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https://www.readbyqxmd.com/read/28441672/how-to-lead-the-way-through-complexity-constraint-and-uncertainty-in-academic-health-science-centers
#1
Susan J Lieff, Francis J Yammarino
Academic medicine is in an era of unprecedented and constant change due to fluctuating economies, globalization, emerging technologies, research, and professional and educational mandates. Consequently, academic health science centers (AHSCs) are facing new levels of complexity, constraint, and uncertainty. Currently, AHSC leaders work with competing academic and health service demands and are required to work with and are accountable to a diversity of stakeholders. Given the new challenges and emerging needs, the authors believe the leadership methods and approaches AHSCs have used in the past that led to successes will be insufficient...
May 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28441545/targeted-mass-spectrometry-an-emerging-powerful-approach-to-unblock-the-bottleneck-in-phosphoproteomics
#2
REVIEW
Nerea Osinalde, Kerman Aloria, Miren J Omaetxebarria, Irina Kratchmarova
Following the rapid expansion of the proteomics field, the investigation of post translational modifications (PTM) has become extremely popular changing our perspective of how proteins constantly fine tune cellular functions. Reversible protein phosphorylation plays a pivotal role in virtually all biological processes in the cell and it is one the most characterized PTM up to date. During the last decade, the development of phosphoprotein/phosphopeptide enrichment strategies and mass spectrometry (MS) technology has revolutionized the field of phosphoproteomics discovering thousands of new site-specific phosphorylations and unveiling unprecedented evidence about their modulation under distinct cellular conditions...
April 17, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28441507/new-metrics-for-economic-evaluation-in-the-presence-of-heterogeneity-focusing-on-evaluating-policy-alternatives-rather-than-treatment-alternatives
#3
David D Kim, Anirban Basu
BACKGROUND: Cost-effectiveness analysis (CEA) methods fail to acknowledge that where cost-effectiveness differs across subgroups, there may be differential adoption of technology. Also, current CEA methods are not amenable to incorporating the impact of policy alternatives that potentially influence the adoption behavior. Unless CEA methods are extended to allow for a comparison of policies rather than simply treatments, their usefulness to decision makers may be limited. METHODS: We conceptualize new metrics, which estimate the realized value of technology from policy alternatives, through introducing subgroup-specific adoption parameters into existing metrics, incremental cost-effectiveness ratios (ICERs) and Incremental Net Monetary Benefits (NMBs)...
April 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28441309/trends-complications-and-costs-for-hospital-admission-and-surgery-for-lumbar-spinal-stenosis
#4
Gustavo C Machado, Chris G Maher, Paulo H Ferreira, Ian A Harris, Richard A Deyo, Damien McKay, Qiang Li, Manuela L Ferreira
STUDY DESIGN: Population based health record linkage study. OBJECTIVE: To determine trends in hospital admissions and surgery for lumbar spinal stenosis, as well as complications and resource use in Australia. SUMMARY OF BACKGROUND DATA: In the United States, rates of decompression surgery have declined, whereas those of fusion have increased. It is unclear whether this trend is also happening elsewhere. METHODS: We included patients 18 years and older admitted to a hospital in New South Wales between 2003-2013, who were diagnosed with lumbar spinal stenosis...
April 24, 2017: Spine
https://www.readbyqxmd.com/read/28440718/problematizing-the-concept-of-the-borderline-group-in-performance-assessments
#5
Matt Homer, Godfrey Pell, Richard Fuller
INTRODUCTION: Many standard setting procedures focus on the performance of the "borderline" group, defined through expert judgments by assessors. In performance assessments such as Objective Structured Clinical Examinations (OSCEs), these judgments usually apply at the station level. METHODS AND RESULTS: Using largely descriptive approaches, we analyze the assessment profile of OSCE candidates at the end of a five year undergraduate medical degree program to investigate the consistency of the borderline group across stations...
