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t cell activation ebstein barr virus

M Penel-Page, B Ben Said, A Phan, L Hees, C Hartmann-Merlin, S Girard, Y Gillet, A Belot
Hemophagocytic lymphohistiocytosis (HLH) is a rare and severe syndrome usually associated with a cytotoxicity deficiency, which leads to an excess of immune response driven by activated macrophages and cytotoxic T cells. In children, HLH can be genetic, as part of a familial lymphohistiocytosis, or secondary: the most frequent causes are systemic-onset juvenile idiopathic arthritis, hematological malignancies, and severe infections, especially with Ebstein-Barr virus or leishmaniosis. We report on the case of a 3-year-old girl with no past medical history, who presented inaugural Pseudomonas aeruginosa maxillary osteitis, with secondary HLH...
March 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Lissy de Ridder, Dan Turner, David C Wilson, Sibylle Koletzko, Javier Martin-de-Carpi, Ulrika L Fagerberg, Christine Spray, Malgorzata Sladek, Ron Shaoul, Eleftheria Roma-Giannikou, Jiri Bronsky, Daniela E Serban, Salvatore Cucchiara, Gabor Veres, Frank M Ruemmele, Iva Hojsak, Kaija L Kolho, Ieuan H Davies, Marina Aloi, Paolo Lionetti, Gigi Veereman-Wauters, Christian P Braegger, Eunice Trindade, Anne V Wewer, Almuthe Hauer, Arie Levine
BACKGROUND: The combination of the severity of pediatric-onset inflammatory bowel disease (IBD) phenotypes and the need for intense medical treatment may increase the risk of malignancy and mortality, but evidence regarding the extent of the problem is scarce. Therefore, the Porto Pediatric IBD working group of ESPGHAN conducted a multinational-based survey of cancer and mortality in pediatric IBD. METHODS: A survey among pediatric gastroenterologists of 20 European countries and Israel on cancer and/or mortality in the pediatric patient population with IBD was undertaken...
February 2014: Inflammatory Bowel Diseases
Se Ryeon Lee, Eun Kyung Park, Nam Hee Won, Byung Soo Kim
Esophageal involvement by extranodal natural killer (NK)/T cell lymphoma, nasal type, is rare. As a result, esophageal symptoms in these patients might at first be thought to originate from a benign condition, such as viral esophagitis. It is important to note, however, that benign conditions may mask esophageal involvement by lymphoma. Until now, there has been no report documenting esophageal involvement by lymphoma mimicking viral esophagitis in an extranodal NK/T cell lymphoma patient undergoing active treatment...
September 2010: Asia-Pacific Journal of Clinical Oncology
Maitreyee Bhattacharyya, M K Ghosh
Hemophagocytic lymphohistiocytosis is a rare condition characterized by highly stimulated but inactive immune response. The disease may be inherited or acquired due to infections, collagen vascular diseases and malignancies. The pathological hallmark of the syndrome is aggressive proliferation of macrophages and histiocytes. Decreased NK cell activity results in increased T cell activation resulting production of large quantities of interferon gamma (IFN gamma), tumor necrosis factor alpha (TNF alpha) and granulocyte macrophage colony stimulating factor (GM-CSF)...
June 2008: Journal of the Association of Physicians of India
Chong-yun Fang, Xiong-wen Wu, Zhi-hui Liang, Hao Chen, Jun-yan Han, Ya-fei Huang, Fei-li Gong
OBJECTIVE: To investigate the immune tolerance inducing effects of soluble human leucocyte antigen G1 (sHLA-G1) on natural killer (NK) cells and T cells. METHODS: A recombinant plasmid expressing sHLA-G1 was constructed and transfected into human lymphoblastoid cells LCL721.221. sHLA-G1 in the supernatant was purified by immuno-affinity chromatography and then added into the culture of NK cells obtained from the peripheral blood mononuclear cells of 3 unrelated individuals...
April 10, 2003: Zhonghua Yi Xue za Zhi [Chinese medical journal]
W M Schoell, R Mirhashemi, B Liu, M F Janicek, E R Podack, M A Penalver, H E Averette
OBJECTIVE: The aim of this study was to generate HPV-16 E7 peptide-specific cytotoxic T lymphocytes (CTLs) in vitro for future adoptive immunotherapy of cervical cancer. METHODS: Peripheral blood mononuclear cells (PBMC) were isolated from HLA-A2+ healthy donors. The PBMCs were incubated with HPV-16 E7(11-20) peptide and varying cytokines in the primary culture. Restimulation was performed weekly with peptide-pulsed, irradiated autologous PBMCs. Alternatively, the PBMCs were depleted of abundant CD4+ cells and stimulated with HPV-16 E7(11-20) peptide-pulsed dendritic cells...
September 1999: Gynecologic Oncology
M Peters, J L Ambrus, A Zheleznyak, D Walling, J H Hoofnagle
We have investigated the effect of human recombinant interferon-alpha (IFN-alpha) on mitogen-induced immunoglobulin (Ig) production by peripheral blood mononuclear cells from normal individuals. Low concentrations (1 to 100 IU/ml) of IFN-alpha enhanced pokeweed mitogen-stimulated Ig production. In contrast, high concentrations of IFN-alpha (10(5) IU/ml) suppressed pokeweed mitogen-induced Ig production. Irradiation of T cells did not ablate the high dose suppression, indicating that suppression was not due to a radiation-sensitive T cell...
November 15, 1986: Journal of Immunology: Official Journal of the American Association of Immunologists
F Herrmann, J D Griffin, S G Meuer, K H Meyer zum Büschenfelde
Circulating mononuclear cells from a patient developing severe aplastic anemia during the course of non-A, non-B hepatitis were found to be virtually entirely composed of in vivo activated suppressor T cells (Ia+T8+). These cells were used to establish a new permanent cell line, termed SMAA, by using phytohemagglutinin, Ebstein-Barr virus-transformed irradiated B cells, allogeneic irradiated peripheral blood mononuclear cells, and recombinant interleukin 2 to investigate the relationship of aplastic anemia-derived circulating T cells to bone marrow failure...
March 1, 1986: Journal of Immunology: Official Journal of the American Association of Immunologists
R Yamamoto, T Shiba, K Tobe, Y Shibasaki, O Koshio, T Izumi, M Odawara, Y Mikami, N Matsuura, Y Akanuma
We report here a defect in tyrosine kinase activity of the insulin receptor from an insulin-resistant patient with acanthosis nigricans using cultured Ebstein-Barr virus (EBV)-transformed B-lymphocytes. As judged by affinity labeling and immunoblotting, the alpha- and beta-subunits of insulin receptors from the patient's lymphocytes exhibited the same mol wt as those from control subjects. Lectin-purified extracts from lymphocytes of the patient and the control subjects containing the same insulin-binding capacity were assayed for autophosphorylation and the ability to phosphorylate histone H2B...
April 1990: Journal of Clinical Endocrinology and Metabolism
T F Kresina, L W Cheever, M Chireau, J Johnson, B Ramirez, P Peters, G R Olds
Lymphocytes derived from the peripheral blood of individuals infected with Schistosoma japonica were transformed in vitro with Ebstein-Barr virus (EBV). Serological characterization of antibody molecules revealed both antigen reactive (idiotypic) and anti-idiotypic transformants. One idiotypic EBV transformant, LO2C2, describes a major cross-reactive idiotype associated with anti-antigen binding molecules. Other antibody populations expressing idiotypic cross-reactivity were derived from separate individuals showing shared idiotypy in S...
December 1992: Clinical Immunology and Immunopathology
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