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https://www.readbyqxmd.com/read/28241641/portable-high-accuracy-non-absorbing-laser-power-measurement-at-kilowatt-levels-by-means-of-radiation-pressure
#1
Paul Williams, Joshua Hadler, Frank Maring, Robert Lee, Kyle Rogers, Brian Simonds, Matthew Spidell, Michelle Stephens, Ari Feldman, John Lehman
We describe a non-traditional optical power meter which measures radiation pressure to accurately determine a laser's optical power output. This approach traces its calibration of the optical watt to the kilogram. Our power meter is designed for high-accuracy and portability with the capability of multi-kilowatt measurements whose upper power limit is constrained only by the mirror quality. We provide detailed uncertainty evaluation and validate experimentally an average expanded relative uncertainty of 0.016 from 1 kW to 10 kW...
February 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28241526/stitching-interferometry-of-full-cylinder-by-use-of-the-first-order-approximation-of-cylindrical-coordinate-transformation
#2
Junzheng Peng, Yingjie Yu, Dingfu Chen, Hongwei Guo, Jinggang Zhong, Mingyi Chen
Since the cylinder surface is closed and periodic in the azimuthal direction, traditional stitching interferometry cannot be used to yield the 360° form map. This paper describes a full cylinder stitching interferometry based on the first-order approximation of cylindrical coordinate transformation. First, it introduces cylindrical projection, which allows us to determine the overlap region of the cylinder without ambiguity. Second, the relationship between the variations of radial coordinates and the movement errors of the rotational stage is derived from the first-order approximation of cylindrical coordinate transformation...
February 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28241434/data-collection-and-analysis-using-wearable-sensors-for-monitoring-knee-range-of-motion-after-total-knee-arthroplasty
#3
Chih-Yen Chiang, Kun-Hui Chen, Kai-Chun Liu, Steen Jun-Ping Hsu, Chia-Tai Chan
Total knee arthroplasty (TKA) is the most common treatment for degenerative osteoarthritis of that articulation. However, either in rehabilitation clinics or in hospital wards, the knee range of motion (ROM) can currently only be assessed using a goniometer. In order to provide continuous and objective measurements of knee ROM, we propose the use of wearable inertial sensors to record the knee ROM during the recovery progress. Digitalized and objective data can assist the surgeons to control the recovery status and flexibly adjust rehabilitation programs during the early acute inpatient stage...
February 22, 2017: Sensors
https://www.readbyqxmd.com/read/28241362/adjusted-analyses-in-studies-addressing-therapy-and-harm-users-guides-to-the-medical-literature
#4
Thomas Agoritsas, Arnaud Merglen, Nilay D Shah, Martin O'Donnell, Gordon H Guyatt
Observational studies almost always have bias because prognostic factors are unequally distributed between patients exposed or not exposed to an intervention. The standard approach to dealing with this problem is adjusted or stratified analysis. Its principle is to use measurement of risk factors to create prognostically homogeneous groups and to combine effect estimates across groups.The purpose of this Users' Guide is to introduce readers to fundamental concepts underlying adjustment as a way of dealing with prognostic imbalance and to the basic principles and relative trustworthiness of various adjustment strategies...
February 21, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28241247/peritoneal-dialysis-vs-furosemide-for-prevention-of-fluid-overload-in-infants-after-cardiac-surgery-a-randomized-clinical-trial
#5
David M Kwiatkowski, Stuart L Goldstein, David S Cooper, David P Nelson, David L S Morales, Catherine D Krawczeski
Importance: Fluid overload after congenital heart surgery is frequent and a major cause of morbidity and mortality among infants. Many programs have adopted the use of peritoneal dialysis (PD) for fluid management; however, its benefits compared with those of traditional diuretic administration are unknown. Objective: To determine whether infants randomized to PD vs furosemide for the treatment of oliguria have a higher incidence of negative fluid balance on postoperative day 1, as well as avoidance of 10% fluid overload; shorter duration of mechanical ventilation, intensive care unit stay, and inotrope use; and fewer electrolyte abnormalities...
February 20, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28241077/%C3%AE-amanitin-resistance-in-drosophila-melanogaster-a-genome-wide-association-approach
#6
Chelsea L Mitchell, Catrina E Latuszek, Kara R Vogel, Ian M Greenlund, Rebecca E Hobmeier, Olivia K Ingram, Shannon R Dufek, Jared L Pecore, Felicia R Nip, Zachary J Johnson, Xiaohui Ji, Hairong Wei, Oliver Gailing, Thomas Werner
We investigated the mechanisms of mushroom toxin resistance in the Drosophila Genetic Reference Panel (DGRP) fly lines, using genome-wide association studies (GWAS). While Drosophila melanogaster avoids mushrooms in nature, some lines are surprisingly resistant to α-amanitin-a toxin found solely in mushrooms. This resistance may represent a pre-adaptation, which might enable this species to invade the mushroom niche in the future. Although our previous microarray study had strongly suggested that pesticide-metabolizing detoxification genes confer α-amanitin resistance in a Taiwanese D...
