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hepatocelular carcinoma

Felipe de Lucena Moreira Lopes, Fabricio Ferreira Coelho, Jaime Arthur Pirolla Kruger, Gilton Marques Fonseca, Raphael Leonardo Cunha de Araujo, Vagner Birk Jeismann, Paulo Herman
BACKGROUND: Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer and its incidence is increasing around the world in the last decades, making it the third cause of death by cancer in the world. Hepatic resection is one of the most effective treatments for HCC with five-year survival rates from 50-70%, especially for patients with a single nodule and preserved liver function. Some studies have shown a worse prognosis for HCC patients whose etiology is viral...
April 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
Kristel Mils, Laura Lladó, Emilio Ramos, Juan Domínguez, Carme Baliellas
No abstract text is available yet for this article.
July 16, 2016: Cirugía Española
S Rodriguez, G Balbinotto, A Brandão
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
M Romero, R Marrugo, P A Alfonso Quiñones, G Acero
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Tian-Hua Liu, Kun Guo, Ri-Qiang Liu, Shu Zhang, Zhuo-Hui Huang, Yin-Kun Liu
OBJECTIVE: To investigate whether the expression of serum soluble neural cell adhesion molecule (sNCAM) is associated with hepatic encephalopathy (HE) in hepatocelular carcinoma (HCC) patients. MATERIALS AND METHODS: The Oncomine Cancer Microarray database was used to determine the clinical relevance of NCAM expression in different kinds of human cancers. Sera from 75 HCC cases enrolled in this study were assessed for expression of sNCAM by enzyme linked immunosorbent assay (ELISA)...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
María Sarai González Huezo, Juan Francisco Sánchez Ávila
INTRODUCTION: There has been an increase in the incidence of hepatocellular carcinoma (HCC) worldwide and information on this disease is limited in Mexico. AIMS: To analyze the available evidence on the diagnosis and treatment of HCC in the Mexican population. MATERIAL AND METHODS: The Mexican Association of Hepatology organized a meeting that 24 medical specialists interested in HCC attended. An electronic database search was carried out to identify documents published from 2000 with the keywords «Hepatocellular carcinoma» and «Mexico», «epidemiology», «diagnosis», and «treatment»...
October 2014: Revista de Gastroenterología de México
Xianhan Jiang, Weide Zhong, Hai Huang, Huichan He, Funeng Jiang, Yanru Chen, Fei Yue, Jing Zou, Xun Li, Yongzhong He, Pan You, Weiqiang Yang, Yiming Lai, Fen Wang, Leyuan Liu
MAP1S (originally named C19ORF5) is a widely distributed homolog of neuronal-specific MAP1A and MAP1B, and bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation. Mitochondrion-associated protein LRPPRC functions as an inhibitor for autophagy initiation to protect mitochondria from autophagy degradation. MAP1S and LRPPRC interact with each other and may collaboratively regulate autophagy although the underlying mechanism is yet unknown. Previously, we have reported that LRPPRC levels serve as a prognosis marker of patients with prostate adenocarcinomas (PCA), and that patients with high LRPPRC levels survive a shorter period after surgery than those with low levels of LRPPRC...
October 2015: Molecular Carcinogenesis
Kai-Ge Liu, Gang-Zhu Xu, Yang Yao, Wei Wu, Ya-Jun Li, Ting-Ting Ren, Guang-Hua Xu, Lin Ye
AIM: To investigate the expression and clinical significance of CEACAM1 and HBx in HBV related hepatocellular carcinoma. METHODS: The expression of CEACAM1 and HBx in 81 HBV related hepatocellular carcinoma were detected by immunohistochemistry, and the relationship with clinicopathological features was analyzed. The expression of CEACAM1 in the human normal hepatocyte cell line QZG, HepG2 and HepG2-X were detected by Western blot. RESULTS: The positive rate of CEACAM1 and HBx in 81 HBV related hepatocellular carcinoma tissues were 71...
