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Y-X Wang, Y-Q Li, Y Chen, C-H Zhang, Z Dong, Z Wang, S-N Zhao, C-H Li, P-L Zhang
OBJECTIVE: Orolingual angioedema (OA) is a rare clinical complication with a potentially fatal risk that occurs after the intravenous application of alteplase (rt-PA) in patients with acute ischemic stroke. The purpose of this work is to investigate the related factors of OA in patients with acute ischemic stroke after the administration of intravenous thrombolytic therapy, to improve the predictive ability of OA during intravenous thrombolytic therapy, and to reduce the prevalence of complications...
March 2018: European Review for Medical and Pharmacological Sciences
Shiyong Gao, Huixin Tan, Lang Lang, Jing Bai, Yubin Ji
α-solanine is one of the major components of Solanum nigrum Linn., the fruits of which are used in China for food. In the present study, α-solanine was selected to assess the inhibition of arylamine N-acetyltransferase (NAT) activity and mRNA expression of NAT and kinetics in HepG2 cells. NAT activity was examined by HPLC. The double-reciprocal plot was contrived to yield a regression equation to calculate Km and Vmax. NAT mRNA expression was determined by PCR. The results revealed that α-solanine could significantly decrease NAT activity in intact HepG2 cells or the cytoplasm...
May 2018: Oncology Reports
Stephany Tandy-Connor, Jenna Guiltinan, Kate Krempely, Holly LaDuca, Patrick Reineke, Stephanie Gutierrez, Phillip Gray, Brigette Tippin Davis
PurposeThere is increasing demand from the public for direct-to-consumer (DTC) genetic tests, and the US Food and Drug Administration limits the type of health-related claims DTC tests can market. Some DTC companies provide raw genotyping data to customers if requested, and these raw data may include variants occurring in genes recommended by the American College of Medical Genetics and Genomics to be reported as incidental/secondary findings. The purpose of this study was to review the outcome of requests for clinical confirmation of DTC results that were received by our laboratory and to analyze variant classification concordance...
March 22, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Hyuck Jun Jung, Myoung Jin Ho, Sungwan Ahn, Young Taek Han, Myung Joo Kang
The oral bioavailability of entecavir (EV), an anti-viral agent commonly prescribed to treat hepatitis B infections, is drastically reduced under a post-prandial state. This is primarily due to its low permeability in the gastrointestinal tract. To reduce the food effect on the intestinal absorption of the nucleotide analogue, four lipidic prodrugs were synthesized via the esterification of the primary alcohol of EV with fatty acids (hexanoic acid, octanoic acid, decanoic acid, and dodecanoic acid). EV-3-dodecanoate (or EV-C12) exhibited high solubility in a fed state simulated intestinal fluid (78...
March 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Cuiping Yu, Yue Cha, Fan Wu, Xianbing Xu, Ming Du
In this study, the effects of limited hydrolysis and/or high-pressure homogenization (HPH) treatment in acid conditions on the functional properties of oyster protein isolates (OPI) were studied. Protein solubility, surface hydrophobicity, particle size distribution, zeta potential, foaming, and emulsifying properties were evaluated. The results showed that acid treatment led to the dissociation and unfolding of OPI. Subsequent treatment such as limited proteolysis, HPH, and their combination remarkably improved the functional properties of OPI...
March 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Dario Donno, Maria Gabriella Mellano, Marta De Biaggi, Isidoro Riondato, Ernest Naivonirina Rakotoniaina, Gabriele Loris Beccaro
European bird cherry ( Prunus padus L.) has been known since the Middle Ages for its medical/food use and high health-promoting value. This study aimed to assess the potential of these fruits as a source of bioactive compounds through the characterization of its physicochemical traits, nutraceutical properties, phytochemical composition via HPLC fingerprint, and antioxidant capacity. Fully ripened fruits of Prunus padus L. (Colorata cv) were collected in mid-July 2017 in Chieri, north-western Italy. The TPC (194...
March 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Jing Tao, Yu-Qin Zhao, Chang-Feng Chi, Bin Wang
In the experiment, crude proteins from spotless smoothhound ( Mustelus griseus ), cartilages were isolated by HCl-Guanidine buffer, and its hydrolysate was prepared using trypsin at pH 8.0, 40 °C with a total enzyme dose of 2.5%. Subsequently, three antioxidant peptides were purified from the hydrolysate using membrane ultrafiltration, anion-exchange chromatography, gel filtration chromatography, and reverse phase high-performance liquid chromatography. The amino acid sequences of isolated peptides were identified as Gly-Ala-Glu-Arg-Pro (MCPE-A); Gly-Glu-Arg-Glu-Ala-Asn-Val-Met (MCPE-B); and Ala-Glu-Val-Gly (MCPE-C) with molecular weights of 528...
