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https://www.readbyqxmd.com/read/29234683/antioxidant-potential-of-selected-korean-edible-plant-extracts
#1
Yaejin Woo, Hyeji Lee, Yong-Seob Jeong, Ga Young Shin, Ja Gyeong Oh, Jong-Sang Kim, Jisun Oh
This study aimed to evaluate the antioxidant activity of various plant extracts. A total of 94 kinds of edible plant extracts obtained from the Korea Plant Extract Bank were screened for cytotoxicity, following which the total phenolic content of 24 shortlisted extracts was determined. Of these, extracts from three plants, namely, Castanea crenata (CC) leaf, Camellia japonica (CJ) fruit, and Viburnum dilatatum (VD) leaf, were examined for antioxidant capabilities by measuring radical scavenging activity, ferric reducing/antioxidant power, and lipid peroxidation inhibitory activity...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29229936/identification-of-a-gene-signature-for-discriminating-metastatic-from-primary-melanoma-using-a-molecular-interaction-network-approach
#2
Rahul Metri, Abhilash Mohan, Jérémie Nsengimana, Joanna Pozniak, Carmen Molina-Paris, Julia Newton-Bishop, David Bishop, Nagasuma Chandra
Understanding the biological factors that are characteristic of metastasis in melanoma remains a key approach to improving treatment. In this study, we seek to identify a gene signature of metastatic melanoma. We configured a new network-based computational pipeline, combined with a machine learning method, to mine publicly available transcriptomic data from melanoma patient samples. Our method is unbiased and scans a genome-wide protein-protein interaction network using a novel formulation for network scoring...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29228146/identification-and-characterization-of-a-specific-13-mirna-expression-signature-during-follicle-activation-in-the-zebrafish-ovary
#3
Queenie Wing-Lei Wong, Ming-An Sun, Shuk-Wa Lau, Chirag Parsania, Shaolong Zhou, Silin Zhong, Wei Ge
Ovarian folliculogenesis is always of great interest in reproductive biology. However, the molecular mechanisms that control follicle development, particularly the early phase of follicle activation or recruitment, still remain poorly understood. In an attempt to decipher the gene networks and signaling pathways involved in such transition, we conducted a transcriptomic analysis (RNA-seq) on zebrafish primary growth (PG, stage I; inactive) and pre-vitellogenic (PV, stage II; activated) follicles. A total of 118 unique microRNAs (miRNAs) (11 down-regulated and 83 up-regulated during PG/PV transition) and 56711 unique messenger RNAs (mRNAs) (1839 down-regulated and 7243 up-regulated during PG/PV transition) were identified...
December 6, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29222496/genome-wide-and-gene-based-association-mapping-for-rice-eating-and-cooking-characteristics-and-protein-content
#4
Xiaoqian Wang, Yunlong Pang, Jian Zhang, Zhichao Wu, Kai Chen, Jauhar Ali, Guoyou Ye, Jianlong Xu, Zhikang Li
Rice eating and cooking quality and protein content (PC) are important properties affecting consumers' preferences, nutrition and health. Linkage QTL mapping and association studies are usually applied to genetically dissect related traits, which could be further facilitated by high density SNP markers and gene annotation based on reference genome to rapid identify candidate genes associated with interested traits. Here, we carried out an association study for apparent amylose content (AC), gel consistency (GC), gelatinization temperature (GT) and PC evaluated in two environments using a diverse panel of 258 accessions from 3 K Rice Genome Project...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29220488/disentangling-immediate-adaptive-introgression-from-selection-on-standing-introgressed-variation-in-humans
#5
Evelyn Jagoda, Daniel J Lawson, Jeffrey D Wall, David Lambert, Craig Muller, Michael Westaway, Matthew Leavesley, Terence D Capellini, Marta Mirazón Lahr, Pascale Gerbault, Mark G Thomas, Andrea Bamberg Migliano, Eske Willerslev, Mait Metspalu, Luca Pagani
Recent studies have reported evidence suggesting that portions of contemporary human genomes introgressed from archaic hominin populations went to high frequencies due to positive selection. However, no study to date has specifically addressed the post-introgression population dynamics of these putative cases of adaptive introgression. Here, for the first time, we specifically define cases of immediate adaptive introgression (iAI), in which archaic haplotypes rose to high frequencies in humans as a result of a selective sweep that occurred shortly after the introgression event...
