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https://www.readbyqxmd.com/read/29649022/effectiveness-of-chinese-martial-arts-and-philosophy-to-reduce-reactive-and-proactive-aggression-in-schoolchildren
#1
Annis Lai Chu Fung, Toney Ka Hung Lee
OBJECTIVE: This study examined the effectiveness of Chinese martial arts in reducing reactive and proactive aggressive behavior among schoolchildren with a cluster-randomized trial. METHODS: A screening questionnaire was completed by 3511 schoolchildren of Grades 2 to 5 from 13 sites in Hong Kong. We shortlisted 298 children who scored z ≥ 1 on the total score of the Reactive-Proactive Aggression Questionnaire in their respective sites to participate in the experiment...
April 10, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29644941/role-of-micrornas-in-treatment-response-in-prostate-cancer
#2
Anshuli Razdan, Paul de Souza, Tara Laurie Roberts
Prostate cancer (PCa) is the most common non-skin cancer in men worldwide, resulting in significant mortality and morbidity. Depending on the grade and stage of the cancer, patients may be given radiation therapy, hormonal therapy, or chemotherapy. However, more than half these patients develop resistance to treatment, leading to disease progression and metastases, often with lethal consequences. MicroRNAs (miRNAs) are short, non-coding RNAs, which regulate numerous physiological as well as pathological processes, including cancer...
March 15, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29592867/periprostatic-fat-tissue-transciptome-reveals-a-signature-diagnostic-for-high-risk-prostate-cancer
#3
Stefano Mangiola, Ryan Stuchbery, Geoff Macintyre, Michael J Clarkson, Justin S Peters, Anthony J Costello, Christopher M Hovens, Niall M Corcoran
Evidence suggests that altered adipose tissue homeostasis may be an important contributor to the development and/or progression of prostate cancer. In this study we investigated the adipose transcriptional profiles of low- and high-risk disease to determine both prognostic potential and possible biological drivers of aggressive disease. RNA was extracted from periprostatic adipose tissue from patients categorised as having prostate cancer with either a high- or low-risk of progression based on tumour characteristics at prostatectomy and profiled by RNA sequencing...
March 28, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29587180/prioritization-of-potential-drug-targets-against-p-aeruginosa-by-core-proteomic-analysis-using-computational-subtractive-genomics-and-protein-protein-interaction-network
#4
Reaz Uddin, Faiza Jamil
Pseudomonas aeruginosa is an opportunistic gram-negative bacterium that has the capability to acquire resistance under hostile conditions and become a threat worldwide. It is involved in nosocomial infections. In the current study, potential novel drug targets against P. aeruginosa have been identified using core proteomic analysis and Protein-Protein Interactions (PPIs) studies. The non-redundant reference proteome of 68 strains having complete genome and latest assembly version of P. aeruginosa were downloaded from ftp NCBI RefSeq server in October 2016...
March 8, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29529275/combinatorial-regulation-of-stilbene-synthase-genes-by-wrky-and-myb-transcription-factors-in-grapevine-vitis-vinifera-l
#5
Alessandro Vannozzi, Darren Chern Jan Wong, Janine Höll, Ibrahim Hmmam, José Tomás Matus, Jochen Bogs, Tobias Ziegler, Ian Dry, Gianni Barcaccia, Margherita Lucchin
Stilbene synthase (STS) is the key enzyme leading to the biosynthesis of resveratrol. Recently we reported two R2R3-MYB transcription factors (TFs) that regulate the stilbene biosynthetic pathway in grapevine: VviMYB14 and VviMYB15. These genes strongly co-express with STSs under a range of stress and developmental conditions, in agreement with the specific activation of STS promoters by these TFs. Genome-wide gene co-expression analysis using two separate transcriptome compendia based on microarray and RNA-Seq data revealed that WRKY TFs were the top TF family correlated with STS genes...
