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https://www.readbyqxmd.com/read/27861942/the-ectopic-accessory-parotid-system-with-congenital-cheek-fistula-an-overview-and-current-update
#1
REVIEW
Mainak Dutta
OBJECTIVE: This review attempts to provide a comprehensive, updated overview of the ectopic accessory parotid system (EAPS) from clinical and developmental perspectives and investigates its eligibility to be included in the oculo-auriculo-vertebral spectrum (OAVS). REVIEW METHODS: Results of the keyword-based search in the PubMed/MEDLINE, Google Scholar, LILACS, and Cochrane Library were subjected to the given inclusion and exclusion criteria that corroborated with the definition of EAPS...
November 12, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27830256/clinical-natural-language-processing-in-2015-leveraging-the-variety-of-texts-of-clinical-interest
#2
A Névéol, P Zweigenbaum
OBJECTIVE: To summarize recent research and present a selection of the best papers published in 2015 in the field of clinical Natural Language Processing (NLP). METHOD: A systematic review of the literature was performed by the two section editors of the IMIA Yearbook NLP section by searching bibliographic databases with a focus on NLP efforts applied to clinical texts or aimed at a clinical outcome. Section editors first selected a shortlist of candidate best papers that were then peer-reviewed by independent external reviewers...
November 10, 2016: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/27818965/alcohol-related-dementia-and-neurocognitive-impairment-a-review-study
#3
REVIEW
Ankur Sachdeva, Mina Chandra, Mona Choudhary, Prabhoo Dayal, Kuljeet Singh Anand
CONTEXT: Alcohol consumption has escalated rapidly in many countries over the past decade. Evidence suggests a correlation between alcohol use and cognitive decline. We have systematically reviewed the concept and controversies, epidemiology, nosology, neuropathology and neurobiology, neuropsychology and management updates of alcohol-related dementia (ARD) in this paper. EVIDENCE ACQUISITION: We retrieved papers for this review by searching the PubMed database for terms "alcohol and dementia", "alcohol and cognitive impairment", and "alcohol and wernicke-korsakoff" mentioned in the title of the published papers...
September 2016: International Journal of High Risk Behaviors & Addiction
https://www.readbyqxmd.com/read/27815233/app-chronic-disease-checklist-protocol-to-evaluate-mobile-apps-for-chronic-disease-self-management
#4
Kevin Anderson, Oksana Burford, Lynne Emmerton
BACKGROUND: The availability of mobile health apps for self-care continues to increase. While little evidence of their clinical impact has been published, there is general agreement among health authorities and authors that consumers' use of health apps assist in self-management and potentially clinical decision making. A consumer's sustained engagement with a health app is dependent on the usability and functionality of the app. While numerous studies have attempted to evaluate health apps, there is a paucity of published methods that adequately recognize client experiences in the academic evaluation of apps for chronic conditions...
November 4, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27784233/physiotherapy-for-ankylosing-spondylitis-systematic-review-and-a-proposed-rehabilitation-protocol
#5
Deepak Sharan, Joshua Samuel Rajkumar
Ankylosing Spondylitis (AS) is a chronic inflammatory disease of insidious onset, mostly affecting the axial skeleton. It leads to varying degrees of restricted spinal mobility, pain and loss of functional capacity. Rehabilitation, especially Physiotherapy and exercises, are considered integral components of its management. Various rehabilitation modalities are available for the benefit of individuals with AS, but a sequenced protocol has not been reported. A scientific review was performed using the following search engines: MEDLINE (Pubmed), COCHRANE Library and Physiotherapy Evidence Database (PEDro)...
