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Lichen planus

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https://www.readbyqxmd.com/read/28092258/-frontal-fibrosing-alopecia-case-series-and-literature-review
#1
Fátima Tinoco-Fragoso, Judith Domínguez-Cherit, Silvia Méndez-Flores
Frontal fibrosing alopecia is a disease characterized by a symmetric and progressive loss of hair in the fronto-temporal and fronto-parietal lines that generally affects postmenopausal women. It is considered a variant of lichen planus pilaris for its clinical and histopathological features; although, its etiopathology is still unknown. In this report, we analyzed 4 cases of this disease and we discussed its clinical and histopathological characteristics, as well as their course after initiating treatment.
January 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28079787/oral-and-vulvo-vaginal-lichenoid-reactions-due-to-mitotane-lysodren-a-case-report
#2
Arthur Schmouchkovitch, Héloïse Herry, Philippe Thuillier, Véronique Kerlan, Camille Fleuret, Guy Le Toux, Sylvie Boisramé
BACKGROUND: The purpose of pharmacovigilance (drug safety) is collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products. It is meant to identify, characterize, prevent, or minimize actual or potential risks relating to medicinal products. To prevent these adverse effects and improve our practice, health professionals have a duty to report side effects to assess this risk and evaluate the benefit/risk requirements. Mitotane (Lysodren) is used for treating adrenocortical carcinoma...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28077900/prevalence-of-oral-lichen-planus-in-diabetes-mellitus-a-meta-analysis-study
#3
Hamid Reza Mozaffari, Roohollah Sharifi, Masoud Sadeghi
BACKGROUND: Oral lichen planus (OLP) is associated with various other systemic conditions such as hypertension, diabetes mellitus (DM). This study evaluated the prevalence of OLP in DM patients compared with non-diabetic control subjects in a meta-analysis study. METHODS: In this study from January 1973 to August 2016, we searched the studies in Web of Science, Medline/PubMed, Scopus, Science direct, SID (Scientific Information Database), Cochrane and Embase databases...
December 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28076570/bilateral-retinal-vasculitis-in-a-patient-with-lichen-planus
#4
Seyhan Dikci, Oğuzhan Genç, Turgut Yılmaz, Penpe Gül Fırat
Lichen planus (LP) is an autoimmune, inflammatory disease of unknown etiology that commonly affects the skin and mucous membranes. Retinal vasculitis is a group of vision-threatening disorders, in which autoimmunity is thought to play a role in pathogenesis. We present the case of a patient who was diagnosed with retinal vasculitis and who was followed up for mucosal LP. LP has not been reported as a cause of retinal vasculitis in the literature. We believe that the retinal vasculitis in this case was related to LP because cellular immunity plays a role in the pathogenesis of both entities...
November 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28076499/association-between-the-clinical-severity-of-oral-lichen-planus-and-anti-tpo-level-in-thyroid-patients
#5
Milad Alikhani, Parichehr Ghalaiani, Elham Askariyan, Zahra Ahmadi Khunsaraki, Atefeh Tavangar, Aliasghar Naderi
This study considered a possible relationship between the severity of oral lichen planus (OLP), serum anti-TPO autoantibodies (TPOAb) titer and thyroid disease in OLP patients. Forty-six OLP patients with positive TPOAb results (> 35 IU/ml) who had also been diagnosed with thyroid disease were included in the study group. The control group consisted of 46OLP patients with no thyroid disease. The study and control groups (92) were divided to two subgroups of erosive OLP (EOLP) and non-erosive OLP (NEOLP)...
January 5, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28065765/genome-wide-association-study-identifies-risk-variants-for-lichen-planus-in-patients-with-hepatitis-c-virus-infection
#6
Yumiko Nagao, Nao Nishida, Licht Toyo-Oka, Atsushi Kawaguchi, Antonio Amoroso, Marco Carrozzo, Michio Sata, Masashi Mizokami, Katsushi Tokunaga, Yasuhito Tanaka
BACKGROUND & AIMS: There is a close relationship between hepatitis C virus (HCV) infection and lichen planus, a chronic inflammatory muco-cutaneous disease. We performed a genome-wide association study (GWAS) to identify genetic variants associated with HCV-related lichen planus. METHODS: We conducted a GWAS of 261 patients with HCV infection treated at a tertiary medical center in Japan from October 2007 through January 2013; 71 had lichen planus and 190 had normal oral mucosa...
January 5, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28061900/a-clitoral-verrucous-carcinoma-in-an-area-of-lichen-planus-has-aggressive-features
#7
Wiebren A A Tjalma, Vasiliki Siozopoulou, Manon T Huizing
BACKGROUND: Verrucous carcinoma of the vulva is extremely rare. It is a slow growing, low malignant variant of a squamous cell carcinoma with a cauliflower appearance. Women with lichen planus have an increased risk of developing vulval cancer. CASE PRESENTATION: A 79-year-old woman consulted for vulval itching. On clinical examination, a 3-cm large verrucous clitoral cancer in an area of lichen planus was seen. Based on her last clinical examination, the growth was estimated to be 1 cm(2) per month with an invasion depth after 6 months of 5 mm...
