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JOURNAL ARTICLE
Cristina Jaén, Christopher Maute, Scott Mackin, Monica R Camacho, Diana Truran, Rachel Nosheny, Michael W Weiner, Pamela Dalton
BACKGROUND: Early identification of deficits in our ability to perceive odors is important as many normal (i.e., aging) and pathological (i.e., sinusitis, viral, neurodegeneration) processes can result in diminished olfactory function. To realistically enable population-level measurements of olfaction, validated olfaction tests must be capable of being administered outside the research laboratory and clinical setting. AIM: The purpose of this study was to determine the feasibility of remotely testing olfactory performance using a test that was developed with funding from the National Institutes of Health as part of a ready-to-use, non-proprietary set of measurements useful for epidemiologic studies (NIH Toolbox Odor ID Test)...
2024: PloS One
#22
JOURNAL ARTICLE
Amanda Clauwaert, Eleana A Pinto, Stijn Schouppe, Lieven Danneels, Jessica Van Oosterwijck, Stefaan Van Damme
Attention has been proposed to play an important role in persisting pain, with excessive attentional processes towards pain information leading to worse pain outcomes and maladaptive behaviors. Nevertheless, research on somatosensory attending during the anticipation of pain-related movements is still scarce. This study investigated if individuals with chronic and recurrent lower back pain compared to pain-free controls, show enhanced attending to somatosensory information in the back while anticipating back-recruiting movements...
2024: PloS One
#23
JOURNAL ARTICLE
S Marjolein van Cappellen, Hanneke E Creemers, Larissa Hoogsteder, Joan van Horn, Jessica J Asscher
BACKGROUND: Juvenile antisocial behavior can have long-lasting and devastating effects for juveniles themselves, victims, and society. Evidence-based treatment is vital. Forensic Outpatient Systemic Therapy (Forensische Ambulante Systeem Therapie; FAST) is a promising treatment for juveniles showing severe antisocial behavior including aggression, (domestic) violence, and delinquent behavior. FAST has a flexible intensity and length, addresses individual and systemic risk and protective factors, and is responsive to the abilities of the client (system), intervention characteristics all considered crucial for effective treatment...
2024: PloS One
#24
JOURNAL ARTICLE
Federico Pinna, Nicola Fois, Francesco Mura, Alberto Ruiu, Giulia Ceccherelli
Where sea urchin harvest has been so intense that populations have drastically regressed, concerns have arisen about the effectiveness of harvesting management. According to the theory of phase transition in shallow rocky reefs between vegetated and barren habitats, sea urchin recruitment, a key population structuring process, seems hampered by some stabilizing feedback despite an end to local human harvest of sea urchins. To shed a light on predation effects on sea urchin recruits, a 27-day field experiment was conducted using mega-predator exclusion cages (40x40x40 cm, 1 cm in mesh size) in barren and turf substrates...
2024: PloS One
#25
JOURNAL ARTICLE
Cheng Zhang, Wenmiao Liu, Lulu Xu, Shiguo Liu, Fengyuan Che
ASH1L potentially contributes to Tourette syndrome (TS) and other neuropsychiatric disorders, as our previous studies have shown. It regulates essential developmental genes by counteracting polycomb-mediated transcriptional repression, which restricts chromatin accessibility at target genes. ASH1L is highly expressed in the adult brain, playing a crucial role in the early stage. However, it remains unclear how ASH1L mutations carried by patients with TS participate in regulating neuronal growth processes leading to TS traits...
April 18, 2024: European Child & Adolescent Psychiatry
#26
JOURNAL ARTICLE
Jana Müller, Rhoda Meyer, Jason Bantjes, Elize Archer, Ian Couper
Issue: A significant component of health professions education is focussed on students' exposure to the social determinants of health and the challenges that patients within the health care system face. An appropriate way to provide such exposure is through distributed clinical training. This usually entails students training in smaller groups along the continuum of care, away from tertiary academic hospitals. This also means students are away from their existing academic and social support systems. It is evident that knowledge and clinical skills alone are not sufficient to prepare students, they also need to be taught to critically reflect on how their own values and attitudes traverse their knowledge and skills to influence their practice as healthcare professionals...
