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primary dysmenorrhea

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https://www.readbyqxmd.com/read/28098892/metabolomics-study-on-primary-dysmenorrhea-patients-during-the-luteal-regression-stage-based-on-ultra-performance-liquid-chromatography-coupled-with-quadrupole%C3%A2-time%C3%A2-of%C3%A2-flight-mass-spectrometry
#1
Ling Fang, Caiyun Gu, Xinyu Liu, Jiabin Xie, Zhiguo Hou, Meng Tian, Jia Yin, Aizhu Li, Yubo Li
Primary dysmenorrhea (PD) is a common gynecological disorder which, while not life‑threatening, severely affects the quality of life of women. Most patients with PD suffer ovarian hormone imbalances caused by uterine contraction, which results in dysmenorrhea. PD patients may also suffer from increases in estrogen levels caused by increased levels of prostaglandin synthesis and release during luteal regression and early menstruation. Although PD pathogenesis has been previously reported on, these studies only examined the menstrual period and neglected the importance of the luteal regression stage...
January 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28057931/the-oprm1-a118g-polymorphism-modulates-the-descending-pain-modulatory-system-for-individual-pain-experience-in-young-women-with-primary-dysmenorrhea
#2
Shyh-Yuh Wei, Li-Fen Chen, Ming-Wei Lin, Wei-Chi Li, Intan Low, Ching-Ju Yang, Hsiang-Tai Chao, Jen-Chuen Hsieh
The mu-opioid receptor (OPRM1) A118G polymorphism underpins different pain sensitivity and opioid-analgesic outcome with unclear effect on the descending pain modulatory system (DPMS). Primary dysmenorrhea (PDM), the most prevalent gynecological problem with clear painful and pain free conditions, serves as a good clinical model of spontaneous pain. The objective of this imaging genetics study was therefore to explore if differences in functional connectivity (FC) of the DPMS between the OPRM1 A118G polymorphisms could provide a possible explanation for the differences in pain experience...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28042403/comparison-of-the-effect-of-stretching-exercises-and-mefenamic-acid-on-the-reduction-of-pain-and-menstruation-characteristics-in-primary-dysmenorrhea-a-randomized-clinical-trial
#3
Narges Motahari-Tabari, Marjan Ahmad Shirvani, Abbas Alipour
OBJECTIVES: Dysmenorrhea is a common gynecologic disorder. Although non-steroidal anti-inflammatory drugs are commonly used, due to their side effects and lack of response in some individuals, other approaches such as exercise have been considered. This study compared the effect of stretching exercises and mefenamic acid on the reduction of pain and menstruation characteristics in primary dysmenorrhea. METHODS: In this randomized clinical trial, 122 female students with moderate to severe dysmenorrhea were assessed and were placed in either the exercise or mefenamic acid group...
January 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/27970734/willingness-to-pay-for-primary-dysmenorrhea-health-states
#4
G Ruzsa, L Gulacsi, V Brodszky, M Péntek, E Gradvohl, F Rencz
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27959437/traditional-medicine-sobokchukeo%C3%A2-tang-modulates-the-inflammatory-response-in-adipocytes-and-macrophages
#5
Hoyoung Lee, Eun Hyoung Shim, Myeong Soo Lee, Chang-Seon Myung
Sobokchukeo-Tang (ST) is a well-known formula that is used for treating primary dysmenorrhea caused by blood stasis syndrome (BSS) in Korea and China. The current study investigated the anti‑inflammatory and anti‑adipogenesis effects of ST on adipocytes and macrophages. The anti‑inflammatory efficacy of ST was evaluated in RAW 264.7 cells and differentiated THP‑1 cells. To induce inflammation, the cells were treated with lipopolysaccharide (LPS; 1 µg/ml). Following the induction of inflammation, the levels of proinflammatory cytokines, interleukin‑6 (IL‑6) and tumor necrosis factor‑α (TNF‑α) in the cell supernatant were detected using enzyme‑linked immunosorbent assay...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27936352/prescott-tests-of-equality-in-binary-data-under-a-three-treatment-three-perod-crossover-design
#6
Lixia Zhu, Kung-Jong Lui
Three test procedures accounting for patients with tied responses based on Prescott's ideas are developed for comparing three treatments under a three-period crossover trial in binary data. Monte Carlo simulation is employed to evaluate the performance of these test procedures in a variety of situations. The test procedures proposed here are noted to have power larger than those procedures, which utilize only those patients with un-tied responses. The data taken from a three-period crossover trial comparing two different doses of an analgesic with placebo for the relief of primary dysmenorrhea are used to illustrate the use of the test procedures developed here...
