keyword
MENU ▼
Read by QxMD icon Read
search

Ehrlich tumour

keyword
https://www.readbyqxmd.com/read/27756009/magnetic-nanoparticle-induced-hyperthermia-with-appropriate-payloads-paul-ehrlich-s-magic-nano-bullet-for-cancer-theranostics
#1
N R Datta, S Krishnan, D E Speiser, E Neufeld, N Kuster, S Bodis, H Hofmann
Effective multimodal cancer management requires the optimal integration of diagnostic and therapeutic modalities. Radiation therapy, chemotherapy and immunotherapy, alone or in combination, are integral parts of various cancer treatment protocols. Hyperthermia at 39-45°C is a potent radiosensitiser and has been shown to improve therapeutic outcomes in various tumours through its synergy with chemotherapy. Gene silencing approaches, using small interfering RNAs and microRNAs, are also being explored in clinical trials in oncology...
October 3, 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27378625/oxidative-stress-polarization-of-macrophages-and-tumour-angiogenesis-efficacy-of-caffeic-acid
#2
Nada Oršolić, Martina Kunštić, Marina Kukolj, Romana Gračan, Johann Nemrava
Macrophage polarization is a process when macrophage expresses different functional programs in response to microenvironmental signals and two extreme forms exist; M1 and M2 macrophages. M1 macrophages are highly microbicidal and anticancer with enhanced ability to kill and phagocytose pathogens, upregulate pro-inflammatory cytokines and reactive molecular species, and present antigens; M2 macrophages and the related tumour associated macrophages (TAMs) regulate tissue remodelling and promote tissue repair and angiogenesis and can amplification of metabolic pathways that can suppress adaptive immune responses...
August 25, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27350017/induction-of-apoptosis-in-ehrlich-ascites-tumour-cells-via-p53-activation-by-a-novel-small-molecule-mdm2-inhibitor-lqfm030
#3
Mariana F da Mota, Alane P Cortez, Polyana L Benfica, Bruna Dos S Rodrigues, Thalyta F Castro, Larissa M Macedo, Carlos H Castro, Luciano M Lião, Flávio S de Carvalho, Luiz A S Romeiro, Ricardo Menegatti, Hugo Verli, Bianca Villavicencio, Marize C Valadares
OBJECTIVE: The activation of the p53 pathway through the inhibition of MDM2 has been proposed as a novel therapeutic strategy against tumours. A series of cis-imidazoline analogues, termed nutlins, were reported to displace the recombinant p53 protein from its complex with MDM2 by binding to MDM2 in the p53 pocket, and exhibited an antitumour activity both in vitro and in vivo. Thus, the purpose of this study was to evaluate the antitumour properties of LQFM030 (2), a nutlin analogue created by employing the strategy of molecular simplification...
September 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27225970/evaluation-of-in-vitro-antioxidant-anticancer-and-in-vivo-antitumour-activity-of-termitomyces-clypeatus-mtcc-5091
#4
Arijit Mondal, Debopam Banerjee, Rajib Majumder, Tapan Kumar Maity, Suman Khowala
CONTEXT: Termitomyces clypeatus (Lyophyllaceae) is a filamentous edible mushroom, having ethnomedicinal uses. However, information about the antioxidant, anticancer and antitumour properties of this mushroom remains to be elucidated. OBJECTIVE: The study examines the in vitro antioxidant, anticancer and in vivo antitumour activity of T. clypeatus. MATERIALS AND METHODS: Antioxidant activity was evaluated with seven in vitro assays. Cytotoxicity of T...
May 25, 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27188870/ganoderma-lucidum-total-triterpenes-attenuate-dla-induced-ascites-and-eac-induced-solid-tumours-in-swiss-albino-mice
#5
T P Smina, J Mathew, K K Janardhanan
G. lucidum total triterpenes were assessed for its apoptosis-inducing and anti-tumour activities. The ability of the total triterpenes to induce apoptosis was evaluated in Dalton's lymphoma ascites (DLA) and Ehrlich's ascites carcinoma (EAC) cell lines. Total triterpenes were found to be highly cytotoxic to DLA and EAC cell lines with IC50 values 5 ± 0.32 and 7.9 ± 0.2 µg/ml respectively. Total triterpenes induced apoptosis in both cell lines which is evident from the DNA fragmentation assay. Anti-tumour activity was accessed using DLA induced solid and EAC induced ascites tumour models in Swiss albino mice...
