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Tendon injuries

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https://www.readbyqxmd.com/read/29667905/essential-role-of-mohawk-for-tenogenic-tissue-homeostasis-including-spinal-disc-and-periodontal-ligament
#1
Ryo Nakamichi, Kensuke Kataoka, Hiroshi Asahara
Tendons and ligaments play essential roles in connecting muscle and bone and stabilizing the connections between bones. The damage to tendons and ligaments caused by aging, injury, and arthritis induces the dysfunction of the musculoskeletal system and reduces the quality of life. Current therapy for damaged tendons and ligaments depends on self-repair; however, it is difficult to reconstruct normal tissue. Regeneration therapy for tendons and ligaments has not been achieved, partly because the mechanism, cell biology, and pathophysiology of tendon and ligament development remain unclear...
April 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29665604/-foreign-material-free-anterior-cruciate-ligament-repair-with-hamstring-graft-felmet-technique
#2
Marc Chmielnicki, Wolfram Siebert, Axel Prokop
Rupture of the anterior cruciate ligament (ACL) is a common sports injury. Shear forces can damage the articular cartilage and lead to early osteoarthritis. Ligamentary stabilisation of the knee is necessary. Today, arthroscopic ACL repair is a standard knee procedure. Transplant fixation is often performed using implants, e.g. interference screws. The foreign material-free procedure using the Felmet technique enables biological, mechanically stable fixation of the hamstring tendon graft. We demonstrate the surgical technique, including meniscus suture and a video case study...
April 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29664017/specialized-fibroblast-differentiated-states-underlie-scar-formation-in-the-infarcted-mouse-heart
#3
Xing Fu, Hadi Khalil, Onur Kanisicak, Justin G Boyer, Ronald J Vagnozzi, Bryan D Maliken, Michelle A Sargent, Vikram Prasad, Iñigo Valiente-Alandi, Burns C Blaxall, Jeffery D Molkentin
Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate acute wound healing and long-term tissue remodeling with scarring. With myocardial infarction injury, cardiomyocytes are replaced by secreted extracellular matrix proteins produced by proliferating and differentiating fibroblasts. Here, we employed 3 different mouse lineage-tracing models and stage-specific gene profiling to phenotypically analyze and classify resident cardiac fibroblast dynamics during myocardial infarction injury and stable scar formation...
April 16, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29664015/a-new-concept-of-fibroblast-dynamics-in-post-myocardial-infarction-remodeling
#4
Thomas Eschenhagen
The identity and function of the fibroblast, a highly prevalent cell type in the heart, have remained poorly defined. Recent faithful genetic lineage-tracing studies revealed that during development, the cardiac fibroblasts are derived from the epicardium and the endothelium, whereas in the adult heart, they constitute the cardiac injury-responsive resident fibroblast. In the current issue of the JCI, Molkentin and colleagues decipher the time course and mechanism of the fibroblast in response to myocardial infarction (MI)...
April 16, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29663091/anatomical-feasibility-study-of-flexor-hallucis-longus-transfer-in-treatment-of-achilles-tendon-and-posteromedial-portal-of-ankle-arthroscopy
#5
Haijiao Mao, Linger Wang, Wenwei Dong, Zhenxin Liu, Weigang Yin, Dachuan Xu, Keith L Wapner
PURPOSE: The aim of this study was to evaluate the occurrence of anatomical variations of the musculotendinous junction of the flexor hallucis longus (FHL) muscle, the relationship between FHL tendon or muscle and the tibial neurovascular bundle at the level of the posterior ankle joint in human cadavers. METHODS: Seventy embalmed feet from 20 male and 15 female cadavers, the cadavers' mean age was 65.4 (range from 14 to 82) years, were dissected and anatomically classified to observe FHL muscle morphology define the relationship between FHL tendon or muscle and the tibial neurovascular bundle...
April 16, 2018: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29663013/bone-to-bone-integrations-were-complete-within-5-months-after-anatomical-rectangular-tunnel-anterior-cruciate-ligament-reconstruction-using-a-bone-patellar-tendon-bone-graft
#6
Hironari Masuda, Shuji Taketomi, Hiroshi Inui, Naoya Shimazaki, Nobuhiro Nishihara, Seikai Toyooka, Hirotaka Kawano, Takumi Nakagawa
PURPOSE: Anterior cruciate ligament (ACL) reconstruction using a bone-patellar tendon-bone (BTB) graft is known to provide secure fixation due to the direct bone-to-bone integration of the bone plug and bone tunnel. It is important to know the time required for bone integration when designing the postoperative rehabilitation protocol or deciding when the patient can return to competition-level activity, especially if the patient is an athlete. However, because reports are scarce, the period necessary for bone-to-bone integration after ACL reconstruction using a BTB graft remains unclear...
