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Male fertility

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https://www.readbyqxmd.com/read/29776970/the-e3-ubiquitin-ligase-mib-1-is-necessary-to-form-the-nuclear-halo-in-caenorhabditis-elegans-sperm
#1
Leslie A Herrera, Daniel A Starr
Unlike the classical nuclear envelope with two membranes found in other eukaryotic cells, most nematode sperm nuclei are not encapsulated by membranes. Instead, they are surrounded by a nuclear halo of unknown composition. How the halo is formed and regulated is unknown. We used forward genetics to identify molecular lesions behind three classical fer (fertilization defective) mutations that disrupt the ultrastructure of the Caenorhabditis elegans sperm nuclear halo. We found fer-2 and fer-4 alleles to be nonsense mutations in mib-1...
May 18, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29775925/exposure-to-tris-1-3-dichloro-2-propyl-phosphate-for-two-generations-decreases-fecundity-of-zebrafish-at-environmentally-relevant-concentrations
#2
Yongkang Zhang, Meng Li, Shuying Li, Qiangwei Wang, Guonian Zhu, Guanyong Su, Robert J Letcher, Chunsheng Liu
Previous studies reported that exposure to environmentally relevant concentrations of TDCIPP significantly decreased the number of cumulative eggs in zebrafish, but effects on the quantity of eggs and sperms remained unknown. Therefore, in this study, effects of TDCIPP on yolk diameter, surface morphology of eggs, sperm density and total motility were evaluated. First generation (F0) zebrafish larvae (Danio rerio) were exposed to 0, 50, 500 or 5000 ng/L tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) from 14 days post fertilization (dpf) to 120 dpf...
May 14, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29774805/men-s-preconception-health-a-primary-health-care-viewpoint
#3
Anthony Paul O'Brien, John Hurley, Paul Linsley, Karen Anne McNeil, Richard Fletcher, John Robert Aitken
The purpose of this article is to theoretically explore men's preconception health as a mechanism to enhance fertility, as well as the health and well-being of the subject and his descendants. Premorbid risk factors and behaviors associated with stress, environmental toxins, excessive alcohol consumption, smoking, lack of exercise/obesity, and the use of illicit drugs are all known to affect fecundity. While there are many health clinics available to women, where advice in areas such as postnatal care of the newborn, family planning, and couples fertility is provided, there are few, if any, equivalent health clinics available to men...
May 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29774504/environmental-toxins-and-male-fertility
#4
REVIEW
Mahmoud Mima, David Greenwald, Samuel Ohlander
PURPOSE OF REVIEW: Global industrialization has increased population exposure to environmental toxins. A global decline in sperm quality over the last few decades raises questions about the adverse impact of environmental toxins on male reproductive health. RECENT FINDINGS: Multiple animal- and human-based studies on exposure to environmental toxins suggest a negative impact on semen quality, in terms of sperm concentration, motility, and/or morphology. These toxins may exert estrogenic and/or anti-androgenic effects, which in turn alter the hypothalamic-pituitary-gonadal axis (HPGA), induce sperm DNA damage, or cause sperm epigenetic changes...
May 17, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29774489/the-role-of-lifestyle-in-male-infertility-diet-physical-activity-and-body-habitus
#5
REVIEW
Russell P Hayden, Ryan Flannigan, Peter N Schlegel
PURPOSE OF REVIEW: Increasing attention to primary and secondary prevention of male infertility through modifiable lifestyle factors has gained traction amongst both patients and infertility specialists. In this review, the available evidence of modifiable lifestyle choices, specifically diet, physical activity, and body habitus, are evaluated. RECENT FINDINGS: Studies examining diet, exercise/physical activity, and body habitus are characterized by conflicting conclusions, difficult confounders, and imperfect end points to judge male reproductive potential...