2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/26997691/cytotoxic-and-antitumour-studies-of-acetoacetanilide-n-4-methyl-phenyl-thiosemicarbazone-and-its-transition-metal-complexes
#6
N P Priya, A P Firdous, R Jeevana, K K Aravindakshan
Cytotoxic activities of acetoacetanilide N(4)-methyl(phenyl)thiosemicarbazone (L2H) and its seven different metal complexes were studied. Of these, IC50 value of the copper complex was found to be 46 μg/ml. Antitumour studies of this copper complex was carried out using Daltons Lymphoma Ascites cell-induced solid tumour model and Ehrlich's Ascites Carcinoma cell-induced ascites tumour model. Administration of the copper complex at different concentrations (10, 5 and 1 mg/kg b. wt) inhibited the solid tumour development in mice and increased the mean survival rate and the life span of Ascites tumour bearing mice in a concentration dependent manner...
November 2015: Indian Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26939285/anti-tumour-activity
#7
(no author information available yet)
Experimental tumours have great importance for the purposes of modelling where Dalton's ascites lymphoma (DAL) and Ehrlich ascites carcinoma (EAC) are the commonest. It appeared firstly as a spontaneous breast cancer in a female mouse and then Ehrlich and Apolant (Berlin KlinWshr 28:871-874, 1905) used it as an experimental tumour by transplanting tumour tissues subcutaneously from mouse to mouse. In 1932, Loewenthal and Jahn obtained the liquid form in the peritoneum of the mouse and named it as 'Ehrlich ascites carcinoma' due to the ascites liquid, together with the carcinoma cells...
2016: Progress in Drug Research. Fortschritte der Arzneimittelforschung. Progrès des Recherches Pharmaceutiques
https://www.readbyqxmd.com/read/26548747/phenethyl-isothiocyanate-potentiates-anti-tumour-effect-of-doxorubicin-through-akt-dependent-pathway
#8
Nada H Eisa, Nehal M ElSherbiny, Abdelhadi M Shebl, Laila A Eissa, Mamdouh M El-Shishtawy
The present study aims to investigate the in vivo and in vitro anti-tumour properties of phenethyl isothiocyanate (PEITC) alone and in combination with doxorubicin (Dox). The anti-tumour activity was evaluated in vitro by MTT assay using cultured human breast cancer cell line (MCF-7) and human hepatoma cell line (HepG-2) cell lines. In vivo, Ehrlich solid tumour model was used. Tumour volume, weight and antioxidant parameters were determined. Immunohistochemistry analysis for active (cleaved) caspase-3 was also performed...
December 2015: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/26218335/evaluation-of-cytotoxic-and-antitumour-properties-of-apodytes-dimidiata-and-characterisation-of-the-bioactive-component
#9
Menon Kunnathully Divya, Sasidharan Salini, Thomas Chubicka, Achuthan Chathrattil Raghavamenon, Thekkekara Devassy Babu
Apodytes dimidiata, belonging to the family Icacinaceae, is used for treating inflammation and various gastrointestinal ailments in Zulu traditional medicine. In the present study, significant cytotoxicity was exhibited by the methanolic extract of the A. dimidiata leaf against various cancer cell lines. The extract was purified partially through silica gel column by successive elution using various solvents of increasing polarity. Among these, the active methanolic fraction was found to be the most cytotoxic with IC50 values ranging from 0...
December 2015: Planta Medica
https://www.readbyqxmd.com/read/26019604/biological-evaluation-of-new-potential-anticancer-agent-for-tumour-imaging-and-radiotherapy-by-two-methods-99m-tc-radiolabelling-and-epr-spectroscopy
#10
Yanka Karamalakova, Krishna Chuttani, Rakesh Sharma, Antoaneta Zheleva, Veselina Gadjeva, Anil Mishra
Recently, a new class of in vitro and ex vivo radiotracers/radioprotectors, the nitroxyl-labelled agent 1-ethyl-1-nitroso-3-[4-(2,2,6,6-tetramethylpiperidine-1-oxyl)]-urea (SLENU), has been discovered. Our previous investigations demonstrated that SLENU is a low-molecular-weight stable free radical which is freely membrane permeable, easily crosses the blood brain barrier and exhibited in/ex vivo the lowest general toxicity and higher anticancer activity against some experimental tumour models. Further investigation was aimed to develop a (99m)Tc-labelled SLENU (97%) as a chelator and evaluate its labelling efficiency and potential use as a tumour seeking agent and for early diagnosis...
