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Nervous central system lymphoma

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https://www.readbyqxmd.com/read/28543967/central-nervous-system-involvement-of-primary-cutaneous-diffuse-large-b-cell-lymphoma-leg-type-13-cases
#1
E Gardette, A Maraval, F Brunet-Possenti, G Quereux, H Beltraminelli, I Templier, J Hodel, E Scherman, E Durot, M Bagot, A Pham-Ledard, F Grange, M Beylot-Barry, S Ingen-Housz-Oro
Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) is an aggressive primary cutaneous B-cell lymphoma affecting older people.(1) Rituximab (RTX) combined with polychemotherapy (RTX-PCT) has improved survival but relapses are frequent.(2) Central nervous system (CNS) involvement is rare and poorly described. This article is protected by copyright. All rights reserved.
May 23, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28541571/childhood-adolescent-and-young-adult-cancer-incidence-in-japan-in-2009-2011
#2
Kota Katanoda, Akiko Shibata, Tomohiro Matsuda, Megumi Hori, Kayo Nakata, Yoshitaka Narita, Chitose Ogawa, Wataru Munakata, Akira Kawai, Hiroshi Nishimoto
Little is known about cancer incidence among children and youths in Japan. We aimed to describe cancer incidence in Japan focusing on childhood, adolescence and young adulthood (AYA). Cancer incidence data were obtained from the Monitoring of Cancer Incidence in Japan project. For the 2009-2011 incidence, the data were collected from 40 prefectures, of which data from 27 prefectures meeting quality standards were analyzed (population coverage: 38.6%). Cancers diagnosed in 0-39 years of age were classified according to the International Classification of Childhood Cancer (version 3)...
May 24, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28535175/parental-age-and-risk-of-pediatric-cancer-in-the-offspring-a-population-based-record-linkage-study-in-california
#3
Rong Wang, Catherine Metayer, Libby Morimoto, Joseph L Wiemels, Andrew T DeWan, Alice Kang, Xiaomei Ma
By linking birth records and cancer registry data from California, we conducted a population-based study with 23,419 cases and 87,593 matched controls born in 1978-2009 to investigate the relation of parental age to risk of pediatric cancer. Compared to children born to mothers aged 20-24 years, those born to mothers in older age groups had a 13% to 36% increased risk of pediatric cancer, the odds ratio (OR) for each 5-year maternal age increase was 1.06 (95% confidence interval[CI]: 1.04,1.09). For cancer diagnosed at 0-14 and 15-19 years, the OR for each 5-year increase in maternal age was1...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28532172/cranio-spinal-rosai-dorfman-disease-case-series-and-literature-review
#4
Shashank S Joshi, Shilpa Joshi, Girish Muzumdar, Keki E Turel, Rajan M Shah, Indoo Ammbulkar, Muhammad Masood Hussain, Kishor A Choudhari
Rosai-Dorfman disease (RDD) is a rare condition similar to lymphomas, presenting with cervical lymphadenopathy in young adults. Extra-nodal involvement is relatively common but involvement of the central nervous system (CNS) is rare. Cranial RDD presents with symptoms of raised intracranial pressure, focal or generalised seizures, while spinal RDD presents with pain, peripheral neurological deficits and radiculopathy. In contrast to other similar neoplastic or degenerative conditions affecting the CNS, RDD is a benign, non-infective, granulomatous disorder...
May 22, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28526811/proteomic-analysis-of-cerebrospinal-fluid-from-children-with-central-nervous-system-tumors-identifies-candidate-proteins-relating-to-tumor-metastatic-spread
#5
Filippo Spreafico, Italia Bongarzone, Sara Pizzamiglio, Ruben Magni, Elena Taverna, Maida De Bortoli, Chiara M Ciniselli, Elena Barzanò, Veronica Biassoni, Alessandra Luchini, Lance A Liotta, Weidong Zhou, Michele Signore, Paolo Verderio, Maura Massimino
Central nervous system (CNS) tumors are the most common solid tumors in childhood. Since the sensitivity of combined cerebrospinal fluid (CSF) cytology and radiological neuroimaging in detecting meningeal metastases remains relatively low, we sought to characterize the CSF proteome of patients with CSF tumors to identify biomarkers predictive of metastatic spread. CSF samples from 27 children with brain tumors and 13 controls (extra-CNS non-Hodgkin lymphoma) were processed using core-shell hydrogel nanoparticles, and analyzed with reverse-phase liquid chromatography/electrospray tandem mass spectrometry (LC-MS/MS)...
