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https://www.readbyqxmd.com/read/28531819/welfare-consequences-for-people-with-epilepsy-and-their-partners-a-matched-nationwide-study-in-denmark
#1
Poul Jennum, Anne Sabers, Jakob Christensen, Rikke Ibsen, Jakob Kjellberg
PURPOSE: We aimed to evaluate the excess direct and indirect costs associated with epilepsy. METHODS: From the Danish National Patient Registry (1998-2013), we identified people within all ages with an epilepsy diagnosis and matched them to control individuals. Additionally, partners of people with epilepsy were identified, who were compared with control partners. Direct costs included frequencies and costs of hospitalizations and weighted outpatient use according to diagnosis-related group, and specific outpatient costs based on data from the Danish Ministry of Health...
May 12, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28531324/a-vignette-study-of-older-adults-preferences-for-intergenerational-transfers-in-the-context-of-competition-between-grandparents-and-grandchildren-in-rural-china
#2
Zhen Cong, Merril Silverstein
Objectives: The objective of this analysis was to examine older adults' preferences for economic support in the context of competition between grandparents and grandchildren for the middle generation's financial resources in rural China. Specifically, it examined how relative need, lineage, and gender of grandchildren depicted in a vignette were evaluated and how personal characteristics of the evaluators influenced beliefs for which generation should receive more support. Method: The sample consisted of 989 older adults participating in three waves of a longitudinal study in Anhui Province, China...
May 20, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28531317/a-diabetes-pay-for-performance-program-and-the-competing-causes-of-death-among-cancer-survivors-with-type-2-diabetes-in-taiwan
#3
Hui-Min Hsieh, Herng-Chia Chiu, Yi-Ting Lin, Shyi-Jang Shin
Objective: To examine associations between a diabetes pay-for-performance (P4P) program in Taiwan and all-cause of mortality and competing causes of death in cancer survivors with type 2 diabetes. Design: A longitudinal observational intervention and comparison group study design. Setting and participants: Cancer survivors with type 2 diabetes who enrolled in the P4P program compared with survivors who did not participate (non-P4P) under the Taiwan National Health Insurance program...
May 20, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28531224/defining-the-vaccination-window-for-respiratory-syncytial-virus-rsv-using-age-seroprevalence-data-for-children-in-kilifi-kenya
#4
Joyce U Nyiro, Ivy K Kombe, Charles J Sande, James Kipkoech, Patience K Kiyuka, Clayton O Onyango, Patrick K Munywoki, Timothy M Kinyanjui, D James Nokes
BACKGROUND: Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract disease in early life and a target for vaccine prevention. Data on the age-prevalence of RSV specific antibodies will inform on optimizing vaccine delivery. METHODS: Archived plasma samples were randomly selected within age strata from 960 children less than 145 months of age admitted to Kilifi County Hospital pediatric wards between 2007 and 2010. Samples were tested for antibodies to RSV using crude virus IgG ELISA...
2017: PloS One
https://www.readbyqxmd.com/read/28530652/cd34-cells-from-dental-pulp-stem-cells-with-a-zfn-mediated-and-homology-driven-repair-mediated-locus-specific-knock-in-of-an-artificial-%C3%AE-globin-gene
#5
S Chattong, O Ruangwattanasuk, W Yindeedej, A Setpakdee, K Manotham
In humans, mutations in the β-globin gene (HBB) have two important clinical manifestations: β-thalassemia and sickle cell disease. The progress in genome editing and stem cell research may be relevant to the treatment of β-globin-related diseases. In this work, we employed zinc finger nuclease (ZFN)-mediated gene integration of synthetic β-globin cDNA into HBB loci, thus correcting almost all β-globin mutations. The integration was achieved in both HEK 293 cells and isolated dental pulp stem cell (DPSCs)...
May 22, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28530437/developmental-continuity-and-change-in-physical-verbal-and-relational-aggression-and-peer-victimization-from-childhood-to-adolescence
#6
Idean Ettekal, Gary W Ladd
To investigate the developmental course of aggression and peer victimization in childhood and adolescence, distinct subgroups of children were identified based on similarities and differences in their physical, verbal and relational aggression, and victimization. Developmental continuity and change were assessed by examining transitions within and between subgroups from Grades 1 to 11. This longitudinal study consisted of 482 children (50% females) and was based on peer report data on multiple forms of aggression and peer victimization...
May 22, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28530342/-behavioral-physiological-and-morphological-characteristics-associated-with-post-traumatic-response-to-continuous-exposure-versus-alternate-exposure-in-an-animal-model-of-post-traumatic-stress-disorder
#7
Ishay Ostfeld, Zeev Kaplan, Hagit Cohen
AIMS: The aim of this study was to approximate these conditions in an animal model of post-traumatic stress disorder (PTSD). More specifically, the neurobiological basis of these conditions, focusing on stress-related behavioral changes, HPA-axis and morphological were evaluated. The intention was to employ this well-validated, reproducible and reliable model for PTSD, to elicit data which will provide some guidance in the planning of a prospective study involving military personal. BACKGROUND: Combat personnel are exposed to significant stress and hardship, both physical and emotional, during their service and especially during active combat...
