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https://www.readbyqxmd.com/read/29035574/a-6-month-open-label-extension-study-of-vortioxetine-in-pediatric-patients-with-depressive-or-anxiety-disorders
#1
Robert L Findling, Adelaide S Robb, Melissa P DelBello, Michael Huss, Nora K McNamara, Elias H Sarkis, Russell E Scheffer, Lis H Poulsen, Grace Chen, Ole M Lemming, Philippe Auby
OBJECTIVES: In this 6-month open-label extension (OLE) of NCT01491035 (a 14-day, open-label, pharmacokinetic/safety lead-in study), the long-term safety and tolerability of vortioxetine (5-20 mg/day) were investigated in children and adolescents with a DSM-IV-TR™ diagnosis of depressive or anxiety disorder in the United States or Germany. The study also was designed to provide data to inform dose selection and titration in future pediatric studies with vortioxetine. METHODS: Safety evaluations included spontaneously reported adverse events (AEs), the Columbia Suicide Severity Rating Scale (C-SSRS), and the Pediatric Adverse Events Rating Scale (PAERS; clinician administered)...
October 16, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29017868/rates-of-anovulation-in-adolescents-and-young-adults-with-moderate-to-severe-primary-dysmenorrhea-and-those-without-primary-dysmenorrhea
#2
Laura C Seidman, Kathleen M Brennan, Andrea J Rapkin, Laura A Payne
OBJECTIVE: To evaluate rates of presumptive anovulation in eumenorrheic adolescents and young adults with moderate to severe primary dysmenorrhea and those without primary dysmenorrhea. PARTICIPANTS: Thirty-nine adolescents and young adults (ages 16-24) with primary dysmenorrhea and 52 age-matched controls. DESIGN: Participants completed luteinizing hormone surge ovulation predictor test kits. Anovulatory cycles were defined by never receiving a positive result prior to the next menstrual period; participants were grouped as anovulatory if they experienced at least one anovulatory cycle during study participation...
October 7, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28988817/a-systematic-review-and-meta-analysis-of-the-efficacy-of-manipulative-therapy-in-women-with-primary-dysmenorrhea
#3
REVIEW
Ukachukwu Okoroafor Abaraogu, Sylvester Emeka Igwe, Chidinma Samantha Tabansi-Ochiogu, Deborah Onyinyechukwu Duru
OBJECTIVE: To assess the robustness of evidence for the efficacy of manipulative therapy in women with primary dysmenorrhea. METHOD: Seven electronic databases were searched for studies reporting data on manipulative therapy for women with primary dysmenorrhea. The primary and secondary outcomes were pain relief and quality of life, respectively. Quality of eligible studies was assessed using the Physiotherapy Evidence Database (PEDro) guideline. RESULTS: The search yielded 19 citations of which four were systematically reviewed and three eligible for meta-analysis...
August 30, 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/28944048/dysmenorrhea-and-related-disorders
#4
REVIEW
Mariagiulia Bernardi, Lucia Lazzeri, Federica Perelli, Fernando M Reis, Felice Petraglia
Dysmenorrhea is a common symptom secondary to various gynecological disorders, but it is also represented in most women as a primary form of disease. Pain associated with dysmenorrhea is caused by hypersecretion of prostaglandins and an increased uterine contractility. The primary dysmenorrhea is quite frequent in young women and remains with a good prognosis, even though it is associated with low quality of life. The secondary forms of dysmenorrhea are associated with endometriosis and adenomyosis and may represent the key symptom...
2017: F1000Research
https://www.readbyqxmd.com/read/28936905/microwave-diathermy-and-transcutaneous-electrical-nerve-stimulation-effects-in-primary-dysmenorrhea-clinical-trial-protocol
#5
Aline Fernanda Perez Machado, Monica Rodrigues Perracini, Ariane da Cruz Saraiva de Morais, Bruna Oliveira da Silva, Patricia Driusso, Richard Eloin Liebano
The aim of this study will be to analyze the effects of microwave diathermy (MWD) and transcutaneous electrical nerve stimulation (TENS) on primary dysmenorrhea. Eighty eight women, age range 18-44 years, with no previous pregnancy, no practice physical activities, a BMI of ≤29.9 kg/m(2), a regular menstrual cycle and a diagnosis of primary dysmenorrhea, with menstrual pain ranging from mild to severe, will be selected. The participants will be randomized into four groups: MWD and TENS, MWD and placebo TENS, placebo MWD and TENS, and placebo MWD and placebo TENS...