December 6, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29183384/core-health-outcomes-in-childhood-epilepsy-choice-protocol-for-the-selection-of-a-core-outcome-set
#6
Christopher Morris, Colin Dunkley, Frances M Gibbon, Janet Currier, Deborah Roberts, Morwenna Rogers, Holly Crudgington, Lucy Bray, Bernie Carter, Dyfrig Hughes, Catrin Tudur Smith, Paula R Williamson, Paul Gringras, Deb K Pal
BACKGROUND: There is increasing recognition that establishing a core set of outcomes to be evaluated and reported in trials of interventions for particular conditions will improve the usefulness of health research. There is no established core outcome set for childhood epilepsy. The aim of this work is to select a core outcome set to be used in evaluative research of interventions for children with rolandic epilepsy, as an exemplar of common childhood epilepsy syndromes. METHODS: First we will identify what outcomes should be measured; then we will decide how to measure those outcomes...
November 28, 2017: Trials
https://www.readbyqxmd.com/read/29177214/how-to-get-shortlisted-for-medical-jobs
#7
Buket Gundogan, Kiron Koshy, Katharine Whitehurst, Alex Fowler, Riaz Agha
Progressing up the medical career ladder is a tough business. Most medical and surgical applications center the requirement for a holistic, balanced individual. As a result, there are usually specific marking criteria in predefined sections. This article provides a guide into what employers are looking for and how best to build your portfolio in these areas.
July 2017: International Journal of Surgery. Oncology
https://www.readbyqxmd.com/read/29174549/identification-and-characterization-of-potential-druggable-targets-among-hypothetical-proteins-of-extensively-drug-resistant-mycobacterium-tuberculosis-xdr-kzn-605-through-subtractive-genomics-approach
#8
Reaz Uddin, Quratulain Nehal Siddiqui, Syed Sikander Azam, Bibi Saima, Abdul Wadood
Among the resistant isolates of tuberculosis (TB), the multidrug resistance tuberculosis (MDR-TB) and extensively drug resistant tuberculosis (XDR-TB) are the areas of growing concern for which the front-line antibiotics are no more effective. As a result, the search of new therapeutic targets against TB is an imperative need of time. On the other hand, the target identification is an a priori step in drug discovery based research. Furthermore, the availability of the complete proteomic data of extensively drug resistant Mycobacterium tuberculosis (XDR-MTB) made it possible to carry out in silico analysis for the discovery of new drug targets...
November 22, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29173828/employing-patient-reported-outcome-pro-measures-to-support-newly-diagnosed-patients-with-melanoma-feasibility-and-acceptability-of-a-holistic-needs-assessment-intervention
#9
Grigorios Kotronoulas, John Connaghan, Jean Grenfell, Girish Gupta, Leigh Smith, Mhairi Simpson, Roma Maguire
PURPOSE: Living with a melanoma diagnosis can be challenging. We aimed to assess the feasibility, acceptability, and perceived value of a nurse-led intervention that utilised patient-reported outcome (PRO) measures to identify and address the supportive care needs of newly diagnosed patients with Stage I/II melanoma over the first 4 months post-diagnosis. METHODS: We conducted an exploratory, repeated-measures, single-arm, feasibility trial. One baseline (4 weeks post-diagnosis; T1) and one follow-up intervention session (4 weeks after wide local excision; T3) took place, two months apart...
