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barrie Robinson

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https://www.readbyqxmd.com/read/28716555/attitudes-about-vaccines-to-prevent-ebola-virus-disease-in-guinea-at-the-end-of-a-large-ebola-epidemic-results-of-a-national-household-survey
#1
Kathleen L Irwin, Mohamed F Jalloh, Jamaica Corker, Barry Alpha Mahmoud, Susan J Robinson, Wenshu Li, Nyuma E James, Musa Sellu, Mohammad B Jalloh, Alpha Ahmadou Diallo, LaRee Tracy, Rana Hajjeh, Amanda VanSteelandt, Rebecca Bunnell, Lise Martel, Pratima L Raghunathan, Barbara Marston
INTRODUCTION: In 2014-2016, an Ebola epidemic devastated Guinea; more than 3800 cases and 2500 deaths were reported to the World Health Organization. In August 2015, as the epidemic waned and clinical trials of an experimental, Ebola vaccine continued in Guinea and neighboring Sierra Leone, we conducted a national household survey about Ebola-related knowledge, attitudes, and practices (KAP) and opinions about "hypothetical" Ebola vaccines. METHODS: Using cluster-randomized sampling, we selected participants aged 15+ years old in Guinea's 8 administrative regions, which had varied cumulative case counts...
July 14, 2017: Vaccine
https://www.readbyqxmd.com/read/28594962/effects-of-bilateral-anterior-agranular-insula-lesions-on-food-anticipatory-activity-in-rats
#2
Alex M Gavrila, Suzanne Hood, Barry Robinson, Shimon Amir
Food anticipatory activity (FAA) refers to a daily rhythm of locomotor activity that emerges under conditions of food restriction, whereby animals develop an intense, predictable period of activity in the few hours leading up to a predictable, daily delivery of food. The neural mechanisms by which FAA is regulated are not yet fully understood. Although a number of brain regions appear to be involved in regulating the development and expression of FAA, there is little evidence to date concerning the role of the anterior agranular insular cortex (AICa)...
2017: PloS One
https://www.readbyqxmd.com/read/28472989/circulating-mutational-portrait-of-cancer-manifestation-of-aggressive-clonal-events-in-both-early-and-late-stages
#3
Meng Yang, Umit Topaloglu, W Jeffrey Petty, Matthew Pagni, Kristie L Foley, Stefan C Grant, Mac Robinson, Rhonda L Bitting, Alexandra Thomas, Angela T Alistar, Rodwige J Desnoyers, Michael Goodman, Carol Albright, Mercedes Porosnicu, Mihaela Vatca, Shadi A Qasem, Barry DeYoung, Ville Kytola, Matti Nykter, Kexin Chen, Edward A Levine, Edgar D Staren, Ralph B D'Agostino, Robin M Petro, William Blackstock, Bayard L Powell, Edward Abraham, Boris Pasche, Wei Zhang
BACKGROUND: Solid tumors residing in tissues and organs leave footprints in circulation through circulating tumor cells (CTCs) and circulating tumor DNAs (ctDNA). Characterization of the ctDNA portraits and comparison with tumor DNA mutational portraits may reveal clinically actionable information on solid tumors that is traditionally achieved through more invasive approaches. METHODS: We isolated ctDNAs from plasma of patients of 103 lung cancer and 74 other solid tumors of different tissue origins...
May 4, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28396475/assessments-of-ebola-knowledge-attitudes-and-practices-in-for%C3%A3-cariah-guinea-and-kambia-sierra-leone-july-august-2015
#4
Mohamed F Jalloh, Rebecca Bunnell, Susan Robinson, Mohammad B Jalloh, Alpha Mamoudou Barry, Jamaica Corker, Paul Sengeh, Amanda VanSteelandt, Wenshu Li, Foday Dafae, Alpha Ahmadou Diallo, Lise D Martel, Sara Hersey, Barbara Marston, Oliver Morgan, John T Redd
The border region of Forécariah (Guinea) and Kambia (Sierra Leone) was of immense interest to the West Africa Ebola response. Cross-sectional household surveys with multi-stage cluster sampling procedure were used to collect random samples from Kambia (n = 635) in July 2015 and Forécariah (n = 502) in August 2015 to assess public knowledge, attitudes and practices related to Ebola. Knowledge of the disease was high in both places, and handwashing with soap and water was the most widespread prevention practice...
