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https://www.readbyqxmd.com/read/28228127/a-review-of-enhanced-paramedic-roles-during-and-after-hospital-handover-of-stroke-myocardial-infarction-and-trauma-patients
#1
Darren Flynn, Richard Francis, Shannon Robalino, Joanne Lally, Helen Snooks, Helen Rodgers, Graham McClelland, Gary A Ford, Christopher Price
BACKGROUND: Ambulance paramedics play a critical role expediting patient access to emergency treatments. Standardised handover communication frameworks have led to improvements in accuracy and speed of information transfer but their impact upon time-critical scenarios is unclear. Patient outcomes might be improved by paramedics staying for a limited time after handover to assist with shared patient care. We aimed to categorize and synthesise data from studies describing development/extension of the ambulance-based paramedic role during and after handover for time-critical conditions (trauma, stroke and myocardial infarction)...
February 23, 2017: BMC Emergency Medicine
https://www.readbyqxmd.com/read/28224855/all-the-finalists-revealed-for-rcni-nurse-awards
#2
Stephanie Jones-Berry
The shortlist of finalists for this year's RCNi Nurse Awards 2017 has been revealed. More than 600 entries were received across 14 categories.
February 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28209564/shortlisted-teams-announced-for-the-bmj-awards-2017
#3
Zosia Kmietowicz
No abstract text is available yet for this article.
February 16, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28188016/concurrent-chemoradiotherapy-vs-radiotherapy-alone-in-locally-advanced-cervix-cancer-a-systematic-review-and-meta-analysis
#4
REVIEW
Niloy Ranjan Datta, Emanuel Stutz, Michael Liu, Susanne Rogers, Dirk Klingbiel, Alexander Siebenhüner, Shalini Singh, Stephan Bodis
The efficacy of concurrent chemoradiotherapy (CTRT) in locally advanced cervix cancer (LACC, stages IIB-IVA) is contentious. This is due to the variable extent of therapeutic benefit reported in different randomized clinical trials and meta-analyses that usually include all stages of cervix cancer. A systematic review and meta-analysis was therefore conducted to evaluate the efficacy of concurrent CTRT over radiotherapy (RT) alone, predominantly in LACC for the key endpoints; complete response (CR), long-term loco-regional control (LRC), overall survival (OS), grade III/IV acute and late toxicities...
February 7, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28167232/integrative-network-analysis-reveals-time-dependent-molecular-events-underlying-left-ventricular-remodeling-in-post-myocardial-infarction-patients
#5
Florence Pinet, Marie Cuvelliez, Thomas Kelder, Philippe Amouyel, Marijana Radonjic, Christophe Bauters
To elucidate the time-resolved molecular events underlying the LV remodeling (LVR) process, we developed a large-scale network model that integrates the 24 molecular variables (plasma proteins and non-coding RNAs) collected in the REVE-2 study at four time points (baseline, 1month, 3months and 1year) after MI. The REVE-2 network model was built by extending the set of REVE-2 variables with their mechanistic context based on known molecular interactions (1310 nodes and 8639 edges). Changes in the molecular variables between the group of patients with high LVR (>20%) and low LVR (<20%) were used to identify active network modules within the clusters associated with progression of LVR, enabling assessment of time-resolved molecular changes...
February 3, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28153039/metabolomics-variable-selection-and-classification-in-the-presence-of-observations-below-the-detection-limit-using-an-extension-of-erp
#6
Mari van Reenen, Johan A Westerhuis, Carolus J Reinecke, J Hendrik Venter
BACKGROUND: ERp is a variable selection and classification method for metabolomics data. ERp uses minimized classification error rates, based on data from a control and experimental group, to test the null hypothesis of no difference between the distributions of variables over the two groups. If the associated p-values are significant they indicate discriminatory variables (i.e. informative metabolites). The p-values are calculated assuming a common continuous strictly increasing cumulative distribution under the null hypothesis...
February 2, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28130245/three-shortlisted-candidates-bid-to-lead-who
#7
Anne Gulland
No abstract text is available yet for this article.
January 27, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28065665/unbiased-identification-of-blood-based-biomarkers-for-pulmonary-tuberculosis-by-modeling-and-mining-molecular-interaction-networks
#8
Awanti Sambarey, Abhinandan Devaprasad, Abhilash Mohan, Asma Ahmed, Soumya Nayak, Soumya Swaminathan, George D'Souza, Anto Jesuraj, Chirag Dhar, Subash Babu, Annapurna Vyakarnam, Nagasuma Chandra
Efficient diagnosis of tuberculosis (TB) is met with multiple challenges, calling for a shift of focus from pathogen-centric diagnostics towards identification of host-based multi-marker signatures. Transcriptomics offer a list of differentially expressed genes, but cannot by itself identify the most influential contributors to the disease phenotype. Here, we describe a computational pipeline that adopts an unbiased approach to identify a biomarker signature. Data from RNA sequencing from whole blood samples of TB patients were integrated with a curated genome-wide molecular interaction network, from which we obtain a comprehensive perspective of variations that occur in the host due to TB...