October 25, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27767932/automated-tests-for-diagnosing-and-monitoring-cognitive-impairment-a-diagnostic-accuracy-review
#6
Rabeea'h W Aslam, Vickie Bates, Yenal Dundar, Juliet Hounsome, Marty Richardson, Ashma Krishan, Rumona Dickson, Angela Boland, Eleanor Kotas, Joanne Fisher, Sudip Sikdar, Louise Robinson
BACKGROUND: Cognitive impairment is a growing public health concern, and is one of the most distinctive characteristics of all dementias. The timely recognition of dementia syndromes can be beneficial, as some causes of dementia are treatable and are fully or partially reversible. Several automated cognitive assessment tools for assessing mild cognitive impairment (MCI) and early dementia are now available. Proponents of these tests cite as benefits the tests' repeatability and robustness and the saving of clinicians' time...
October 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27677171/in-search-for-geroprotectors-in-silico-screening-and-in-vitro-validation-of-signalome-level-mimetics-of-young-healthy-state
#7
Alexander Aliper, Aleksey V Belikov, Andrew Garazha, Leslie Jellen, Artem Artemov, Maria Suntsova, Alena Ivanova, Larisa Venkova, Nicolas Borisov, Anton Buzdin, Polina Mamoshina, Evgeny Putin, Andrew G Swick, Alexey Moskalev, Alex Zhavoronkov
Populations in developed nations throughout the world are rapidly aging, and the search for geroprotectors, or anti-aging interventions, has never been more important. Yet while hundreds of geroprotectors have extended lifespan in animal models, none have yet been approved for widespread use in humans. GeroScope is a computational tool that can aid prediction of novel geroprotectors from existing human gene expression data. GeroScope maps expression differences between samples from young and old subjects to aging-related signaling pathways, then profiles pathway activation strength (PAS) for each condition...
September 24, 2016: Aging
https://www.readbyqxmd.com/read/27671164/analysis-of-allelic-imbalance-in-rice-hybrids-under-water-stress-and-association-of-asymmetrically-expressed-genes-with-drought-response-qtls
#8
Nelzo C Ereful, Li-Yu Liu, Eric Tsai, Shu-Min Kao, Shalabh Dixit, Ramil Mauleon, Katrina Malabanan, Michael Thomson, Antonio Laurena, David Lee, Ian Mackay, Andy Greenland, Wayne Powell, Hei Leung
BACKGROUND: Information on the effect of stress on the allele-specific expression (ASE) profile of rice hybrids is limited. More so, the association of allelically imbalanced genes to important traits is yet to be understood. Here we assessed allelic imbalance (AI) in the heterozygote state of rice under non- and water-stress treatments and determined association of asymmetrically expressed genes with grain yield (GY) under drought stress by in-silico co-localization analysis and selective genotyping...
December 2016: Rice
https://www.readbyqxmd.com/read/27629291/study-of-apoptosis-related-interactions-in-colorectal-cancer
#9
Himanshu Arora, Rehana Qureshi, M A Rizvi, Sharad Shrivastava, Mordhwaj S Parihar
Abnormalities in apoptotic functions contribute to the pathogenesis of colorectal cancer. In this study, molecular interactions behind the apoptotic regulation have been explored. For this purpose, enrichment analysis was performed considering microRNAs (miRNAs) that putatively target TP53 and altered during colon cancer. This revealed gene associated with both TP53 and miRNAs. Further analysis showed that a significant molecular interaction between the shortlisted candidates (TP53, miR-143, KRAS, BCL2, and PLK1) exists...
