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Lichen planus

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https://www.readbyqxmd.com/read/29341310/critical-appraisal-of-the-oxidative-stress-pathway-in-vitiligo-a-systematic-review-and-meta-analysis
#1
REVIEW
R Speeckaert, J Dugardin, J Lambert, H Lapeere, E Verhaeghe, M M Speeckaert, N van Geel
BACKGROUND: The pathogenesis of vitiligo remains a topic of extensive debate. This is partly due to the moderate efficacy of current treatments. The role of oxidative stress pathway in vitiligo is a popular although controversial research topic. OBJECTIVE: To clarify the role of the oxidative stress pathway in vitiligo compared to other inflammatory skin disorders and to assess the therapeutic role of antioxidants. METHODS: We conducted a systematic search of the existing literature on the aberrancies of the oxidative stress pathway in vitiligo...
January 17, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29335479/lps-induced-vitamin-d-receptor-decrease-in-oral-keratinocytes-is-associated-with-oral-lichen-planus
#2
Bin Zhao, Ran Li, Fang Yang, Feiyan Yu, Na Xu, Fang Zhang, Xuejun Ge, Jie Du
The suppressive function of vitamin D on oral lichen planus (OLP) have been documented previously. Vitamin D receptor (VDR) expression is down-regulated in OLP, but the molecular mechanism of its decrease and the related anti-inflammatory contributor of epithelial VDR signaling is unclear. Herein, we demonstrated that lipopolysaccharide (LPS) remarkedly down-regulated VDR expression of keratinocytes, and the reduced regulation was dependent on tumor necrosis factor alpha (TNFα)-miR-346 pathway. In human specimen studies, VDR levels of oral mucosal epithelia from OLP patients decreased substantially accompanied with robust TNFα and miR-346 induction, compared to the normal tissues...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330580/-lichen-ruber-planus-better-understanding-better-treatment
#3
REVIEW
L Schilling, T Vogt
Lichen ruber, also called lichen ruber planus or lichen planus (LP), is a noncontagious inflammatory skin disease. LP is the main representative and namesake of the group of lichenoid diseases, which are characterized by small papules often accompanied by severe itching. With 65% of cases, LP is primarily a disease of the mucous membranes. In 20% of the cases, the disease is found on the skin and mucous membranes; skin involvement alone is seen in only about 10% of cases. Cutaneous LP has a very favorable 1‑year prognosis of almost 80% healing as opposed to the mucosa and the adnexal organs...
January 12, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29328891/dysplasia-should-not-be-ignored-in-lichenoid-mucositis
#4
L D Rock, D M Laronde, I Lin, M P Rosin, B Chan, B Shariati, L Zhang
Oral lichen planus is categorized as a potentially malignant condition by the World Health Organization; however, some argue that only lichen planus with dysplasia have malignant potential. Many pathologists call lichen planus with dysplasia "dysplasia with lichenoid mucositis (LM)" or "LM with dysplasia." Previous research has shown that certain high-risk patterns of loss of heterozygosity (LOH) in dysplastic lesions are associated with significantly increased cancer risk. However, LM without dysplasia lacks such molecular patterns, supporting the hypothesis that LM, by itself, is not potentially malignant and that only those with dysplasia have malignant potential...
January 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29328529/hinokitiol-ablates-myofibroblast-activation-in-precancerous-oral-submucous-fibrosis-by-targeting-snail
#5
Hui-Wen Yang, Ming-Yi Lu, Yu-Wei Chiu, Yi-Wen Liao, Yu-Feng Huang, Pin Ju Chueh, Pei-Ling Hsieh, Cheng-Chia Yu
Oral submucous fibrosis (OSF) is a precancerous condition with symptoms of limited mouth opening and areca nut chewing habit has been implicated in its pathogenesis. Hinokitiol, a natural tropolone derived from Chamacyparis taiwanensis, has been reported to improve oral lichen planus and inhibit various cancer cells. Here, we showed that hinokitiol reduced the myofibroblast activities in fBMFs and prevented the arecoline-induced transdifferentiation. Treatment of hinokitiol dose-dependently downregulated the myofibroblast markers as well as various EMT transcriptional factors...
