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Ketamine neuroprotection

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https://www.readbyqxmd.com/read/27769874/preventive-effects-of-blueberry-extract-on-behavioral-and-biochemical-dysfunctions-in-rats-submitted-to-a-model-of-manic-behavior-induced-by-ketamine
#1
Gabriela Debom, Marta Gazal, Mayara Sandrielly Pereira Soares, Carlus Augustu Tavares do Couto, Bruna Mattos, Claiton Lencina, Manuella Pinto Kaster, Gabriele Codenonzi Ghisleni, Rejane Tavares, Elizandra Braganhol, Vitor Clasen Chaves, Flávio Henrique Reginatto, Francieli Stefanello, Roselia Maria Spanevello
The aim of the present study was to evaluate the protective effects of blueberry extract on oxidative stress and inflammatory parameters in a model of mania induced by ketamine administration in rats. Male rats were pretreated with blueberry extract (200mg/kg, once a day for 14days), lithium chloride (45mg/kg, mood stabilizer used as a positive control, twice a day for 14days), or vehicle. Between the 8th and 14th days, rats also received an injection of ketamine (25mg/kg) or vehicle. In the 15th day, thirty minutes after ketamine administration the hyperlocomotion of the animals was assessed in the open - field apparatus...
October 18, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27551511/xenon-mediated-neuroprotection-in-response-to-sustained-low-level-excitotoxic-stress
#2
J Lavaur, M Lemaire, J Pype, D Le Nogue, E C Hirsch, P P Michel
Noble gases such as xenon and argon have been reported to provide neuroprotection against acute brain ischemic/anoxic injuries. Herein, we wished to evaluate the protective potential of these two gases under conditions relevant to the pathogenesis of chronic neurodegenerative disorders. For that, we established cultures of neurons typically affected in Alzheimer's disease (AD) pathology, that is, cortical neurons and basal forebrain cholinergic neurons and exposed them to L-trans-pyrrolidine-2,4-dicarboxylic acid (PDC) to generate sustained, low-level excitotoxic stress...
2016: Cell Death Discovery
https://www.readbyqxmd.com/read/27529322/dexmedetomidine-induced-neuroapoptosis-is-dependent-on-its-cumulative-dose
#3
Jia-Ren Liu, Koichi Yuki, Chongwha Baek, Xiao-Hui Han, Sulpicio G Soriano
BACKGROUND: Dexmedetomidine (DEX) has inherent neuroprotective properties that have been attributed to the activation of prosurvival kinases. However, the impact of supraclinical doses of DEX on neuroapoptosis and neuronal viability has not been determined. METHODS: Rat pups and primary neuronal cells were treated with DEX or ketamine (KET) alone or in combination. Neuroapoptosis was measured by cleaved-caspase-3 expression and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining in brain sections...
October 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27329284/evaluation-of-acetylcholine-seizure-activity-and-neuropathology-following-high-dose-nerve-agent-exposure-and-delayed-neuroprotective-treatment-drugs-in-freely-moving-rats
#4
Cindy Acon-Chen, Jeffrey A Koenig, Garrett R Smith, Amber R Truitt, Thaddeus P Thomas, Tsung-Ming Shih
Organophosphorus nerve agents such as soman (GD) inhibit acetylcholinesterase, producing an excess of acetylcholine (ACh), which results in respiratory distress, convulsions and status epilepticus that leads to neuropathology. Several drugs (topiramate, clobazam, pregnanolone, allopregnanolone, UBP 302, cyclopentyladenosine [CPA], ketamine, midazolam and scopolamine) have been identified as potential neuroprotectants that may terminate seizures and reduce brain damage. To systematically evaluate their efficacy, this study employed in vivo striatal microdialysis and liquid chromatography to respectively collect and analyze extracellular ACh in freely moving rats treated with these drugs 20 min after seizure onset induced by a high dose of GD...
June 2016: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/27028535/ketamine-a-review-of-clinical-pharmacokinetics-and-pharmacodynamics-in-anesthesia-and-pain-therapy
#5
REVIEW
Marko A Peltoniemi, Nora M Hagelberg, Klaus T Olkkola, Teijo I Saari
Ketamine is a phencyclidine derivative, which functions primarily as an antagonist of the N-methyl-D-aspartate receptor. It has no affinity for gamma-aminobutyric acid receptors in the central nervous system. Ketamine shows a chiral structure consisting of two optical isomers. It undergoes oxidative metabolism, mainly to norketamine by cytochrome P450 (CYP) 3A and CYP2B6 enzymes. The use of S-ketamine is increasing worldwide, since the S(+)-enantiomer has been postulated to be a four times more potent anesthetic and analgesic than the R(-)-enantiomer and approximately two times more effective than the racemic mixture of ketamine...
