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https://www.readbyqxmd.com/read/28337283/intracoronary-hypothermia-for-acute-myocardial-infarction-in-the-isolated-beating-pig-heart
#1
Luuk C Otterspoor, Lokien X van Nunen, Tilaï T Rosalina, Marcel Van't Veer, Sjoerd Van Tuijl, Marco Stijnen, Marcel Cm Rutten, Frans N van de Vosse, Nico Hj Pijls
Hypothermia may attenuate reperfusion injury and thereby improve acute myocardial infarction therapy. Systemic cooling trials failed to reduce infarct size, perhaps because the target temperature was not reached fast enough. The use of selective intracoronary hypothermia combined with intracoronary temperature monitoring allows for titrating to target temperature and optimizing the cooling rate. We aimed to the test the feasibility of intracoronary cooling for controlled, selective myocardial hypothermia in an isolated beating pig heart...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28330964/thermoregulatory-inversion-a-novel-thermoregulatory-paradigm
#2
Domenico Tupone, Georgina Cano, Shaun F Morrison
To maintain core body temperature in mammals, the normal CNS thermoregulatory reflex networks produce an increase in brown adipose tissue (BAT) thermogenesis in response to skin cooling, and an inhibition of the sympathetic outflow to BAT during skin rewarming. In contrast, these normal thermoregulatory reflexes appear to be inverted in hibernation/torpor: thermogenesis is inhibited during exposure to a cold environment, allowing dramatic reductions in core temperature and metabolism, and thermogenesis is activated during skin rewarming, contributing to a return of normal body temperature...
March 22, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28325048/photoinduced-single-and-multiple-electron-dynamics-processes-enhanced-by-quantum-confinement-in-lead-halide-perovskite-quantum-dots
#3
Dayton Jon Vogel, Andrei Kryjevski, Talgat M Inerbaev, Dmitri S Kilin
Methyl-ammonium lead iodide perovskite (MAPbI3) is a promising material for photovoltaic devices. A modification of the MAPbI3 into confined nanostructures is expected to further increase efficiency of solar energy conversion. Photo-excited dynamic processes in a MAPbI3 quantum dot (QD) have been modeled by many-body perturbation theory and nonadiabatic dynamics. A photoexcitation is followed by either exciton cooling (EC), its radiative (RR) or non-radiative recombination (NRR), or multi-exciton generation (MEG) processes...
March 21, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28314947/seasonal-adaptations-in-energy-budgeting-in-the-primate-lepilemur-leucopus
#4
Janina Bethge, Bianca Wist, Eleanor Stalenberg, Kathrin Dausmann
The spiny forest of South Madagascar is one of the driest and most unpredictable habitats in Africa. The small-bodied, nocturnal primate Lepilemur leucopus lives in this harsh habitat with high diurnal and seasonal changes in ambient temperature. In this study, we investigated seasonal adaptions in energy budgeting of L. leucopus, which allow it to live under these conditions by measuring resting metabolic rate using open-flow respirometry. No signs of heterothermy were detected, and resting metabolic rate was significantly lower in the warmer wet season than in the colder dry season...
March 17, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28303342/comparison-of-fabric-skins-for-the-simulation-of-sweating-on-thermal-manikins
#5
Barbara Koelblen, Agnes Psikuta, Anna Bogdan, Simon Annaheim, René M Rossi
Sweating is an important thermoregulatory process helping to dissipate heat and, thus, to prevent overheating of the human body. Simulations of human thermo-physiological responses in hot conditions or during exercising are helpful for assessing heat stress; however, realistic sweating simulation and evaporative cooling is needed. To this end, thermal manikins dressed with a tight fabric skin can be used, and the properties of this skin should help human-like sweat evaporation simulation. Four fabrics, i.e...
March 16, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28302571/alpha-9-nicotinic-acetylcholine-receptors-mediate-hypothermic-responses-elicited-by-provocative-motion-in-mice
#6
Longlong Tu, Lauren Poppi, John Rudd, Ethan T Cresswell, Doug W Smith, Alan Brichta, Eugene Nalivaiko
Hypothermic responses accompany motion sickness in humans and can be elicited by provocative motion in rats. We aimed to determine the potential role in these responses of the efferent cholinergic vestibular innervation. To this end, we used knockout (KO) mice lacking α9 cholinoreceptor subunit predominantly expressed in the vestibular hair cells and CBA strain as a wild-type (WT) control. In WT mice, circular horizontal motion (1Hz, 4cm radius, 20min) caused rapid and dramatic falls in core body temperature and surface head temperature associated with a transient rise in the tail temperature; these responses were substantially attenuated in KO mice; changes were (WT vs...