February 26, 2018: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29528460/systematic-review-chronic-obstructive-pulmonary-disease-and-work-related-outcomes
#6
K K Rai, P Adab, J G Ayres, R E Jordan
Background: Several studies have assessed the impact of chronic obstructive pulmonary disease (COPD) on work ability and work productivity; however, this relationship is poorly understood. Aims: To undertake a systematic review to assess the effects of COPD on employment, absenteeism and presenteeism. Methods: A comprehensive search using CINAHL, Embase, MEDLINE and the Cochrane Library was conducted to include epidemiological studies from 1937 to August 2017...
March 8, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29518093/selection-and-characterization-of-probiotic-lactic-acid-bacteria-and-its-impact-on-growth-nutrient-digestibility-health-and-antioxidant-status-in-weaned-piglets
#7
Runjun Dowarah, Ashok Kumar Verma, Neeta Agarwal, Putan Singh, Bhoj Raj Singh
The present study was aimed to develop an effective probiotic lactic acid bacteria (LAB) from piglet feces and in vitro characterization of probiotic properties. To confirm host-species specificity of probiotics, the efficacy of isolated LAB on growth, nutrient utilization, health and antioxidant status was observed in early weaned piglets. A total of 30 LAB were isolated from feces of five healthy piglets (28d old). All isolates were Gram positive, cocco-bacilli and catalase negative. Out of thirty LAB isolates, twenty were shortlisted on the basis of their tolerance to pH (3...
2018: PloS One
https://www.readbyqxmd.com/read/29516011/meta-analysis-of-mirnas-and-their-involvement-as-biomarkers-in-oral-cancers
#8
Andleeb Zahra, Itrat Rubab, Sumaira Malik, Amina Khan, Muhammad Jawad Khan, M Qaiser Fatmi
Oral Squamous Cell Carcinoma (OSCC) is one of the most common cancers worldwide. Recent studies have highlighted the role of miRNA in disease pathology, indicating its potential use as an early diagnostic marker. Dysregulated expression of miRNAs is known to affect cell growth, and these may function as tumor suppressors or oncogenes in various cancers. The main objective of this study was to characterize the extracellular miRNAs involved in oral cancer (OC) that can potentially be used as biomarkers of OC...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29511908/qtl-mapping-and-candidate-gene-analysis-of-peduncle-vascular-bundle-related-traits-in-rice-by-genome-wide-association-study
#9
Laiyuan Zhai, Tianqing Zheng, Xinyu Wang, Yun Wang, Kai Chen, Shu Wang, Yun Wang, Jianlong Xu, Zhikang Li
BACKGROUND: The vascular bundle especially in the peduncle is one of crucial limiting factors of rice yield, and it determines how plants efficiently transport photosynthetic products, mineral nutrients and water from leaf and root to panicle. However, the genetic base of rice vascular bundle related traits in the peduncle still remains unknown. RESULTS: The 423 panel showed substantial natural variations of peduncle vascular bundle. In total, 48 quantitative trait loci/locus (QTL) affecting the eight traits were identified throughout the genome by applying a significance threshold of P < 1...
March 6, 2018: Rice
https://www.readbyqxmd.com/read/29490930/shortlisted-teams-are-announced-for-10th-bmj-awards
#10
Zosia Kmietowicz
No abstract text is available yet for this article.
February 28, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29490702/identifying-trial-recruitment-uncertainties-using-a-james-lind-alliance-priority-setting-partnership-the-priority-prioritising-recruitment-in-randomised-trials-study
#11
Patricia Healy, Sandra Galvin, Paula R Williamson, Shaun Treweek, Caroline Whiting, Beccy Maeso, Christopher Bray, Peter Brocklehurst, Mary Clarke Moloney, Abdel Douiri, Carrol Gamble, Heidi R Gardner, Derick Mitchell, Derek Stewart, Joan Jordan, Martin O'Donnell, Mike Clarke, Sue H Pavitt, Eleanor Woodford Guegan, Amanda Blatch-Jones, Valerie Smith, Hannah Reay, Declan Devane
BACKGROUND: Despite the problem of inadequate recruitment to randomised trials, there is little evidence to guide researchers on decisions about how people are effectively recruited to take part in trials. The PRioRiTy study aimed to identify and prioritise important unanswered trial recruitment questions for research. The PRioRiTy study - Priority Setting Partnership (PSP) included members of the public approached to take part in a randomised trial or who have represented participants on randomised trial steering committees, health professionals and research staff with experience of recruiting to randomised trials, people who have designed, conducted, analysed or reported on randomised trials and people with experience of randomised trials methodology...
