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primary dysmenorrhea

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https://www.readbyqxmd.com/read/29452049/model-free-tests-of-equality-in-binary-data-under-an-incomplete-block-design
#1
Kung-Jong Lui, Lixia Zhu
Using Prescott's model-free approach, we develop an asymptotic procedure and an exact procedure for testing equality between treatments with binary responses under an incomplete block crossover design. We employ Monte Carlo simulation and note that these test procedures can not only perform well in small-sample cases but also outperform the corresponding test procedures accounting for only patients with discordant responses published elsewhere. We use the data taken as a part of the crossover trial comparing two different doses of an analgesic with placebo for the relief of primary dysmenorrhea to illustrate the use of test procedures discussed here...
February 16, 2018: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/29434492/sr-16234-a-novel-selective-estrogen-receptor-modulator-for-pain-symptoms-with-endometriosis-an-open-label-clinical-trial
#2
Tasuku Harada, Ikuko Ohta, Yusuke Endo, Hiroshi Sunada, Hisashi Noma, Fuminori Taniguchi
Background: SR-16234 is a selective estrogen receptor modulator (SERM) structurally different from approved SERM and has been reported to have estrogen receptor (ER) α antagonistic activity and strong affinity with a weak partial agonistic activity to ERβ receptor. SR-16234 showed strong inhibitory effects on transplanted endometrial cysts in the endometriosis model of rat and mouse. In this clinical trial, efficacy and safety of SR-16234 have been evaluated in endometriosis patients...
December 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/29417063/the-effect-of-aerobic-exercise-on-primary-dysmenorrhea-a-clinical-trial-study
#3
Zahra Mohebbi Dehnavi, Farzaneh Jafarnejad, Zahra Kamali
INTRODUCTION: Primary dysmenorrhea without pelvic pathology is one of the most common complaints in women's medicine. Primary dysmenorrhea can affect the quality of life of women. Aerobic exercise is one of the ways to reduce the severity of primary dysmenorrhea. The present study aimed to determine the effect of 8 weeks of aerobic exercise on the severity of primary dysmenorrhea. METHODS: This is a clinical trial study performed on 70 students with primary dysmenorrhea in dormitories of Mashhad University of Medical Sciences in 2015...
2018: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/29383891/-effects-of-the-acupoint-catgut-embedding-on-nerve-endocrine-immune-network-in-dysmenorrhea-rats
#4
Pan-Bi Chen, Jing Chen, Jin Cui, Xiao-Fang Yang
OBJECTIVE: To explore the underlying mechanism of acupoint catgut embedding in improving primary dysme-norrhea (PD) in rats based on functional activities of the neuro-endocrine-immune (NEI) network. METHODS: Forty female rats were equally randomized into blank control, PD model, medication, and acupoint catgut embedding groups. The PD model was established by subcutaneous injection of estradiol benzoate (0.5 mg/rat on the 1st and 10th d, and 0.2 mg/rat from 2nd to 9th d) and oxytocin (2 U/rat, i.p...
January 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29379667/the-efficacy-of-laparoscopic-presacral-neurectomy-in-dysmenorrhea-is-it-related-to-the-amount-of-excised-neural-tissue
#5
Murat Api, Ayşen Boza, Mehmet Ceyhan, Ecmel Kaygusuz, Hülya Yavuz, Olus Api
Objective: To assess the correlation between the number of excised neural fibers and degree of pain relief following laparoscopic presacral neurectomy (LPSN). Materials and Methods: In this before and after study, 20 patients with severe midline dysmenorrhea [Visual Analogue Scale (VAS) >80 mm] unresponsive to medical therapy were consecutively enrolled. All patients underwent LPSN. The superior hypogastric plexus was excised and sent for histologic confirmation...
