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https://www.readbyqxmd.com/read/29677705/in-house-validation-and-small-scale-collaborative-study-to-evaluate-analytical-performances-of-multi-mycotoxin-screening-methods-based-on-liquid-chromatography-high-resolution-mass-spectrometry-case-study-fusarium-toxins-in-wheat
#1
Biancamaria Ciasca, Michelangelo Pascale, Valerio Guido Altieri, Francesco Longobardi, Michele Suman, Dante Catellani, Veronica M T Lattanzio
A strong trend toward using highly selective mass spectrometry technologies for screening of multiple mycotoxins has been observed in recent years. In the present study, the process of validation of a multi-mycotoxin screening method based on liquid chromatography high-resolution mass spectrometry method is presented. The method was intended for the simultaneous screening of the major Fusarium toxins (deoxynivalenol, 3- and 15-acetyl deoxynivalenol, T-2 and HT-2 toxins, zearalenone, enniatins A, A1, B, B1, beauvericin) in wheat...
April 20, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29677601/indirect-detection-of-10-b-i-3-overtone-nmr-at-very-fast-magic-angle-spinning
#2
Nghia Tuan Duong, Ilya Kuprov, Yusuke Nishiyama
The application of overtone nuclear magnetic resonance (OT NMR) to symmetric spin transitions of integer quadrupolar nuclei is of considerable interest since this transition is immune to the first-order quadrupolar interaction, thus resulting in narrow NMR lines. Owing to its roles in nature and its high natural abundance, 14 N (I = 1) OT NMR has been explored, in which the indirect and/or direct acquisitions of 14 N OT were experimentally demonstrated. However, other than 14 N nucleus, no OT NMR observation of other integer quadrupolar nuclei has been reported in the literature...
April 11, 2018: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29677553/developmental-change-in-tone-perception-in-mandarin-monolingual-english-monolingual-and-mandarin-english-bilingual-infants-divergences-between-monolingual-and-bilingual-learners
#3
Leher Singh, Charlene S L Fu, Xian Hui Seet, Ashley P Y Tong, Joelle L Wang, Catherine T Best
Most languages use lexical tone to discriminate the meanings of words. There has been recent interest in tracking the development of tone categories during infancy. These studies have focused largely on monolingual infants learning either a tone language or a non-tone language. It remains to be seen how bilingual infants learning one tone language (e.g., Mandarin) and one non-tone language (e.g., English) discriminate tones. Here, we examined infants' discrimination of two Mandarin tones pairs: one salient and one subtle...
April 17, 2018: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29677173/what-does-this-mutation-mean-the-tools-and-pitfalls-of-variant-interpretation-in-lymphoid-malignancies
#4
REVIEW
Guillermin Yann, Lopez Jonathan, Chabane Kaddour, Hayette Sandrine, Bardel Claire, Salles Gilles, Sujobert Pierre, Huet Sarah
High throughput sequencing (HTS) is increasingly important in determining cancer diagnoses, with subsequent prognostic and therapeutic implications. The biology of cancer is becoming increasingly deciphered and it is clear that therapy needs to be individually tailored. Whilst translational research plays an important role in lymphoid malignancies, few guidelines exist to guide biologists and routine laboratories through this constantly evolving field. In this article, we review the challenges of interpreting HTS in lymphoid malignancies and provide a toolkit to interpret single nucleotide variants obtained from HTS...
April 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29677041/nontraditional-academic-community-partnership-a-survey-of-student-knowledge-and-competencies
#5
Eileen Sarsfield, Agnes Burkhard
This pilot study examined student perceptions of the acquisition of core knowledge and basic community/public health generalist competencies gained through an innovative, nontraditional clinical partnership with an organization serving a vulnerable population. The Centers for Disease Control and Prevention Workplace Health Model was the conceptual framework. A survey, based on the Essentials of Baccalaureate Nursing Education for Entry Level Community/Public Health Nursing Practice, was completed by 25 BSN nursing students...