January 6, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28060366/oral-lichenoid-lesions-distinguishing-the-benign-from-the-deadly
#8
Susan Müller
Oral lichen planus is a chronic inflammatory disease of unknown etiology or pathogenesis with varied disease severity that waxes and wanes over a long period of time. Although a common oral mucosal disease, accurate diagnosis is often challenging due to the overlapping clinical and histopathological features of oral lichen planus and other mucosal diseases. Other immune-mediated mucocutaneous diseases can exhibit lichenoid features including mucous membrane pemphigoid, chronic graft-versus-host disease, and discoid lupus erythematosus...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28055124/interventions-for-the-management-of-oral-lichen-planus-a-review-of-the-conventional-and-novel-therapies
#9
REVIEW
Shikha Gupta, Sujoy Ghosh, Sunita Gupta
OBJECTIVE: This narrative review focuses on the rationale & role of conventional and newer therapies in the management of Oral lichen planus with emphasis on randomized controlled trials reported over 2 decades. MATERIALS AND METHODS: Literature search was conducted to identify randomized controlled trials for management of OLP from 1/1/1995 to 31/12/2015; Medline, and Cochrane databases complemented with manual search was used. Primary outcome as resolution of pain was evaluated with analysis of clinical resolution of erythema and ulceration as secondary outcome...
January 5, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28055072/diversity-in-dermatology-clinical-trials-a-systematic-review
#10
Alexandra Charrow, Fan Di Xia, Cara Joyce, Arash Mostaghimi
Importance: Though there have been significant shifts in US demographic data over the past 50 years, research cohorts lack full racial and ethnic representation. There is little data available regarding the diversity of dermatology research cohorts with respect to sex, race, and ethnicity. Objective: To characterize and assess the representation of racial and ethnic minorities and women in randomized controlled trials across a range of dermatologic conditions. Evidence Review: All randomized clinical trials (RCTs) were identified between July 2010 and July 2015 within the PubMed database using the following keywords: "psoriasis," "atopic dermatitis," "acne," "vitiligo," "seborrheic dermatitis," "alopecia areata," and "lichen planus...
January 4, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28050485/metabolic-derangements-in-lichen-planus-a-case-control-study
#11
Bikash Ranjan Kar, Maitreyee Panda, Nibedita Patro
INTRODUCTION: An association between psoriasis and metabolic syndrome has been established in previous studies. Lichen Planus (LP) is also a chronic inflammatory disease morphologically related to psoriasis and few studies have shown association of metabolic derangements in LP. AIM: To study the association of metabolic derangements in LP. MATERIALS AND METHODS: A prospective case control study was undertaken for a period of one year. Age and sex matched patients of LP and other non-inflammatory diseases were taken as cases and controls respectively...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28045749/histologic-assessment-of-lichenoid-dermatitis-observed-in-patients-with-advanced-malignancies-on-antiprogramed-cell-death-1-anti-pd-1-therapy-with-or-without-ipilimumab
#12
Shaun Chou, Shelley Ji Eun Hwang, Giuliana Carlos, Deepal Wakade, Pablo Fernandez-Penas
Lichenoid drug reaction is a common adverse reaction in patients taking immune-modulatory agents such as antiprogramed cell death (PD-1) and cytotoxic T lymphocyte antigen-4 agents. The authors describe the clinical and histologic features of lichenoid drug reaction in 20 biopsies from 15 patients on anti-PD-1 agents and 9 biopsies from 7 patients on anti-PD-1 plus ipilimumab therapy. Clinically, all except 2 patients presented with discrete, violaceous exanthematous papules to plaques. The lichenoid inflammation in the majority (18 of 29 biopsies) was florid although histology was quite heterogeneous...
January 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28042431/vulvovaginal-gingival-lichen-planus-report-of-two-cases-and-review-of-literature
#13
REVIEW
A Lucchese, A Dolci, G Minervini, C Salerno, D DI Stasio, G Minervini, L Laino, F Silvestre, R Serpico
PURPOSE: Oral Lichen Planus (OLP) is a chronic inflammatory disease of skin and mucous membranes. Approximately 20% of women with oral lichen planus develops lesions in the genital mucosa. In 1982, Pelisse described a special form of lichen planus (LP), which consists of a triad of symptoms: vulval, vaginal and gingival (VVG)-LP lesions. Aim of the present report is to report two new cases and review the international literature. MATERIAL AND METHODS: Two cases of VVG-LP are reported and a review of recent literature is performed...
April 2016: Oral & Implantology
https://www.readbyqxmd.com/read/28035216/treatment-modalities-of-palmoplantar-lichen-planus-a-brief-review
#14
REVIEW
Amir Feily, Reza Yaghoobi, Mohammad Ali Nilforoushzadeh
Palmoplantar lichen planus is a localized and uncommon variant of lichen planus which is mostly resistant to treatment. Our purpose was to discuss all treatment modalities proposed and tested for palmoplantar lichen planus in the literature. A systematic review of the literature was conducted to evaluate evidence regarding all treatment modalities proposed and tested for palmoplantar lichen planus in the literature. Two major databases (PubMed, Google scholar) were searched. The review included all case reports, letters and original articles reporting any treatment for palmoplantar lichen planus but not treatment used in the other type of lichen planus, generalized lichen planus or other type of palmoplantar dermatoses...