April 16, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29662910/outcomes-and-return-to-sport-after-revision-anterior-cruciate-ligament-reconstruction-in-adolescent-athletes
#7
Michael Saper, Stephanie Pearce, Joseph Shung, Robert Zondervan, Roger Ostrander, James R Andrews
Background: The number of adolescent anterior cruciate ligament (ACL) injuries is rising with increased participation in higher level athletics at earlier ages. With an increasing number of primary ACL reconstructions (ACLRs) comes a rise in the incidence of revision ACLRs. Purpose: To evaluate the clinical results of revision ACLR across a group of high-level adolescent athletes with at least 2-year follow-up. Study Design: Case series; Level of evidence, 4...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29662762/local-administration-of-trolox-a-vitamin-e-analog-reduced-tendon-adhesion-in-a-chicken-model-of-flexor-digitorum-profundus-tendon-injury
#8
Yuk Wa Lee, Sai Chuen Fu, Tsui Yu Mok, Kai Ming Chan, Leung Kim Hung
Background: Hand flexor tendon injuries are compromised with tendon adhesion. Tendon adhesion forms between flexor tendon and tendon sheath, reduces the range of motion of fingers, and affects their function. Oxidative stress is increased in flexor tendon after injury and might play a role in tendon adhesion formation. Trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid), a water-soluble analog of vitamin E, is antioxidative. Trolox reduced oxidative stress and the expression of fibrotic cytokines in the bile gut ligation animal model...
July 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29658926/evaluation-of-stem-cell-therapies-in-a-bilateral-patellar-tendon-injury-model-in-rats
#9
John R Wagner, Takashi Taguchi, Jane Y Cho, Chandrashekhar Charavaryamath, Dominique J Griffon
Regenerative medicine provides novel alternatives to conditions that challenge traditional treatments. The prevalence and morbidity of tendinopathy across species, combined with the limited healing properties of this tissue, have prompted the search for cellular therapies and propelled the development of experimental models to study their efficacy. Umbilical cord matrix-derived mesenchymal stem cells (UCM-MSC) are appealing candidates because they are abundant, easy to collect, circumvent the ethical concerns and risk of teratoma formation, yet resemble primitive embryonic stem cells more closely than adult tissue-derived MSCs...
March 30, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29658519/biomechanical-evaluation-of-tendon-connection-with-novel-suture-techniques
#10
Zhe Chen, Jun Wang, Jia-Sen Wei, Zhao-Yang Hou, Min Li, Qi-Xin Chen
PURPOSE: Achilles tendon rupture is a severe injury with poor curative effect due to its anatomical characteristic and mechanical peculiarity. Internal fixation of limited loop (IFLL) with steel-wire has been applied on patients with tendon rupture to fix the broken ends before physical rehabilitation. The purpose of this study is to investigate the biomechanical property and radiological characteristic of such suture technique for the repairment of tendon rupture. METHODS: Tendons of pigs' hint feet were separated for the biomechanical study...
2018: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29658150/proximal-patellar-tendon-pathology-can-develop-during-adolescence-in-young-ballet-dancers-a-2-year-longitudinal-study
#11
A Rudavsky, J L Cook, S Docking
PURPOSE: Patellar tendinopathy (tendon pain and dysfunction), or jumper's knee is prevalent in adult jumping athletes. Pathology in the proximal patellar tendon is a key risk factor for developing patellar tendinopathy. When pathology develops in the proximal patellar tendon is not known, though it is reported to exist in adolescent athletes. The aim of this study was to follow young jumping athletes (ballet dancers) through adolescence to identify if pathology develops and its relation to the adolescent growth spurt...
April 15, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29657849/talar-process-fractures-an-overview-and-update-of-the-literature
#12
Haroon Majeed, Donald J McBride
Fractures of the lateral and the posterior processes of the talus are uncommon and frequently missed because of a low level of suspicion and difficulty in interpretation on plain radiographs. Missed fractures can lead to persistent pain and reduced function.Lateral process fractures are usually a consequence of forced dorsiflexion and inversion of fixed pronated foot. These are also commonly known as snowboarder's fractures.The posterior process of the talus is composed of medial and lateral tubercles, separated by the groove for the flexor hallucis longus tendon...
March 2018: EFORT Open Reviews
https://www.readbyqxmd.com/read/29657436/upper-extremity-weightlifting-injuries-diagnosis-and-management
#13
REVIEW
Kayvon Golshani, Mark E Cinque, Peter O'Halloran, Kenneth Softness, Laura Keeling, J Ryan Macdonell
Common upper extremity injuries in resistance training athletes include muscle strains, ligament sprains, pectoralis major tendon ruptures, distal biceps tendon ruptures, and chronic shoulder pain and capsulolabral injuries. While each injury is unique in its specific anatomic location and mechanism, each is preventable with proper exercise technique, safety and maintenance of muscle balance. Conservative treatment is the therapeutic modality of choice and these injuries generally resolve with workout modification, appropriate recovery, anti-inflammatory medication, and physical therapy...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29655650/surgical-treatment-of-lisfranc-injury-with-plantar-plate-approach
#14
Deepal Dalal, Christian Curry, Ryan Carter, Colin Zdenek, Nicholas W Todd, Shannon M Rush, Richard Jensen
Midfoot injuries are the second most common athletic foot injury documented in the published data. High-energy Lisfranc dislocations are commonly seen secondary to traumatic etiologies and disrupt the strong midfoot ligaments supporting the arch. These injuries require immediate surgical intervention to prevent serious complications such as compartment syndrome and amputation. The present case series reports a new Lapidus plate system used in 3 patients who underwent arthrodesis procedures for Lisfranc joint dislocation...
