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Vancomycin continuous infusion

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https://www.readbyqxmd.com/read/27850317/678-prospective-evaluation-of-a-continuous-infusion-vancomycin-nomogram-in-icu-patients-receiving-cvvh
#1
Jonathan Sin, Kelly Newman, Hsin Lin
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27631462/pediatric-patients-with-solid-or-hematological-tumor-disease-vancomycin-population-pharmacokinetics-and-dosage-optimization
#2
Romain Guilhaumou, Amélie Marsot, Julien Dupouey, Claire Galambrun, Audrey Boulamery, Carole Coze, Nicolas Simon, Nicolas André
BACKGROUND: In pediatric cancer patients, determination of optimal vancomycin dosage is essential because of high risk of inadequate concentrations and bacterial resistance. The aim of this study was to determine vancomycin pharmacokinetic parameters in this population and propose dosage optimization to achieve optimal concentration. METHODS: We retrospectively reviewed the use of vancomycin in pediatric cancer patients with febrile neutropenia (hematological or solid tumor disease)...
October 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27540238/an-audit-of-vancomycin-plasma-concentrations-when-vancomycin-is-administered-by-continuous-intravenous-infusion-in-neonates
#3
Louise Whitticase, Gemma Holder, Matt Cawsey, Alison Bedford-Russell
AIM: To compare continuous intravenous infusions of vancomycin in achieving desired therapeutic plasma concentrations against an intermittent bolus regimen. METHOD: Data were collected for all babies who received a continuous infusion of vancomycin on our Neonatal Intensive Care Unit (NICU) between October 2014 and March 2015. The regimen is based on that of another hospital (Hospital A) and comprised of a loading dose of 15 mg/kg over 1 hour followed by a continuous infusion of 20-50 mg/kg/day according to creatinine and corrected gestational age (CGA)...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27540188/an-audit-of-paediatric-vancomycin-dosing
#4
Soomal Mohsin-Shaikh, Poonam Lumb
AIM: To audit whether a new paediatric vancomycin guideline is being adhered to and if therapeutic levels are being achieved. METHOD: Data on doses, age, weight, vancomycin levels, time taken and renal function were collected prospectively by reviewing drug charts of paediatric patients on vancomycin. The patients were followed for their whole vancomycin journey in order to observe if the guidelines were followed throughout. Data were collected between 7th and 30th January 2015...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27432414/evaluation-of-pharmacodynamic-interactions-between-telavancin-and-aztreonam-or-piperacillin-tazobactam-against-pseudomonas-aeruginosa-escherichia-coli-and-methicillin-resistant-staphylococcus-aureus
#5
Juwon Yim, Jordan R Smith, Katie E Barber, Jessica A Hallesy, Michael J Rybak
INTRODUCTION: In clinical trials comparing telavancin (TLV) with vancomycin for treatment of hospital-acquired pneumonia, TLV demonstrated lower clinical cure rates than vancomycin in patients who had mixed gram-positive and -negative infections and were concomitantly treated with either aztreonam (ATM) or piperacillin/tazobactam (PTZ). Here, we investigated therapeutic interactions between TLV and ATM or PTZ in an in vitro pharmacokinetic/pharmacodynamic (PK/PD) model under simulated reduced renal function conditions...
September 2016: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/27410410/drug-incompatibilities-in-the-adult-intensive-care-unit-of-a-university-hospital
#6
Naiane Roveda Marsilio, Daiandy da Silva, Denise Bueno
OBJECTIVES: This study sought to identify the physical and chemical incompatibilities among the drugs administered intravenously to patients admitted to an adult intensive care unit. We also aimed to establish pharmaceutical guidelines for administering incompatible drugs. METHODS: This cross-sectional, prospective, and quantitative study was conducted from July to September 2015. Drug incompatibilities were identified based on an analysis of the patient prescriptions available in the hospital online management system...
June 2016: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/27363312/daily-vancomycin-dose-requirements-as-a-continuous-infusion-in-obese-versus-non-obese-sicu-patients
#7
Hsin Lin, Daniel Dante Yeh, Alexander R Levine
BACKGROUND: Limited data are available assessing vancomycin concentrations in obese critically ill patients. Currently, there are no studies evaluating dosing requirements in this population who receive vancomycin administered as a continuous infusion (CI). The aim of this study was to assess whether there was a difference in the weight-based maintenance dose required to reach a therapeutic vancomycin concentration at 24 hours when given as a CI in obese versus non-obese critically ill patients...