November 2, 2014: Biotechnology, Biotechnological Equipment
https://www.readbyqxmd.com/read/25933717/anticancer-activity-and-toxicity-profiles-of-2-benzylidene-indanone-lead-molecule
#11
Aastha Singh, Kaneez Fatima, Arjun Singh, Akansha Behl, M J Mintoo, Mohammad Hasanain, Raghib Ashraf, Suaib Luqman, Karuna Shanker, D M Mondhe, Jayanta Sarkar, Debabrata Chanda, Arvind S Negi
3-(3',4',5'-Trimethoxyphenyl)-4,5,6-trimethoxy,2-(3″,4″-methylenedioxybenzylidene)-indan-1-one (1) is an optimized anti-cancer lead molecule obtained on modification of gallic acid, a plant phenolic acid. It exhibited potent cytotoxicities (IC50=0.010-14.76μM) against various human carcinoma cells. In cell cycle analysis, benzylidene indanone 1 induced G2/M phase arrest in both MCF-7 and MDA-MB-231 cells. It also induced apoptosis in DU145 cells which was evident by cleavage of PARP. In Ehrlich ascites carcinoma, benzylidene indanone 1 showed 45...
August 30, 2015: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/25290651/use-of-radiolabelled-monoclonal-anti-cea-antibodies-for-the-detection-of-human-carcinomas-by-external-photoscanning-and-tomoscintigraphy
#12
J P Mach, F Buchegger, M Forni, J Ritschard, C Berche, J D Lumbroso, M Schreyer, C Girardet, R S Accolla, S Carrel
Paul Ehrlich's inspired concept of 'magic bullets' for the cure of diseases has been revitalized by recent advances in immunology(1). In particular, the development of cell fusion technology allowing the production of monoclonal antibodies (Mabs) with exquisite specificities(2) triggered new hopes that we may now have the perfect carrier molecules with which to deliver cytotoxic drugs(3) or toxins(4) to the hidden cancer cells. This article reviews data on one aspect of the magic bullet concept, the use of radiolabelled antibodies as tracers for tumour localization...
December 1981: Immunology Today
https://www.readbyqxmd.com/read/25212156/antioxidant-and-cytoprotective-properties-of-2-hydroxymethyl-3-methoxybenzaldehyde
#13
Anup Srivastava, T Shivanandappa
Currently there is a great deal of interest in the study of natural compounds with free radical scavenging activity because of their potential role in maintaining human health and preventing diseases. In this paper, we report the antioxidant and cytoprotective properties of 2-(hydroxymethyl)-3-methoxybenzaldehyde (HMMB) isolated from the aqueous extract of Decalepis hamiltonii roots. Our results show that HMMB is a potent scavenger of superoxide (O2(-)), hydroxyl (OH), nitric oxide (NO), and lipid peroxide (LOO) physiologically relevant free radicals with IC50 values in the nmolar (5-214) range...
September 15, 2011: Food Chemistry
https://www.readbyqxmd.com/read/25000506/biochemical-analysis-and-antitumour-effect-of-abrus-precatorius-agglutinin-derived-peptides-in-ehrlich-s-ascites-and-b16-melanoma-mice-tumour-model
#14
Birendra Behera, K Sanjana P Devi, Debasish Mishra, Swatilekha Maiti, Tapas K Maiti
Anticancer and immunostimulatory properties of tryptic digest peptides of Abrus precatorius agglutinin protein (10kDAGP) have already been reported. Here attempt has been made to further validate anticancer properties of 10kDAGP peptides in Ehrlich's ascites carcinoma (EAC) and B16 melanoma (B16M) bearing mice models and to analyze 10kDAGP by anion exchange chromatography and RP-HPLC for obtaining the bioactive fraction from the total peptide pool. 10kDAGP treatment decreased the tumour pack volume by ∼82% for EAC and 58...
July 2014: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/24643721/higher-insulin-sensitivity-and-impaired-insulin-secretion-in-cachetic-solid-ehrlich-tumour-bearing-mice
#15
N M Violato, A Rafacho, A C Boschero, J R Bosqueiro
Insulin secretion is mainly regulated by blood glucose concentration. On the other hand, changes in peripheral insulin sensitivity induce compensatory adaptations in pancreatic β-cells to maintain normoglycaemia. Tumour presence causes dramatic alterations in glucose homeostasis and insulin secretion because of the high glucose consumption by the tumour cells. Here, we investigated insulin secretion in solid Ehrlich tumour-bearing mice in association with cachexia. For that, male adult Swiss mice were subcutaneously inoculated with solid Ehrlich tumour cells and sacrificed at 14 days after tumour implantation (SET), while control mice received saline alone (CTL)...