January 12, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29326823/lichen-planus-following-tetanus-diphtheria-acellular-pertussis-vaccination-a-case-report-and-review-of-the-literature
#6
Heather C Rosengard, Chikoti M Wheat, Matthew P Tilson, Jonathan D Cuda
Lichen planus is an inflammatory dermatosis with a prevalence of approximately 1%. Recent meta-analyses show that patients with hepatitis C virus have a 2.5- to 4.5-fold increased risk of developing lichen planus. Lichen planus has also followed vaccinations and has specifically been attributed to the hepatitis B vaccine, the influenza vaccine, and the tetanus-diphtheria-acellular pertussis vaccine. We describe a case of lichen planus in a hepatitis C virus-infected African American male occurring in temporal association with the administration of the tetanus-diphtheria-acellular pertussis vaccine...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29318582/nail-changes-in-alopecia-areata-an-update-and-review
#7
REVIEW
Khatiya Chelidze, Shari R Lipner
Nail changes are a common feature of alopecia areata (AA) and are a significant source of cosmetic disfigurement and functional impairment. This review provides an update of the prevalence, clinical and histopathological features, pathogenesis, differential diagnosis, clinical course, prognosis, and management of nail changes in patients with AA. Searches for peer-reviewed journal articles were conducted using the PubMed/MEDLINE database with the search terms "nail changes alopecia areata," "alopecia areata nails," and specific searches on "trachyonychia alopecia areata" and "pitting alopecia areata...
January 10, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29314294/participation-of-the-th17-response-in-the-pathogenesis-of-oral-lichen-planus
#8
R A Melo, L A B Silva, A N Fernades-Costa, B V B Monteiro, E J D Silveira, M C C Miguel
Lichen planus is a chronic noninfectious inflammatory mucocutaneous disease that affects the skin, nails and mucosae, including the oral mucosa.1 Although the etiology of oral liquen planus (OLP) remains not fully elucidated, it is recognized that its pathogenesis arises from an immune-mediated response and many authors suggest the disease to be an autoimmune process.2-5 Despite the high prevalence and well-defined cytotoxic activity of CD8+ T lymphocytes against keratinocytes of the basal layer of the epithelium in OLP, helper CD4+ T lymphocytes also play an important role in the pathogenesis of this disease...
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29308937/management-of-reticular-oral-lichen-planus-patients-with-burning-mouth-syndrome-like-oral-symptoms-a-pilot-study
#9
Daniela Adamo, Michele Davide Mignogna, Giuseppe Pecoraro, Massimo Aria, Giulio Fortuna
OBJECTIVES: We sought to determine the efficacy of psychotropic drug in the management of BMS-like oral symptoms in patients with reticular oral lichen planus (R-OLP) refractory to conventional therapies, and its impact on anxious and depressive symptoms. MATERIALS AND METHODS: We enrolled 28 cases of symptomatic R-OLP. The Numeric Rating Scale (NRS), the Total Pain Rating Index (T-PRI), the Hamilton rating scales for Depression (HAM-D) and Anxiety (HAM-A) were performed at baseline (time 0), after 2 months of topical clonazepam (time 1) and after six months of benzodiazepine and antidepressant drugs (time 2)...
January 8, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29301093/biomolecules-in-the-treatment-of-lichen-planus-refractory-to-corticosteroid-therapy-clinical-and-histopathological-assessment
#10
Laura Piñas, Mohammad Hamdan Alkhraisat, Ricardo Suárez Fernández, Eduardo Anitua
BACKGROUND: Local deficit of several biomolecules have been described in oral lichen planus (OLP). Such a deficit impairs cellular functions and cell-matrix communication. PURPOSE: Assess the efficacy of the local application of autologous biomolecules in the treatment of erosive OLP. MATERIALS AND METHODS: In this study, the use of plasma rich in growth factors (PRGF) as a source of blood-derived and autologous growth factors and proteins were tested in erosive oral lichen planus refractory to corticosteroids...
