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https://www.readbyqxmd.com/read/29241024/age-and-gender-associated-liver-physiological-t1rho-dynamics-demonstrated-with-a-clinically-applicable-single-breathhold-acquisition
#1
Yì Xiáng J Wáng, Min Deng, Jiang Lin, Anthony W L Kwok, Eric K W Liu, Weitian Chen
To understand women's and men's physiological ranges of liver T1rho relaxation time measured with a single breathhold black blood sequence, this healthy volunteer study was conducted in 62 women (mean age, 38.9 y; range, 18-75 y) and 34 men (mean age, 44.7 y; range, 24-80 y). Approval from the institutional ethics committee was obtained. Magnetic resonance imaging was performed with a 3.0T scanner with six spin-lock times of 0, 10, 20, 25, 35, and 50 ms and a single breathhold of 12 s per slice acquisition...
December 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/29240977/broadband-homonuclear-decoupled-hsqmbc-methods
#2
István Timári, Katalin E Kövér
Long-range heteronuclear coupling constants convey invaluable information for stereochemical and conformational analysis of molecules from synthetic and natural origin. Here we report a real-time Zangger-Sterk CPMG-HSQMBC method for the precise and direct measurement of multiple-bond heteronuclear couplings. It is demonstrated that the real-time acquisition strategy combined with multiple slice selective excitation can provide substantial improvement in sensitivity (or reduction of experimental time) as compared to other variants of broadband homonuclear decoupled HSQMBC methods published previously...
December 14, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29240881/nrf2-promotes-mutant-k-ras-p53-driven-pancreatic-carcinogenesis
#3
Shin Hamada, Keiko Taguchi, Atsushi Masamune, Masayuki Yamamoto, Tooru Shimosegawa
The Keap1-Nrf2 system contributes to the maintenance of homeostasis by regulating oxidative stress responses in normal tissues and organs, and is exploited in various cancers for proliferation, survival and acquisition of therapy resistance. Pancreatic cancer remains one of the intractable cancers, despite the improved clinical outcomes of other types of cancer, due to its invasive and refractory nature to therapeutic intervention. The current study aimed to clarify the contribution of Nrf2 to pancreatic carcinogenesis using a pancreas-specific mutant K-ras and p53 (KPC) mouse model...
June 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29240860/cost-per-additional-responder-associated-with-ixekizumab-and-etanercept-in-the-treatment-of-moderate-to-severe-psoriasis
#4
Steven R Feldman, Shonda A Foster, Baojin Zhu, Russel Burge, Sarah Al Sawah, Orin M Goldblum
<p>BACKGROUND: Newer psoriasis treatments can achieve greater levels of effcacy than older systemic therapies; however, current pso-riasis costs are substantial. We sought to estimate costs per additional responder associated with ixekizumab and etanercept, versus placebo, using effcacy data from phase 3 clinical trials (UNCOVER-2 and UNCOVER-3).</p> <p>METHODS: In UNCOVER-2/UNCOVER-3, patients received subcutaneous placebo, etanercept 50 mg twice weekly (BIW), or ixekizumab one 80 mg injection every 2 weeks (Q2W) after a 160-mg starting dose...
December 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29240773/polypyridylruthenium-ii-complexes-exert-anti-schistosome-activity-and-inhibit-parasite-acetylcholinesterases
#5
Madhu K Sundaraneedi, Bemnet Tedla, Ramon M Eichenberger, Luke Becker, Darren Pickering, Michael J Smout, Siji Rajan, Phurpa Wangchuk, F Richard Keene, Alex Loukas, J Grant Collins, Mark S Pearson
BACKGROUND: Schistosomiasis affects over 200 million people and there are concerns whether the current chemotherapeutic control strategy (periodic mass drug administration with praziquantel (PZQ)-the only licenced anti-schistosome compound) is sustainable, necessitating the development of new drugs. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the anti-schistosome efficacy of polypyridylruthenium(II) complexes and showed they were active against all intra-mammalian stages of S...