March 1, 2018: Trials
https://www.readbyqxmd.com/read/29486730/centralising-specialist-cancer-surgery-services-in-england-survey-of-factors-that-matter-to-patients-and-carers-and-health-professionals
#12
Mariya Melnychuk, Cecilia Vindrola-Padros, Michael Aitchison, Caroline S Clarke, Naomi J Fulop, Claire Levermore, Satish B Maddineni, Caroline M Moore, Muntzer M Mughal, Catherine Perry, Kathy Pritchard-Jones, Angus I G Ramsay, David Shackley, Jonathan Vickers, Stephen Morris
BACKGROUND: The centralisation of specialist cancer surgical services across London Cancer and Greater Manchester Cancer, England, may significantly change how patients experience care. These centres are changing specialist surgical pathways for several cancers including prostate, bladder, kidney, and oesophago-gastric cancers, increasing the specialisation of centres and providing surgery in fewer hospitals. While there are potential benefits related to centralising services, changes of this kind are often controversial...
February 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29485717/setting-the-top-10-research-priorities-to-improve-the-health-of-people-with-type-2-diabetes-a-diabetes-uk-james-lind-alliance-priority-setting-partnership
#13
S Finer, P Robb, K Cowan, A Daly, K Shah, A Farmer
AIMS: To describe processes and outcomes of a priority setting partnership to identify the 'top 10 research priorities' in Type 2 diabetes, involving people living with the condition, their carers, and healthcare professionals. METHODS: We followed the four-step James Lind Alliance Priority Setting Partnership process which involved: gathering uncertainties using a questionnaire survey distributed to 70 000 people living with Type 2 diabetes and their carers, and healthcare professionals; organizing the uncertainties; interim priority setting by resampling of participants with a second survey; and final priority setting in an independent group of participants, using the nominal group technique...
February 27, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29468945/a-novel-identification-approach-for-discovery-of-5-hydroxytriptamine-2a-antagonists-combination-of-2d-3d-similarity-screening-molecular-docking-and-molecular-dynamics
#14
Rakesh Kumar, Dhananjay Jade, Dinesh Gupta
5-HydroxyTriptamine 2A antagonists are potential targets for treatment of various cerebrovascular and cardiovascular disorders. In this study we have developed and performed a unique screening pipeline for filtering ZINC database compounds on the basis of similarities to known antagonists to determine novel small molecule antagonists of 5-HydroxyTriptamine 2A. The screening pipeline is based on 2D similarity, 3D dissimilarity and a combination of 2D/3D similarity. The shortlisted compounds were docked to a 5-HydroxyTriptamine 2A homology based model, and complexes with low binding energies (287 complexes) were selected for molecular dynamics (MD) simulations in a lipid bilayer...
February 22, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29456689/inhibition-of-the-ras-raf-extracellular-signal-regulated-kinase-1-2-signaling-pathway-by-compounds-of-natural-origin-for-possible-treatment-of-spinal-cord-injury-an-in-silico-approach
#15
Shilei Yan, Li Zhang, Shuai Wang, Tianhao Wu, Zhixin Gong
Spinal cord injury (SCI) is a severe disease associated with permanent neurological deficit. Recent studies in the treatment of SCI have demonstrated that the Ras/Raf/extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway serves an important role in the disease etiology, and that upregulation of this signaling pathway is associated with the development of SCI. In the present study, inhibition of Ras protein was employed in order to downregulate the Ras/Raf/ERK1/2 signaling pathway using compounds of natural origin from the Interbioscreen natural compound database...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29444767/patient-reported-measures-for-person-centered-coordinated-care-a-comparative-domain-map-and-web-based-compendium-for-supporting-policy-development-and-implementation
#16
Helen Lloyd, Hannah Wheat, Jane Horrell, Thavapriya Sugavanam, Benjamin Fosh, Jose M Valderas, James Close
BACKGROUND: Patient-reported measure (PRM) questionnaires were originally used in research to measure outcomes of intervention studies. They have now evolved into a diverse family of tools measuring a range of constructs including quality of life and experiences of care. Current health and social care policy increasingly advocates their use for embedding the patient voice into service redesign through new models of care such as person-centered coordinated care (P3C). If chosen carefully and used efficiently, these tools can help improve care delivery through a variety of novel ways, including system-level feedback for health care management and commissioning...
