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https://www.readbyqxmd.com/read/29331936/influence-of-custom-foot-orthoses-on-venous-status-a-quasi-experimental-study
#1
Daniel López-López, Romeu Araújo, Marta Elena Losa-Iglesias, Ricardo Becerro-de-Bengoa-Vallejo, António Santos, David Rodríguez-Sanz, César Calvo-Lobo
BACKGROUND: Customized foot orthoses (CFO) have been widely accepted to reduce the frequency of foot problems and postural disorders. The purpose of the research was to compare the influence of CFO utilization on the venous status among healthy females and males. METHODS: This was a quasi-experimental study (NCT03329430), which included 20 healthy subjects that completed all the stages of the process. The subjects showed an age mean of 20.00 ± 1.62 years and were recruited in a foot and ankle specialist center...
January 5, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29331655/what-makes-it-so-difficult-for-nurses-to-coach-patients-in-shared-decision-making-a-process-evaluation
#2
Stephanie Anna Lenzen, Ramon Daniëls, Marloes Amantia van Bokhoven, Trudy van der Weijden, Anna Beurskens
BACKGROUND: Primary care nurses play a crucial role in coaching patients in shared decision making about goals and actions. This presents a challenge to practice nurses, who are frequently used to protocol-based working routines. Therefore, an approach was developed to support nurses to coach patients in shared decision making. OBJECTIVES: To investigate how the approach was implemented and experienced by practice nurses and patients. DESIGN: A process evaluation was conducted using quantitative and qualitative methods...
December 16, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29331421/hyperglycaemia-induced-mir-301a-promotes-cell-proliferation-by-repressing-p21-and-smad4-in-prostate-cancer
#3
Xiaojuan Li, Jun Li, Yi Cai, Shubin Peng, Jun Wang, Zhaoming Xiao, Yu Wang, Yiran Tao, Jun Li, Qu Leng, Dinglan Wu, Shaodong Yang, Ziliang Ji, Yuefu Han, Liren Li, Xin Gao, Chunxian Zeng, Xingqiao Wen
Hyperglycaemia promotes the development of Prostate cancer (PCa). However, the roles of miRNAs in this disease process and the underlying mechanisms are largely unknown. In this study, we recruited 391 PCa patients in China and found that PCa patients with high level blood glucose (≥100 mg/dL) trended to have high Gleason score (GS≥7). miRNA-301a levels were significantly higher in prostate cancer than that in normal prostate tissues. Hyperglycaemia or high glucose treatment induced miR-301a expression in prostate tissues or PCa cell lines...
January 10, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29331168/dietary-patterns-and-their-associations-with-home-food-availability-among-finnish-pre-school-children-a-cross-sectional-study
#4
Henna Vepsäläinen, Liisa Korkalo, Vera Mikkilä, Reetta Lehto, Carola Ray, Kaija Nissinen, Essi Skaffari, Mikael Fogelholm, Leena Koivusilta, Eva Roos, Maijaliisa Erkkola
OBJECTIVE: To study the associations between home food availability and dietary patterns among pre-school children. DESIGN: Cross-sectional study in which parents of the participating children filled in an FFQ and reported how often they had certain foods in their homes. We derived dietary pattern scores using principal component analysis, and composite scores describing the availability of fruits and vegetables as well as sugar-enriched foods in the home were created for each participant...
January 14, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29331000/evaluation-of-peer-assisted-learning-in-evidence-based-medicine-course-a-pilot-study-at-university-of-glasgow
#5
Syed Hamid Habib, Muhammad Omar Malik, Sadia Fatima, Inayat Shah
BACKGROUND: Peer Assisted Learning (PAL) is a well-established approach in learning and is increasingly being utilized in the medical education system. It is a process where active help of peer group members is taken for learning. This study aimed to look at the impact of peer assisted learning on the students at the end of the session. METHODS: Sixteen Postgraduate students attending Evidence Based Medicine (EBM) course spanning over two semesters (6 months each) were recruited...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29329559/simplification-of-medications-prescribed-to-long-term-care-residents-simpler-study-protocol-for-a-cluster-randomised-controlled-trial
#6
Janet K Sluggett, Esa Y H Chen, Jenni Ilomäki, Megan Corlis, Sarah N Hilmer, Jan Van Emden, Choon Ean Ooi, Kim-Huong Nguyen, Tracy Comans, Michelle Hogan, Tessa Caporale, Susan Edwards, Lyntara Quirke, Allan Patching, J Simon Bell
BACKGROUND: Complex medication regimens are highly prevalent in residential aged care facilities (RACFs). Strategies to reduce unnecessary complexity may be valuable because complex medication regimens can be burdensome for residents and are costly in terms of nursing time. The aim of this study is to investigate application of a structured process to simplify medication administration in RACFs. METHODS: SImplification of Medications Prescribed to Long-tErm care Residents (SIMPLER) is a non-blinded, matched-pair, cluster randomised controlled trial of a single multidisciplinary intervention to simplify medication regimens...