May 17, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29774447/infertility-in-the-aging-male
#6
REVIEW
Daniel J Mazur, Larry I Lipshultz
PURPOSE OF REVIEW: In many countries, the average age of paternity is rising. The negative effect of older age on fertility in women is well documented; however, less is known about the impact of paternal age on fecundity. In this review, we summarize the current knowledge of how paternal age affects semen parameters, reproductive success, and offspring health. RECENT FINDINGS: Contemporary evidence confirms that aged men have worse semen parameters, including overall negative changes in sperm genetics...
May 17, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29774444/male-fertility-preservation
#7
REVIEW
J Abram McBride, Larry I Lipshultz
PURPOSE OF REVIEW: With improvements in cancer treatment outcomes and an increase in cancer survivorship, understanding the importance of fertility preservation options prior to undergoing cancer treatment is essential. Therefore, we review herein the effect of cancer and its treatment on male fertility, the rationale for sperm cryopreservation, options for sperm retrieval, ART outcomes, and experimental options. RECENT FINDINGS: Recent data update fertility outcomes with newer cancer therapies and provide longitudinal insight into survivor paternity with and without fertility preservation...
May 17, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29773976/facing-the-challenges-of-neuropeptide-gene-knockouts-why-do-they-not-inhibit-reproduction-in-adult-teleost-fish
#8
REVIEW
Vance L Trudeau
Genetic manipulation of teleost endocrine systems started with transgenic overexpression of pituitary growth hormone. Such strategies enhance growth and reduce fertility, but the fish still breed. Genome editing using transcription activator-like effector nuclease in zebrafish and medaka has established the role of follicle stimulating hormone for gonadal development and luteinizing hormone for ovulation. Attempts to genetically manipulate the hypophysiotropic neuropeptidergic systems have been less successful...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29773558/genetic-analyses-of-elys-mutations-in-drosophila-show-maternal-effect-lethality-and-interactions-with-nucleoporin-genes
#9
Kazuyuki Hirai, Zhuo Wang, Kohei Miura, Takaaki Hayashi, Takeshi Awasaki, Moe Wada, Yoko Keira, Hiroyuki O Ishikawa, Kyoichi Sawamura
ELYS determines the subcellular localizations of Nucleoporins (Nups) during interphase and mitosis. We made loss-of-function mutations of Elys in Drosophila melanogaster and found that ELYS is dispensable for zygotic viability and male fertility but the maternal supply is necessary for embryonic development. Subsequent to fertilization, mitotic progression of the embryos produced by the mutant females is severely disrupted at the first cleavage division, accompanied by irregular behavior of mitotic centrosomes...
May 18, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29772111/clomiphene-citrate-and-human-chorionic-gonadotropin-are-both-effective-in-restoring-testosterone-in-hypogonadism-a-short-course-randomised-study
#10
Mohamad Habous, Simone Giona, Alaa Tealab, Mohammed Aziz, Ben Williamson, Mohammed Nassar, Zeyad Abdelrahman, Abdallah Remeah, Mohamed Abdelkader, Saleh Binsaleh, Gordon Muir
OBJECTIVES: To compare serum testosterone response and symptom improvement in hypogonadal men in response to treatment by one of three options: clomiphene citrate(CC), human chorionic gonadotropin (hCG), or combination of both therapy. PATIENTS AND METHODS: 282 hypogonadal adult, willing to preserve their fertility, were randomised in three arms treated respectively with: 50 mg of (CC) (n=95), 5000IU of hCG injections twice a week(n=94) or combination of both therapy(n=94)...
