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https://www.readbyqxmd.com/read/28820895/identification-of-leishmania-donovani-antigen-in-circulating-immune-complexes-of-visceral-leishmaniasis-subjects-for-diagnosis
#1
Fauzia Jamal, Pushkar Shivam, Sarita Kumari, Manish Kumar Singh, Abul Hasan Sardar, Pushpanjali, Selvasankar Murugesan, Shyam Narayan, Anil Kumar Gupta, Krishna Pandey, V N R Das, Vahab Ali, Sanjiva Bimal, Pradeep Das, Shubhankar K Singh
The unreliability of most of the existing antibody-based diagnostic kits to discriminate between active and treated VL cases, relapse situation and reinfection are a major hurdle in controlling the cases of Kala-azar in an endemic area. An antigen targeted diagnostic approaches can be an attractive strategy to overcome these problems. Hence, this study was focused on identifying the Leishmania antigens, lies in circulating immune complex (CICs), can be used for diagnostic as well as prognostic purposes. The present study was conducted on peripheral blood samples of 115 human subjects, based on isolation of CICs...
2017: PloS One
https://www.readbyqxmd.com/read/28765241/a-multicenter-nominal-group-study-to-rank-outcomes-important-to-patients-and-their-representation-in-existing-composite-outcome-measures-for-psoriatic-arthritis
#2
William Tillett, Emma Dures, Sarah Hewlett, Philip S Helliwell, Oliver FitzGerald, Melanie Brooke, Jana James, Jane Lord, Clive Bowen, Martin de Wit, Ana-Maria Orbai, Neil McHugh
OBJECTIVE: To rank outcomes identified as important to patients with psoriatic arthritis (PsA) and examine their representation in existing composite measures. METHODS: Seven nominal group technique (NGT) meetings took place at 4 hospital sites. Two sorting rounds were conducted to generate a shortlist of outcomes followed by a group discussion and final ranking. In the final ranking round, patients were given 15 points each and asked to rank their top 5 outcomes from the shortlist...
August 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28730892/a-systematic-review-of-peer-mentoring-interventions-for-people-with-traumatic-brain-injury
#3
Richard Pg Morris, Joanna C Fletcher-Smith, Kathryn A Radford
OBJECTIVE: This systematic review sought evidence concerning the effectiveness of peer mentoring for people with traumatic brain injury. DATA SOURCES: Fourteen electronic databases were searched, including PsycINFO, MEDLINE, CINAHL, EMBASE and the Cochrane Library, from inception to September 21 2016. Ten grey literature databases, PROSPERO, two trials registers, reference lists and author citations were also searched. REVIEW METHODS: Studies which employed a model of one-to-one peer mentoring between traumatic brain injury survivors were included...
August 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28720258/feasibility-and-acceptability-of-the-use-of-patient-reported-outcome-measures-proms-in-the-delivery-of-nurse-led-supportive-care-to-people-with-colorectal-cancer
#4
Grigorios Kotronoulas, Constantina Papadopoulou, Lorna MacNicol, Mhairi Simpson, Roma Maguire
PURPOSE: Logistical issues pertinent to the use of patient-reported outcome measures (PROMs) by colorectal cancer nurse specialists (CNS) to identify the needs of people with colorectal cancer (CRC) in acute care remain unknown. We explored the feasibility and acceptability of PROMs-driven, CNS-led consultations to enhance delivery of supportive care to people with CRC completing adjuvant chemotherapy. METHODS: A systematic literature review and focus groups with patients and CNS (Phase 1) were followed by a repeated-measures, exploratory study (Phase 2), whereby pre-consultation PROM data were collected during three consecutive, monthly consultations, and used by the CNS to enable delivery of personalised supportive care...