May 26, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28298955/the-apolipoprotein-l1-gene-and-cardiovascular-disease
#5
REVIEW
Todd W Robinson, Barry I Freedman
Relative to those with European ancestry, African Americans have an excess incidence of nondiabetic chronic kidney disease predominantly due to two coding renal-risk variants in the apolipoprotein L1 gene (APOL1). This APOL1-kidney disease association is independent of systemic hypertension or blood pressure. Recent reports describe extra-renal effects of the APOL1 G1 and G2 renal-risk variants on cardiovascular disease (CVD), subclinical atherosclerosis, lipoprotein particle concentrations, and survival. However, results have been less consistent than those seen in kidney disease, and the observed APOL1 associations with CVD vary from risk to protective...
October 2016: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/28283992/training-load-monitoring-in-team-sports-a-novel-framework-separating-physiological-and-biomechanical-load-adaptation-pathways
#6
Jos Vanrenterghem, Niels Jensby Nedergaard, Mark A Robinson, Barry Drust
There have been considerable advances in monitoring training load in running-based team sports in recent years. Novel technologies nowadays offer ample opportunities to continuously monitor the activities of a player. These activities lead to internal biochemical stresses on the various physiological subsystems; however, they also cause internal mechanical stresses on the various musculoskeletal tissues. Based on the amount and periodization of these stresses, the subsystems and tissues adapt. Therefore, by monitoring external loads, one hopes to estimate internal loads to predict adaptation, through understanding the load-adaptation pathways...
March 10, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28143671/apol1-gene-kidney-risk-variants-and-cardiovascular-disease-getting-to-the-heart-of-the-matter
#7
REVIEW
Nicholas O McLean, Todd W Robinson, Barry I Freedman
Apolipoprotein L1 gene (APOL1) renal risk variants exhibit strong genetic associations with a spectrum of nondiabetic kidney diseases in individuals with recent African ancestry. Relationships between APOL1 kidney risk variants and cardiovascular disease (CVD) susceptibility and CVD-related death remain controversial. Some studies detected an increased risk for CVD, whereas others support protection from death and subclinical CVD and cerebrovascular disease. Because treatments for nondiabetic kidney disease may target this gene and its protein products, it remains critical to clarify the potential extrarenal effects of APOL1 kidney risk variants...
August 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28087008/apol1-genotype-blood-pressure-and-survival-in-african-americans-with-nondiabetic-nephropathy
#8
Todd W Robinson, Barry I Freedman
Several landmark trials have assessed the effects of aggressive hypertension control on the progression of nondiabetic chronic kidney disease. Results generally have been disappointing. With the realization that lowering blood pressure, including with renin-angiotensin system blockade, failed to reliably prevent end-stage kidney disease, studies now are analyzing longer-term effects of hypertension control on survival in chronic kidney disease. This commentary reviews the current findings and extends the discussion to apolipoprotein L1 gene by blood pressure (or gene by environment) interactions...
February 2017: Kidney International
https://www.readbyqxmd.com/read/28064386/brief-supportive-expressive-group-therapy-for-partners-of-men-with-early-stage-prostate-cancer-lessons-learned-from-a-negative-randomized-controlled-trial
#9
Linda E Carlson, Codie R Rouleau, Michael Speca, John Robinson, Barry D Bultz
PURPOSE: The purpose of this paper is to report the results of a negative randomized controlled trial, which piloted brief supportive-expressive therapy (SET) for partners of men with prostate cancer, and to discuss lessons learned for future clinical trials. METHODS: Partners of men with newly diagnosed, non-metastatic prostate cancer were randomized to SET (n = 45) or usual care (n = 32). SET involved six weekly group sessions emphasizing emotional expression, social support, and finding meaning in the cancer experience...
January 7, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27780169/the-effects-of-carvedilol-on-cardiac-function-and-the-akt-xiap-signaling-pathway-in-diabetic-cardiomyopathy-rats
#10
Wencheng Zheng, Xiaoming Shang, Chunlai Zhang, Xiang Gao, Barry Robinson, Jing Liu
OBJECTIVES: Diabetic cardiomyopathy (DCM) is characterized by cardiac dysfunction, myocardial inflammation, interstitial fibrosis and cardiomyocytes apoptosis. The present study aimed to investigate the effects of carvedilol on cardiac function and the AKT/XIAP signaling pathway in DCM rats. METHODS: Male Wistar rats were randomly divided into 3 groups: the control group, diabetic mellitus (DM) group and DM with carvedilol treatment group. DM rats were induced by streptozotocin accompanied by high energy intake...
