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https://www.readbyqxmd.com/read/28239906/complementary-medicine-for-treatment-of-agitation-and-delirium-in-older-persons-a-systematic-review-and-narrative-synthesis
#1
REVIEW
Ilana Levy, Samuel Attias, Eran Ben-Arye, Boaz Bloch, Elad Schiff
BACKGROUND: Agitation and delirium frequently occur in cognitively impaired older people. We conducted a systematic review with narrative synthesis of the literature aiming to assess effectiveness of complementary and alternative medicine (CAM) modalities to address these conditions. METHODS: Following preliminary search, we included 40 original researches on CAM treatment of delirium and agitation in older persons. Then, the quality of these studies was assessed using the Downs and Black Checklist and Quality Assessment Tool for Studies with Diverse Designs, and the effect sizes were calculated...
February 26, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28239654/flow-virometric-sorting-and-analysis-of-hiv-quasispecies-from-plasma
#2
Thomas Musich, Jennifer C Jones, Brandon F Keele, Lisa M Miller Jenkins, Thorsten Demberg, Thomas S Uldrick, Robert Yarchoan, Marjorie Robert-Guroff
Flow cytometry is utilized extensively for cellular analysis, but technical limitations have prevented its routine application for characterizing virus. The recent introduction of nanoscale fluorescence-activated cytometric cell sorting now allows analysis of individual virions. Here, we demonstrate staining and sorting of infectious HIV. Fluorescent antibodies specific for cellular molecules found on budding virions were used to label CCR5-tropic Bal HIV and CXCR4-tropic NL4.3 HIV Env-expressing pseudovirions made in THP-1 cells (monocyte/macrophage) and H9 cells (T cells), respectively...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28239295/can-a-person-centred-care-intervention-improve-health-related-quality-of-life-in-patients-with-head-and-neck-cancer-a-randomized-controlled-study
#3
Elisabeth Hansson, Eric Carlström, Lars-Eric Olsson, Jan Nyman, Ingalill Koinberg
BACKGROUND: The incidence of head and neck cancer is increasing slightly. Head and neck cancer but also it's necessary and often successful treatment may affect general domains of health-related quality of life and provoke a variety of adverse symptoms and side effects, both during and after treatment. The objective of this study was to compare a person-centred care intervention in terms of health-related quality of life, disease-specific symptoms or problems, with traditional care as a control group for patients with head and neck cancer...
2017: BMC Nursing
https://www.readbyqxmd.com/read/28238423/a-computational-algorithm-for-classifying-step-and-spin-turns-using-pelvic-center-of-mass-trajectory-and-foot-position
#4
Pawel R Golyski, Brad D Hendershot
Transient changes in direction during ambulation are typically performed using a step (outside) or spin (inside) turning strategy, often identified through subjective and time-consuming visual rating. Here, we present a computational, marker-based classification method utilizing pelvic center of mass (pCOM) trajectory and time-distance parameters to quantitatively identify turning strategy. Relative to visual evaluation by three independent raters, sensitivity, specificity, and overall accuracy of the pCOM-based classification method were evaluated for 90-degree turns performed by 3 separate populations (5 uninjured controls, 5 persons with transtibial amputation, and 5 persons with transfemoral amputation); each completed turns using two distinct cueing paradigms (i...
January 30, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28238355/prevalence-contexts-and-correlates-of-child-sexual-abuse-in-cyprus
#5
Eleni Karayianni, Kostas A Fanti, Irene-Anna Diakidoy, Maria-Zoe Hadjicharalambous, Evita Katsimicha
It is well documented that child sexual abuse (CSA) may be one of the major public health problems in the world, especially due to the co-occurrence with other types of abuse and negative developmental outcomes. The aim of the current study was the comprehensive examination of CSA with respect to its prevalence, its contexts of occurrence and its correlates. The sample included 1852 adolescents and young adults (15-25 years old; 441 males), recruited through schools, universities and other youth organizations across Cyprus...
February 18, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28238189/retinal-neurodegeneration-in-patients-with-type-1-diabetes-mellitus-the-role-of-glycemic-variability
#6
Fabiana Picconi, Mariacristina Parravano, Dorina Ylli, Patrizio Pasqualetti, Sara Coluzzi, Ilaria Giordani, Ilaria Malandrucco, Davide Lauro, Fabio Scarinci, Paola Giorno, Monica Varano, Simona Frontoni
AIMS: Recent studies have identified neuroretinal abnormalities in persons affected by diabetes mellitus, before the onset of microvascular alterations. However, the role of glycemic variability (GV) on early retinal neurodegeneration is still not clarified. METHODS: To explore the relationship between glycemic control and neuroretinal characteristics, 37 persons with Type 1 diabetes mellitus (Type 1 DM) divided into two groups with no signs (noRD) and with mild non-proliferative diabetic retinopathy (NPDR) compared to 13 healthy control participants (C) were recruited...