March 14, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28298110/near-infrared-overtone-voh-2-%C3%A2-0-spectroscopy-of-ne-h2o-clusters
#7
Michael P Ziemkiewicz, Christian Pluetzer, Michael Wojcik, Jérôme Loreau, Ad van der Avoird, David J Nesbitt
Vibrationally state selective overtone spectroscopy and dynamics of weakly bound Ne-H2O complexes (D0((para)) = 31.67 cm(-1), D0((ortho)) = 34.66 cm(-1)) are reported for the first time, based on near infrared excitation of van der Waals cluster bands correlating with vOH = 2 ← 0 overtone transitions (|02(-)⟩←|00(+)⟩ and |02(+)⟩←|00(+)⟩) out of the ortho (101) and para (000) internal rotor states of the H2O moiety. Quantum theoretical calculations for nuclear motion on a high level ab initio potential energy surface (CCSD(T)/VnZ-f12 (n = 3,4), corrected for basis set superposition error and extrapolated to the complete basis set limit) are employed for assignment of Σ←Σ,Π←Σ, and Σ←Π infrared bands in the overtone spectra, where Σ(K = 0) and Π (K = 1) represent approximate projections (K) of the body angular momentum along the Ne-H2O internuclear axis...
March 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28295755/evidence-for-a-functional-vasoconstrictor-role-for-atp-in-the-human-cutaneous-microvasculature
#8
James A Lang, Alex C Krajek, Kevin A Smaller
Noradrenaline is responsible for eliciting ∼60% of the reflex cutaneous vasoconstriction (VC) response in young adults, whereas the remainder is due to one or more unidentified coreleased sympathetic adrenergic neurotransmitter(s). Inconsistent evidence has placed neuropeptide Y in this role; however, other putative cotransmitters have yet to be tested. We hypothesize that ATP contributes to the reflex cutaneous VC response. Two protocols were conducted in young adults (n = 10); both involved the placement of three microdialysis (MD) probes in forearm skin and whole-body cooling (Tsk  = 30...
March 10, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28283794/the-role-of-basking-in-the-development-of-endothermy-and-torpor-in-a-marsupial
#9
Chris B Wacker, Bronwyn M McAllan, Gerhard Körtner, Fritz Geiser
Marsupials have a slow rate of development and this allows a detailed examination of thermoregulatory developmental changes and stages. We quantified the cooling rates of marsupial dunnarts (Sminthopsis crassicaudata) at 40-56 days (d) old, and torpor and basking behaviour in animals given the option to bask in four age groups from 60 to 150 d. The development of thermoregulation was a continuum, but was characterised by three major thermoregulatory stages: (1) at 40 d, animals were unable to maintain a constant high body temperature during short-term cold exposure; (2) at 60 d, animals could maintain a high T b for the first part of the night at an ambient temperature of 15...
March 10, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28273599/radiocesium-in-migratory-aquatic-game-birds-using-contaminated-u-s-department-of-energy-reactor-cooling-reservoirs-a-long-term-perspective
#10
Robert A Kennamer, Ricki E Oldenkamp, James C Leaphart, Joshua D King, A Lawrence Bryan, James C Beasley
Low-level releases of radiocesium into former nuclear reactor cooling-reservoirs on the U.S. Department of Energy's Savannah River Site (SRS) in South Carolina, USA, dating primarily to the late 1950s and early 1960s, have allowed examination of long-term contaminant attenuation in biota occupying these habitats. Periodic collections of migratory game birds since the 1970s have documented (137)Cs (radiocesium) activity concentrations in birds of SRS reservoirs, including mainly Par Pond and Pond B. In this study, during 2014 and 2015 we released wild-caught American coots (Fulica americana) and ring-necked ducks (Aythya collaris) onto Pond B...
