keyword
https://read.qxmd.com/read/33380281/antitumour-activity-of-annona-muricata-l-leaf-methanol-extracts-against-ehrlich-ascites-carcinoma-and-dalton-s-lymphoma-ascites-mediated-tumours-in-swiss-albino-mice
#21
JOURNAL ARTICLE
Aditi Venkatesh Naik, Shanti N Dessai, Krishnan Sellappan
The use of plants as a source of sedative or treatment for cancer is reasonably widespread worldwide. Annona muricata Linn exhibits a vast array of medicinal and ethno-pharmaceutical benefits, attributed by different plant parts. The activity of this plant is regarded to the bio-production of secondary metabolites like alkaloids, phenols, flavonoids, and most unique group of compounds, namely, annonaceous acetogenins. Whilst this plant is gaining popularity as an anticancer treating plant, this study was undertaken to verify the plausible anticancer effect of leaf methanol extracts of A...
December 2021: Libyan Journal of Medicine
https://read.qxmd.com/read/33067297/protocol-of-a-prospective-multicentre-phase-i-study-to-evaluate-the-safety-tolerability-and-preliminary-efficacy-of-the-bispecific-psmaxcd3-antibody-cc-1-in-patients-with-castration-resistant-prostate-carcinoma
#22
JOURNAL ARTICLE
Jonas S Heitmann, Juliane S Walz, Martin Pflügler, Joseph Kauer, Richard F Schlenk, Gundram Jung, Helmut R Salih
INTRODUCTION: Prostate cancer is the second most common cancer in men worldwide. When the disease becomes resistant to androgen-deprivation therapy, treatment options are sparse. To address the high medical need in castration-resistant prostate cancer (CRPC), we generated a novel PSMAxCD3 bispecific antibody termed CC-1. CC-1 binds to prostate-specific membrane antigen that is expressed on prostate cancer cells and tumour vessels, thereby allowing a dual anticancer effect. METHODS AND ANALYSIS: This first in human clinical study is a prospective and multicentre trial which enrols patients with metastatic CRPC after failure of established third-line therapy...
October 16, 2020: BMJ Open
https://read.qxmd.com/read/33054567/evaluation-of-different-haematoxylin-stain-subtypes-for-the-optimal-microscopic-interpretation-of-cutaneous-malignancy-in-mohs-frozen-section-histological-procedure
#23
JOURNAL ARTICLE
J A Gabriel, M Shams, G E Orchard
BACKGROUND: The Mohs technique employs mainly H&E-stained frozen sections for surgical margin assessment of cutaneous excisions, utilising microscopic evaluation of the complete, circumferential, peripheral and deep margins. This study aimed to determine which mordant based haematoxylin (Ehrlich's, Cole's, Mayer's, Gill's I, Gill's II, Gill's III, Weigert's, Harris' or Carazzi's) produced the optimal morphological clarity of staining for the identification of cellular and tissue morphology of cutaneous basal cell carcinoma (BCC)...
April 2021: British Journal of Biomedical Science
https://read.qxmd.com/read/33012510/in-vitro-and-in-vivo-antitumoral-activity-of-a-ternary-copper-ii-complex
#24
JOURNAL ARTICLE
Jeyson Césary Lopes, Françoise Vasconcelos Botelho, Marcelo José Barbosa Silva, Suélen Fernandes Silva, Lorena Polloni, Pedro Henrique Alves Machado, Tiago Rodrigues de Souza, Luiz Ricardo Goulart, Priscila Pereira Silva Caldeira, Elene Cristina Pereira Maia, Sandra Morelli, Robson J de Oliveira-Júnior
Recently, a high number of copper derivatives has been evaluated as DNA-targeting metallodrugs, due to the lower toxicity and its potential to cleave DNA. Several strategies have been testing to develop metal compounds effective against tumour cells. In this work, the ternary copper (doxycycline)-(1,10-phenanthroline) complex [Cu(dox)(phen)]2+ was especially designed as an antitumoral drug, previously showing high cytotoxicity and DNA cleavage activity. We aimed to further investigate the in vitro cytotoxic activity in both tumoral and non-tumoral cells, in vitro genotoxic potential, and in vivo antitumor activity using BALB/C mouse injected with sarcoma S180 and Ehrlich cell lines...