February 25, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28237963/inappropriate-prescribing-among-older-persons-in-primary-care-protocol-for-systematic-review-and-meta-analysis-of-observational-studies
#7
Cia Sin Lee, Tau Ming Liew
INTRODUCTION: Inappropriate prescribing has a significant impact on older persons in primary care. Previous reviews on inappropriate prescribing included a heterogeneous range of populations and may not be generalisable to primary care. In this study we aim to conduct a comprehensive systematic review and meta-analysis of the prevalence, risk factors and adverse outcome associated with inappropriate prescribing, specifically among older persons in primary care. METHODS AND ANALYSIS: We will search PubMed, Embase, CINAHL, Web of Science, Scopus, PsycINFO and references of other review articles for observational studies related to the keywords 'older persons', 'primary care' and 'inappropriate prescribing'...
February 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28237917/detection-of-motor-impairment-in-parkinson-s-disease-via-mobile-touchscreen-typing
#8
Teresa Arroyo-Gallego, Maria Jesus Ledesma-Carbayo, Alvaro Sanchez-Ferro, Ian Butterworth, Carlos Sanchez-Mendoza, Michele Matarazzo, Paloma Montero, Roberto Lopez-Blanco, Veronica Puertas-Martin, Rocio Trincado, Luca Giancardo
Mobile technology is opening a wide range of opportunities for transforming the standard of care for chronic disorders. Using smartphones as tools for longitudinally tracking symptoms could enable personalization of drug regimens and improve patient monitoring. Parkinson's disease (PD) is an ideal candidate for these tools. At present, evaluation of PD signs requires trained experts to quantify motor impairment in the clinic, limiting the frequency and quality of the information available for understanding the status and progression of the disease...
February 20, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28237406/pharmacogenetics-based-personalized-therapy-levels-of-evidence-and-recommendations-from-the-french-network-of-pharmacogenetics-rnpgx
#9
Nicolas Picard, Jean-Christophe Boyer, Marie-Christine Etienne-Grimaldi, Chantal Barin-Le Guellec, Fabienne Thomas, Marie-Anne Loriot
More than 50 laboratories offer pharmacogenetic testing in France. These tests are restricted to a limited number of indications: prevention of serious adverse drug reactions; choice of most appropriate therapeutic option; dose adjustment for a specific drug. A very small proportion of these tests are mentioned in drug information labeling and the data provided (if any) are generally insufficient to ascertain whether a test is required and if it is useful. This article discusses the rationale for evaluating the performance and clinical usefulness of pharmacogenetics and provides, on behalf of the French national network of pharmacogenetics (RNPGx), three levels of recommendation for testing: essential, advisable, and possibly helpful...
January 30, 2017: Thérapie
https://www.readbyqxmd.com/read/28237212/value-assessment-at-the-point-of-care-incorporating-patient-values-throughout-care-delivery-and-a-draft-taxonomy-of-patient-values
#10
Melissa J Armstrong, C Daniel Mullins
Incorporation of patient values is a key element of patient-centered care, but consistent incorporation of patient values at the point of care is lacking. Shared decision making encourages incorporation of patient values in decision making, but associated tools often lack guidance on value assessment. In addition, focusing on patient values relating only to specific decisions misses an opportunity for a more holistic approach to value assessment that could impact other aspects of clinical encounters, including health care planning, communication, and stakeholder involvement...
February 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28237075/rasch-analysis-indicates-that-the-simple-shoulder-test-is-robust-but-minor-item-modifications-and-attention-to-gender-differences-should-be-considered
#11
Jayaprakash Raman, Joy C MacDermid, David Walton, George S Athwal
STUDY DESIGN: Repeated cross-sectional study. INTRODUCTION: Multiple studies have evaluated the psychometric properties of the Simple Shoulder Test (SST) through traditional methods supporting it as valid and reliable. Since the evidentiary pool supporting the use of the SST has only partially addressed key measurement properties and the development of SST pre-dates the common use of Rasch model, validation of SST has become a necessity to establish as a reliable and valid PRO for shoulder conditions...
February 22, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28237052/retention-in-buprenorphine-treatment-is-associated-with-improved-hcv-care-outcomes
#12
B L Norton, A Beitin, M Glenn, J DeLuca, A H Litwin, C O Cunningham
Persons who inject drugs, most of whom are opioid dependent, comprise the majority of the HCV infected in the United States. As the national opioid epidemic unfolds, increasing numbers of people are entering the medical system to access treatment for opioid use disorder, specifically with buprenorphine. Yet little is known about HCV care in patients accessing buprenorphine-based opioid treatment. We sought to determine the HCV prevalence, cascade of care, and the association between patient characteristics and completion of HCV cascade of care milestones for patients initiating buprenorphine treatment...
April 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28236962/the-effectiveness-and-cost-of-lifestyle-interventions-including-nutrition-education-for-diabetes-prevention-a-systematic-review-and-meta-analysis
#13
Yu Sun, Wen You, Fabio Almeida, Paul Estabrooks, Brenda Davy
BACKGROUND: Type 2 diabetes is a significant public health concern. With the completion of the Diabetes Prevention Program, there has been a proliferation of studies attempting to translate this evidence base into practice. However, the cost, effectiveness, and cost-effectiveness of these adapted interventions is unknown. OBJECTIVE: The purpose of this systematic review was to conduct a comprehensive meta-analysis to synthesize the effectiveness, cost, and cost-effectiveness of lifestyle diabetes prevention interventions and compare effects by intervention delivery agent (dietitian vs non-dietitian) and channel (in-person vs technology-delivered)...