December 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29115992/role-of-mhealth-applications-for-improving-antenatal-and-postnatal-care-in-low-and-middle-income-countries-a-systematic-review
#10
Anam Feroz, Shagufta Perveen, Wafa Aftab
BACKGROUND: From 1990 to 2015, the number of maternal deaths globally has dropped by 43%. Despite this, progress in attaining MDG 5 is not remarkable in LMICs. Only 52% of pregnant women in LMICs obtain WHO recommended minimum of four antenatal consultations and the coverage of postnatal care is relatively poor. In recent years, the increased cellphone penetration has brought the potential for mHealth to improve preventive maternal healthcare services. The objective of this review is to assess the effectiveness of mHealth solutions on a range of maternal health outcomes by categorizing the interventions according to the types of mHealth applications...
November 7, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29112451/2016-lush-science-prize
#11
Jenny McCann, Terry McCann
The Lush Prize supports animal-free testing by awarding monetary prizes totalling £250,000 to the most effective projects and individuals who have been working toward the goal of replacing animals in product or ingredient safety testing. Prizes are awarded for developments in five strategic areas: Science; Lobbying; Training; Public Awareness; and Young Researchers. In the event of a major breakthrough leading to the replacement of animal tests in the area of 21st Century Toxicology, a Black Box Prize (equivalent to the entire annual fund of £250,000) is awarded...
November 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/29096381/epitopes-based-drug-design-for-dengue-virus-envelope-protein-a-computational-approach
#12
Abdul Wadood, Aamir Mehmood, Huma Khan, Muhammad Ilyas, Ayaz Ahmad, Mohammed Alarjah, Tareq Abu-Izneid
Dengue virus (DENV) has emerged as a rapidly spreading epidemic throughout the tropical and subtropical regions around the globe. No suitable drug has been designed yet to fight against DENV, therefore, the need for safe and effective antiviral drug has become imperative. The envelope protein of DENV is responsible for mediating the fusion process between viral and host membranes. This work reports an in silico approach to target B and T cell epitopes for dengue envelope protein inhibition. A conserved region "QHGTI" in B and T cell epitopes of dengue envelope glycoprotein was confirmed to be valid for targeting by visualizing its interactions with the host cell membrane TIM-1 protein which acts as a receptor for serotype 2 and 3...
October 20, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29072223/telomerase-an-exploration-toward-the-end-of-cancer
#13
REVIEW
Deepika Bablani Popli, Keya Sircar, Aman Chowdhry
BACKGROUND: The distinguishing feature of cancer cells is their ability to proliferate indefinitely, which is in contrast to the restricted cell multiplication potential for somatic cells. A better understanding of this contrasting behavior was provided in the early 1990s with the discovery of a relationship between telomeres, telomerase, aging, and cancer. Telomeres (tandem repeat DNA sequence TTAGGG) are protective caps at the ends of human chromosomes. Normal human cells experience telomere shortening with each successive cell division...