May 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28526178/late-onset-progressive-multifocal-leukoencephalopathy-in-hodgkin-lymphoma
#6
Whitley W Aamodt, James E Siegler, Angela N Viaene, Michael N Rubenstein
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease resulting from infection of oligodendrocytes in the central nervous system with John Cunningham virus. Although PML is commonly diagnosed in immunocompromised patients with human immunodeficiency virus, it can also arise in other immunodeficient states. In this report, we present an unusual case of PML occurring 40years after chemoradiation therapy for Hodgkin lymphoma in a patient with normal total lymphocyte counts on annual surveillance...
May 16, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28521029/soluble-taci-and-soluble-bcma-as-biomarkers-in-primary-central-nervous-system-lymphoma
#7
Franziska S Thaler, Sarah A Laurent, Marion Huber, Matthias Mulazzani, Martin Dreyling, Uwe Ködel, Tania Kümpfel, Andreas Straube, Edgar Meinl, Louisa von Baumgarten
Background: B-cell survival is regulated through interactions of B-cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) with their receptors transmembrane activator and CAML interactor (TACI) and B-cell maturation antigen (BCMA). We evaluated the diagnostic potential of soluble TACI (sTACI) and soluble BCMA (sBCMA) in cerebrospinal fluid (CSF) and serum as biomarkers in primary CNS lymphoma (PCNSL). Methods: CSF (n=176) and serum samples (n=105) from patients with clinically or radiologically suspected PCNSL as well as from control patients were collected prospectively...
May 17, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28516080/cutaneous-anaplastic-large-t-cell-lymphoma-with-invasion-of-the-central-nervous-system-a-case-report
#8
Hyun-Nam Seo, Jin-Ho Seo, Cheol-Young Lee, Jihye Song, Jong-Hyun Kim, Hyun-Woo Kim
Anaplastic large T-cell lymphoma (ALCL) encompasses different clinical entities that can be aggressive or localized. Scalp anaplastic lymphoma kinase (ALK)-negative ALCL is considered a localized lymphoma, and usually extends to the regional lymph nodes; intracranial invasion is rare. A 74-year-old woman was diagnosed with scalp ALK-negative ALCL, but did not exhibit invasion of the lymph nodes. Computed tomography and magnetic resonance imaging revealed intracranial masses with bony erosions. We treated the patient using CHOP chemotherapy and achieved short-term regression of the scalp and intracranial lesions...
April 2017: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/28515410/differentiating-between-central-nervous-system-lymphoma-and-high-grade-glioma-using-dynamic-susceptibility-contrast-and-dynamic-contrast-enhanced-mr-imaging-with-histogram-analysis
#9
Kazuhiro Murayama, Yuya Nishiyama, Yuichi Hirose, Masato Abe, Shigeharu Ohyu, Ayako Ninomiya, Takashi Fukuba, Kazuhiro Katada, Hiroshi Toyama
PURPOSE: We evaluated the diagnostic performance of histogram analysis of data from a combination of dynamic susceptibility contrast (DSC)-magnetic resonance imaging (MRI) and dynamic contrast-enhanced (DCE)-MRI for quantitative differentiation between central nervous system lymphoma (CNSL) and high-grade glioma (HGG), with the aim of identifying useful perfusion parameters as objective radiological markers for differentiating between them. METHODS: Eight lesions with CNSLs and 15 with HGGs who underwent MRI examination, including DCE and DSC-MRI, were enrolled in our retrospective study...
May 18, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28514747/diagnostic-value-of-using-18f-fdg-pet-and-pet-ct-in-immunocompetent-patients-with-primary-central-nervous-system-lymphoma-a-systematic-review-and-meta-analysis
#10
Yaru Zou, Jianjing Tong, Haiyan Leng, Jingwei Jiang, Meng Pan, Zi Chen
BACKGROUND: 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and PET/CT have become two of the most powerful tools for malignant lymphoma exploration, but their diagnostic role in primary central nervous system lymphoma (PCNSL) is still disputed. The purpose of our study is to identify the usefulness of 18F-FDG PET and PET/CT for detecting PCNSL. RESULTS: A total of 129 patients, obtained from eight eligible studies, were included for this systematic review and meta-analysis...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28508176/the-prognostic-role-of-cd68-and-foxp3-expression-in-patients-with-primary-central-nervous-system-lymphoma
#11
Hyunsoo Cho, Se Hoon Kim, Soo-Jeong Kim, Jong Hee Chang, Woo Ick Yang, Chang-Ok Suh, June-Won Cheong, Yu Ri Kim, Jung Yeon Lee, Ji Eun Jang, Yundeok Kim, Yoo Hong Min, Jin Seok Kim
The prognostic role of CD68 and FoxP3 in primary central nervous system lymphoma (PCNSL) has not been evaluated. Thus, we examined the prognostic significance of CD68 and FoxP3 expression in tumor samples of 76 newly diagnosed immunocompetent PCNSL patients. All patients were treated initially with high-dose methotrexate (HD-MTX)-based chemotherapy, and 16 (21.1%) patients received upfront autologous stem cell transplantation (ASCT) consolidation. High expression of CD68 (>55 cells/high-power field) or FoxP3 (>15 cells/high-power field) was observed in 10 patients, respectively...