August 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28706090/improving-site-selection-in-clinical-studies-a-standardised-objective-multistep-method-and-first-experience-results
#5
Anahí Hurtado-Chong, Alexander Joeris, Denise Hess, Michael Blauth
INTRODUCTION: A considerable number of clinical studies experience delays, which result in increased duration and costs. In multicentre studies, patient recruitment is among the leading causes of delays. Poor site selection can result in low recruitment and bad data quality. Site selection is therefore crucial for study quality and completion, but currently no specific guidelines are available. MATERIAL AND METHODS: Selection of sites adequate to participate in a prospective multicentre cohort study was performed through an open call using a newly developed objective multistep approach...
July 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28699213/acetamide-derivatives-of-chromen-2-ones-as-potent-cholinesterase-inhibitors
#6
Suchita Prasad, Bipul Kumar, Shiv Kumar, Karam Chand, Shashank S Kamble, Hemant K Gautam, Sunil K Sharma
Alzheimer's disease (AD), a neurodegenerative disorder, is a serious medical issue worldwide with drastic social consequences. Inhibition of cholinesterase is one of the rational and effective approaches to retard the symptoms of AD and, hence, consistent efforts are being made to develop efficient anti-cholinesterase agents. In pursuit of this, a series of 19 acetamide derivatives of chromen-2-ones were synthesized and evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory potential...
July 12, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/28677832/medical-identification-or-alert-jewellery-an-opportunity-to-save-lives-or-an-unreliable-hindrance
#7
REVIEW
S Rahman, D Walker, P Sultan
Medical identification jewellery can convey vital information to emergency responders, but mistakes and ambiguity may lead to misdiagnosis and morbidity. We performed a review of relevant articles retrieved from Pubmed(®) , Embase(®) and Scopus(®) and Google UK Inc. to investigate the commercial availability and issuance of these products. From 84 identified studies, we shortlisted 74 for review. The Google search retrieved 1,090,000 results within 0.57 s (January 2017). We explored 32 websites selling medical alert jewellery in the first five pages of these results...
July 5, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28664814/nicola-wood-s-achievements-can-help-inspire-others
#8
(no author information available yet)
The RCNi Nurse Awards ceremony is a showcase of talent and achievement that lives on beyond the event. Many of this year's shortlisted entries in the Nursing Older People category are examples of practice by nurses who are unafraid of challenging established ways of working or of championing improved outcomes for older people.
June 30, 2017: Nursing Older People
https://www.readbyqxmd.com/read/28663752/identification-and-characterization-of-mirna-transcriptome-in-asiatic-cotton-gossypium-arboreum-using-high-throughput-sequencing
#9
Muhammad Farooq, Shahid Mansoor, Hui Guo, Imran Amin, Peng W Chee, M Kamran Azim, Andrew H Paterson
MicroRNAs (miRNAs) are small 20-24nt molecules that have been well studied over the past decade due to their important regulatory roles in different cellular processes. The mature sequences are more conserved across vast phylogenetic scales than their precursors and some are conserved within entire kingdoms, hence, their loci and function can be predicted by homology searches. Different studies have been performed to elucidate miRNAs using de novo prediction methods but due to complex regulatory mechanisms or false positive in silico predictions, not all of them express in reality and sometimes computationally predicted mature transcripts differ from the actual expressed ones...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28637770/analgesia-and-opioids-a-pharmacogenetics-shortlist-for-implementation-in-clinical-practice
#10
REVIEW
Maja Matic, Saskia N de Wildt, Dick Tibboel, Ron H N van Schaik
BACKGROUND: The use of opioids to alleviate pain is complicated by the risk of severe adverse events and the large variability in dose requirements. Pharmacogenetics (PGx) could possibly be used to tailor pain medication based on an individual's genetic background. Many potential genetic markers have been described, and the importance of genetic predisposition in opioid efficacy and toxicity has been demonstrated in knockout mouse models and human twin studies. Such predictors are especially of value for neonates and young children, in whom the assessment of efficacy or side effects is complicated by the inability of the patient to communicate this properly...
