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https://www.readbyqxmd.com/read/28637770/analgesia-and-opioids-a-pharmacogenetics-shortlist-for-implementation-in-clinical-practice
#1
REVIEW
Maja Matic, Saskia N de Wildt, Dick Tibboel, Ron H N van Schaik
BACKGROUND: The use of opioids to alleviate pain is complicated by the risk of severe adverse events and the large variability in dose requirements. Pharmacogenetics (PGx) could possibly be used to tailor pain medication based on an individual's genetic background. Many potential genetic markers have been described, and the importance of genetic predisposition in opioid efficacy and toxicity has been demonstrated in knockout mouse models and human twin studies. Such predictors are especially of value for neonates and young children, in whom the assessment of efficacy or side effects is complicated by the inability of the patient to communicate this properly...
June 21, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28607805/simplified-microsatellite-instability-detection-protocol-provides-equivalent-sensitivity-to-robust-detection-strategies-in-lynch-syndrome-patients
#2
Hadi Babaei, Mehrdad Zeinalian, Mohammad Hassan Emami, Mortaza Hashemzadeh, Najmeh Farahani, Rasoul Salehi
OBJECTIVE: : Germline mutations in mismatch repair (MMR) genes cause Lynch syndrome (LS). LS is an inherited disease, and an important consequence of MMR deficiency is microsatellite instability (MSI) phenotype. MSI phenotype influences the efficacy of 5 fluorouracil (5-FU) chemotherapy. Reproducible, cost effective, and easy to perform laboratory tests are required to include MSI detection in routine laboratory practice. Evaluation of CAT25 as monomorphic short tandem repeat sequence enables CAT25 to be an efficient screening tool among hereditary nonpolyposis colorectal cancer (HNPCC) patients compared with other methods used currently...
May 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28585374/svmdlf-a-novel-r-based-web-application-for-prediction-of-dipeptidyl-peptidase-4-inhibitors
#3
Sharat Chandra, Jyotsana Pandey, Akhilesh K Tamrakar, Mohammad Imran Siddiqi
Dipeptidyl peptidase 4 (DPP4) is a well-known target for the antidiabetic drugs. However, currently available DPP4 inhibitor screening assays are costly and labor-intensive. It is important to create a robust in-silico method to predict the activity of DPP4 inhibitor for the new lead finding. Here, we introduce a R based web application SVMDLF (SVM based DPP4 Lead Finder) to predict the inhibitor of DPP4; based on support vector machine (SVM) model, predictions of which are confirmed by in-vitro biological evaluation...
June 6, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28558816/intraoperative-electromyographic-monitoring-to-optimize-safe-lumbar-pedicle-screw-placement-a-retrospective-analysis
#4
Arun-Kumar Kaliya-Perumal, Jiun-Ran Charng, Chi-Chien Niu, Tsung-Ting Tsai, Po-Liang Lai, Lih-Huei Chen, Wen-Jer Chen
BACKGROUND: The foremost concern of a surgeon during pedicle screw fixation is safety. Assistive modalities, especially intraoperative electromyographic monitoring (EMG) can function as an essential tool to recognize screw malposition that compromise neural integrity, so that the screws can be repositioned immediately rather than later. We intend to study the efficacy of intraoperative EMG monitoring to detect potential pedicle breach and evaluate whether reoperation rates were significantly reduced...
May 30, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28554931/developing-a-core-outcome-set-for-infant-colic-for-primary-secondary-and-tertiary-care-settings-a-prospective-study
#5
Nina F Steutel, Marc A Benninga, Miranda W Langendam, Judith J Korterink, Flavia Indrio, Hania Szajewska, Merit M Tabbers
OBJECTIVE: Infant colic (IC) is defined as recurrent and prolonged crying without an obvious cause or evidence of failure to thrive or illness. It is a common problem with a prevalence of 5%-25%. The unknown aetiology results in a wide variety in interventions and use of heterogeneous outcome measures across therapeutic trials. Our aim was to develop a core outcome set (COS) for IC to facilitate and improve evidence synthesis. DESIGN AND SETTING: Prospective study design; primary, secondary and tertiary care...