December 9, 2016: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/27930941/evaluation-of-a-new-low-dose-levonorgestrel-intrauterine-contraceptive-system-over-5-years-of-use
#7
Kristina Gemzell-Danielsson, Dan Apter, Sylvia Dermout, Thomas Faustmann, Kimberly Rosen, Thomas Schmelter, Martin Merz, Anita Nelson
OBJECTIVE: To evaluate the efficacy and safety of a new, low-dose levonorgestrel intrauterine contraceptive system (LNG-IUS 12) for up to 5 years of use. STUDY DESIGN: In this Phase III study, 2885 nulliparous and parous women aged 18-35 years were randomized to LNG-IUS 8 or LNG-IUS 12 for 3 years. After 3 years, women using LNG-IUS 12 could continue for up to 2 additional years (5 years total). The primary outcome was occurrence of pregnancy (Pearl Index). Secondary outcomes included safety, bleeding, dysmenorrhea, discontinuations, and user satisfaction...
November 20, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27863617/effectiveness-of-sp6-sanyinjiao-acupressure-for-relief-of-primary-dysmenorrhea-symptoms-a-systematic-review-with-meta-and-sensitivity-analyses
#8
REVIEW
Ukachukwu Okoroafor Abaraogu, Sylvester Emeka Igwe, Chidinma Samantha Tabansi-Ochiogu
We reviewed the available evidence for SP6 (Sanyinjiao) acupressure for the relief of primary dysmenorrhea (PD) symptoms, as well as patients' experiences of this intervention. We searched six relevant databases and gray literature for publications dated up to March 2016. The search yielded 72 potential studies. Six of these studies, contributing a total of 461 participants, were included in this review. The primary outcome was pain intensity. Studies with significant homogeneity were pooled for meta-analysis...
November 2016: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/27832449/abnormal-structure-and-functional-connectivity-of-the-anterior-insula-at-pain-free-periovulation-is-associated-with-perceived-pain-during-menstruation
#9
Wang-Huan Dun, Jing Yang, Ling Yang, Dun Ding, Xue-Ying Ma, Feng-Li Liang, Karen M von Deneen, Shao-Hui Ma, Xiao-Ling Xu, Jixin Liu, Ming Zhang
Neuroimaging studies have demonstrated the critical role of the insula in pain pathways and its close relation with the perceived intensity of nociceptive stimuli. We aimed to identify the structural and functional characteristics of the insula during periovulatory phase in women with primary dysmenorrhea (PDM), and further investigate its association with the intensity of perceived pain during menstruation. Optimized voxel-based morphometry and functional connectivity (FC) analyses were applied by using 3-dimensional T1-weighted and resting functional magnetic resonance imaging (fMRI) in 36 patients at the peri-ovulation phase and 29 age-, education-, and gender-matched healthy controls (HC)...
