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https://www.readbyqxmd.com/read/28534650/functions-of-iqd-proteins-as-hubs-in-cellular-calcium-and-auxin-signaling-a-toolbox-for-shape-formation-and-tissue-specification-in-plants
#1
Katharina Bürstenbinder, Dipannita Mitra, Jakob Quegwer
Ca(2+) ions play pivotal roles as second messengers in intracellular signal transduction, and coordinate many biological processes. Changes in intracellular Ca(2+) levels are perceived by Ca(2+) sensors such as CaM/CML proteins, which transduce Ca(2+) signals into cellular responses by regulation of diverse target proteins. Insights into molecular functions of CaM targets are thus essential to understand the molecular and cellular basis of Ca(2+) signaling. During the last decade, IQD proteins emerged as the largest class of CaM targets in plants with mostly unknown functions...
May 23, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28533748/cerebral-dynamics-during-the-observation-of-point-light-displays-depicting-postural-adjustments
#2
Eduardo F Martins, Thiago Lemos, Ghislain Saunier, Thierry Pozzo, Daniel Fraiman, Claudia D Vargas
Objective: As highly social creatures, human beings rely part of their skills of identifying, interpreting, and predicting the actions of others on the ability of perceiving biological motion. In the present study, we aim to investigate the electroencephalographic (EEG) cerebral dynamics involved in the coding of postural control and examine whether upright stance would be codified through the activation of the temporal-parietal cortical network classically enrolled in the coding of biological motion. Design: We registered the EEG activity of 12 volunteers while they passively watched point light displays (PLD) depicting quiet stable (QB) and an unstable (UB) postural situations and their respective scrambled controls (QS and US)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28533141/common-and-distinctive-patterns-of-cognitive-dysfunction-in-children-with-benign-epilepsy-syndromes
#3
Dazhi Cheng, Xiuxian Yan, Zhijie Gao, Keming Xu, Xinlin Zhou, Qian Chen
BACKGROUND: Childhood absence epilepsy and benign childhood epilepsy with centrotemporal spikes are the most common forms of benign epilepsy syndromes. Although cognitive dysfunctions occur in children with both childhood absence epilepsy and benign childhood epilepsy with centrotemporal spikes, the similarity between their patterns of underlying cognitive impairments is not well understood. To describe these patterns, we examined multiple cognitive functions in children with childhood absence epilepsy and benign childhood epilepsy with centrotemporal spikes...
January 4, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28533084/gene-flow-and-genetic-drift-contribute-to-high-genetic-diversity-with-low-phylogeographical-structure-in-european-hoopoes-upupa-epops
#4
Erjia Wang, Rien E Van Wijk, Markus Santhosh Braun, Michael Wink
The Hoopoe (Upupa epops epops) breeds widely in Eurasia and most populations migrate to Africa during the boreal winter. To date, data regarding its phylogeography in Europe are missing. In this study, we investigated the phylogeography and population genetics of Hoopoes by means of mitochondrial DNA (mtDNA) sequencing as well as microsatellite genotyping. Our analyses revealed 32 haplotypes in the cytochrome c oxidase subunit I (COI) (269 individuals) and 50 haplotypes in cytochrome b (cyt b) (233 individuals)...
May 19, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28532509/barriers-and-facilitators-to-healthcare-professional-behaviour-change-in-clinical-trials-using-the-theoretical-domains-framework-a-case-study-of-a-trial-of-individualized-temperature-reduced-haemodialysis
#5
Justin Presseau, Brittany Mutsaers, Ahmed A Al-Jaishi, Janet Squires, Christopher W McIntyre, Amit X Garg, Manish M Sood, Jeremy M Grimshaw
BACKGROUND: Implementing the treatment arm of a clinical trial often requires changes to healthcare practices. Barriers to such changes may undermine the delivery of the treatment making it more likely that the trial will demonstrate no treatment effect. The 'Major outcomes with personalized dialysate temperature' (MyTEMP) is a cluster-randomised trial to be conducted in 84 haemodialysis centres across Ontario, Canada to investigate whether there is a difference in major outcomes with an individualized dialysis temperature (IDT) of 0...