September 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29066912/identification-of-key-pathways-and-genes-with-aberrant-methylation-in-prostate-cancer-using-bioinformatics-analysis
#14
Anshika N Singh, Neeti Sharma
Prostate cancer (PCa), a multifocal clinically heterogeneous disease, is the most commonly diagnosed non-cutaneous neoplasm in men worldwide. The epigenome of PCa is a typical representation of catastrophic model of epigenetic alterations during tumorigenesis and its progression. Alterations in methylation patterns in tumor suppressors, cell cycle, oncogenes and metabolism-related genes are the most commonly observed epigenetic alterations in PCa. In this study, we have developed a computational strategy to identify methylated biomarker signature panels as potential targets of PCa by screening >160 genes reported to be epigenetically dysregulated, and shortlisted 26 differentially methylated genes (DMGs) that significantly contribute to oncogenesis...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29063569/making-sense-of-big-textual-data-for-health-care-findings-from-the-section-on-clinical-natural-language-processing
#15
A Névéol, P Zweigenbaum
Objectives: To summarize recent research and present a selection of the best papers published in 2016 in the field of clinical Natural Language Processing (NLP). Method: A survey of the literature was performed by the two section editors of the IMIA Yearbook NLP section. Bibliographic databases were searched for papers with a focus on NLP efforts applied to clinical texts or aimed at a clinical outcome. Papers were automatically ranked and then manually reviewed based on titles and abstracts. A shortlist of candidate best papers was first selected by the section editors before being peer-reviewed by independent external reviewers...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29063540/findings-from-the-2017-yearbook-section-on-health-information-management
#16
M Bloomrosen, E S Berner
Objectives: To summarize the recent literature and research and present a selection of the best papers published in 2016 in the field of Health Information Management (HIM). Methods: A systematic review of the literature for the IMIA Yearbook HIM section was performed by the two section editors with the help of a medical librarian. We searched bibliographic databases for HIM-related papers were searched using both MeSH headings and key words in titles and abstracts. A shortlist of candidate best papers was first selected by section editors before being peer-reviewed by independent external reviewers...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29063539/findings-from-the-2017-yearbook-section-on-health-information-management
#17
M Bloomrosen, E S Berner
Objectives: To summarize the recent literature and research and present a selection of the best papers published in 2016 in the field of Health Information Management (HIM). Methods: A systematic review of the literature for the IMIA Yearbook HIM section was performed by the two section editors with the help of a medical librarian. We searched bibliographic databases for HIM-related papers were searched using both MeSH headings and key words in titles and abstracts. A shortlist of candidate best papers was first selected by section editors before being peer-reviewed by independent external reviewers...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29054654/assessing-the-potential-impacts-of-a-revised-set-of-on-farm-nutrient-and-sediment-basic-control-measures-for-reducing-agricultural-diffuse-pollution-across-england
#18
A L Collins, J P Newell Price, Y Zhang, R Gooday, P S Naden, D Skirvin
The need for improved abatement of agricultural diffuse water pollution represents cause for concern throughout the world. A critical aspect in the design of on-farm intervention programmes concerns the potential technical cost-effectiveness of packages of control measures. The European Union (EU) Water Framework Directive (WFD) calls for Programmes of Measures (PoMs) to protect freshwater environments and these comprise 'basic' (mandatory) and 'supplementary' (incentivised) options. Recent work has used measure review, elicitation of stakeholder attitudes and a process-based modelling framework to identify a new alternative set of 'basic' agricultural sector control measures for nutrient and sediment abatement across England...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29044522/an-automated-two-dimensional-form-registration-method-for-osteological-pair-matching
#19
Jeffrey James Lynch
This study introduces an automated method for osteological pair-matching using two-dimensional outline form data extracted from photographs. A procedure for acquiring photographs that improve the differentiation of specimens from the background is presented along with an extraction procedure that allows the capture of form data from photographs. The raw form data are used in a two-dimensional registration procedure, which combines iterative closest point, K-nearest neighbor search, and iterations around an estimated mean...
October 16, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29039247/high-throughput-in-silico-identification-and-characterization-of-plasmodium-falciparum-prl-phosphatase-inhibitors
#20
Rajan Pandey, Rakesh Kumar, Priya Gupta, Asif Mohmmed, Rita Tewari, Pawan Malhotra, Dinesh Gupta
Kinases and phosphatases are involved in many essential processes in Plasmodium life cycle. Among the identified 67 Plasmodium falciparum phosphatases, Phosphatase of Regenerating Liver (PRL) family protein homolog, PfPRL is an essential parasite tyrosine phosphatase. PfPRL is shown to be prenylated, secreted and involved in the host invasion process. In the present study, a structure based high throughput in-silico screening of PfPRL binders, using ChEMBL-NTD compounds lead to the identification of nine compounds based on binding energy, Lipinski rule of five and QED score...
October 17, 2017: Journal of Biomolecular Structure & Dynamics
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