keyword
https://read.qxmd.com/read/38536552/il-6-enhances-the-activation-of-pi3k-akt-mtor-gsk-3%C3%AE-by-upregulating-grpr-in-hippocampal-neurons-of-autistic-mice
#1
JOURNAL ARTICLE
Heli Li, Xinyuan Wang, Cong Hu, Jinru Cui, Hao Li, Xiaoping Luo, Yan Hao
Autism spectrum disorder (ASD) is a neurological disorder associated with brain inflammation. The underlying mechanisms could be attributed to the activation of PI3K signaling in the inflamed brain of ASD. Multiple studies highlight the role of GRPR in regulating ASD like abnormal behavior and enhancing the PI3K signaling. However, the molecular mechanism by which GRPR regulates PI3K signaling in neurons of individuals with ASD is still unclear. In this study, we utilized a maternal immune activation model to investigate the effects of GRPR on PI3K signaling in the inflamed brain of ASD mice...
March 27, 2024: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/38536538/competing-endogenous-rnas-crosstalk-in-hippocampus-a-potential-mechanism-for-neuronal-developing-defects-in-down-syndrome
#2
JOURNAL ARTICLE
Huiru Zhao, Guiyu Lou, Yupu Shao, Tao Wang, Hongdan Wang, Qiannan Guo, Wenke Yang, Hongyan Liu, Shixiu Liao
Down syndrome (DS) is the most example of aneuploidy, resulting from an additional copy of all or part of chromosome 21. Competing endogenous RNAs (ceRNAs) play important roles in neuronal development and neurological defects. This study aimed to identify hub genes and synergistic crosstalk among ceRNAs in the DS fetal hippocampus as potential targets for the treatment of DS-related neurodegenerative diseases. We profiled differentially expressed long non-coding RNAs (DElncRNAs), differentially expressed circular RNAs (DEcircRNAs), differentially expressed microRNAs (DEmiRNAs), and differentially expressed messenger RNAs (DEmRNAs) in hippocampal samples from patients with or without DS...
March 27, 2024: Journal of Molecular Neuroscience: MN
https://read.qxmd.com/read/38535468/induction-of-autophagy-by-extract-from-corydalis-heterocarpa-for-skin-anti-aging
#3
JOURNAL ARTICLE
Kyeong Eun Yang, Soo-Bin Nam, Ga-Eun Lee, Gabsik Yang, Mee-Hyun Lee, Geul Bang, Jung Hoon Choi, Yong-Yeon Cho, Cheol-Jung Lee
The extracts of Corydalis heterocarpa , a salt-tolerant plant, exhibit diverse physiological properties, including anti-inflammatory, anticancer, and antiadipogenic effects. However, the anti-aging effects of C. heterocarpa extract (CHE) on human skin cells have not yet been investigated. In the present study, we determined that CHE inhibited senescence-associated β-galactosidase (SA-β-gal)-stained senescent human dermal fibroblasts (HDFs). Furthermore, CHE markedly suppressed the expression of major regulatory proteins involved in senescence, including p53, p21, and caveolin-1...
March 8, 2024: Marine Drugs
https://read.qxmd.com/read/38535454/exploring-the-potential-of-crassostrea-nippona-hydrolysates-as-dietary-supplements-for-mitigating-dexamethasone-induced-muscle-atrophy-in-c2c12-cells
#4
JOURNAL ARTICLE
M J M S Kurera, D P Nagahawatta, N M Liyanage, H H A C K Jayawardhana, D S Dissanayake, Hyo-Geun Lee, Young-Sang Kim, Sang In Kang, You-Jin Jeon
Muscle atrophy is a detrimental and injurious condition that leads to reduced skeletal muscle mass and disruption of protein metabolism. Oyster ( Crassostrea nippona ) is a famous and commonly consumed shellfish in East Asia and has become a popular dietary choice worldwide. The current investigation evaluated the efficacy of C. nippona against muscle atrophy, which has become a severe health issue. Mammalian skeletal muscles are primarily responsible for efficient metabolism, energy consumption, and body movements...
February 28, 2024: Marine Drugs
https://read.qxmd.com/read/38534508/contractile-and-genetic-characterization-of-cardiac-constructs-engineered-from-human-induced-pluripotent-stem-cells-modeling-of-tuberous-sclerosis-complex-and-the-effects-of-rapamycin
#5
JOURNAL ARTICLE
Veniamin Y Sidorov, Tatiana N Sidorova, Philip C Samson, Ronald S Reiserer, Clayton M Britt, M Diana Neely, Kevin C Ess, John P Wikswo
The implementation of three-dimensional tissue engineering concurrently with stem cell technology holds great promise for in vitro research in pharmacology and toxicology and modeling cardiac diseases, particularly for rare genetic and pediatric diseases for which animal models, immortal cell lines, and biopsy samples are unavailable. It also allows for a rapid assessment of phenotype-genotype relationships and tissue response to pharmacological manipulation. Mutations in the TSC1 and TSC2 genes lead to dysfunctional mTOR signaling and cause tuberous sclerosis complex (TSC), a genetic disorder that affects multiple organ systems, principally the brain, heart, skin, and kidneys...
