasions across three seasons (2018/19, 2019/20 and 2020/21). Intra- and inter-seasonal trends were examined by comparing values for the sum of eight skinfolds (sum8) at key time points using linear mixed models. In each season, the largest differences in sum8 occurred after the preseason period...
August 22, 2023: Science & medicine in football
#17
JOURNAL ARTICLE
Jenni Naisby, Gemma Wilson-Menzfeld, Katherine Baker, Rosie Morris, Jonathan Robinson, Gill Barry
BACKGROUND: Physical activity is encouraged for people with Multiple Sclerosis. Yoga is a popular form of physical activity and is chosen by some people with Multiple Sclerosis. However, little is known about the impact of yoga for this population, alongside what influences ongoing engagement. AIM: The aim of this study is to qualitatively explore the impact of online home-based yoga on people with Multiple Sclerosis and to explore factors that influence engagement...
2023: PloS One
#18
JOURNAL ARTICLE
Shebli Atrash, Myra Robinson, Alankrita Taneja, Barry Paul, Kristen Cassetta, Ami Ndiaye, Cindy Varga, Jared Block, Edward H Lipford, Elton T Smith, Chad M McCall, Virginia Thurston, David Foureau, Saad Z Usmani, Peter M Voorhees, Manisha Bhutani
BACKGROUND: Ki-67 is an index of proliferative activity and is an established predictive and prognostic marker in multiple malignancies. However, its prognostic relevance in multiple myeloma (MM) is unclear. We investigated the relationship between Ki-67 expression and survival outcomes in MM in the era of novel therapies. METHODS: We interrogated our database to identify patients with MM, newly diagnosed between July 1, 2013 and December 31, 2020, with Ki-67 expression assessed by immunohistochemistry (IHC) on bone marrow biopsies...
June 13, 2023: European Journal of Haematology
#19
JOURNAL ARTICLE
Manisha Bhutani, David M Foureau, Myra Robinson, Fei Guo, Kateryna Fesenkova, Shebli Atrash, Barry Paul, Cindy Varga, Reed Friend, Mauricio Pineda-Roman, Katherine Rigby, James T Symanowski, Sarah Norek, Mallory R Tucker, Lawrence J Druhan, Peter M Voorhees, Saad Z Usmani
INTRODUCTION: Treatment of patients with multiple myeloma (MM) in first relapse remains a challenge. This phase II study combined elotuzumab (Elo) with carfilzomib, lenalidomide, and dexamethasone (KRd) for treatment of MM in first relapse with the aim of improving efficacy. METHODS: Enrolled patients received Elo-KRd induction for 4 cycles, and Elo-lenalidomide maintenance until progression. The primary endpoint was VGPR or better (≥VGPR) postinduction. Secondary endpoints were MRD by flow cytometry, OS, PFS, and safety...
April 7, 2023: Clinical Lymphoma, Myeloma & Leukemia
#20
JOURNAL ARTICLE
Chelsea McLean, Houreratou Barry, Mark Kieh, Zacchaeus Anywaine, Baimba Tapima Rogers, Seydou Doumbia, Sodiomon B Sirima, Alimamy Serry-Bangura, Abdoul Habib Beavogui, Auguste Gaddah, Michael Katwere, Jenny Hendriks, Babajide Keshinro, Serge Eholie, Hannah Kibuuka, Stephen B Kennedy, Omu Anzala, Mohamed Samai, Eric D'Ortenzio, Bailah Leigh, Samba Sow, Rodolphe Thiébaut, Brian Greenwood, Deborah Watson-Jones, Macaya Douoguih, Kerstin Luhn, Cynthia Robinson
BACKGROUND: This analysis evaluated the immune response to the two-dose, heterologous Ad26.ZEBOV, MVA-BN-Filo Ebola virus vaccine regimen, administered 56-days apart, from multiple African sites based on results from one analytic laboratory. METHODS: Immunogenicity across three trials (EBL2002, EBL2004/PREVAC, EBL3001) conducted in East and West Africa is summarised. Vaccine-induced Ebola glycoprotein-binding antibody concentrations were analysed by Q2 Solutions laboratory at baseline, 21 days (EBL2002 and EBL3001) or 28 days (EBL2004) post-dose 2 (regimen completion), and 12 months post-dose 1 using the validated Filovirus Animal Nonclinical Group Ebola glycoprotein enzyme-linked immunosorbent assay (ELISA)...
April 24, 2023: EBioMedicine
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