May 22, 2017: Trials
https://www.readbyqxmd.com/read/28532471/perfusion-by-arterial-spin-labelling-following-single-dose-tadalafil-in-small-vessel-disease-pastis-study-protocol-for-a-randomised-controlled-trial
#6
Mathilde M H Pauls, Natasha Clarke, Sarah Trippier, Shai Betteridge, Franklyn A Howe, Usman Khan, Christina Kruuse, Jeremy B Madigan, Barry Moynihan, Anthony C Pereira, Debbie Rolfe, Egill Rostrup, Caroline E Haig, Thomas R Barrick, Jeremy D Isaacs, Atticus H Hainsworth
BACKGROUND: Cerebral small vessel disease is a common cause of vascular cognitive impairment in older people, with no licensed treatment. Cerebral blood flow is reduced in small vessel disease. Tadalafil is a widely prescribed phosphodiesterase-5 inhibitor that increases blood flow in other vascular territories. The aim of this trial is to test the hypothesis that tadalafil increases cerebral blood flow in older people with small vessel disease. METHODS/DESIGN: Perfusion by Arterial Spin labelling following Single dose Tadalafil In Small vessel disease (PASTIS) is a phase II randomised double-blind crossover trial...
May 22, 2017: Trials
https://www.readbyqxmd.com/read/28532470/health-care-professionals-attitudes-towards-evidence-based-medicine-in-the-workers-compensation-setting-a-cohort-study
#7
Nieke A Elbers, Robin Chase, Ashley Craig, Lyn Guy, Ian A Harris, James W Middleton, Michael K Nicholas, Trudy Rebbeck, John Walsh, Simon Willcock, Keri Lockwood, Ian D Cameron
BACKGROUND: Problems may arise during the approval process of treatment after a compensable work injury, which include excess paperwork, delays in approving services, disputes, and allegations of over-servicing. This is perceived as undesirable for injured people, health care professionals and claims managers, and costly to the health care system, compensation system, workplaces and society. Introducing an Evidence Based Medicine (EBM) decision tool in the workers' compensation system could provide a partial solution, by reducing uncertainty about effective treatment...
May 22, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28532202/experiences-of-establishing-an-academic-early-phase-clinical-trials-unit
#8
Sarah R Brown, Debbie Sherratt, Gill Booth, Julia Brown, Fiona Collinson, Walter Gregory, Louise Flanagan
BACKGROUND: Early phase trials are essential in drug development, determining appropriate dose levels and assessing preliminary activity. These trials are undertaken by industry and academia, with increasing collaborations between the two. There is pressure to perform these trials quickly, safely, and robustly. However, there are inherent differences between developing and managing early phase, compared to late phase, drug trials. This article describes an approach to establishing an academically led early phase trial portfolio, highlighting lessons learned and sharing experiences...
May 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28531783/prototypical-versus-contemporary-mediterranean-diet
#9
W Rizza, L De Gara, R Antonelli Incalzi, C Pedone
BACKGROUND AND AIMS: To investigate the evolution of the Mediterranean Diet (MD) in a delimited area of Southern Italy, by comparing the diet adopted 60-70 years ago (Prototypical Mediterranean Diet, PMD) with the contemporary one (Contemporary Mediterranean Diet, CMD), and to verify to what extent they fitted the recommendations of the Italian and the USDA dietary guidelines. METHODS: We recruited a total of 106 participants, divided in two groups. PMD group included 52 women aged >80 years, with a good cognitive function and full independence in basic and instrumental activities of daily living...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28530228/generic-decoding-of-seen-and-imagined-objects-using-hierarchical-visual-features
#10
Tomoyasu Horikawa, Yukiyasu Kamitani
Object recognition is a key function in both human and machine vision. While brain decoding of seen and imagined objects has been achieved, the prediction is limited to training examples. We present a decoding approach for arbitrary objects using the machine vision principle that an object category is represented by a set of features rendered invariant through hierarchical processing. We show that visual features, including those derived from a deep convolutional neural network, can be predicted from fMRI patterns, and that greater accuracy is achieved for low-/high-level features with lower-/higher-level visual areas, respectively...