December 14, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29240700/high-speed-video-system-for-micro-expression-detection-and-recognition
#6
Diana Borza, Radu Danescu, Razvan Itu, Adrian Darabant
Micro-expressions play an essential part in understanding non-verbal communication and deceit detection. They are involuntary, brief facial movements that are shown when a person is trying to conceal something. Automatic analysis of micro-expression is challenging due to their low amplitude and to their short duration (they occur as fast as 1/15 to 1/25 of a second). We propose a fully micro-expression analysis system consisting of a high-speed image acquisition setup and a software framework which can detect the frames when the micro-expressions occurred as well as determine the type of the emerged expression...
December 14, 2017: Sensors
https://www.readbyqxmd.com/read/29240644/monocyte-function-and-clinical-outcomes-in-febrile-and-afebrile-patients-with-severe-sepsis
#7
Anne M Drewry, Enyo A Ablordeppey, Ellen T Murray, Catherine M Dalton, Brian M Fuller, Marin H Kollef, Richard S Hotchkiss
INTRODUCTION: Absence of fever is associated with higher mortality in septic patients, but the reason for this is unknown. Immune dysfunction may be a potential link between failure to mount a fever and poor outcomes. The purpose of this study was to evaluate monocyte function and clinical surrogates of immunity (i.e. mortality and acquisition of secondary infections) in febrile and afebrile septic patients. METHODS: Single-center, prospective cohort study of 92 critically ill septic patients...
December 13, 2017: Shock
https://www.readbyqxmd.com/read/29240589/infrared-skin-thermometry-validating-and-comparing-techniques-to-detect-periwound-skin-infection
#8
Asfandyar Mufti, Ranjani Somayaji, Patricia Coutts, R Gary Sibbald
OBJECTIVE: Diagnosis of wound infection can be challenging because it relies on a combination of clinical signs and symptoms that are often nonspecific. Increased periwound cutaneous temperature is a classic sign of deep and surrounding wound infection, and its quantitative measurement is one of the most reliable and valid clinical signs of deep and surrounding skin infection at the bedside. Skin surface temperature differences may be detected using commercially available noncontact infrared thermometers...
January 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29240557/impact-of-motion-compensation-and-partial-volume-correction-for-18f-naf-pet-ct-imaging-of-coronary-plaque
#9
J Cal-González, C Tsoumpas, M L Lassen, S Rasul, L Koller, M Hacker, K Schäfers, T Beyer
Recent studies have suggested that 18F-NaF-PET enables visualization and quantification of plaque micro-calcification in the coronary tree. However, PET imaging of plaque calcification in the coronary arteries is challenging because of the respiratory and cardiac motion as well as partial volume effects. The objective of this work is to implement an image reconstruction framework, which incorporates compensation for respiratory as well as cardiac motion (MoCo) and partial volume correction (PVC), for cardiac 18F-NaF PET imaging in PET/CT...
December 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29240464/analysis-of-agreement-of-retinal-layer-thickness-measures-derived-from-the-segmentation-of-horizontal-and-vertical-spectralis-oct-macular-scans
#10
Natalia Gonzalez Caldito, Bhavna Antony, Yufan He, Andrew Lang, James Nguyen, Alissa Rothman, Esther Ogbuokiri, Ama Avornu, Laura Balcer, Elliot Frohman, Teresa C Frohman, Pavan Bhargava, Jerry Prince, Peter A Calabresi, Shiv Saidha
PURPOSE: Optical coherence tomography (OCT) is a reliable method used to quantify discrete layers of the retina. Spectralis OCT is a device used for this purpose. Spectralis OCT macular scan imaging acquisition can be obtained on either the horizontal or vertical plane. The vertical protocol has been proposed as favorable, due to postulated reduction in confound of Henle's fibers on segmentation-derived metrics. Yet, agreement of the segmentation measures of horizontal and vertical macular scans remains unexplored...
December 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29240460/two-adolescent-cases-of-psychotropic-related-nonaffective-oniomania
#11
Ahmed Naguy, Waleed Abdelhakim, Ali Al-Tajali
Oniomania, or compulsive buying disorder (CBD), an acquisitive impulse dyscontrol disorder, is not officially acknowledged in current classificatory systems, but remains a valid diagnostic construct on clinical grounds. In this study, authors report on two interesting adolescent cases of "secondary" oniomania related to use of psychotropics. This is followed by discussion of putative pharmacodynamic mechanisms, working differential, and an overview of current literature on CBD.
