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JOURNAL ARTICLE
Sumit Singh Verma, Avadhesh, Ankit Srivastava, Anusmita Shekher, Anupam Dhasmana, Acharan Singh Narula, Subash Chandra Gupta
UNLABELLED: ims: The aim of this study was to evaluate the combined and comparative efficacy of Caffeic acid phenethyl ester (CAPE) and curcumin in breast cancer. BACKGROUND: CAPE and curcumin are a class of phenolics. While curcumin is obtained from turmeric, CAPE is found in Baccharis sarothroides and Populus deltoides. Both agents are reported to produce activities in some cancer types. The combined and comparative effects of the two agents in breast cancer have not yet reported...
March 21, 2024: Current Medicinal Chemistry
#2
JOURNAL ARTICLE
Nurujjaman, Tanjila Mashhoor, Tasfik Ui Haque Pronoy, Abdul Auwal, Robiul Hasan, Shaikh Shohidul Islam, Imtiaj Hasan, A K M Asaduzzaman, Md Belal Uddin, Syed Rashel Kabir, Farhadul Islam
BACKGROUND: Lectins are carbohydrate-binding proteins with various pharmacological activities, such as antimicrobial, antidiabetic, antioxidant, and anticancer. Punica granatum fruit extract has traditional uses, however, the anti-cancer activity of purified lectin isolated from P. granatum pulp is yet to be reported. OBJECTIVE: The goals of this study are purification, characterization of the lectin from P. granatum, and examination of the purified lectin's anticancer potential...
November 30, 2023: Anti-cancer Agents in Medicinal Chemistry
#3
JOURNAL ARTICLE
R M Elgharabawy, E Tousson, I E El Sayed, A H Abd El-Aleim, M Elabd, D T Gebreel, A S Ahmed
OBJECTIVE: The limitations faced by conventional drug delivery systems are being overcome through the use of rapidly evolving cancer nanotherapeutics. Determining the manner in which the Ehrlich solid tumor (EST) is impacted by the new bioactive Alanda-loaded flax seed gum nanoparticles (Alanda NPs) functioning as an anti-carcinogenic agent represents the research objective of this paper. MATERIALS AND METHODS: Identification of the functional groups, surface morphology, particle size, and zeta potential were among the characterizations and preparations made for the prepared nanoparticles...
October 2023: European Review for Medical and Pharmacological Sciences
#4
JOURNAL ARTICLE
A T Keshta, Hanaa Kh Ashour
Novel and effective treatments are urgently needed for cancer, which is still the leading cause of death in the world. Biological characteristics linked to thiazole derivatives span a wide range. Thiazole derivatives are used in the creation of medications for therapy as well. The aim of current study is to evaluate the anticancer and antioxidant properties of the newly synthesized thiazole derivatives, compounds 1 and 2, on Ehrlich ascites carcinoma (EAC) cells in female mice. Our findings indicated that thiazole derivatives, compounds 1 and 2 have anticancer activity by elevating the p53 expression and cytochrome c levels in groups treated with compounds 1 and 2 compared to the positive control group...
June 2023: Doklady. Biochemistry and Biophysics
#5
JOURNAL ARTICLE
Waseem Raza, Abha Meena, Suaib Luqman
Flavonoids are among the largest groups of secondary metabolites. Studies suggest that dietary intake of flavonoids reduces the risk of cancer. 3,5,7-trihydroxyflavone (THF) belongs to the flavone class of flavonoids and potentially inhibits the growth of many cancers; however, it is unexplored in prostate cancer. This study reports the antiproliferative potential of THF in prostate cancer cell line via reactive oxygen species (ROS)-mediated cascades and examines the tumour reduction potential in swiss albino mice...
July 21, 2023: Journal of Biochemical and Molecular Toxicology
#6
JOURNAL ARTICLE
Darko Kučan, Nada Oršolić, Dyana Odeh, Snježana Ramić, Boris Jakopović, Jelena Knežević, Maja Jazvinšćak Jembrek
The aim of this study was to investigate the therapeutic potential of resveratrol in combination with cisplatin on the inhibition of tumour angiogenesis, growth, and macrophage polarization in mice bearing the solid form of an Ehrlich ascites tumour (EAT) that were exposed to whole-body hyperthermia treatment. In addition, we investigated whether a multimodal approach with hyperthermia and resveratrol could abolish cisplatin resistance in tumour cells through the modulation of histone deacetylase (HDAC) activity and levels of heat shock proteins (HSP70/HSP90) and contribute to the direct toxicity of cisplatin on tumour cells...