February 14, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29444691/affinity-proteomic-profiling-of-plasma-for-proteins-associated-to-area-based-mammographic-breast-density
#17
Sanna Byström, Martin Eklund, Mun-Gwan Hong, Claudia Fredolini, Mikael Eriksson, Kamila Czene, Per Hall, Jochen M Schwenk, Marike Gabrielson
BACKGROUND: Mammographic breast density is one of the strongest risk factors for breast cancer, but molecular understanding of how breast density relates to cancer risk is less complete. Studies of proteins in blood plasma, possibly associated with mammographic density, are well-suited as these allow large-scale analyses and might shed light on the association between breast cancer and breast density. METHODS: Plasma samples from 1329 women in the Swedish KARMA project, without prior history of breast cancer, were profiled with antibody suspension bead array (SBA) assays...
February 14, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29436980/virtual-screening-of-natural-inhibitors-targeting-ornithine-decarboxylase-with-pharmacophore-scaffolding-of-dfmo-and-validation-by-molecular-dynamics-simulation-studies
#18
Sivashanmugam Muthukumaran, K N Sulochana, V Umashankar
Ornithine Decarboxylase (ODC) is an enzyme that initiates polyamine synthesis in human. Polyamines play key roles in cell-cell adhesion, cell motility and Cell cycle regulation. Higher synthesis of polyamines also occurs in rapidly proliferating cancer cells are mediated by ODC. As per earlier studies, Di-Flouro Methyl Orninthine (DFMO) is a proven efficient inhibitor ODC targeting the catalytic activity, however, its usage is limited due to side effects. Targeting ODC is considered as a potential therapeutic modality in the treatment of cancer...
February 13, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29427454/proteomics-in-biomanufacturing-control-protein-dynamics-of-cho-k1-cells-and-conditioned-media-during-apoptosis-and-necrosis
#19
Simone Albrecht, Christian Kaisermayer, Clair Gallagher, Amy Farrell, Anna Lindeberg, Jonathan Bones
Cell viability has a critical impact on product quantity and quality during the biomanufacturing of therapeutic proteins. An advanced understanding of changes in the cellular and conditioned media proteomes upon cell stress and death is therefore needed for improved bioprocess control. Here, a high pH / low pH reversed phase data independent 2D-LC-MSE discovery proteomics platform was applied to study the cellular and conditioned media proteomes of CHO-K1 apoptosis and necrosis models where cell death was induced by staurosporine exposure or aeration shear in a benchtop bioreactor, respectively...
February 10, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29425325/selenzyme-enzyme-selection-tool-for-pathway-design
#20
Pablo Carbonell, Jerry Wong, Neil Swainston, Eriko Takano, Nicholas J Turner, Nigel S Scrutton, Douglas B Kell, Rainer Breitling, Jean-Loup Faulon, Oliver Stegle
Summary: Synthetic biology applies the principles of engineering to biology in order to create biological functionalities not seen before in nature. One of the most exciting applications of synthetic biology is the design of new organisms with the ability to produce valuable chemicals including pharmaceuticals and biomaterials in a greener; sustainable fashion. Selecting the right enzymes to catalyze each reaction step in order to produce a desired target compound is, however, not trivial...
February 7, 2018: Bioinformatics
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