September 15, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27594838/in-vitro-effects-of-four-native-brazilian-medicinal-plants-in-cyp3a4-mrna-gene-expression-glutathione-levels-and-p-glycoprotein-activity
#10
Andre L D A Mazzari, Flora Milton, Samantha Frangos, Ana C B Carvalho, Dâmaris Silveira, Francisco de Assis Rocha Neves, Jose M Prieto
Erythrina mulungu Benth. (Fabaceae), Cordia verbenacea A. DC. (Boraginaceae), Solanum paniculatum L. (Solanaceae) and Lippia sidoides Cham. (Verbenaceae) are medicinal plant species native to Brazil shortlisted by the Brazilian National Health System for future clinical use. However, nothing is known about their effects in metabolic and transporter proteins, which could potentially lead to herb-drug interactions (HDI). In this work, we assess non-toxic concentrations (100 μg/mL) of the plant infusions for their in vitro ability to modulate CYP3A4 mRNA gene expression and intracellular glutathione levels in HepG2 cells, as well as P-glycoprotein (P-gp) activity in vincristine-resistant Caco-2 cells (Caco-2 VCR)...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27590716/computational-prediction-and-analysis-of-potential-antigenic-ctl-epitopes-in-zika-virus-a-first-step-towards-vaccine-development
#11
Manas R Dikhit, Md Yousuf Ansari, Vijaymahantesh, Kalyani, Rani Mansuri, Bikash R Sahoo, Budheswar Dehury, Ajay Amit, Roshan K Topno, Ganesh C Sahoo, Vahab Ali, Sanjiva Bimal, Pradeep Das
The Zika virus disease is an Aedes mosquito-borne disease caused by the ZIKA virus. The unavailability of vaccines or proper chemotherapeutic treatment emphasizes the need for the development of preventive and therapeutic vaccines. T cell specific epitopes have been used as vaccine candidates to generate desired immune responses against a variety of viral pathogens. Herein, the immune-informatics approach was used for the screening of potential major histocompatibility complex class I restricted epitopes, which may be competent to generate a cell-mediated immune response in humans...
August 31, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27590269/tilting-the-lasso-by-knowledge-based-post-processing
#12
Kukatharmini Tharmaratnam, Matthew Sperrin, Thomas Jaki, Sjur Reppe, Arnoldo Frigessi
BACKGROUND: It is useful to incorporate biological knowledge on the role of genetic determinants in predicting an outcome. It is, however, not always feasible to fully elicit this information when the number of determinants is large. We present an approach to overcome this difficulty. First, using half of the available data, a shortlist of potentially interesting determinants are generated. Second, binary indications of biological importance are elicited for this much smaller number of determinants...
2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27544001/management-of-parkinson-s-disease-in-ayurveda-medicinal-plants-and-adjuvant-measures
#13
Namyata Pathak-Gandhi, Ashok D B Vaidya
ETHNOPHARMACOLOGICAL RELEVANCE: Medicinal plants like Mucuna pruriens L.(DC) and Withania somnifera L.(Dunal) have been used in traditional Ayurvedic medicine to manage neurodegenerative diseases like Parkinson's disease. AIM: The aim of this review is to share the role of Ayurveda's insights, traditional usage and contemporary investigations for translational, integrative applications to manage Idiopathic Parkinson's Disease. MATERIALS AND METHODS: High impact journals for Parkinson's diseases, traditional textbooks from Ayurveda as well as relevant clinical and para clinical studies with botanicals are selectively incorporated to evolve the aforesaid translational application...
August 17, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27539764/available-interventions-for-prevention-of-cotton-dust-associated-lung-diseases-among-textile-workers
#14
Asaad Ahmed Nafees, Zafar Fatmi
The authors reviewed literature on interventions for cotton dust-associated lung diseases among textile workers. Internet sources (PubMed, Cochrane Library, Google and Google Scholar) were accessed and interventions were categorized into: Engineering or administrative controls, or personal protective equipment (PPE). Ten relevant articles were shortlisted, five related to engineering controls (pre-processing, bactericidal treatment of cotton, improved workplace design, machinery and dust control measures). Administrative controls may involve setting standards, environmental surveillance, periodic medical examinations, and workers training...
August 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27532070/one-log-in-to-a-wealth-of-health-resources
#15
Daloni Carlisle
NHS Education for Scotland has been shortlisted for a UK technology award for its programme of digital transformation and development of digital resources. It includes a new platform which is enabling nurses and midwives to take control of their professional development using their smartphones and tablets.