2017: Cardiology
https://www.readbyqxmd.com/read/27598850/mechanical-player-load%C3%A2-using-trunk-mounted-accelerometry-in-football-is-it-a-reliable-task-and-player-specific-observation
#11
Paulo Barreira, Mark A Robinson, Barry Drust, Niels Nedergaard, Raja Mohammed Firhad Raja Azidin, Jos Vanrenterghem
The aim of the present study was to examine reliability and construct convergent validity of Player Load™ (PL) from trunk-mounted accelerometry, expressed as a cumulative measure and an intensity measure (PL · min(-)(1)). Fifteen male participants twice performed an overground football match simulation that included four different multidirectional football actions (jog, side cut, stride and sprint) whilst wearing a trunk-mounted accelerometer inbuilt in a global positioning system unit. Results showed a moderate-to-high reliability as indicated by the intra-class correlation coefficient (0...
September 6, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27449787/cost-effectiveness-analysis-of-offering-free-leisure-centre-memberships-to-physically-inactive-members-of-the-public-receiving-state-benefits-a-case-study
#12
Talitha I Verhoef, Verena Trend, Barry Kelly, Nigel Robinson, Paul Fox, Stephen Morris
BACKGROUND: We evaluated the cost-effectiveness of the Give-it-a-Go programme, which offers free leisure centre memberships to physically inactive members of the public in a single London Borough receiving state benefits. METHODS: A decision analytic Markov model was developed to analyse lifetime costs and quality-adjusted life-years (QALYs) of 1025 people recruited to the intervention versus no intervention. In the intervention group, people were offered 4 months of free membership at a leisure centre...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27284213/improvements-in-cd-stable-isotope-analysis-achieved-through-use-of-liquid-liquid-extraction-to-remove-organic-residues-from-cd-separates-obtained-by-extraction-chromatography
#13
Katy Murphy, Mark Rehkämper, Katharina Kreissig, Barry Coles, Tina van de Flierdt
Organic compounds released from resins that are commonly employed for trace element separations are known to have a detrimental impact on the quality of isotopic analyses by MC-ICP-MS. A recent study highlighted that such effects can be particularly problematic for Cd stable isotope measurements (M. Gault-Ringold and C. H. Stirling, J. Anal. At. Spectrom., 2012, 27, 449-459). In this case, the final stage of sample purification commonly applies extraction chromatography with Eichrom TRU resin, which employs particles coated with octylphenyl-N,N-di-isobutyl carbamoylphosphine oxide (CMPO) dissolved in tri-n-butyl phosphate (TBP)...
January 23, 2016: Journal of Analytical Atomic Spectrometry
https://www.readbyqxmd.com/read/27079714/potentially-inappropriate-prescribing-among-people-with-dementia-in-primary-care-a-retrospective-cross-sectional-study-using-the-enhanced-prescribing-database
#14
Heather E Barry, Janine A Cooper, Cristín Ryan, A Peter Passmore, A Louise Robinson, Gerard J Molloy, Carmel M Darcy, Hilary Buchanan, Carmel M Hughes
BACKGROUND: Little is known about prescribing appropriateness for community-dwelling people with dementia (PWD). OBJECTIVE: To estimate potentially inappropriate prescribing (PIP) prevalence among PWD in primary care in Northern Ireland, and to investigate associations between PIP, polypharmacy, age, and gender. METHODS: A retrospective cross-sectional study was conducted, using data from the Enhanced Prescribing Database. Patients were eligible if a medicine indicated for dementia management was dispensed to them during 1 January 2013-31 December 2013...
April 11, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27076664/do-staphylococcus-epidermidis-genetic-clusters-predict-isolation-sources
#15
Isaiah Tolo, Jonathan C Thomas, Rebecca S B Fischer, Eric L Brown, Barry M Gray, D Ashley Robinson
Staphylococcus epidermidis is a ubiquitous colonizer of human skin and a common cause of medical device-associated infections. The extent to which the population genetic structure of S. epidermidis distinguishes commensal from pathogenic isolates is unclear. Previously, Bayesian clustering of 437 multilocus sequence types (STs) in the international database revealed a population structure of six genetic clusters (GCs) that may reflect the species' ecology. Here, we first verified the presence of six GCs, including two (GC3 and GC5) with significant admixture, in an updated database of 578 STs...
July 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27057778/normative-values-for-electrochemical-skin-conductances-and-impact-of-ethnicity-on-quantitative-assessment-of-sudomotor-function
#16
Aaron I Vinik, A Gordon Smith, J Robinson Singleton, Brian Callaghan, Barry I Freedman, Jaakko Tuomilehto, Lyse Bordier, Bernard Bauduceau, Frederic Roche
BACKGROUND: Sudomotor dysfunction is one of the earliest pathophysiologic abnormalities in diabetes. Sudoscan™ (Impeto Medical, Paris, France) was developed as a noninvasive, rapid, and quantitative assessment of sudomotor function and has been shown to be sensitive in the detection of neuropathy. This global collaborative analysis aimed to establish reference values in healthy subjects of different ethnic groups, age, and gender, to define factors potentially affecting results, and to provide standardization of the methodology...
