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https://www.readbyqxmd.com/read/28937263/imaging-features-of-breast%C3%A2-cancers-on-digital%C3%A2-breast%C3%A2-tomosynthesis%C3%A2-according-to%C3%A2-molecular%C3%A2-subtype-association-with%C3%A2-breast%C3%A2-cancer%C3%A2-detection
#1
Su Hyun Lee, Jung Min Chang, Sung Ui Shin, A Jung Chu, Ann Yi, Nariya Cho, Woo Kyung Moon
OBJECTIVE: To evaluate imaging features of breast cancers on digital breast tomosynthesis (DBT) according to molecular subtype and to determine whether the molecular subtype affects breast cancer detection on DBT. METHODS: This was an institutional review board-approved study with a waiver of informed consent. DBT findings of 288 invasive breast cancers were reviewed according to BI-RADS lexicon. Detectability of breast cancer was quantified by the number of readers (0-3) who correctly detected the cancer in an independent blinded review...
September 13, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28936186/assessing-the-formation-of-experience-based-gender-expectations-in-an-implicit-learning-scenario
#2
Anton Öttl, Dawn M Behne
The present study investigates the formation of new word-referent associations in an implicit learning scenario, using a gender-coded artificial language with spoken words and visual referents. Previous research has shown that when participants are explicitly instructed about the gender-coding system underlying an artificial lexicon, they monitor the frequency of exposure to male vs. female referents within this lexicon, and subsequently use this probabilistic information to predict the gender of an upcoming referent...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28935617/the-adverse-drug-reactions-from-patient-reports-in-social-media-project-five-major-challenges-to-overcome-to-operationalize-analysis-and-efficiently-support-pharmacovigilance-process
#3
Cedric Bousquet, Badisse Dahamna, Sylvie Guillemin-Lanne, Stefan J Darmoni, Carole Faviez, Charles Huot, Sandrine Katsahian, Vincent Leroux, Suzanne Pereira, Christophe Richard, Stéphane Schück, Julien Souvignet, Agnès Lillo-Le Louët, Nathalie Texier
BACKGROUND: Adverse drug reactions (ADRs) are an important cause of morbidity and mortality. Classical Pharmacovigilance process is limited by underreporting which justifies the current interest in new knowledge sources such as social media. The Adverse Drug Reactions from Patient Reports in Social Media (ADR-PRISM) project aims to extract ADRs reported by patients in these media. We identified 5 major challenges to overcome to operationalize the analysis of patient posts: (1) variable quality of information on social media, (2) guarantee of data privacy, (3) response to pharmacovigilance expert expectations, (4) identification of relevant information within Web pages, and (5) robust and evolutive architecture...
September 21, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28915783/prediction-of-agreement-and-phonetic-overlap-shape-sublexical-identification
#4
Andrea E Martin, Philip J Monahan, Arthur G Samuel
The mapping between the physical speech signal and our internal representations is rarely straightforward. When faced with uncertainty, higher-order information is used to parse the signal and because of this, the lexicon and some aspects of sentential context have been shown to modulate the identification of ambiguous phonetic segments. Here, using a phoneme identification task (i.e., participants judged whether they heard [o] or [a] at the end of an adjective in a noun-adjective sequence), we asked whether grammatical gender cues influence phonetic identification and if this influence is shaped by the phonetic properties of the agreeing elements...
September 2017: Language and Speech
https://www.readbyqxmd.com/read/28912577/classifying-the-evolutionary-and-ecological-features-of-neoplasms
#5
REVIEW
Carlo C Maley, Athena Aktipis, Trevor A Graham, Andrea Sottoriva, Amy M Boddy, Michalina Janiszewska, Ariosto S Silva, Marco Gerlinger, Yinyin Yuan, Kenneth J Pienta, Karen S Anderson, Robert Gatenby, Charles Swanton, David Posada, Chung-I Wu, Joshua D Schiffman, E Shelley Hwang, Kornelia Polyak, Alexander R A Anderson, Joel S Brown, Mel Greaves, Darryl Shibata
Neoplasms change over time through a process of cell-level evolution, driven by genetic and epigenetic alterations. However, the ecology of the microenvironment of a neoplastic cell determines which changes provide adaptive benefits. There is widespread recognition of the importance of these evolutionary and ecological processes in cancer, but to date, no system has been proposed for drawing clinically relevant distinctions between how different tumours are evolving. On the basis of a consensus conference of experts in the fields of cancer evolution and cancer ecology, we propose a framework for classifying tumours that is based on four relevant components...
