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https://www.readbyqxmd.com/read/28551930/-laboratory-tests-and-radiological-imaging-diagnostic-tools-that-share-information-and-can-be-functionally-integrated
#1
Michael Mayer
In spite of apparent disparity between the specialties of radiological imaging, pathology and laboratory analysis, the medical diagnostic information that these sources provide have a lot in common and can be effectively utilized by sharing quantitative and qualitative results through modern information technology processes. Informaticsbased integration of radiological imaging, digital images of anatomical and molecular pathology and clinical laboratory results enables earlier, more sensitive and precise diagnosis, resulting in the more efficient treatment of patients...
March 2017: Harefuah
https://www.readbyqxmd.com/read/28551895/-sentinel-lymph-nodes-dissection-in-gynecological-malignancies
#2
REVIEW
Yael Naaman, Limor Goldenhersh, Alon Ben-Arie
During the last decade sentinel lymph nodes biopsy has become an essential part of primary surgical treatment in a number of malignancies including breast cancer, melanoma and head-and-neck malignancies. Dye or radioactive substances are injected at the primary tumor site, followed by pre-operative and intra-operative mapping. During surgery only positive lymph nodes are being dissected instead of a complete dissection of the lymphatic basin. The advantages of sentinel lymph nodes dissection are reducing the side effects of extensive lymph nodes dissection, while maintaining high detection rates and sensitivity in identifying cases with lymphatic tumor spread...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551847/prior-malignancies-in-patients-harboring-glioblastoma-an-institutional-case-study-of-2164-patients
#3
REVIEW
Brad E Zacharia, Natalie DiStefano, Marius M Mader, Muhammad O Chohan, Shahiba Ogilvie, Cameron Brennan, Philip Gutin, Viviane Tabar
More patients are surviving long-term following a cancer diagnosis and as such are at risk for second malignancies. As the most common primary brain tumor, glioblastoma (GBM) will not infrequently occur in this population. No study has examined the incidence of prior cancer (PC) in patients harboring GBM. Here we evaluate the epidemiological features, as well as the molecular and clinical characteristics of GBM as a second cancer. Utilizing a web-based cancer data management system at our institution, we identified 2164 patients harboring GBM from 2007 to 2014...
May 27, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28551844/a-pilot-study-of-minocycline-for-the-prevention-of-paclitaxel-associated-neuropathy-accru-study-ru221408i
#4
Deirdre R Pachman, Travis Dockter, Patricia J Zekan, Briant Fruth, Kathryn J Ruddy, Lauren E Ta, Jacqueline M Lafky, Todor Dentchev, Nguyet Anh Le-Lindqwister, William M Sikov, Nathan Staff, Andreas S Beutler, Charles L Loprinzi
PURPOSE: Paclitaxel is associated with both an acute pain syndrome (P-APS) and chronic chemotherapy-induced peripheral neuropathy (CIPN). Given that extensive animal data suggest that minocycline may prevent chemotherapy-induced neurotoxicity, the purpose of this pilot study was to investigate the efficacy of minocycline for the prevention of CIPN and the P-APS. METHODS: Patients with breast cancer were enrolled prior to initiating neoadjuvant or adjuvant weekly paclitaxel for 12 weeks and were randomized to receive minocycline 200 mg on day 1 followed by 100 mg twice daily or a matching placebo...
May 27, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28551814/macrophage-derived-interleukin-1beta-promotes-human-breast-cancer-cell-migration-and-lymphatic-adhesion-in-vitro
#5
Sarah J Storr, Sabreena Safuan, Narmeen Ahmad, Mohammed El-Refaee, Andrew M Jackson, Stewart G Martin
Lymphovascular invasion (LVI), encompassing blood and lymphatic vessel invasion, is an important event in tumourigenesis. Macrophages within the tumour microenvironment are linked to the presence of LVI and angiogenesis. This study investigates the role of macrophage-derived, caspase-1-dependent interleukin-1beta (IL-1β) in an in vitro model of LVI. IL-1β significantly augmented the adhesion and transmigration of breast cancer cell lines MCF7 and MDA-MB-231 across endothelial cell barriers. MDA-MB-231 and MCF7 showed a higher percentage of adhesion to lymphatic endothelial cells than blood endothelial cells following endothelial cell IL-1β stimulation (P < 0...