April 19, 2018: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29676963/pictorial-review-of-digital-radiography-artifacts
#6
Alisa I Walz-Flannigan, Kimberly J Brossoit, Dayne J Magnuson, Beth A Schueler
Visual familiarity with the variety of digital radiographic artifacts is needed to identify, resolve, or prevent image artifacts from creating issues with patient imaging. Because the mechanism for image creation is different between flat-panel detectors and computed radiography, the causes and appearances of some artifacts can be unique to these different modalities. Examples are provided of artifacts that were found on clinical images or during quality control testing with flat-panel detectors. The examples are meant to serve as learning tools for future identification and troubleshooting of artifacts and as a reminder for steps that can be taken for prevention...
April 20, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29676794/classify-epithelium-stroma-in-histopathological-images-based-on-deep-transferable-network
#7
X Yu, H Zheng, C Liu, Y Huang, X Ding
Recently, the deep learning methods have received more attention in histopathological image analysis. However, the traditional deep learning methods assume that training data and test data have the same distributions, which causes certain limitations in real-world histopathological applications. However, it is costly to recollect a large amount of labeled histology data to train a new neural network for each specified image acquisition procedure even for similar tasks. In this paper, an unsupervised domain adaptation is introduced into a typical deep convolutional neural network (CNN) model to mitigate the repeating of the labels...
April 20, 2018: Journal of Microscopy
https://www.readbyqxmd.com/read/29676347/dual-energy-computed-tomography-a-reliable-and-established-tool-for-in-vivo-differentiation-of-uric-acid-from-nonuric-acid-renal-stones
#8
Mohd Ilyas, Ghanshyam Dev, Anchal Gupta, Tameem Ahmad Bhat, Shwait Sharma
Background: Dual-energy computed tomography (DECT) utilises the technique of simultaneous image acquisition of a body part at two different energy levels of the X-ray tubes. We used the DECT in this project to study its accuracy in non-invasive in vivo differentiation of uric acid (UA) calculi from non-UA calculi using the 3rd generation dual-source computed tomography (CT) scanner. Materials and Methods: The DECT ratios of the various stones were noted and compared with the postextraction analysis of stones for composition...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29676341/the-prevalence-and-risk-factors-for-trichomonas-vaginalis-infection-amongst-human-immunodeficiency-virus-infected-pregnant-women-attending-the-antenatal-clinics-of-a-university-teaching-hospital-in-lagos-south-western-nigeria
#9
Olaolopin Ijasan, Kehinde Sharafadeen Okunade, Ayodeji Ayotunde Oluwole
Background: Trichomonas vaginalis infection is the most prevalent non-viral sexually transmitted infection worldwide. Interactions between this infection and human immunodeficiency virus (HIV) may cause adverse pregnancy outcomes such as preterm labour, premature rupture of membranes, chorioamnionitis, low birth weight and post-abortal sepsis. Aims: This study was aimed to determine the prevalence and risk factors of T. vaginalis infection amongst HIV-positive pregnant women attending antenatal care at the Lagos University Teaching Hospital (LUTH), Lagos, Nigeria...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29676283/a-combined-positron-emission-tomography-pet-electron-paramagnetic-resonance-imaging-epri-system-initial-evaluation-of-a-prototype-scanner
#10
Mark Tseytlin, Alexander V Stolin, Priyaankadevi Guggilapu, Andrey A Bobko, Valery V Khramtsov, Oxana Tseytlin, Raymond R Raylman
The advent of hybrid scanners, combining complementary modalities, has revolutionized imaging; enhancing clinical practice and biomedical research. In this project, we investigated the melding of two complementary, functional imaging methods: positron emission tomography (PET) and electron paramagnetic resonance imaging (EPRI). The PET radiotracers can provide important information about cellular parameters, such as glucose metabolism. While EPR probes can provide assessment of tissue microenvironment, measuring parameters such as oxygenation and pH, for example...