February 28, 2024: Bioengineering
https://read.qxmd.com/read/38534333/cd74-promotes-cyst-growth-and-renal-fibrosis-in-autosomal-dominant-polycystic-kidney-disease
#6
JOURNAL ARTICLE
Julie Xia Zhou, Alice Shasha Cheng, Li Chen, Linda Xiaoyan Li, Ewud Agborbesong, Vicente E Torres, Peter C Harris, Xiaogang Li
The progression of autosomal dominant polycystic kidney disease (ADPKD), an inherited kidney disease, is associated with renal interstitial inflammation and fibrosis. CD74 has been known not only as a receptor of macrophage migration inhibitory factor (MIF) it can also have MIF independent functions. In this study, we report unknown roles and function of CD74 in ADPKD. We show that knockout of CD74 delays cyst growth in Pkd1 mutant kidneys. Knockout and knockdown of CD74 (1) normalize PKD associated signaling pathways, including ERK, mTOR and Rb to decrease Pkd1 mutant renal epithelial cell proliferation, (2) decrease the activation of NF-κB and the expression of MCP-1 and TNF-alpha (TNF-α) which decreases the recruitment of macrophages in Pkd1 mutant kidneys, and (3) decrease renal fibrosis in Pkd1 mutant kidneys...
March 11, 2024: Cells
https://read.qxmd.com/read/38533302/biomedicines-in-longevity-and-aging-the-quest-to-resist-biological-decline
#7
REVIEW
Raymond D Palmer
Aging is considered part of the natural process of life, however in recent years medical literature has started to show that specific facets of aging are beginning to be understood and those factors may even be considered preventable with various measures. Aging is also considered the number one cause of poor quality of life, disease, disability, and death, so the importance of understanding the aging process and how to control certain aspects of it cannot be underestimated when age related suffering is factored in...
2024: BioMedicine
https://read.qxmd.com/read/38532930/targeting-of-lysosomal-bound-protein-meak-7-for-cancer-therapy
#8
REVIEW
Insoon Chang, Yi-Ling Loo, Jay Patel, Joe Truong Nguyen, Jin Koo Kim, Paul H Krebsbach
mEAK-7 (mammalian EAK-7 or MTOR-associated protein, eak-7 homolog), is an evolutionarily conserved lysosomal membrane protein that is highly expressed in several cancer cells. Multiple recent studies have identified mEAK-7 as a positive activator of mTOR (mammalian/mechanistic target of rapamycin) signaling via an alternative mTOR complex, implying that mEAK-7 plays an important role in the promotion of cancer proliferation and migration. In addition, structural analyses investigating interactions between mEAK-7 and V-ATPase, a protein complex responsible for regulating pH homeostasis in cellular compartments, have suggested that mEAK-7 may contribute to V-ATPase-mediated mTORC1 activation...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38532826/neuropathology-and-epilepsy-surgery-2024-update
#9
JOURNAL ARTICLE
Ingmar Blümcke
Neuropathology-based studies in neurosurgically resected brain tissue obtained from carefully examined patients with focal epilepsies remain a treasure box for excellent insights into human neuroscience, including avenues to better understand the neurobiology of human brain organization and neuronal hyperexcitability at the cellular level including glio-neuronal interaction. It also allows to translate results from animal models in order to develop personalized treatment strategies in the near future. A nice example of this is the discovery of a new disease entity in 2017, termed mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy or MOGHE, in the frontal lobe of young children with intractable seizures...
January 2024: Free neuropathology
https://read.qxmd.com/read/38532450/lymphangioleiomyomatosis-in-patients-with-tuberous-sclerosis-a-national-centre-audit
#10
JOURNAL ARTICLE
Jan Johnson, Wendy Somerfield, Simon R Johnson
BACKGROUND: Lymphangioleiomyomatosis (LAM) is common in tuberous sclerosis complex (TSC) yet under recognised with management mostly based upon evidence obtained from patients with sporadic LAM. We performed a prospective audit of patients with TSC-LAM attending a national referral centre to inform management guidelines. METHODS: The UK LAM Centre was established in 2011 and conducts a prospective audit of pre-defined quality outcomes for all subjects. Audit data are reported on all patients with TSC-LAM and a comparator population of patients with sporadic LAM...
March 26, 2024: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/38532150/exploring-the-combined-anti-cancer-effects-of-sodium-butyrate-and-celastrol-in-glioblastoma-cell-lines-a-novel-therapeutic-approach
#11
JOURNAL ARTICLE
Bahar Kartal, Farika Nur Denizler-Ebiri, Mustafa Güven, Filiz Taşpınar, Hande Canpınar, Sedat Çetin, Tuğçe Karaduman, Serkan Küççüktürk, Javier Castresana, Mehmet Taşpınar
Glioblastoma, a highly aggressive and lethal brain cancer, lacks effective treatment options and has a poor prognosis. In our study, we explored the potential anti-cancer effects of sodium butyrate (SB) and celastrol (CEL) in two glioblastoma cell lines. SB, a histone deacetylase inhibitor, and CEL, derived from the tripterygium wilfordii plant, act as mTOR and proteasome inhibitors. Both can cross the blood-brain barrier, and they exhibit chemo- and radiosensitive properties in various cancer models. GB cell lines LN-405 and T98G were treated with SB and CEL...
March 26, 2024: Medical Oncology
https://read.qxmd.com/read/38531978/homocysteine-metabolites-inhibit-autophagy-by-upregulating-mir-21-5p-mir-155-5p-mir-216-5p-and-mir-320c-3p-in-human-vascular-endothelial-cells
#12
JOURNAL ARTICLE
Łukasz Witucki, Hieronim Jakubowski
Nutritional and genetic deficiencies in homocysteine (Hcy) metabolism lead to hyperhomocysteinemia (HHcy) and cause endothelial dysfunction, a hallmark of atherosclerosis, which is a major cause of cardiovascular disease (CVD). Impaired autophagy causes the accumulation of damaged proteins and organelles and is associated with CVD. Biochemically, HHcy is characterized by elevated levels of Hcy and its metabolites, Hcy-thiolactone and N-Hcy-protein. However, whether these metabolites can dysregulate mTOR signaling and autophagy in endothelial cells is not known...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531974/exploring-the-potential-of-ziziphus-nummularia-and-luteolin-7-o-glucoside-as-tubulin-inhibitors-in-cancer-therapy-and-survival
#13
JOURNAL ARTICLE
Sahar Saleh Alghamdi, Sara Abdulaziz Alghashem, Rizwan Ali, Arwa Alsubait, Rasha Saad Suliman, Afrah E Mohammed, Zeyad Alehaideb, Raghad Abdullah Alshafi, Allulu Yousef Alturki, Ishrat Rahman
Cancer is responsible for approximately 10 million deaths worldwide, with 70% of the deaths occurring in low- and middle-income countries; as such safer and more effective anti-cancer drugs are required. Therefore, the potential benefits of Ziziphus nummularia and Ziziphus spina-christi as sources of anti-cancer agents were investigated. Z. nummularia and Z. spina-christi extracts were prepared using chloroform, ethanol, ethyl acetate, and water. The extracts' anti-cancer properties were determined using the MTT Cell Viability Assay in four cancer cell lines: breast (KAIMRC2 and MDA-MB-231), colorectal (HCT8), and liver (HepG2)...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531962/mtor-and-neuroinflammation-in-epilepsy-implications-for-disease-progression-and-treatment
#14
REVIEW
Teresa Ravizza, Mirte Scheper, Rossella Di Sapia, Jan Gorter, Eleonora Aronica, Annamaria Vezzani
Epilepsy remains a major health concern as anti-seizure medications frequently fail, and there is currently no treatment to stop or prevent epileptogenesis, the process underlying the onset and progression of epilepsy. The identification of the pathological processes underlying epileptogenesis is instrumental to the development of drugs that may prevent the generation of seizures or control pharmaco-resistant seizures, which affect about 30% of patients. mTOR signalling and neuroinflammation have been recognized as critical pathways that are activated in brain cells in epilepsy...