December 14, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29240287/comparative-study-of-femtosecond-laser-assisted-cataract-surgery-and-conventional-phacoemulsification-in-vitrectomised-eyes
#12
Ellen F Wang, Andrew Worsley, Philip J Polkinghorne
IMPORTANCE: To compare the safety and outcomes of femtosecond laser assisted cataract surgery and conventional phacoemulsification in post-vitrectomy eyes. BACKGROUND: To compare visual outcomes and adverse outcomes of femtosecond laser assisted cataract surgery and conventional phacoemulsification in vitrectomised eyes. DESIGN: Single surgeon, retrospective study set in a private clinic in Auckland, New Zealand. Patients selected in a chronological manner, without masking or randomisation...
December 14, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29240255/extracting-unresolved-coupling-constants-from-complex-multiplets-by-a-real-time-j-upscaled-serf-experiment
#13
Kathrin Buchberger, Martin Walenta, Klaus Zangger
The measurement of small homonuclear coupling constants is often prevented by either their small size and/or overlap with other signal splittings. Here we present a real-time method to extract such couplings without interference from other splittings, with a resolution that is beyond conventional NMR spectra. In this real-time J-upscaled SERF experiment, homonuclear coupling is removed by slice-selective pure shift NMR, while scalar coupling to only one selected signal is reintroduced by selective refocusing (SERF)...
December 14, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29240254/nf-%C3%AE%C2%BAb-regulated-mir-155-via-repression-of-qki-contributes-to-the-acquisition-of-csc-like-phenotype-during-the-neoplastic-transformation-of-hepatic-cells-induced-by-arsenite
#14
Chao Chen, Fei Luo, Qianlei Yang, Dapeng Wang, Ping Yang, Junchao Xue, Xiangyu Dai, Xinlu Liu, Hui Xu, Jiachun Lu, Aihua Zhang, Qizhan Liu
Chronic exposure to arsenite can cause various human tumors. For the initiation and recurrence of human liver cancer, the acquisition of CSC-like properties is essential. In various cancers, microRNAs (miRNAs) act as regulators in induction of CSC-like properties. Liver cancers over-express miR-155, but the mechanism relating miR-155 and arsenite-induced liver cancer is unknown. Here, we show that long-term exposure of L-02 cells to arsenite increases miR-155 levels by activation of NF-κB and leads to the acquisition of CSC-like properties...
December 14, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29240131/exposure-fusion-based-dot-grid-image-acquisition-and-recognition-for-sheet-metal-strain-analysis
#15
Bao-Quan Shi, Li-Kun Zhang, Chen-Song Yao, Shu-Xing Du, JunJie Ye
Dot-grid images are usually captured for grid strain analysis during sheet metal forming. Due to the strong reflective characteristic of the metallic surfaces, the recorded dot-grid images often have poor quality, low positioning accuracy, and low recognition rate. Therefore, an exposure-fusion-based dot-grid image acquisition and recognition approach is proposed. First, multiple dot-grid images are captured at different exposure levels. Subsequently, the recorded multi-exposure dot-grid images are fused into a new high-quality dot-grid image based on exposure fusion technology...
December 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29239887/incidence-of-sexually-transmitted-infections-before-and-after-pre-exposure-prophylaxis-for-hiv-a-cohort-study
#16
Vinh-Kim Nguyen, Zoë R Greenwald, Helen Trottier, Martha Cadieux, Alexandre Goyette, Mariève Beauchemin, Louise Charest, Danièle Longpré, Stéphane Lavoie, Hermione Gbego Tossa, Réjean Thomas
OBJECTIVE: Use of Pre-Exposure Prophylaxis (PrEP) for HIV raises concerns about sexually transmitted infection (STI) incidence due to decreased condom use among men who have sex with men (MSM). This study examines whether PrEP is associated with STIs in the 12-months following PrEP prescription relative to the 12-months prior to PrEP and if STI rates are higher among PrEP users relative to individuals receiving Post-Exposure Prophylaxis (PEP). DESIGN: Retrospective cohort study including PrEP users with >12 months of follow-up before PrEP prescription and individuals receiving PEP from 2010-2015 at Clinique l'Actuel (Montréal, Canada)...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29239563/a-geographical-information-system-for-the-management-of-the-aquaculture-data-in-the-adriatic-sea-the-strengthening-of-centres-for-aquaculture-production-and-safety-surveillance-in-the-adriatic-countries-experience-present-capabilities-tools-and-functions
#17
Susanna Tora, Silvio Sacchini, Eddy Listeš, Tanja Bogdanović, Alessio Di Lorenzo, Muhamed Smajlović, Ahmed Smajlović, Jelena V Filipović, Vildana Tahirović, Danijela Šuković, Bojan Beljkas, Ardian Xinxo, Renis Maçi, Patrizia Colangeli, Federica Di Giacinto, Annamaria Conte
The European Commission (EC) regulation no. 854/2004 requires a systematic monitoring of chemical and microbiological contaminants in live bivalve molluscs, live echinoderms, live tunicates and live marine gastropods for human consumption through surveillance plans to be implemented in all European Union (EU) countries.A consortium of five Adriatic countries was set up in the framework of the Instrument of Pre-accession Assistance Adriatic Cross-border Cooperation Programme (IPA Adriatic CBC) 2007- 2013 with the aim of collecting data and distribute information on harvesting and production in mollusc areas...