May 2017: Medical Teacher
https://www.readbyqxmd.com/read/28440344/toxicogenomic-module-associations-with-pathogenesis-a-network-based-approach-to-understanding-drug-toxicity
#6
J J Sutherland, Y W Webster, J A Willy, G H Searfoss, K M Goldstein, A R Irizarry, D G Hall, J L Stevens
Despite investment in toxicogenomics, nonclinical safety studies are still used to predict clinical liabilities for new drug candidates. Network-based approaches for genomic analysis help overcome challenges with whole-genome transcriptional profiling using limited numbers of treatments for phenotypes of interest. Herein, we apply co-expression network analysis to safety assessment using rat liver gene expression data to define 415 modules, exhibiting unique transcriptional control, organized in a visual representation of the transcriptome (the 'TXG-MAP')...
April 25, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/28439999/cost-effectiveness-of-introducing-a-nursing-based-programme-of-ultrasound-guided-peripheral-venous-access-in-a-regional-teaching-hospital
#7
Émilie Gosselin, Johanne Lapré, Stéphan Lavoie, Stéphane Rhein
AIM: To analyse the cost-effectiveness of care provided to patients in need of peripheral venous access by comparing the traditional approach with a nurse-based ultrasound-guided programme. BACKGROUND: Letting nurses insert ultrasound-guided catheters is a promising cost-saving approach, but there are few data available to document the efficiency of this type of programme. METHOD: A cost-efficiency evaluative research design was used. Data were collected over a 6-year timeframe, before and after the implementation of the nurse-based programme...
April 25, 2017: Journal of Nursing Management
https://www.readbyqxmd.com/read/28439758/molecular-phylogeny-of-21-tropical-bamboo-species-reconstructed-by-integrating-non-coding-internal-transcribed-spacer-its1-and-2-sequences-and-their-consensus-secondary-structure
#8
Jayadri Sekhar Ghosh, Samik Bhattacharya, Amita Pal
The unavailability of the reproductive structure and unpredictability of vegetative characters for the identification and phylogenetic study of bamboo prompted the application of molecular techniques for greater resolution and consensus. We first employed internal transcribed spacer (ITS1, 5.8S rRNA and ITS2) sequences to construct the phylogenetic tree of 21 tropical bamboo species. While the sequence alone could grossly reconstruct the traditional phylogeny amongst the 21-tropical species studied, some anomalies were encountered that prompted a further refinement of the phylogenetic analyses...
April 24, 2017: Genetica
https://www.readbyqxmd.com/read/28439263/microbial-diversity-of-browning-peninsula-eastern-antarctica-revealed-using-molecular-and-cultivation-methods
#9
Sarita Pudasaini, John Wilson, Mukan Ji, Josie van Dorst, Ian Snape, Anne S Palmer, Brendan P Burns, Belinda C Ferrari
Browning Peninsula is an ice-free polar desert situated in the Windmill Islands, Eastern Antarctica. The entire site is described as a barren landscape, comprised of frost boils with soils dominated by microbial life. In this study, we explored the microbial diversity and edaphic drivers of community structure across this site using traditional cultivation methods, a novel approach the soil substrate membrane system (SSMS), and culture-independent 454-tag pyrosequencing. The measured soil environmental and microphysical factors of chlorine, phosphate, aspect and elevation were found to be significant drivers of the bacterial community, while none of the soil parameters analyzed were significantly correlated to the fungal community...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28439124/characterisation-of-a-cell-free-synthesised-g-protein-coupled-receptor
#10
Patrick J Shilling, Fabian Bumbak, Daniel J Scott, Ross A D Bathgate, Paul R Gooley
G-protein coupled receptors are the largest family of integral membrane proteins found within the human genome. They function as receptors and modulators to a wide range of ligands and responses which are crucial for human health. GPCR study, specifically the investigation of structure and interaction to cognate ligands, is of high priority. Limitations for structural study can be traced in part, to obtaining suitable quantities of recombinant protein. We sought to address the limitations of traditional recombinant technologies by utilising an Escherichia coli based cell-free protein synthesis (CFPS) approach for production of a thermostable neurotensin receptor 1 (en2NTS1)...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28438970/the-severity-of-vestibular-dysfunction-in-deafness-as-a-determinant-of-comorbid-hyperactivity-or-anxiety
#11
Michelle W Antoine, Sarath Vijayakumar, Nicholas McKeehan, Sherri M Jones, Jean M Hébert
Attention-deficit/hyperactivity disorder (ADHD) and anxiety-related disorders occur at rates 2-3 times higher in deaf compared with hearing children. Potential explanations for these elevated rates and the heterogeneity of behavioral disorders associated with deafness have usually focused on socio-environmental rather than biological effects. Children with the 22q11.2 deletion or duplication syndromes often display hearing loss and behavioral disorders including ADHD and anxiety-related disorders. Here, we show that mouse mutants with either a gain- or loss-of-function of the T-Box transcription factor gene, Tbx1, which lies within the 22q11...