March 26, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38531793/characterizing-the-efficacy-and-safety-of-chemotherapy-plus-everolimus-in-her2-negative-metastatic-breast-cancer-harboring-altered-pi3k-akt-mtor
#15
JOURNAL ARTICLE
Rong Wang, Qiao-Yan Zhu, Wei-Wu Ye, Yuan Huang, Zhan-Hong Chen, Ya-Bing Zheng, Xiao Zou, Jian Wang, Dan-Lu Jiang, Xiao-Jia Wang, Zheng-Yang Xu, Wen-Ming Cao
BACKGROUND: The clinical outcomes of chemotherapy (CT) for the treatment of metastatic triple-negative (TN) and hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (mBC) have proven to be disappointing. The phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway, a tumor-promoting signaling cascade frequently mutated in breast cancer (BC), has been implicated in chemoresistance...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531787/recent-progress-of-chitosan-nanoparticles-for-the-development-of-superior-delivery-of-vaccines
#16
JOURNAL ARTICLE
Moeka Nakashima, Naoko Suga, Yuka Ikeda, Sayuri Yoshikawa, Satoru Matsuda
Chitosan seems to be an innovative biological material potentially utilized as a nanoparticle carrier for drug delivery, which could be low toxic, biocompatible, and easy to prepare. Chitosan nanoparticles have been employed in gene delivery. As a type of multifunctional adjuvant, chitosan nanoparticles could activate the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway to induce cell protection and/or proliferation via the modulation of autophagy within dendritic cells. In general, adjuvants may improve the innate and/or adaptive immune responses to a vaccine antigen by facilitating the antigen presentation of antigen presenting cells such as dendritic cells...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38530586/rapamycin-increases-leukemia-cell-sensitivity-to-chemotherapy-by-regulating-mtorc1-pathway-mediated-apoptosis-and-autophagy
#17
JOURNAL ARTICLE
Jing Xu, Siwen Zong, Tianle Sheng, Jifu Zheng, Qiong Wu, Qingming Wang, Aiping Tang, Yuan Song, Yan Fei, Zhenjiang Li
This study investigated the effect of rapamycin alone and in combination with chemotherapy (doxorubicin and cytarabine) on AML. Human acute monocytic leukemia cell line SHI-1 and NPG AML model mice created by intravenous injection of SHI-1 cell were treated with rapamycin, chemotherapy, or rapamycin plus chemotherapy. Analysis by cell counting kit-8, western blot, flow cytometry, and immunohistochemistry was performed, and results suggested that both rapamycin and chemotherapy inhibited proliferation of SHI-1 cells both in vitro and in vivo, suppressed neoplasm growth in vivo, and promoted survival of NPG AML mice...
March 26, 2024: International Journal of Hematology
https://read.qxmd.com/read/38529619/se-methylselenocysteine-ameliorates-mitochondrial-function-by-targeting-both-mitophagy-and-autophagy-in-the-mouse-model-of-alzheimer-s-disease
#18
JOURNAL ARTICLE
Yongli Xie, Xiaoshan Ke, Zhencong Ye, Xuexia Li, Zetao Chen, Jiantao Liu, Ziyi Wu, Qiong Liu, Xiubo Du
Background : Alzheimer's disease (AD) exerts tremendous pressure on families and society due to its unknown etiology and lack of effective treatment options. Our previous study had shown that Se-methylselenocysteine (SMC) improved the cognition and synaptic plasticity of triple-transgenic AD (3 × Tg-AD) mice and alleviated the related pathological indicators. We are dedicated to investigating the therapeutic effects and molecular mechanisms of SMC on mitochondrial function in 3 × Tg-AD mice. Methods : Transmission electron microscopy (TEM), western blotting (WB), mitochondrial membrane potential (Δ Ψ m ), mitochondrial swelling test, and mitochondrial oxygen consumption test were used to evaluate the mitochondrial morphology and function...
March 26, 2024: Food & Function
https://read.qxmd.com/read/38529403/superior-performance-of-biocomposite-nanoparticles-plga-res-in-protecting-oocytes-against-vitrification-stimuli
#19
JOURNAL ARTICLE
Guiping Hai, Jiachen Bai, Yucheng Liu, Jun Li, Aiju Liu, Jingjing Wang, Qian Liu, Weijun Liu, Pengcheng Wan, Xiangwei Fu
Irreversible cryogenic damage caused by oocyte vitrification limits its widespread use in female fertility preservation. In recent years, nanoparticles (NPs) have gained great attention as potential alternatives in protecting oocytes against cryoinjuries. In this paper, a novel composite nanoparticle, poly (lactic-co-glycolic acid)-resveratrol (PLGA-RES) was designed to improve the biocompatibility and sustained release properties by encapsulating natural antioxidant RES into PLGA NPs. Firstly, biotoxicity and oxidation resistance of PLGA-RES were determined, and the results showed that PLGA-RES had nontoxic effect on oocyte survival during in vitro maturation (IVM) (97...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38528297/intermittent-fasting-shifts-the-diurnal-transcriptome-atlas-of-transcription-factors
#20
JOURNAL ARTICLE
Min Fu, Siyu Lu, Lijun Gong, Yiming Zhou, Fang Wei, Zhigui Duan, Rong Xiang, Frank J Gonzalez, Guolin Li
Intermittent fasting remains a safe and effective strategy to ameliorate various age-related diseases, but its specific mechanisms are not fully understood. Considering that transcription factors (TFs) determine the response to environmental signals, here, we profiled the diurnal expression of 600 samples across four metabolic tissues sampled every 4 over 24 h from mice placed on five different feeding regimens to provide an atlas of TFs in biological space, time, and feeding regimen. Results showed that 1218 TFs exhibited tissue-specific and temporal expression profiles in ad libitum mice, of which 974 displayed significant oscillations at least in one tissue...
March 25, 2024: Molecular and Cellular Biochemistry
keyword
keyword
906
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.