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Blount disease

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https://www.readbyqxmd.com/read/27741108/guided-growth-for-tibia-vara-blount-s-disease
#1
John A Heflin, Scott Ford, Peter Stevens
Blount's disease is commonly attributed to an intrinsic, idiopathic defect in the posteromedial proximal tibial physis resulting in progressive bowing of the leg, intoeing, and lateral knee thrust. Treatment has historically included bracing, physeal stapling, or corrective osteotomy, and was determined primarily by age at presentation. As we feel the pathology is not necessarily age dependent, we have elected to use the technique of guided growth using a lateral tension band plate to correct limb alignment as a first-line treatment in all patients presenting to our clinic as long as they had growth remaining and no evidence of a physeal bar...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27729673/gefitinib-and-sonidegib
#2
EDITORIAL
Corey J Medler, J Aubrey Waddell, Dominic A Solimando
The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr, President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, VA 22203, e-mail: OncRxSvc@comcast...
November 2015: Hospital Pharmacy
https://www.readbyqxmd.com/read/27698500/arsenic-trioxide-and-tretinoin-aso-atra-for-acute-promyelocytic-leukemia-apl
#3
Erin Damery, Dominic A Solimando, J Aubrey Waddell
The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr., President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, VA 22203, e-mail: OncRxSvc@comcast...
September 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27670949/pretransplant-patient-parent-and-family-psychosocial-functioning-varies-by-organ-type-and-patient-age
#4
Cyd K Eaton, Jennifer L Lee, Kristin A Loiselle, Bonney Reed-Knight, Laura L Mee, Ana M Gutierrez-Colina, Ronald L Blount
The goal of this study was to compare pretransplant patient HRQOL, parent psychological functioning, and the impact of the patient's ongoing illness on the family between organ types (ie, kidney, liver, heart) and age-groups (ie, children, AYAs). The sample included 80 pediatric patients with end-stage organ disease who were evaluated for transplantation and their parents. Parents completed self- and proxy reports at patients' pretransplant evaluations. Results indicated that patients evaluated for heart transplants consistently had lower HRQOL and their parents had greater psychological distress compared to the kidney and liver groups...
September 27, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27621503/clofarabine-and-cytarabine-regimen-for-acute-myeloid-leukemia
#5
EDITORIAL
Kristin V Ho, Dominic A Solimando, J Aubrey Waddell
The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr, President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, VA 22203, e-mail: OncRxSvc@comcast...
November 2015: Hospital Pharmacy
https://www.readbyqxmd.com/read/27559185/alectinib-ceritinib-elotuzumab-and-venetoclax
#6
J Aubrey Waddell, Dominic A Solimando
The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr, President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, VA 22203, e-mail: OncRxSvc@comcast...
July 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27558397/tuberculosis-progression-rates-in-u-s-immigrants-following-screening-with-interferon-gamma-release-assays
#7
Robert J Blount, Minh-Chi Tran, Charles K Everett, Adithya Cattamanchi, John Z Metcalfe, Denise Connor, Cecily R Miller, Jennifer Grinsdale, Julie Higashi, Payam Nahid
BACKGROUND: Interferon-gamma release assays may be used as an alternative to the tuberculin skin test for detection of M. tuberculosis infection. However, the risk of active tuberculosis disease following screening using interferon-gamma release assays in immigrants is not well defined. To address these uncertainties, we determined the incidence rates of active tuberculosis disease in a cohort of high-risk immigrants with Class B TB screened with interferon-gamma release assays (IGRAs) upon arrival in the United States...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27507901/design-and-methods-of-the-population-assessment-of-tobacco-and-health-path-study
#8
Andrew Hyland, Bridget K Ambrose, Kevin P Conway, Nicolette Borek, Elizabeth Lambert, Charles Carusi, Kristie Taylor, Scott Crosse, Geoffrey T Fong, K Michael Cummings, David Abrams, John P Pierce, James Sargent, Karen Messer, Maansi Bansal-Travers, Ray Niaura, Donna Vallone, David Hammond, Nahla Hilmi, Jonathan Kwan, Andrea Piesse, Graham Kalton, Sharon Lohr, Nick Pharris-Ciurej, Victoria Castleman, Victoria R Green, Greta Tessman, Annette Kaufman, Charles Lawrence, Dana M van Bemmel, Heather L Kimmel, Ben Blount, Ling Yang, Barbara O'Brien, Cindy Tworek, Derek Alberding, Lynn C Hull, Yu-Ching Cheng, David Maklan, Cathy L Backinger, Wilson M Compton
BACKGROUND: This paper describes the methods and conceptual framework for Wave 1 of the Population Assessment of Tobacco and Health (PATH) Study data collection. The National Institutes of Health, through the National Institute on Drug Abuse, is partnering with the Food and Drug Administration's (FDA) Center for Tobacco Products to conduct the PATH Study under a contract with Westat. METHODS: The PATH Study is a nationally representative, longitudinal cohort study of 45 971 adults and youth in the USA, aged 12 years and older...
August 8, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27470285/optimizing-transgene-configuration-and-protein-fusions-to-maximize-dopamine-production-for-the-gene-therapy-of-parkinson-s-disease
#9
Hannah J Stewart, G Scott Ralph, Liang Fong-Wong, Iain Strickland, Laura McCloskey, Lucy Barnes, Ian Blount, Owen Wells, Christelle J M Truran, Alan J Kingsman, Stéphane Palfi, Kyriacos A Mitrophanous
Pharmacological dopamine replacement therapies provide the most well-established treatments for Parkinson's disease (PD). However, these long-term treatments can lead to motor complications and off-target effects. ProSavin(®), a lentiviral vector (LV)-based gene therapy approach aimed at restoring local and continuous dopamine production, through delivery of three enzymes in the dopamine biosynthesis pathway, was demonstrated to be safe and well-tolerated in a phase I/II clinical study of patients with advanced PD...