May 17, 2018: BJU International
https://www.readbyqxmd.com/read/29769570/in-utero-and-postnatal-exposure-to-high-fat-high-sucrose-diet-suppressed-testis-apoptosis-and-reduced-sperm-count
#11
Jiude Mao, Kathleen A Pennington, Omonseigho O Talton, Laura C Schulz, Miriam Sutovsky, Yan Lin, Peter Sutovsky
Obesity affects male fertility and maternal diabetes affects the offspring sperm epigenome. However, the effects of in utero exposure to maternal glucose intolerance in combination with postnatal high fat, high sucrose (HFHS) diet consumption on offspring spermatogenesis is not clear. The present study was designed to test these effects. One week before and during pregnancy, dams were fed either control or HFHS diet to induce gestational glucose intolerance, and returned to standard diet during lactation. Male offspring from each maternal group were split into control and HFHS-fed groups for eight weeks prior to sacrifice at 11, 19 or 31 weeks of age, and reproductive tissues were harvested for analysis of testicular germ cell apoptosis and sperm output...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769123/obesity-impairs-male-fertility-through-long-term-effects-on-spermatogenesis
#12
Yan-Fei Jia, Qian Feng, Zheng-Yan Ge, Ying Guo, Fang Zhou, Kai-Shu Zhang, Xiao-Wei Wang, Wen-Hong Lu, Xiao-Wei Liang, Yi-Qun Gu
OBJECTIVE: This study aimed to investigate the effect and possible underlying mechanisms of high-fat diet-induced obesity on spermatogenesis in male rats. METHODS: A total of 45 male rats were randomly divided into control (n = 15, normal diet) and obesity groups (n = 30, high-fat diet) and were fed for 16 weeks. Body weight and organ indexes were determined after sacrifice. Indicators of reproductive function, including sperm count, sperm motility, apoptosis of spermatogenic cells, and oxidative stress levels, were measured...
May 16, 2018: BMC Urology
https://www.readbyqxmd.com/read/29766149/alteration-in-catsper-1-and-2-genes-expression-sperm-parameters-and-testis-histology-in-varicocelized-rats
#13
Maryam Zohour Soleimani, Farideh Jalali Mashayekhi, Morteza Mousavi Hasanzade, Maryam Baazm
Background: CatSper gene, a member of cation channel sperm family, has an essential role in sperm motility and male fertility. Following varicocele, sperm parameters especially sperm movement decreases. For this reason, we hypothesized that CatSper gene expression might be reduced after varicocele induction in an animal model. Objective: The aim of this study was to evaluate the expression of CatSper 1 and 2 genes, sperm parameters and testis histology following varicocele induction ...
March 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29766145/basic-and-clinical-genetic-studies-on-male-infertility-in-iran-during-2000-2016-a-review
#14
REVIEW
Sahar Moghbelinejad, Hossein Mozdarania, Pegah Ghoraeian, Reihaneh Asadi
The male factor contributes to 50% of infertility. The cause of male infertility is idiopathic and could be congenital or acquired. Among different factors which are involved in idiopathic male infertility, genetic factors are the most prevalent causes of the disease. Considering, the high prevalence of male infertility in Iran and the importance of genetic factors in the accession of it, in this article we reviewed the various studies which have been published during the last 17 yr on the genetic basis of male infertility in Iran...
March 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29764939/the-importance-of-a-halotyrosine-dehalogenase-for-drosophila-fertility
#15
Abhishek Phatarphekar, Qi Su, Suk Ho Eun, Xin Chen, Steven E Rokita
The ability of iodotyrosine deiodinase to salvage iodide from iodotyrosine has long been recognized as critical for iodide homeostasis and proper thyroid function in vertebrates. The significance of its additional ability to dehalogenate bromo- and chlorotyrosine is less apparent and none of these functions could have been anticipated in invertebrates until recently. Drosophila , as most arthropods, contains a deiodinase homolog encoded by CG6279 , now named condet ( cdt ), with a similar catalytic specificity...
