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https://www.readbyqxmd.com/read/29793120/socioeconomic-status-of-parents-with-children-participating-on-youth-club-sport-teams
#1
Eric G Post, Nicole E Green, Daniel A Schaefer, Stephanie M Trigsted, M Alison Brooks, Timothy A McGuine, Andrew M Watson, David R Bell
OBJECTIVES: To describe the socioeconomic status, measured by household income and educational attainment, of parents with children participating on youth club sport teams. DESIGN: Cross-sectional survey. SETTING: Local sport events. PARTICIPANTS: 949 parents (571 female) of youth athletes between 10 and 18 years old were recruited at club team events and practices to complete an anonymous questionnaire. MAIN OUTCOME MEASURES: SES variables included total household income (THI) and educational attainment...
May 17, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29793101/-survey-of-wellbeing-of-young-children-swyc-how-does-it-fit-for-screening-developmental-delay-in-brazilian-children-aged-4-to-58-months
#2
R S Moreira, L C Magalhães, C M Siqueira, C R L Alves
OBJECTIVE: To replicate the original normative study of the SWYC's Milestones Questionnaires for children in Brazil. Our goals were to compare the performance of Brazilian and North American children using this screening tool and to verify the reliability and validity of the Brazilian version. STUDY DESIGN AND SETTING: Cross-sectional study with children aged 1-65 months and their guardians, recruited in southern Brazil. Parents were interviewed using the Developmental Milestones questionnaire, which contains 10 questions about cognitive, motor, social, and language abilities...
May 21, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29793085/socio-demographic-factors-associated-with-choosing-violent-methods-of-suicide-2011-2016-ilam-province
#3
Yousef Veisani, Fathola Mohamadian, Ali Delpisheh, Salman Khazaei
BACKGROUND: In new strategies towards of suicide prevention the best approach currently is based on specific method had specific risk factors. Therefore in this study we aimed to find out the association between socio-demographic factors and methods in completed suicide, 2011-2016, Ilam province. METHODS: A cross-sectional study, 2011-2016, was conducted. A total of 540 completed suicides were recruited to the study. Data were collected by systematic registration suicide data (SRSD) and Legal Medicine Organization (LMO)...
May 21, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29793084/subthreshold-depression-among-diabetes-patients-in-beijing-cross-sectional-associations-among-sociodemographic-clinical-and-behavior-factors
#4
Dandan Wang, Lintao Shi, Leling Li, Xiaohui Guo, Yufeng Li, Yuan Xu, Shinan Yin, Qiaozhen Wu, Yu Yang, Xiaoming Zhuang, Yingli Gai, Quanmin Li, Yanjun Liu
BACKGROUND: This study explores the prevalence of subthreshold depression (SubD) and its association with factors in type 2 diabetes mellitus (T2DM) patients. METHODS: This cross-sectional study involved 808 outpatients with T2DM from ten hospitals in Beijing between September 2015 and January 2016. All participants completed the Patient Health Questionnaire 9-item (PHQ-9) to evaluate depressive status, with scores between 5 and 14 considered SubD. Conditional logistic regression was conducted to investigate the variables associated with SubD in T2DM patients...
May 18, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29793020/epha2-stimulates-vcam-1-expression-through-calcium-dependent-nfat1-activity
#5
Steven Daniel Funk, Alexandra C Finney, Arif Yurdagul, Christopher B Pattillo, A Wayne Orr
Endothelial cell activation by proinflammatory stimuli drives leukocyte recruitment through enhanced expression of counter-receptors such as vascular cell adhesion molecule-1 (VCAM-1). We previously demonstrated that activation of the receptor tyrosine kinase EphA2 with its ligand ephrin-A1 induces VCAM-1 expression. Here, we sought to characterize the proinflammatory signaling pathways involved. Analysis of over-represented transcription factors in ephrin-A1-induced genes identified multiple potential transcriptional regulators, including the Rel family members nuclear factor-κB (NF-κB/p65) and nuclear factor of activated T-cells (NFAT)...
May 21, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29792999/does-solid-fusion-eliminate-rod-fracture-after-pedicle-subtraction-osteotomy-in-ankylosing-spondylitis-related-thoracolumbar-kyphosis
#6
Shi-Zhou Zhao, Bang-Ping Qian, Mu Qiao, Jun Jiang, Yong Qiu
BACKGROUND CONTEXT: Rod fracture (RF) has a negative impact on the surgical outcome of ankylosing spondylitis (AS) patients following lumbar pedicle subtraction osteotomy (PSO). However, there is a paucity of published studies analyzing the risk factors for RF in PSO-treated AS patients with thoracolumbar kyphosis. PURPOSE: To investigate the risk factors for RF after PSO for thoracolumbar kyphosis secondary to AS. STUDY DESIGN/SETTING: Retrospective single-center study...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792934/pretarsal-skin-height-changes-in-children-receiving-topical-prostaglandin-analogue-therapy-for-primary-congenital-glaucoma
#7
Mohammed Al-Zobidi, Rajiv Khandekar, