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Near-infrared spectroscopy

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https://www.readbyqxmd.com/read/28925890/the-use-of-hemodynamic-and-cerebral-monitoring-to-study-pharmacodynamics-in-neonates
#1
A Smits, L Thewissen, A Dereymaeker, E Dempsey, A Caicedo, Gunnar Naulaers
BACKGROUND: Drugs acting on the cardiovascular and central nervous system often display relatively fast clinical responses, which may differ in neonates compared to children and adults. Introduction of bedside monitoring tools might be of additional value in the pharmacodynamic (PD) assessment of such drugs in neonates. METHODS: We aim to provide an overview of the frequently used monitoring tools to assess drug effects on the hemodynamic status as well as the cerebral circulation, oxygenation and cerebral metabolism in neonates...
September 18, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28925151/-construction-of-nirs-based-total-quality-control-system-for-compound-ejiao-oral-liquid-and-relative-thinking
#2
Yan Zhang, Lu Zhang, Shou-Sheng Tian, Xiang-Shan Zhou, Wen-Long Li, Hai-Bin Qu
In this paper, near infrared spectroscopy (NIRS)-based total quality control system of compound Ejiao oral liquid is introduced briefly, including the quality control of raw traditional Chinese medicine (TCM) materials, monitoring and control of the extract and the alkaline precipitation technics, and also the inspection of finished products in both open bottle and non-opening modes. By analyzing and summing up the significance and difficulties, several important problems in the practical applications of NIRS technology are proposed, which will provide references for the similar studies of other TCM products...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925150/-construction-of-nirs-based-process-analytical-system-for-production-of-salvianolic-acid-for-injection-and-relative-discussion
#3
Lei Zhang, Hong-Shui Yue, Ai-Chun Ju, Zheng-Liang Ye
Currently, near infrared spectroscopy (NIRS) has been considered as an efficient tool for achieving process analytical technology(PAT) in the manufacture of traditional Chinese medicine (TCM) products. In this article, the NIRS based process analytical system for the production of salvianolic acid for injection was introduced. The design of the process analytical system was described in detail, including the selection of monitored processes and testing mode, and potential risks that should be avoided. Moreover, the development of relative technologies was also presented, which contained the establishment of the monitoring methods for the elution of polyamide resin and macroporous resin chromatography processes, as well as the rapid analysis method for finished products...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925149/-research-on-modeling-method-to-analyze-lonicerae-japonicae-flos-extraction-process-with-online-mems-nir-based-on-two-types-of-error-detection-theory
#4
Chen-Zhao Du, Zhi-Sheng Wu, Na Zhao, Zheng Zhou, Xin-Yuan Shi, Yan-Jiang Qiao
To establish a rapid quantitative analysis method for online monitoring of chlorogenic acid in aqueous solution of Lonicera Japonica Flos extraction by using micro-electromechanical near infrared spectroscopy (MEMS-NIR). High performance liquid chromatography(HPLC) was used as reference method.Kennard-Stone (K-S) algorithm was used to divide sample sets, and partial least square(PLS) regression was adopted to establish the multivariate analysis model between the HPLC analysis contents and NIR spectra. The synergy interval partial least squares (SiPLS) was used to selected modeling waveband to establish PLS models...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925146/-rapid-monitoring-five-components-of-ethanol-precipitation-process-of-shenzhiling-oral-solution-using-near-infrared-spectroscopy
#5
Tong-Tong Li, Tian Hu, Lei Nie, Li-Xuan Zang, Ying-Zi Zeng, Heng-Chang Zang
To develop a method for the rapid monitoring of five components during the alcohol precipitation process of Shenzhiling oral solution using near infrared spectroscopy(NIRS).The contents of five components detemined by high performance liquid chromatography(HPLC) were used as the reference values, and the NIRS based partial least square regression(PLSR) models were used to monitor the concentrations of paeoniflorin, albiflorin, liquiritin, cinnamic acid and glycyrrhizic acid during the alcohol precipitation process of Shenzhiling oral solution, which were optimized and verified through comparing of different spectral pre-processing and variables selection methods...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925145/-research-on-optimal-modeling-strategy-for-licorice-extraction-process-based-on-near-infrared-spectroscopy-technology
#6
Hai-Xia Wang, Tong-Chuan Suo, He-Shui Yu, Zheng Li
The manufacture of traditional Chinese medicine (TCM) products is always accompanied by processing complex raw materials and real-time monitoring of the manufacturing process. In this study, we investigated different modeling strategies for the extraction process of licorice. Near-infrared spectra associate with the extraction time was used to detemine the states of the extraction processes. Three modeling approaches, i.e., principal component analysis (PCA), partial least squares regression (PLSR) and parallel factor analysis-PLSR (PARAFAC-PLSR), were adopted for the prediction of the real-time status of the process...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925144/-induction-and-analysis-for-nir-features-of-frequently-used-mineral-traditional-chinese-medicines
#7
Long Chen, Ming-Yang Yuan, Ke-Li Chen
In order to provide theoretical basis for the rapid identification of mineral traditional Chinese medicines(TCM) with near infrared (NIR)diffuse reflectance spectroscopy, Characteristic NIR spectra of 51 kinds of mineral TCMs were generalized and compared on the basis of the previous research, and the characteristic spectral bands were determined and analyzed by referring to mineralogical and geological literatures. It turned out that the NIR features of mineral TCMs were mainly at 8 000-4 000 cm ⁻¹ wavebands, which can be assigned as the absorption of water, -OH and[CO3 ²⁻] and so on...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925143/-exploration-of-rapidly-determining-quality-of-traditional-chinese-medicines-by-nir-spectroscopy-based-on-internet-sharing-mode
