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https://www.readbyqxmd.com/read/28532683/the-essential-oil-from-the-twigs-of-cinnamomum-cassia-presl-inhibits-oxytocin-induced-uterine-contraction-in-vitro-and-in-vivo
#1
Lan Sun, Li-Na Liu, Jia-Chun Li, Yao-Zhong Lv, Shao-Bo Zong, Jun Zhou, Zheng-Zhong Wang, Jun-Ping Kou, Wei Xiao
ETHNOPHARMACOLOGICAL RELEVANCE: The twigs and bark of Cinnamomum cassia Presl (Lauraceae) are widely used in traditional Chinese medicine in the treatment of tumor, abdominal pain, dysmenorrhea, digestive system disease and inflammatory diseases. The aim of this study was to determine the inhibitory effect of the essential oil from the twigs of Cinnamomum cassia Presl (EOCC) on uterine contraction in vitro and in vivo. MATERIALS AND METHODS: The Institute of Cancer Research (ICR) mouse uterine contraction was induced by oxytocin (OT) exposure following estradiol benzoate pretreatment...
May 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28525302/treatment-of-endometriosis-associated-pain-with-elagolix-an-oral-gnrh-antagonist
#2
Hugh S Taylor, Linda C Giudice, Bruce A Lessey, Mauricio S Abrao, Jan Kotarski, David F Archer, Michael P Diamond, Eric Surrey, Neil P Johnson, Nelson B Watts, J Chris Gallagher, James A Simon, Bruce Carr, W Paul Dmowski, Nicholas Leyland, Jean P Rowan, W Rachel Duan, Juki Ng, Brittany Schwefel, James W Thomas, Rita I Jain, Kristof Chwalisz
Background Endometriosis is a chronic, estrogen-dependent condition that causes dysmenorrhea and pelvic pain. Elagolix, an oral, nonpeptide, gonadotropin-releasing hormone (GnRH) antagonist, produced partial to nearly full estrogen suppression in previous studies. Methods We performed two similar, double-blind, randomized, 6-month phase 3 trials (Elaris Endometriosis I and II [EM-I and EM-II]) to evaluate the effects of two doses of elagolix - 150 mg once daily (lower-dose group) and 200 mg twice daily (higher-dose group) - as compared with placebo in women with surgically diagnosed endometriosis and moderate or severe endometriosis-associated pain...
May 19, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28516336/changes-of-functional-connectivity-of-the-anterior-cingulate-cortex-in-women-with-primary-dysmenorrhea
#3
Peng Liu, Yanfei Liu, Geliang Wang, Ru Li, Ying Wei, Yingying Fan, Yang Yu, Demao Deng, Wei Qin
Primary dysmenorrhea (PDM), a common gynecological disorder, is associated with structural and functional alterations in several subregions of the anterior cingulate cortex (ACC). However, systematic functional connectivity of the ACC subregions in PDM has not been clarified. In this study, we used resting-state functional magnetic resonance imaging (fMRI) data from forty-eight PDM patients and thirty-eight matched female healthy controls to investigate the functional connectivity of ACC subregions in PDM. Compared to healthy controls, PDM patients exhibited increased connectivity between the caudal ACC (cACC) and primary somatosensory cortex (SI), between the perigenual ACC (pACC) and caudate, and between the subgenual ACC (sACC) and medial prefrontal cortex (mPFC)...
May 17, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28496369/efficacy-and-safety-of-a-flexible-extended-regimen-of-ethinylestradiol-drospirenone-for-the-treatment-of-dysmenorrhea-a-multicenter-randomized-open-label-active-controlled-study
#4
Mikio Momoeda, Masami Kondo, Joerg Elliesen, Masanobu Yasuda, Shigetomo Yamamoto, Tasuku Harada
BACKGROUND: Dysmenorrhea is a common condition in women, which is characterized by menstrual pain. Low-dose estrogen/progestin combined oral contraceptives have been shown to reduce the severity of dysmenorrhea symptoms, and a 28-day cyclic regimen of ethinylestradiol/drospirenone (28d regimen) is approved for this indication in Japan. AIM: The aim of this study was to assess the safety and efficacy of a flexible extended regimen of ethinylestradiol/drospirenone (flexible regimen) in Japanese women with dysmenorrhea...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28485628/body-composition-and-psychological-improvement-in-healthy-premenopausal-women-assuming-the-oral-contraceptive-containing-micronized-estradiol-e2-and-nomegestrol-acetate-nomac
#5
Manuela Neri, Maria Elena Malune, Valentina Corda, Bruno Piras, Pierina Zedda, Monica Pilloni, Maria Paola Orani, Valerio Vallerino, Gian Benedetto Melis, Anna Maria Paoletti
This observational study was conducted in healthy premenopausal women, who presented themselves for contraceptive advice at the outpatient Family Planning Clinics of the Department of Obstetrics and Gynecology of the University of Cagliari, Hospital-University of Cagliari (Italy). After a screening period of three menstrual cycles, 48 women without contraindications to estroprogestin contraceptives (OCs) were included in the study. The primary purposes of the study were to evaluate whether a 12-month-treatment with the combined OC containing micronized estradiol (1...