November 10, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27829860/the-efficacy-of-thai-herbal-prasaplai-formula-for-treatment-of-primary-dysmenorrhea-a-short-term-randomized-controlled-trial
#10
Manmas Vannabhum, Sirikan Poopong, Thanyarat Wongwananuruk, Akarin Nimmannit, Ueamphon Suwannatrai, Chongdee Dangrat, Angkana Apichartvorakit, Suksalin Booranasubkajorn, Tawee Laohapand, Pravit Akaraserenont
This study aims to compare the efficacy of pain relief between a specific Thai herbal Prasaplai formula (PPF) and placebo in patients with primary dysmenorrhea. Forty women with primary dysmenorrhea symptoms were randomized into two groups. The experimental group received PPF capsules 1000 mg orally three times per day before meals for three days starting from the first day of menstruation. The placebo group received placebo as the same dose and time. Average pain intensity from the first day to the third day of cycle significantly decreased in both groups (p < 0...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27821975/the-effect-of-lumbar-pelvic-alignment-and-abdominal-muscle-thickness-on-primary-dysmenorrhea
#11
Moon-Jeong Kim, Il-Hun Baek, Bong-Oh Goo
[Purpose] The purpose of this study was to identify effects of malalignment of the lumbar pelvis, as a passive element, and the thicknesses of abdominal muscles, as active elements, on primary dysmenorrhea. [Subjects and Methods] The subjects were divided into a primary dysmenorrhea group and normal group according to Visual Analogue Scale, and ultimately there were 28 subjects in the dysmenorrhea group and 22 subjects in the normal group. Alignment of the lumbar pelvis was measured by using a Formetric 4D analysis system, and the thicknesses of abdominal muscles were measured by using ultrasound imaging...
October 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27813503/naproxen-paracetamol-and-pamabrom-versus-paracetamol-pyrilamine-and-pamabrom-in-primary-dysmenorrhea-a-randomized-double-blind-clinical-trial
#12
Mario I Ortiz, Gabriela Murguía-Cánovas, Laura C Vargas-López, Rodolfo Silva, Mario González-de la Parra
INTRODUCTION: Dysmenorrhea is caused by the discharge of prostaglandins into the uterine tissue; therefore, non-steroidal anti-inflammatory drugs (NSAIDs) are the established initial therapy for dysmenorrhea. Dysmenorrhea therapy may include the administration of drug monotherapy or combination therapy. However, clinical scientific evidence on the efficacy of medications with two or three drugs combined is scarce or nonexistent. OBJECTIVE: To evaluate and compare the efficacy and safety of two oral fixed-dose combinations for the relief of the symptoms of primary dysmenorrhea among Mexican women...
October 24, 2016: Medwave
https://www.readbyqxmd.com/read/27746387/decoding-the-perception-of-endogenous-pain-from-resting-state-meg
#13
Po-Chih Kuo, Yi-Ti Chen, Yong-Sheng Chen, Li-Fen Chen
Decoding the neural representations of pain is essential to obtaining an objective assessment as well as an understanding of its underlying mechanisms. The complexities involved in the subjective experience of pain make it difficult to obtain a quantitative assessment from the induced spatiotemporal patterns of brain activity of high dimensionality. Most previous studies have investigated the perception of pain by analyzing the amplitude or spatial patterns in the response of the brain to external stimulation...
January 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/27744455/in-vitro-and-in-vivo-effects-of-tumor-suppressor-gene-pten-on-endometriosis-an-experimental-study
#14
Juan Lv, Qiaoying Zhu, Xuemei Jia, Ningzhu Yu, Qian Li
BACKGROUND Endometriosis can cause dysmenorrhea and infertility. Its pathogenesis has not yet been clarified and its treatment continues to pose enormous challenges. The protein tyrosine phosphatase (PTEN) gene is a tumor suppressor gene. The aim of this study was to investigate the role and significance of PTEN protein in the occurrence, development, and treatment of endometriosis through changes in apoptosis rate, cell cycle, and angiogenesis. MATERIAL AND METHODS PTEN was overexpressed and silenced in lentiviral vectors and inserted into primary endometrial cells...
October 16, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27738992/aberrant-default-mode-network-in-patients-with-primary-dysmenorrhea-a-fmri-study
#15
Peng Liu, Yanfei Liu, Geliang Wang, Xuejuan Yang, Lingmin Jin, Jinbo Sun, Wei Qin
Primary dysmenorrhea (PDM), characterized by cramping pain in the lower abdomen, is a common gynecological disorder in women of child-bearing age. An increasing number of neuroimaging studies have emphasized that PDM is associated with functional and structural abnormalities in the regions related to the default mode network (DMN). Based on resting-state functional magnetic resonance imaging (fMRI), the aim of this study was to use amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) to investigate changes of the intrinsic brain activity in the DMN in PDM...
