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https://www.readbyqxmd.com/read/27933566/fracture-incidence-rates-in-norwegian-children-the-troms%C3%A3-study-fit-futures
#1
Tore Christoffersen, Luai A Ahmed, Anne Winther, Ole Andreas Nilsen, Anne-Sofie Furberg, Guri Grimnes, Elaine Dennison, Jacqueline R Center, John A Eisman, Nina Emaus
: This study describes childhood fracture rates in Norway, a country known for high fracture rates in the adult population. Fracture rates correspond with other reports from Scandinavia, although with a slightly higher proportion in girls. Indications of increased vulnerability during stages of puberty require further exploration. INTRODUCTION: Fractures are common injuries during childhood. Incidence rates and patterns vary, but population-based data are scarce...
December 2016: Archives of Osteoporosis
https://www.readbyqxmd.com/read/27933407/simvascular-an-open-source-pipeline-for-cardiovascular-simulation
#2
REVIEW
Adam Updegrove, Nathan M Wilson, Jameson Merkow, Hongzhi Lan, Alison L Marsden, Shawn C Shadden
Patient-specific cardiovascular simulation has become a paradigm in cardiovascular research and is emerging as a powerful tool in basic, translational and clinical research. In this paper we discuss the recent development of a fully open-source SimVascular software package, which provides a complete pipeline from medical image data segmentation to patient-specific blood flow simulation and analysis. This package serves as a research tool for cardiovascular modeling and simulation, and has contributed to numerous advances in personalized medicine, surgical planning and medical device design...
December 8, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27933305/robust-generation-of-transgenic-mice-by-simple-hypotonic-solution-mediated-delivery-of-transgene-in-testicular-germ-cells
#3
Abul Usmani, Nirmalya Ganguli, Subodh K Jain, Nilanjana Ganguli, Rajesh Kumar Sarkar, Mayank Choubey, Mansi Shukla, Hironmoy Sarkar, Subeer S Majumdar
Our ability to decipher gene sequences has increased enormously with the advent of modern sequencing tools, but the ability to divulge functions of new genes have not increased correspondingly. This has caused a remarkable delay in functional interpretation of several newly found genes in tissue and age specific manner, limiting the pace of biological research. This is mainly due to lack of advancements in methodological tools for transgenesis. Predominantly practiced method of transgenesis by pronuclear DNA-microinjection is time consuming, tedious, and requires highly skilled persons for embryo-manipulation...
2016: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/27933200/age-specific-and-sex-specific-incidence-of-systemic-lupus-erythematosus-an-estimate-from-cross-sectional-claims-data-of-2-3-million-people-in-the-german-statutory-health-insurance-2002
#4
Ralph Brinks, Annika Hoyer, Sergej Weber, Rebecca Fischer-Betz, Oliver Sander, Jutta G Richter, Gamal Chehab, Matthias Schneider
OBJECTIVE: To provide an estimate of age-specific incidence rate of physician-diagnosed systemic lupus erythematosus (SLE) for German men and women. METHODS: The age-specific and sex-specific prevalence of diagnosed SLE in claims data is used to estimate the incidence in the German male and female population. The claims data set stems from a representative sample of the statutory health insurance in 2002 and comprises 2.3 million people. The statutory health insurance covers >85% of the German population...