December 2017: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29321498/the-ppi-network-analysis-of-mrna-expression-profile-of-uterus-from-primary-dysmenorrheal-rats
#6
Pei Fan, Qiao-Hui Lin, Ying Guo, Lan-Ling Zhao, He Ning, Meng-Ying Liu, Dong-Qing Wei
To elucidate the mechanisms of molecular regulations underlying primary dysmenorrhea (PD), we used our previously published mRNA expression profile of uterus from PD syndrome rats to construct protein-protein interactions (PPI) network via STRING Interactome. Consequently, 34 subnetworks, including a "continent" (Subnetwork 1) and 33 "islands" (Subnetwork 2-34) were generated. The nodes, with relative expression ratios, were visualized in the PPI networks and their connections were identified. Through path and module exploring in the network, the bridges were found from pathways of cellular response to calcium ion, SMAD protein signal transduction, regulation of transcription from RNA polymerase II promoter in response to stress and muscle stretch that were significantly enriched by the up-regulated mRNAs, to the cascades of cAMP metabolic processes and positive regulation of cyclase activities by the down-regulated ones...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317960/different-effects-of-oral-contraceptive-and-dydrogesterone-treatment-on-oxidative-stress-levels-in-premenopausal-women
#7
Jui-Tung Chen, Kazuhiko Kotani
Background: The aim of the study was to observe the changes in blood oxidative stress levels by oral contraceptive (OC) and/or dydrogesterone (DG) treatment. Methods: A retrospective cohort of 27 premenopausal women with primary dysmenorrhea consisted of the OC treatment group (N = 17) and the DG treatment group (N = 10) by choice of the initial treatment. The OC group included two subgroups: patients with continuous OC treatment (treated for at least 15 months, N = 10) and patients with discontinuous OC treatment (switched to DG treatment after approximately 6 months of initial OC treatment: N = 7)...
February 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29298525/bleeding-pattern-difference-between-levonorgestrel-intrauterine-system-and-copper-intrauterine-devices-inserted-immediately-post-abortion-a-multicenter-prospective-observational-cohort-study-in-chinese-women
#8
Xiaoning Chen, Qianxi Li, Xiaoye Wang, Jing Chen, Wen Lv, Bin Shi, Hong Wang, Jianru Luo, Jian Li
BACKGROUND: To describe the bleeding pattern (primary outcome), side effects, treatment satisfaction and 6 month continuity rates associated with the 52 mg levonorgestrel intrauterine system (LNG-IUS) and the copper intrauterine device (Cu-IUD) inserted immediately after abortion. METHODS: This multicenter, prospective, observational cohort study enrolled healthy women (aged ≥18 years) inserted with LNG-IUS or Cu-IUD immediately after first-trimester surgical abortion and followed up to 6 months...
February 7, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29282583/high-quality-human-preimplantation-embryos-actively-influence-endometrial-stromal-cell-migration
#9
R P Berkhout, C B Lambalk, J Huirne, V Mijatovic, S Repping, G Hamer, S Mastenbroek
PURPOSE: The purpose of this paper is to study whether human preimplantation embryos regulate endometrial stromal cell (hESC) migration. METHODS: Primary hESCs were isolated from fertile patients undergoing hysterectomy for benign conditions (uterine scar niche n = 3, dysmenorrhea n = 2; no hormonal treatment). Migration and proliferation assays were performed by culturing decidualized or non-decidualized hESCs in the presence of embryo conditioned medium (ECM) from high-quality embryos (fragmentation ≤ 20%) or from low-quality embryos (fragmentation > 20%) or in non-conditioned medium from the same dishes (control)...
December 28, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29234428/network-pharmacology-based-approach-to-investigate-the-analgesic-efficacy-and-molecular-targets-of-xuangui-dropping-pill-for-treating-primary-dysmenorrhea
#10
Jihan Huang, Lei Li, Fan Cheung, Ning Wang, Yunfei Li, Zhenyu Fan, Fang Yin, Juan Yang, Rui Gao, Yingchun He, Yibin Feng
This study aimed to evaluate the clinical analgesic efficacy and identify the molecular targets of XGDP for treating primary dysmenorrhea (PD) by a network pharmacology approach. Analysis of pain disappearance rate of XGDP in PD treatment was conducted based on data from phase II and III randomized, double-blind, double-simulation, and positive parallel controlled clinical trials. The bioactive compounds were obtained by the absorption, distribution, metabolism, and excretion processes with oral bioavailability (OB) and drug-likeness (DL) evaluation...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29231558/-impact-of-deqi-on-acupoint-effects-in-patients-with-primary-dysmenorrhea-a-systematic-review-of-randomized-controlled-trials
#11
REVIEW
Yafeng Wang, Junjun Sun, Zhuang Zhang, Huijuan Cao, Pei Wang, Minyi Zhao, Nijuan Hu, Guiwen Wu, Shangqing Hu, Jiang Zhu
The effects of deqi (arrival of qi) on acupoint effects in patients with primary dysmenorrhea (PD) were evaluated.Ten literature databases,including China National Knowledge Infrastructure (CNKI),VIP Database,Wanfang Database,Chinese Biomedical Literature Database (CBM),Cochrane Library CENTRAL,MEDLINE,Embase,AMED, CINAHL Plus,PsycINFO were selected.In addition,5 registers of ongoing trials,the reference lists of included articles and grey literature website OpenGrey were added.The search time was from date of database establishment to August 2016;no restrictions were made on language or status of publication...