September 22, 2017: Pain Management
https://www.readbyqxmd.com/read/28917360/a-randomized-controlled-clinical-trial-evaluating-quality-of-life-when-using-a-simple-acupressure-protocol-in-women-with-primary-dysmenorrhea
#6
Fatemeh Bazarganipour, Seyed-Abdolvahab Taghavi, Helen Allan, Nazafarin Hosseini, Ahmad Khosravi, Rahimeh Asadi, Shohreh Salari, Raziyeh Dehghani, Zahra Jamshidi, Marziyeh Rezaei, Mansoreh Saberian, Fatemeh Javedan, Zahra Salari, Fahimeh Miri
OBJECTIVE: To evaluate a simple acupressure protocol in LIV3 and LI4 acupoints in women with primary dysmenorrhea. METHODS: This paper reports a randomized, single blinded clinical trial. 90 young women with dysmenorrhea were recruited to three groups to receive 20min acupressure every day in either LIV3 or LI4, or placebo points. Acupressure was timed five days before menstruation for three successive menstrual cycles. On menstruation, each participant completed the Wong Baker faces pain scale, and the quality of life short form -12 (QOL SF-12)...
October 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28906007/intergrated-metabonomic-study-of-the-effects-of-guizhi-fuling-capsule-intervention-on-primary-dysmenorrheal-using-rp-uplc-ms-complementary-with-hilic-uplc-ms-technique
#7
Lang Lang, Zhaorui Meng, Lan Sun, Wei Xiao, Longshan Zhao, Zhili Xiong
Guizhi Fuling capsule (GFC), developed from the traditional Chinese prescription of Guizhi Fuling Wan, has been commonly used for the treatment of primary dysmenorrheal (PD). However, the intervention effective mechanism in vivo has not been well elucidated. In this study, an integrated plasma metabonomic strategy based on RP-UPLC-MS coupled with HILIC-UPLC-MS technique has been developed to investigate the global therapeutic effects and intervention mechanisms of Guizhi Fuling capsule (GFC) on dysmenorrhea rats induced by oxytocin...
September 14, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28885348/effect-of-transcutaneous-electrical-nerve-stimulation-therapy-for-the-treatment-of-primary-dysmenorrheal
#8
RANDOMIZED CONTROLLED TRIAL
Hai-Yan Bai, Hong-Yan Bai, Zhi-Qin Yang
BACKGROUND: This study aimed to investigate the effect and safety of transcutaneous electrical nerve stimulation (TENS) therapy for relieving pain in women with primary dysmenorrhea (PD). METHODS: In this study, 134 participants with PD were randomly divided into the intervention group and the sham group, with 67 participants in each group. Participants in the intervention group received TENS, whereas those in the sham group received sham TENS. The primary outcome was measured by the Numeric Rating Scale (NRS)...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28838645/systematic-screening-and-characterization-of-multiple-constituents-in-guizhi-fuling-capsule-and-metabolic-profiling-of-bioactive-components-in-rats-using-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#9
Yu Zhang, Yezhe Cheng, Zhongbo Liu, Liqin Ding, Tianyi Qiu, Liwei Chai, Feng Qiu, Zhenzhong Wang, Wei Xiao, Longshan Zhao, Xiaohui Chen
Guizhi Fuling capsule (GFC), a prestigious traditional Chinese medicinal (TCM) prescription, is efficiently used to treat primary dysmenorrhea in the clinical practice. It's significant to explore the metabolic fate of multiple components in vivo which are responsible for the pharmacological effects but not fully investigated. A rapid and high-throughput method using ultra performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS/MS) was established for systematic investigation on GFC, including GFC chemical compositions, and their absorption and metabolism in rat plasma, urine, uterus and brain after oral administration of GFC...
