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https://www.readbyqxmd.com/read/29055059/application-of-the-bbcid-mass-spectrometry-approach-for-protein-glycosylation-and-phosphorylation-analysis
#1
Narciso Couto, Liliya Davlyatova, Caroline A Evans, Phillip C Wright
RATIONALE: Post-translational modified peptides analysis by mass spectrometry (MS) remains incomplete, in part due to incomplete sampling of all peptides which is inherent to traditional data-dependent acquisition (DDA). An alternative MS approach, data-independent acquisition (DIA), enables comprehensive recording of all detectable precursor and product ions, independent of precursor intensity. The use of broad band collision-induced dissociation (bbCID), a DIA method, was evaluated for the identification of protein glycosylation and phosphorylation...
October 21, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29055058/the-neural-oscillations-of-speech-processing-and-language-comprehension-state-of-the-art-and-emerging-mechanisms
#2
Lars Meyer
Neural oscillations subserve a broad range of functions in speech processing and language comprehension. On the one hand, speech contains-somewhat-repetitive trains of air pressure bursts that occur at three dominant amplitude modulation frequencies, physically marking the linguistically meaningful progressions of phonemes, syllables, and intonational phrase boundaries. To these acoustic events, neural oscillations of isomorphous operating frequencies are thought to synchronize, presumably resulting in an implicit temporal alignment of periods of neural excitability to linguistically meaningful spectral information on the three low-level linguistic description levels...
October 20, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29055050/an-evolutionary-framework-outlining-the-integration-of-individual-social-and-spatial-ecology
#3
REVIEW
Quinn M R Webber, Eric Vander Wal
1.Behaviour is the interface between an organism and its environment, and behavioural plasticity is important for organisms to cope with environmental change. Social behaviour is particularly important because sociality is a dynamic process, where environmental variation influences group dynamics and social plasticity can mediate resource acquisition. Heterogeneity in the ecological environment can therefore influence the social environment. The combination of the ecological and social environments may be interpreted collectively as the 'socioecological' environment', which could explain variation in fitness...
October 21, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29054879/domain-specificity-of-oculomotor-learning-after-changes-in-sensory-processing
#4
Yuliy Tsank, Miguel P Eckstein
Humans visually process the world with varying spatial resolution and can program their eye movements optimally to maximize information acquisition for a variety of everyday tasks. Diseases such as macular degeneration can change visual sensory processing, introducing central vision loss (a scotoma). However, humans can learn to direct a new preferred retinal location to regions of interest for simple visual tasks. Whether such learned compensatory saccades are optimal and generalize to more complex tasks, which require integrating information across a large area of the visual field, is not well-understood...
October 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29054834/evaluation-of-web-based-continuing-professional-development-courses-aggregate-mixed-methods-model
#5
Arezoo Ebn Ahmady, Megan Barker, Myra Fahim, Rosa Dragonetti, Peter Selby
BACKGROUND: Many continuing professional development (CPD) Web-based programs are not explicit about underlying theory and fail to demonstrate impact. OBJECTIVE: The aim of this study was to develop and apply an aggregate mixed-methods evaluation model to describe the paradigm, theoretical framework, and methodological approaches used to evaluate a CPD course in tobacco dependence treatment, the Training Enhancement in Applied Cessation Counseling and Health (TEACH) project...
October 20, 2017: JMIR Medical Education
https://www.readbyqxmd.com/read/29054819/high-ambient-temperature-facilitates-the-acquisition-of-3-4-methylenedioxymethamphetamine-mdma-self-administration
#6
Shawn M Aarde, Pai-Kai Huang, Michael A Taffe
RATIONALE: MDMA alters body temperature in rats with a direction that depends on the ambient temperature (TA). The thermoregulatory effects of MDMA and TA may affect intravenous self-administration (IVSA) of MDMA but limited prior reports conflict. OBJECTIVE: To determine how body temperature responses under high and low TA influence MDMA IVSA. METHODS: Male Sprague-Dawley rats were trained to IVSA MDMA (1.0mg/kg/infusion; 2-h sessions; FR5 schedule of reinforcement) under TA 20°C or 30°C...
October 17, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29054737/a-novel-dti-qa-tool-automated-metric-extraction-exploiting-the-sphericity-of-an-agar-filled-phantom
#7
Sofia Chavez, Joseph Viviano, Mojdeh Zamyadi, Peter B Kingsley, Peter Kochunov, Stephen Strother, Aristotle Voineskos
PURPOSE: To develop a quality assurance (QA) tool (acquisition guidelines and automated processing) for diffusion tensor imaging (DTI) data using a common agar-based phantom used for fMRI QA. The goal is to produce a comprehensive set of automated, sensitive and robust QA metrics. METHODS: A readily available agar phantom was scanned with and without parallel imaging reconstruction. Other scanning parameters were matched to the human scans. A central slab made up of either a thick slice or an average of a few slices, was extracted and all processing was performed on that image...
