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https://www.readbyqxmd.com/read/28487705/genome-wide-association-mapping-reveals-multiple-qtls-governing-tolerance-response-for-seedling-stage-chilling-stress-in-indica-rice
#1
Elssa Pandit, Swaleha Tasleem, Saumya R Barik, Durga P Mohanty, Deepak K Nayak, Shakti P Mohanty, Sujata Das, Sharat K Pradhan
Rice crop is sensitive to cold stress at seedling stage. A panel of population representing 304 shortlisted germplasm lines was studied for seedling stage chilling tolerance in indica rice. Six phenotypic classes were exposed to six low temperature stress regimes under control phenotyping facility to investigate response pattern. A panel of 66 genotypes representing all phenotypic classes was used for ensuring genetic diversity, population structure and association mapping for the trait using 58 simple sequence repeat (SSR) and 2 direct trait linked markers...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28477017/characterization-of-potential-driver-mutations-involved-in-human-breast-cancer-by-computational-approaches
#2
REVIEW
Barani Kumar Rajendran, Chu-Xia Deng
Breast cancer is the second most frequently occurring form of cancer and is also the second most lethal cancer in women worldwide. A genetic mutation is one of the key factors that alter multiple cellular regulatory pathways and drive breast cancer initiation and progression yet nature of these cancer drivers remains elusive. In this article, we have reviewed various computational perspectives and algorithms for exploring breast cancer driver mutation genes. Using both frequency based and mutational exclusivity based approaches, we identified 195 driver genes and shortlisted 63 of them as candidate drivers for breast cancer using various computational approaches...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28473483/antibiotic-awareness-poster-makes-awards-shortlist
#3
(no author information available yet)
No abstract text is available yet for this article.
May 6, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28470390/biallelic-mutations-in-cyp24a1-or-slc34a1-as-a-cause-of-infantile-idiopathic-hypercalcemia-iih-with-vitamin-d-hypersensitivity-molecular-study-of-11-historical-iih-cases
#4
Ewa Pronicka, Elżbieta Ciara, Paulina Halat, Agnieszka Janiec, Marek Wójcik, Elżbieta Rowińska, Dariusz Rokicki, Paweł Płudowski, Ewa Wojciechowska, Aldona Wierzbicka, Janusz B Książyk, Agnieszka Jacoszek, Martin Konrad, Karl P Schlingmann, Mieczysław Litwin
Idiopathic infantile hypercalcemia (IIH) is a mineral metabolism disorder characterized by severe hypercalcemia, failure to thrive, vomiting, dehydration, and nephrocalcinosis. The periodical increase in incidence of IIH, which occurred in the twentieth century in the United Kingdom, Poland, and West Germany, turned out to be a side effect of rickets over-prophylaxis. It was recently discovered that the condition is linked to two genes, CYP24A1 and SLC34A1. The aim of the study was to search for pathogenic variants of the genes in adult persons who were shortlisted in infancy as IIH caused by "hypersensitivity to vit...
May 3, 2017: Journal of Applied Genetics
https://www.readbyqxmd.com/read/28365592/cell-scientist-to-watch-victoria-sanz-moreno
#5
(no author information available yet)
Vicky Sanz-Moreno received her first degree in chemistry and later a master's degree in biochemistry from the University of Oviedo in Spain, followed by a PhD in chemical sciences in the laboratory of Piero Crespo at the University of Cantabria, awarded in 2002. After a short postdoc in the same lab funded by a Lady Tata Memorial Trust Fellowship, she moved to the Institute of Cancer Research in London as a CRUK and Marie Curie Intra-European Fellow to work with Chris Marshall. In 2008, she received the Applied Biosystems and EACR 40th Anniversary Research Award...
April 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28351255/five-worthy-finalists-for-our-patient-s-choice-award
#6
(no author information available yet)
The RCNi Nurse Awards are not only the most prestigious accolades in nursing, they are also the only awards that give patients the opportunity to choose their own nurse of the year. This week we reveal the shortlist for the 2017 RCNi Patient's Choice award, and choosing between the final five will be as challenging as ever.