September 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28830511/wrist-ankle-acupuncture-waa-for-primary-dysmenorrhea-pd-of-young-females-study-protocol-for-a-randomized-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
Yingfan Chen, Sinan Tian, Jing Tian, Shi Shu
BACKGROUND: Primary dysmenorrhea (PD) is one of the most common health complaints all over the world, specifically among young females. Acupuncture has been employed to relieve the pain-based symptoms and to avoid the side effects of conventional medication, and wrist-ankle acupuncture (WAA) has confirmed analgesic efficacy for various types of pain. The aim of this study is to evaluate the immediate analgesia effect of WAA on PD of young females. METHODS/DESIGN: This study will carry out a randomized parallel controlled single-blind trial to observe the immediate analgesia effect of WAA in PD of young females...
August 22, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28791471/wenjing-decoction-herbal-medicine-for-the-treatment-of-primary-dysmenorrhea-a-systematic-review-and-meta-analysis
#11
REVIEW
Li Gao, Chunhua Jia, Heng Zhang, Cuilan Ma
PURPOSE: Wenjing decoction is a well-accepted traditional Chinese medicine for the treatment of primary dysmenorrhea in East Asia, but its clinical effectiveness and risk have not been adequately assessed. In this paper, we conducted a systematic review and meta-analysis to evaluate the efficacy of Wenjing decoction for the treatment of primary dysmenorrhea. METHODS: Eight databases were used in our research: the Cochrane Library, the Web of Science, PubMed, EMBASE, the Chinese Biomedical Literature Database (CBM), the Chinese National Knowledge Infrastructure (CNKI), the Chinese Scientific Journal Database, and the Wan-fang Database...
August 8, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28767507/bleeding-out-the-quality-adjusted-life-years-evaluating-the-burden-of-primary-dysmenorrhea-using-time-trade-off-and-willingness-to-pay-methods
#12
Fanni Rencz, Márta Péntek, Peep F M Stalmeier, Valentin Brodszky, Gábor Ruzsa, Edina Gradvohl, Petra Baji, László Gulácsi
Primary dysmenorrhea (PD), or painful menstruation in the absence of identified uterine pathology, affects 5 to 9 in every 10 reproductive-aged women. Despite its high prevalence, just a few studies with very small patient numbers have focused on health-related quality of life impairment in PD. We aimed to assess health-related quality of life values for a severe and a mild hypothetical PD health state using 10-year time trade-off and willingness-to-pay methods. In 2015, a nationwide convenience sample of women, aged between 18 and 40 years, was recruited using an Internet-based cross-sectional survey in Hungary...
November 2017: Pain
https://www.readbyqxmd.com/read/28733191/ethnomedicobotanical-study-of-indigenous-knowledge-on-medicinal-plants-used-for-the-treatment-of-reproductive-problems-in-nalbari-district-assam-india
#13
Partha Pradip Adhikari, Simi Talukdar, Ananta Borah
ETHNOPHARMACOLOGICAL RELEVANCE: Reproductive problems are becoming the most predominant health care problems in many countries. World Health Organization (WHO), in 2012, also exemplified maternal illnesses, for instance, birth asphyxia and post birth difficulties are rising at an alarming rate. In addition, not all abnormalities of the human reproductive system have the same origin; the effects of reproductive problems would likely been affected by both male and female. For easy accessibility and affordability, medicinal plants are playing crucial role in primary healthcare services in India and their use is moreover, an integral part of the cultural heritage...
July 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28731958/pain-catastrophizing-and-pain-health-related-quality-of-life-in-endometriosis
#14
Allison E McPeak, Catherine Allaire, Christina Williams, Arianne Albert, Sarka Lisonkova, Paul J Yong
OBJECTIVES: To determine if pain catastrophizing is independently associated with pain health-related quality-of-life in women with endometriosis, independent of potential confounders. METHODS: Analysis of cross-sectional baseline data from a prospective database at a tertiary referral center for endometriosis/pelvic pain. Referrals to the center were recruited between December 2013 to April 2015, with data collected from online patient questionnaires, physical examination, and review of medical records...
July 20, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28703935/the-effect-of-laparoscopic-resection-of-large-niches-in-the-uterine-caesarean-scar-on-symptoms-ultrasound-findings-and-quality-of-life-a-prospective-cohort-study
#15
A J M W Vervoort, J Vissers, W J K Hehenkamp, H A M Brölmann, J A F Huirne
OBJECTIVE: To evaluate the effectiveness of a laparoscopic niche resection on niche related symptoms and/or fertility related problems, ultrasound findings and quality of life. DESIGN: Prospective cohort study. SETTING: University hospital. POPULATION: Women with a large niche (residual myometrium (RM) <3 mm) and complaints of either postmenstrual spotting, dysmenorrhea, intrauterine fluid accumulation and/or difficulties with embryo transfer due to distorted anatomy...