May 9, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28480095/the-effect-of-lavender-aromatherapy-on-the-pain-severity-of-primary-dysmenorrhea-a-triple-blind-randomized-clinical-trial
#6
R Nikjou, R Kazemzadeh, M Rostamnegad, S Moshfegi, M Karimollahi, H Salehi
BACKGROUND: Primary dysmenorrhea is the most common complaint in adolescents and adult young women that disturbs their daily life performance. AIM: The current study investigated the effect of lavender aromatherapy on pain severity in primary dysmenorrhea. SUBJECTS AND METHODS: This triple-blind randomized clinical trial was conducted on 200 students of Ardabil University of Medical Sciences, Iran. Subjects were allocated randomly into intervention (lavender) and control (placebo) groups...
July 2016: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/28456617/laparoscopic-excision-versus-ablation-for-endometriosis-associated-pain-updated-systematic-review-and-meta-analysis
#7
REVIEW
Jyotsna Pundir, Kireki Omanwa, Elias Kovoor, Vishal Pundir, Gillian Lancaster, Peter Barton Smith
The aim of the study is to update the evidence on surgical management of endometriosis associated pain - does laparoscopic excision offers any benefits over laparoscopic ablation? This is a systematic review and meta-analysis, where we searched MEDLINE, EMBASE, ISI conference proceedings, ISRCTN, Register and Meta-register for RCTs, WHO trials search portal, Cochrane Library and the 'British Library of electronic theses'. Three RCTs were included which enrolled 335 participants with a sample size per study ranging from 24 to 178 participants...
April 26, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28438280/effect-of-aromatherapy-massage-on-pain-in-primary-dysmenorrhea-a-meta-analysis
#8
Necdet Sut, Hatice Kahyaoglu-Sut
OBJECTIVE: This meta-analysis investigates the effect of aromatherapy massage on pain in primary dysmenorrhea. METHODS: Randomized controlled trials were searched by keywords in several databases (Pubmed, ISI Web of Sciences, and Google Scholar). Six randomized controlled trials that included 362 participants with primary dysmenorrhea, comparing abdominal aromatherapy massage (n = 184) with massage with placebo oils (n = 178), were analyzed in the meta-analysis...
May 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28405780/psychometric-validation-of-the-dysmenorrhea-daily-diary-dysdd-a-patient-reported-outcome-for-dysmenorrhea
#9
Allison M Nguyen, Rob Arbuckle, Tjeerd Korver, Fang Chen, Beverley Taylor, Alice Turnbull, Josephine M Norquist
PURPOSE: The objective of this study was to evaluate the psychometric properties of the Dysmenorrhea Daily Diary (DysDD), an electronic patient-reported outcome, in a sample of 355 women with primary dysmenorrhea enrolled in a phase IIb, multicenter, randomized, partially blinded, placebo-controlled trial for treatment of dysmenorrhea. METHODS: Subjects completed the DysDD over three menstrual cycles, one pre-treatment baseline cycle and two treatment cycles. The DysDD was administered alongside the Menstrual Distress Questionnaire (MDQ), the Short-Form 36 Version 2...