March 22, 2018: Marine Drugs
Laura Johnson, Zoi Toumpakari, Angeliki Papadaki
An energy-dense, high-fat, low-fibre dietary pattern has been prospectively associated with the development of obesity in childhood but is population-specific, which limits translating the pattern into interventions. We explored the generalisability and correlates of this obesogenic dietary pattern in the UK National Diet and Nutrition Survey (NDNS) for the first time. Data came from participants ( n = 4636 children and n = 4738 adults) with 4-day food diaries in NDNS 2008-2014. Reduced rank regression was applied to 51 food groups to explain variation in energy density, fibre and fat intake...
March 22, 2018: Nutrients
Betul Yilmaz, Arzu Zeynep Karabay
NaB, the metabolite of cinnamon and sodium salt of benzoic acid is a commonly used food and beverage preservative. Various studies have investigated NaB for its effects on different cellular models. However, the effects of NaB on cancer cell viability signaling is substantially unknown. In this study, the effects of NaB on viability parameters and NFκB, one of the most important regulators in apoptosis, were examined in HCT116 colon cancer cells. Cell culture, light microscopy, spectrophotometry, flow cytometry, and western blot were used as methods to determine cell viability, caspase-3 activity, NFκB, Bcl-xl, Bim, and PARP proteins, respectively...
March 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Andreza De Paula Santos Epifânio, Karla Pereira Balbino, Monica De Paula Jorge, Sonia M R Ribeiro, Ana Vládia Bandeira Moreira, Jerusa Maria Oliveira, Leandro Licursi Oliveira, Helen Hermana Miranda Hermsdorff
INTRODUCTION: Oxidative stress markers such as nitric oxide (NO) have been investigated in hemodialysis (HD). OBJECTIVE: Evaluate the association of NO variation with adiposity indicators, metabolic, inflammatory and oxidative stress markers in individuals to HD. METHODS: Cross-sectional study with 85 subjects on HD treatment (≥ 18 years). The clinical-nutritional status was evaluated through subjective global assessment modified (SGAm), anthropometric measurements and body composition...
January 10, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Zenaida Vazquez-Ruiz, Carmen De la Fuente-Arrillaga, Maira Bes-Rastrollo, Itziar Zazpe, Susana Santiago, Cristina Razquin, Estefanía Toledo, Miguel Ángel Martinez-Gonzalez
INTRODUCTION AND OBJECTIVES: Our aim was to prospectively evaluate the association between egg consumption and dyslipidemia in a Mediterranean cohort. METHODS: We followed-up 13,104 Spanish university graduates for a mean period of 8 years. Dietary habits at baseline were assessed using a validated semi-quantitative 136-item food-frequency questionnaire. Self-reported blood concentrations of total cholesterol, high-density lipoproteins cholesterol (HDL-c) and triglycerides were evaluated according to categories of egg consumption after 6 and 8 years of follow-up...
January 12, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Caroline Pinho R Andrade, Mileda L T Portugal, Ellén De Sousa Paz, Paula A Freitas, Ana Filomena C S Daltro, Kaluce G S Almondes, Carla Soraya C Maia, Ariclecio Cunha de Oliveira
OBJECTIVE: The aim of this study was to analyze the influence of liver transplantation in food intake and nutritional status of severe cirrhotic patients. METHODS: The sample consisted of 23 patients who underwent liver transplantation. Three 24-hour dietary recall were applied and anthropometric measurements were collected before and three months after transplantation. The consumption of macronutrients and fat soluble vitamins were also evaluated. The anthropometric data evaluated were body mass index, abdominal circumference, percentage of adequacy of arm circumference, triceps skinfold thickness and arm muscle circumference...
January 16, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Danielle Cristina Guimarães da Silva, Kelly Aparecida da Cunha, Wellington Segheto, Vanessa Guimarães Reis, France Araújo Coelho, Sílvia Helena O Morais, Milene Cristine Pessoa, Giana Zarbato Longo
INTRODUCTION: The identification of risk or protective behavioral patterns associated with abdominal adiposity may aid in prevention and health promotion measures. OBJECTIVE: To identify and to associate behavioral patterns of risk and protection to abdominal adiposity in adults in a Brazilian city. MATERIAL AND METHODS: A population-based cross-sectional study was carried out in Viçosa, Brazil, with 1,226 adults of both sexes. Information on social-demographic characteristics, food intake, level of physical activity, alcohol consumption and smoking were collected by using a questionnaire...