January 1, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29297958/randomized-placebo-controlled-double-blind-trial-of-clobetasol-propionate-0-05-in-the-treatment-of-oral-lichen-planus
#11
P G Arduino, M G Campolongo, V Sciannameo, D Conrotto, A Gambino, M Cabras, F Ricceri, S Carossa, R Broccoletti, M Carbone
OBJECTIVE: To perform a randomized, placebo-controlled, double-blind study, with a follow-up period of 6 months, for the use of topical clobetasol in cases of symptomatic oral lichen planus (OLP). SUBJECTS AND METHODS: Thirty-two participants were analyzed, with the aims of: (I) to compare the usefulness of topically applied clobetasol propionate 0.05% (mixed with 4% hydroxyethyl cellulose gel) and 4% hydroxyethyl cellulose gel alone (considered as placebo) in the management of OLP; (II) to describe which of them is quicker in decreasing signs and reported symptoms, and (III) which is able to give the proper longer remission in the follow-up...
January 3, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29288692/intraepithelial-cd8-lymphocytes-as-a-predictive-diagnostic-biomarker-for-the-remission-of-oral-lichen-planus
#12
Ai Enomoto, Eiichi Sato, Takashi Yasuda, Tatsuya Isomura, Toshitaka Nagao, Daichi Chikazu
Oral lichen planus (OLP) is an autoimmune inflammatory disease of the oral mucosa whose etiology remains unknown. Moreover, the possibility of OLP being a premalignant change is under debate. Various types of immune cells infiltrate the OLP lesion and affect its clinicopathological features. However, the diversity of infiltrating immune cells has not been fully clarified in relation to OLP diagnosis. In this study, we quantitatively examined CD8 (+) lymphocyte infiltration by immunohistochemistry, which is the principal effector of cytotoxic immune reaction in 123 cases of OLP specimens...
December 27, 2017: Human Pathology
https://www.readbyqxmd.com/read/29284468/evaluation-of-the-content-quality-of-websites-for-recurrent-aphthous-ulcers-and-oral-lichen-planus
#13
Xiaosheng Hu, Hui Pan, Wenxiu He, Hong Hua, Zhimin Yan
BACKGROUND: The Internet is one of the most popular resources for people to obtain medical information; however, only a limited number of studies have reported the quality of the available health information related to oral mucosal diseases. The present study aimed to evaluate the quality of information on websites for recurrent aphthous ulcers (RAU) and oral lichen planus (OLP), in both Chinese and English. METHODS: Common search engines, BaiDu, Google, and Yahoo in Chinese; and Bing, Google, and Yahoo in English were used to identify websites providing content related to the oral mucosal diseases...
December 29, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/29283460/a-novel-scale-for-measurement-of-acquired-dermal-macular-hyperpigmentation-adhm-severity
#14
Keshavamurthy Vinay, Garima Dabas, Davinder Parsad, Sendhil Kumaran Muthu
Acquired dermal macular hyperpigmentation (ADMH) is a hypernym which includes lichen planus pigmentosus (LPP), Riehl's melanosis (RM), pigmented contact dermatitis (PCD) and erythema dyschromicum perstans (EDP). There is considerable overlap between the clinical and histopathological features of these conditions. Despite affecting a large number of patients, there is no validated quantitative scale for LPP/EDP/RM/PCD/ADMH. This article is protected by copyright. All rights reserved.