November 8, 2017: Geospatial Health
https://www.readbyqxmd.com/read/29239261/white-matter-tract-integrity-an-indicator-of-axonal-pathology-after-mild-traumatic-brain-injury
#18
Sohae Chung, Els Fieremans, Xiuyuan Wang, Nuri E Kucukboyaci, Charles J Morton, James S Babb, Prin Amorapanth, Farng-Yang Foo, Dmitry S Novikov, Steven R Flanagan, Joseph F Rath, Yvonne W Lui
We seek to elucidate the underlying pathophysiology of injury sustained after mild traumatic brain injury (MTBI) using multi-shell diffusion MRI, deriving compartment-specific WM tract integrity (WMTI) metrics. WMTI allows a more biophysical interpretation of WM changes by describing microstructural characteristics in both intra- and extra-axonal environments. Thirty-two patients with MTBI within 30 days of injury and twenty-one age- and sex-matched controls were imaged on a 3T MR scanner. Multi-shell diffusion acquisition was performed with 5 b-values (250 - 2500 s/mm<sup>2</sup>) along 6 - 60 diffusion encoding directions...
December 14, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29239227/micro-costing-analysis-demonstrates-comparable-costs-for-lithovue%C3%A2-compared-to-reusable-flexible-fiberoptic-ureteroscopes
#19
Kazumi Taguchi, Manint Usawachintachit, David T Tzou, Benjamin Sherer, Ian Metzler, Dylan Isaacson, Marshall Stoller, Thomas Chi
INTRODUCTION: Reusable ureteroscope durability and need for repair are significant sources of expense and inefficiency for patients and urologists. Utilization of LithoVue™, a disposable flexible digital ureteroscope, may address some of these concerns. To identify its economic impact on clinical care, we performed a micro-cost comparison between flexible reusable fiberoptic ureteroscopes (URF-P6™) and LithoVue™. PATIENTS AND METHODS: For this prospective, single-center micro-costing study, all consecutive ureteroscopies performed during one week each in July and August 2016 utilized either URF-P6™ or LithoVue™ ureteroscopes respectively...
December 14, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29238109/present-and-future-roles-of-fdg-pet-ct-imaging-in-the-management-of-gastrointestinal-cancer-an-update
#20
REVIEW
Kazuhiro Kitajima, Masatoyo Nakajo, Hayato Kaida, Ryogo Minamimoto, Kenji Hirata, Masakatsu Tsurusaki, Hiroshi Doi, Yoshiko Ueno, Keitaro Sofue, Yukihisa Tamaki, Koichiro Yamakado
Positron emission tomography/computed tomography (PET/CT) integrated with 2-[18F]fluoro-2-deoxy-D-glucose (FDG) is a useful tool for acquisition of both glucose metabolism and anatomic imaging data, as only a single device and one diagnostic session is required, thus opening a new field in clinical oncologic imaging. FDG-PET/CT has been successfully used for initial staging, restaging, assessment of early treatment response, evaluation of metastatic disease response, and prognostication of intestinal cancer as well as various malignant tumors...
November 2017: Nagoya Journal of Medical Science
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