September 2016: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/26981881/propofol-but-not-ketamine-or-midazolam-exerts-neuroprotection-after-ischaemic-injury-by-inhibition-of-toll-like-receptor-4-and-nuclear-factor-kappa-light-chain-enhancer-of-activated-b-cell-signalling-a-combined-in-vitro-and-animal-study
#6
Felix Ulbrich, Leonardo Eisert, Hartmut Buerkle, Ulrich Goebel, Nils Schallner
BACKGROUND: Propofol, midazolam and ketamine are widely used in today's anaesthesia practice. Both neuroprotective and neurotoxic effects have been attributed to all three agents. OBJECTIVE: To establish whether propofol, midazolam and ketamine in the same neuronal injury model exert neuroprotective effects on injured neurones in vitro and in vivo by modulation of the Toll-like receptor 4-nuclear factor kappa-light-chain-enhancer of activated B cells (TLR-4-NF-κB) pathway...
September 2016: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/26946305/regulatory-effects-of-anesthetics-on-nitric-oxide
#7
REVIEW
Wenguo Fan, Qin Liu, Xiao Zhu, Zhi Wu, Dongpei Li, Fang Huang, Hongwen He
Nitric oxide (NO) is a free radical gas in the biological system, which is produced by nitric oxide synthase (NOS) family. NO acts as a biological mediator and plays important roles in different systems in humans. The NO/NOS system exerts a broad spectrum of signaling functions involved in vasodilation, inflammation, oxidative stress, cardioprotection and neuroprotection. It has been demonstrated that intravenous and volatile anesthetics (such as propofol, ketamine, midazolam, isoflurane, sevoflurane, and desflurane, etc...
April 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/26932180/baicalin-attenuates-ketamine-induced-neurotoxicity-in-the-developing-rats-involvement-of-pi3k-akt-and-creb-bdnf-bcl-2-pathways
#8
Daiying Zuo, Li Lin, Yumiao Liu, Chengna Wang, Jingwen Xu, Feng Sun, Lin Li, Zengqiang Li, Yingliang Wu
Ketamine is widely used as an anesthetic in pediatric clinical practice. However, numerous studies have reported that exposure to ketamine during the developmental period induces neurotoxicity. Here we investigate the neuroprotective effects of baicalin, a natural flavonoid compound, against ketamine-induced apoptotic neurotoxicity in the cortex and hippocampus of the Sprague-Dawley postnatal day 7 (PND7) rat pups. Our results revealed that five continuous injections of ketamine (20 mg/kg) at 90-min intervals over 6 h induced obvious morphological damages of neuron by Nissl staining and apoptosis by TUNEL assays in the prefrontal cortex and hippocampus of PND7 rat pups...
August 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/26815259/clinical-and-histological-effects-of-the-intrathecal-administration-of-a-single-dose-of-dexmedetomidine-in-rabbits
#9
Hugh D de Pereira Cardoso, Natalie C Fim, Mariangela A Marques, Helio Mint, Vania M de Vasconcelos Machado, Daneshvari R Solanki, Rodrigo Moreira Lima, Ana L de Carvalho, Lais H Navarro, Eliana M Ganem
BACKGROUND: There is experimental evidence that dexmedetomidine has neuroprotective effects. So, it could be expected that its intrathecal or epidural administration presents no harm. However, whether dexmedetomidine is neurotoxic to the spinal cord remains to be fully elucidated. OBJECTIVE: To evaluate the effect of preservative-free dexmedetomidine administered as a subarachnoid single injection on the spinal cord and meninges of rabbits. STUDY DESIGN: Research article...
February 2016: Pain Physician
https://www.readbyqxmd.com/read/26709052/selective-regulation-of-neurosteroid-biosynthesis-under-ketamine-induced-apoptosis-of-cortical-neurons-in-vitro
#10
Jianli Li, Yang Yu, Bei Wang, Honghai Wu, Gai Xue, Yanning Hou
Numerous studies have suggested that ketamine administration can induce neuroapoptosis in primary cultured cortical neurons. Neurosteroids modulate neuronal function and serve important roles in the central nervous system, however the role of neurosteroids in neuroapoptosis induced by ketamine remains to be elucidated. The present study aimed to explore whether neurosteroidogenesis was a pivotal mechanism for neuroprotection against ketamine-induced neuroapoptosis, and whether it may be selectively regulated under ketamine-induced neuroapoptosis conditions in primary cultured cortical neurons...