April 20, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29676250/plasmodium-falciparum-resistance-to-artemisinin-based-combination-therapies-a-sword-of-damocles-in-the-path-toward-malaria-elimination
#11
Manel Ouji, Jean-Michel Augereau, Lucie Paloque, Françoise Benoit-Vical
The use of artemisinin-based combination therapies (ACTs), which combine an artemisinin derivative with a partner drug, in the treatment of uncomplicated malaria has largely been responsible for the significant reduction in malaria-related mortality in tropical and subtropical regions. ACTs have also played a significant role in the 18% decline in the incidence of malaria cases from 2010 to 2016. However, this progress is seriously threatened by the reduced clinical efficacy of artemisinins, which is characterised by delayed parasitic clearance and a high rate of recrudescence, as reported in 2008 in Western Cambodia...
2018: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/29676240/motion-management-in-pet-ct-technological-solutions
#12
Elena De Ponti, Sabrina Morzenti, Cinzia Crivellaro, Federica Elisei, Andrea Crespi, Luca Guerra
BACKGROUND: Motion due to patient's breathing can introduce heavy bias in PET/CT, both in image quality and quantification. AIM: To review technical aspects of the main solutions available to manage movement in PET/CT studies. METHODS: The following tools were described: Respiratory Gated (RG), Motion Free (MF), End Expiration (EE), Banana Artefact Management (BAM) and Data Driven Gating (DDG). RESULTS: The most diffused solutions (RG, MF, EE) are based on LIST mode acquisition of a PET Field of View (4D FOV), centered on the anatomical region of interest; to link PET data not only to time and to spatial position but also to the corresponding breathing phase, the synchronized acquisition of the patient's breathing curve is performed by an external tracking device...
April 19, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29676169/thirty-minutes-of-running-exercise-decreases-t2-signal-intensity-but-not-thickness-of-the-knee-joint-cartilage-a-3-0-t-magnetic-resonance-imaging-study
#13
Yiğitcan Karanfil, Naila Babayeva, Gürhan Dönmez, H Barış Diren, Muzaffer Eryılmaz, Mahmut Nedim Doral, Feza Korkusuz
Objective Recent studies showed a potential of magnetic resonance imaging (MRI), which can be used as an additional tool for diagnosing cartilage degeneration in the early stage. We designed a cross-sectional study in order to evaluate knee joint cartilage adaptation to running, using 3.0-T MRI equipped with the 3-dimensional turbo spin echo (VISTA = Volume ISotropic Turbo spin echo Acquisition) software. By this thickness (mm) and signal intensity (mean pixel value) can be quantified, which could be closely related to the fluid content of the knee joint cartilage, before and after running...
April 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29676025/an-unsupervised-automatic-segmentation-algorithm-for-breast-tissue-classification-of-dedicated-breast-computed-tomography-images
#14
Marco Caballo, John M Boone, Ritse Mann, Ioannis Sechopoulos
PURPOSE: To develop and evaluate a new automatic classification algorithm able to identify voxels containing skin, vasculature, adipose and fibroglandular tissue in dedicated breast CT images. METHODS: The proposed algorithm combines intensity and region-based segmentation methods with energy minimizing splines and unsupervised data mining approaches for classifying and segmenting the different tissue types. Breast skin segmentation is achieved by a region growing method which uses constraints from the previously extracted skin centerline to add robustness to the model and to reduce the false positive rate...
April 19, 2018: Medical Physics
https://www.readbyqxmd.com/read/29675953/stimulus-presentation-order-in-receptive-identification-tasks-a-systematic-replication
#15
Kiley A Schneider, Bailey Devine, Gabriella Aguilar, Anna Ingeborg Petursdottir
Conflicting recommendations exist in the literature regarding the optimal order of stimulus presentation when teaching auditory-visual conditional discriminations. The present study examined the generality of a previously demonstrated advantage of presenting the auditory sample before visual comparisons (sample-first condition) over the reverse sequence (comparison-first condition). Participants were four typically developing 5- and 6-year-old boys. The procedures of Petursdottir and Aguilar (2016) were systematically replicated with the addition of a prompted error correction trial following each incorrect response...