May 27, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28551737/recurrent-meningitis
#6
REVIEW
Jon Rosenberg, Benjamin T Galen
PURPOSE OF REVIEW: Recurrent meningitis is a rare clinical scenario that can be self-limiting or life threatening depending on the underlying etiology. This review describes the causes, risk factors, treatment, and prognosis for recurrent meningitis. As a general overview of a broad topic, the aim of this review is to provide clinicians with a comprehensive differential diagnosis to aide in the evaluation and management of a patient with recurrent meningitis. RECENT FINDINGS: New developments related to understanding the pathophysiology of recurrent meningitis are as scarce as studies evaluating the treatment and prevention of this rare disorder...
July 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28551704/erratum-to-effective-treatment-of-intractable-cutaneous-metastases-of-breast-cancer-with-electrochemotherapy-a-useful-contributor-to-cutaneous-disease-control
#7
M Bourke, D Soden, A J P Clover
No abstract text is available yet for this article.
May 27, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28551687/recent-highlights-of-research-on-androgen-receptors-in-women
#8
Kamil Zaręba, Iwona Sidorkiewicz
In this brief review we present an outline of the current state of research on examples of hyperandrogenism that can be strongly associated with diverse modifications in the androgen signaling pathway. We discuss the most prominent clinical features of androgen excess and correlate them with studies on androgen receptor (AR) alterations. For the first time we summarize the confirmed localizations of all known AR receptors in women. The knowledge of ARs may be the basis for AR-targeted therapies of androgenic disorders in women, including malignancy, as it has recently been demonstrated for triple-negative breast cancer...
2017: Developmental Period Medicine
https://www.readbyqxmd.com/read/28551685/concordance-of-her2-immunohistochemistry-and-fluorescence-in-situ-hybridization-using-tissue-microarray-in-breast-cancer
#9
Daniela Furrer, Simon Jacob, Chantal Caron, François Sanschagrin, Louise Provencher, Caroline Diorio
AIM: Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) are common methods for assessment of human epidermal growth factor receptor 2 (HER2) in breast cancer. MATERIALS AND METHODS: In a cohort of 498 consecutive patients with breast cancer, we examined concordance between IHC and FISH for HER2 on tissue microarray (TMA) sections. In a subset of 116 specimens, we examined HER2 concordance from the block used for diagnostics and a randomly-chosen additional block (a proxy of the core biopsy)...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551673/tissue-factor-expression-does-not-predict-mortality-in-breast-cancer-patients
#10
Simon F Stämpfli, Alexander Akhmedov, Silke Hausladen, Zsuzsanna Varga, Konstantin J Dedes, Jens Hellermann, Thomas F Lüscher, Glen Kristiansen, Felix C Tanner, Alexander Breitenstein
BACKGROUND: Tissue factor (TF), the trigger of coagulation, not only initiates thrombus formation, but also elicits tumor growth and invasion in breast cancer. However, the characterization of TF expression in breast cancer tissue and its prognostic value remain unclear. MATERIALS AND METHODS: Three hundred and three primary breast cancer specimens from the local tumor tissue database were immunostained for TF expression and evaluated semiquantitatively. Tumor characteristics (size, grade, nodal status, and ER expression) as well as patient's survival were assessed...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551653/clinical-relevance-of-serum-her2-and-circulating-tumor-cell-detection-in-metastatic-breast-cancer-patients
#11
Malgorzata Banys-Paluchowski, Isabell Witzel, Sabine Riethdorf, Brigitte Rack, Wolfgang Janni, Peter Andreas Fasching, Erich-Franz Solomayer, Bahriye Aktas, Sabine Kasimir-Bauer, Klaus Pantel, Tanja Fehm, Volkmar Müller