2017: PloS One
https://www.readbyqxmd.com/read/28240907/full-characterization-of-the-mechanical-properties-of-11-50nm-ultrathin-films-influence-of-network-connectivity-on-the-poisson-s-ratio
#7
Jorge N Hernandez-Charpak, Kathleen M Hoogeboom-Pot, Qing Li, Travis D Frazer, Joshua L Knobloch, Marie Tripp, Sean W King, Erik H Anderson, Weilun Chao, Margaret M Murnane, Henry C Kapteyn, Damiano Nardi
Precise characterization of the mechanical properties of ultrathin films is of paramount importance for both a fundamental understanding of nanoscale materials and for continued scaling and improvement of nanotechnology. In this work, we use coherent extreme ultraviolet beams to characterize the full elastic tensor of isotropic ultrathin films down to 11nm in thickness. We simultaneously extract the Young's modulus and Poisson's ratio of low-k a-SiC:H films with varying degrees of hardness and average network connectivity in a single measurement...
February 27, 2017: Nano Letters
https://www.readbyqxmd.com/read/28240643/heart-allograft-preservation-an-arduous-journey-from-the-donor-to-the-recipient
#8
Michiel Erasmus, Arne Neyrink, Mario Sabatino, Luciano Potena
PURPOSE OF REVIEW: The discrepancy between needs and availability of organs for heart transplantation may be partially reduced by improving the utilization of organs currently deemed unsuitable. Strategies to achieve this goal need optimization of the entire process of organ procurement, transportation, and functional recovery after transplant. RECENT FINDINGS: In the latest years, several studies reported improvements in organ utilization after appropriate donor management, and management of heart transportation is approaching a new era...
February 24, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28240462/laparoscopic-management-of-hydatid-cyst-of-the-liver
#9
Y Yağmur, S Akbulut, S Gümüş, M Babür, M A Can
BACKGROUND: Hydatid liver disease management has evolved from traditional operative approaches to the increasing application of laparoscopic treatments. We aimed to prospectively assess the early outcomes of laparoscopic treatment at our institution. PATIENTS AND METHODS: Forty-four patients with hydatid disease of liver were screened with ultrasonography and computed tomography of the abdomen to exclude Gharbi type V cysts. The distribution of cyst sizes was: 1-4 cm, 10; 5-10 cm, 24; 10-15 cm, 8; > 15 cm, 2 patients...
September 2016: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28240182/integration-of-novel-materials-and-advanced-omics-technologies-into-new-vaccine-design
#10
Wenzhen Liao, Tian-Tian Zhang, Liqian Gao, Su Seong Lee, Jie Xu, Han Zhang, Zhaogang Yang, Zhaoyu Liu, Wen Li
Designing new vaccines is one of the most challenging tasks for public health to prevent both infectious and chronic diseases. Even though many research scientists have spent great efforts in improving the specificity, sensitivity and safety of current available vaccines, there are still much space on how to effectively combine different biomaterials and technologies to design universal or personalized vaccines. Traditionally, vaccines were made based on empirical approaches designed to mimic immunity induced by natural infection...
February 24, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28239782/inhibition-of-klebsiella-pneumoniae-growth-by-selected-australian-plants-natural-approaches-for-the-prevention-and-management-of-ankylosing-spondylitis
#11
V Winnett, J Sirdaarta, A White, F M Clarke, I E Cock
A wide variety of herbal remedies are used in traditional Australian medicine to treat inflammatory disorders, including autoimmune inflammatory diseases. One hundred and six extracts from 40 native Australian plant species traditionally used for the treatment of inflammation and/or to inhibit bacterial growth were investigated for their ability to inhibit the growth of a microbial trigger for ankylosing spondylitis (K. pneumoniae). Eighty-six of the extracts (81.1%) inhibited the growth of K. pneumoniae. The D...
February 27, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28238959/superiority-of-robotic-surgery-for-cervical-cancer-in-comparison-with-traditional-approaches-a-systematic-review-and-meta-analysis
#12
REVIEW
Zhongyu Liu, Xiuli Li, Shuang Tian, Tongyu Zhu, Yuanqing Yao, Ye Tao
OBJECTIVES: To review the safety and effectiveness of da Vinci robotic surgery for cervical cancer in comparison with the traditional open surgery and conventional laparoscopic operation. METHODS: Based on Medline, the Cochrane library, Embase, and the Journal of Robotic Surgery prior to December 30st, 2015, we searched for controlled trials and observational studies. A systematic review with meta-analyses was conducted to compare the clinical efficacy between the da Vinci robotic surgery, open surgery, and laparoscopic surgery for cervical cancer...
February 23, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28238887/coenzyme-a-thioester-formation-of-11-and-15-oxo-eicosatetraenoic-acid
#13
Clementina Mesaros, Alejandro D Arroyo, Ian A Blair, Nathaniel W Snyder
Release of arachidonic acid (AA) by cytoplasmic phospholipase A2 (cPLA2), followed by metabolism through cyclooxygenase-2 (COX-2) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH), results in the formation of the eicosanoids 11-oxo- and 15-oxo-eicosatetraenoic acid (oxo-ETE). Both 11-oxo- and 15-oxo-ETE have been identified in human biospecimens but their function and further metabolism is poorly described. The oxo-ETEs contain an α,β-unsaturated ketone and a free carbocyclic acid, and thus may form Michael adducts with a nucleophile or a thioester with the free thiol of Coenzyme A (CoA)...