September 2016: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/27408479/osteotomy-for-deformities-in-blount-disease-a-systematic-review
#10
REVIEW
Phedy Phedy, Paruhum Ulitua Siregar
No abstract text is available yet for this article.
September 2016: Journal of Orthopaedics
https://www.readbyqxmd.com/read/27354744/carboplatin-and-liposomal-doxorubicin-for-ovarian-cancer
#11
Jamie Nguyen, Dominic A Solimando, J Aubrey Waddell
The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr, President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, VA 22203, e-mail: OncRxSvc@comcast...
June 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27312797/solid-screw-insertion-for-tension-band-plates-a-surgical-technique-tip
#12
Muayad Kadhim, Ahmed I Hammouda, John E Herzenberg
PURPOSE: Growth modulation with tension band plates (TBPs) and cannulated screws is the current mainstay of treatment for pediatric lower extremity angular deformities. Solid screws have been used as an alternative to cannulated screws to decrease the risk of screw failure, particularly in obese children. The downside of solid screws is the decrease in precision of placement. This study describes a surgical technique to insert solid TBP screws accurately. METHODS: TBP insertion starts with the same conventional steps by inserting the guidewires into the epiphysis and metaphysis, straddling the physis...
August 2016: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/27303088/drug-monographs-ixazomib-and-necitumumab
#13
Fern E Lawson, J Aubrey Waddell, Dominic A Solimando
The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr, President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, VA 22203, e-mail: OncRxSvc@comcast...
May 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27303075/drug-monographs-daratumumab-and-osimertinib
#14
Dominic A Solimando, J Aubrey Waddell
The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr, President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, VA 22203, e-mail: OncRxSvc@comcast...
April 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27276637/vitamin-d-status-in-blount-disease
#15
Laughter Lisenda, Dina Simmons, Gregory B Firth, Yammesh Ramguthy, Thandrayen Kebashni, Anthony J F Robertson
INTRODUCTION: Blount disease can be defined as idiopathic proximal tibial vara. Several etiologies including the mechanical theory have been described. Obesity is the only causative factor proven to be associated with Blount disease. The aim of this study is to assess if there is an association of vitamin D deficiency and Blount disease. METHODS: This a retrospective study of preoperative and postoperative patients with Blount disease who were screened for vitamin D deficiency...
July 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27177940/blount-s-disease-a-rickets-mimicker
#16
Rana Bhattacharjee, Partha Pratim Chakraborty, Ajitesh Roy, Sugata Narayan Biswas
No abstract text is available yet for this article.
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27113015/mainstream-smoke-levels-of-volatile-organic-compounds-in-50-u-s-domestic-cigarette-brands-smoked-with-the-iso-and-canadian-intense-protocols
#17
Daniel Y Pazo, Fallon Moliere, Maureen M Sampson, Christopher M Reese, Kimberly A Agnew-Heard, Matthew J Walters, Matthew R Holman, Benjamin C Blount, Clifford H Watson, David M Chambers
INTRODUCTION: A significant portion of the increased risk of cancer and respiratory disease from exposure to cigarette smoke is attributed to volatile organic compounds (VOCs). In this study, 21 VOCs were quantified in mainstream cigarette smoke from 50U.S. domestic brand varieties that included high market share brands and 2 Kentucky research cigarettes (3R4F and 1R5F). METHODS: Mainstream smoke was generated under ISO 3308 and Canadian Intense (CI) smoking protocols with linear smoking machines with a gas sampling bag collection followed by solid phase microextraction/gas chromatography/mass spectrometry (SPME/GC/MS) analysis...
September 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27059923/the-aetiology-of-rickets-like-lower-limb-deformities-in-malawian-children
#18
V S Braithwaite, R Freeman, C L Greenwood, D M Summers, S Nigdikar, C B D Lavy, A C Offiah, N J Bishop, J Cashman, A Prentice
UNLABELLED: Debilitating rickets-like lower limb deformities are common in children throughout the world, particularly in Malawi, Africa where the causes are unknown. We have identified that Blount disease and calcium deficiency rickets are the likely causes of these deformities and propose calcium supplementation as a potential treatment of Malawian rickets. INTRODUCTION: Surgical correction of rickets-like lower limb deformities is the most common paediatric operation performed at Beit Cure Orthopaedic Hospital, Malawi...
July 2016: Osteoporosis International
https://www.readbyqxmd.com/read/26981042/management-of-infantile-blount-s-disease-with-molded-orthoses-a-new-perspective
#19
Nei Botter Montenegro, Bruno Sergio Ferreira Massa, Luiz Renato Agrizzi de Angeli
OBJECTIVE: : This retrospective study evaluated treatment with individually contoured molded bracing at early stages of the disease. METHODS: : We evaluated the medical records of patients undergoing treatment of Blount's disease with molded orthoses for medial decompression between 2010 and 2014. The deformity angle (Drennan's metaphyseal-diaphyseal angle) and Langenskiöld classification were measured before and after treatment by a pediatric orthopedic surgeon with over 5 years of practice, blinded for the study and patients...
March 2016: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/26912916/dinutuximab-and-panobinostat
#20
Ashley Chasick, Dominic A Solimando, J Aubrey Waddell
The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr, President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, VA 22203, e-mail: OncRxSvc@comcast...
October 2015: Hospital Pharmacy
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