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https://www.readbyqxmd.com/read/15961456/identification-of-nine-human-specific-frameshift-mutations-by-comparative-analysis-of-the-human-and-the-chimpanzee-genome-sequences
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COMPARATIVE STUDY
Yoonsoo Hahn, Byungkook Lee
MOTIVATION: The recent release of the draft sequence of the chimpanzee genome is an invaluable resource for finding genome-wide genetic differences that might explain phenotypic differences between humans and chimpanzees. AVAILABILITY: In this paper, we describe a simple procedure to identify potential human-specific frameshift mutations that occurred after the divergence of human and chimpanzee. The procedure involves collecting human coding exons bearing insertions or deletions compared with the chimpanzee genome and identification of homologs from other species, in support of the mutations being human-specific...
June 2005: Bioinformatics
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