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Vitamine D MI

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https://www.readbyqxmd.com/read/29030554/hdx-reveals-the-conformational-dynamics-of-dna-sequence-specific-vdr-co-activator-interactions
#1
Jie Zheng, Mi Ra Chang, Ryan E Stites, Yong Wang, John B Bruning, Bruce D Pascal, Scott J Novick, Ruben D Garcia-Ordonez, Keith R Stayrook, Michael J Chalmers, Jeffrey A Dodge, Patrick R Griffin
The vitamin D receptor/retinoid X receptor-α heterodimer (VDRRXRα) regulates bone mineralization via transcriptional control of osteocalcin (BGLAP) gene and is the receptor for 1α,25-dihydroxyvitamin D3 (1,25D3). However, supra-physiological levels of 1,25D3 activates the calcium-regulating gene TRPV6 leading to hypercalcemia. An approach to attenuate this adverse effect is to develop selective VDR modulators (VDRMs) that differentially activate BGLAP but not TRPV6. Here we present structural insight for the action of a VDRM compared with agonists by employing hydrogen/deuterium exchange...
October 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28882133/is-a-motivational-interviewing-based-lifestyle-intervention-for-obese-pregnant-women-across-europe-implemented-as-planned-process-evaluation-of-the-dali-study
#2
Judith G M Jelsma, David Simmons, Nina Gobat, Stephen Rollnick, Kinga Blumska, Goele Jans, Sander Galjaard, Gernot Desoye, Rosa Corcoy, Fabiola Juarez, Alexandra Kautzky-Willer, Jürgen Harreiter, Andre van Assche, Roland Devlieger, Dirk Timmerman, David Hill, Peter Damm, Elisabeth R Mathiesen, Ewa Wender-Ożegowska, Agnieszka Zawiejska, Annunziata Lapolla, Maria G Dalfrà, Stefano Del Prato, Alessandra Bertolotto, Fidelma Dunne, Dorte M Jensen, Liselotte Andersen, Frank J Snoek, Mireille N M van Poppel
BACKGROUND: Process evaluation is an essential part of designing and assessing complex interventions. The vitamin D and lifestyle intervention study (DALI) study is testing different strategies to prevent development of gestational diabetes mellitus among European obese pregnant women with a body mass index ≥29 kg/m(2). The intervention includes guidance on physical activity and/or healthy eating by a lifestyle coach trained in motivational interviewing (MI). The aim of this study was to assess the process elements: reach, dose delivered, fidelity and satisfaction and to investigate whether these process elements were associated with changes in gestational weight gain (GWG)...
September 7, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28860784/effect-of-additive-calcium-administration-on-fgf23-levels-in-patients-with-mild-chronic-kidney-disease-treated-with-calcitriol-a-randomized-open-labeled-clinical-trial
#3
Nayoung Han, Su Hyun Hong, Yon Su Kim, Dong Ki Kim, In-Wha Kim, Eunhee Ji, Jung Mi Oh
BACKGROUND: The purpose of the present study was to determine the effect of additional calcium carbonate treatment on fibroblast growth factor 23 (FGF23) levels in patients treated with calcitriol. METHODS: In this randomized, open-labeled, and parallel-group study, a total of 30 patients with early chronic kidney disease (CKD) and vitamin D deficiency were randomly assigned to two groups and received interventions for 8 weeks: 1) a combination of calcium carbonate and calcitriol group; and 2) calcitriol only group...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28766554/campylobacter-jejuni-impairs-sodium-transport-and-epithelial-barrier-function-via-cytokine-release-in-human-colon
#4
R Bücker, S M Krug, V Moos, C Bojarski, M R Schweiger, M Kerick, A Fromm, S Janßen, M Fromm, N A Hering, B Siegmund, T Schneider, C Barmeyer, J D Schulzke
Campylobacter jejuni is the most prevalent cause of foodborne bacterial enteritis worldwide. Patients present with diarrhea and immune responses lead to complications like arthritis and irritable bowel syndrome. Although studies exist in animal and cell models, we aimed at a functional and structural characterization of intestinal dysfunction and the involved regulatory mechanisms in human colon. First, in patients' colonic biopsies, sodium malabsorption was identified as an important diarrheal mechanism resulting from hampered epithelial ion transport via impaired epithelial sodium channel (ENaC) β- and γ-subunit...
