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Creatinine clearance measurement

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https://www.readbyqxmd.com/read/29150412/clinical-benefits-of-using-inulin-clearance-and-cystatin-c-for-determining-glomerular-filtration-rate-in-hiv-1-infected-individuals-treated-with-dolutegravir
#1
Satomi Yukawa, Dai Watanabe, Tomoko Uehira, Takuma Shirasaka
INTRODUCTION: Dolutegravir may inhibit creatinine transporters in renal tubules and elevate serum creatinine levels. We investigated the usefulness of glomerular filtration rate (GFR) measured using inulin clearance (Cin), creatinine clearance (Ccr), and estimated GFR based on both serum creatinine (eGFRcre) and serum cystatin C (eGFRcys). PATIENTS & METHODS: HIV-1-infected Japanese patients with suppressed viremia and whose antiretroviral drug was switched to dolutegravir from other drugs were included (n = 108, Study 1)...
November 14, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29146282/-measurement-and-estimation-of-glomerular-filtration-rate
#2
Emmanuelle Vidal-Petiot, Martin Flamant
Glomerular filtration rate is the best quantitative marker of renal function. It allows diagnosis and classification of severe chronic kidney disease into five stages. Theoretically, the measurement of glomerular filtration rate is based on the calculation of urinary clearance of exogenous substances such as chromium 51-labeled inulin or ethylenediaminetetraacetic acid ([(51)Cr]-EDTA). In practice, glomerular filtration rate is most often estimated from equations derived from plasma creatinine. This article reviews the range of methods used to measure or approximate glomerular filtration rate and attempts to describe recent developments in this area, including those related to plasma creatinine assay methods, creatinine and cystatin C concentration-derived estimations...
November 13, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29139146/effects-of-the-sodium-glucose-cotransporter-2-sglt2-inhibitor-velagliflozin-a-new-drug-with-therapeutic-potential-to-treat-diabetes-in-cats
#3
M Hoenig, M Clark, D J Schaeffer, D Reiche
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are used in the treatment of human diabetics. They increase glucose excretion and correct hyperglycemia. We examined the investigational SGLT2 inhibitor velagliflozin in two groups of six neutered adult obese cats (equal gender distribution). Placebo (Pl) or drug (D; 1 mg/kg) was administered for 35 days. Routine blood examinations, fructosamine, beta-hydroxybutyrate (BHB), nonesterified fatty acids (NEFA), glucagon, adiponectin, and leptin were measured before and after treatment, also water intake, and urinary electrolytes, glucose, and volume...
November 15, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29120960/external-validation-and-comparison-of-formulae-estimating-24-h-sodium-intake-from-a-fasting-morning-urine-sample
#4
Emmanuelle Vidal-Petiot, Adrien Joseph, Matthieu Resche-Rigon, Anne Boutten, Jimmy Mullaert, Marie-Pia d' Ortho, François Vrtovsnik, Ph Gabriel Steg, Martin Flamant
OBJECTIVE: The relationship between sodium intake and cardiovascular events is controversial, but most large epidemiological studies estimated sodium intake using formulae based on single urine samples, the validity of which is debated. We evaluated sodium intake estimating formulae in a large cohort of adult patients. DESIGN AND METHODS: Patients were asked to collect 24-h urine the day before admission. Validity of the 24-h urine collection was assessed by comparing creatinine clearance from this collection to the mean creatinine clearance from six fractionated urine samples...
November 7, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29118772/one-year-conservative-care-using-sodium-bicarbonate-supplementation-is-associated-with-a-decrease-in-electronegative-ldl-in-chronic-kidney-disease-patients-a-pilot-study
#5
Felipe Rizzetto, Denise Mafra, Ana Beatriz Barra, Gisella Pires de Melo, Dulcinéia Saes Parra Abdalla, Maurilo Leite
Background: Chronic kidney disease (CKD) patients develop metabolic acidosis when approaching stages 3 and 4, a period in which accelerated atherogenesis may ensue. Studies in vitro show that low pH may increase low-density lipoprotein (LDL) oxidation, suggesting a role for chronic metabolic acidosis in atherosclerosis. The present study attempted to evaluate the effects of conservative care using oral sodium bicarbonate (NaHCO3) supplementation on the electronegative LDL [LDL(-)], a minimally oxidized LDL, plasma levels in CKD patients...