#8
Li-Jun Ni, Shao-Rong Luan, Li-Guo Zhang
Because of the numerous varieties of herbal species and active ingredients in the traditional Chinese medicine(TCM),the traditional methods employed could hardly satisfy the current determination requirements of TCM.The present work proposed an idea to realize rapid determination of the quality of TCM based on near infrared(NIR)spectroscopy and internet sharing mode. Low cost and portable multi-source composite spectrometer was invented by our group for in-site fast measurement of spectra of TCM samples. The database could be set up by sharing spectra and quality detection data of TCM samples among TCM enterprises based on the internet platform...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925142/-research-progress-on-method-validation-of-near-infrared-spectroscopy-in-quantitative-analysis
#9
Yu Luo, Wen-Long Li, Hai-Bin Qu
Due to the advantages of fast and noninvasive, requiring almost no sample preparation, supplying chemical and physical information, near infrared (NIR) spectroscopy is widely used in the pharmaceutical industry. In the life cycle of an established analytical method, rigorous validation should be performed before routine use. However,there is no detailed experimental standards or decision rules for the NIR methods validation currently, and various approaches were applied to validate the established NIR quantification models in literatures...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925141/-research-progress-on-standardization-study-of-nir-spectroscopy-based-method-for-quality-control-of-traditional-chinese-medicine
#10
Wen-Long Li, Hai-Bin Qu
In recent years, the near infrared (NIR) spectroscopy has gained wide acceptance within the quantitative analysis of traditional Chinese medicine (TCM). However, the lack of technical standards is the bottleneck problem in this process. To address this issue, standardization study of the NIR spectroscopy based method for the quantitative analysis of TCM is needed, in which the specific characteristics of TCM should be given full considerations. The main research contents include:the scope definition for the application of NIR spectroscopy in the TCM quantitative analysis field, the selection criteria for the sample pretreatment and spectral acquisition conditions, the rules for the model optimization and evaluation, and the regulations for the model update and transfer...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925140/-near-infrared-spectroscopy-based-process-trajectory-technology-and-its-application-in-monitoring-and-controlling-of-traditional-chinese-medicine-manufacturing-process
#11
Wen-Long Li, Hai-Bin Qu
In this paper, the principle of NIRS (near infrared spectroscopy)-based process trajectory technology was introduced.The main steps of the technique include:① in-line collection of the processes spectra of different technics; ② unfolding of the 3-D process spectra;③ determination of the process trajectories and their normal limits;④ monitoring of the new batches with the established MSPC (multivariate statistical process control) models.Applications of the technology in the chemical and biological medicines were reviewed briefly...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925139/-rapid-identification-and-evaluation-of-chinese-materia-medica-quality-by-near-infrared-spectroscopy
#12
Gang Bai, Guo-Yu Ding, Yuan-Yuan Hou, Min Jiang, Jie Gao
In recent years, the research object of traditional Chinese medicine(TCM) analysis has not just been limited to the common analysis technology, but focused on the key relationship between chemical ingredients and traditional functions, including Chinese material medica (CMM) attributes, chemical substance and biological function. Near infrared spectroscopy (NIR) analysis technology, due to its unique advantages, has been developed rapidly in the field of pharmaceutical analysis, especially in the TCM analysis...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28924568/convolutional-neural-network-for-high-accuracy-functional-near-infrared-spectroscopy-in-a-brain-computer-interface-three-class-classification-of-rest-right-and-left-hand-motor-execution
#13
Thanawin Trakoolwilaiwan, Bahareh Behboodi, Jaeseok Lee, Kyungsoo Kim, Ji-Woong Choi
The aim of this work is to develop an effective brain-computer interface (BCI) method based on functional near-infrared spectroscopy (fNIRS). In order to improve the performance of the BCI system in terms of accuracy, the ability to discriminate features from input signals and proper classification are desired. Previous studies have mainly extracted features from the signal manually, but proper features need to be selected carefully. To avoid performance degradation caused by manual feature selection, we applied convolutional neural networks (CNNs) as the automatic feature extractor and classifier for fNIRS-based BCI...
January 2018: Neurophotonics
https://www.readbyqxmd.com/read/28924567/rearrangeable-and-exchangeable-optical-module-with-system-on-chip-for-wearable-functional-near-infrared-spectroscopy-system
#14
Tsukasa Funane, Takashi Numata, Hiroki Sato, Shinsuke Hiraizumi, Yuichi Hasegawa, Hidenobu Kuwabara, Kiyoshi Hasegawa, Masashi Kiguchi
We developed a system-on-chip (SoC)-incorporated light-emitting diode (LED) and avalanche photodiode (APD) modules to improve the usability and flexibility of a fiberless wearable functional near-infrared spectroscopy (fNIRS) system. The SoC has a microprocessing unit and programmable circuits. The time division method and the lock-in method were used for separately detecting signals from different positions and signals of different wavelengths, respectively. Each module autonomously works for this time-divided-lock-in measurement with a high sensitivity for haired regions...