December 17, 2020: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/32945360/design-synthesis-and-biomedical-evaluation-of-mostotrin-a-new-water-soluble-tryptanthrin-derivative
#25
JOURNAL ARTICLE
Alexander Popov, Anna Klimovich, Olga Styshova, Taisiya Moskovkina, Andrey Shchekotikhin, Natalia Grammatikova, Lyubov Dezhenkova, Dmitry Kaluzhny, Peter Deriabin, Andrey Gerasimenko, Anatoly Udovenko, Valentin Stonik
Mostotrin (MT), a novel compound, at least five orders of magnitude more soluble in water than its mother substance, was designed and synthesised from tryptanthrin (TR). Its structure was established by nuclear magnetic resonance and mass spectrometry data and confirmed by X‑ray analysis, revealing that MT is a pentacyclic product with an additional pseudo‑cycle formed with the participation of one intramolecular hydrogen bond. Antimicrobial activity and cytotoxic action against tumour cells in vitro, as well as anti‑tumour effects, acute toxicity and anti‑inflammatory activities in vivo, were evaluated...
October 2020: International Journal of Molecular Medicine
https://read.qxmd.com/read/32781964/antiproliferative-activity-and-apoptotic-efficiency-of-syzygium-cumini-bark-methanolic-extract-against-eac-cells-in-vivo
#26
JOURNAL ARTICLE
Ayesha Siddika, Plabon K Das, Saharia Y Asha, Suraiya Aktar, Abu R M Tareq, Ayesha Siddika, Abdur Rakib, Farhadul Islam, Jahan Ara Khanam
BACKGROUND: Syzygium cumini is one of the evidence-based traditional medicinal plant used in the treatment of various ailments. OBJECTIVES: Herein, the antioxidant property and anticancer property of Syzygium cumini against Ehrlich Ascites Carcinoma (EAC) cells were examined to find effective chemotherapeutics. METHODS: In vitro assays, and phytochemical and chromatographic analyses were used to determine antioxidant properties and chemical constituents of Syzygium cummini Bark Methanolic Extract (SCBME)...
2021: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/32645253/long-term-survival-following-elective-colon-cancer-surgery-in-the-aged-a-population-based-cohort-study
#27
JOURNAL ARTICLE
S Niemeläinen, H Huhtala, A Ehrlich, J Kössi, E Jämsen, M Hyöty
AIM: The number of colorectal cancer patients increases with age. Long-term data support personalized management due to heterogeneity within the older population. This registry- and population-based study aimed to analyse long-term survival, and causes of death, after elective colon cancer surgery in the aged, focusing on patients who survived more than 3 months postoperatively. METHODS: The data included patients ≥ 80 years who had elective surgery for Stage I-III colon cancer in four Finnish centres...
November 2020: Colorectal Disease
https://read.qxmd.com/read/32470490/the-hypoxic-tumour-microenvironment-a-safe-haven-for-immunosuppressive-cells-and-a-therapeutic-barrier-to-overcome
#28
REVIEW
Wai Hoong Chang, Alvina G Lai
Dating back to the seminal work of Paul Ehrlich, the idea of harnessing our immune system to eliminate cancerous cells is now over a century old. In the presence of a functional immune system that so efficiently guards the host against developing neoplasms, tumour cells must evolve sophisticated strategies to escape immune destruction in order to give rise to clinically detectable cancers. A new way of treating cancer would thus be to target the immune system itself rather than the tumour, and extensive studies in randomised trials have cemented the possibility of using immunotherapy for treating advanced-stage cancers...
September 1, 2020: Cancer Letters
https://read.qxmd.com/read/32318657/hematological-reference-values-and-animal-welfare-parameters-of-balb-c-fmabc-mus-musculus-inoculated-with-ehrlich-tumor-kept-in-the-vivarium-at-abc-medical-school
#29
JOURNAL ARTICLE
Patrick Gabriel Dos Santos Pessini, Paula Regina Knox de Souza, Camila Dos Santos Chagas, Emily Garcia Sampaio, Daniel Santos Neves, Giuliana Petri, Fernando Luiz Affonso Fonseca, Emerson Barbosa da Silva
Background: Biochemical and hematological parameters are important tools for assessing the physiological profile of vital organs, and can be recorded to create reference values used for clinical diagnosis of diseases. Many research laboratories lack the means to establish their own set of reference parameters for use in their research, and while there are articles in the literature that discuss laboratory parameters for healthy BALB/c mice, few studies address the evaluation of these parameters in pathological situations, such as in mice inoculated with Ehrlich tumor...