July 4, 2023: International Journal of Molecular Sciences
#7
JOURNAL ARTICLE
Samar Imbaby, Shereen E Elkholy, Salwa Faisal, Asmaa K K Abdelmaogood, Amir E Mehana, Basma S A Mansour, Samar M Abd El-Moneam, Samah M Elaidy
AIMS: Ehrlich ascites carcinoma and its subcutaneous inoculated solid tumour form (SEC) are reliable models for chemotherapeutic molecular targets exploration. Novel chemotherapeutic approaches are identified as molecular targets for intrinsic apoptosis, like the modulation of the second mitochondria-derived activator of caspases (SMAC). SMAC is a physiological substrate of mitogen-activated protein kinases (MAPKs). Glutathione-S-transferase P1 (GSTP1) and its close association with MAPKs play an important role in malignant cell proliferation, metastasis, and resistance to chemotherapeutics...
February 21, 2023: Life Sciences
#8
REVIEW
Noor Azleen Mohamad, Amirah Abdul Rahman, Siti Hamimah Sheikh Abdul Kadir
Piper betle leaves are widely cultivated in Malaysia, India, Indonesia and Thailand. They have been used as a traditional medicine for centuries due to their medicinal properties, including antioxidant, antiproliferative, antibacterial, antifungal and anti-inflammatory properties, which are attributable to their high phenolic contents. Hydroxychavicol (HC), a primary constituent of P. betle leaves, is known to possess antiproliferative activity at micromolar doses on various cancer cell lines of different origins while leaving normal cells unharmed...
January 2023: Oncology Letters
#9
JOURNAL ARTICLE
Sina M Coldewey, Charles Neu, Frank Bloos, Philipp Baumbach, Ulrike Schumacher, Michael Bauer, Philipp Reuken, Andreas Stallmach
BACKGROUND: Despite the intense global research endeavour to improve the treatment of patients with COVID-19, the current therapy remains insufficient, resulting in persisting high mortality. Severe cases are characterised by a systemic inflammatory reaction driven by the release of pro-inflammatory cytokines such as IL-6 and tumour-necrosis-factor alpha (TNF-α). TNF-α-blocking therapies have proved beneficial in patients with chronic inflammatory diseases and could therefore pose a new treatment option in COVID-19...
September 2, 2022: Trials
#10
JOURNAL ARTICLE
Meghana Manjunath, Sai Swaroop, Sai Sanwid Pradhan, Raksha Rao K, Raghunandan Mahadeva, Venketesh Sivaramakrishnan, Bibha Choudhary
Transcriptomic profiling of several drugs in cancer cell lines has been utilised to obtain drug-specific signatures and guided combination therapy to combat drug resistance and toxicity. Global metabolomics reflects changes due to altered activity of enzymes, environmental factors, etc. Integrating transcriptomics and metabolomics can provide genotype-phenotype correlation, providing meaningful insights into alterations in gene expression and its outcome to understand differential metabolism and guide therapy...
July 6, 2022: Genes
#11
JOURNAL ARTICLE
B M M Baharoon, A M Shaik, Salim M El-Hamidy, Rady Eid El-Araby, Ashwaq H Batawi, Mohamed Abdel Salam
Herein, the impact of the halloysite nanotubes to suppress the side effects of Asparaginase (ANase) cellular proliferation was investigated. Methods: A total of 100 adult male mice was employed. These mice were divided into four equal groups; Group 1 (control), Group 2 (ESC group) of a single dose of 0.15 ml Ehrlich cells (2 × 106 ) intraperitoneal infusion(IP), Group 3 (ESC + ANase group) received six doses equal treatments of Intratumoral (IT) 0.07 ml Aspragnase (7 mg/kg) over two weeks. For two weeks, Group 4 (ESC + ASNase + HNTs) received an IT administration of 0...