2016: Lupus Science & Medicine
https://www.readbyqxmd.com/read/27933020/feasibility-of-group-schema-therapy-for-outpatients-with-severe-borderline-personality-disorder-in-germany-a-pilot-study-with-three-year-follow-up
#5
Eva Fassbinder, Maren Schuetze, Annika Kranich, Valerija Sipos, Fritz Hohagen, Ida Shaw, Joan Farrell, Arnoud Arntz, Ulrich Schweiger
Borderline Personality Disorder (BPD) is a severe, challenging to treat mental disorder. Schema therapy (ST) as an individual therapy has been proven to be an effective psychological treatment for BPD. A group format of ST (GST) has been developed and evaluated in a randomized controlled trial in the United States and piloted in The Netherlands. These results suggest that GST speeds up and amplifies treatment effects of ST and might reduce delivery costs. However, feasibility in the German health care system and with BPD patients with high BPD severity and comorbidity, and frequent hospitalization, has not been tested to date...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27933017/why-acting-environmentally-friendly-feels-good-exploring-the-role-of-self-image
#6
Leonie A Venhoeven, Jan Willem Bolderdijk, Linda Steg
Recent research suggests that engagement in environmentally-friendly behavior can feel good. Current explanations for such a link do not focus on the nature of environmentally-friendly behavior itself, but rather propose well-being is more or less a side-benefit; behaviors that benefit environmental quality (e.g., spending one's money on people rather than products) also tend to make us feel good. We propose that the moral nature of environmentally-friendly behavior itself may elicit positive emotions as well, because engaging in this behavior can signal one is an environmentally-friendly and thus a good person...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27932932/atlas-of-ohio-aquatic-insects-volume-ii-plecoptera
#7
R Edward DeWalt, Scott A Grubbs, Brian J Armitage, Richard W Baumann, Shawn M Clark, Michael J Bolton
BACKGROUND: We provide volume II of a distributional atlas of aquatic insects for the eastern USA state of Ohio. This treatment of stoneflies (Plecoptera) is companion to Armitage et al. (2011) on caddisflies (Trichoptera). We build on a recent analysis of Ohio stonefly diversity patterns based on large drainages (DeWalt et al. 2012), but add 3717 new records to the data set. We base most analyses on the United States Geological Survey Hierarchical Unit Code eight (HUC8) drainage scale...
2016: Biodiversity Data Journal
https://www.readbyqxmd.com/read/27932553/normalization-matters-tracking-the-best-strategy-for-sperm-mirna-quantification
#8
Celia Corral-Vazquez, Joan Blanco, Albert Salas-Huetos, Francesca Vidal, Ester Anton
STUDY QUESTION: What is the most reliable normalization strategy for sperm microRNA (miRNA) quantitative Reverse Transcription Polymerase Chain Reactions (qRT-PCR) using singleplex assays? SUMMARY ANSWER: The use of the average expression of hsa-miR-100-5p and hsa-miR-30a-5p as sperm miRNA qRT-PCR data normalizer is suggested as an optimal strategy. WHAT IS KNOWN ALREADY: Mean-centering methods are the most reliable normalization strategies for miRNA high-throughput expression analyses...
December 8, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27932365/danish-register-based-study-on-the-association-between-specific-antipsychotic-drugs-and-fractures-in-elderly-individuals
#9
Maia Torstensson, Katja Leth-Møller, Charlotte Andersson, Christian Torp-Pedersen, Gunnar Hilmar Gislason, Ellen Astrid Holm
BACKGROUND: antipsychotic drugs (APs) have been associated with falls and fractures in elderly individuals but limited knowledge on specific drugs exist. OBJECTIVE: to investigate the association between individual APs and fractures in elderly persons. DESIGN AND SETTING: nationwide register-based cohort study. SUBJECTS: all Danish individuals aged ≥65 who had not been in treatment with any AP in the year before inclusion...
December 7, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27931228/internal-living-environment-and-respiratory-disease-in-children-findings-from-the-growing-up-in-new-zealand-longitudinal-child-cohort-study
#10
Sandar Tin Tin, Alistair Woodward, Rajneeta Saraf, Sarah Berry, Polly Atatoa Carr, Susan M B Morton, Cameron C Grant
BACKGROUND: The incidence of early childhood acute respiratory infections (ARIs) has been associated with aspects of the indoor environment. In recent years, public awareness about some of these environmental issues has increased, including new laws and subsequent changes in occupant behaviours. This New Zealand study investigated current exposures to specific risk factors in the home during the first five years of life and provided updated evidence on the links between the home environment and childhood ARI hospitalisation...