July 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231353/-efficacy-of-filiform-needle-manipulation-on-primary-dysmenorrhea-a-systematic-review
#12
Junjun Sun, Yafeng Wang, Zhuang Zhang, Huijuan Cao, Pei Wang, Minyi Zhao, Nijuan Hu, Guiwen Wu, Shangqing Hu, Jiang Zhu
The paper is a systematic review on the efficacy of acupuncture manipulation on primary dysmenorrhea. Ten medical literatures database at home and abroad were retrieved, including CNKI, VIP, CBM, WANFANG, MEDLINE, Cochrane, CENTRAL, CINAHL PLUS, EMBASE, AMED and PsycINFO, as well as 6 clinical trial registration platforms. All of randomized controlled trials (RCTs) on primary dysmenorrhea treated with different acupuncture manipulations were collected. The data were extracted by two persons. Finally, RevMa 5...
August 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29184281/high-intensity-laser-therapy-versus-pulsed-electromagnetic-field-in-the-treatment-of-primary-dysmenorrhea
#13
Ali Abd El-Monsif Thabet, Ahmed Mohamed Elsodany, Kadrya H Battecha, Mansour Abdullah Alshehri, Bassem Refaat
[Purpose] To determine the efficacy of high intensity laser therapy (HILT) versus pulsed electromagnetic field (PEMF) in the treatment of primary dysmenorrhea. [Subjects and Methods] This was a randomized clinical trial that included 52 girls diagnosed with primary dysmenorrhea and who were assigned randomly into two groups of equal numbers. The treatment was three sessions every cycle for three consecutive cycles where group (A) included those participants treated with HILT 15 min/session and group (B) those who were treated with PEMF 30 min/session...
October 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29167518/encoding-of-menstrual-pain-experience-with-theta-oscillations-in-women-with-primary-dysmenorrhea
#14
Pin-Shiuan Lee, Intan Low, Yong-Sheng Chen, Cheng-Hao Tu, Hsiang-Tai Chao, Jen-Chuen Hsieh, Li-Fen Chen
Theta oscillation (4-7 Hz) is well documented for its association with neural processes of memory. Pronounced increase of theta activity is commonly observed in patients with chronic neurogenic pain. However, its association with encoding of pain experience in patients with chronic pain is still unclear. The goal of the present study is to investigate the theta encoding of sensory and emotional information of long-term menstrual pain in women with primary dysmenorrhea (PDM). Forty-six young women with PDM and 46 age-matched control subjects underwent resting-state magnetoencephalography study during menstrual and periovulatory phases...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29155036/effectiveness-of-app-based-self-acupressure-for-women-with-menstrual-pain-compared-to-usual-care-a-randomized-pragmatic-trial
#15
Susanne Blödt, Daniel Pach, Sanna von Eisenhart-Rothe, Fabian Lotz, Stephanie Roll, Katja Icke, Claudia M Witt
BACKGROUND: Primary dysmenorrhea is common among women of reproductive age. Non-steroidal anti-inflammatory drugs and oral contraceptives are effective treatments, although the failure rate is around 20-25%. Therefore additional evidence-based treatments are needed. In recent years, the use of smartphone applications (apps) has increased rapidly and may support individuals in self-management strategies. OBJECTIVE: We aimed to investigate the effectiveness of app-based self-acupressure in women with menstrual pain...