April 12, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28392711/dynamic-abnormalities-of-spontaneous-brain-activity-in-women-with-primary-dysmenorrhea
#10
Lingmin Jin, Xuejuan Yang, Peng Liu, Jinbo Sun, Fei Chen, Ziliang Xu, Wei Qin, Jie Tian
PURPOSE: This study aimed to investigate the regional spontaneous brain activity changes in primary dysmenorrhea (PD) patients in different phases of the menstrual cycle by regional homogeneity (ReHo) analysis. PATIENTS AND METHODS: Thirty-three PD patients and 32 healthy controls (HCs) separately received resting-state functional magnetic resonance imaging during menstrual phase and follicular phase (non-menstrual phase). Cox retrospective symptom scale (RSS), Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were applied to assess related symptoms and emotions...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28383700/measuring-health-related-quality-of-life-in-women-with-endometriosis-comparing-the-clinimetric-properties-of-the-endometriosis-health-profile-5-ehp-5-and-the-euroqol-5d-eq-5d
#11
G Aubry, P Panel, G Thiollier, C Huchon, A Fauconnier
STUDY QUESTION: Which of the Endometriosis Health Profile-5 (EHP-5) and the EuroQol-5D (EQ-5D) is the most efficient to assess quality of life in women suffering from endometriosis? SUMMARY ANSWER: Although EHP-5 and EQ-5D instruments had an excellent responsiveness, EHP-5 has a better discriminative ability than EQ-5 to measure health-related quality of life (HrQoL). WHAT IS KNOWN ALREADY: Proper measurement of HrQoL is important in endometriosis...
June 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28356030/comparison-of-the-effect-of-fish-oil-and-calcium-supplementation-on-treatment-of-primary-dysmenorrhea
#12
Maryam Mehrpooya, Azadeh Eshraghi, Soghra Rabiee, Amir Larki-Harchegani, Sara Ataei
BACKGROUND: Primary dysmenorrhea is common among young girls and childbearing women. Dysmenorrhea is a painful contraction of uterus which happens in the beginning of bleeding or before the menstrual cycle begins. Regarding to the mechanism of calcium in response to hormonal change and the role of fish oil on reducing prostaglandins, we compared the effectiveness of fish-oil and calcium supplementation in treating primarydysmenorrheal. METHODS: This randomized double-blinded clinical trial conducted on women aged 18 to 45 years with moderate to severe primary dysmenorrhea symptoms from January 2015 to March 2015...
March 28, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28292449/the-treatment-of-dysmenorrhea
#13
REVIEW
Sheryl A Ryan
Menstrual disorders and abnormal uterine bleeding are common concerns of young women. Complaints include menses that are: too painful (dysmenorrhea), absent or occur irregularly (amenorrhea or oligoamenorrhea), or prolonged and heavy (menorrhagia, or excessive uterine bleeding). In providing optimal reproductive care, the medical provider must be able to distinguish between normal developmental patterns or symptoms requiring education and reassurance from pathologic conditions requiring prompt assessment and treatment...
April 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/28254679/case-report-laparoscopic-uterovaginal-anastomosis-for-congenital-isolated-cervical-agenesis
#14
Giuseppe Scibilia, Basilio Pecorino, Isabella Pagano, Paolo Scollo
Management of cervical agenesis is a challenge owing to the complexity of the malformation and the difficulty in restoring and preserving fertility. We propose a minimally invasive fertility-sparing surgery for a 17-year-old woman with congenital cervical agenesis and a normal vagina and uterus confirmed by vaginoscopy. The patient was admitted for primary amenorrhea, hematometra, and cyclic pelvic pain. She had undergone previous laparoscopies for ovarian endometriosis. Our surgical approach involved the creation of an isthmus-vaginal anastomosis with a uterovaginal reconnection...
May 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28236018/serum-heme-oxygenase-1-levels-in-patients-with-primary-dysmenorrhea
#15
Ayse Nur Aksoy, Esra Laloglu, Alev Lazoglu Ozkaya, Emsal Pınar Topdagi Yilmaz
PURPOSE: Primary dysmenorrhea effects the life-quality of women negatively. The aim of this study was to evaluate heme oxygenase-1 (HO1) activity together with malondialdehyde (MDA) and nitric oxide (NO) levels in patients with primary dysmenorrhea. METHODS: A total of 28 nulliparous women with the diagnosis of primary dysmenorrhea and 26 healthy controls were included in this study. On the first day of menstruation, all patients underwent ultrasound examination to exclude pelvic pathology and the visual analogue scale was applied to patients...