December 8, 2016: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/27931197/reaching-the-elderly-understanding-of-health-and-preventive-experiences-for-a-tailored-approach-results-of-a-qualitative-study
#11
Christiane Patzelt, Susanne Heim, Bernhilde Deitermann, Gudrun Theile, Christian Krauth, Eva Hummers-Pradier, Ulla Walter
BACKGROUND: Often preventive measures are not accessed by the people who were intended to be reached. Programs for older adults may target men and women, older adults, advanced old age groups and/or chronically ill patients with specific indications. The defined target groups rarely participate in the conception of programs or in the design of information materials, although this would increase accessibility and participation. In the German "Reaching the Elderly" study (2008-2011), an approach to motivating older adults to participate in a preventive home visit (PHV) program was modified with the participatory involvement of the target groups...
December 8, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27930938/short-forms-of-the-utrecht-management-of-identity-commitments-scale-u-mics-with-the-domains-of-job-romantic-relationship-and-region
#12
Elisabeth Schubach, Julia Zimmermann, Peter Noack, Franz J Neyer
The U-MICS is a self-report questionnaire designed to assess the identity dimensions from a domain-specific perspective. The present study reports on the development of a short-form version for the domains of job and romantic relationship in young adults from Germany and extends this scale to include the domain of region (nSample1 = 95, 84% female, mean age 22.45 years; nSample2 = 1,795, 71% female, mean age 24.53 years). We found the short form to possess adequate psychometric properties and to demonstrate a factor structure congruent to the long-form version...
December 5, 2016: Journal of Adolescence
https://www.readbyqxmd.com/read/27930914/a-high-fat-diet-induced-decrease-in-hippocampal-newly-born-neurons-of-male-mice-is-exacerbated-by-mild-psychological-stress-using-a-communication-box
#13
Yusuke Murata, Yukiyasu Narisawa, Rima Shimono, Hiraku Ohmori, Masayoshi Mori, Kenji Ohe, Kazunori Mine, Munechika Enjoji
BACKGROUND: Obese persons have a higher incidence of depression than healthy-weight persons. Several studies indicated that the exposure to a high fat diet (HFD) results in a decrease in hippocampal neurogenesis, which leads to higher stress response and stress-induced depression. Although stress is a risk factor for obesity and depression, no studies to date have investigated the effect of stress on the hippocampal neurogenesis of HFD-induced obese animals. The aim of this study was to elucidate whether or not obese HFD-fed mice are vulnerable to stress-induced depression by investigating hippocampal neurogenesis...
November 30, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27930662/methods-for-developing-evidence-reviews-in-short-periods-of-time-a-scoping-review
#14
Ahmed M Abou-Setta, Maya Jeyaraman, Abdelhamid Attia, Hesham G Al-Inany, Mauricio Ferri, Mohammed T Ansari, Chantelle M Garritty, Kenneth Bond, Susan L Norris
INTRODUCTION: Rapid reviews (RR), using abbreviated systematic review (SR) methods, are becoming more popular among decision-makers. This World Health Organization commissioned study sought to summarize RR methods, identify differences, and highlight potential biases between RR and SR. METHODS: Review of RR methods (Key Question 1 [KQ1]), meta-epidemiologic studies comparing reliability/ validity of RR and SR methods (KQ2), and their potential associated biases (KQ3)...