March 29, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28351241/who-will-be-this-year-s-patient-s-choice
#7
(no author information available yet)
Our five Patient's Choice finalists have been shortlisted from scores of nominations. The award, sponsored by Yakult, enables members of the public to thank a nurse or midwife who has made a real difference to their care or that of a loved one. Smooth Radio and Good Morning Britain presenter Kate Garraway will announce the winner at the RCNi Nurse Awards ceremony in London on 5 May. RCNi editorial director Graham Scott says: 'Here are five inspirational nurses and five examples of outstanding care that all deserve an award...
March 29, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28340318/is-there-a-relationship-between-postural-alignment-and-mobility-for-adults-after-acquired-brain-injury-a-systematic-review
#8
Simon J Mills, Michelle N McDonnell, Dominic Thewlis, Shylie Mackintosh
PRIMARY OBJECTIVE: To examine the relationship between postural alignment and mobility skills for adults after acquired brain injury (ABI). METHODS: Systematic review of the literature. Seven electronic databases, grey literature and reference lists of the shortlisted publications were searched. Studies were included if participants were adults with ABI, both postural alignment and mobility were measured and analysis included a relationship between alignment and mobility...
March 24, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28330176/molecular-dissection-of-pathway-components-unravel-atisine-biosynthesis-in-a-non-toxic-aconitum-species-a-heterophyllum-wall
#9
Varun Kumar, Nikhil Malhotra, Tarun Pal, Rajinder Singh Chauhan
Aconitum heterophyllum is an important component for various herbal drug formulations due to the occurrence of non-toxic aconites including marker compound, atisine. Despite huge pharmacological potential, the reprogramming of aconites production is limited due to lack of understanding on their biosynthesis. To address this problem, we have proposed here the complete atisine biosynthetic pathway for the first time connecting glycolysis, MVA/MEP, serine biosynthesis and diterpene biosynthetic pathways. The transcript profiling revealed phosphorylated pathway as a major contributor towards serine production in addition to repertoire of genes in glycolysis (G6PI, PFK, ALD and ENO), serine biosynthesis (PGDH and PSAT) and diterpene biosynthesis (KO and KH) sharing a similar pattern of expression (2-4-folds) in roots compared to shoots vis-à-vis atisine content (0-0...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28327008/shortlist-revealed-for-patient-s-choice-category
#10
(no author information available yet)
Voting is now open for the Patient's Choice category of the RCNi Nurse Awards 2017.
March 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28273037/status-report-identifying-equity-focussed-interventions-to-promote-healthy-weights
#11
C James Frankish, Brenda Kwan, Diane E Gray, Andrea Simpson, Nina Jetha
INTRODUCTION: We developed screening criteria to identify population health interventions with an equity focus for inclusion on the Public Health Agency of Canada's Canadian Best Practices Portal. We applied them to the area of "healthy weights," specifically, obesity prevention. METHODS: We conducted a review of the literature and obtained input from expert external reviewers on changes to midstream environments. Interventions had to identify outcomes for groups with an underlying social disadvantage...
March 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/28262059/child-health-category-shortlist-revealed
#12
(no author information available yet)
Finalists for the child health award at the RCNi Nurse Awards 2017 have been revealed.
March 6, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/28250587/bread-wheat-progenitors-aegilops-tauschii-dd-genome-and-triticum-dicoccoides-aabb-genome-reveal-differential-antioxidative-response-under-water-stress
#13
Yadhu Suneja, Anil Kumar Gupta, Navtej Singh Bains
Antioxidant enzymes are known to play a significant role in scavenging reactive oxygen species and maintaining cellular homeostasis. Activity of four antioxidant enzymes viz., superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX) and glutathione reductase (GR) was examined in the flag leaves of nine Aegilops tauschii and three Triticum dicoccoides accessions along with two bread wheat cultivars under irrigated and rain-fed conditions. These accessions were shortlisted from a larger set on the basis of field performance for a set of morpho-physiological traits...
January 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/28244393/who-director-general-shortlist-chosen
#14
Talha Burki
No abstract text is available yet for this article.