April 11, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29650376/trapezius-muscle-transfer-for-restoration-of-elbow-extension-in-a-traumatic-brachial-plexus-injury
#15
Hamza M Alrabai, Martin G Gesheff, Ahmed I Hammouda, Janet D Conway
Voluntary elbow extension is essential for optimal upper limb positioning required for daily living activities, particularly above-shoulder maneuvers. The authors present a case of traumatic brachial plexus injury in which paralysis of the musculature selectively supplied by the posterior cord was based on magnetic resonance imaging and nerve conduction studies. An attempt at a radial nerve graft at another center was not effective. Ipsilateral hand function improved after multiple local tendon transfers were performed...
April 9, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29650048/a-comparison-of-the-stem-cell-characteristics-of-murine-tenocytes-and-tendon-derived-stem-cells
#16
Katie Joanna Lee, Peter David Clegg, Eithne Josephine Comerford, Elizabeth Gail Canty-Laird
Tendon is a commonly injured soft musculoskeletal tissue, however, poor healing potential and ineffective treatment strategies result in persistent injuries and tissue that is unable to perform its normal physiological function. The identification of a stem cell population within tendon tissue holds therapeutic potential for treatment of tendon injuries. This study aimed, for the first time, to characterise and compare tenocyte and tendon-derived stem cell (TDSC) populations in murine tendon. Tenocytes and TDSCs were isolated from murine tail tendon...
April 12, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29643421/serpine1-knockdown-enhances-mmp-activity-after-flexor-tendon-injury-in-mice-implications-for-adhesions-therapy
#17
Margaret A T Freeberg, Youssef M Farhat, Anas Easa, Jacob G Kallenbach, Dominic W Malcolm, Mark R Buckley, Danielle S W Benoit, Hani A Awad
Injuries to flexor tendons can be complicated by fibrotic adhesions, which severely impair the function of the hand. Adhesions have been associated with TGF-β1, which causes upregulation of PAI-1, a master suppressor of protease activity, including matrix metalloproteinases (MMP). In the present study, the effects of inhibiting PAI-1 in murine zone II flexor tendon injury were evaluated utilizing knockout (KO) mice and local nanoparticle-mediated siRNA delivery. In the PAI-1 KO murine model, reduced adherence of injured tendon to surrounding subcutaneous tissue and accelerated recovery of normal biomechanical properties compared to wild type controls were observed...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29642947/absence-of-flexor-carpi-radialis-identified-during-volar-approach-for-fixation-of-distal-radius-fracture-a-case-report
#18
Tomoyo Irie, Makoto Motomiya, Norimasa Iwasaki
BACKGROUND: Volar locking plate fixation of distal radius fractures is commonly performed because of its good clinical outcomes. The flexor carpi radialis (FCR) approach is one of the most popular approaches to dissecting the volar side of the distal radius because of its simplicity and safety. We describe an extremely rare case of an absent FCR identified during a volar approach for fixation of a distal radius fracture. CASE PRESENTATION: A 59-year-old woman with distal radius fracture underwent surgery using the usual FCR approach and volar locking plate...
April 11, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29627350/bedside-ultrasound-diagnosis-of-complete-achilles-tendon-tear-in-a-25-year-old-man-with-calf-injury
#19
Mitchell Odom, Nathan Haas, Kylee Phillips
No abstract text is available yet for this article.
April 4, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29627114/partial-medial-second-toe-pulp-free-flap-and-dermal-substitute-with-skin-graft-for-salvage-reconstruction-of-a-complete-skin-envelope-degloving-of-the-small-finger
#20
V Calafat, C Strugarek, D Montoya-Faivre, F Dap, G Dautel
Skin envelope degloving of fingers are rare injuries that require rapid care and surgical treatment. Mostly caused by ring finger injuries, these traumas include bone, tendon and neurovascular pedicle damage. The authors present an unusual case of finger degloving limited exclusively to the skin envelope, without skeletal, tendinous or vascular lesion. This rare case of skin envelope degloving rendered microsurgical revascularization impossible. The authors report the results at 12 months following salvage reconstruction combining a partial second toe pulp free flap for the volar side and a dermal substitute with a thin skin graft for the dorsum...
April 4, 2018: Annales de Chirurgie Plastique et Esthétique
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