2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27290207/predictors-of-acute-kidney-injury-under-continuous-infusion-of-vancomycin-in-critically-ill-surgical-patients
#8
R Chackupurakal, J Reessing, F Wappler, S G Sakka
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27216073/new-regimen-for-continuous-infusion-of-vancomycin-in-critically-ill-patients
#9
Stefano Cristallini, Maya Hites, Hakim Kabtouri, Jason A Roberts, Marjorie Beumier, Frederic Cotton, Jeffrey Lipman, Frédérique Jacobs, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone
Despite the development of new agents with activity against Gram-positive bacteria, vancomycin remains one of the primary antibiotics for critically ill septic patients. Because sepsis can alter antimicrobial pharmacokinetics, the development of an appropriate dosing strategy to provide adequate concentrations is crucial. The aim of this study was to prospectively validate a new dosing regimen of vancomycin given by continuous infusion (CI) to septic patients. We included all adult septic patients admitted to a mixed intensive care unit (ICU) between January 2012 and May 2013, who were treated with a new vancomycin CI regimen consisting of a loading dose of 35 mg/kg of body weight given as a 4-h infusion, followed by a daily CI dose adapted to creatinine clearance (CrCL), as estimated by the Cockcroft-Gault formula (median dose, 2,112 [1,500 to 2,838] mg)...
August 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27145210/the-antibioperf-study-a-nationwide-cross-sectional-survey-about-practices-for-%C3%AE-lactam-administration-and-therapeutic-drug-monitoring-among-critically-ill-patients-in-france
#10
A Charmillon, E Novy, N Agrinier, M Leone, A Kimmoun, B Levy, B Demoré, J Dellamonica, C Pulcini
Our objective was to assess current practices about the administration (intermittent, extended, or continuous infusions) and therapeutic drug monitoring (TDM) of β-lactam antibiotics and vancomycin in France. We conducted a nationwide cross-sectional survey in May-August 2015, using an online questionnaire, sent as an e-mail link to infectious disease specialists and intensive care specialists through national mailing lists. We used clinical vignettes of critically ill patients to assess physicians' practices about administration and TDM practices for amoxicillin, cloxacillin, piperacillin/tazobactam, cefotaxime, ceftazidime, cefepime, meropenem and vancomycin...
July 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27064954/the-impact-of-a-pilot-continuing-professional-development-module-on-hospital-pharmacists-preparedness-to-provide-contemporary-advice-on-the-clinical-use-of-vancomycin
#11
Cameron J Phillips, Alice J Wisdom, Vaughn S Eaton, Richard J Woodman, Ross A McKinnon
BACKGROUND: Revised international clinical guidelines for the antibiotic vancomycin have changed the advice pharmacists need to provide to medical and nursing colleagues. OBJECTIVES: (1) To determine the self-reported confidence of hospital pharmacists to provide contemporary advice on vancomycin and (2) to evaluate hospital pharmacists' knowledge to provide contemporary advice on vancomycin following a pilot continuing professional development (CPD) module. METHODS: The study was a prospective two-phase design in an Australian teaching hospital...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27037336/application-of-antibiotic-pharmacodynamics-and-dosing-principles-in-patients-with-sepsis
#12
Molly E Droege, Suzanne L Van Fleet, Eric W Mueller
Sepsis is associated with marked mortality, which may be reduced by prompt initiation of adequate, appropriate doses of antibiotic. Critically ill patients often have physiological changes that reduce blood and tissue concentrations of antibiotic and high rates of multidrug-resistant pathogens, which may affect patients' outcomes. All critical care professionals, including critical care nurses, should understand antibiotic pharmacokinetics and pharmacodynamics to ensure sound antibiotic dosing and administration strategies for optimal microbial killing and patients' outcomes...
April 2016: Critical Care Nurse
https://www.readbyqxmd.com/read/26997934/pharmacokinetics-of-continuous-infusion-meropenem-with-concurrent-extracorporeal-life-support-and-continuous-renal-replacement-therapy-a-case-report
#13
Jeffrey J Cies, Wayne S Moore, Susan B Conley, Mindy J Dickerman, Christine Small, Dominick Carella, Paul Shea, Jason Parker, Arun Chopra
Pharmacokinetic parameters can be significantly altered for both extracorporeal life support (ECLS) and continuous renal replacement therapy (CRRT). This case report describes the pharmacokinetics of continuous-infusion meropenem in a patient on ECLS with concurrent CRRT. A 2.8-kg, 10-day-old, full-term neonate born via spontaneous vaginal delivery presented with hypothermia, lethargy, and a ~500-g weight loss from birth. She progressed to respiratory failure on hospital day 2 (HD 2) and developed sepsis, disseminated intravascular coagulation, and liver failure as a result of disseminated adenoviral infection...
January 2016: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/26926670/switching-from-intermittent-to-continuous-infusion-of-vancomycin-in-critically-ill-patients-toward-a-more-robust-exposure
#14
Erik M van Maarseveen, Suzan Gipmans, Erwin Vasbinder, Manfred Petjak, Arthur R H van Zanten
BACKGROUND: To increase target attainment rates, switching the mode of administration from intermittent (InI) to continuous infusion (CoI) has been proposed. In this study, target attainment rates and interpatient variation in exposure were compared between vancomycin InI- and CoI-treated critically ill patients. METHODS: An observational cohort study was conducted among critically ill patients admitted to a level-2 intensive care unit. Adult patients (18 years or older) treated with intravenous vancomycin for various indications, including sepsis, pneumonia, and endocarditis between 2007 and 2013 were eligible for inclusion...