June 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27040285/risk-stratification-of-childhood-medulloblastoma-in-the-molecular-era-the-current-consensus
#17
Vijay Ramaswamy, Marc Remke, Eric Bouffet, Simon Bailey, Steven C Clifford, Francois Doz, Marcel Kool, Christelle Dufour, Gilles Vassal, Till Milde, Olaf Witt, Katja von Hoff, Torsten Pietsch, Paul A Northcott, Amar Gajjar, Giles W Robinson, Laetitia Padovani, Nicolas André, Maura Massimino, Barry Pizer, Roger Packer, Stefan Rutkowski, Stefan M Pfister, Michael D Taylor, Scott L Pomeroy
Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological variables pertaining to age, presence of metastases, extent of resection, histological subtypes and in some instances individual genetic aberrations such as MYC and MYCN amplification. In 2010, an international panel of experts established consensus defining four main subgroups of medulloblastoma (WNT, SHH, Group 3 and Group 4) delineated by transcriptional profiling. This has led to the current generation of biomarker-driven clinical trials assigning WNT tumors to a favorable prognosis group in addition to clinicopathological criteria including MYC and MYCN gene amplifications...
June 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/27002795/the-relationship-between-whole-body-external-loading-and-body-worn-accelerometry-during-team-sport-movements
#18
Niels J Nedergaard, Mark A Robinson, Elena Eusterwiemann, Barry Drust, Paulo J Lisboa, Jos Vanrenterghem
PURPOSE: To investigate the relationship between whole-body accelerations and body-worn accelerometry during team-sport movements. METHODS: Twenty male team-sport players performed forward running and anticipated 45° and 90° side-cuts at approach speeds of 2, 3, 4, and 5 m/s. Whole-body center-of-mass (CoM) accelerations were determined from ground-reaction forces collected from 1 foot-ground contact, and segmental accelerations were measured from a commercial GPS accelerometer unit on the upper trunk...
January 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/26912495/where-people-shop-is-not-associated-with-the-nutrient-quality-of-packaged-foods-for-any-racial-ethnic-group-in-the-united-states
#19
Dalia Stern, Jennifer M Poti, Shu Wen Ng, Whitney R Robinson, Penny Gordon-Larsen, Barry M Popkin
BACKGROUND: In the literature, it has been suggested that there are race-ethnic disparities in what Americans eat. In addition, some studies have shown that residents of African American and low-income neighborhoods have less access to grocery stores and supermarkets, which tend to stock healthier foods. However, it is unclear whether differences in food shopping patterns contribute to the poorer nutrient profile of food purchases made by racial-ethnic minorities. OBJECTIVES: We examined whether the mix of food stores where people shop (i...
April 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/26792595/genetic-susceptibility-loci-of-idiopathic-interstitial-pneumonia-do-not-represent-risk-for-systemic-sclerosis-a-case-control-study-in-caucasian-patients
#20
Minghua Wu, Shervin Assassi, Gloria A Salazar, Claudia Pedroza, Olga Y Gorlova, Wei V Chen, Julio Charles, Miranda L Taing, Kelley Liao, Fredrick M Wigley, Laura K Hummers, Ami A Shah, Monique Hinchcliff, Dinesh Khanna, Elena Schiopu, Kristine Phillips, Daniel E Furst, Virginia Steen, Murray Baron, Marie Hudson, Xiaodong Zhou, Janet Pope, Niall Jones, Peter Docherty, Nader A Khalidi, David Robinson, Robert W Simms, Richard M Silver, Tracy M Frech, Barri J Fessler, Marvin J Fritzler, Jerry A Molitor, Barbara M Segal, Malahat Movahedian, Javier Martín, John Varga, Maureen D Mayes
BACKGROUND: Systemic sclerosis (SSc)-related interstitial lung disease (ILD) has phenotypic similarities to lung involvement in idiopathic interstitial pneumonia (IIP). We aimed to assess whether genetic susceptibility loci recently identified in the large IIP genome-wide association studies (GWASs) were also risk loci for SSc overall or severity of ILD in SSc. METHODS: A total of 2571 SSc patients and 4500 healthy controls were investigated from the US discovery GWAS and additional US replication cohorts...
January 20, 2016: Arthritis Research & Therapy
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