April 2012: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
João Barbosa, Filipe Calinas
Hepatitis B (HBV) and hepatitis C (HCV) are the most common causes of chronic liver disease. Due to shared routes of transmission, co-infection with HBV and HCV is not uncommon. Higher rates of cirrhosis and hepatocelular carcinoma have been demonstrated in HBV/HCV co-infected patients. No treatment standard has been established for HBV/HCV co-infected patients. Treatment decisions must be made based upon identification of the dominant virus, usually HCV, thus patients should receive pegylated interferon alpha with ribavirin as for HCV monoinfection...
January 2011: Acta Médica Portuguesa
Małgorzata Znyk
HCV infection may result in serious health consequences such as chronic hepatitis C, liver cirrhosis and hepatocelulare carcinoma. In lodzkie voivodeship, the data from 2003- 2008 demonstrate a slight upward trend. In 2003 there were 280 registered cases (incidence 10.76 per 100 000). In the year 2008, a number of cases (199) and an incidence (7.8 per 100 000) of hepatitis C was lower than in prodecting years. Hepatitis C cases aged 15-19 constituted the most predominant group. As observed previously the incidence in the urban areas was two times higher than the incidence in rural areas and the incidence in men was twice higher than in women...
2010: Przegla̧d Epidemiologiczny
Ting Zhang, Ying-ze Zhao, Jin-yong Luo, Xiao-juan Lu, Wei Wen, Tao Feng
OBJECTIVE: To construct a retroviral vector carrying HBX gene and investigate its expression in LO2 human hepatocytes. METHODS: HBX gene was amplified by PCR and subcloned into the retroviral vector pSEB-Flag to construct a retroviral plasmid (pSEB-Flag-HBX) expressing HBX. The HBX gene insert was confirmed by restriction enzyme digestion, PCR and DNA sequencing. The recombinant retroviruses carrying HBX gene were generated in 293T cells co-transfected with pSEB-Flag-HBX and the packaging plasmids pAmpho, and used to infect LO2 human hepatocyte...
July 2010: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Zeljko Grabarević, Marijana Corić, Sven Seiwerth, Petar Dzaja, Branka Artuković, Andrea Gudan Kurilj, Ana Beck, Marko Hohsteter, Ivan-Conrado Sostarić-Zuckermann, Luka Brcić, Irena Hrstić
Concerning the important differences in the ethiopathology of hepatocelular carcinomas (HCC) in humans and dogs, our work describes the expression of epidermal growth factor receptor (EGFr), cytokeratine 19 (CK19), vascular endothelial growth factor (VEGF) and transforming growth factor beta receptor (TGFbeta-r) in tumors arising in both species. Investigation included 25 cases of human and 8 cases of dog tumors. All human cases were noted in cirrhotic livers, while in dogs the tissue adjacent to tumor was not changed...
September 2009: Collegium Antropologicum
Ricardo Ulises Macías-Rodríguez, Aldo Torre
Cryptogenic cirrhosis represents the third cause of cirrhosis in Mexico and comprises the clinical spectrum of NAFLD. Insulin resistance is the main factor in NASH development, as well as genetic and environmental factors. Derangement in insulin signaling pathways, either pre-receptor or post-receptor, causes insulin resistance (IR). The post-receptor dysfunction represents the primary cause of IR and links with metabolic syndrome, mainly diabetes and obesity. Prevailing metabolic moment will establish the IR status...
March 2009: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
B H Ferraz-Neto, M P V C Zurstrassen, R Hidalgo, S P Meira-Filho, M B Rezende, A T Paes, R C Afonso
Since July 2006, the liver graft allocation has been changed from the waiting time to the Model for End-stage Liver Disease (MELD), prioritizing the sickest patients, who have a higher risk of dying on the waiting list, and sometimes in such poor clinical condition that it compromises transplantation outcomes. The aim of this study was to analyze the impact of a MELD score > or = 30 on 30-day survival after liver transplantation (OLT). We prospectively collected the data on 178 liver transplants on 163 patients performed from March 2003 to August 2007...