April 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28438483/what-role-does-rheumatoid-arthritis-disease-activity-have-in-cardiovascular-risk
#12
Marco Aurelio Ramírez Huaranga, María Dolores Mínguez Sanchez, Miguel Ángel Zarca Diaz de la Espina, Pedro José Espinoza Pardos, Guillermo Romero Aguilera
Rheumatoid arthritis (RA) is associated with a 1.3 to 3-fold increase in mortality, being the major cause of death from cardiovascular complications (40%-50%). Therefore, the initial approach should include cardiovascular risk (CVR) assessment using algorithms adapted for this population. Although, SCOREM is an important advance, there are data indicating that subclinical atherosclerosis may be underdiagnosed. OBJECTIVE: To estimate the strength of association between carotid ultrasound and SCOREM in this population, as well as the implication of disease activity...
April 21, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28438262/hair-follicle-transplant-into-chronic-ulcers-a-new-graft-concept
#13
M L Martínez Martínez, E Escario Travesedo, F Jiménez Acosta
Chronic venous leg ulcers are a major therapeutic challenge in clinical practice, and the search for new approaches to improve wound healing is essential. Many ulcers do not heal with traditional treatment using compression, debridement, and dressings. Skin-grafts variants, such as pinch grafts, punch grafts, split- or full-thickness skin grafts, and grafts derived from cells cultured in the laboratory, are among the most widely used options in ulcers that do not heal. In recent years, numerous studies have brought to our attention the important role of the hair follicle in the healing process of cutaneous wounds...
April 21, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28438028/cardiac-rehabilitation-programme-as-a-non-pharmacological-platelet-inhibitory-tool-in-acute-coronary-syndrome-survivors
#14
Emese Tóth-Zsámboki, Zsófia Horváth, László Hajtman, Sarolta Leé, Éva Pállinger, Eszter Kuklis, Ádám Tahy, György Fekete, László Kohut, Róbert G Kiss
Background Acute coronary syndrome is associated with platelet hyperactivity, which in its persistent form, promotes recurrent thrombotic events. Complex cardiac rehabilitation after acute coronary syndrome improves clinical outcome; however, its effect on platelet hyperactivity is unknown. Design and methods We enrolled 84 acute coronary syndrome patients on dual antiplatelet therapy, who underwent a new complex cardiac rehabilitation programme (NovaCord physiotherapy, lifestyle counselling, strict diet, stress management and regular coaching) and 51 control acute coronary syndrome patients with traditional cardiac rehabilitation...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28437848/inferring-network-structure-in-non-normal-and-mixed-discrete-continuous-genomic-data
#15
Anindya Bhadra, Arvind Rao, Veerabhadran Baladandayuthapani
Inferring dependence structure through undirected graphs is crucial for uncovering the major modes of multivariate interaction among high-dimensional genomic markers that are potentially associated with cancer. Traditionally, conditional independence has been studied using sparse Gaussian graphical models for continuous data and sparse Ising models for discrete data. However, there are two clear situations when these approaches are inadequate. The first occurs when the data are continuous but display non-normal marginal behavior such as heavy tails or skewness, rendering an assumption of normality inappropriate...