October 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29114005/residual-kidney-function-and-peritoneal-dialysis-associated-peritonitis-treatment-outcomes
#6
Rachel Whitty, Joanne M Bargman, Alex Kiss, Linda Dresser, Philip Lui
BACKGROUND AND OBJECTIVES: Residual kidney function contributes to the clearance of antibiotics excreted by the kidneys, lowering the antibiotic concentration, which may adversely affect the treatment of peritoneal dialysis-associated peritonitis. The objective of our study was to examine the relationship between residual kidneyfunction and peritonitis treatment outcomes. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Our study included 181 participants who experienced 339 episodes of Gram-positive, Gram-negative, and culture-negative peritoneal dialysis-associated peritonitis at a single centerfrom 2003 to 2010...
November 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29112711/pharmacokinetics-and-pharmacodynamic-target-attainment-of-benzylpenicillin-in-an-adult-severely-ill-sub-saharan-african-patient-population
#7
Jeannet C Bos, Reinier M van Hest, Mabor C Mistício, Ginto Nunguiane, Cláudia N Lang, José C Beirão, Ron A A Mathôt, Jan M Prins
Background: In intensive care (ICU) patients, systemic exposure of β-lactam antibiotics can be altered, and positive clinical outcome is associated with increasing fT>MIC ratios. In sub-Saharan African (SSA) hospitals, benzylpenicillin (PEN) is frequently used for the empirical treatment of severe pneumococcal infections. Pharmacokinetic data for non-ICU hospitalized populations are lacking. Methods: We performed a population pharmacokinetic (PPK) study in an adult Mozambican hospital population treated intravenously with PEN from October 2014-November 2015...
November 3, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29096403/impact-of-lean-mass-and-bone-density-on-glomerular-filtration-rate-estimation-in-people-living-with-hiv-aids
#8
Corinne Isnard Bagnis, Laurence Pieroni, Rachida Inaoui, Philippe Maksud, Stéphanie Lallauret, Marc-Antoine Valantin, Roland Tubiana, Christine Katlama, Gilbert Deray, Marie Courbebaisse, Jérôme Tourret, Sophie Tezenas du Montcel
CONTEXT: Chronic kidney disease is a frequent complication in persons living with HIV/AIDS. Although previous studies have suggested that the CKD-EPI formula is appropriate to estimate glomerular filtration rate (GFR) in HIV-positive adults with normal kidney function, the optimal way to estimate GFR in those with Stage 3 chronic kidney disease is not known. Moreover, the impact of muscle mass on creatinine level and GFR estimation is unknown. AIM AND METHODS: Our study aimed to evaluate the accuracy of different diagnostic tests available compared to the gold standard measurement of GFR...
2017: PloS One
https://www.readbyqxmd.com/read/29089475/melatonin-and-or-rowatinex-attenuate-streptozotocin-induced-diabetic-renal-injury-in-rats
#9
Tarek K Motawi, Samia A Ahmed, Manal A Hamed, Shohda A El-Maraghy, Wessam M Aziz
The study aimed to explore the prophylactic effect of melatonin, rowatinex; a naturally occurring renal drug, and its combination on diabetic nephropathy in type 2 diabetic rats. Diabetes was induced by intraperitoneal injection of a single dose of streptozotocin (50 mg/g body weight). Three days before diabetes induction, rats were daily treated with melatonin, rowatinex and their combination continuously for 8 weeks. Evaluation was done through measuring blood urea nitrogen (BUN), serum uric acid, serum creatinine, urine creatinine, creatinine clearance, nitric oxide (NO), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), total antioxidant capacity (TAC), kidney injury molecule-1 (KIM-1), heat shock protein-70 (HSP-70), caspase-3, transforming growth factor β1 (TGFβ1), DNA degradation by the comet assay and total protein contents...
November 1, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29080620/comparison-of-hypotensive-diuretic-and-renal-effects-between-cladodes-of-opuntia-ficus-indica-and-furosemide
#10
Meryem Bakour, Noori Al-Waili, Redouan El-Haskoury, Nawal El-Menyiy, Thia Al-Waili, Ali Al-Waili, Badiaa Lyoussi
OBJECTIVE: To investigate the diuretic, hypotensive and renal effect of Opuntia ficus-indica in two different species in oral and intravenous administration. METHODS: Diuretic activity was evaluated in rats with the plant cladode gel and aqueous extract administrated orally, and was evaluated in rabbits with plant extract administered intravenously. Single and repeated doses of cladode gel or aqueous extract of cladode were tested. Urine volume and blood and urine creatinine, sodium and potassium were measured, and creatinine clearance was calculated...