March 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28236780/treating-conduct-disorder-an-effectiveness-and-natural-language-analysis-study-of-a-new-family-centred-intervention-program
#14
Kimberly A Stevens, Prof Kevin Ronan, Gene Davies
This paper reports on a new family-centred, feedback-informed intervention focused on evaluating therapeutic outcomes and language changes across treatment for conduct disorder (CD). The study included 26 youth and families from a larger randomised, controlled trial (Ronan et al., in preparation). Outcome measures reflected family functioning/youth compliance, delinquency, and family goal attainment. First- and last-treatment session audio files were transcribed into more than 286,000 words and evaluated through the Linguistic Inquiry and Word Count Analysis program (Pennebaker et al...
November 27, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28236613/ayurvedic-profiling-of-alzheimer-s-disease
#15
Dale E Bredesen, Rammohan V Rao
Alzheimer's disease (AD) is an age-associated, progressive neurodegenerative disease that is characterized by severe memory loss, personality changes, and an overall decline in cognitive function. The cause of AD is not yet completely defined and efforts to find a cure for it have so far been disappointing. AD is one of the most significant health care problems nationally and globally. Recently, we described a personalized therapeutic approach called metabolic enhancement for neurodegeneration (MEND) that successfully reversed the cognitive decline in patients with early AD...
February 27, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28236558/dosimetry-applications-in-gate-monte-carlo-toolkit
#16
Panagiotis Papadimitroulas
PURPOSE: Monte Carlo (MC) simulations are a well-established method for studying physical processes in medical physics. The purpose of this review is to present GATE dosimetry applications on diagnostic and therapeutic simulated protocols. There is a significant need for accurate quantification of the absorbed dose in several specific applications such as preclinical and pediatric studies. METHODS: GATE is an open-source MC toolkit for simulating imaging, radiotherapy (RT) and dosimetry applications in a user-friendly environment, which is well validated and widely accepted by the scientific community...
February 21, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28236141/effects-of-age-and-location-in-chinese-relative-clauses-processing
#17
Wenguang He, Na Xu, Runqing Ji
Three experiments investigated Chinese relative clause processing with children, youths and elders using sentence-picture matching and self-paced reading methods. In Experiment 1, we found that object-extracted clause were easier to comprehend than subject-extracted clause , and object-modified relative clause (i.e., object-modified subject-extracted clause[Formula: see text]object-modified object-extracted clause) were difficult to comprehend than subject modified relative clause (subject-modified subject-extracted clause[Formula: see text]subject-modified object-extracted clause)...
February 24, 2017: Journal of Psycholinguistic Research
https://www.readbyqxmd.com/read/28236128/socioeconomic-status-and-bone-mineral-density-in-adults-by-race-ethnicity-and-gender-the-louisiana-osteoporosis-study
#18
Y Du, L-J Zhao, Q Xu, K-H Wu, H-W Deng
: Low bone mineral density (BMD) and osteoporosis have become a public health problem. We found that non-Hispanic white, black, and Asian adults with extremely low education and personal income are more likely to have lower BMD. This relationship is gender-specific. These findings are valuable to guide bone health interventions. INTRODUCTION: The evidence is limited regarding the relationship between socioeconomic status (SES) and bone mineral density (BMD) for minority populations in the USA, as well as the relationship between SES and BMD for men...
February 24, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28236121/impact-of-internal-and-external-factors-on-ebc-ph-and-feno-changes-in-humans-following-challenge-with-ethyl-acrylate
#19
F Hoffmeyer, K Sucker, H Berresheim, C Monsé, B Jettkant, A Beine, M Raulf, J Bünger, T Brüning
Acute effects of ethyl acrylate exposure at 5 ppm for 4 h include changes of pH in exhaled breath condensate (EBC-pH) and exhaled nitric oxide (FeNO). So far, few data have been reported for atopic persons or the impact of the exposure conditions on biomarkers, e.g., constant versus variable application of irritants. Nine atopic and eighteen healthy volunteers without bronchial hyperresponsiveness were exposed for 4 h to ethyl acrylate concentrations of 0.05 ppm (sham), 5 ppm (constant concentration), and 0-10 ppm (variable, mean concentration of 5 ppm) in an exposure laboratory...
February 25, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28236064/the-disconnected-shunt-a-window-of-opportunities
#20
Jonathan Roth, Shlomi Constantini
INTRODUCTION: Shunt disconnection (SD), or migration of the distal end to extra-peritoneal tissues, may lead to shunt malfunction or be diagnosed incidentally. We present a systematic approach for treatment options that is tailored to each patient's personalized history, CSF physiology, and distribution (MRI), as well as a careful informed consent process. METHODS: We present two algorithms, for symptomatic and asymptomatic SD. In cases presenting with symptomatic elevated intracranial pressure, a distal shunt revision (DSR), or, in selected patients, an endoscopic third ventriculostomy (ETV), should be performed...
February 24, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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