October 17, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29054720/a-randomized-comparison-of-two-robotic-virtual-reality-simulators-and-evaluation-of-trainees-skills-transfer-to-a-simulated-robotic-urethrovesical-anastomosis-task
#8
Jen Hoogenes, Nathan Wong, Badr Al-Harbi, Kevin S Kim, Saahil Vij, Elisa Bolognone, Mackenzie Quantz, Yanbo Guo, Bobby Shayegan, Edward D Matsumoto
OBJECTIVE: To determine, via a randomized comparison study, whether robotic simulator-acquired skills transfer to performance of a urethrovesical anastomosis (UVA) on a 3D-printed bladder model using the da Vinci Robot. MATERIALS AND METHODS: Medical students, surgical residents, and fellows were recruited and divided into two groups: G1 (junior trainees) and G2 (senior trainees). Participants were randomized to identical simulator training curricula on the dV-Trainer (dV-T) or da Vinci Surgical Skills Simulator (dVSSS)...
October 17, 2017: Urology
https://www.readbyqxmd.com/read/29054591/us-alone-trials-presented-during-acquisition-do-not-disrupt-classical-eyeblink-conditioning-empirical-and-computational-findings
#9
M T Allen, C E Myers, D Williams, R J Servatius
Studies of partial reinforcement in eyeblink conditioning have typically shown slower learning of a CS-US association when paired CS-US trials are interleaved with CS-alone trials. However, recent work has shown that CS-US learning is not slowed by interleaved US-alone trials. This discrepancy is surprising since both partial reinforcement protocols reduce the total number of paired CS-US trials. Previously, Kimble et al. (1955) reported that inserting a block of US-alone trials during CS-US training did not disrupt eyeblink acquisition...
October 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29054412/regulatory-mechanisms-for-iron-transport-across-the-blood-brain-barrier
#10
Kari A Duck, Ian A Simpson, James R Connor
Many critical metabolic functions in the brain require adequate and timely delivery of iron. However, most studies when considering brain iron uptake have ignored the iron requirements of the endothelial cells that form the blood-brain barrier (BBB). Moreover, current models of BBB iron transport do not address regional regulation of brain iron uptake or how neurons, when adapting to metabolic demands, can acquire more iron. In this study, we demonstrate that both iron-poor transferrin (apo-Tf) and the iron chelator, deferoxamine, stimulate release of iron from iron-loaded endothelial cells in an in vitro BBB model...
October 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29054165/the-origin-of-bipedality-as-the-result-of-a-developmental-by-product-the-case-study-of-the-olive-baboon-papio-anubis
#11
François Druelle, Peter Aerts, Gilles Berillon
In this paper, we point to the importance of considering infancy in the emergence of new locomotor modes during evolution, and particularly when considering bipedal walking. Indeed, because infant primates commonly exhibit a more diverse posturo-locomotor repertoire than adults, the developmental processes of locomotion represent an important source of variation upon which natural selection may act. We have had the opportunity to follow the development of locomotion in captive individuals of a committed quadrupedal primate, the olive baboon (Papio anubis)...
December 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/29054151/enhanced-ms-ms-coverage-for-metabolite-identification-in-lc-ms-based-untargeted-metabolomics-by-target-directed-data-dependent-acquisition-with-time-staggered-precursor-ion-list
#12
Yang Wang, Ruibing Feng, Ruibing Wang, Fengqing Yang, Peng Li, Jian-Bo Wan
Metabolite identification is one of the major bottlenecks in liquid chromatography-mass spectrometry (LC-MS)-based untargeted metabolomics owing to the difficulty of acquiring MS/MS information of most metabolites detected. Data dependent acquisition (DDA) has been currently used to acquire MS/MS data in untargeted metabolomics. When dealing with the complex biological samples, top-n-based DDA method selects only a small fraction of the ions for fragmentation, leading to low MS/MS coverage of metabolites in untargeted metabolomics...
November 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29054129/bioplex-display-an-interactive-suite-for-large-scale-ap-ms-protein-protein-interaction-data
#13
Devin K Schweppe, Edward L Huttlin, J Wade Harper, Steven P Gygi
The development of large-scale datasets requires new means to display and disseminate research studies to large audiences. Knowledge of protein-protein interaction (PPI) networks has become a principle interest of many groups within the field of proteomics. At the confluence of technologies, such as cross-linking mass spectrometry, yeast two-hybrid, protein co-fractionation, and affinity purification mass spectrometry (AP-MS), detection of protein-protein interactions can uncover novel biological inferences at a high-throughput...
October 20, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29054075/evaluation-of-immunological-markers-of-ovine-vaginal-irritation-implications-for-preclinical-assessment-of-non-vaccine-hiv-preventive-agents
#14
Gregg N Milligan, Gracie Vargas, Kathleen L Vincent, Yong Zhu, Nigel Bourne, Massoud Motamedi
The presence of genital inflammatory responses and a compromised vaginal epithelial barrier have been linked to an increased risk of HIV acquisition. It is important to assure that application of candidate microbicides designed to limit HIV transmission will not cause these adverse events. We previously developed high resolution in vivo imaging methodologies in sheep to assess epithelial integrity following vaginal application of a model microbicide, however characterization of genital inflammation in sheep has not been previously possible...