May 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28529765/signals-of-vagal-circuits-engaging-with-akt1-in-%C3%AE-7-nachr-cd11b-cells-lessen-e-coli-and-lps-induced-acute-inflammatory-injury
#11
Caiqi Zhao, Xi Yang, Emily M Su, Yuanyuan Huang, Ling Li, Michael A Matthay, Xiao Su
Vagal circuits-α7 nAChR (α7 nicotinic acetylcholine receptor, coded by Chrna7) signaling utilizes spleen as a hub to dampen systemic inflammatory responses. Vagal innervations also extend to the distal airways and alveoli. Vagotomy and deficiency of α7 nAChR deteriorate E. coli and lipopolysaccharide (LPS)-induced acute lung inflammatory responses; however, the underlying mechanisms remain elusive. Here, we hypothesized that vagal circuits would limit splenic release and lung recruitment of α7 nAChR(+)CD11b(+) cells (CD11b is coded by Itgam, a surface marker of monocytes and neutrophils) via phosphorylation of AKT1 and that this process would define the severity of lung injury...
2017: Cell Discovery
https://www.readbyqxmd.com/read/28528773/apoe-moderates-compensatory-recruitment-of-neuronal-resources-during-working-memory-processing-in-healthy-older-adults
#12
Elisa Scheller, Jessica Peter, Lena V Schumacher, Jacob Lahr, Irina Mader, Christoph P Kaller, Stefan Klöppel
The APOE ε4 allele increases the risk for sporadic Alzheimer's disease and modifies brain activation patterns of numerous cognitive domains. We assessed cognitively intact older adults with a letter n-back task to determine if previously observed increases in ε4 carriers' working-memory-related brain activation are compensatory such that they serve to maintain working memory function. Using multiple regression models, we identified interactions of APOE variant and age in bilateral hippocampus independently from task performance: ε4 carriers only showed a decrease in activation with increasing age, suggesting high sensitivity of fMRI data for detecting changes in Alzheimer's disease-relevant brain areas before cognitive decline...
April 26, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28528342/an-insight-into-the-changes-in-skin-texture-and-properties-following-dietary-intervention-with-a-nutricosmeceutical-containing-a-blend-of-collagen-bioactive-peptides-and-antioxidants
#13
Licia Genovese, Andrea Corbo, Sara Sibilla
BACKGROUND: Skin aging is a multifactorial phenomenon which causes alterations in skin physiological functions and, most visibly, phenotypic changes. In particular, during the aging process, hyaluronic acid, collagen, and elastin fibers undergo structural and functional changes. AIMS: This study aimed to give an insight into the photo-protective benefits and efficacy of an oral liquid nutricosmeceutical containing collagen bioactive peptides and antioxidants to counteract the signs of aging...
May 20, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28528241/peripheral-zinc-and-neopterin-concentrations-are-associated-with-mood-severity-in-bipolar-disorder-in-a-gender-specific-manner
#14
Caitlin E Millett, Dahlia Mukherjee, Aubrey Reider, Adem Can, Maureen Groer, Dietmar Fuchs, Teodor T Postolache, Shannon L Kelleher, Erika F H Saunders
Bipolar disorder (BD) is a recurrent, episodic mood disorder for which there are no current diagnostic, prognostic or theranostic biomarkers. Two peripheral markers of the acute phase immune response, zinc and neopterin, are consistently associated with severity of depression in literature. Given gender differences in clinical presentation of BD and in inflammatory processes, we aimed to explore the interaction between gender and immune biomarkers to predict mood severity in BD. Participants with DSM IV BD I and II were recruited through the Pennsylvania Psychiatric Institute during an acute mood episode...
May 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28527986/the-temporal-and-spatial-brain-dynamics-of-automatic-emotion-regulation-in-children
#15
Charline Urbain, Julie Sato, Elizabeth W Pang, Margot J Taylor
Mechanisms for automatic emotion regulation (AER) are essential during childhood as they offset the impact of unwanted or negative emotional responses without drawing on limited attentional resources. Despite the importance of AER in improving the efficiency and flexibility of self-regulation, few research studies have investigated the underlying neurophysiological mechanisms. To fill this gap, we used magnetoencephalography (MEG) to investigate AER-related brain processes in 25 children (∼10 years old) who performed a go/no-go task that included an incidental exposure to faces containing socio-emotional cues...