September 15, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28899847/enhancing-seasonal-influenza-surveillance-topic-analysis-of-widely-used-medicinal-drugs-using-twitter-data
#6
Ireneus Kagashe, Zhijun Yan, Imran Suheryani
BACKGROUND: Uptake of medicinal drugs (preventive or treatment) is among the approaches used to control disease outbreaks, and therefore, it is of vital importance to be aware of the counts or frequencies of most commonly used drugs and trending topics about these drugs from consumers for successful implementation of control measures. Traditional survey methods would have accomplished this study, but they are too costly in terms of resources needed, and they are subject to social desirability bias for topics discovery...
September 12, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28899222/effects-of-sotagliflozin-added-to-insulin-in-patients-with-type-1-diabetes
#7
Satish K Garg, Robert R Henry, Phillip Banks, John B Buse, Melanie J Davies, Gregory R Fulcher, Paolo Pozzilli, Diane Gesty-Palmer, Pablo Lapuerta, Rafael Simó, Thomas Danne, Darren K McGuire, Jake A Kushner, Anne Peters, Paul Strumph
Background In most patients with type 1 diabetes, adequate glycemic control is not achieved with insulin therapy alone. We evaluated the safety and efficacy of sotagliflozin, an oral inhibitor of sodium-glucose cotransporters 1 and 2, in combination with insulin treatment in patients with type 1 diabetes. Methods In this phase 3, double-blind trial, which was conducted at 133 centers worldwide, we randomly assigned 1402 patients with type 1 diabetes who were receiving treatment with any insulin therapy (pump or injections) to receive sotagliflozin (400 mg per day) or placebo for 24 weeks...
September 13, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28885890/qualitative-radiogenomics-association-between-oncotype-dx-test-recurrence-score-and-bi-rads-mammographic-and-breast-mr-imaging-features
#8
Genevieve A Woodard, Kimberly M Ray, Bonnie N Joe, Elissa R Price
Purpose To evaluate the association between Breast Imaging Reporting and Data System (BI-RADS) mammographic and magnetic resonance (MR) imaging features and breast cancer recurrence risk in patients with estrogen receptor-positive breast cancer who underwent the Oncotype DX assay. Materials and Methods In this institutional review board-approved and HIPAA-compliant protocol, 408 patients diagnosed with invasive breast cancer between 2004 and 2013 who underwent the Oncotype DX assay were identified. Mammographic and MR imaging features were retrospectively collected according to the BI-RADS lexicon...
September 8, 2017: Radiology
https://www.readbyqxmd.com/read/28880767/cross-language-neighborhood-effects-in-learners-indicative-of-an-integrated-lexicon
#9
Gabriela Meade, Katherine J Midgley, Ton Dijkstra, Phillip J Holcomb
This study examined how acquisition of novel words from an unknown language (L2) is influenced by their orthographic similarity with existing native language (L1) words in beginning adult learners. Participants were tested in a two-alternative forced-choice recognition task and a typing production task as they learned to associate 80 L2 (pseudo)words with pictures depicting their meanings. There was no effect of L1 orthographic neighborhood density on accuracy in the two-alternative forced-choice task, but typing accuracy was higher for L2 words with many L1 neighbors in the earliest stages of learning...
September 7, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/28880180/conceptvector-text-visual-analytics-via-interactive-lexicon-building-using-word-embedding
#10
Deokgun Park, Seungyeon Kim, Jurim Lee, Jaegul Choo, Nicholas Diakopoulos, Niklas Elmqvist
Central to many text analysis methods is the notion of a concept: a set of semantically related keywords characterizing a specific object, phenomenon, or theme. Advances in word embedding allow building a concept from a small set of seed terms. However, naive application of such techniques may result in false positive errors because of the polysemy of natural language. To mitigate this problem, we present a visual analytics system called ConceptVector that guides a user in building such concepts and then using them to analyze documents...