February 2017: EBioMedicine
https://www.readbyqxmd.com/read/28059505/predicting-plant-invasions-following-china-s-water-diversion-project
#9
Dasheng Liu, Rui Wang, Doria R Gordon, Xihua Sun, Lu Chen, Yanwen Wang
China's South to North Water Diversion (SNWD) project connects portions of the Yangtze River in the south to the Yellow River system in the north, overcoming biogeographic barriers to water movement. The diversion will supply potable water to over 110 million people and provide multiple other socioeconomic benefits. However, an inadvertent negative impact of this connection includes creation of conduits for species invasions. Alligator weed (Alternanthera philoxeroides), water hyacinth (Eichhornia crassipes), and water lettuce (Pistia stratiotes) are the only aquatic plant species on China's shortlists for special control...
January 24, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28040614/recommendation-for-a-test-battery-for-the-ecotoxicological-evaluation-of-the-environmental-safety-of-construction-products
#10
Stefan Gartiser, Ines Heisterkamp, Ute Schoknecht, Nicole Bandow, N Michael Burkhardt, Monika Ratte, Outi Ilvonen
The European Construction Products Regulation allows Member States to adopt rules for evaluating the environmental impact of their buildings. The aim of the project was to develop recommendations for a test battery for the ecotoxicological assessment of the environmental impact of construction products for outdoor use and contribute to the European harmonization of test methods. From a shortlist of 39 products 20 products were included in the ecotoxicological testing program. Monolithic and plate-like construction products were eluted in the Dynamic Surface Leaching test (DSLT) in accordance with CEN/TS 16637-2, granular products were eluted in a one stage batch test in accordance with DIN EN 12457-1...
December 23, 2016: Chemosphere
https://www.readbyqxmd.com/read/28008612/a-large-sample-test-of-a-semi-automated-clavicle-search-engine-to-assist-skeletal-identification-by-radiograph-comparison
#11
Susan S D'Alonzo, Pierre Guyomarc'h, John E Byrd, Carl N Stephan
In 2014, a morphometric capability to search chest radiograph databases by quantified clavicle shape was published to assist skeletal identification. Here, we extend the validation tests conducted by increasing the search universe 18-fold, from 409 to 7361 individuals to determine whether there is any associated decrease in performance under these more challenging circumstances. The number of trials and analysts were also increased, respectively, from 17 to 30 skeletons, and two to four examiners. Elliptical Fourier analysis was conducted on clavicles from each skeleton by each analyst (shadowgrams trimmed from scratch in every instance) and compared to the search universe...
January 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28005150/early-trends-in-bronchoscopic-lung-volume-reduction-a-systematic-review-and-meta-analysis-of-efficacy-parameters
#12
REVIEW
Abhishek Kumar, Rajany Dy, Kanwaljit Singh, M Jeffery Mador
INTRODUCTION: The goal of our systematic review and meta-analysis is to examine the therapeutic effectiveness of bronchoscopic lung volume reduction (BLVR), and to compare it with medical management and lung volume reduction surgery. METHODS: Variables of interest were absolute change in FEV1, 6MWT, and SGRQ. Meta-analysis was performed for the BLVR modalities with ≥3 trials. Of the 18 shortlisted publications, only valves (four trials; n = 159) and coils (six trials; n = 194) qualified for meta-analysis...
December 22, 2016: Lung
https://www.readbyqxmd.com/read/28000560/ligand-based-pharmacophore-modeling-and-extended-bioactivity-prediction-for-salinosporamide-a-b-and-c-from-marine-actinomycetes-salinispora-tropica
#13
Kesavan Dineshkumar, Aparna Vasudevan, Waheeta Hopper
Actinomycetes are microorganisms producing structurally unique secondary metabolites with pharmaceutically essential bioactivities. Salinispora is an obligate marine actinomycete which produces structurally varied and unique secondary metabolites. There is plenty of scope for the development of drugs out of these novel compounds isolated from Salinispora. Salinosporamides A, B and C are secondary metabolites identified from Salinispora. Anticancer, antibacterial and anti-protozoa activity have been shown in previous studies, which make them interesting subjects for further extended biological activity prediction...