April 2008: Transplantation Proceedings
Carlos Gilberto Canelo Aybar, José Luís Cuadra Urteaga, F Fujii, Franco Romaní Romaní, Fernando Alonso Atencia Matute, Rogger Oscar Verona Rubio
The tumour pulmonary micro-embolism is a rare condition characterized by the occlusion of pulmonary small arteries, arteriolas, and alveolar capillaries septales, accompanied of trombosis. Occasionally the development of pulmonary hypertension is the first manifestation of an occult neoplasia, in series of autopsies, an incidence from 3 to 26% has been reported in solid tumors, being clinical evident in 8%. Few cases have documented the development of this condition in patients with carcinoma hepatocelular, we report the case of a 16-year-old male who comes to the emergency with signs of cardiac insufficiency and cor pulmonare whose anatomopatological study confirmed a tumour massive microembolic compromise at pulmonary level and hepatocarcinoma...
January 2008: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
T Skalicky, V Treska, V Liska, A Sutnar, J Molacek, H Mirka, J Ferda, K Ohlidalova
As opposed to malignant secondary tumors, metastases of the colorectal carcinoma are benign tumors of the liver that are quite rare in the Czech Republic. From the 55 patients operated on since 2000 at our department for benign liver tumors, the most frequent are haemangiomas, focal nodular hyperplasia (FNH) and hepatocelular adenoma. Only 7.3% of them form a different histological type of a tumor than this most frequently occurring trio of tumors. The authors describe three cases of rather rare liver tumors with benign behavior that have the potential of becoming malignant...
2007: Bratislavské Lekárske Listy
Jiunn-Jye Chuu, Jacqueline Ming Liu, Mei-Hua Tsou, Chen-Lung Huang, Ching-Ping Chen, Hsin-Sheng Wang, Chiung-Tong Chen
Cancer has been the leading cause of death in Taiwan over the past two decades and liver cancer is the leading cause of all cancer deaths in Taiwan with a trend of increase in incidence. Therapeutic options and efficacy for liver cancer have been limited and the 5-year survival rate is less than 7% in the Unite States. The study was conducted to establish a histoculture system of human hepatocellular carcinomas (HCC) for biological and pharmacological studies and to determine the efficacy of anticancer drugs with the established HCC histocultures...
March 2007: Journal of Biomedical Science
Guillermo Valladares Alvarez
The Hepatitis C virus has emerged over the last two decades as the cause of the second greatest viral infection epidemic after the human immunodeficiency virus (HIV). A significant characteristic of the infection with the Hepatitis C virus is the variable course of its natural history. About 80% of the people who acquire this agent develop a chronic infection, with varying degree of liver damage, including cirrhosis and even hepatocelular carcinoma. However, only a minority progresses towards more severe forms...
April 2003: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
(no author information available yet)
A bioassay of p-cresidine for possible carcinogenicity was conducted using Fischer 344 rats and B6C3F1 mice. p-Cresidine was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. The dietary concentrations used in the chronic bioassay for low and high dose rats were 0.5 and 1.0 percent, respectively. The time-weighted average concentrations fed to low dose male, low dose female, high dose male and high dose female mice were 0.22, 0.22. 0.46, and 0...
1979: National Cancer Institute Carcinogenesis Technical Report Series
W X Qin, F Wan, F Y Sun, P P Zhang, L W Han, Y Huang, H Q Jiang, X T Zhao, M He, Y Ye, W M Cong, M C Wu, L S Zhang, N W Yang, J R Gu
Using a combination of hybridization of PAC to a cDNA library and RACE technique, we isolated a novel cDNA, designated as C17orf25 (Chromosome 17 open reading frame 25, previously named it HC71A), from the deletion region on chromosome 17p13.3. The cDNA encodes a protein of 313 amino acids with a calculated molecular mass of 34.8 kDa. C17orf25 is divided into 10 exons and 9 introns, spanning 23 kb of genomic DNA. Northern blot analysis showed that the mRNA expression of C17orf25 was decreased in hepatocellular carcinoma samples as compared to adjacent noncancerous liver tissues from the same patients...
September 2001: Cell Research
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