August 31, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28870060/sonographic-features-that-can-be-used-to-differentiate-between-small-triple-negative-breast-cancer-and-fibroadenoma
#11
Ga Young Yoon, Joo Hee Cha, Hak Hee Kim, Hee Jung Shin, Eun Young Chae, Woo Jung Choi
Purpose: Our study investigated whether any sonographic findings could be useful for differentiating between small triple-negative breast cancer (TNBC) and fibroadenoma. Methods: This retrospective study was approved by our Institutional Review Board, which waived the requirement for patient consent. From January 2009 to December 2010, the sonographic features of 181 pathologically proven TNBC tumors and 172 fibroadenomas measuring less than or equal to 2 cm in the longest dimension were reviewed and analyzed according to the fifth edition of the Breast Imaging Reporting and Data System (BI-RADS) lexicon...
August 4, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28869840/the-cognate-facilitation-effect-in-bilingual-lexical-decision-is-influenced-by-stimulus-list-composition
#12
Eva D Poort, Jennifer M Rodd
Cognates share their form and meaning across languages: "winter" in English means the same as "winter" in Dutch. Research has shown that bilinguals process cognates more quickly than words that exist in one language only (e.g. "ant" in English). This finding is taken as strong evidence for the claim that bilinguals have one integrated lexicon and that lexical access is language non-selective. Two English lexical decision experiments with Dutch-English bilinguals investigated whether the cognate facilitation effect is influenced by stimulus list composition...
September 1, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28865039/the-roles-of-relative-linguistic-proficiency-and-modality-switching-in-language-switch-cost-evidence-from-chinese-visual-unimodal-and-bimodal-bilinguals
#13
Aitao Lu, Lu Wang, Yuyang Guo, Jiahong Zeng, Dongping Zheng, Xiaolu Wang, Yulan Shao, Ruiming Wang
The current study investigated the mechanism of language switching in unbalanced visual unimodal bilinguals as well as balanced and unbalanced bimodal bilinguals during a picture naming task. All three groups exhibited significant switch costs across two languages, with symmetrical switch cost in balanced bimodal bilinguals and asymmetrical switch cost in unbalanced unimodal bilinguals and bimodal bilinguals. Moreover, the relative proficiency of the two languages but not their absolute proficiency had an effect on language switch cost...
September 1, 2017: Journal of Psycholinguistic Research
https://www.readbyqxmd.com/read/28861022/inhibitory-control-in-speech-comprehension-among-dai-han-bilingual-children
#14
Yun Tao, Zhi Liu, Tobias Tempel, Rui Chen, Xie Ma, Xiaoxi Wang, Yan Liu, Yongxia Qu
We aimed to investigate differences in inhibitory control ability between proficient and non-proficient Dai-Han bilinguals. Two experiments used a combined stimulus-stimulus and stimulus-response compatibility paradigm for this purpose. Participants were Dai-Han bilingual primary-school students selected from a Dai-speaking town in Yunnan province, China. In Dai language interference condition, participants were asked to complete a picture category task. Results showed that the effect of attentional control for non-proficient bilinguals (NPBs) was significantly greater than that for proficient bilinguals (PBs), while the effect of response inhibition was not...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28854861/beyond-the-clinic-eluding-a-medical-diagnosis-of-anorexia-through-narrative
#15
Merav Shohet
The persistence and recurrence of anorexia nervosa poses a clinical challenge, and provides support for critiques of oppressive and injurious facets of society inscribed on women's bodies. This essay illustrates how a phenomenological, linguistic anthropological approach fruitfully traverses clinical and cultural perspectives by directing attention beyond the embodied experience of patients diagnosed with anorexia nervosa to those who are not clinically diagnosed. Extending a model of illness and recovery as entailing sufferers' emplotting of past, present, and imagined future selves, I argue that women's accounts of their experiences do not simply reflect lived reality, but actually propel health-relevant states of being by enlivening and creating these realities in the process of their telling...