September 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29079637/consensus-guideline-for-use-of-glucarpidase-in-patients-with-high-dose-methotrexate-induced-acute-kidney-injury-and-delayed-methotrexate-clearance
#11
Laura B Ramsey, Frank M Balis, Maureen M O'Brien, Kjeld Schmiegelow, Jennifer L Pauley, Archie Bleyer, Brigitte C Widemann, David Askenazi, Sharon Bergeron, Anushree Shirali, Stefan Schwartz, Alexander A Vinks, Jesper Heldrup
Acute kidney injury due to high-dose methotrexate (HDMTX) is a serious, life-threatening toxicity that can occur in pediatric and adult patients. Glucarpidase is a treatment approved by the Food and Drug Administration for high methotrexate concentrations in the context of kidney dysfunction, but the guidelines for when to use it are unclear. An expert panel was convened to provide specific, expert consensus guidelines for the use of glucarpidase in patients who develop HDMTX-induced nephrotoxicity and delayed methotrexate excretion...
October 27, 2017: Oncologist
https://www.readbyqxmd.com/read/29079274/glomerular-filtration-rate-is-associated-with-free-triiodothyronine-in-euthyroid-subjects-comparison-between-various-equations-to-estimate-renal-function-and-creatinine-clearance
#12
Josephine L C Anderson, Eke G Gruppen, Lynnda van Tienhoven-Wind, Michele F Eisenga, Hanne de Vries, Ron T Gansevoort, Stephan J L Bakker, Robin P F Dullaart
BACKGROUND: Effects of variations in thyroid function within the euthyroid range on renal function are unclear. Cystatin C-based equations to estimate glomerular filtration rate (GFR) are currently advocated for mortality and renal risk prediction. However, the applicability of cystatin C-based equations is discouraged in patients with overt thyroid dysfunction, since serum cystatin C and creatinine levels are oppositely affected by thyroid dysfunction. Here, we compared relationships of thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) with various measures of kidney function in euthyroid subjects...
October 24, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29077618/urinary-oxygenation-as-a-surrogate-measure-of-medullary-oxygenation-during-angiotensin-ii-therapy-in-septic-acute-kidney-injury
#13
Yugeesh R Lankadeva, Junko Kosaka, Roger G Evans, Rinaldo Bellomo, Clive N May
OBJECTIVES: Angiotensin II is an emerging therapy for septic acute kidney injury, but it is unknown if its vasoconstrictor action induces renal hypoxia. We therefore examined the effects of angiotensin II on intrarenal PO2 in ovine sepsis. We also assessed the validity of urinary PO2 as a surrogate measure of medullary PO2. DESIGN: Interventional study. SETTING: Research Institute. SUBJECTS: Sixteen adult Merino ewes (n = 8/group)...
October 26, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29075676/direct-acting-antivirals-in-kidney-transplant-patients-successful-hepatitis-c-treatment-and-short-term-reduction-in-urinary-protein-creatinine-ratios
#14
Michael R Goetsch, Ashutosh Tamhane, Mohit Varshney, Anuj Kapil, Edgar T Overton, Graham C Towns, Ricardo A Franco
BACKGROUND: The role of Hepatitis C Virus (HCV) clearance in kidney graft survival is unknown. We examined short-term trends of protein/creatinine (P/C) ratios in HCV-infected kidney transplant recipients treated with direct-acting antivirals (DAAs). METHODS: This is a retrospective study of 19 kidney transplant patients with HCV infection treated with DAAs at the University of Alabama at Birmingham between January 2013 and June 2016. Markers of glomerular damage were assessed using average urinary protein/creatinine (P/C) ratios measured pretreatment and posttreatment...
2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/29070045/haemoadsorption-reduces-the-inflammatory-response-and-improves-blood-flow-during-ex-vivo-renal-perfusion-in-an-experimental-model
#15
Sarah A Hosgood, Tom Moore, Theresa Kleverlaan, Tom Adams, Michael L Nicholson
BACKGROUND: Ex-vivo normothermic perfusion strategies are a promising new instrument in organ transplantation. The perfusion conditions are designed to be protective however the artificial environment can induce a local inflammatory response. The aim of this study was to determine the effect of incorporating a Cytosorb adsorber into an isolated kidney perfusion system. METHODS: Porcine kidneys were subjected to 22 h of cold ischaemia then reperfused for 6 h on an ex vivo reperfusion circuit...