April 13, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27524925/systematic-review-of-measurement-properties-of-patient-reported-outcome-measures-used-in-patients-undergoing-hip-and-knee-arthroplasty
#16
REVIEW
Kristina Harris, Jill Dawson, Elizabeth Gibbons, Chris R Lim, David J Beard, Raymond Fitzpatrick, Andrew J Price
OBJECTIVES: To identify patient-reported outcome measures (PROMs) that have been developed and/or used with patients undergoing hip or knee replacement surgery and to provide a shortlist of the most promising generic and condition-specific instruments. METHODS: A systematic review of the literature was performed to identify measures used in patients undergoing hip and knee replacement and extract and evaluate information on their methodological quality. RESULTS: Thirty-two shortlisted measures were reviewed for the quality of their measurement properties...
2016: Patient related Outcome Measures
https://www.readbyqxmd.com/read/27507449/development-of-a-workflow-for-screening-and-identification-of-%C3%AE-amylase-inhibitory-peptides-from-food-source-using-an-integrated-bioinformatics-phage-display-approach-case-study-cumin-seed
#17
Hwee-Leng Siow, Theam Soon Lim, Chee-Yuen Gan
The main objective of this study was to develop an efficient workflow to discover α-amylase inhibitory peptides from cumin seed. A total of 56 unknown peptides was initially found in the cumin seed protein hydrolysate. They were subjected to 2 different in silico screenings and 6 peptides were shortlisted. The peptides were then subjected to in vitro selection using phage display technique and 3 clones (CSP3, CSP4 and CSP6) showed high affinity in binding α-amylase. These clones were subjected to the inhibitory test and only CSP4 and CSP6 exhibited high inhibitory activity...
January 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27491791/machine-learning-estimation-of-atom-condensed-fukui-functions
#18
Qingyou Zhang, Fangfang Zheng, Tanfeng Zhao, Xiaohui Qu, João Aires-de-Sousa
To enable the fast estimation of atom condensed Fukui functions, machine learning algorithms were trained with databases of DFT pre-calculated values for ca. 23,000 atoms in organic molecules. The problem was approached as the ranking of atom types with the Bradley-Terry (BT) model, and as the regression of the Fukui function. Random Forests (RF) were trained to predict the condensed Fukui function, to rank atoms in a molecule, and to classify atoms as high/low Fukui function. Atomic descriptors were based on counts of atom types in spheres around the kernel atom...
February 2016: Molecular Informatics
https://www.readbyqxmd.com/read/27478916/laryngopyocele-report-of-a-rare-case-and-systematic-review
#19
Syarifah N Al-Yahya, Marina Mat Baki, Sakina Mohd Saad, Mawaddah Azman, Abdullah Sani Mohamad
UNLABELLED: A systematic review on laryngopyoceles across Ovid, PubMed, and Google Scholar database was conducted. A total of 61 papers published between 1952 and 2015 were found. Of these, 23 cases written in English, which described the number of cases, surgical approaches, resort to tracheostomy, complications, and outcomes, were shortlisted. Four cases of laryngopyoceles were managed endoscopically using a cold instrument, microdebrider, or laser. Eighteen cases were operated via an external approach, and 1 case applied both approaches...
July 2016: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/27450181/screening-of-natural-products-and-derivatives-for-identification-of-rnd-efflux-pump-inhibitors
#20
Debarati Choudhury, Anupam Das Talukdar, Pankaj Chetia, Amitabha Bhattacharjee, Manabendra Dutta Choudhury
AIM AND OBJECTIVE: Overexpression of efflux pumps belonging to the Resistance Nodulation cell Division (RND) family is the most important intrinsic resistance mechanism of Pseudomonas aeruginosa. Hence, it is imperative to identify suitable efflux pump inhibitors (EPI) that can lead to increased intracellular concentration of antibiotics by blocking the pump. This study was undertaken to identify a putative plant based efflux pump inhibitor for RND efflux pump of P. aeruginosa. MATERIAL AND METHOD: Using molecular docking approach, 328 secondary plant metabolites have been screened for their inhibitory activity against cytoplasmic exporter protein MexB of MexAB-OprM efflux pump of P...
July 20, 2016: Combinatorial Chemistry & High Throughput Screening
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