Heleen Gastmans, Erwin Dreesen, Sebastian G Wicha, Nada Dia, Ellen Spreuwers, Annabel Dompas, Karel Allegaert, Stefanie Desmet, Katrien Lagrou, Willy E Peetermans, Yves Debaveye, Isabel Spriet, Matthias Gijsen
We aimed to evaluate the predictive performance and predicted doses of a single-model approach or several multi-model approaches compared with the standard therapeutic drug monitoring (TDM)-based vancomycin dosing. We performed a hospital-wide monocentric retrospective study in adult patients treated with either intermittent or continuous vancomycin infusions. Each patient provided two randomly selected pairs of two consecutive vancomycin concentrations. A web-based precision dosing software, TDMx, was used to evaluate the model-based approaches...
July 13, 2022: Pharmaceutics