May 15, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28507804/hla-dependent-immune-escape-mechanisms-in-b-cell-lymphomas-implications-for-immune-checkpoint-inhibitor-therapy
#12
Marcel Nijland, Rianne N Veenstra, Lydia Visser, Chuanhui Xu, Kushi Kushekhar, Gustaaf W van Imhoff, Philip M Kluin, Anke van den Berg, Arjan Diepstra
Antigen presentation by tumor cells in the context of Human Leukocyte Antigen (HLA) is generally considered to be a prerequisite for effective immune checkpoint inhibitor therapy. We evaluated cell surface HLA class I, HLA class II and cytoplasmic HLA-DM staining by immunohistochemistry (IHC) in 389 classical Hodgkin lymphomas (cHL), 22 nodular lymphocyte predominant Hodgkin lymphomas (NLPHL), 137 diffuse large B-cell lymphomas (DLBCL), 39 primary central nervous system lymphomas (PCNSL) and 19 testicular lymphomas...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28496180/clinicopathologic-significance-of-myd88-l265p-mutation-in-diffuse-large-b-cell-lymphoma-a-meta-analysis
#13
Ju-Han Lee, Hoiseon Jeong, Jung-Woo Choi, HwaEun Oh, Young-Sik Kim
The precise clinicopathologic significance of myeloid differentiation primary response gene (MYD88) L265P mutation in diffuse large B-cell lymphomas (DLBCLs) remains elusive. To investigate the frequency and clinicopathologic significance of the MYD88 L265P mutation in DLBCLs, we conducted a meta-analysis of 40 published studies on 2736 DLBCL patients. We collected relevant published research findings identified using the PubMed and Embase databases. The effect sizes of outcome parameters were calculated using a random-effects model...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28489744/diagnostic-accuracy-of-spect-pet-and-mrs-for-primary-central-nervous-system-lymphoma-in-hiv-patients-a-systematic-review-and-meta-analysis
#14
Mo Yang, James Sun, Harrison X Bai, Yongguang Tao, Xiangqi Tang, Lisa J States, Zishu Zhang, Jianhua Zhou, Michael D Farwell, Paul Zhang, Bo Xiao, Li Yang
BACKGROUND: We performed a systematic review and meta-analysis to assess the roles of SPECT, PET, and MRS in distinguishing primary central nervous system lymphoma (PCNSL) from other focal brain lesions (FBLs) in human immunodeficiency virus (HIV)-infected patients. METHODS: PubMed, Scopus, and Medline were systematically searched for eligible studies from 1980 to 2016. Two authors extracted characteristics of patients and their lesions using predefined criteria...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28488621/tumefactive-acute-disseminated-encephalomyelitis
#15
Sunil Pradhan, Surjyaprakash S Choudhury, Animesh Das
Tumefactive demyelinating lesions are tumour-like presentations of acute demyelinating lesions. They have been described with multiple sclerosis only and not with other varieties of acquired demyelination like acute disseminated encephalomyelitis (ADEM). The uncertainty about the diagnosis at the onset of the disease in tumefactive ADEM makes it important that the physicians should be aware of this entity. Various radiological similarities with more sinister lesions like central nervous system gliomas or lymphomas may lead to this confusion...
May 2017: Neurology India
https://www.readbyqxmd.com/read/28486495/long-term-inpatient-disease-burden-in-the-adult-life-after-childhood-cancer-in-scandinavia-aliccs-study-a-cohort-study-of-21-297-childhood-cancer-survivors
#16
Sofie de Fine Licht, Kathrine Rugbjerg, Thorgerdur Gudmundsdottir, Trine G Bonnesen, Peter Haubjerg Asdahl, Anna Sällfors Holmqvist, Laura Madanat-Harjuoja, Laufey Tryggvadottir, Finn Wesenberg, Henrik Hasle, Jeanette F Winther, Jørgen H Olsen
BACKGROUND: Survivors of childhood cancer are at increased risk for a wide range of late effects. However, no large population-based studies have included the whole range of somatic diagnoses including subgroup diagnoses and all main types of childhood cancers. Therefore, we aimed to provide the most detailed overview of the long-term risk of hospitalisation in survivors of childhood cancer. METHODS AND FINDINGS: From the national cancer registers of Denmark, Finland, Iceland, and Sweden, we identified 21,297 5-year survivors of childhood cancer diagnosed with cancer before the age of 20 years in the periods 1943-2008 in Denmark, 1971-2008 in Finland, 1955-2008 in Iceland, and 1958-2008 in Sweden...