BACKGROUND/AIM: Presence of circulating tumor cells (CTCs) is associated with impaired survival in metastatic breast cancer (MBC). This study was designed to evaluate whether assessment of serum HER2 (sHER2) levels provide additional prognostic information in MBC. MATERIALS AND METHODS: Two hundred and fifty-three MBC patients were enrolled in this multicentre trial. CTCs were detected before the start of first- or later-line treatment using the CellSearch system...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551650/cytotrack-analysis-reveals-low-presence-of-circulating-tumor-cells-in-the-perioperative-period-in-patients-with-non-metastatic-colorectal-cancer
#12
Mikail Gogenur, Thore Hillig, Ismail Gogenur
BACKGROUND/AIM: Detection of circulating tumor cells in the perioperative period predicts poor prognosis in patients with colorectal cancer. There is only one Food and Drug Administration-approved method for such detection, CellSearch, for which results have been inconsistent. A new immunological method, CytoTrack, has shown promising results in patients with breast cancer. The aim of this study was to evaluate detection of circulating tumor cells in the peripheral blood of patients with non-metastatic colorectal cancer with CytoTrack, and investigate if there is a correlation between presence of circulating tumor cells and Union for International Cancer Control (UICC) stage and if surgery itself results in the release of circulating tumor cells...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551647/puzzling-results-from-bap1-germline-mutations-analysis-in-a-group-of-asbestos-exposed-patients-in-a-high-risk-area-of-northeast-italy
#13
Clara Rizzardi, Emmanouil Athanasakis, Francesca Cammisuli, Simeone Dal Monego, Yeraldin Chiquinquira Castillo DE Spelorzi, Fulvio Costantinides, Fabiola Giudici, Maurizio Pinamonti, Vincenzo Canzonieri, Mauro Melato, Lorella Pascolo
BACKGROUND: Germline mutations of the oncosuppressor gene breast cancer 1-associated protein 1 (BAP1) were recently related to an autosomal-dominant tumor predisposition syndrome (BAP1-TPDS), characterized by uveal melanoma, malignant mesothelioma (MM), cutaneous melanoma, and other malignancies. The demonstration that BAP1 mutations are strongly associated with MM has provided a real breakthrough in the study of genetic predisposition in MM, that may explain why only a fraction of asbestos-exposed individuals go on to develop MM...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551646/primary-peritoneal-serous-carcinoma-in-men-a-rare-and-non-brca-associated-entity
#14
Susan L Neuhausen, Hagit Shani, Lital Keinan Boker, Linda Steele, Barbara G Silverman, Laura Ottini, Valentina Silvestri, Yael Laitman, Jacob Korach, Tamar Perri, Eitan Friedman
BACKGROUND: Primary peritoneal serous carcinoma (PPSC) is a rare neoplasm. The paucity of reported cases among men may provide insight to the cell of origin of PPSC. MATERIALS AND METHODS: A search for the ICD 0-3 code of PPSC (C48.2) in the following datasets: the Israeli National Cancer registry (INCR), the Surveillance, Epidemiology, and End Results (SEER) database in the USA, Israeli male BRCA carriers, male high-risk and BRCA carriers in a USA study, and the Italian Study on Male Breast Cancer (MBC) were performed...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551632/the-prognostic-value-of-the-immunohistochemical-expression-of-phosphorylated-rb-and-p16-proteins-in-association-with-cyclin-d1-and-the-p53-pathway-in-a-large-cohort-of-patients-with-breast-cancer-treated-with-taxane-based-adjuvant-chemotherapy
#15
Theofani Gavressea, Konstantine T Kalogeras, Georgia-Angeliki Koliou, Flora Zagouri, Georgios Lazaridis, Helen Gogas, Kostas Tsigaridas, Angelos Koutras, Kalliopi Petraki, Christos Markopoulos, Elissavet Pazarli, Gerasimos Aravantinos, Christos Papadimitriou, Pavlos Papakostas, Nektarios Koufopoulos, Charisios Karanikiotis, Sofia Chrisafi, Haralambos P Kalofonos, Dimitrios Pectasides, George Fountzilas, Kitty Pavlakis
BACKGROUND: The retinoblastoma (RB) gene is a tumor-suppressor gene that plays a central role in regulating the cell cycle. Inactivation of this gene is involved in breast cancer. PATIENTS AND METHODS: A total of 827 patients with breast cancer treated with taxane-based adjuvant chemotherapy were included in the study. Protein expression of RB, phosphorylated RB (pRB), p16, cyclin D1 and p53 was evaluated by immunohistochemistry. RESULTS: Neither of the retinoblastoma markers (RB and pRB) reached statistical significance in terms of their association with disease-free or overall survival...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551627/the-cooh-terminus-of-the-igf-1ec-isoform-enhances-the-proliferation-and-migration-of-human-mcf-7-breast-cancer-cells