January 2018: Neurophotonics
https://www.readbyqxmd.com/read/28924566/comparison-of-oxyhemoglobin-and-deoxyhemoglobin-signal-reliability-with-and-without-global-mean-removal-for-digit-manipulation-motor-tasks
#15
Swethasri Dravida, Jack Adam Noah, Xian Zhang, Joy Hirsch
Functional near-infrared spectroscopy (fNIRS) could be well suited for clinical use, such as measuring neural activity before and after treatment; however, reliability and specificity of fNIRS signals must be ensured so that differences can be attributed to the intervention. This study compared the test-retest and longitudinal reliability of oxyhemoglobin and deoxyhemoglobin signals before and after spatial filtering. In the test-retest experiment, 14 participants were scanned on 2 days while performing four right-handed digit-manipulation tasks...
January 2018: Neurophotonics
https://www.readbyqxmd.com/read/28924565/nirs-based-cerebrovascular-regulation-assessment-exercise-and-cerebrovascular-reactivity
#16
Stephanie Miller, Kunal Mitra
Alterations to cerebral blood flow (CBF) have been implicated in diverse neurological conditions. Near-infrared spectroscopy (NIRS)-measured regional cerebral tissue oxygen saturation ([Formula: see text]) provides an estimate of oxygenation of interrogated cerebral volume useful in identifying variations in oxygen supply to cerebral tissue and in monitoring cerebrovascular function. [Formula: see text]-inhalation-based hypercapnic breathing challenges were used to simulate CBF dysregulation, utilizing NIRS to monitor the CBF autoregulatory response...
October 2017: Neurophotonics
https://www.readbyqxmd.com/read/28924564/signal-processing-of-functional-nirs-data-acquired-during-overt-speaking
#17
Xian Zhang, Jack Adam Noah, Swethasri Dravida, Joy Hirsch
Functional near-infrared spectroscopy (fNIRS) offers an advantage over traditional functional imaging methods [such as functional magnetic resonance imaging (fMRI)] by allowing participants to move and speak relatively freely. However, neuroimaging while actively speaking has proven to be particularly challenging due to the systemic artifacts that tend to be located in the critical brain areas. To overcome these limitations and enhance the utility of fNIRS, we describe methods for investigating cortical activity during spoken language tasks through refinement of deoxyhemoglobin (deoxyHb) signals with principal component analysis (PCA) spatial filtering to remove global components...
October 2017: Neurophotonics
https://www.readbyqxmd.com/read/28924563/functional-near-infrared-spectroscopy-in-movement-science-a-systematic-review-on-cortical-activity-in-postural-and-walking-tasks
#18
REVIEW
Fabian Herold, Patrick Wiegel, Felix Scholkmann, Angelina Thiers, Dennis Hamacher, Lutz Schega
Safe locomotion is a crucial aspect of human daily living that requires well-functioning motor control processes. The human neuromotor control of daily activities such as walking relies on the complex interaction of subcortical and cortical areas. Technical developments in neuroimaging systems allow the quantification of cortical activation during the execution of motor tasks. Functional near-infrared spectroscopy (fNIRS) seems to be a promising tool to monitor motor control processes in cortical areas in freely moving subjects...
October 2017: Neurophotonics
https://www.readbyqxmd.com/read/28921863/gender-differences-in-brain-networks-during-verbal-sternberg-tasks-a-simultaneous-near-infrared-spectroscopy-and-electro-encephalography-study
#19
Chenyang Gao, Jinyan Sun, Xiaoquan Yang, Hui Gong
Gender differences in psychological processes have been of great interest in a variety of fields including verbal fluency, emotion processing, and working memory. Previous studies suggested that women outperform men in verbal working memory (VWM). However, the inherent mechanisms are still unclear. To obtain a deeper insight into the gender differences in brain networks in VWM, this study used near-infrared spectroscopy (NIRS) and electro-encephalography (EEG) simultaneously to investigate gender-related brain networks during verbal Sternberg tasks...
September 17, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28921461/prediction-of-neoadjuvant-chemotherapy-response-using-diffuse-optical-spectroscopy-in-breast-cancer
#20
REVIEW
Ying-Hua Yu, Xiao Zhu, Qin-Guo Mo, Ying Cui
PURPOSE: Near-infrared diffuse optical spectroscopy (DOS) has been recently used to predict neoadjuvant chemotherapy response (NAC). In the present study, we explore the change in blood-oxygen content using DOS to predict NAC response against breast cancer. MATERIALS AND METHODS: A total of 20 patients were enrolled and underwent DOS scan with blood-oxygen detection before each treatment cycle. The first DOS scan was performed before NAC treatment (pretreatment), and subsequent scans were performed after each NAC treatment circle...
September 18, 2017: Clinical & Translational Oncology
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