December 15, 2016: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/27992827/development-of-a-snp-based-panel-for-human-identification-for-indian-populations
#14
Anujit Sarkar, Madhusudan R Nandineni
The widely employed short tandem repeat (STR)-based panels for forensic human identification (HID) have limitations while dealing with challenging forensic samples involving DNA degradation, resulting in dropping-out of higher molecular weight alleles/loci. To address this issue, bialleic markers like single nucleotide polymorphisms (SNPs) and insertion-deletions (indels), which can be scored even when the template DNA is heavily degraded (<100bp), have been suggested as alternative markers for HID testing...
December 5, 2016: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/27987574/-new-choosing-wisely-recommendations-of-inappropriate-interventions-the-perspective-of-general-practioners-in-switzerland
#15
Stefan Neuner-Jehle, Oliver Senn, Thomas Rosemann
AIM: As part of the "Choosing wisely" campaign expert-driven recommendations of inappropriate interventions which lead to overdiagnosis and overtreatment are being published. The aim of our work was to describe an innovative method for developing recommendations together with general practitioners (GPs) and to compare the results with the "Choosing wisely" campaign lists as well as with the Swiss "Smarter medicine" shortlist. METHODS: We asked 109 GPs who attended a medical education conference to form groups (of 5 to 7 GPs each) and develop three interventions that are relevant to their work and should be avoided...
December 2016: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/27974530/the-2016-journal-of-experimental-biology-outstanding-paper-prize-shortlist-and-winner
#16
Kathryn Knight
No abstract text is available yet for this article.
December 15, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27958775/distinct-molecular-signature-of-murine-fetal-liver-and-adult-hematopoietic-stem-cells-identify-novel-regulators-of-hematopoietic-stem-cell-function
#17
Javed K Manesia, Monica Franch, Daniel Tabas-Madrid, Ruben Nogales-Cadenas, Thomas Vanwelden, Elisa Van Den Bosch, Zhuofei Xu, Alberto Pascual-Montano, Satish Khurana, Catherine M Verfaillie
During ontogeny, fetal liver (FL) acts as a major site for hematopoietic stem cell (HSC) maturation and expansion, whereas HSCs in the adult bone marrow (ABM) are largely quiescent. HSCs in the FL possess faster repopulation capacity as compared with ABM HSCs. However, the molecular mechanism regulating the greater self-renewal potential of FL HSCs has not yet extensively been assessed. Recently, we published RNA sequencing-based gene expression analysis on FL HSCs from 14.5-day mouse embryo (E14.5) in comparison to the ABM HSCs...
February 13, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/27917941/comparative-phylogenomic-analysis-provides-insights-into-tcp-gene-functions-in-sorghum
#18
Aleena Francis, Namrata Dhaka, Mohit Bakshi, Ki-Hong Jung, Manoj K Sharma, Rita Sharma
Sorghum is a highly efficient C4 crop with potential to mitigate challenges associated with food, feed and fuel. TCP proteins are of particular interest for crop improvement programs due to their well-demonstrated roles in crop domestication and shaping plant architecture thereby, affecting agronomic traits. We identified 20 TCP genes from Sorghum. Except SbTCP8, all are either intronless or contain introns in the untranslated regions. Comparative phylogenetic analysis of Arabidopsis, rice, Brachypodium and Sorghum TCP proteins revealed two distinct classes categorized into ten sub-clades...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27861942/the-ectopic-accessory-parotid-system-with-congenital-cheek-fistula-an-overview-and-current-update
#19
REVIEW
Mainak Dutta
OBJECTIVE: This review attempts to provide a comprehensive, updated overview of the ectopic accessory parotid system (EAPS) from clinical and developmental perspectives and investigates its eligibility to be included in the oculo-auriculo-vertebral spectrum (OAVS). REVIEW METHODS: Results of the keyword-based search in the PubMed/MEDLINE, Google Scholar, LILACS, and Cochrane Library were subjected to the given inclusion and exclusion criteria that corroborated with the definition of EAPS...
November 12, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27830256/clinical-natural-language-processing-in-2015-leveraging-the-variety-of-texts-of-clinical-interest
#20
A Névéol, P Zweigenbaum
OBJECTIVE: To summarize recent research and present a selection of the best papers published in 2015 in the field of clinical Natural Language Processing (NLP). METHOD: A systematic review of the literature was performed by the two section editors of the IMIA Yearbook NLP section by searching bibliographic databases with a focus on NLP efforts applied to clinical texts or aimed at a clinical outcome. Section editors first selected a shortlist of candidate best papers that were then peer-reviewed by independent external reviewers...
November 10, 2016: Yearbook of Medical Informatics
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