November 15, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29143306/long-term-evaluation-of-painful-symptoms-and-fertility-after-surgery-for-large-rectovaginal-endometriosis-nodule-a-retrospective-study
#16
Nicolas Bourdel, Aurélie Comptour, Paméla Bouchet, Anne-Sophie Gremeau, Jean-Luc Pouly, Karem Slim, Bruno Pereira, Michel Canis
Optimal surgical treatment of rectovaginal endometriosis remains a controversial topic. The objective of this study was to evaluate long term postoperative outcomes after rectal shaving or colorectal resection for rectovaginal endometriosis MATERIAL AND METHODS: 195 patients underwent surgery (172 managed by shaving, 23 by colorectal resection) between January 2000 and June 2013 for rectovaginal endometriosis (>2cm) involving at least the serosa of the rectum. Primary outcome measures were pain and fertility...
November 15, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29135277/somato-visceral-effects-in-the-treatment-of-dysmenorrhea-neuromuscular-manual-therapy-and-standard-pharmacological-treatment
#17
Giovanni Barassi, Rosa Grazia Bellomo, Annamaria Porreca, Piera Attilia Di Felice, Loris Prosperi, Raoul Saggini
OBJECTIVES: This study aims to verify whether neuromuscular therapy (NMT) or pharmacology therapy (PT) is more effective for reducing symptoms in women affected by primary dysmenorrhea and the effects associated with each treatment. DESIGN: A controlled, randomized, single-blind clinical trial within the framework of the chair of physical medicine and rehabilitation of the University "G. d'Annunzio" of Chieti-Pescara. The study was conducted on a sample of 60 women suffering from primary dysmenorrhea...
November 14, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29112942/acupuncture-for-primary-dysmenorrhea-a-meta-analysis-of-randomized-controlled-trials
#18
Tong Liu, Jia-Ni Yu, Bing-Yan Cao, Yuan-Yuan Peng, Yu-Pei Chen, Li Zhang
Context • Primary dysmenorrhea (PD) is one of the most common complaints among young women. Acupuncture has been widely applied as a therapeutic modality in China and abroad for PD; however, the evidence for its benefits is still not convincing. Objective • The study intended to conduct a systematic review of randomized, controlled trials (RCTs) to evaluate the evidence regarding the use of acupuncture in treating PD. Design • The research team retrieved reports for RCTs published in 7 databases from their inception to March 2016, with no language restrictions: PubMed, Medline, Embase, the Cochrane Central Register of Controlled Trials, the Chinese National Knowledge Infrastructure database, the Chinese Biomedical database, and the Wanfang database...
November 7, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29066929/experimental-and-procedural-pain-responses-in-primary-dysmenorrhea-a-systematic-review
#19
REVIEW
Laura A Payne, Andrea J Rapkin, Laura C Seidman, Lonnie K Zeltzer, Jennie Ci Tsao
Primary dysmenorrhea (PD) has been the focus of a number of experimental pain studies. Although a number of reviews exist, few have critically evaluated the existing body of research on PD and experimental and procedural pain. Data from 19 published research articles that include women with PD and responses to an experimental or procedural pain stimulus (or stimuli) suggest that women with PD may have elevated pain reactivity, as compared to women without PD. This pattern appears to be true across different phases of the menstrual cycle...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29037637/effect-of-yoga-on-the-menstrual-pain-physical-fitness-and-quality-of-life-of-young-women-with-primary-dysmenorrhea
#20
Ponlapat Yonglitthipagon, Somruthai Muansiangsai, Wilanee Wongkhumngern, Wanida Donpunha, Raoyrin Chanavirut, Wantana Siritaratiwat, Lukana Mato, Wichai Eungpinichpong, Taweesak Janyacharoen
The aim of the present study was to investigate effect of specially designed yoga program on the menstrual pain, physical fitness, and quality of life (QOL) of non-athlete women with primary dysmenorrhea (PD) aged 18-22 years. Thirty-four volunteers were randomly assigned into control and yoga groups. Menstrual pain, physical fitness, and QOL were evaluated at baseline and at the end of the 12-week study period. The yoga group was asked to practice yoga for 30 min per day, twice a week, for 12 weeks at home, while the control group did not receive any form of exercise over the study period...
October 2017: Journal of Bodywork and Movement Therapies
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