August 2014: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/24556035/b-1-cells-and-concomitant-immunity-in-ehrlich-tumour-progression
#16
M C Azevedo, M C Palos, L Osugui, M F Laurindo, D Masutani, S Nonogaki, A L L Bachi, F H M Melo, M Mariano
Concomitant immunity is a phenomenon in which a tumour-bearing host is resistant to the growth of an implanted secondary tumour. Metastases are considered to be secondary tumours that develop spontaneously during primary tumour growth, suggesting the involvement of concomitant immunity in controlling the rise of metastases. It has been demonstrated that B-1 cells, a subset of B-lymphocytes found predominantly in pleural and peritoneal cavities, not only increase the metastatic development of murine melanoma B16F10, but also are capable of differentiating into mononuclear phagocytes, modulating inflammatory responses in wound healing, in oral tolerance and in Paracoccidiose brasiliensis infections...
May 2014: Immunobiology
https://www.readbyqxmd.com/read/24311885/an-experimental-study-on-the-anti-ehrlich-ascites-carcinoma-effect-of-purified-toad-venom-extract
#17
Ying Wang
The objective of this paper was to study the anti-Ehrlich ascites carcinoma effect of purified toad venom extract and its mechanism. Mouse model of Ehrlich ascites carcinoma was established with cisplatin as the control to observe the inhibitory effect of purified toad venom extract on malignant peritoneal effusion in mice. The results showed that compared with the control group, ascites volume, number of tumour cells and tumour cell viability decreased and ascites inhibition rate reached over 50% in each treatment group, and with the increase of the dose, incidence of ascites showed a downward trend...
2013: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/24311854/study-on-anti-ehrlich-ascites-tumour-effect-of-pinellia-ternata-polysaccharide-in-vivo
#18
Xiaogang Li, Ping Lu, Wanfu Zhang, Bo Li, Rong Yang, Kaiyuan Luo
The objectives of the study were to investigate the anti-tumour activity of Pinellia ternata polysaccharide in vivo, and to preliminarily explore the possible mechanism of its antitumour action. Mouse model of Ehrlich ascites tumour (solid tumour) was used to detect the serum SOD, MDA and GSH-Px levels in mouse and to measure the tumour inhibition rate and survival prolongation rate. The results showed that Pinellia ternata polysaccharide had some tumour inhibitory effect. Tumour weight of Pinellia ternata polysaccharide high-dose group was highly significantly different (P<0...
2013: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/24066514/antitumour-and-anti-inflammatory-effects-of-palladium-ii-complexes-on-ehrlich-tumour
#19
Marcela B Quilles, Camila B A Carli, Sandra R Ananias, Lucas S Ferreira, Livia C A Ribeiro, Danielle C G Maia, Flávia A Resende, Antônio C Moro, Eliana A Varanda, Marisa Campos Polesi Placeres, Antonio E Mauro, Iracilda Z Carlos
Palladium(II) complexes are an important class of cyclopalladated compounds that play a pivotal role in various pharmaceutical applications. Here, we investigated the antitumour, anti-inflammatory, and mutagenic effects of two complexes: [Pd(dmba)(Cl)tu] (1) and [Pd(dmba)(N3)tu] (2) (dmba = N,N-dimethylbenzylamine and tu = thiourea), on Ehrlich ascites tumour (EAT) cells and peritoneal exudate cells (PECs) from mice bearing solid Ehrlich tumour. The cytotoxic effects of the complexes on EAT cells and PECs were assessed using the 3-(4,5-dimethylthiazol-3-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay...
July 2013: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/24060507/quercetin-enhances-the-effect-of-hyperthermal-intraperitoneal-chemotherapy-with-cisplatin-in-mice
#20
Nada Oršolić, Nikola Car
Hyperthermal treatment is a promising approach for cancer therapy, because it not only kills cancer cells directly, but it also activates anti-cancer immunity as an indirect effect. In addition, hyperthermia enhances the clastogenicity of alkylating agents. The objective of this study was to determine whether quercetin (QU) has the potential to serve as a beneficial supplement before hyperthermal intraperitoneal chemotherapy (HIPEC) with cisplatin and whether quercetin can reduce the clastogenic effect of cisplatin (CIS) on healthy tissue in mice bearing the Ehrlich ascites tumour (EAT)...
September 20, 2013: Mutation Research
keyword
keyword
9060
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"