June 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/26890194/continuous-infusion-vancomycin-through-the-addition-of-vancomycin-to-the-continuous-renal-replacement-therapy-solution-in-the-picu-a-case-series
#15
Jeffrey J Cies, Wayne S Moore, Susan B Conley, Samina Muneeruddin, Jason Parker, Paul Shea, Arun Chopra
OBJECTIVES: To describe our experience with achieving therapeutic serum vancomycin concentrations in pediatric continuous renal replacement therapy by using continuous infusion vancomycin by mixing vancomycin into the continuous renal replacement therapy solution. DESIGN: Retrospective chart review. SETTING: A 189-bed, freestanding children's tertiary care teaching hospital in Philadelphia, PA. PATIENTS: Pediatric patients receiving continuous renal replacement therapy from April 1, 2009, through December 31, 2014...
April 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/26856841/optimizing-the-clinical-use-of-vancomycin
#16
REVIEW
Rocío Álvarez, Luis E López Cortés, José Molina, José M Cisneros, Jerónimo Pachón
The increasing number of infections produced by beta-lactam-resistant Gram-positive bacteria and the morbidity secondary to these infections make it necessary to optimize the use of vancomycin. In 2009, the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Disease Pharmacists published specific guidelines about vancomycin dosage and monitoring. However, these guidelines have not been updated in the past 6 years. This review analyzes the new available information about vancomycin published in recent years regarding pharmacokinetics and pharmacodynamics, serum concentration monitoring, and optimal vancomycin dosing in special situations (obese people, burn patients, renal replacement therapy, among others)...
May 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/26770686/a-specially-tailored-vancomycin-continuous-infusion-regimen-for-renally-impaired-critically-ill-patients
#17
Eman Mohamed Bahgat Eldemiry, Nirmeen A Sabry, Maggie M Abbassi, Sanaa S Abdel Shafy, Mohamed S Mokhtar, Ahmed Abdel Bary
BACKGROUND: Vancomycin remains the gold standard for treatment of methicillin-resistant Staphylococcus aureus. Specially designed continuous infusion of vancomycin leads to better therapy. METHODOLOGY: A total of 40 critically ill patients who suffered from pneumonia susceptible to vancomycin, had serum creatinine >1.4 mg%, and oliguria <0.5 mL/kg/h for 6 h were included in the study with respiratory culture sensitivity to vancomycin ≤2 mg/L. Patients' clinical, microbiological, and biological data were obtained by retrospective analysis of the corresponding medical files before and after vancomycin treatment...
2013: SAGE Open Medicine
https://www.readbyqxmd.com/read/26755499/pharmacodynamics-of-vancomycin-for-cons-infection-experimental-basis-for-optimal-use-of-vancomycin-in-neonates
#18
V Ramos-Martín, A Johnson, J Livermore, L McEntee, J Goodwin, S Whalley, F Docobo-Pérez, T W Felton, W Zhao, E Jacqz-Aigrain, M Sharland, M A Turner, W W Hope
OBJECTIVES: CoNS are the most common cause of neonatal late-onset sepsis. Information on the vancomycin pharmacokinetics/pharmacodynamics against CoNS is limited. The aim of this study was to characterize vancomycin pharmacokinetic/pharmacodynamic relationships for CoNS and investigate neonatal optimal dosage regimens. METHODS: A hollow fibre and a novel rabbit model of neonatal central line-associated bloodstream CoNS infections were developed. The results were then bridged to neonates by use of population pharmacokinetic techniques and Monte Carlo simulations...
April 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/26664398/effects-of-pharmacist-intervention-on-the-utilization-of-vancomycin-in-a-teaching-hospital
#19
Maria Tavakoli-Ardakani, Samaneh Ghassemi, Afshin Mohammad Alizadeh, Jamshid Salamzadeh, Mojtaba Ghadiani, Sara Ghassemi
In order to investigate the effect of pharmacist intervention on vancomycin use, this study was performed on all patients receiving vancomycin in the intensive care unit (ICU) and hematology-oncology ward of Taleghani Educational Hospital in Tehran, Iran. Vancomycin use was assessed during a pre- and post-intervention period in accordance with the Center of Disease Control and prevention (CDC) and Infectious Diseases Society of America (IDSA) guidelines. Following the intervention, there was a significant change in appropriate initiation of vancomycin (P = 0...
2015: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/26655032/continuous-versus-intermittent-infusion-of-vancomycin-in-adult-patients-a-systematic-review-and-meta-analysis
#20
REVIEW
Jing-Jing Hao, Han Chen, Jian-Xin Zhou
Continuous infusion of vancomycin (CIV) and intermittent infusion of vancomycin (IIV) are two major administration strategies in clinical settings. However, previous articles comparing the efficacy and safety of CIV versus IIV showed inconsistent results. Therefore, a meta-analysis was conducted to compare the efficacy and safety of CIV and IIV. PubMed, the Cochrane Library and Web of Science up to June 2015 were searched using the keywords 'vancomycin', 'intravenous', 'parenteral', 'continuous', 'intermittent', 'discontinuous', 'infusion', 'administration' and 'dosing'...
January 2016: International Journal of Antimicrobial Agents
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