April 24, 2017: Biometrics
https://www.readbyqxmd.com/read/28437546/root-cause-analysis-and-actions-for-the-prevention-of-medical-errors-quality-improvement-and-resident-education
#16
Ryan Charles, Brandon Hood, Joseph M DeRosier, John W Gosbee, James P Bagian, Ying Li, Michelle S Caird, J Sybil Biermann, Mark E Hake
The quality of care delivered by orthopedic surgeons continues to grow in importance. Multiple orthopedic programs, organizations, and committees have been created to measure the quality of surgical care and reduce the incidence of medical adverse events. Structured root cause analysis and actions (RCA2) has become an area of interest. If performed thoroughly, RCA2 has been shown to reduce surgical errors across many subspecialties. The Accreditation Council for Graduate Medical Education has a new mandate for programs to involve residents in quality improvement processes...
April 24, 2017: Orthopedics
https://www.readbyqxmd.com/read/28437354/complete-spondylectomy-using-orthogonal-spinal-fixation-and-combined-anterior-and-posterior-approaches-for-thoracolumbar-spinal-reconstruction-technical-nuances-and-clinical-results
#17
Hasan A Zaidi, Al-Wala Awad, Curtis A Dickman
STUDY DESIGN: Retrospective chart review. OBJECTIVE: To determine the long-term efficacy of 2-stage total en bloc spondylectomy (TES). SUMMARY OF BACKGROUND DATA: TES is a well-described technique to achieve tumor-free margins, but it is a highly destabilizing procedure that necessitates spinal reconstruction. A 2-stage anterior/posterior approach for tumor resection and instrumentation has been shown to be biomechanically superior to the single-stage approach in achieving rigid fixation, but few clinical studies with long-term outcomes exist...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28437024/photon-pair-generation-with-a-100-nm-thick-carbon-nanotube-film
#18
Kim Fook Lee, Ying Tian, He Yang, Kimmo Mustonen, Amos Martinez, Qing Dai, Esko I Kauppinen, John Malowicki, Prem Kumar, Zhipei Sun
Nonlinear optics based on bulk materials is the current technique of choice for quantum-state generation and information processing. Scaling of nonlinear optical quantum devices is of significant interest to enable quantum devices with high performance. However, it is challenging to scale the nonlinear optical devices down to the nanoscale dimension due to relatively small nonlinear optical response of traditional bulk materials. Here, correlated photon pairs are generated in the nanometer scale using a nonlinear optical device for the first time...
April 24, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28436914/a-time-variant-log-linear-learning-approach-to-the-set-k-cover-problem-in-wireless-sensor-networks
#19
Changhao Sun
Toward the global optimality of the SET K-COVER problem in wireless sensor networks, we view each sensor node as a rational player and propose a time variant log-linear learning algorithm (TVLLA) that relies on local information only. By defining the local utility as the normalized area covered by one node alone, we formulate the problem as a spatial potential game. The resulting optimal Nash equilibria correspond to the optimal partition. Such equilibria are obtained by designing a time varying parameter β that approaches infinity with time...
April 19, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28436898/extended-polynomial-growth-transforms-for-design-and-training-of-generalized-support-vector-machines
#20
Ahana Gangopadhyay, Oindrila Chatterjee, Shantanu Chakrabartty
Growth transformations constitute a class of fixed-point multiplicative update algorithms that were originally proposed for optimizing polynomial and rational functions over a domain of probability measures. In this paper, we extend this framework to the domain of bounded real variables which can be applied towards optimizing the dual cost function of a generic support vector machine (SVM). The approach can, therefore, not only be used to train traditional soft-margin binary SVMs, one-class SVMs, and probabilistic SVMs but can also be used to design novel variants of SVMs with different types of convex and quasi-convex loss functions...
April 17, 2017: IEEE Transactions on Neural Networks and Learning Systems
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