October 13, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27695366/primary-dysmenorrhea-magnitude-associated-risk-factors-and-its-effect-on-academic-performance-evidence-from-female-university-students-in-ethiopia
#16
Solomon Hailemeskel, Asrate Demissie, Nigussie Assefa
BACKGROUND: Primary dysmenorrhea (PD) is the most common gynecologic compliant among adolescent females. There is a wide variation in the estimate of PD, which ranges from 50% to 90%, and the disorder is the most common cause of work and school absenteeism in adolescent females. OBJECTIVE: To assess the prevalence and associated risk factors of PD among female university students and understand its effects on students' academic performance. METHODS: A cross-sectional study was employed in 440 research participants...
2016: International Journal of Women's Health
https://www.readbyqxmd.com/read/27672325/autistic-traits-in-women-with-primary-dysmenorrhea-a-case-control-study
#17
Harun Toy, Arzu Hergüner, Sevcan Şimşek, Sabri Hergüner
OBJECTIVES: Recent studies have shown that women with autism spectrum disorder have higher rates of menstrual problems, including irregular menstrual cycles, unusually painful periods (dysmenorrhea), and excessive menstrual bleeding. In this study, we investigated the autistic traits in female university students with primary dysmenorrhea (PD). METHODS: Seventy females with PD and 70 females without PD were enrolled in the study. The Autism Spectrum Quotient (AQ) was used to measure autistic traits and the Brief Symptom Inventory was used for evaluating anxiety and depression levels...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27651652/efficacy-of-use-of-long-term-low-dose-mifepristone-for-the-treatment-of-fibroids
#18
Anupam Kapur, Ranjeeta Angomchanu, Madhusudan Dey
BACKGROUND: Fibroid or myoma is the commonest reported tumor of uterus, and is one of the important reasons for hysterectomy in our setting. Different drugs are available for medical management of fibroid uterus including mifepristone, a progesterone antagonist. Varying dosage regimen for mifepristone was studied as medical management of fibroid uterus. The aim of the project was to study the effect of mifepristone on the symptoms and size of fibroids, especially using a low-dose regimen for 6 months...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27647013/viburnum-opulus-l-a-remedy-for-the-treatment-of-endometriosis-demonstrated-by-rat-model-of-surgically-induced-endometriosis
#19
Gülçin Saltan, Ipek Süntar, Serkan Ozbilgin, Mert Ilhan, M Ayşe Demirel, Burçin Ergene Oz, Hikmet Keleş, Esra Küpeli Akkol
ETHNOPHARMACOLOGICAL RELEVANCE: Endometriosis is a gynecological disorder characterized by the presence of endometrial tissue outside the uterine cavity. The fruits of Viburnum opulus L. have been used to treat gynecological disorders including primary and secondary dysmenorrhea and ovarian cysts. MATERIALS AND METHODS: Air-dried and powdered fruits of V. opulus were extracted sequentially with n-hexane, ethyl acetate (EtOAc), and methanol (MeOH), respectively for four days...
December 4, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27638894/clinical-implications-of-accessory-fallopian-tube-ostium-in-endometriosis-and-primary-infertility
#20
Nigel Pereira, Isaac Kligman
Several variations in fallopian tube anatomy may be noted during the evaluation of infertility. Some anatomical variants such as accessory tubal ostia are rare. A 31-year-old woman presented to our center with a 2-year history of primary infertility. Given her history of dysmenorrhea, a diagnostic laparoscopy was performed. Laparoscopy revealed a left utero-sacral endometriosis implant, which was resected. Although the left fallopian tube was normal, the right fallopian tube was noted to have two prongs with individual ostia...
July 2016: Women's Health
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