May 2022: Saudi Journal of Biological Sciences
#12
JOURNAL ARTICLE
Claire Daien, Marek Krogulec, Paul Gineste, Jean-Marc Steens, Laurence Desroys du Roure, Sophie Biguenet, Didier Scherrer, Julien Santo, Hartmut Ehrlich, Patrick Durez
OBJECTIVE: This phase 2a randomised, double blind, placebo controlled, parallel group study evaluated the safety and efficacy of a first-in-class drug candidate ABX464 (obefazimod, 50 mg and 100 mg per day), which upregulates the biogenesis of the mRNA inhibitor micro-RNA (miR)-124, in combination with methotrexate (MTX) in 60 patients (1:1:1 ratio) with moderate-to-severe active rheumatoid arthritis (RA) who have inadequate response to MTX or/and to an anti-tumour necrosis factor alpha (TNFα) therapy...
May 31, 2022: Annals of the Rheumatic Diseases
#13
JOURNAL ARTICLE
Elisabeta Ioana Chera, Raluca Maria Pop, Marcel Pârvu, Olga Sorițău, Ana Uifălean, Florinela Adriana Cătoi, Andra Cecan, Andrada Gabriela Negoescu, Patriciu Achimaș-Cadariu, Alina Elena Pârvu
The antitumoral, antioxidant, and anti-inflammatory effects of flaxseed ethanol extract was screened. Phytochemical analysis was performed by measuring the total phenolic content and by HPLC-DAD-ESI MS. In vitro antiproliferative activity was appreciated by MMT test of four adenocarcinomas and two normal cell lines. In vitro, antioxidant activity was evaluated by DPPH, FRAP, H2 O2 , and NO scavenging tests. The in vivo growth inhibitory activity against Ehrlich ascites carcinoma (EAC) in female BALB/c mice was determined using the trypan blue test...
April 30, 2022: Antioxidants (Basel, Switzerland)
#14
JOURNAL ARTICLE
Shubham Thakur, Rasdeep Kour, Satwinderjeet Kaur, Subheet Kumar Jain
The present study aims to develop carboplatin injectable microspheres using spray-drying technology. The optimized powdered microspheres (MS-19-ST2) were morphologically spherical, with a 1.795 μm particle size and good micromeritic properties. Under normal temperature conditions, the MS-19-ST2 formulation exhibited a sustained release behaviour following first-order drug release kinetics with no compatibility issues with aluminium syringes. Furthermore, MS-19-ST2 formulation outperformed its commercial counterpart in terms of in vivo pharmaco-kinetics and -dynamics (MRT-13...
April 28, 2022: AAPS PharmSciTech
#15
JOURNAL ARTICLE
Afnan A Alqarni, Aliaa A Alamoudi, Rasha M Allam, Ghada M Ajabnoor, Steve M Harakeh, Ahmed M Al-Abd
Breast cancer remains a leading cause of female mortality worldwide. Therefore, novel complementary treatments have been sought. Recently, there has been a growing interest in investigating the possible complementary effects of polyphenolic compounds against various malignancies. In the present study, using MCF-7 and MDA-MB-231 human breast adenocarcinoma cells, the anticancer efficacy of a polyphenolic mixture (PFM) was investigated. PFM is composed of curcumin, resveratrol, epigallocatechin gallate, and quercetin...
May 2022: Biomedicine & Pharmacotherapy
#16
JOURNAL ARTICLE
Daniela Ančić, Nada Oršolić, Dyana Odeh, Matea Tomašević, Ivan Pepić, Snježana Ramić
There has been a significant research interest in nanocrystals as a promising technology for improving the therapeutic efficacy of poorly water-soluble drugs, such as resveratrol. Little is known about the interaction of nanocrystals with biological tissue. The aim of this study was to investigate the potential use of resveratrol (RSV) and its nanocrystals (NANO-RSV) as antitumor agents in Ehrlich ascites tumour (EAT)-bearing mice and the interaction of nanocrystals with biological tissue through biochemical and histological changes of kidney, liver and EAT cells...