2016: PloS One
https://www.readbyqxmd.com/read/27930611/community-mobilization-for-hiv-testing-uptake-results-from-a-community-randomized-trial-of-a-theory-based-intervention-in-rural-south-africa
#15
Sheri A Lippman, Torsten B Neilands, Catherine MacPhail, Dean Peacock, Suzanne Maman, Dumisani Rebombo, Rhian Twine, Amanda Selin, Hannah H Leslie, Kathleen Kahn, Audrey Pettifor
BACKGROUND: HIV testing uptake in South Africa is below optimal levels. Community mobilization (CM) may increase and sustain demand for HIV testing, however, little rigorous evidence exists regarding the effect of CM interventions on HIV testing and the mechanisms of action. METHODS: We implemented a theory-driven CM intervention in 11 of 22 randomly-selected villages in rural Mpumalanga Province. Cross-sectional surveys including a community mobilization measure were conducted before (n = 1181) and after (n = 1175) a 2-year intervention (2012-2014)...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27930590/low-mortality-but-increasing-incidence-of-staphylococcus-aureus-endocarditis-in-people-who-inject-drugs-experience-from-a-swedish-referral-hospital
#16
Hilmir Asgeirsson, Anders Thalme, Ola Weiland
Staphylococcus aureus is a leading cause of infective endocarditis in people who inject drugs (PWID). The management of S aureus endocarditis (SAE) in PWID can be problematic. The objective of this retrospective observational study was to assess the epidemiology, clinical characteristics, and mortality of S aureus endocarditis (SAE) in PWID in Stockholm, Sweden.The Department of Infectious Diseases at the Karolinska University Hospital serves as a regional referral center for drug users with severe infections...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930512/religious-stigmata-as-malingering-artifact-report-of-a-case-and-review-of-the-literature
#17
Domenico Bonamonte, Michelangelo Vestita, Angela Filoni, Giuseppe Giudice, Gianni Angelini
RATIONALE: Artifacts or simulated diseases are self-inflicted conditions caused by various means and for different purposes. Disease simulation can be motivated, among other things, by illegal purposes, to escape from civil duties or prison sentences, for example, or to exploit specific situations in order to receive a range of benefits. In such cases, the simulator is fully aware of his or her actions and intentions. DIAGNOSES, INTERVENTIONS AND OUTCOMES: We report the case of a 42-year-old woman who, for 3 consecutive years, showed religious stigmata on the forehead and on the dorsal surface of hands and feet immediately before Easter...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27929247/initial-management-of-patients-with-hiv-infection
#18
Ronald H Goldschmidt, Carolyn Chu, Betty J Dong
Human immunodeficiency virus (HIV) infection has become a treatable chronic disease with near-normal life expectancy when patients receive antiretroviral therapy (ART). Family physicians and other primary care clinicians commonly provide long-term comprehensive care for persons with HIV infection. This article describes the scope of initial care, including obtaining a thorough history; physical examination for HIV-associated manifestations; attention to HIV-specific immunization schedules; routine and HIV-specific laboratory evaluation; and ensuring standard health care maintenance to prevent HIV- and non-HIV-related morbidity and mortality...
November 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27929232/the-pretravel-consultation
#19
Christopher Sanford, Adam McConnell, Justin Osborn
Key components of the pretravel consultation include intake questions regarding the traveler's anticipated itinerary and medical history; immunizations; malaria prophylaxis; and personal protection measures against arthropod bites, traveler's diarrhea, and injury. Most vaccinations that are appropriate for international travelers are included in the routine domestic immunization schedule; only a few travel-specific vaccines must also be discussed. The most common vaccine-preventable illnesses in international travelers are influenza and hepatitis A...
October 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/27929079/from-function-to-phenotype-impaired-dna-binding-and-clustering-correlates-with-clinical-severity-in-males-with-missense-mutations-in-mecp2
#20
Taimoor I Sheikh, Juan Ausió, Hannah Faghfoury, Josh Silver, Jane B Lane, James H Eubanks, Patrick MacLeod, Alan K Percy, John B Vincent
Mutations in the MECP2 gene cause Rett syndrome (RTT). MeCP2 binds to chromocentric DNA through its methyl CpG-binding domain (MBD) to regulate gene expression. In heterozygous females the variable phenotypic severity is modulated by non-random X-inactivation, thus making genotype-phenotype comparisons unreliable. However, genotype-phenotype correlations in males with hemizygousMECP2 mutations can provide more accurate insights in to the true biological effect of specific mutations. Here, we compared chromatin organization and binding dynamics for twelve MeCP2 missense mutations (including two novel and the five most common MBD missense RTT mutations) and identifiedacorrelation with phenotype in hemizygous males...
December 8, 2016: Scientific Reports
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