February 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26703367/ilex-paraguariensis-hydroalcoholic-extract-exerts-antidepressant-like-and-neuroprotective-effects-involvement-of-the-nmda-receptor-and-the-l-arginine-no-pathway
#11
Fabiana K Ludka, Lori de Fátima Tandler, Gislaine Kuminek, Gislaine Olescowicz, Jonatha Jacobsen, Simone Molz
Ilex paraguariensis St. Hilaire (Aquifoliaceae) is a typical plant from South America. Preclinical studies have reported the effect of I. paraguariensis-based preparations on different alterations in the brain. This study aimed to examine the antidepressant-like and neuroprotective effects of I. paraguariensis hydroalcoholic extract (IpHE). The role of the N-methyl-D-aspartate receptor and the L-arginine-nitric oxide pathway in the IpHE antidepressant-like effect was also evaluated. Using the tail suspension test, we showed that IpHE (0...
June 2016: Behavioural Pharmacology
https://www.readbyqxmd.com/read/26613895/duality-of-antidepressants-and-neuroprotectants
#12
Yousef Tizabi
The co-morbidity of neuropsychiatric disorders, particularly major depressive disorder (MDD) with neurodegenerative diseases, in particular Parkinson's disease (PD) is now well recognized. Indeed, it is suggested that depressive disorders, especially in late life, may be an indication of latent neurodegeneration. Thus, it is not unreasonable to expect that deterrents of MDD may also deter the onset and/or progression of the neurodegenerative diseases including PD. In this review, examples of neuroprotective efficacy of established as well as prospective antidepressants are provided...
July 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/26587403/influence-of-ketamine-on-early-postoperative-cognitive-function-after-orthopedic-surgery-in-elderly-patients
#13
Ki Hwa Lee, Ji Yeon Kim, Jeong Won Kim, Jang Su Park, Kyu Won Lee, Sang Yoon Jeon
BACKGROUND: Postoperative cognitive dysfunction (POCD) is a serious and frequent complication after surgery, especially in elderly patients. Ketamine is an N-methyl D-aspartic acid receptor antagonist with demonstrated neuroprotective effects. An intravenous bolus of a sub-anesthetic dose (0.5 mg/kg) of ketamine can reduce postoperative delirium (POD) and POCD after cardiac surgery. But, the influence of ketamine on early POCD after non-cardiac surgery is unclear. OBJECTIVES: The current study aimed to evaluate the influence of ketamine on early postoperative cognitive function after orthopedic surgery in elderly patients...
October 2015: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/26579580/anti-inflammatory-effects-of-nesfatin-1-in-rats-with-acetic-acid-induced-colitis-and-underlying-mechanisms
#14
C C Ozturk, S Oktay, M Yuksel, D Akakin, A Yarat, O Kasimay Cakir
Mucosal balance impairment, bacterial over-proliferation, cytokines, inflammatory mediators are known as responsible for inflammatory bowel disease. Besides known anorexigenic, neuroprotective, and anti-apoptotic effects, the major effect of nesfatin-1 on colitis is unknown. Our aim was to investigate the possible anti-inflammatory effects of nesfatin-1 in acetic acid induced colitis model and potential underlying mechanisms. Male Spraque-Dawley rats were anesthetized by intraperitoneal ketamine (100 mg/kg) and chlorpromazine (0...
October 2015: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/26215537/gender-and-estrous-cycle-influences-on-behavioral-and-neurochemical-alterations-in-adult-rats-neonatally-administered-ketamine
#15
Vládia Célia Moreira Borella, Mary V Seeman, Rafaela Carneiro Cordeiro, Júnia Vieira dos Santos, Marcos Romário Matos de Souza, Ethel Nunes de Sousa Fernandes, Aline Santos Monte, Silvânia Maria Mendes Vasconcelos, John P Quinn, David F de Lucena, André F Carvalho, Danielle Macêdo
Neonatal N-methyl-D-aspartate (NMDA) receptor blockade in rodents triggers schizophrenia (SCZ)-like alterations during adult life. SCZ is influenced by gender in age of onset, premorbid functioning, and course. Estrogen, the hormone potentially driving the gender differences in SCZ, is known to present neuroprotective effects such as regulate oxidative pathways and the expression of brain-derived neurotrophic factor (BDNF). Thus, the aim of this study was to verify if differences in gender and/or estrous cycle phase during adulthood would influence the development of behavioral and neurochemical alterations in animals neonatally administered ketamine...