April 18, 2024: Teaching and Learning in Medicine
#27
JOURNAL ARTICLE
Claire André, Marie-Ève Martineau-Dussault, Andrée-Ann Baril, Nicola Andrea Marchi, Véronique Daneault, Dominique Lorrain, Carol Hudon, Célyne H Bastien, Dominique Petit, Cynthia Thompson, Judes Poirier, Jacques Montplaisir, Nadia Gosselin, Julie Carrier
STUDY OBJECTIVES: Apolipoprotein E ɛ4 (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD). In addition, APOE4 carriers may exhibit sleep disturbances, but conflicting results have been reported, such that there is no clear consensus regarding which aspects of sleep are impacted. Our objective was to compare objective sleep architecture between APOE4 carriers and non-carriers, and to investigate the modulating impact of age, sex, cognitive status and obstructive sleep apnea...
April 18, 2024: Sleep
#28
JOURNAL ARTICLE
Xiao-Qin Liu, Lan Wang, Xuan Gu, Xiao Shan, Juan Xie, Wen-Ying Gao, Yu-Hui Gu, Yan Zhang, Dong-Mei Gu
INTRODUCTION: Due to different social and cultural backgrounds, cervical cancer patients' experience of the treatment process and quality of life after treatment will be different. This study sought to gain in-depth understanding of the experiences of Chinese cervical cancer patients as regards their quality of life and physical symptoms. METHODOLOGY: Semi-structured interviews were used to collect data. We recruited 15 women with cervical cancer in eastern China for in-depth interviews...
April 18, 2024: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
#29
JOURNAL ARTICLE
Siofra Bradley, Fhionna Moore, Fiona Duffy, Lili Clark, Tasha Suratwala, Pooky Knightsmith, Karri Gillespie-Smith
This study aimed to explore the impact of Autistic identity (i.e. feeling like you belong to the Autistic community), sensory profiles (e.g. being over or under responsive to sensations) and camouflaging behaviours (i.e. masking) on eating disorder symptoms in Autistic adults. 180 Autistic people were recruited from the community and NHS. The Autistic people completed online questionnaires measuring Autistic identity, sensory profiles, camouflaging behaviours, autistic traits and eating disorder symptoms. The analysis showed that higher levels of camouflaging behaviour predicted higher levels of eating disorder symptoms...
April 18, 2024: Autism: the International Journal of Research and Practice
#30
JOURNAL ARTICLE
Jon Allard, Adam Pollard, Richard Laugharne, Jamie Coates, Julia Wildfire-Roberts, Michelle Millward, Rohit Shankar
BACKGROUND: Recovery colleges provide personalised educational mental health support for people who self-refer. The research evidence supporting them is growing, with key components and the positive experiences of attendees reported. However, the quantitative outcome evidence and impact on economic outcomes is limited. AIMS: To evaluate the impact of attending a UK recovery college for students who receive a full educational intervention. METHOD: This is a pre- and post-intervention study, with predominantly quantitative methods...
April 18, 2024: BJPsych Open
#31
Chandramouli Krishnan, Thomas E Augenstein, Edward S Claflin, Courtney R Hemsley, Edward P Washabaugh, Rajiv Ranganathan
BACKGROUND: The ability to relearn a lost skill is critical to motor recovery after a stroke. Previous studies indicate that stroke typically affects the processes underlying motor control and execution but not the learning of those skills. However, these prior studies could have been confounded by the presence of significant motor impairments and/or have not focused on motor acuity tasks (i.e., tasks focusing on the quality of executed actions) that have direct functional relevance to rehabilitation...