March 2020: Animal Models and Experimental Medicine
https://read.qxmd.com/read/32024617/the-therapeutic-and-antineoplastic-effects-of-vitamin-b17-against-the-growth-of-solid-form-ehrlich-tumours-and-the-associated-changes-in-oxidative-stress-dna-damage-apoptosis-and-proliferation-in-mice
#30
JOURNAL ARTICLE
Thanaa A El-Masry, Nora H Al-Shaalan, Ehab Tousson, Manal Buabeid, Anhar M Alyousef
Many cancer therapies indirectly activate apoptosis by chemical or physical damage of DNA. This study was performed to evaluate protective potential of vitamin B17 (VitB17) against Ehrlich solid tumor (EST) induced changes in the oxidative stress, DNA damage, apoptosis and proliferation in mice. In the experiment, 60 female CD1 mice were randomly and allocated to the following four equal-sized groups [G1, negative control; G2, positive control (VitB17); G3, untreated EST; G4, EST treated with VitB17 (EST+VitB17)]...
November 2019: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/31701302/surgery-for-the-complex-wilms-tumour
#31
REVIEW
Sharon Cox, Cenk Büyükünal, Alastair J W Millar
The prognosis of children with Wilms tumour has greatly improved since the introduction of adjuvant radiotherapy and chemotherapy more than 70 years ago with a current overall long-term survival approaching 90%. Before this, surgery was the only option with around 20% survival, even in low-risk categories. The focus is now on management options for those patients in specific subgroups, who continue to have lower event-free survival and who suffer from the long-term effects of treatment. These include those with anaplastic histology, bilateral Wilms, biologically high-risk tumours and those that relapse (Aldrink et al...
February 2020: Pediatric Surgery International
https://read.qxmd.com/read/31699182/comparison-of-epidemiological-clinical-and-microbiological-characteristics-of-bloodstream-infection-in-children-with-solid-tumours-and-haematological-malignancies
#32
COMPARATIVE STUDY
M M Garrido, R Q Garrido, T N Cunha, S Ehrlich, I S Martins
Bloodstream infection (BSI) is a serious complication in immunocompromised hosts. This study compares epidemiological, clinical and microbiological characteristics of BSI among children with haematological malignancies (HM) and solid tumours (ST). The study was conducted from October 2012 through to November 2015 at a referral hospital for cancer care and included the first BSI episode detected in 210 patients aged 18 years or less. BSI cases were prospectively detected by daily laboratory-based surveillance...
November 8, 2019: Epidemiology and Infection
https://read.qxmd.com/read/31325873/treatment-of-stage-i-anaplastic-wilms-tumour-a-report-from-the-children-s-oncology-group-aren0321-study
#33
JOURNAL ARTICLE
Najat C Daw, Yueh-Yun Chi, Yeonil Kim, Elizabeth A Mullen, John A Kalapurakal, Jing Tian, Geetika Khanna, James I Geller, Elizabeth J Perlman, Peter F Ehrlich, Anne B Warwick, Paul E Grundy, Conrad V Fernandez, Jeffrey S Dome
BACKGROUND: In the fifth National Wilms Tumor Study (NWTS-5), the 4-year event-free survival (EFS) and overall survival (OS) estimates for 29 patients with stage I focal (n = 10) or diffuse (n = 19) anaplastic Wilms' tumour (AWT) treated with vincristine and dactinomycin without flank radiation were 69.5% and 82.6%, respectively. The Children's Oncology Group AREN0321 study evaluated whether adding doxorubicin and flank radiation improves survival for these patients. PATIENTS AND METHODS: Tumour histology and stage were confirmed by real-time central pathology, surgery and radiology review...
September 2019: European Journal of Cancer
https://read.qxmd.com/read/31284823/dna-hypermethylation-in-disease-mechanisms-and-clinical-relevance
#34
JOURNAL ARTICLE
Melanie Ehrlich
Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-malignant diseases. This is consistent with numerous findings about differentiation-associated changes in DNA methylation at promoters, enhancers, gene bodies, and sites that control higher-order chromatin structure. Abnormal increases or decreases in DNA methylation contribute to or are markers for cancer formation and tumour progression. Aberrant DNA methylation is also associated with neurological diseases, immunological diseases, atherosclerosis, and osteoporosis...
December 2019: Epigenetics: Official Journal of the DNA Methylation Society
https://read.qxmd.com/read/31066091/ameliorative-effects-of-melatonin-against-solid-ehrlich-carcinoma-progression-in-female-mice
#35
JOURNAL ARTICLE
Ali H Amin, Mohamed A El-Missiry, Azza I Othman, Doaa A Ali, Mona S Gouida, Ahmed H Ismail
The current work estimated the antitumour efficacy of melatonin (MLT) on the growth of Ehrlich ascites carcinoma cells inoculated intramuscularly into the hind limbs of female BALB/c mice and to compare its effects with those of adriamycin (ADR). After solid tumours developed, the animals were divided into the three following groups: the tumour-bearing control, MLT-treated (20 mg/kg body weight) and ADR-treated (10 mg/kg body weight) groups. The results showed a significant reduction in the tumour masses of the treated animals in comparison with those of the control group...