July 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28607805/simplified-microsatellite-instability-detection-protocol-provides-equivalent-sensitivity-to-robust-detection-strategies-in-lynch-syndrome-patients
#11
Hadi Babaei, Mehrdad Zeinalian, Mohammad Hassan Emami, Mortaza Hashemzadeh, Najmeh Farahani, Rasoul Salehi
OBJECTIVE: : Germline mutations in mismatch repair (MMR) genes cause Lynch syndrome (LS). LS is an inherited disease, and an important consequence of MMR deficiency is microsatellite instability (MSI) phenotype. MSI phenotype influences the efficacy of 5 fluorouracil (5-FU) chemotherapy. Reproducible, cost effective, and easy to perform laboratory tests are required to include MSI detection in routine laboratory practice. Evaluation of CAT25 as monomorphic short tandem repeat sequence enables CAT25 to be an efficient screening tool among hereditary nonpolyposis colorectal cancer (HNPCC) patients compared with other methods used currently...
May 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28585374/svmdlf-a-novel-r-based-web-application-for-prediction-of-dipeptidyl-peptidase-4-inhibitors
#12
Sharat Chandra, Jyotsana Pandey, Akhilesh K Tamrakar, Mohammad Imran Siddiqi
Dipeptidyl peptidase 4 (DPP4) is a well-known target for the antidiabetic drugs. However, currently available DPP4 inhibitor screening assays are costly and labor-intensive. It is important to create a robust in-silico method to predict the activity of DPP4 inhibitor for the new lead finding. Here, we introduce a R based web application SVMDLF (SVM based DPP4 Lead Finder) to predict the inhibitor of DPP4; based on support vector machine (SVM) model, predictions of which are confirmed by in-vitro biological evaluation...
June 6, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28558816/intraoperative-electromyographic-monitoring-to-optimize-safe-lumbar-pedicle-screw-placement-a-retrospective-analysis
#13
Arun-Kumar Kaliya-Perumal, Jiun-Ran Charng, Chi-Chien Niu, Tsung-Ting Tsai, Po-Liang Lai, Lih-Huei Chen, Wen-Jer Chen
BACKGROUND: The foremost concern of a surgeon during pedicle screw fixation is safety. Assistive modalities, especially intraoperative electromyographic monitoring (EMG) can function as an essential tool to recognize screw malposition that compromise neural integrity, so that the screws can be repositioned immediately rather than later. We intend to study the efficacy of intraoperative EMG monitoring to detect potential pedicle breach and evaluate whether reoperation rates were significantly reduced...
May 30, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28554931/developing-a-core-outcome-set-for-infant-colic-for-primary-secondary-and-tertiary-care-settings-a-prospective-study
#14
Nina F Steutel, Marc A Benninga, Miranda W Langendam, Judith J Korterink, Flavia Indrio, Hania Szajewska, Merit M Tabbers
OBJECTIVE: Infant colic (IC) is defined as recurrent and prolonged crying without an obvious cause or evidence of failure to thrive or illness. It is a common problem with a prevalence of 5%-25%. The unknown aetiology results in a wide variety in interventions and use of heterogeneous outcome measures across therapeutic trials. Our aim was to develop a core outcome set (COS) for IC to facilitate and improve evidence synthesis. DESIGN AND SETTING: Prospective study design; primary, secondary and tertiary care...
May 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28554921/selection-by-a-panel-of-clinicians-and-family-representatives-of-important-early-morbidities-associated-with-paediatric-cardiac-surgery-suitable-for-routine-monitoring-using-the-nominal-group-technique-and-a-robust-voting-process
#15
Christina Pagel, Katherine L Brown, Isobel McLeod, Helen Jepps, Jo Wray, Linda Chigaru, Andrew McLean, Tom Treasure, Victor Tsang, Martin Utley
OBJECTIVE: With survival following paediatric cardiac surgery improving, the attention of quality assurance and improvement initiatives is shifting to long-term outcomes and early surgical morbidities. We wanted to involve family representatives and a range of clinicians in selecting the morbidities to be measured in a major UK study. SETTING: Paediatric cardiac surgery services in the UK. PARTICIPANTS: We convened a panel comprising family representatives, paediatricians from referring centres, and surgeons and other clinicians from surgical centres...