August 2, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28765576/visualization-of-synthetic-vascular-smooth-muscle-cells-in-atherosclerotic-carotid-rat-arteries-by-f-18-fdg-pet
#5
Kisoo Pahk, Chanmin Joung, Se-Mi Jung, Hwa Young Song, Ji Yong Park, Jung Woo Byun, Yun-Sang Lee, Jin Chul Paeng, Chunsook Kim, Sungeun Kim, Won-Ki Kim
Synthetic vascular smooth muscle cells (VSMCs) play important roles in atherosclerosis, in-stent restenosis, and transplant vasculopathy. We investigated the synthetic activity of VSMCs in the atherosclerotic carotid artery using (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET). Atherosclerosis was induced in rats by partial ligation of the right carotid artery coupled with an atherogenic diet and vitamin D injections (2 consecutive days, 600,000 IU/day). One month later, rats were imaged by F-18 FDG PET...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28751811/the-association-between-serum-ferritin-and-25-hydroxyvitamin-d-and-metabolic-syndrome-in-korean-women-the-korea-national-health-and-nutrition-examination-survey-2010-2012
#6
Hyun Yoon, Nan Young Bae, Mi Young Gi, Bu Yeon Park, Jeong Min Seong
The present study was conducted to assess the association between serum ferritin and 25-hydroxyvitamin D [25(OH)D] and metabolic syndrome (MetS) in Korean women. The data of a total of 9,256 adults (6,960 women without MetS and 2,296 women with MetS) aged ≥20 years from the Fifth Korean National Health and Nutrition Examination Survey (KNHANES V) (2010-2012) were analyzed. A covariance test adjusted for covariates was performed for serum ferritin levels in relation to vitamin D (vitamin D deficiency, 25(OH)D <10...
July 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/28717806/vitamin-d-status-and-the-risk-of-recurrent-stroke-and-mortality-in-ischemic-stroke-patients-data-from-a-24-month-follow-up-study-in-china
#7
H Qiu, M Wang, D Mi, J Zhao, W Tu, Q Liu
PURPOSE: In this study, we determined serum 25-hydroxyvitamin D [25(OH) D] levels in serum, and investigated their associations with risk of recurrent stroke and mortality in a 24-month follow up study in Chinese patients with first-ever ischemic stroke. METHODS: In this preplanned post hoc analysis, serum levels of 25(OH) D and NIH stroke scale (NIHSS) were measured at the time of admission in a cohort of patients with ischemic stroke. We used logistic regression model to assess the relationship between 25(OH) D levels and risk recurrent stroke or mortality...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28700733/non-invasive-prediction-of-preterm-birth-in-women-with-cervical-insufficiency-or-an-asymptomatic-short-cervix-%C3%A2-25-mm-by-measurement-of-biomarkers-in-the-cervicovaginal-fluid
#8
Ha-Na Yoo, Kyo Hoon Park, Eun Young Jung, Yu Mi Kim, Song Yi Kook, Se Jeong Jeon
OBJECTIVE: To determine whether various proteins in the cervicovaginal fluid (CVF) known to be involved in immune regulation, alone or in combination with clinical risk factors, can predict spontaneous preterm delivery (SPTD) in women with cervical insufficiency or a short cervix (≤25 mm). METHODS: This retrospective cohort study included 62 asymptomatic women with cervical insufficiency (n = 27) or an asymptomatic short cervix (n = 35) at 18-27 weeks. CVF swab samples were taken for assays of vitamin D binding protein (VDBP), interleukin (IL)-8, matrix metalloproteinases (MMP)-9, tissue inhibitor of metalloproteinases (TIMP)-1, and Dickkopf-related protein 3 (DKK3) before cervical examination, and maternal blood was collected for the determination of the C-reactive protein (CRP) level...
2017: PloS One
https://www.readbyqxmd.com/read/28656274/proteomics-of-acute-heart-failure-in-a-rat-post-myocardial-infarction-model
#9
Yichen Guo, Lianqun Cui, Shiliang Jiang, Airong Zhang, Shu Jiang
The aim of the present study was to identify the mechanisms underlying the development of post-myocardial infarction (post-MI) heart failure. The left anterior descending coronary artery of rats was occluded to mimic human ischemic heart disease. Linear Trap Quadropole OrbiTrap mass spectrometry was used to profile the expressions of energy metabolism‑associated and calcium‑binding proteins in the post‑MI and control groups. Using the online Protein Analysis Through Evolutionary Relationships classification system, 78 differentially expressed proteins were identified, including 50 downregulated proteins and 28 upregulated proteins in post‑MI group when compared with the control group...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28645551/association-between-blood-vitamin-d-and-myocardial-infarction-a-meta-analysis-including-observational-studies
#10
REVIEW
Jizhen Huang, Zhiwei Wang, Zhipeng Hu, Wanli Jiang, Bowen Li
BACKGROUND: The association between blood vitamin D levels and the risk of myocardial infarction (MI) is controversial. This meta-analysis aimed to describe the relationship between MI risk and blood vitamin D levels. METHODS: Online databases were searched in PubMed, EMBASE and Web of science till February 2017 for observational studies in relation to reporting the vitamin D levels in MI cases and non-MI controls. The weighted mean difference (WMD) or odds ratio (OR), with 95% confidence interval (CI), were calculated to evaluate the relationship between MI risk and blood vitamin D levels...