May 2016: Developmental Neurobiology
https://www.readbyqxmd.com/read/26205086/beneficial-effects-of-a-ketamine-atropine-combination-in-soman-poisoned-rats-under-a-neutral-thermal-environment
#16
Laure Barbier, Frédéric Canini, Céline Giroud, Claire Beaup, Annie Foquin, Renaud Maury, Josiane Denis, André Peinnequin, Frédéric Dorandeu
Exposure to organophosphorus (OP) compounds, such as pesticides and the chemical warfare agents (soman and sarin), respectively represents a major health problem and a threat for civilian and military communities. OP poisoning may induce seizures, status epilepticus and even brain lesions if untreated. We recently proved that a combination of atropine sulfate and ketamine, a glutamatergic antagonist, was effective as an anticonvulsant and neuroprotectant in mice and guinea-pigs exposed to soman. Since OP exposure may also occur in conditions of heat strain due to climate, wearing of protective gears or physical exercise, we previously demonstrated that ketamine/atropine association may be used in a hot environment without detrimental effects...
September 2015: Neurotoxicology
https://www.readbyqxmd.com/read/25998886/preventive-effect-of-cecropia-pachystachya-against-ketamine-induced-manic-behavior-and-oxidative-stress-in-rats
#17
Marta Gazal, Fernanda N Kaufmann, Bruna A Acosta, Pathise Souto Oliveira, Matheus R Valente, Caroline Flach Ortmann, Régis Sturbelle, Claiton L Lencina, Francieli M Stefanello, Manuella P Kaster, Flávio Henrique Reginatto, Gabriele Ghisleni
Cecropia species are widely used in traditional medicine by its anti-diabetic, anti-hypertensive and anti-inflammatory properties. In the present study, we investigated the neuroprotective and antioxidant effects of the crude aqueous extract from Cecropia pachystachya leaves in a rat model of mania induced by ketamine. The results indicated that ketamine treatment (25 mg/kg i.p., for 8 days) induced hyperlocomotion in the open-field test and oxidative damage in prefrontal cortex and hippocampus, evaluated by increased lipid peroxidation, carbonyl protein formation and decreased total thiol content...
July 2015: Neurochemical Research
https://www.readbyqxmd.com/read/25966123/neuroprotective-effect-of-ketamine-on-acute-spinal-cord-injury-in-rats
#18
S H Tang, J G Yu, J J Li, J Y Sun
The aim of this study was to investigate the neuroprotective effects of ketamine during acute spinal cord injury in rats. Sprague Dawley (SD) rats (N = 70) were randomly divided into three groups: sham-operated (N = 10), control (N = 30), and treatment (N = 30) groups. The moderate spinal cord injury model was established. After injury, the sham-operated group received no drug, the treatment group received intraperitoneal ketamine injections, and the control group received intraperitoneal normal saline injections...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/25943498/-ketamine-as-anesthetic-agent-in-electroconvulsion-therapy
#19
COMPARATIVE STUDY
C Janke, J M Bumb, S S Aksay, M Thiel, L Kranaster, A Sartorius
BACKGROUND: Electroconvulsive therapy (ECT) is a well-established, safe and effective treatment for severe psychiatric disorders. Ketamine is known as a core medication in anesthesiology and has recently gained interest in ECT practice as there are three potential advantages: (1) ketamine has no anticonvulsive actions, (2) according to recent studies ketamine could possess a unique intrinsic antidepressive potential and (3) ketamine may exhibit neuroprotective properties, which again might reduce the risk of cognitive side effects associated with ECT...
May 2015: Der Anaesthesist
https://www.readbyqxmd.com/read/25886322/ketamine-current-applications-in-anesthesia-pain-and-critical-care
#20
REVIEW
Madhuri S Kurdi, Kaushic A Theerth, Radhika S Deva
Ketamine was introduced commercially in 1970 with the manufacturer's description as a "rapidly acting, nonbarbiturate general anesthetic" and a suggestion that it would be useful for short procedures. With the help of its old unique pharmacological properties and newly found beneficial clinical properties, ketamine has survived the strong winds of time, and it currently has a wide variety of clinical applications. It's newly found neuroprotective, antiinflammatory and antitumor effects, and the finding of the usefulness of low dose ketamine regimens have helped to widen the clinical application profile of ketamine...
September 2014: Anesthesia, Essays and Researches
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