May 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28554921/selection-by-a-panel-of-clinicians-and-family-representatives-of-important-early-morbidities-associated-with-paediatric-cardiac-surgery-suitable-for-routine-monitoring-using-the-nominal-group-technique-and-a-robust-voting-process
#6
Christina Pagel, Katherine L Brown, Isobel McLeod, Helen Jepps, Jo Wray, Linda Chigaru, Andrew McLean, Tom Treasure, Victor Tsang, Martin Utley
OBJECTIVE: With survival following paediatric cardiac surgery improving, the attention of quality assurance and improvement initiatives is shifting to long-term outcomes and early surgical morbidities. We wanted to involve family representatives and a range of clinicians in selecting the morbidities to be measured in a major UK study. SETTING: Paediatric cardiac surgery services in the UK. PARTICIPANTS: We convened a panel comprising family representatives, paediatricians from referring centres, and surgeons and other clinicians from surgical centres...
May 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28487705/genome-wide-association-mapping-reveals-multiple-qtls-governing-tolerance-response-for-seedling-stage-chilling-stress-in-indica-rice
#7
Elssa Pandit, Swaleha Tasleem, Saumya R Barik, Durga P Mohanty, Deepak K Nayak, Shakti P Mohanty, Sujata Das, Sharat K Pradhan
Rice crop is sensitive to cold stress at seedling stage. A panel of population representing 304 shortlisted germplasm lines was studied for seedling stage chilling tolerance in indica rice. Six phenotypic classes were exposed to six low temperature stress regimes under control phenotyping facility to investigate response pattern. A panel of 66 genotypes representing all phenotypic classes was used for ensuring genetic diversity, population structure and association mapping for the trait using 58 simple sequence repeat (SSR) and 2 direct trait linked markers...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28477017/characterization-of-potential-driver-mutations-involved-in-human-breast-cancer-by-computational-approaches
#8
REVIEW
Barani Kumar Rajendran, Chu-Xia Deng
Breast cancer is the second most frequently occurring form of cancer and is also the second most lethal cancer in women worldwide. A genetic mutation is one of the key factors that alter multiple cellular regulatory pathways and drive breast cancer initiation and progression yet nature of these cancer drivers remains elusive. In this article, we have reviewed various computational perspectives and algorithms for exploring breast cancer driver mutation genes. Using both frequency based and mutational exclusivity based approaches, we identified 195 driver genes and shortlisted 63 of them as candidate drivers for breast cancer using various computational approaches...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28473483/antibiotic-awareness-poster-makes-awards-shortlist
#9
(no author information available yet)
No abstract text is available yet for this article.
May 6, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28470390/biallelic-mutations-in-cyp24a1-or-slc34a1-as-a-cause-of-infantile-idiopathic-hypercalcemia-iih-with-vitamin-d-hypersensitivity-molecular-study-of-11-historical-iih-cases
#10
Ewa Pronicka, Elżbieta Ciara, Paulina Halat, Agnieszka Janiec, Marek Wójcik, Elżbieta Rowińska, Dariusz Rokicki, Paweł Płudowski, Ewa Wojciechowska, Aldona Wierzbicka, Janusz B Książyk, Agnieszka Jacoszek, Martin Konrad, Karl P Schlingmann, Mieczysław Litwin
Idiopathic infantile hypercalcemia (IIH) is a mineral metabolism disorder characterized by severe hypercalcemia, failure to thrive, vomiting, dehydration, and nephrocalcinosis. The periodical increase in incidence of IIH, which occurred in the twentieth century in the United Kingdom, Poland, and West Germany, turned out to be a side effect of rickets over-prophylaxis. It was recently discovered that the condition is linked to two genes, CYP24A1 and SLC34A1. The aim of the study was to search for pathogenic variants of the genes in adult persons who were shortlisted in infancy as IIH caused by "hypersensitivity to vit...
May 3, 2017: Journal of Applied Genetics
https://www.readbyqxmd.com/read/28365592/cell-scientist-to-watch-victoria-sanz-moreno
#11
(no author information available yet)
Vicky Sanz-Moreno received her first degree in chemistry and later a master's degree in biochemistry from the University of Oviedo in Spain, followed by a PhD in chemical sciences in the laboratory of Piero Crespo at the University of Cantabria, awarded in 2002. After a short postdoc in the same lab funded by a Lady Tata Memorial Trust Fellowship, she moved to the Institute of Cancer Research in London as a CRUK and Marie Curie Intra-European Fellow to work with Chris Marshall. In 2008, she received the Applied Biosystems and EACR 40th Anniversary Research Award...