October 25, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29064737/effects-of-apoe-haplotypes-and-measures-of-cardiovascular-risk-over-gender-dependent-cognitive-and-functional-changes-in-one-year-in-alzheimer-s-disease
#16
Fabricio Ferreira de Oliveira, Fernando Vieira Pereira, Glaucia Akiko Kamikado Pivi, Marilia Cardoso Smith, Paulo Henrique Ferreira Bertolucci
BACKGROUND: Illiteracy, high cerebrovascular risk and copies of APOE-ϵ4 are risk factors for Alzheimer's disease dementia (AD). We aimed to investigate the impacts of gender, education, coronary heart disease (CHD) risk and creatinine clearance variations, body mass index (BMI) and APOE haplotypes over the rates of cognitive and functional decline of AD in one year. METHODS: Consecutive outpatients with late-onset AD were assessed for gender, schooling, BMI and APOE haplotypes, variations in one year of creatinine clearance and Framingham projections of the 10-year absolute CHD risk, and prospective scores of the Mini-Mental State Examination (MMSE), the Clinical Dementia Rating Sum-of-Boxes (CDR-SOB), the Index of Independence in Activities of Daily Living (ADL) and Lawton's Scale for Instrumental Activities of Daily Living (IADL)...
October 24, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29064177/microrna-499-gene-expression-in-patients-on-hemodialysis-with-cardiovascular-complications
#17
Magdi El Sharkawy, Amr Mohab, Haitham Ezzat
BACKGROUND: MicroRNA (miRNA) 499 is an evolutionarily conserved muscle-specific miRNA that is encoded by an intron of the myh7 gene and is likely to play a role in myosin gene regulation. It has been shown to be involved in inhibiting apoptosis and myocardial infarction induced by ischemia and anoxia. It is unknown whether levels of miRNAs are affected in patients undergoing hemodialysis. OBJECTIVE: The aim of this study was to assess circulating levels of miRNA 499 in hemodialysis patients and whether the levels are affected by dialyzer membranes (high flux vs...
October 2017: Hemodialysis International
https://www.readbyqxmd.com/read/29064175/verification-of-physicochemical-structures-of-dialysis-membrane-using-reversal-dialysis-technique
#18
Akihiro C Yamashita, Takahisa Ono, Narumi Tomisawa
OBJECTIVE: Solute removal performance of the dialyzer is closely related to physicochemical structures of the membrane. The objective of this study is to devise a new in vitro evaluation technique to directly correlate the physicochemical structures of the membrane to the dialysis performance. MATERIALS AND METHODS: Commercial 11 dialyzers with cellulose triacetate (CTA), ethylene vinylalcohol co-polymer (EVAL), asymmetry CTA (termed ATA), 4 polysulfone (PSf), polyether sulfone (PES), and 3 polyester polymer alloy (PEPA) membranes were employed for investigation...
October 2017: Hemodialysis International
https://www.readbyqxmd.com/read/29062906/elevated-cystatin-c-is-it-a-reflection-for-kidney-or-liver-impairment-in-hepatic-children
#19
Behairy El-Sayed, Hanaa El-Araby, Nermin Adawy, Mona Hassona, Naglaa El-Nady, Haidy Zakaria, Mohammed Khedr
AIM OF THE STUDY: To assess if elevated serum cystatin C (Cyst-C) is an indicator for renal or hepatic dysfunction in presence of liver fibrosis. MATERIAL AND METHODS: Data of 50 children with chronic liver diseases (CLDs), out of which 25 were without renal impairment, and 25 with renal impairment were analyzed. Twenty healthy children served as a healthy control group. Routine investigations, creatinine clearance, hepatitis viral markers, abdominal ultrasonography, and liver biopsy were performed for patients with CLDs...
September 2017: Clin Exp Hepatol
https://www.readbyqxmd.com/read/29057582/an-exploratory-pilot-study-with-copeptin-as-a-biomarker-for-individualizing-treatment-for-nocturnal-polyuria
#20
Elke Bruneel, An-Sofie Goessaert, Marie-Astrid Denys, Kristian V Juul, Jens P Nørgaard, Karel Everaert
OBJECTIVE: The aim of the present study was to investigate the use of random copeptin concentrations as possible biomarkers for the differential diagnosis of nocturnal polyuria (NP). METHODS: In all, 111 patients with and without nocturia were enrolled in the study. Patients with a neurogenic bladder and/or those who had undergone bladder or urethral surgery were excluded from the study. All patients completed a 72-hour frequency-volume chart and a renal function profile...
October 23, 2017: Lower Urinary Tract Symptoms
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