December 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29282398/fenofibrate-induced-lichenoid-drug-eruption-a-rare-culprit
#15
Fayeza Mohammed, Laura L Wally, Jeffrey E Karaban, Vijaya B Reddy, Yongsuk Lertratanakul
A lichenoid drug eruption is a rare side effect which can occur following the administration of several different medications. Here we describe a unique case of fenofibrate as the causative agent of a lichenoid drug eruption. This case highlights a rare and clinically significant dermatologic side effect of fenofibrate. In addition, we report a potential familial association which underscores the potential for underlying genetic mechanisms to be contributory to lichenoid drug eruptions. A reminder of the physical characteristics of lichen planus, knowledge of the temporal relation between administration of medications and a lichenoid drug eruption, recognition of the effect of UV exposure on lichenoid drug eruptions, and realization for the potential of symptoms to persist despite discontinuation of an offending agent can aid practitioners in promptly diagnosing lichenoid drug eruptions and initiating appropriate therapy...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29282395/lichen-planus-pemphigoides-induced-by-enalapril-a-case-report-and-a-review-of-literature
#16
Woranit Onprasert, Kumutnart Chanprapaph
Lichen planus pemphigoides (LPP) is a rare autoimmune bullous dermatosis. The clinical presentation of LPP may mimic bullous pemphigoid making the diagnosis difficult. A thorough clinical, histopathological, and immunological evaluation is essential for the diagnosis of LPP. The etiology is largely idiopathic; however, there are several case reports of drug-induced LPP. We report an 81-year-old Thai woman with underlying hypertension and type 2 diabetes mellitus who presented with a 4-week history of multiple tense bullae initially on the hands and feet that subsequently expanded to the trunk and face...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29279685/psychological-factors-in-oral-mucosal-and-orofacial-pain-conditions
#17
REVIEW
Mohammad S Alrashdan, Mustafa Alkhader
The psychological aspects of chronic pain conditions represent a key component of the pain experience, and orofacial pain conditions are not an exception. In this review, we highlight how psychological factors affect some common oral mucosal and orofacial pain conditions (namely, oral lichen planus, recurrent aphthous stomatitis, burning mouth syndrome, and temporomandibular disorders) with emphasis on the significance of supplementing classical biomedical treatment modalities with appropriate psychological counseling to improve treatment outcomes in targeted patients...
October 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/29279568/rapid-detection-of-candida-albicans-in-oral-exfoliative-cytology-samples-by-loop-mediated-isothermal-amplification
#18
Hiroyasu Noguchi, Takashi Iwase, Daisuke Omagari, Masatake Asano, Ryota Nakamura, Kosuke Ueki, Keiji Shinozuka, Tadayoshi Kaneko, Morio Tonogi, Hiderou Ohki
Loop-mediated isothermal amplification (LAMP) rapidly amplifies DNA under isothermal conditions. The aim of this study was to detect Candida albicans and compare the positivity rate in the LAMP reaction with that of conventional methods for oral exfoliative cytology (EC) samples. Sixty-eight EC samples from 53 patients were subjected to LAMP analysis. These patients had been clinically diagnosed with leukoplakia, squamous cell carcinoma, oral lichen planus (OLP), stomatitis, oral candidiasis, and other malignancies...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/29276184/evaluation-of-the-mirna-146a-and-mirna-155-expression-levels-in-patients-with-oral-lichen-planus
#19
Fatemeh Ahmadi-Motamayel, Zeynab Bayat, Mehrdad Hajilooi, Soroosh Shahryar-Hesami, Ali Mahdavinezhad, Lida Samie, Ghasem Solgi
BACKGROUND: Oral Lichen Planus (OLP) is a chronic autoimmune disease that could be considered as a potential premalignant status. OBJECTIVE: To evaluate the miRNA-146a and miRNA-155 expression levels in patients with oral Lichen planus lesions compared to healthy subjects with normal oral mucosa. METHODS: Forty patients with oral lichen planus and 18 healthy age and gender-matched controls were recruited in this case-control study. Oral lichen planus was diagnosed clinically and pathologically...
December 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29274094/folliculotropism-in-pigmented-facial-macules-differential-diagnosis-with-reflectance-confocal-microscopy
#20
F Persechino, N De Carvalho, S Ciardo, B De Pace, A Casari, J Chester, S Kaleci, I Stanganelli, C Longo, F Farnetani, G Pellacani
Pigmented facial macules are common on sun damage skin. The diagnosis of early stage lentigo maligna (LM) and lentigo maligna melanoma (LMM) is challenging. Reflectance confocal microscopy (RCM) has been proven to increase diagnostic accuracy of facial lesions. A total 154 pigmented facial macules, retrospectively collected, were evaluate for the presence of already described RCM features and new parameters depicting aspects of the follicle . Melanocytic nests, roundish pagetoid cells, follicular infiltration, bulgings from the follicles and many bright dendrites, and infiltration of the hair follicle (i...
December 22, 2017: Experimental Dermatology
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