September 2019: Journal of Pineal Research
https://read.qxmd.com/read/30970513/synthesis-of-coumarin-analogs-appended-with-quinoline-and-thiazole-moiety-and-their-apoptogenic-role-against-murine-ascitic-carcinoma
#36
JOURNAL ARTICLE
T Prashanth, B R Vijay Avin, Prabhu Thirusangu, V Lakshmi Ranganatha, B T Prabhakar, J N Narendra Sharath Chandra, Shaukath Ara Khanum
The synthesis and antiproliferative effect of a series of quinoline and thiazole containing coumarin analogs 12a-d and 13a-f respectively, on mice leukemic cells was performed. The chemical structures of newly synthesized compounds were confirmed by IR, 1 H NMR, 13 C NMR and mass spectral analysis. The result indicates that, 7-methoxy-2-oxo-2H-chromene-3-carboxylic acid [4-(4-methoxy-phenyl)-thiazol-2-yl]-amide (13f) showed potent activity against EAC and DLA cells in MTT (15.3 μM), tryphan blue (15.6 μM) and LDH (14...
April 2019: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/30935273/treatment-of-breast-cancer-with-engineered-novel-ph-sensitive-triaryl-z-olefin-niosomes-containing-hydrogel-an-in-vitro-and-in-vivo-study
#37
JOURNAL ARTICLE
Heba F Salem, Rasha M Kharshoum, Amr Gamal F, Fatma I Abo El-Ela, Khaled R A Abdellatif
Triaryl-(Z)-olefin (TZO) was synthesized as a Tamoxifen (TMX) analogue for breast cancer treatment to avoid developing the resistance and toxicity of TMX. TZO was synthesized using McMurry olefination reaction and has anti-cancer activity better than TMX by two folds. In this paper, in situ pH-sensitive TZO-loaded noisome hydrogel was prepared for delivering and targeting TZO to its site of activity. Equi-molar of cholesterol and span 60 was used to prepare TZO-loaded niosomes using the Hand Shaking Method...
April 1, 2019: Journal of Liposome Research
https://read.qxmd.com/read/30634942/safety-and-efficacy-of-afatinib-as-add-on-to-standard-therapy-of-gemcitabine-cisplatin-in-chemotherapy-naive-patients-with-advanced-biliary-tract-cancer-an-open-label-phase-i-trial-with-an-extensive-biomarker-program
#38
JOURNAL ARTICLE
Markus Moehler, Annett Maderer, Anne Ehrlich, Friedrich Foerster, Arno Schad, Tanja Nickolay, Christian Ruckes, Arndt Weinmann, Visvakanth Sivanathan, Jens U Marquardt, Peter Robert Galle, Marcus Woerns, Thomas Thomaidis
BACKGROUND: To date, the cornerstone of treatment in patients with advanced or metastatic cholangiocarcinoma (CCA) is systemic chemotherapy based on a combination of gemcitabine and a platinum derivative. Other therapeutic approaches including targeted agents and tyrosine kinase inhibitors (TKI) have demonstrated disappointing results, highlighting the complexity of CCA. Recently, drugs aiming at the inhibition of HER-receptors have shown first therapeutic benefit in patients with late stage disease...
January 11, 2019: BMC Cancer
https://read.qxmd.com/read/30624093/chemotherapeutic-potential-of-novel-non-toxic-nucleoside-analogues-on-eac-ascitic-tumour-cells
#39
JOURNAL ARTICLE
Atish Barua, Pritha Choudhury, Joy Krishna Maity, Sukhendu Bikash Mandal, Suvra Mandal, Prosenjit Saha
Therapeutic efficacy of nucleoside analogues (NAs) like Gemcitabine, 5-fluorouracil in cancer treatment is already well established. Most of the known NAs are highly toxic to normal cells due to its non-specific action; thus searching for non-toxic NAs are still going on. For that purpose we have synthesised nine different NAs by alteration of their structural and functional groups. The aim of present study is to investigate the therapeutic potential of NAs against mice bearing breast adenocarcinoma cells at IC50 dose for 10 days treatment schedule...
January 2019: Free Radical Research
https://read.qxmd.com/read/30471201/regulatory-mechanisms-of-t-cell-activation-from-basic-research-discoveries-to-a-new-principle-of-cancer-therapy-and-the-nobel-prize
#40
EDITORIAL
Juha P Väyrynen, Anne Tuomisto, Markus J Mäkinen
No abstract text is available yet for this article.
November 24, 2018: Acta Physiologica
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