April 19, 2018: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/29675919/therapy-and-outcome-of-staphylococcus-aureus-infections-of-intracorporeal-ventricular-assist-devices
#16
Miquel B Ekkelenkamp, Mats T Vervoorn, Jumamurat R Bayjanov, Ad C Fluit, Barry J Benaissa-Trouw, Faiz Z Ramjankhan
Infection of the driveline or pump pocket is a common complication in patients with ventricular assist devices (VADs) and Staphylococcus aureus is the main pathogen causing such infections. Limited evidence is currently available to guide the choice of antibiotic therapy and the duration of treatment in these patients. Patients at the University Medical Center Utrecht who developed a VAD-related S. aureus infection between 2007 and 2016 were retrospectively assessed. Blood culture isolates were typed by whole genome sequencing to differentiate between relapses and reinfections, and to determine whether antibiotic therapy had led to acquisition of resistance mutations...
April 19, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29675539/lab-on-a-tip-atomic-force-microscopy-photothermal-infrared-spectroscopy-of-atmospherically-relevant-organic-inorganic-aerosol-particles-in-the-nanometer-to-micrometer-size-range
#17
Victor W Or, Armando D Estillore, Alexei V Tivanski, Vicki H Grassian
New developments in nanoscale analytical techniques have paved the way for detailed spectroscopic and microscopic measurements of substrate-deposited aerosol particles on a single particle basis. Atomic force microscopy based photothermal infrared (AFM-PTIR) spectroscopy is a technique that combines the nanometer spatial resolution of AFM with the chemical analysis capabilities of vibrational IR spectroscopy. Herein we demonstrate the capability of AFM-PTIR to investigate single and multi-component systems comprised of inorganic salts and organic compounds relevant to the atmosphere...
April 20, 2018: Analyst
https://www.readbyqxmd.com/read/29675413/influence-of-the-size-and-curvedness-of-neural-projections-on-the-orientationally-averaged-diffusion-mr-signal
#18
Evren Özarslan, Cem Yolcu, Magnus Herberthson, Hans Knutsson, Carl-Fredrik Westin
Neuronal and glial projections can be envisioned to be tubes of infinitesimal diameter as far as diffusion magnetic resonance (MR) measurements via clinical scanners are concerned. Recent experimental studies indicate that the decay of the orientationally-averaged signal in white-matter may be characterized by the power-law, Ē ( q ) ∝ q -1 , where q is the wavenumber determined by the parameters of the pulsed field gradient measurements. One particular study by McKinnon et al . [1] reports a distinctively faster decay in gray-matter...
2018: Frontiers in Physics
https://www.readbyqxmd.com/read/29675398/metabolic-reprogramming-during-multidrug-resistance-in-leukemias
#19
Raphael Silveira Vidal, Julia Quarti, Franklin D Rumjanek, Vivian M Rumjanek
Cancer outcome has improved since introduction of target therapy. However, treatment success is still impaired by the same drug resistance mechanism of classical chemotherapy, known as multidrug resistance (MDR) phenotype. This phenotype promotes resistance to drugs with different structures and mechanism of action. Recent reports have shown that resistance acquisition is coupled to metabolic reprogramming. High-gene expression, increase of active transport, and conservation of redox status are one of the few examples that increase energy and substrate demands...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29675354/quantification-of-liver-iron-concentration-using-the-apparent-susceptibility-of-hepatic-vessels
#20
Saifeng Liu, Chaoyue Wang, Xiaoqi Zhang, Panli Zuo, Jiani Hu, E Mark Haacke, Hongyan Ni
Background: The quantification of liver iron concentration (LIC) is important for the monitoring of the body iron level in patients with iron overload. Conventionally, LIC is quantified through R2 or R2* mapping using MRI. In this paper, we demonstrate an alternative approach for LIC quantification through measuring the apparent susceptibility of hepatic vessels using quantitative susceptibility mapping (QSM). Methods: QSM was performed in the liver region with the iterative susceptibility weighted imaging and mapping (iSWIM) algorithm, using the geometry of the vessels extracted from magnitude images as constraints...
March 2018: Quantitative Imaging in Medicine and Surgery
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