December 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28029732/the-efficacy-of-aloe-vera-in-management-of-oral-lichen-planus-a-systematic-review-and-meta-analysis
#15
REVIEW
Shereen Ali, Walaa Wahbi
OBJECTIVES: The main objective of oral lichen planus management is to control symptomatic outbreaks via eliminating lesions and alleviating symptoms. Corticosteroids; calcineurin inhibitors and most of the available modalities are associated with adverse effects which may limit their use. The aim of this review was to assess the effect of Aloe Vera on pain alleviation and/or clinical improvement in patients with symptomatic oral lichen planus. METHODS: MEDLINE-PubMed; CENTRAL and LILACS were searched in May, 2016 to identify all clinical trials evaluating Aloe Vera versus placebo or corticosteroids for treatment of oral lichen planus...
December 28, 2016: Oral Diseases
https://www.readbyqxmd.com/read/28028908/allelic-loss-in-amalgam-associated-oral-lichenoid-lesions-compared-to-oral-lichen-planus-and-mucosa
#16
Leonardo Nogueira Rodrigues, Sílvia Ferreira Sousa, Raissa Cristina Costa Silva, Mauro Henrique Guimarães Abreu, Fábio Ramôa Pires, Ricardo Alves Mesquita, Luciana Bastos-Rodrigues, Luiz De Marco, Carolina Cavaliéri Gomes, Ricardo Santiago Gomez, Vanessa Fátima Bernardes
BACKGROUND: The amalgam-associated oral lichenoid lesion (AAOLL) shows clinical and histopathological features similar to oral lichen planus (OLP). Molecular researches to improve knowledge of pathogenesis and clinical behavior of AAOLL are still scarce. OBJECTIVE: We investigated for the first time the use of LOH as a molecular approach for genetic characterization of AAOLL in comparison with OLP and evaluated the cell proliferation index. MATERIALS AND METHODS: The sample comprised nine AAOLLs, 10 OLPs and eight NOMs matched by patients' gender and age...
December 27, 2016: Oral Diseases
https://www.readbyqxmd.com/read/28026045/differentiating-regressed-melanoma-from-regressed-lichenoid-keratosis
#17
Aegean H Chan, Kenneth Shulman, Bonnie A Lee
BACKGROUND: Distinguishing regressed lichen planus-like keratosis (LPLK) from regressed melanoma can be difficult on histopathologic examination, potentially resulting in mismanagement of patients. OBJECTIVE: We aimed to identify histopathologic features by which regressed melanoma can be differentiated from regressed LPLK. METHODS: 20 actively inflamed LPLK, 12 LPLK with regression, and 15 melanomas with regression were compared and evaluated by H&E staining as well as Melan-A, MiTF, and cytokeratin (AE1/AE3) immunostaining...
December 27, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28000306/filaggrin-gene-mutations-and-the-distribution-of-filaggrin-in-oral-mucosa-of-patients-with-oral-lichen-planus-and-healthy-controls
#18
K R Larsen, J D Johansen, J Reibel, C Zachariae, K Rosing, A M L Pedersen
BACKGROUND: Lichen planus (LP) is a chronic inflammatory disease of unknown etiology affecting the skin and oral mucosa. Oral lichenoid lesions (OLL), like oral contact reactions, may resemble oral lichen planus (OLP) both clinically and histopathologically. As OLP and OLL are hyperkeratotic diseases and filaggrin is essential to keratinization the distribution of filaggrin may be altered in these lesions. OBJECTIVES: To investigate if patients with OLP/OLL have 1) altered distribution of filaggrin in the oral mucosa, 2) a higher incidence of mutations in the filaggrin gene (FLG) and 3) active dermatoses, apart from cutaneous LP, than healthy controls; and 4) patients with OLP/OLL and a defect in the FLG have more widespread oral lesions and report more symptoms than OLP/OLL patients without a concomitant defect in the FLG...
December 21, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27990397/unilateral-zosteriform-lichen-planus-involving-multiple-noncontiguous-dermatomes-with-oral-involvement
#19
Nidhi Jivani, Rahulkrishna S Kota, Pragya A Nair
No abstract text is available yet for this article.
November 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27990390/nekam-s-disease
#20
Chintaginjala Aruna, D V S B Ramamurthy, T Neelima, Haritha Bandaru
Keratosis lichenoides chronica also known as Nekam's disease is a rare mucocutaneous disorder, characterized clinically by asymptomatic violaceous keratotic papules arranged in linear, reticular, or plaque form usually on the trunk and extremities and histologically by interface dermatitis. The disease is considered rare with only 128 cases being reported in the literature till date and very few from India. We report a case of a 40-year-old man who presented with constellation of features of lichen planus, seborrheic dermatitis, and apthous ulcers, which upon workup was found to be Nekam's disease...
November 2016: Indian Dermatology Online Journal
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