January 12, 2018: Trials
https://www.readbyqxmd.com/read/29329527/emotional-and-cognitive-experiences-during-the-time-of-diagnosis-and-decision-making-following-a-prenatal-diagnosis-a-qualitative-study-of-males-presented-with-congenital-heart-defect-in-the-fetus-carried-by-their-pregnant-partner
#7
Tommy Carlsson, Elisabet Mattsson
BACKGROUND: Expectant fathers consider the second-trimester obstetric ultrasound examination as an important step towards parenthood, but are ill prepared for a detection of a fetal anomaly. Inductive research is scarce concerning their experiences and needs for support. Consequently, the aim of this study was to explore the emotional and cognitive experiences, during the time of diagnosis and decision-making, among males presented with congenital heart defect in the fetus carried by their pregnant partner...
January 12, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29329510/the-predictive-value-of-hunger-score-on-gastric-evacuation-after-oral-intake-of-carbohydrate-solution
#8
Qiu Weiji, Li Shitong, Luo Yu, Hua Tianfang, Kong Ning, Zhang Lina
BACKGROUND: Surgical patients are asked to fast for a sufficient duration to ensure that the amount of residual liquid in the stomach is within the safe range, thereby reducing the risk of gastric reflux perioperatively. The authors hypothesized that subjective hunger numerical rating scale (NRS) score could also help assess the process of gastric emptying and determine the amount of fluid remaining in the stomach. METHODS: The current study consisted of healthy volunteers recruited by advertisement and mutual introduction...
January 12, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29329336/effective-dispersal-and-density-dependence-in-mesophotic-macroalgal-forests-insights-from-the-mediterranean-species-cystoseira-zosteroides
#9
Pol Capdevila, Cristina Linares, Eneko Aspillaga, Joan Lluís Riera, Bernat Hereu
Dispersal and recruitment are fundamental processes for population recovery following disturbances in sessile species. While both processes are well understood for many terrestrial species, they still remain poorly resolved for some macroalgal species. Here we experimentally investigated the effective dispersal and recruit survival of a mesophotic Mediterranean fucoid, Cystoseira zosteroides. In three isolated populations, four sets of settlement collectors were placed at increasing distances (from 0 to 10 m) and different orientations (North, South, East and West)...
2018: PloS One
https://www.readbyqxmd.com/read/29327604/strategies-to-improve-recruitment-of-people-with-dementia-to-research-studies
#10
Ruth Bartlett, Richard Milne, Rebecca Croucher
Background Low participation in research is one of the key challenges to advancing understanding of dementia, and improving the care and treatment of those who live with this condition. Nurses and nurse researchers play a vital role in recruiting people with dementia to studies, as several countries including the United States and the United Kingdom set national targets and develop initiatives to encourage more people with dementia to take part in research. Aim To highlight the challenges to recruiting people with dementia to studies, and to identify strategies that nurses, and in particular, nurse researchers can use for overcoming them...
January 1, 2018: Dementia
https://www.readbyqxmd.com/read/29325809/spanish-validation-of-the-exercise-therapy-burden-questionnaire-etbq-for-the-assessment-of-barriers-associated-to-doing-physical-therapy-for-the-treatment-of-chronic-illness
#11
César Navarro-Albarracín, Serge Poiraudeau, Noelia Chico-Matallana, Jesús Vergara-Martín, William Martin, Adelaida María Castro-Sánchez, Guillermo A Matarán-Peñarrocha
BACKGROUND AND OBJETIVE: To validate the Spanish version of the Exercise Therapy Burden Questionnaire (ETBQ) for the assessment of barriers associated to doing physical therapy for the treatment of chronic ailments. PATIENTES AND METHODS: A sample of 177 patients, 55.93% men and 44.07% women, with an average age of 51.03±14.91 was recruited. The reliability of the questionnaire was tested with Cronbach's alpha coefficient, and the validity of the instrument was assessed through the divergent validation process and factor analysis...
