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https://www.readbyqxmd.com/read/29339528/gonadal-function-in-adult-male-patients-with-congenital-adrenal-hyperplasia
#1
Manon Engels, Katharina Gehrmann, Henrik Falhammar, Emma A Webb, Anna Nordenstrom, Fred Sweep, Paul N Span, Antonius Eduard van Herwaarden, Julia Rohayem, Annette Richter-Unruh, Claire Bouvattier, Birgit Koehler, Barbara B Kortmann, Wiebke Arlt, Nel Roeleveld, Nicole Reisch, Nike Stikkelbroeck, Hedi L Claahsen-van der Grinten
CONTEXT: Current knowledge on gonadal function in Congenital Adrenal Hyperplasia (CAH) is mostly limited to single center/country studies enrolling small patient numbers. Overall data indicate that gonadal function can be compromised in men with CAH. OBJECTIVE: To determine gonadal function in men with CAH within the European "dsd-LIFE" cohort. DESIGN: Cross-sectional clinical outcome study, including retrospective data from medical records...
January 16, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29339164/nanos2-acts-as-an-intrinsic-regulator-of-gonocytes-to-spermatogonia-transition-in-the-murine-testes
#2
Han Pin Pui, Yumiko Saga
In the male mouse embryos, the primordial germ cells colonize the developing testes at E11.5. These resident germ cells termed gonocytes are the predecessors of spermatogonial stem cells (SSCs) and differentiating spermatogonia. Both of which are essential for male fertility where the former maintains the continuity of spermatogenesis and the latter generates pioneering waves of spermatozoa. Therefore the timely initiation of gonocytes-to-spermatogonia transition (GST) is an important process during which the cell fates of gonocytes might be segregated...
January 12, 2018: Mechanisms of Development
https://www.readbyqxmd.com/read/29337356/stabilizing-selection-on-sperm-number-revealed-by-artificial-selection-and-experimental-evolution
#3
Silvia Cattelan, Andrea Di Nisio, Andrea Pilastro
Sperm competition is taxonomically widespread in animals and is usually associated with large sperm production, being the number of sperm in the competing pool the prime predictor of fertilization success. Despite the strong postcopulatory selection acting directionally on sperm production, its genetic variance is often very high. This can be explained by trade-offs between sperm production and traits associated with mate acquisition or survival, that may contribute to generate an overall stabilizing selection...
January 16, 2018: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29336050/sperm-fluorescent-in-situ-hybridisation-study-of-interchromosomal-effect-in-six-tunisian-carriers-of-reciprocal-and-robertsonian-translocations
#4
A Hajlaoui, W Slimani, M Kammoun, A Sallem, S Braham, M Bibi, A Saad, S Mougou-Zerelli
Carriers of structural chromosomal anomalies, translocations and inversions are at increased risk of aneuploid gametes production. Besides the direct effect on the involved chromosomes, these rearrangements might disturb the segregation of other structurally normal chromosomes during meiosis. Such event is known as interchromosomal effect. In this study, six male carriers of translocations, four reciprocals and two Robertsonians, were investigated. In addition, seven fertile men with normal 46,XY karyotypes and normal sperm characteristics were enrolled as a control group...
January 15, 2018: Andrologia
https://www.readbyqxmd.com/read/29336003/prevalence-of-pre-school-children-for-overweight-obesity-in-turkey
#5
Fatih Santas, Gulcan Santas
BACKGROUND: Most of the studies and interventions are targeted to address undernutrition, but childhood obesity has become a silent killer among children. Developing countries, including Turkey, could recognize the importance of the issue now and have begun to discuss the necessity of studies on this subject. Therefore, this study aims to examine the prevalence of obesity among pre-school children in Turkey. METHODS: The data source of this study is the Turkey Demographic and Health Survey (TDHS)-2013...