March 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28242877/epilepsy-associated-grin2a-mutations-reduce-nmda-receptor-trafficking-and-agonist-potency-molecular-profiling-and-functional-rescue
#15
L Addis, J K Virdee, L R Vidler, D A Collier, D K Pal, D Ursu
Mutations in the N-methyl-D-aspartate receptor (NMDAR) gene GRIN2A cause epilepsy-aphasia syndrome (EAS), a spectrum of epileptic, cognitive and language disorders. Using bioinformatic and patient data we shortlisted 10 diverse missense mutations for characterisation. We used high-throughput calcium-flux assays and patch clamp recordings of transiently transfected HEK-293 cells for electrophysiological characterization, and Western blotting and confocal imaging to assay expression and surface trafficking. Mutations P79R, C231Y, G483R and M705V caused a significant reduction in glutamate and glycine agonist potency, whilst D731N was non-responsive...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28228127/a-review-of-enhanced-paramedic-roles-during-and-after-hospital-handover-of-stroke-myocardial-infarction-and-trauma-patients
#16
Darren Flynn, Richard Francis, Shannon Robalino, Joanne Lally, Helen Snooks, Helen Rodgers, Graham McClelland, Gary A Ford, Christopher Price
BACKGROUND: Ambulance paramedics play a critical role expediting patient access to emergency treatments. Standardised handover communication frameworks have led to improvements in accuracy and speed of information transfer but their impact upon time-critical scenarios is unclear. Patient outcomes might be improved by paramedics staying for a limited time after handover to assist with shared patient care. We aimed to categorize and synthesise data from studies describing development/extension of the ambulance-based paramedic role during and after handover for time-critical conditions (trauma, stroke and myocardial infarction)...
February 23, 2017: BMC Emergency Medicine
https://www.readbyqxmd.com/read/28224855/all-the-finalists-revealed-for-rcni-nurse-awards
#17
Stephanie Jones-Berry
The shortlist of finalists for this year's RCNi Nurse Awards 2017 has been revealed. More than 600 entries were received across 14 categories.
February 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28209564/shortlisted-teams-announced-for-the-bmj-awards-2017
#18
Zosia Kmietowicz
No abstract text is available yet for this article.
February 16, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28188016/concurrent-chemoradiotherapy-vs-radiotherapy-alone-in-locally-advanced-cervix-cancer-a-systematic-review-and-meta-analysis
#19
REVIEW
Niloy Ranjan Datta, Emanuel Stutz, Michael Liu, Susanne Rogers, Dirk Klingbiel, Alexander Siebenhüner, Shalini Singh, Stephan Bodis
The efficacy of concurrent chemoradiotherapy (CTRT) in locally advanced cervix cancer (LACC, stages IIB-IVA) is contentious. This is due to the variable extent of therapeutic benefit reported in different randomized clinical trials and meta-analyses that usually include all stages of cervix cancer. A systematic review and meta-analysis was therefore conducted to evaluate the efficacy of concurrent CTRT over radiotherapy (RT) alone, predominantly in LACC for the key endpoints; complete response (CR), long-term loco-regional control (LRC), overall survival (OS), grade III/IV acute and late toxicities...
February 7, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28167232/integrative-network-analysis-reveals-time-dependent-molecular-events-underlying-left-ventricular-remodeling-in-post-myocardial-infarction-patients
#20
Florence Pinet, Marie Cuvelliez, Thomas Kelder, Philippe Amouyel, Marijana Radonjic, Christophe Bauters
To elucidate the time-resolved molecular events underlying the LV remodeling (LVR) process, we developed a large-scale network model that integrates the 24 molecular variables (plasma proteins and non-coding RNAs) collected in the REVE-2 study at four time points (baseline, 1month, 3months and 1year) after MI. The REVE-2 network model was built by extending the set of REVE-2 variables with their mechanistic context based on known molecular interactions (1310 nodes and 8639 edges). Changes in the molecular variables between the group of patients with high LVR (>20%) and low LVR (<20%) were used to identify active network modules within the clusters associated with progression of LVR, enabling assessment of time-resolved molecular changes...
February 3, 2017: Biochimica et Biophysica Acta
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