April 3, 2024: medRxiv
#32
JOURNAL ARTICLE
Tamires Dos Santos Vieira, Flávia Vitorino Freitas, Luiz Cláudio Barreto Silva Neto, Aline Ribeiro Borçoi, Suzanny Oliveira Mendes, Amanda Sgrancio Olinda, Ivana Alece Arantes Moreno, Bárbara Risse Quaioto, Marcele Lorentz Mattos de Souza, Wagner Miranda Barbosa, Juliana Krüger Arpini, Bruna Pereira Sorroche, Julia de Assis Pinheiro, Anderson Barros Archanjo, Joaquim Gasparini Dos Santos, Lidia Maria Rebolho Batista Arantes, Daniela Rodrigues de Oliveira, Adriana Madeira Alvares da Silva
BACKGROUND: Dietary composition can modify gene expression, favoring the development of chronic diseases via epigenetic mechanisms. OBJECTIVE: Our study aimed to investigate the relationship between dietary patterns and NR3C1 gene methylation in users of the Brazilian Public Unified Health System (SUS). METHODS: We recruited 250 adult volunteers and evaluated their socioeconomic status, psychosocial characteristics, lifestyle, and anthropometrics...
2024: Frontiers in Nutrition
#33
JOURNAL ARTICLE
Valery Gunas, Oleksandr Maievskyi, Tatyana Synelnyk, Nataliia Raksha, Tetiana Vovk, Tetiana Halenova, Olexiy Savchuk, Igor Gunas
Nowadays, more than two billion inhabitants of underdeveloped tropical and subtropical countries are at risk of being stung by scorpions. Scorpion stings annually cause 2000-3000 deaths as they can lead to the respiratory and/or cardiovascular complications. Pathogenesis of lung damage under scorpion envenomation is often comprehensive. Respiratory failure can have a cardiogenic origin, associated with venom neurotoxin action. However, some venom components can stimulate pro-inflammatory signaling cascades followed by cytokines synthesis, recruit and activate immune cells, participating in the inflammatory response in lung injury...
June 2024: Toxicon: X
#34
JOURNAL ARTICLE
Shelby E McDonald, Lori R Kogan, Nichole L Nageotte, Jennifer Currin-McCulloch, Rachel Dickler-Mann
INTRODUCTION: Burnout and mental health among animal care and health professionals (ACHPs) has received increasing attention in recent years. Despite rapid growth of research in this area, the wellbeing of individuals who work and/or volunteer in zoo settings has received minimal attention. METHOD: An anonymous online survey was created to evaluate zoo staff and volunteers' experiences of animal-related loss, rates of professional fulfillment and burnout, mental health, perceived organizational support, and resilience...
2024: Frontiers in Psychiatry
#35
JOURNAL ARTICLE
Léa Solh Dost, Giacomo Gastaldi, Marcelo Dos Santos Mamed, Marie P Schneider
BACKGROUND: The transition from hospital to outpatient care is a particularly vulnerable period for patients as they move from regular health monitoring to self-management. This study aimed to map and investigate the journey of patients with polymorbidities, including type 2 diabetes (T2D), in the 2 months following hospital discharge and examine patients' encounters with healthcare professionals (HCPs). METHODS: Patients discharged with T2D and at least two other comorbidities were recruited during hospitalization...
April 17, 2024: BMC Health Services Research
#36
JOURNAL ARTICLE
Karin Eli, Jenny Harlock, Caroline J Huxley, Celia Bernstein, Claire Mann, Rachel Spencer, Frances Griffiths, Anne-Marie Slowther
BACKGROUND: The Recommended Summary Plan for Emergency Care and Treatment (ReSPECT) was launched in the UK in 2016. ReSPECT is designed to facilitate meaningful discussions between healthcare professionals, patients, and their relatives about preferences for treatment in future emergencies; however, no study has investigated patients' and relatives' experiences of ReSPECT in the community. OBJECTIVES: To explore how patients and relatives in community settings experience the ReSPECT process and engage with the completed form...
April 17, 2024: BMC Prim Care
#37
JOURNAL ARTICLE
Anna Deal, Alison F Crawshaw, Maha Salloum, Sally E Hayward, Jessica Carter, Felicity Knights, Farah Seedat, Oumnia Bouaddi, Nuria Sanchez-Clemente, Laura Muzinga Lutumba, Lusau Mimi Kitoko, Sarah Nkembi, Caroline Hickey, Sandra Mounier-Jack, Azeem Majeed, Sally Hargreaves
BACKGROUND: The World Health Organization's (WHO) Immunization Agenda 2030 emphasises ensuring equitable access to vaccination across the life course. This includes placing an emphasis on migrant populations who may have missed key childhood vaccines, doses, and boosters due to disrupted healthcare systems and the migration process, or differing vaccination schedules in home countries. Guidelines exist in the UK for offering catch-up vaccinations to adolscent and adult migrants with incomplete or uncertain vaccination status (including MMR, Td-IPV, MenACWY, HPV), but emerging evidence suggests awareness and implementation in primary care is poor...
