Elizabeth R Barrow, Evelina Valionyte, Chris R Baxter, Yi Yang, Sharon Herath, William A O'Connell, Justyna Lopatecka, Alexander Strachan, Waldemar Woznica, Holly N Stephenson, Gyorgy Fejer, Vikram Sharma, Boxun Lu, Shouqing Luo
Autophagy and ribonucleoprotein granules, such as P-bodies (PBs) and stress granules, represent vital stress responses to maintain cellular homeostasis. SQSTM1/p62 phase-separated droplets are known to play critical roles in selective autophagy; however, it is unknown whether p62 can exist as another form in addition to its autophagic droplets. Here, we found that, under stress conditions, including proteotoxicity, endotoxicity, and oxidation, autophagic p62 droplets are transformed to a type of enlarged PBs, termed p62-dependent P-bodies (pd-PBs)...
March 7, 2024: Cell Reports