October 13, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29054073/discourse-production-of-mandarin-speaking-children-with-high-functioning-autism-the-effect-of-mental-and-action-verbs-semantic-pragmatic-features
#15
Yiqi Song, Zhongheng Jia, Shunhua Liu, Dandan Liang
The present study investigated the syntactic and pragmatic performance of children with high-functioning autism (HFA) during a discourse production task with mental verbs. Children with HFA and typically developing (TD) children were matched by chronological age, verbal IQ (VIQ) and full-scale IQ (FIQ). We found that children with HFA tended to select a nominal object given a mental verb with either a nominal or clausal object. They committed few syntactic errors but generated syntactic stereotypes with mental verbs...
October 16, 2017: Journal of Communication Disorders
https://www.readbyqxmd.com/read/29054037/director-field-analysis-dfa-exploring-local-white-matter-geometric-structure-in-diffusion-mri
#16
Jian Cheng, Peter J Basser
In Diffusion Tensor Imaging (DTI) or High Angular Resolution Diffusion Imaging (HARDI), a tensor field or a spherical function field (e.g., an orientation distribution function field), can be estimated from measured diffusion weighted images. In this paper, inspired by the microscopic theoretical treatment of phases in liquid crystals, we introduce a novel mathematical framework, called Director Field Analysis (DFA), to study local geometric structural information of white matter based on the reconstructed tensor field or spherical function field: (1) We propose a set of mathematical tools to process general director data, which consists of dyadic tensors that have orientations but no direction...
October 11, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/29053889/optimization-of-mass-spectrometry-acquisition-parameters-for-determination-of-polycarbonate-additives-degradation-products-and-colorants-migrating-from-food-contact-materials-to-chocolate
#17
Chiara Bignardi, Antonella Cavazza, Carmen Laganà, Paola Salvadeo, Claudio Corradini
The interest towards the so-called "substances of emerging concerns", in particular referred to objects intended to come into contact with food is recently growing. Such substances can be found in traces in simulants and in food products put in contact with plastic materials. In this context, it is important to set up analytical systems characterized by high sensitivity, and to improve detection parameters to enhance signals. This work was aimed at optimizing a method based on UHPLC coupled to High Resolution Mass Spectrometry to quantify the most common plastic additives, and able to detect the presence of polymers degradation products and coloring agents migrating from plastic re-usable containers...
October 20, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29053528/collaborative-testing-using-quizzes-as-a-method-to-improve-undergraduate-nursing-student-engagement-and-interaction
#18
Adriane Burgess, Michelle Medina-Smuck
Alternative testing methods are gaining popularity as an innovative means of assessing learning and retention of knowledge. Collaborative testing, an alternative to traditional testing, fosters interaction and collaboration among students. This article describes the use of collaborative testing using quizzes in an accelerated second-degree baccalaureate nursing program in order to enhance learning and retention of course content. Feedback from students was overwhelmingly positive, and most believed this strategy provided a structured method to their studying and acquisition of course concepts, which was particularly beneficial within an accelerated course format...
October 20, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29053451/spatially-resolved-mr-compatible-doppler-ultrasound-proof-of-concept-for-triggering-of-diagnostic-quality-cardiovascular-mri-for-function-and-flow-quantification-at-3t
#19
Lindsey A Crowe, Gibran Manasseh, Aneta Chmielewski, Anne-Lise Hachulla, Daniel Speicher, Andreas Greiser, Hajo Muller, Thomas De Perrot, Jean-Paul Vallee, Rares Salomir
OBJECTIVES: We demonstrate the use of a Magnetic-Resonance (MR)-compatible ultrasound (US) imaging probe using spatially-resolved Doppler for diagnostic quality cardiovascular MR imaging as an initial step towards hybrid US/MR fetal imaging. METHODS: A newly developed technology for a dedicated MR-compatible phased array ultrasound-imaging probe acquired pulsed color Doppler carotid images, which were converted in near-real time to a trigger signal for cardiac cine and flow quantification MRI...
October 17, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29053449/thermo-acoustic-ultrasound-for-detection-of-rf-induced-device-lead-heating-in-mri
#20
Neerav Dixit, Pascal P Stang, John M Pauly, Greig C Scott
Patients who have implanted medical devices with long conductive leads are often restricted from receiving MRI scans due to the danger of RF-induced heating near the lead tips. Phantom studies have shown that this heating varies significantly on a case-by-case basis, indicating that many patients with implanted devices can receive clinically useful MRI scans without harm. However, the difficulty of predicting RF-induced lead tip heating prior to scanning prevents numerous implant recipients from being scanned...
October 17, 2017: IEEE Transactions on Medical Imaging
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