February 13, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Bruno Santos Assis, Jairza Maria Barreto-Medeiros Jairza, Jamile Almeida Lopes, Ana Karla Carneiro Roriz, Adriana Lima Melo, Agatha Previdell, Rita De Cássia Aquino, Lilian Barbosa Ramos
OBJECTIVE: The aim of this study was to evaluate the ingestion of micronutrients in elderly living in nursing homes. METHODS: This is a cross-sectional study, conducted with 216 individuals of both sexes, age equal or greater than 60 years, living in nursing homes for elderly in Salvador, Bahia, Brazil. Direct weighing of the food was used to get food intake, and prevalence of inadequacy was obtained using the software Multiple Source Method (MSM) and evaluated by estimated average requirement (EAR)...
February 13, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Lauren Vogel
No abstract text is available yet for this article.
February 20, 2018: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
Hui Wang, Tao Feng, Ning Hai Zhuang, Min Zhi Xu, Ran Ye, Min Sun
This review attempts to visualize the actual impact of starch nanoparticle-based materials in different areas. In recent patent databases, starch nanoparticles showed the importance of this material, as well as relevant topics concerning the applications of starch nanoparticles in different domains. Because starch is environmentally friendly, starch nanoparticles are suggested as one of the promising biomaterials for novel utilization in foods, papermaking, medicines as well as various composites. In this review, the most common techniques for starch nanoparticles preparation were found to be acid and enzymatic procedures, ultrasonic treatment, combination of hydrolysis and Ultrasonic treatment, high pressure homogenization, enzymatic hydrolysis and recrystallization and emulsion-crosslinking...
March 20, 2018: Recent Patents on Food, Nutrition & Agriculture
Michael F Brown, Marie E Saxon, Kelsey A Heslin
Rats searched for food in a situation that allowed them to determine which locations contained food after searching a small number of them, but not which of the baited locations contained more-preferred food rather than a less-preferred food. During some experimental trials, the latter information was available from the choices of model rats making choices together with the subject rats, because some of the model rats tended to choose the locations baited with more-preferred food. On the surface, the results suggest that social influence specified the locations of more-preferred food to the subject rats...
March 21, 2018: Learning & Behavior
Juan Cruz Montañez, María A Arribére, Andrea Rizzo, Marina Arcagni, Linda Campbell, Sergio Ribeiro Guevara
Zinc (Zn) bioaccumulation and trophic transfer were analyzed in the food web of Lake Nahuel Huapi, a deep, unpolluted ultraoligotrophic system in North Patagonia. Benthic macroinvertebrates, plankton, and native and introduced fish were collected at three sites. The effect of pyroclastic inputs on Zn levels in lacustrine food webs was assessed by studying the impact of the eruption of Puyehue-Cordón Caulle volcanic complex (PCCVC) in 2011, by performing three sampling campaigns immediately before and after the PCCVC eruption, and after 2 years of recovery of the ecosystem...
March 21, 2018: Environmental Science and Pollution Research International
Yuanli Luo, Daiwen Dong, Yu Su, Xuyi Wang, Yumei Peng, Jiang Peng, Changyong Zhou
Mustard clubroot, caused by Plasmodiophora brassicae, is a serious disease that affects Brassica juncea var. tumida Tsen, a mustard plant that is the raw material for a traditional fermented food manufactured in Chongqing, China. In our laboratory, we screened the antagonistic bacteria Zhihengliuella aestuarii against P. brassicae. To better understand the biocontrol mechanism, three transcriptome analyses of B. juncea var. tumida Tsen were conducted using Illumina HiSeq 4000, one from B. juncea only inoculated with P...
March 22, 2018: Functional & Integrative Genomics
Edward Yu, Frank B Hu
PURPOSE OF REVIEW: To examine recent literature on dairy products, dairy fatty acids, and cardiometabolic disease. Primary questions of interest include what unique challenges researchers face when investigating dairy products/biomarkers, whether one should consume dairy to reduce disease risk, whether dairy fatty acids may be beneficial for health, and whether one should prefer low- or high-fat dairy products. RECENT FINDINGS: Dairy composes about 10% of the calories in a typical American diet, about half of that coming from fluid milk, half coming from cheese, and small amounts from yogurt...
March 21, 2018: Current Atherosclerosis Reports
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