June 20, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28562685/gender-difference-in-relationship-between-serum-ferritin-and-25-hydroxyvitamin-d-in-korean-adults
#11
COMPARATIVE STUDY
Jeong Min Seong, Yo Sang Yoon, Kyu Su Lee, Nan Young Bae, Mi Young Gi, Hyun Yoon
BACKGROUND: The present study was conducted to assess the gender difference in the relationship between serum ferritin and 25-hydroxyvitamin D [25(OH)D] in Korean adults. METHODS: A total of 5,147 adults (2,162 men, 1,563 premenopausal women, and 1,422 postmenopausal women) aged ≥ 20 years from the Korean National Health and Nutrition Examination Survey (KNHANES) data (2012) were analyzed. A covariance test adjusted for covariates was performed for serum ferritin levels in relation to vitamin D status (vitamin D deficiency, 25(OH)D < 10...
2017: PloS One
https://www.readbyqxmd.com/read/28523260/combination-therapy-of-raloxifene-and-alendronate-for-treatment-of-osteoporosis-in-elderly-women
#12
Mi Jung Um, Eun A Cho, Hyuk Jung
OBJECTIVES: To evaluate and compare the efficacy and safety of the combination of raloxifene and alendronate with those of monotherapies in elderly women with osteoporosis. METHODS: Sixty-two postmenopausal women (mean age 63.5 ± 0.5 years) attending gynecologic osteoporosis clinics with established osteoporosis were randomly allocated to one of four treatment groups and monitored for 3 years. All patients enrolled in this study, including those in the control group (n = 14), received 1...
April 2017: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/28467451/biochemical-markers-of-bone-turnover-in-benign-paroxysmal-positional-vertigo
#13
Sun Bin Lee, Chang Ho Lee, Young Ju Kim, Hyoung-Mi Kim
OBJECTIVE: Several studies have suggested a possible relationship between recurrent benign paroxysmal positional vertigo (BPPV) and altered calcium homeostasis in the endolymph of the inner ear. The present study aimed to evaluate the association between Ca2+ and vitamin D status and BPPV occurrence as well as the status of bone biochemical markers in osteoporotic patients who were diagnosed with idiopathic BPPV. METHODS: The study included total 132 patients who were referred to our clinic between August 2008 and October 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28467404/utility-of-sun-reactive-skin-typing-and-melanin-index-for-discerning-vitamin-d-deficiency
#14
Arshad T Khalid, Charity G Moore, Christopher Hall, Flora Olabopo, Nigel L Rozario, Michael F Holick, Susan L Greenspan, Kumaravel Rajakumar
BackgroundSkin color, a vitamin D status determinant, can be assessed subjectively by Fitzpatrick sun-reactive skin typing (FST) and objectively by melanin index (MI). FST was validated against MI for discerning vitamin D deficiency (serum 25-hydroxyvitamin D (25(OH)D) <20 ng/ml) in children.MethodsWe measured FST, MI, and serum 25(OH)D in healthy, 8- to 18-year-old children from one of two vitamin D trials. MI from forehead, hand, and upper arm split at the median of the more racially balanced study cohort and FST (I-III vs...