January 1, 2017: Transcultural Psychiatry
https://www.readbyqxmd.com/read/28834447/revisiting-nonmass-enhancement-in-breast-mri-analysis-of-outcomes-and-follow-up-using-the-updated-bi-rads-atlas
#16
Sona A Chikarmane, Aya Y Michaels, Catherine S Giess
OBJECTIVE: The purpose of this study is to assess the frequency of reclassification of nonmass enhancement (NME) as background parenchymal enhancement (BPE) and to determine positive predictive values (PPVs) of NME descriptors using the revised BI-RADS atlas. MATERIALS AND METHODS: A retrospective review of our institution's MRI database from January 1, 2009, through March 30, 2012, identified 6220 contrast-enhanced breast MRI examinations. All findings prospectively assessed as NME and rated as BI-RADS categories 3, 4, and 5 (n = 386) were rereviewed in consensus by two radiologists who were blinded to pathologic findings with the fifth edition of the BI-RADS lexicon...
August 23, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28834327/reading-comprehension-of-ambiguous-sentences-by-school-age-children-with-autism-spectrum-disorder
#17
Meghan M Davidson, Susan Ellis Weismer
Weak central coherence (processing details over gist), poor oral language abilities, poor suppression, semantic interference, and poor comprehension monitoring have all been implicated to affect reading comprehension in individuals with autism spectrum disorder (ASD). This study viewed the contributions of different supporting skills as a collective set of skills necessary for context integration-a multi-component view-to examine individual differences in reading comprehension in school-age children (8-14 years) with ASD (n = 23) and typically developing control peers (n = 23)...
August 22, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28829530/the-social-construction-of-disasters-in-the-united-states-a-historical-and-cultural-phenomenon
#18
Tonya T Neaves, T Aaron Wachhaus, Grace A Royer
INTRODUCTION: Societal risks from hazards are continually increasing. Each year, disasters cause thousands of deaths and cost billions of dollars. In the first half of 2011, the United States endured countless disasters-winter snowstorms in the Midwest and Northeast; severe tornadic weather in the Mississippi, Alabama, and Missouri; flash flooding in Nashville; flooding along the Mississippi River; an earthquake on the East Coast, wildfires in Texas, and Hurricane Irene. Fundamental disaster planning is regarded as an interdisciplinary approach to develop strategies and instituting policies concerned with phases of emergency management; as such, its needs are predicated on the identification of hazards and assessment of risks...
May 2017: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/28816987/analysis-of-background-parenchymal-echogenicity-on-breast-ultrasound-correlation-with-mammographic-breast-density-and-background-parenchymal-enhancement-on-magnetic-resonance-imaging
#19
Kyung Hee Ko, Hae Kyoung Jung, Inwha Kim
The purpose of this study was to analyze the background parenchymal echotexture (BP echo) on breast ultrasound in detail and to evaluate the relation BP echo with menopausal status. In addition, we correlated BP echo with mammographic breast density (MGD) and background parenchymal enhancement (BPE) on magnetic resonance imaging (MRI).The institutional review board of our hospital approved this retrospective study, and the requirement of informed consent was waived. We studied 138 women (mean age 51.6 years, range from 26 to 79 years) with newly diagnosed invasive breast cancer, who had performed preoperative mammography, ultrasound, and MR from June 2013 to June 2015...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28796549/association-of-brca-mutation-types-imaging-features-and-pathologic-findings-in-patients-with-breast-cancer-with-brca1-and-brca2-mutations
#20
Su Min Ha, Eun Young Chae, Joo Hee Cha, Hak Hee Kim, Hee Jung Shin, Woo Jung Choi
OBJECTIVE: The purpose of this study is to retrospectively evaluate the relationships between the BRCA mutation types, imaging features, and pathologic findings of breast cancers in BRCA1 and BRCA2 mutation carriers. MATERIALS AND METHODS: We identified patients with breast cancer with BRCA gene mutations from January 2000 to December 2014. After excluding patients who underwent lesion excision before MRI, 99 BRCA1 and 103 BRCA2 lesions in 187 women (mean age, 39...
August 10, 2017: AJR. American Journal of Roentgenology
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