February 23, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28238724/proximity-biotinylation-as-a-method-for-mapping-proteins-associated-with-mtdna-in-living-cells
#14
Shuo Han, Namrata D Udeshi, Thomas J Deerinck, Tanya Svinkina, Mark H Ellisman, Steven A Carr, Alice Y Ting
A recurring challenge in cell biology is to define the molecular components of macromolecular complexes of interest. The predominant method, immunoprecipitation, recovers only strong interaction partners that survive cell lysis and repeated detergent washes. We explored peroxidase-catalyzed proximity biotinylation, APEX, as an alternative, focusing on the mitochondrial nucleoid, the dynamic macromolecular complex that houses the mitochondrial genome. Via 1-min live-cell biotinylation followed by quantitative, ratiometric mass spectrometry, we enriched 37 nucleoid proteins, seven of which had never previously been associated with the nucleoid...
February 20, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28237932/effects-of-concurrent-and-delayed-visual-feedback-on-motor-memory-consolidation
#15
Dangxiao Wang, Teng Li, Gaofeng Yang, Yuru Zhang
In many domains, it's important to understand the ways in which humans learn and develop new motor skills effectively and efficiently. For example, in dental operations, the ability to apply a weak force with a required tolerance is a fundamental skill to ensure diagnostic and treatment outcome, but acquiring such a skill is a challenge for novices. In this paper, we focus on motor memory for producing normally applied force by a hand-held probe and we compare the effects of two feedback methods on motor memory consolidation...
February 22, 2017: IEEE Transactions on Haptics
https://www.readbyqxmd.com/read/28237925/hep-2-specimen-image-segmentation-and-classification-using-very-deep-fully-convolutional-network
#16
Yuexiang Li, Linlin Shen, Shiqi Yu
Reliable identification of Human Epithelial-2 (HEp-2) cell patterns can facilitate the diagnosis of systemic autoimmune diseases. However, traditional approach requires experienced experts to manually recognize the cell patterns, which suffers from the inter-observer variability. In this paper, an automatic pattern recognition system using fully convolutional network (FCN) was proposed to simultaneously address the segmentation and classification problem of HEp-2 specimen images. The proposed system transforms the residual network (ResNet) to fully convolutional residual network (FCRN) enabling the network to perform semantic segmentation task...
February 22, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28237785/multi-site-tumor-sampling-msts-a-new-tumor-selection-method-to-enhance-intratumor-heterogeneity-detection
#17
José I López, Jesús M Cortés
Intratumor heterogeneity (ITH) is increasingly being recognized as a highly complex process with high clinical impact that deserves special attention from practicing pathologists. The value of the ITH detection depends on the correctness of the pathologist's sampling. The goal of this review is twofold. On the one hand, we provide a basic scientific context for the practical pathologist's perspective. On the other, we encourage pathologists to adopt a more scientific and up-to-date approach to a key component of their daily work, namely, how to sample a tumor for reliable histological and molecular analysis...
February 22, 2017: Human Pathology
https://www.readbyqxmd.com/read/28237364/an-overview-recycling-of-solid-barley-waste-generated-as-a-by-product-in-distillery-and-brewery
#18
REVIEW
Poonam Singh Nigam
This overview has focused on the options available for the utilisation of residual-biomass generated in distillery and brewery for the production of added-value products. Bio-processing approaches have been reviewed and discussed for the economical bioconversion and utilisation of this waste for the production of bioproducts, such as lactic acid, enzymes, xylitol and animal feed. Though this overview provides several options for the bioprocessing of this residual material, a more suitable one could be chosen according to the processing-facilities available and the amount of residue available in local area...
February 22, 2017: Waste Management
https://www.readbyqxmd.com/read/28237212/value-assessment-at-the-point-of-care-incorporating-patient-values-throughout-care-delivery-and-a-draft-taxonomy-of-patient-values
#19
Melissa J Armstrong, C Daniel Mullins
Incorporation of patient values is a key element of patient-centered care, but consistent incorporation of patient values at the point of care is lacking. Shared decision making encourages incorporation of patient values in decision making, but associated tools often lack guidance on value assessment. In addition, focusing on patient values relating only to specific decisions misses an opportunity for a more holistic approach to value assessment that could impact other aspects of clinical encounters, including health care planning, communication, and stakeholder involvement...
February 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28237197/toward-a-broader-concept-of-value-identifying-and-defining-elements-for-an-expanded-cost-effectiveness-analysis
#20
Louis P Garrison, Sachin Kamal-Bahl, Adrian Towse
This commentary identifies and defines potentially useful expansions to traditional cost-effectiveness analysis as often used in health technology assessment. Since the seminal 1977 article by Weinstein and Stason, the recommended approach has been the use of the incremental cost-effectiveness ratio based on the metric of the cost per quality-adjusted life-year gained, allowing comparisons across different technologies. An expanded framework, incorporating a wider range of the elements of value, is proposed...
February 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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