#16
Panagiotis F Christopoulos, Efstathia Papageorgiou, Constantina Petraki, Michael Koutsilieris
BACKGROUND/AIM: The insulin-like growth factor-1 (IGF-1) signaling is well implicated in cancer biology, however the potential roles of the distinct IGF-1 isoforms in human malignancies are largely unknown. Recently, the carboxyl-terminal of the IGF-1Ec variant (hEc; 24aa) has been associated with osteosarcoma and prostate cancer. Herein, we investigated the potential role of hEc in breast cancer. MATERIALS AND METHODS: Synthetic hEc peptide was administrated to MCF-7 and MDA-MB-231 breast cancer cells...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551626/lipoic-acid-decreases-the-viability-of-breast-cancer-cells-and-activity-of-ptp1b-and-shp2
#17
Alicja Kuban-Jankowska, Magdalena Gorska-Ponikowska, Michal Wozniak
BACKGROUND: Protein tyrosine phosphatases PTP1B and SHP2 are potential targets for anticancer therapy, because of the essential role they play in the development of tumors. PTP1B and SHP2 are overexpressed in breast cancer cells, thus inhibition of their activity can be potentially effective in breast cancer therapy. Lipoic acid has been previously reported to inhibit the proliferation of colon, breast and thyroid cancer cells. MATERIALS AND METHODS: We investigated the effect of alpha-lipoic acid (ALA) and its reduced form of dihydrolipoic acid (DHLA) on the viability of MCF-7 cancer cells and on the enzymatic activity of PTP1B and SHP2 phosphatases...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551619/structure-activity-relationship-of-niclosamide-derivatives
#18
Zhonghai Tang, Ulyana Muñoz Acuña, Nelson Freitas Fernandes, Somsundaram Chettiar, Pui-Kai Li, Esperanza Carcache DE Blanco
BACKGROUND/AIM: Cancer is a leading cause of death. Hence, this study aimed at the optimization of niclosamide derivatives for the development of new potential anticancer agents. MATERIALS AND METHODS: Niclosamide derivatives were synthesized and tested against a panel of human cancer cells: MDA and MCF7 breast cancer cells, PC3 and DU-145 prostate cancer cells, Hela cervical cancer cells, and HL-60 acute promyelocytic leukemia cells. They were also tested in nuclear factor-ĸappa B (NFĸB), V-Ki-ras2 Kirsten rat sarcoma viral oncogene (KRAS), and mitochondria transmembrane potential (MTP) assays...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551597/clozapine-re-exposure-after-dilated-cardiomyopathy
#19
Mariëtte Nederlof, Theo Wj Benschop, Cornelia Adriana de Vries Feyens, Eibert Roelof Heerdink
A 63-year-old woman with diabetes type II and a history of breast cancer was treated with clozapine for her refractory schizophrenia. She developed a dilated cardiomyopathy with an ejection fraction of 25%, a life-threatening event. The cause of heart failure could be multifactorial, with clozapine, family history, chemotherapy, diabetes type II and/or lithium as possible contributing risk factors. Clozapine was discontinued and the patient was referred to a hospice. Two weeks later, her heart failure slowly improved...
May 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28551484/a-common-cancer-in-an-uncommon-location-a-case-report-of-squamous-cell-carcinoma-of-the-nipple
#20
Kelly Dye, Melissa Saucedo, Divya Raju, Nail Aydin
INTRODUCTION: Cutaneous squamous cell carcinoma (SCC) is common however SCC is rarely seen on the nipple, with only ten cases of SCC of the nipple in literature (American Cancer Society, 2015; Scotto et al., 1983; Pendse and O'Connor, 2015; Loveland-Jones et al., 2010; Brookes et al., 2005; Sofos et al., 2013; King and Kremer, 2012; Venkataseshan et al., 1994; Hosaka et al., 2011) [1-9]. CASE: An 80 year old female presenting with a chief complaint of an abnormal lesion on the medial portion of her right nipple areola complex...
May 17, 2017: International Journal of Surgery Case Reports
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