January 8, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29325593/evaluating-the-long-term-impact-of-the-fostering-changes-training-programme-for-foster-carers-in-wales-the-confidence-in-care-trial-study-protocol-for-a-randomised-controlled-trial
#12
Gwenllian Moody, Lucy Brookes-Howell, Rebecca Cannings-John, Sue Channon, Elinor Coulman, Mandy Lau, Alyson Rees, Jonathan Scourfield, Jeremy Segrott, Michael Robling
BACKGROUND: The Fostering Changes programme was developed by the Adoption and Fostering National Team at the Maudsley Hospital, South London, in conjunction with King's College London. It is a 12-week group-based training programme for foster and kin carers, which aims to build positive relationships between carers and children, encourage positive child behaviour and set appropriate limits, through a practical skills-based approach. The programme also aims to improve foster carers' understanding of the causes of children's social and emotional difficulties and their confidence in applying this knowledge in various situations...
January 11, 2018: Trials
https://www.readbyqxmd.com/read/29324827/psychometric-properties-of-the-arabic-version-of-the-12-item-diabetes-fatalism-scale
#13
Ola Sukkarieh-Haraty, Leonard E Egede, Joelle Abi Kharma, Maya Bassil
BACKGROUND: There are widespread fatalistic beliefs in Arab countries, especially among individuals with diabetes. However, there is no tool to assess diabetes fatalism in this population. This study describes the processes used to create an Arabic version of the Diabetes Fatalism Scale (DFS) and examine its psychometric properties. METHODS: A descriptive correlational design was used with a convenience sample of Lebanese adults (N = 274) with type 2 diabetes recruited from a major hospital in Beirut, Lebanon and by snowball sampling...
2018: PloS One
https://www.readbyqxmd.com/read/29323799/knowledge-perception-and-utilization-of-standardized-nursing-language-snl-nnn-among-nurses-in-three-selected-hospitals-in-ondo-state-nigeria
#14
Matthew Idowu Olatubi, Olufemi Oyebanji Oyediran, Funmilola Adenike Faremi, Omowumi Romoke Salau
The use of standardized nursing languages helps nurses understand patients' needs with precision and speed. This study assessed the knowledge of standardized nursing languages (SNL); how nurses perceive SNL and nurses utilization of SNL. The study adopted a cross sectional research design. Participants were recruited using convenience sampling technique. Data was collected using 5-sectioned self-structured questionnaires whose validity and reliability had been previously ascertained. Data collected was analyzed using Statistical Package for Social Sciences (SPSS) version 20...
January 11, 2018: International Journal of Nursing Knowledge
https://www.readbyqxmd.com/read/29323797/relations-between-cortical-thickness-serotonin-1a-receptor-binding-and-structural-connectivity-a-multimodal-imaging-study
#15
Rajapillai L I Pillai, Ashwin Malhotra, Deborah D Rupert, Bennett Weschler, John C Williams, Mengru Zhang, Jie Yang, J John Mann, Maria A Oquendo, Ramin V Parsey, Christine DeLorenzo
Serotonin 1A (5-HT1A ) receptors play a direct role in neuronal development, cell proliferation, and dendritic branching. We hypothesized that variability in 5-HT1A binding can affect cortical thickness, and may account for a subtype of major depressive disorder (MDD) in which both are altered. To evaluate this, we measured cortical thickness from structural magnetic resonance imaging (MRI) and 5-HT1A binding by positron emission tomography (PET) in an exploratory study. To examine a range of 5-HT1A binding and cortical thickness values, we recruited 25 healthy controls and 19 patients with MDD...
