Jeyson Césary Lopes, Françoise Vasconcelos Botelho, Marcelo José Barbosa Silva, Suélen Fernandes Silva, Lorena Polloni, Pedro Henrique Alves Machado, Tiago Rodrigues de Souza, Luiz Ricardo Goulart, Priscila Pereira Silva Caldeira, Elene Cristina Pereira Maia, Sandra Morelli, Robson J de Oliveira-Júnior
Recently, a high number of copper derivatives has been evaluated as DNA-targeting metallodrugs, due to the lower toxicity and its potential to cleave DNA. Several strategies have been testing to develop metal compounds effective against tumour cells. In this work, the ternary copper (doxycycline)-(1,10-phenanthroline) complex [Cu(dox)(phen)]2+ was especially designed as an antitumoral drug, previously showing high cytotoxicity and DNA cleavage activity. We aimed to further investigate the in vitro cytotoxic activity in both tumoral and non-tumoral cells, in vitro genotoxic potential, and in vivo antitumor activity using BALB/C mouse injected with sarcoma S180 and Ehrlich cell lines...
December 17, 2020: Biochemical and Biophysical Research Communications