May 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28487705/genome-wide-association-mapping-reveals-multiple-qtls-governing-tolerance-response-for-seedling-stage-chilling-stress-in-indica-rice
#16
Elssa Pandit, Swaleha Tasleem, Saumya R Barik, Durga P Mohanty, Deepak K Nayak, Shakti P Mohanty, Sujata Das, Sharat K Pradhan
Rice crop is sensitive to cold stress at seedling stage. A panel of population representing 304 shortlisted germplasm lines was studied for seedling stage chilling tolerance in indica rice. Six phenotypic classes were exposed to six low temperature stress regimes under control phenotyping facility to investigate response pattern. A panel of 66 genotypes representing all phenotypic classes was used for ensuring genetic diversity, population structure and association mapping for the trait using 58 simple sequence repeat (SSR) and 2 direct trait linked markers...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28477017/characterization-of-potential-driver-mutations-involved-in-human-breast-cancer-by-computational-approaches
#17
REVIEW
Barani Kumar Rajendran, Chu-Xia Deng
Breast cancer is the second most frequently occurring form of cancer and is also the second most lethal cancer in women worldwide. A genetic mutation is one of the key factors that alter multiple cellular regulatory pathways and drive breast cancer initiation and progression yet nature of these cancer drivers remains elusive. In this article, we have reviewed various computational perspectives and algorithms for exploring breast cancer driver mutation genes. Using both frequency based and mutational exclusivity based approaches, we identified 195 driver genes and shortlisted 63 of them as candidate drivers for breast cancer using various computational approaches...
July 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28473483/antibiotic-awareness-poster-makes-awards-shortlist
#18
(no author information available yet)
No abstract text is available yet for this article.
May 6, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28470390/biallelic-mutations-in-cyp24a1-or-slc34a1-as-a-cause-of-infantile-idiopathic-hypercalcemia-iih-with-vitamin-d-hypersensitivity-molecular-study-of-11-historical-iih-cases
#19
Ewa Pronicka, Elżbieta Ciara, Paulina Halat, Agnieszka Janiec, Marek Wójcik, Elżbieta Rowińska, Dariusz Rokicki, Paweł Płudowski, Ewa Wojciechowska, Aldona Wierzbicka, Janusz B Książyk, Agnieszka Jacoszek, Martin Konrad, Karl P Schlingmann, Mieczysław Litwin
Idiopathic infantile hypercalcemia (IIH) is a mineral metabolism disorder characterized by severe hypercalcemia, failure to thrive, vomiting, dehydration, and nephrocalcinosis. The periodical increase in incidence of IIH, which occurred in the twentieth century in the United Kingdom, Poland, and West Germany, turned out to be a side effect of rickets over-prophylaxis. It was recently discovered that the condition is linked to two genes, CYP24A1 and SLC34A1. The aim of the study was to search for pathogenic variants of the genes in adult persons who were shortlisted in infancy as IIH caused by "hypersensitivity to vit...
August 2017: Journal of Applied Genetics
https://www.readbyqxmd.com/read/28365592/cell-scientist-to-watch-victoria-sanz-moreno
#20
(no author information available yet)
Vicky Sanz-Moreno received her first degree in chemistry and later a master's degree in biochemistry from the University of Oviedo in Spain, followed by a PhD in chemical sciences in the laboratory of Piero Crespo at the University of Cantabria, awarded in 2002. After a short postdoc in the same lab funded by a Lady Tata Memorial Trust Fellowship, she moved to the Institute of Cancer Research in London as a CRUK and Marie Curie Intra-European Fellow to work with Chris Marshall. In 2008, she received the Applied Biosystems and EACR 40th Anniversary Research Award...
April 1, 2017: Journal of Cell Science
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