May 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28484158/adult-t-cell-leukemia-lymphoma-complicated-by-takotsubo-cardiomyopathy-and-htlv-1-associated-myelopathy-after-treatment-with-the-anti-ccr4-antibody-mogamulizumab
#17
Satoshi Yamanaka, Kazutaka Nakayama, Hayato Tamai, Masanori Sakamaki, Koiti Inokuchi
Adult T-cell leukemia-lymphoma (ATL) caused by human T-lymphotropic virus type 1 (HTLV-1) is generally associated with poor prognosis. The anti-CCR4 antibody mogamulizumab is one of the options for refractory or relapsed ATL. Mogamulizumab is intravenously administered as a single agent at a dose of 1.0 mg/kg once a week for 8 weeks. The overall response rate is reported to be 50%. Reported common adverse events after administration of mogamulizumab are leukocytopenia, infusion reaction, and skin rash. Although rare, mogamulizumab-associated cardiomyopathy has also been reported...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28482717/radiation-therapy-improves-survival-in-patients-with-testicular-diffuse-large-b-cell-lymphoma
#18
Jennifer C Ho, Bouthaina S Dabaja, Sarah A Milgrom, Grace L Smith, Jay P Reddy, Ali Mazloom, Ken H Young, Lijuan Deng, L Jeffrey Medeiros, Wenli Dong, Pamela K Allen, Therese Y Andraos, Nathan H Fowler, Loretta J Nastoupil, Yasuhiro Oki, Luis E Fayad, Francesco Turturro, Sattva S Neelapu, Jason Westin, Fredrick B Hagemeister, Maria Alma Rodriguez, Chelsea C Pinnix
In 120 Stage I-IV testicular diffuse large B-cell lymphoma (DLBCL) patients treated from 1964 to 2015, we assessed the benefits of prophylactic contralateral testicular radiation (RT) and prophylactic central nervous system (CNS) therapy on overall, progression free, testicular relapse free, and CNS relapse free survival (OS, PFS, TRFS, and CRFS, respectively). Seventy percent of patients received RT, 53% received anthracyclines and rituximab (modern therapy), and 61% received CNS prophylaxis. On univariate analysis RT was associated with improved TRFS, PFS, and trended toward improved OS...
May 9, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28480291/fatal-eastern-equine-encephalitis-in-a-patient-on-maintenance-rituximab-a-case-report
#19
Isaac H Solomon, Pedro D S C Ciarlini, Sandro Santagata, Asim A Ahmed, Umberto De Girolami, Sashank Prasad, Shibani S Mukerji
A 63-year-old woman on rituximab maintenance for follicular lymphoma presented with headaches, vomiting, and fever, and was diagnosed with eastern equine encephalomyelitis by cerebrospinal fluid polymerase chain reaction. Eastern equine encephalomyelitis immunoglobulin (Ig)G/IgM remained negative due to rituximab treatment, and magnetic resonance imaging showed minimal abnormalities, making this a diagnostically challenging case. Despite therapy with intravenous Ig, the patient rapidly declined and died on hospital day 12...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28476199/primary-central-nervous-system-lymphoma-as-a-neurosurgical-problem
#20
REVIEW
Dariusz Szczepanek, Ewa Wąsik-Szczepanek, Filip Stoma, Bożena Sokołowska, Tomasz Trojanowski
Primary central nervous system lymphoma (PCNSL) comprises around 3-5% of primary central nervous system (CNS) tumours and around 1% of all non-Hodgkin lymphoma (NHL). Diffuse large B-cell lymphoma (DLBCL) is the most common histological type. High effectiveness of chemo- and radiotherapy for PCNSL regrettably does not eliminate significant risks of recurrence for CNS tumours. That results in higher interest in other treatment options, including surgical procedures. PCNSL remains in the scope of interest for many specialists and neurosurgeons seem to play a more important role...
April 19, 2017: Neurologia i Neurochirurgia Polska
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