May 15, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29764413/evidence-for-the-use-of-complementary-and-alternative-medicines-during-fertility-treatment-a-scoping-review
#16
Skye A Miner, Stephanie Robins, Yu Jia Zhu, Kathelijne Keeren, Vivian Gu, Suzanne C Read, Phyllis Zelkowitz
BACKGROUND: Complementary and alternative medicines (CAM) are sometimes used by individuals who desire to improve the outcomes of their fertility treatment and/or mental health during fertility treatment. However, there is little comprehensive information available that analyzes various CAM methods across treatment outcomes and includes information that is published in languages other than English. METHOD: This scoping review examines the evidence for 12 different CAM methods used to improve female and male fertility outcomes as well as their association with improving mental health outcomes during fertility treatment...
May 15, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29764212/the-clinical-application-of-single-sperm-based-snp-haplotyping-for-pgd-of-osteogenesis-imperfecta
#17
Linjun Chen, Zhenyu Diao, Zhipeng Xu, Jianjun Zhou, Guijun Yan, Haixiang Sun
Osteogenesis imperfecta (OI) is a genetically heterogeneous disorder, presenting either autosomal dominant, autosomal recessive or X-linked inheritance patterns. The majority of OI cases are autosomal dominant and are caused by heterozygous mutations in either the COL1A1 or COL1A2 gene. In these dominant disorders, allele dropout (ADO) can lead to misdiagnosis in preimplantation genetic diagnosis (PGD). Polymorphic markers linked to the mutated genes have been used to establish haplotypes for identifying ADO and ensuring the accuracy of PGD...
May 15, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29761655/fennel-induces-cytotoxic-effects-against-testicular-germ-cells-in-mice-evidences-for-suppressed-pre-implantation-embryo-development
#18
Aram Minas, Gholamreza Najafi, Ali Shalizar Jalali, Mazdak Razi
Foeniculum vulgare (FVE; fennel) is an aromatic plant belonging to Umbelliferae family, which is widely used in traditional societies because of its different pharmaceutical properties. To uncover the fennel-derived essential oil (FVEO)-induced effects on male reproductive potential, 24 mature male albino mice were divided into, control, 0.37, 0.75, and 1.5 mg kg-1 FVEO-received groups. Following 35 days, the animals were euthanized and the testicular tissue and sperm samples were collected. The histological alterations, tubular differentiation (TDI), spermiogenesis (SPI) indices, apoptosis ratio, and RNA damage of germinal cells were analyzed...
May 15, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29760893/high-levels-of-polyandry-but-limited-evidence-for-multiple-paternity-in-wild-populations-of-the-western-rock-lobster-panulirus-cygnus
#19
Jacqueline Loo, Winn Jason Kennington, Simon de Lestang, Jason How, Jonathan P Evans
Polyandry, where multiple mating by females results in the temporal and spatial overlap of ejaculates from two or more males, is taxonomically widespread and occurs in varying frequencies within and among species. In decapods (crabs, lobsters, crayfish, and prawns), rates of polyandry are likely to be variable, but the extent to which patterns of multiple paternity reflect multiple mating, and thus are shaped by postmating processes that bias fertilization toward one or a subset of mated males, is unclear. Here, we use microsatellite markers to examine the frequency of multiple mating (the presence of spermatophores from two or more males) and patterns of paternity in wild populations of western rock lobster ( Panulirus cygnus )...
May 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29760715/higher-temperature-at-lower-elevation-sites-fails-to-promote-acclimation-or-adaptation-to-heat-stress-during-pollen-germination
#20
Lluvia Flores-Rentería, Amy V Whipple, Gilbert J Benally, Adair Patterson, Brandon Canyon, Catherine A Gehring
High temperatures associated with climate change are expected to be detrimental for aspects of plant reproduction, such as pollen viability. We hypothesized that (1) higher peak temperatures predicted with climate change would have a minimal effect on pollen viability, while high temperatures during pollen germination would negatively affect pollen viability, (2) high temperatures during pollen dispersal would facilitate acclimation to high temperatures during pollen germination, and (3) pollen from populations at sites with warmer average temperatures would be better adapted to high temperature peaks...
2018: Frontiers in Plant Science
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