February 25, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28209488/postoperative-maintenance-levonorgestrel-releasing-intrauterine-system-and-endometrioma-recurrence-a%C3%A2-randomized-controlled-study
#16
Yi-Jen Chen, Teh-Fu Hsu, Ben-Shian Huang, Hsiao-Wen Tsai, Yen-Hou Chang, Peng-Hui Wang
BACKGROUND: According to 3 randomized trials, the levonorgestrel-releasing intrauterine system significantly reduced recurrent endometriosis-related pelvic pain at postoperative year 1. Only a few studies have evaluated the long-term effectiveness of the device for preventing endometrioma recurrence, and the effects of a levonorgestrel-releasing intrauterine system as a maintenance therapy remain unclear. OBJECTIVE: The objective of the study was to evaluate whether a maintenance levonorgestrel-releasing intrauterine system is effective for preventing postoperative endometrioma recurrence...
February 15, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28207540/different-dosages-of-mifepristone-versus-enantone-to-treat-uterine-fibroids-a-multicenter-randomized-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Chongdong Liu, Qi Lu, Hong Qu, Li Geng, Meilu Bian, Minli Huang, Huilan Wang, Youzhong Zhang, Zeqing Wen, Shurong Zheng, Zhenyu Zhang
BACKGROUND: To evaluate the efficacy and safety of 10 mg and 25 mg mifepristone per day compared with 3.75 mg enantone in treating uterine fibroids. METHODS: This is a Multicenter randomized controlled trial. A total of 501 subjects with symptomatic uterine fibroids were enrolled and randomized into the group of 10mg, 25mg mifepristone and 3.75 enantone (with 307, 102 and 92 subjects respectively), with 458 subjects completed the treatment. Three months of daily therapy with oral mifepristone (at a dose of either 10 mg or 25 mg) or once-monthly subcutaneous injections of enantone (at a dose of 3...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28187404/potentized-estrogen-in-homeopathic-treatment-of-endometriosis-associated-pelvic-pain-a-24-week-randomized-double-blind-placebo-controlled-study
#18
Marcus Zulian Teixeira, Sérgio Podgaec, Edmund Chada Baracat
OBJECTIVE: To evaluate the efficacy and safety of potentized estrogen compared to placebo in homeopathic treatment of endometriosis-associated pelvic pain (EAPP). STUDY DESIGN: The present was a 24-week, randomized, double-blind, placebo-controlled trial that included 50 women aged 18-45 years old with diagnosis of deeply infiltrating endometriosis based on magnetic resonance imaging or transvaginal ultrasound after bowel preparation, and score≥5 on a visual analogue scale (VAS: range 0 to 10) for endometriosis-associated pelvic pain...
January 25, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28170396/moxibustion-for-pain-relief-in-patients-with-primary-dysmenorrhea-a-randomized-controlled-trial
#19
Mingxiao Yang, Xiangzhu Chen, Linna Bo, Lixing Lao, Jiao Chen, Siyi Yu, Zheng Yu, Hongzhi Tang, Ling Yi, Xi Wu, Jie Yang, Fanrong Liang
BACKGROUND: Though moxibustion is frequently used to treat primary dysmenorrhea in China, relevant evidence supporting its effectiveness is still scanty. METHODS: This study was a pragmatic randomized, conventional drug controlled, open-labeled clinical trial. After initial screen, 152 eligible participants were averagely randomized to receive two different treatment strategies: Moxibustion and conventional drugs. Participants and practitioners were not blinded in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28162779/progestin-only-pills-may-be-a-better-first-line-treatment-for-endometriosis-than-combined-estrogen-progestin-contraceptive-pills
#20
REVIEW
Robert F Casper
For decades, combined estrogen-progestin oral contraceptive pills (OCPs) have been the first-line treatment for menstrual and pelvic pain associated with endometriosis without any clinical evidence of efficacy. Initial relief provided by OCPs is likely a result of improvement in primary dysmenorrhea. Biologic data and limited clinical evidence support a potential adverse effect of long-term use of OCPs on the progression of endometriosis. In contrast, there is randomized, controlled trial data to support the use of oral progestin-only treatment for pelvic pain associated with endometriosis and for suppressing the anatomic extent of endometriotic lesions...
March 2017: Fertility and Sterility
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