January 15, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29334961/smoke-alcohol-and-drug-addiction-and-male-fertility
#6
REVIEW
Andrea Sansone, Carla Di Dato, Cristina de Angelis, Davide Menafra, Carlotta Pozza, Rosario Pivonello, Andrea Isidori, Daniele Gianfrilli
In recent decades, the decline in human fertility has become increasingly more worrying: while therapeutic interventions might help, they are vexing for the couple and often burdened with high failure rates and costs. Prevention is the most successful approach to fertility disorders in males and females alike. We performed a literature review on three of the most common unhealthy habits - tobacco, alcohol and drug addiction - and their reported effects on male fertility. Tobacco smoking is remarkably common in most first-world countries; despite a progressive decline in the US, recent reports suggest a prevalence of more than 30% in subjects of reproductive age - a disturbing perspective, given the well-known ill-effects on reproductive and sexual function as well as general health...
January 15, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29334315/interplay-between-p53-and-ink4c-in-spermatogenesis-and-fertility
#7
Hassan Zalzali, Wisam Rabeh, Omar Najjar, Rami Abi Ammar, Mohamad Harajly, Raya Saab
The tumor suppressor p53, and the cyclin-dependent kinase inhibitor Ink4c, have been both implicated in spermatogenesis control. Both p53-/- and Ink4c-/- single knockout male mice are fertile, despite testicular hypertrophy, Leydig cell differentiation defect, and increased sperm count in Ink4c-/- males. To investigate their collaborative roles, we studied p53-/- Ink4c-/- dual knockout animals, and found that male p53-/- Ink4c-/- mice have profoundly reduced fertility. Dual knockout male mice show a marked decrease in sperm count, abnormal sperm morphology and motility, prolongation of spermatozoa proliferation and delay of meiosis entry, and accumulation of DNA damage...
January 15, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29334271/the-safety-of-available-treatments-of-male-hypogonadism-in-organic-and-functional-hypogonadism
#8
G Corona, G Rastrelli, Y Reisman, A Sforza, M Maggi
In the case of primary male hypogonadism (HG), only testosterone (T) replacement therapy (TRT) is possible whereas when the problem is secondary to a pituitary or hypothalamus alteration both T production and fertility can be, theoretically, restored. We here systematically reviewed and discussed the advantages and limits of medications formally approved for the treatment of HG. Areas covered: Data derived from available meta-analyses of placebo controlled randomized trials (RCTs) were considered and analyzed...
January 15, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29334214/quality-of-life-and-its-influencing-factors-of-couples-referred-to-an-infertility-center-in-shiraz-iran
#9
Bahia Namavar Jahromi, Mahsa Mansouri, Sedighe Forouhari, Tahere Poordast, Alireza Salehi
In this article which was published in Int J Fertil Steril, Vol 11, No 4, Jan-Mar 2018, on pages 293-297, the "Duration of tducation (male)" was misspelled in Table 1. The corrected one is "Duration of education (male)". In the sentence "These differences might be related to the use of a fertility-specific instrument (FertiQoL) in the study by Huppelschoten et al. (23) and the current study compared to the general QoL assessment instrument by Chachamovich et al. (24) and Rashidi et al. (15)." Which was at the page of 296 in the discussion section, the word "generic" was corrected in to "general"...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29334202/lifestyle-related-factors-associated-with-reproductive-health-in-couples-seeking-fertility-treatments-results-of-a-pilot-study
#10
Marie-Lou Piché, Véronique Babineau, Julie Robitaille, Émilie Lachance, Stephanie-May Ruchat
Background: The objective of this pilot study was to evaluate the feasibility of conducting a larger prospective cohort study, which will aim at determining the independent contribution of male and female lifestyle-related factors to assisted reproductive technology (ART) success. The study also examined whether couples seeking fertility treatments present lifestyle-related factors that may interfere with their reproductive health. MATERIALS AND METHODS: This prospective pilot study was conducted in a fertility clinic between May 2015 and February 2016...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29330018/testicular-adrenal-rest-tumor-screening-and-fertility-counseling-among-males-with-congenital-adrenal-hyperplasia
#11
Monika Chaudhari, Emilie K Johnson, Daniel DaJusta, Leena Nahata
BACKGROUND: Reduced fertility is a common potential problem among males with congenital adrenal hyperplasia (CAH), with nearly half experiencing impaired sperm production. The major cause of oligo/azoospermia in CAH is testicular adrenal rest tumors (TARTs). Studies indicate that ultrasound screening for TARTs should begin during childhood, yet it remains unclear whether boys with CAH are routinely screened for TARTs and/or counseled about infertility risk and potential interventions such as fertility testing and/or preservation...