April 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28351255/five-worthy-finalists-for-our-patient-s-choice-award
#12
(no author information available yet)
The RCNi Nurse Awards are not only the most prestigious accolades in nursing, they are also the only awards that give patients the opportunity to choose their own nurse of the year. This week we reveal the shortlist for the 2017 RCNi Patient's Choice award, and choosing between the final five will be as challenging as ever.
March 29, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28351241/who-will-be-this-year-s-patient-s-choice
#13
(no author information available yet)
Our five Patient's Choice finalists have been shortlisted from scores of nominations. The award, sponsored by Yakult, enables members of the public to thank a nurse or midwife who has made a real difference to their care or that of a loved one. Smooth Radio and Good Morning Britain presenter Kate Garraway will announce the winner at the RCNi Nurse Awards ceremony in London on 5 May. RCNi editorial director Graham Scott says: 'Here are five inspirational nurses and five examples of outstanding care that all deserve an award...
March 29, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28340318/is-there-a-relationship-between-postural-alignment-and-mobility-for-adults-after-acquired-brain-injury-a-systematic-review
#14
Simon J Mills, Michelle N McDonnell, Dominic Thewlis, Shylie Mackintosh
PRIMARY OBJECTIVE: To examine the relationship between postural alignment and mobility skills for adults after acquired brain injury (ABI). METHODS: Systematic review of the literature. Seven electronic databases, grey literature and reference lists of the shortlisted publications were searched. Studies were included if participants were adults with ABI, both postural alignment and mobility were measured and analysis included a relationship between alignment and mobility...
March 24, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28330176/molecular-dissection-of-pathway-components-unravel-atisine-biosynthesis-in-a-non-toxic-aconitum-species-a-heterophyllum-wall
#15
Varun Kumar, Nikhil Malhotra, Tarun Pal, Rajinder Singh Chauhan
Aconitum heterophyllum is an important component for various herbal drug formulations due to the occurrence of non-toxic aconites including marker compound, atisine. Despite huge pharmacological potential, the reprogramming of aconites production is limited due to lack of understanding on their biosynthesis. To address this problem, we have proposed here the complete atisine biosynthetic pathway for the first time connecting glycolysis, MVA/MEP, serine biosynthesis and diterpene biosynthetic pathways. The transcript profiling revealed phosphorylated pathway as a major contributor towards serine production in addition to repertoire of genes in glycolysis (G6PI, PFK, ALD and ENO), serine biosynthesis (PGDH and PSAT) and diterpene biosynthesis (KO and KH) sharing a similar pattern of expression (2-4-folds) in roots compared to shoots vis-à-vis atisine content (0-0...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28327008/shortlist-revealed-for-patient-s-choice-category
#16
(no author information available yet)
Voting is now open for the Patient's Choice category of the RCNi Nurse Awards 2017.
March 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28273037/status-report-identifying-equity-focussed-interventions-to-promote-healthy-weights
#17
C James Frankish, Brenda Kwan, Diane E Gray, Andrea Simpson, Nina Jetha
INTRODUCTION: We developed screening criteria to identify population health interventions with an equity focus for inclusion on the Public Health Agency of Canada's Canadian Best Practices Portal. We applied them to the area of "healthy weights," specifically, obesity prevention. METHODS: We conducted a review of the literature and obtained input from expert external reviewers on changes to midstream environments. Interventions had to identify outcomes for groups with an underlying social disadvantage...
March 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/28262059/child-health-category-shortlist-revealed
#18
(no author information available yet)
Finalists for the child health award at the RCNi Nurse Awards 2017 have been revealed.
March 6, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/28250587/bread-wheat-progenitors-aegilops-tauschii-dd-genome-and-triticum-dicoccoides-aabb-genome-reveal-differential-antioxidative-response-under-water-stress
#19
Yadhu Suneja, Anil Kumar Gupta, Navtej Singh Bains
Antioxidant enzymes are known to play a significant role in scavenging reactive oxygen species and maintaining cellular homeostasis. Activity of four antioxidant enzymes viz., superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX) and glutathione reductase (GR) was examined in the flag leaves of nine Aegilops tauschii and three Triticum dicoccoides accessions along with two bread wheat cultivars under irrigated and rain-fed conditions. These accessions were shortlisted from a larger set on the basis of field performance for a set of morpho-physiological traits...
January 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/28244393/who-director-general-shortlist-chosen
#20
Talha Burki
No abstract text is available yet for this article.
March 2017: Lancet Infectious Diseases
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