March 5, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28269208/poly-n-isopropylacrylamide-hydrogel-based-shape-adjustable-polyimide-films-triggered-by-near-human-body-temperature
#11
Huanqing Cui, Xuemin Du, Juan Wang, Tianhong Tang, Tianzhun Wu
Hydrogel-based shape-adjustable films were successfully fabricated via grafting poly(N-isopropylacrylamide) (PNIPAM) onto one side of polyimide (PI) films. The prepared PI-g-PNIPAM films exhibited rapid, reversible, and repeatable bending/unbending property by heating to near-human-body temperature (37 °C) or cooling to 25 °C. The excellent property of PI-g-PNIPAM films resulted from a lower critical solution temperature (LCST) of PNIPAM at about 32 °C. Varying the thickness of PNIPAM hydrogel layer regulated the thermo-responsive shape bending degree and response speed of PI-g-PNIPAM films...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28258897/local-hypothermia-as-a-radioprotector-of-the-rectal-wall-during-prostate-stereotactic-body-radiation-therapy
#12
Brian A Hrycushko, Rajiv Chopra, James W Sayre, James A Richardson, Michael R Folkert, Robert D Timmerman, Paul M Medin
PURPOSE: To compare the single-fraction dose-related incidence of rectal obstruction and/or bleeding in normothermic and hypothermic rectums of a rat model. METHODS AND MATERIALS: A 1.9-cm length of rectum was irradiated with a single fraction in 57 Sprague-Dawley rats using a dedicated image-guided small animal irradiator and Monte Carlo-based treatment planning system. All rats had a rectal temperature control apparatus placed during irradiation and were stratified to achieve either a normothermic (37°C) or hypothermic (15°C) rectal wall temperature...
January 11, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28254751/glycinergic-inhibition-of-bat-sympathetic-premotor-neurons-in-rostral-raphe-pallidus
#13
Ellen Paula Santos da Conceição, Christopher J Madden, Shaun F Morrison
The rostral raphe pallidus (rRPa) contains sympathetic premotor neurons controlling thermogenesis in brown adipose tissue (BAT). We sought to determine if a tonic activation of glycineA receptors (GlyAR) in the rRPa contributes to the inhibitory regulation of BAT SNA and of cardiovascular parameters in anesthetized rats. Nanoinjection of the GlyAR antagonist, strychnine (STR), into the rRPa of intact rats increased BAT sympathetic nerve activity (SNA, peak: +495%), BAT temperature (TBAT, +1.1 ºC), expired CO2, (+0...
March 2, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28252819/effect-of-the-cooling-suit-method-applied-to-individuals-with-multiple-sclerosis-on-fatigue-and-activities-of-daily-living
#14
Fatma Özkan Tuncay, Mukadder Mollaoğlu
AIM AND OBJECTIVES: This study was conducted to determine the effects of cooling suit on fatigue and activities of daily living of individuals with multiple sclerosis (MS). BACKGROUND: Fatigue is one of the most common symptoms in people with MS and adversely affects their activities of daily living. Studies evaluating fatigue associated with MS have reported that most of the fatigue cases are related to the increase in body temperature and that cooling therapy is effective in coping with fatigue...
March 2, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28237918/optimal-control-of-inspired-perfluorocarbon-temperature-for-ultrafast-hypothermia-induction-by-total-liquid-ventilation-in-adult-patient-model
#15
Mathieu Nadeau, Michael Sage, Matthias Kohlhauer, Julien Mousseau, Jonathan Vandamme, Etienne Fortin-Pellerin, Jean-Paul Praud, Renaud Tissier, Herve Walti, Philippe Micheau
OBJECTIVE: Recent preclinical studies have shown that therapeutic hypothermia induced in less than 30 min by total liquid ventilation (TLV) strongly improves the survival rate after cardiac arrest. When the lung is ventilated with a breathable perfluorocarbon liquid, the inspired perfluorocarbon allows to control efficiently the cooling process of the organs. While TLV can rapidly cool animals, the cooling speed in humans remains unknown. The objective is to predict the efficiency and safety of ultrafast cooling by TLV in adult humans...
February 20, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28227438/poly-n-isopropylacrylamide-hydrogel-based-shape-adjustable-polyimide-films-triggered-by-near-human-body-temperature
#16
Huanqing Cui, Xuemin Du, Juan Wang, Tianhong Tang, Tianzhun Wu, Huanqing Cui, Xuemin Du, Juan Wang, Tianhong Tang, Tianzhun Wu, Huanqing Cui, Tianzhun Wu, Xuemin Du, Tianhong Tang, Juan Wang
Hydrogel-based shape-adjustable films were successfully fabricated via grafting poly(N-isopropylacrylamide) (PNIPAM) onto one side of polyimide (PI) films. The prepared PI-g-PNIPAM films exhibited rapid, reversible, and repeatable bending/unbending property by heating to near-human-body temperature (37 °C) or cooling to 25 °C. The excellent property of PI-g-PNIPAM films resulted from a lower critical solution temperature (LCST) of PNIPAM at about 32 °C. Varying the thickness of PNIPAM hydrogel layer regulated the thermo-responsive shape bending degree and response speed of PI-g-PNIPAM films...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225022/core-shell-nanoparticle-arrays-double-the-strength-of-steel
#17
J-B Seol, S-H Na, B Gault, J-E Kim, J-C Han, C-G Park, D Raabe
Manipulating structure, defects and composition of a material at the atomic scale for enhancing its physical or mechanical properties is referred to as nanostructuring. Here, by combining advanced microscopy techniques, we unveil how formation of highly regular nano-arrays of nanoparticles doubles the strength of an Fe-based alloy, doped with Ti, Mo, and V, from 500 MPa to 1 GPa, upon prolonged heat treatment. The nanoparticles form at moving heterophase interfaces during cooling from the high-temperature face-centered cubic austenite to the body-centered cubic ferrite phase...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28215136/protocol-and-statistical-analysis-plan-for-the-randomised-evaluation-of-active-control-of-temperature-versus-ordinary-temperature-management-reactor-trial
#18
Paul J Young, Michael J Bailey, Richard W Beasley, Ross C Freebairn, Naomi E Hammond, Frank M P van Haren, Meg L Harward, Seton J Henderson, Diane M Mackle, Colin J McArthur, Shay P McGuinness, John A Myburgh, Manoj K Saxena, Anne Turner, Steve A R Webb, Rinaldo Bellomo
BACKGROUND: Body temperature can be reduced in febrile patients in the intensive care unit using medicines and physical cooling devices, but it is not known whether systematically preventing and treating fever reduces body temperature compared with standard care. OBJECTIVE: To describe the study protocol and statistical analysis plan for the Randomised Evaluation of Active Control of Temperature versus Ordinary Temperature Management (REACTOR) trial. DESIGN, SETTING AND PARTICIPANTS: Protocol for a phase II, multicentre trial to be conducted in Australian and New Zealand ICUs admitting adult patients...
March 2017: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/28211726/realization-of-translational-symmetry-in-trapped-cold-ion-rings
#19
Hao-Kun Li, Erik Urban, Crystal Noel, Alexander Chuang, Yang Xia, Anthony Ransford, Boerge Hemmerling, Yuan Wang, Tongcang Li, Hartmut Häffner, Xiang Zhang
We crystallize up to 15 ^{40}Ca^{+} ions in a ring with a microfabricated silicon surface Paul trap. Delocalization of the Doppler laser-cooled ions shows that the translational symmetry of the ion ring is preserved at millikelvin temperatures. By characterizing the collective motion of the ion crystals, we identify homogeneous electric fields as the dominant symmetry-breaking mechanism at this energy scale. With increasing ion numbers, such detrimental effects are reduced. We predict that, with only a ten-ion ring, uncompensated homogeneous fields will not break the translational symmetry of the rotational ground state...
February 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28207294/validity-of-core-temperature-measurements-at-3-rectal-depths-during-rest-exercise-cold-water-immersion-and-recovery
#20
Kevin C Miller, Lexie E Hughes, Blaine C Long, William M Adams, Douglas J Casa
CONTEXT:  No evidence-based recommendation exists regarding how far clinicians should insert a rectal thermistor to obtain the most valid estimate of core temperature. Knowing the validity of temperatures at different rectal depths has implications for exertional heat-stroke (EHS) management. OBJECTIVE:  To determine whether rectal temperature (Trec) taken at 4 cm, 10 cm, or 15 cm from the anal sphincter provides the most valid estimate of core temperature (as determined by esophageal temperature [Teso]) during similar stressors an athlete with EHS may experience...
February 16, 2017: Journal of Athletic Training
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