December 21, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29329387/patients-with-acephalic-spermatozoa-syndrome-linked-to-sun5-mutations-have-a-favorable-pregnancy-outcome-from-icsi
#12
Jianzheng Fang, Jingjing Zhang, Fuxi Zhu, Xiaoyu Yang, Yugui Cui, Jiayin Liu
STUDY QUESTION: Are Sad1 and UNC84 domain containing 5 (SUN5) mutations associated with the outcomes of ICSI in patients with acephalic spermatozoa syndrome (ASS)? SUMMARY ANSWER: Despite highly abnormal sperm morphology, ASS patients with SUN5 mutations have a favorable pregnancy outcome following ICSI. WHAT IS KNOWN ALREADY: ASS is a rare cause of infertility characterized by the production of a majority of headless spermatozoa, along with a small proportion of intact spermatozoa with an abnormal head-tail junction...
January 10, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29324596/preterm-delivery-and-low-birth-weight-among-neonates-conceived-with-intracytoplasmic-sperm-injection-compared-with-conventional-in-vitro-fertilization
#13
Sanaz Keyhan, Tracy Truong, Yi-Ju Li, Tia Jackson-Bey, Jennifer L Eaton
OBJECTIVE: To examine the prevalence of prematurity and low birth weight (LBW) among singletons conceived with intracytoplasmic sperm injection (ICSI) compared with those conceived with conventional in vitro fertilization (IVF). METHODS: Using the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System, we conducted a retrospective cohort study of women undergoing a first, fresh autologous ICSI or conventional IVF cycle from 2004 to 2013. Singleton live births were included in the analysis...
January 9, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29323738/an-epididymis-specific-secretory-protein-clpsl2-critically-regulates-sperm-motility-acrosomal-integrity-and-male-fertility
#14
Xiaosheng Lu, Fei Ding, Zizhen Lian, Lei Chen, Zuowu Cao, Yiqing Guan, Ran Chen, Dongqing Cai, Yanhong Yu
The epididymis performs an important role in the maturation of spermatozoa including their acquisition of progressive motility and fertilizing ability. However, the molecular mechanisms that govern these maturational events are still poorly defined. Here we report that Clpsl2, a novel colipase homology, is exclusively expressed in the caupt epididymis and conserved in mammalian. Clpsl2 was secreted into the lumen and covered the acrosome region and principal piece of spermatozoa tail. And during epididymal transit, the binding rate between Clpsl2 protein and the spermatozoa gradually decreased...
January 11, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29321918/reproductive-management-in-dairy-cows-the-future
#15
REVIEW
Mark A Crowe, Miel Hostens, Geert Opsomer
Background: Drivers of change in dairy herd health management include the significant increase in herd/farm size, quota removal (within Europe) and the increase in technologies to aid in dairy cow reproductive management. Main body: There are a number of key areas for improving fertility management these include: i) handling of substantial volumes of data, ii) genetic selection (including improved phenotypes for use in breeding programmes), iii) nutritional management (including transition cow management), iv) control of infectious disease, v) reproductive management (and automated systems to improve reproductive management), vi) ovulation / oestrous synchronisation, vii) rapid diagnostics of reproductive status, and viii) management of male fertility...