February 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29322409/tracking-competent-host-defence-to-chronic-inflammation-an-in-vivo-model-of-peritonitis
#16
Javier Uceda Fernandez, David Millrine, Simon A Jones
Anti-microbial host defence is dependent on the rapid recruitment of inflammatory cells to the site of infection, the elimination of invading pathogens, and the efficient resolution of inflammation so as to minimise damage to the host. The peritoneal cavity provides an easily accessible and physiologically relevant system where the delicate balance of these processes may be studied. Here, we describe murine models of peritoneal inflammation that enable studies of both competent anti-microbial immunity and inflammation associated tissue damage as a consequence of recurrent bacterial challenge...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29321971/processing-and-regulation-of-negative-emotions-in-anorexia-nervosa-an-fmri-study
#17
Maria Seidel, Joseph A King, Franziska Ritschel, Ilka Boehm, Daniel Geisler, Fabio Bernardoni, Matthias Beck, Sophie Pauligk, Ronald Biemann, Alexander Strobel, Thomas Goschke, Henrik Walter, Veit Roessner, Stefan Ehrlich
Theoretical models and recent advances in the treatment of anorexia nervosa (AN) have increasingly focused on the role of alterations in the processing and regulation of emotions. To date, however, our understanding of these changes is still limited and reports of emotional dysregulation in AN have been based largely on self-report data, and there is a relative lack of objective experimental evidence or neurobiological data. The current functional magnetic resonance imaging (fMRI) study investigated the hemodynamic correlates of passive viewing and voluntary downregulation of negative emotions by means of the reappraisal strategy detachment in AN patients...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29321955/the-central-domain-of-unc-45-chaperone-inhibits-the-myosin-power-stroke
#18
Paul J Bujalowski, Paul Nicholls, Eleno Garza, Andres F Oberhauser
The multidomain UNC-45B chaperone is crucial for the proper folding and function of sarcomeric myosin. We recently found that UNC-45B inhibits the translocation of actin by myosin. The main functions of the UCS and TPR domains are known but the role of the central domain remains obscure. Here, we show-using in vitro myosin motility and ATPase assays-that the central domain alone acts as an inhibitor of the myosin power stroke through a mechanism that allows ATP turnover. Hence, UNC-45B is a unique chaperone in which the TPR domain recruits Hsp90; the UCS domain possesses chaperone-like activities; and the central domain interacts with myosin and inhibits the actin translocation function of myosin...
January 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29321502/the-peroxisomal-aaa-atpase-pex1-pex6-unfolds-substrates-by-processive-threading
#19
Brooke M Gardner, Dominic T Castanzo, Saikat Chowdhury, Goran Stjepanovic, Matthew S Stefely, James H Hurley, Gabriel C Lander, Andreas Martin
Pex1 and Pex6 form a heterohexameric motor essential for peroxisome biogenesis and function, and mutations in these AAA-ATPases cause most peroxisome-biogenesis disorders in humans. The tail-anchored protein Pex15 recruits Pex1/Pex6 to the peroxisomal membrane, where it performs an unknown function required for matrix-protein import. Here we determine that Pex1/Pex6 from S. cerevisiae is a protein translocase that unfolds Pex15 in a pore-loop-dependent and ATP-hydrolysis-dependent manner. Our structural studies of Pex15 in isolation and in complex with Pex1/Pex6 illustrate that Pex15 binds the N-terminal domains of Pex6, before its C-terminal disordered region engages with the pore loops of the motor, which then processively threads Pex15 through the central pore...
January 10, 2018: Nature Communications
https://www.readbyqxmd.com/read/29321374/selective-cd28-blockade-attenuates-ctla-4-dependent-cd8-memory-t-cell-effector-function-and-prolongs-graft-survival
#20
Danya Liu, I Raul Badell, Mandy L Ford
Memory T cells pose a significant problem to successful therapeutic control of unwanted immune responses during autoimmunity and transplantation, as they are differentially controlled by cosignaling receptors such as CD28 and CTLA-4. Treatment with abatacept and belatacept impede CD28 signaling by binding to CD80 and CD86, but they also have the unintended consequence of blocking the ligands for CTLA-4, a process that may inadvertently boost effector responses. Here, we show that a potentially novel anti-CD28 domain antibody (dAb) that selectively blocks CD28 but preserves CTLA-4 coinhibition confers improved allograft survival in sensitized recipients as compared with CTLA-4 Ig...
January 11, 2018: JCI Insight
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