December 2016: Harefuah
https://www.readbyqxmd.com/read/28529740/copy-number-variation-and-protein-expression-of-dot1l-in-pancreatic-adenocarcinoma-as-a-potential-drug-target
#8
Heike Loeser, Dirk Waldschmidt, Fabian Kuetting, Carina Heydt, Thomas Zander, Patrick Plum, Hakan Alakus, Reinhard Buettner, Alexander Quaas
Adenocarcinoma of the pancreas has a poor prognosis. At present, no relevant personalized targets have been identified. Sequencing studies have implicated gene alterations of disruptor of telomeric silencing 1 like histone lysine methyltransferase (DOT1L) in pancreatic adenocarcinoma. DOT1L is part of the histone modification system and catalyzes methylation of H3K79, which is crucial in cell signaling and DNA damage repair. DOT1L is considered to be a target of therapy in mixed lineage leukemia gene-deficient leukemia cases and a potential target in breast carcinoma...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28529492/depression-in-men-and-women-one-year-following-traumatic-brain-injury-tbi-a-tbi-model-systems-study
#9
Sarah Lavoie, Samantha Sechrist, Nhung Quach, Reza Ehsanian, Thao Duong, Ian H Gotlib, Linda Isaac
In the general population, females experience depression at significantly higher rates than males. Individuals with traumatic brain injury (TBI) are at substantially greater risk for depression compared to the overall population. Treatment of, and recovery from, TBI can be hindered by depression; comorbid TBI and depression can lead to adverse outcomes and negatively affect multiple aspects of individuals' lives. Gender differences in depression following TBI are not well understood, and relevant empirical findings have been mixed...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28529411/the-electronically-activated-recorder-ear-a-method-for-the-naturalistic-observation-of-daily-social-behavior
#10
Matthias R Mehl
This article reviews the Electronically Activated Recorder or EAR as an ambulatory ecological momentary assessment tool for the real-world observation of daily behavior. Technically, the EAR is an audio recorder that intermittently records snippets of ambient sounds while participants go about their lives. Conceptually, it is a naturalistic observation method that yields an acoustic log of a person's day as it unfolds. The power of the EAR lies in unobtrusively collecting authentic real-life observational data...
April 2017: Current Directions in Psychological Science
https://www.readbyqxmd.com/read/28529236/-all-in-the-day-s-work-cold-war-doctoring-and-its-discontents-in-william-burroughs-s-i-naked-lunch-i
#11
Michael Jarvis
In Naked Lunch, the institutions and practices of science and medicine, specifically with regard to psychiatry/psychology, are symptoms of a bureaucratic system of control that shapes, constructs, defines, and makes procrustean alterations to both the mind and body of human subjects. Using sickness and junk (or heroin) as convenient metaphors for both a Cold War binary mentality and the mandatory consumption of twentieth-century capitalism, Burroughs presents modern man as fundamentally alienated from any sense of a personal self...
2017: Literature and Medicine
https://www.readbyqxmd.com/read/28529224/-i-need-my-own-place-to-get-better-patient-perspectives-on-the-role-of-housing-in-potentially-preventable-hospitalizations
#12
Michelle L Quensell, Deborah A Taira, Todd B Seto, Kathryn L Braun, Tetine L Sentell
OBJECTIVE: To analyze patient perspectives on the role of housing in their potentially preventable hospitalization. METHODS: Individuals admitted with cardiovascular-or diabetes-related diagnoses (n = 90) in a major medical center in Hawai'i completed an in-person interview eliciting patient perspectives on key factors leading to hospitalization. Using the framework approach, two independent coders identified themes. This study focused on housing-related findings...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28529215/innovative-program-delivery-and-determinants-of-frequent-visitation-to-a-mobile-medical-clinic-in-an-urban-setting
#13
Britton A Gibson, Jamie P Morano, Mary R Walton, Ruthanne Marcus, Alexei Zelenev, R Douglas Bruce, Frederick L Altice
The Community Health Care Van (CHCV) is a mobile medical clinic (MMC) that has served vulnerable populations in New Haven, Connecticut since 1993. This study explores utilization patterns to understand if certain populations frequently rely upon non-traditional health care within a representative MMC. Patient characteristics, services used, and visitation frequency were described and compared for 8,415 unique clients making 29,728 visits. Negative binomial regression was used to model the impact of specific indicators on visitation...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28529068/adverse-outcome-pathways-application-to-enhance-mechanistic-understanding-of-neurotoxicity
#14
REVIEW
Anna Bal-Price, M E Meek
Recent developments have prompted the transition of empirically based testing of late stage toxicity in animals for a range of different endpoints including neurotoxicity to more efficient and predictive mechanistically based approaches with greater emphasis on measurable key events early in the progression of disease. The adverse outcome pathway (AOP) has been proposed as a simplified organizational construct to contribute to this transition by linking molecular initiating events and earlier (more predictive) key events at lower levels of biological organization to disease outcomes...