2018: Irish Veterinary Journal
https://www.readbyqxmd.com/read/29321367/drosophila-pallidosa-whether-a-separate-species-or-a-light-form-of-d-ananassae
#16
B N Singh, Roshni Singh
Drosophila pallidosa belongs to the D. ananassae complex, which includes a total of 10 species. Earlier D. pallidosa was known as light form of D. ananassae but later it was described as a new species, sibling of D. ananassae. Both these terms, light form and sibling species were used by Futch. This makes the taxonomic status of D. pallidosa confusing. In this review we have tried to understand the actual status of this sibling species pair. Considering the similarities and dissimilarities, we suggest that D...
December 2017: Journal of Genetics
https://www.readbyqxmd.com/read/29320903/air-pollution-and-human-sperm-sex-ratio
#17
Michał Radwan, Emila Dziewirska, Paweł Radwan, Lucjusz Jakubowski, Wojciech Hanke, Joanna Jurewicz
The present study was designed to address the hypothesis that exposure to specific air pollutants may impact human sperm Y:X chromosome ratio. The study population consisted of 195 men who were attending an infertility clinic for diagnostic purposes and who had normal semen concentration of 15-300 mln/ml (WHO, 2010). Participants represented a subset of men in a multicenter parent study conducted in Poland to evaluate environmental factors and male fertility. Participants were interviewed and provided a semen sample...
January 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29319911/genomic-islands-of-differentiation-in-two-songbird-species-reveal-candidate-genes-for-hybrid-female-sterility
#18
Libor Mořkovský, Václav Janoušek, Jiří Reif, Jakub Rídl, Jan Pačes, Lukáš Choleva, Karel Janko, Michael W Nachman, Radka Reifová
Hybrid sterility is a common first step in the evolution of postzygotic reproductive isolation. According to Haldane's Rule it affects predominantly the heterogametic sex. While the genetic basis of hybrid male sterility in organisms with heterogametic males has been studied for decades, the genetic basis of hybrid female sterility in organisms with heterogametic females has received much less attention. We investigated the genetic basis of reproductive isolation in two closely related avian species, the Common Nightingale (Luscinia megarhynchos) and the Thrush Nightingale (L...
January 10, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29317647/investigation-of-piwi-interacting-rna-pathway-genes-role-in-idiopathic-non-obstructive-azoospermia
#19
Zeeba Kamaliyan, Sara Pouriamanesh, Mohsen Soosanabadi, Milad Gholami, Reza Mirfakhraie
Genes involved in piwi-interacting RNAs (piRNAs) pathway have an essential role in spermatogenesis. HIWI and TDRD proteins are critical for piRNA biogenesis and function. Therefore, Mutations and polymorphisms in HIWI and TDRD genes may play role in male infertility. The aim of the present study was to investigate the role of HIWI2 rs508485 (T>C) and HIWI3 rs11703684 (C>T) polymorphisms and mutational analysis of TDRD5 gene in idiopathic non-obstructive azoospermia in a case-control study including 226 non-obstructive azoospermia patients and 200 fertile males...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311626/lipopolysaccharide-and-lipotheicoic-acid-differentially-modulate-epididymal-cytokine-and-chemokine-profiles-and-sperm-parameters-in-experimental-acute-epididymitis
#20
Erick J R Silva, Camilla M Ribeiro, André F M Mirim, Alan A S Silva, Renata M Romano, Jorge Hallak, Maria Christina W Avellar
Bacterial infections are the most prevalent etiological factors of epididymitis, a commonly diagnosed inflammatory disease in the investigation of male infertility factors. The influence of early pathogenic mechanisms at play during bacterial epididymitis on reproductive outcomes is little understood. We report here that experimental epididymitis induced in rats by Gram-negative (LPS) and Gram-positive (LTA) bacterial products resulted in differential patterns of acute inflammation in the cauda epididymis. LPS elicited a strong inflammatory reaction, as reflected by upregulation of levels of mRNA for seven inflammatory mediators (Il1b, Tnf, Il6, Ifng, Il10, Nos2 and Nfkbia), and tissue concentration of six cytokines/chemokines (IL1A, IL1B, IL6, IL10, CXCL2 and CCL2) within the first 24 h post-treatment...
January 8, 2018: Scientific Reports
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