April 16, 2024: Vaccine
#38
JOURNAL ARTICLE
Julie K Wisch, Nicole S McKay, Anna H Boerwinkle, James Kennedy, Shaney Flores, Benjamin L Handen, Bradley T Christian, Elizabeth Head, Mark Mapstone, Michael S Rafii, Sid E O'Bryant, Julie C Price, Charles M Laymon, Sharon J Krinsky-McHale, Florence Lai, H Diana Rosas, Sigan L Hartley, Shahid Zaman, Ira T Lott, Dana Tudorascu, Matthew Zammit, Adam M Brickman, Joseph H Lee, Thomas D Bird, Annie Cohen, Patricio Chrem, Alisha Daniels, Jasmeer P Chhatwal, Carlos Cruchaga, Laura Ibanez, Mathias Jucker, Celeste M Karch, Gregory S Day, Jae-Hong Lee, Johannes Levin, Jorge Llibre-Guerra, Yan Li, Francisco Lopera, Jee Hoon Roh, John M Ringman, Charlene Supnet-Bell, Christopher H van Dyck, Chengjie Xiong, Guoqiao Wang, John C Morris, Eric McDade, Randall J Bateman, Tammie L S Benzinger, Brian A Gordon, Beau M Ances
BACKGROUND: In people with genetic forms of Alzheimer's disease, such as in Down syndrome and autosomal-dominant Alzheimer's disease, pathological changes specific to Alzheimer's disease (ie, accumulation of amyloid and tau) occur in the brain at a young age, when comorbidities related to ageing are not present. Studies including these cohorts could, therefore, improve our understanding of the early pathogenesis of Alzheimer's disease and be useful when designing preventive interventions targeted at disease pathology or when planning clinical trials...
May 2024: Lancet Neurology
#39
JOURNAL ARTICLE
Bianca Brijnath, Rachel Muoio, Peter Feldman, Davina Ghersi, An-Wen Chan, Vivian Welch, Shaun Treweek, Heidi Green, Aaron M Orkin, Ebenezer Owusu-Addo
OBJECTIVE: Lack of ethnic diversity in trials may contribute to health disparities and to inequity in health outcomes. The primary objective was to investigate the experiences and perspectives of ethnically diverse populations about how to improve ethnic diversity in trials. STUDY DESIGN AND SETTING: Qualitative data were collected via 16 focus groups with participants from 21 ethnically diverse communities in Australia. Data collection took place between August and September 2022 in community-based settings in six capital cities: Sydney, Melbourne, Perth, Adelaide, Brisbane, and Darwin and one rural town: Bordertown (South Australia)...
April 15, 2024: Journal of Clinical Epidemiology
#40
JOURNAL ARTICLE
Chiara Tremolanti, Elisa Angeloni, Eleonora Da Pozzo, Lorenzo Germelli, Chiara Giacomelli, Eduardo Scalzi, Sabrina Taliani, Federico Da Settimo, Ayikoé-Guy Mensah-Nyagan, Claudia Martini, Barbara Costa
Mature oligodendrocytes (OLs) arise from oligodendrocyte precursor cells that, in case of demyelination, are recruited at the lesion site to remyelinate the axons and therefore restore the transmission of nerve impulses. It has been widely documented that exogenously administered steroid molecules are potent inducers of myelination. However, little is known about how neurosteroids produced de novo by OLs can impact this process. Here, we employed a human OL precursor cell line to investigate the role of de novo neurosteroidogenesis in the regulation of OLs differentiation, paying particular attention to the 18 kDa Translocator Protein (TSPO) which controls the rate-limiting step of the neurosteroidogenic process...
April 15, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
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