July 13, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28700680/the-role-of-treatment-timing-and-mode-of-stimulation-in-the-treatment-of-primary-dysmenorrhea-with-acupuncture-an-exploratory-randomised-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Mike Armour, Hannah G Dahlen, Xiaoshu Zhu, Cindy Farquhar, Caroline A Smith
OBJECTIVES: We examined the effect of changing treatment timing and the use of manual, electro acupuncture on the symptoms of primary dysmenorrhea. METHODS: A randomised controlled trial was performed with four arms, low frequency manual acupuncture (LF-MA), high frequency manual acupuncture (HF-MA), low frequency electro acupuncture (LF-EA) and high frequency electro acupuncture (HF-EA). A manualised trial protocol was used to allow differentiation and individualized treatment over three months...
2017: PloS One
https://www.readbyqxmd.com/read/28694148/intensity-dependence-of-auditory-evoked-potentials-in-primary-dysmenorrhea
#17
Bingren Zhang, You Xu, Wei He, Jiawei Wang, Hao Chai, Chanchan Shen, Qisha Zhu, Wei Wang
Some studies suggest that women with primary dysmenorrhea have distinct emotional or personality features. For example, they might exaggerate their responses to external stimuli, such as to intensity-increasing auditory stimuli. Fifteen women with primary dysmenorrhea and 15 healthy women were invited to undergo tests of the intensity dependence of auditory evoked potentials (IDAEP), the Functional and Emotional Measure of Dysmenorrhea, and the Plutchik-van Praag Depression Inventory. Study participants with dysmenorrhea showed higher Functional and Emotional scale scores and stronger IDAEP...
July 8, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28683027/pelvic-denervation-procedures-for-dysmenorrhea
#18
Christina Ramirez, Nicole Donnellan
PURPOSE OF REVIEW: Chronic pelvic pain and dysmenorrhea are common conditions affecting reproductive-age women. Surgical pelvic denervation procedures may be a treatment option for women with midline dysmenorrhea, in which medical management is declined by the patient, ineffective at managing symptoms, or medically contraindicated. This review describes the surgical techniques and complications associated with pelvic denervation procedures as well as the current evidence for these procedures in women with primary dysmenorrhea and dysmenorrhea secondary to endometriosis...
August 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28683025/visceral-pain-as-a-triggering-factor-for-fibromyalgia-symptoms-in-comorbid-patients
#19
Raffaele Costantini, Giannapia Affaitati, Ursula Wesselmann, Peter Czakanski, Maria Adele Giamberardino
Fibromyalgia syndrome (FMS) is a central sensitization syndrome; however, peripheral pain sources potentially exacerbate its symptoms of chronic diffuse musculoskeletal pain and hyperalgesia. This prospective study evaluated visceral pain as a possible triggering factor for FMS pain and hyperalgesia in comorbid patients. Women with (1) FMS + irritable bowel syndrome (IBS); (2) FMS + primary dysmenorrhea (Dys); (3) FMS + Dys secondary to endometriosis (Endo); (4) FMS + colon diverticulosis (Div) were compared with FMS-only women, for fibromyalgia pain (number and intensity of episodes and analgesic consumption) over comparable periods and for somatic hyperalgesia (electrical and pressure pain thresholds) in painful (tender points) and control areas (trapezius, deltoid, quadriceps muscles, and overlying subcutis and skin)...
July 3, 2017: Pain
https://www.readbyqxmd.com/read/28666494/quadro-cornuate-uterus
#20
Yasmeen Nauman, Samia Husain
Congenital malformations of the female genital tract are a group of miscellaneous deviations from normal anatomy with diverse spectrum. Mullerian anomalies are thought to be present in 0.5% of female population. Three quarter of women remain asymptomatic, the remaining quarter presents with a variety of symptoms including primary amenorrhea, cyclical pain, severe dysmenorrhea, pelvic mass, ectopic pregnancy, infertility and recurrent miscarriages. The American Fertility Society (AFS) classification has been the most widely used classification for categorizing these abnormalities...
November 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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