January 15, 2022: Toxicology and Applied Pharmacology
#17
REVIEW
Andrew Dj Pearson, Claudia Rossig, Crystal Mackall, Nirali N Shah, Andre Baruchel, Gregory Reaman, Rosanna Ricafort, Delphine Heenen, Abraham Bassan, Michael Berntgen, Nick Bird, Eric Bleickardt, Najat Bouchkouj, Peter Bross, Carrie Brownstein, Sarah Beaussant Cohen, Teresa de Rojas, Lori Ehrlich, Elizabeth Fox, Stephen Gottschalk, Linda Hanssens, Douglas S Hawkins, Ivan D Horak, Danielle H Taylor, Courtney Johnson, Dominik Karres, Franca Ligas, Donna Ludwinski, Maksim Mamonkin, Lynley Marshall, Behzad K Masouleh, Yousif Matloub, Shannon Maude, Joe McDonough, Veronique Minard-Colin, Koen Norga, Karsten Nysom, Alberto Pappo, Laura Pearce, Rob Pieters, Martin Pule, Alfonso Quintás-Cardama, Nick Richardson, Martina Schüßler-Lenz, Nicole Scobie, Martina A Sersch, Malcolm A Smith, Jaroslav Sterba, Sarah K Tasian, Brenda Weigel, Susan L Weiner, Christian Michel Zwaan, Giovanni Lesa, Gilles Vassal
The seventh multi-stakeholder Paediatric Strategy Forum focused on chimeric antigen receptor (CAR) T-cells for children and adolescents with cancer. The development of CAR T-cells for patients with haematological malignancies, especially B-cell precursor acute lymphoblastic leukaemia (BCP-ALL), has been spectacular. However, currently, there are scientific, clinical and logistical challenges for use of CAR T-cells in BCP-ALL and other paediatric malignancies, particularly in acute myeloid leukaemia (AML), lymphomas and solid tumours...
January 2022: European Journal of Cancer
#18
RANDOMIZED CONTROLLED TRIAL
Vishal C Patel, Sunjae Lee, Mark J W McPhail, Kevin Da Silva, Susie Guilly, Ane Zamalloa, Elizabeth Witherden, Sidsel Støy, Godhev Kumar Manakkat Vijay, Nicolas Pons, Nathalie Galleron, Xaiohong Huang, Selin Gencer, Muireann Coen, Thomas Henry Tranah, Julia Alexis Wendon, Kenneth D Bruce, Emmanuelle Le Chatelier, Stanislav Dusko Ehrlich, Lindsey Ann Edwards, Saeed Shoaie, Debbie Lindsay Shawcross
BACKGROUND & AIMS: Rifaximin-α is efficacious for the prevention of recurrent hepatic encephalopathy (HE), but its mechanism of action remains unclear. We postulated that rifaximin-α reduces gut microbiota-derived endotoxemia and systemic inflammation, a known driver of HE. METHODS: In a placebo-controlled, double-blind, mechanistic study, 38 patients with cirrhosis and HE were randomised 1:1 to receive either rifaximin-α (550 mg BID) or placebo for 90 days...
February 2022: Journal of Hepatology
#19
COMMENT
Peter Ehrlich
No abstract text is available yet for this article.
April 2022: Journal of Pediatric Surgery
#20
JOURNAL ARTICLE
Sadiya Khwaja, Kaneez Fatima, Divya Mishra, Vineet Babu, Yogesh Kumar, Sumera Banu Malik, Misbah Tabassum, Suaib Luqman, Dnyaneshwar U Bawankule, Debabrata Chanda, Feroz Khan, Dilip M Mondhe, Arvind S Negi
Indanocine, a potent anticancer investigational drug of National Cancer Institute-USA, has been much discussed in recent years. Present communication aimed at total synthesis of indanocine and its close analogues. Total synthesis was improved by double yields than previously reported yields. Some of the benzylidene and 2-benzyl derivatives with free rotation at C2 position exhibited potential cytotoxicities against various human cancer cell lines. Five such analogues exhibited potential antiproliferative effect against HCT-116 and MIA PACA-2 cell lines...
July 2021: Chemical Biology & Drug Design
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