September 2017: Pediatric Research
https://www.readbyqxmd.com/read/28423553/low-vitamin-d-status-is-associated-with-inflammation-in-patients-with-prostate-cancer
#15
Dong-Dong Xie, Yuan-Hua Chen, Shen Xu, Cheng Zhang, Da-Ming Wang, Hua Wang, Lei Chen, Zhi-Hui Zhang, Mi-Zhen Xia, De-Xiang Xu, De-Xin Yu
Vitamin D deficiency has been associated with increased risks of prostate cancer. Nevertheless, the mechanisms remain unclear. The aim of this study was to analyze the association among prostate cancer, vitamin D status and inflammation. Sixty patients with newly diagnosed prostate cancer and 120 age-matched controls were recruited for this study. Vitamin D status was evaluated and serum inflammatory molecules were measured. Serum 25-(OH)D was lower in patients with prostate cancer. Moreover, serum 25(OH)D was lower in patients with severe prostate cancer than patients with mild and moderate prostate cancer...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28394278/vitamin-d-deficiency-among-adults-with-history-of-pulmonary-tuberculosis-in-korea-based-on-a-nationwide-survey
#16
Mi Hyun Joo, Mi Ah Han, Sun Mi Park, Hwan Ho Shin
We investigated the prevalence of vitamin D deficiency among individuals who have a history of tuberculosis (TB) diagnosis in Korea. Using the 5th Korean National Health and Nutrition Examination Survey, we selected 805 individuals with a history of TB diagnosis and 16,049 controls without a history of TB. Vitamin D deficiency was defined as a 25(OH)D level less than 20 ng/mL. Vitamin D deficiency was revealed in 71.7% of the individuals with a history of TB diagnosis and in 72.1% of the controls. Vitamin D deficiency was more likely in women than in men, in people who engaged in other jobs or were unemployed than in people who engaged in skilled agricultural, forestry, and fishery jobs, and in people who walked 3-5 days per week than in people who walked 6-7 days per week...
April 10, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28331532/vitamin-d-a-possible-modifying-factor-linking-obesity-to-vascular-calcification-in-hemodialysis-patients
#17
Jwa-Kyung Kim, Mi Jin Park, Young Rim Song, Hyung Jik Kim, Sung Gyun Kim
BACKGROUND: Obesity is a risk factor for increased cardiovascular disease. Whether vitamin D deficiency modifies this association is unclear. Here, we examined the association of obesity and vitamin D deficiency with vascular calcification score (VCS) in incident end-stage renal disease (ESRD) patients. METHODS: A cross-sectional study was conducted with 213 ESRD patients. Vitamin D deficiency was defined as serum 25-hydroxyvitamin D (25(OH)D) levels below 10 ng/mL, and obesity was defined as a percentage of body fat (PBF) higher than the sex-specific median value in the cohort (>26...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28293927/prevalence-and-risk-factors-of-urticaria-with-a-focus-on-chronic-urticaria-in-children
#18
Seung Jin Lee, Eun Kyo Ha, Hye Mi Jee, Kyung Suk Lee, Seung Won Lee, Mi Ae Kim, Dong Hyun Kim, Young Ho Jung, Youn Ho Sheen, Myong Soon Sung, Man Yong Han
PURPOSE: Limited data is available on the prevalence and risk factors of acute and chronic urticaria in children. Our purpose was to determine the prevalence and identify the risk factors of acute and chronic urticaria in Korean children. METHODS: This population-based study examined 4,076 children (age 4 to 13 years) who were enrolled in the 2015 prospective Seongnam Atopy Project (SAP 2015) in Korea. The parents completed an urticaria questionnaire that included questions regarding the duration, severity, and triggering factors of urticaria...
May 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28245293/protective-effect-of-1%C3%AE-25-dihydroxyvitamin-d3-on-effector-cd4-t-cell-induced-injury-in-human-renal-proximal-tubular-epithelial-cells
#19
Byung Ha Chung, Bo-Mi Kim, Kyoung Chan Doh, Mi-La Cho, Kyoung Woon Kim, Chul Woo Yang
BACKGROUND: The aim of this study was to investigate the protective effect of 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3] on effector CD4+ T cells or on inflammatory cytokine-induced injury in human renal proximal tubular epithelial cells (HRPTEpiC). METHODS: First, we investigated the effect of 1,25(OH)2D3 on CD4+ T cell proliferation. Second, we examined the effect of 1,25(OH)2D3 on inflammatory cytokine secretion or fibrosis in HRPTEpiC induced by inflammatory cytokines or activated CD4+ T cells using ELISA and real-time PCR...
2017: PloS One
https://www.readbyqxmd.com/read/28212289/the-effects-of-myo-inositol-and-b-and-d-vitamin-supplementation-in-the-db-mouse-model-of-gestational-diabetes-mellitus
#20
Jasmine F Plows, Florence Budin, Rebecka A M Andersson, Valerie J Mills, Katherine Mace, Sandra T Davidge, Mark H Vickers, Philip N Baker, Irma Silva-Zolezzi, Joanna L Stanley
Gestational diabetes mellitus (GDM) is a growing concern, affecting an increasing number of pregnant women worldwide. By predisposing both the affected mothers and children to future disease, GDM contributes to an intergenerational cycle of obesity and diabetes. In order to stop this cycle, safe and effective treatments for GDM are required. This study sought to determine the treatment effects of dietary supplementation with myo-inositol (MI) and vitamins B2, B6, B12, and D in a mouse model of GDM (pregnant db/+ dams)...
February 15, 2017: Nutrients
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