May 17, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28527703/sperm-oocyte-contact-induces-outside-in-signaling-via-pyk2-activation
#16
Huizhen Wang, Jinping Luo, Carol Carlton, Lynda K McGinnis, William H Kinsey
Fertilization is a multi-step process that begins with plasma membrane interactions that enable sperm - oocyte binding followed by fusion of the sperm and oocyte plasma membranes. Once membrane fusion has occurred, sperm incorporation involves actin remodeling events within the oocyte cortex that allow the sperm head to penetrate the cortical actin layer and gain access to the ooplasm. Despite the significance for reproduction, the control mechanisms involved in gamete binding, fusion, and sperm incorporation are poorly understood...
May 17, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28527134/comparison-of-nurses-and-general-caregivers-knowledge-attitude-and-practice-on-medication-administration-process-and-their-distress-level-in-long-term-care-facilities-across-penang-kuala-lumpur-and-selangor-of-malaysia
#17
Balamurugan Tangiisuran, Sok Cin Tye, May Yen Leow, Rahmat Awang
AIM: Comparing nurses and general caregivers' knowledge, attitude, and practices (KAP) on medication administration process in long-term care (LTC) setting and an assessment of their stress, anxiety, and depression (SAD) level. METHODS: A cross-sectional survey was conducted among nurses and general caregivers working in LTC using a validated questionnaire. Consisting of demographic characteristics (Section 1); 40 questions on KAP (Section 2); and assessment of Depression, Anxiety, and Stress Scale (DASS-21) (Section 3)...
May 19, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28527017/juxtaglomerular-cell-phenotypic-plasticity
#18
REVIEW
Alexandre Góes Martini, A H Jan Danser
Renin is the first and rate-limiting step of the renin-angiotensin system. The exclusive source of renin in the circulation are the juxtaglomerular cells of the kidney, which line the afferent arterioles at the entrance of the glomeruli. Normally, renin production by these cells suffices to maintain homeostasis. However, under chronic stimulation of renin release, for instance during a low-salt diet or antihypertensive therapy, cells that previously expressed renin during congenital life re-convert to a renin-producing cell phenotype, a phenomenon which is known as "recruitment"...
May 19, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/28526621/electrophysiological-signatures-of-phonological-and-semantic-maintenance-in-sentence-repetition
#19
Jed A Meltzer, Aneta Kielar, Lilia Panamsky, Kira A Links, Tiffany Deschamps, Rosie C Leigh
Verbal short-term memory comprises resources for phonological rehearsal, which have been characterized anatomically, and for maintenance of semantic information, which are less understood. Sentence repetition tasks tap both processes interactively. To distinguish brain activity involved in phonological vs. semantic maintenance, we recorded magnetoencephalography during a sentence repetition task, incorporating three manipulations emphasizing one mechanism over the other. Participants heard sentences or word lists and attempted to repeat them verbatim after a 5-second delay...
May 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/28526413/tcr-crosslinking-promotes-crk-adaptor-protein-binding-to-tyrosine-phosphorylated-cd3%C3%AE-chain
#20
Guangyu Dong, Rachel Kalifa, Pulak Ranjan Nath, Sigal Gelkop, Noah Isakov
T cell antigen receptor (TCR) binding of a peptide antigen presented by antigen-presenting cells (APCs) in the context of surface MHC molecules initiates signaling events that regulate T cell activation, proliferation and differentiation. A key event in the activation process is the phosphorylation of the conserved tyrosine residues within the CD3 chain immunoreceptor tyrosine-based activation motifs (ITAMs), which operate as docking sites for SH2 domain-containing effector proteins. Phosphorylation of the CD3ζ ITAMs renders the CD3 chain capable of binding the ζ-chain associated protein 70 kDa (ZAP70), a protein tyrosine kinase that is essential for T cell activation...
May 16, 2017: Biochemical and Biophysical Research Communications
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