May 18, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28529048/laboratory-based-performance-evaluation-of-pima-cd4-t-lymphocyte-count-point-of-care-by-lay-counselors-in-kenya
#15
Clement Zeh, Charles E Rose, Seth Inzaule, Mitesh A Desai, Fredrick Otieno, Felix Humwa, Benta Akoth, Paul Omolo, Robert T Chen, Yenew Kebede, Taraz Samandri
BACKGROUND: CD4+ T-lymphocyte count testing at the point-of-care (POC) may improve linkage to care of persons diagnosed with HIV-1 infection, but the accuracy of POC devices when operated by lay-counselors in the era of task-shifting is unknown. We examined the accuracy of Alere's Pima™ POC device on both capillary and venous blood when performed by lay-counselors and laboratory technicians. METHODS: In Phase I, we compared the perfomance of POC against FACSCalibur™ for 280 venous specimens by laboratory technicians...
May 18, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28529027/management-of-postneurosurgical-meningitis-narrative-review
#16
REVIEW
Khetam Hussein, Roni Bitterman, Ben Shofty, Mical Paul, Ami Neuberger
BACKGROUND: Infections complicating neurosurgery pose unacceptable mortality and morbidity. AIMS: To summarize what is known about the epidemiology, diagnosis and treatment of post-neurosurgical meningitis (PNM). SOURCES: PubMed, references of identified studies and reviews, and personal experience when evidence was lacking. CONTENT: The incidence and pathogen distribution of PNM is highly variable. A shift towards Gram-negative bacteria has been observed with use of antibiotic prophylaxis and antibiotic-coated devices directed mainly against Gram-positive bacteria...
May 18, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28529006/validation-of-a-next-generation-sequencing-pipeline-for-the-molecular-diagnosis-of-multiple-inherited-cancer-predisposing-syndromes
#17
Paula Paulo, Pedro Pinto, Ana Peixoto, Catarina Santos, Carla Pinto, Patrícia Rocha, Isabel Veiga, Gabriela Soares, Catarina Machado, Fabiana Ramos, Manuel R Teixeira
Despite the growing knowledge of the genetic background behind the cancers that occur in a context of hereditary predisposition, personal or family cancer history may not be clear enough to support directional gene testing. Defined targeted next-generation sequencing gene panels allow identification of the causative disease mutations of multigene syndromes and differential diagnosis for syndromes with phenotypically overlapping characteristics. Herein, we established a next-generation sequencing analysis pipeline for the molecular diagnosis of multiple inherited cancer predisposing syndromes using the commercially available target sequencing panel TruSight Cancer...
May 18, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28528817/tracing-and-characterizing-the-development-of-transplanted-female-germline-stem-cells-in%C3%A2-vivo
#18
Changqing Wu, Bo Xu, Xiaoyong Li, Wenzhi Ma, Ping Zhang, Xuejin Chen, Ji Wu
It has long been believed that most female mammalian species lose the ability to generate oocytes in postnatal ovaries. Recent evidence has demonstrated the isolation and culture of female germline stem cells (FGSCs) from adult mice and humans. However, the process and mechanisms of FGSC differentiation in vivo following transplantation have not yet been studied. Here, we isolated and characterized FGSCs from a single EGFP-transgenic mouse, and traced the development and behavior of transplanted FGSCs (F-TFs) in vivo...
May 6, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28528770/ethnic-variation-in-self-rated-health-mortality-association-results-from-a-17-year-follow-up-study-in-estonia
#19
Rainer Reile, Mall Leinsalu
BACKGROUND AND AIM: Previous research has highlighted the role of self-rated health (SRH) as an important predictor of mortality. With substantial ethnic differences in SRH and mortality reported in Estonia, this study aims to examine the ethnic variation in SRH-mortality association in this setting. MATERIALS AND METHODS: The baseline data come from the nationally representative 1996 Estonian Health Interview Survey. Individual records of 3983 respondents in the 25-79 age group were linked with mortality data with 17 years follow-up time...
May 2, 2017: Medicina
https://www.readbyqxmd.com/read/28528753/healthcare-access-and-quality-index-based-on-mortality-from-causes-amenable-to-personal-health-care-in-195-countries-and-territories-1990-2015-a-novel-analysis-from-the-global-burden-of-disease-study-2015
#20
(no author information available yet)
BACKGROUND: National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). Previous analyses of mortality amenable to health care only focused on high-income countries and faced several methodological challenges. In the present analysis, we use the highly standardised cause of death and risk factor estimates generated through the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) to improve and expand the quantification of personal health-care access and quality for 195 countries and territories from 1990 to 2015...
May 18, 2017: Lancet
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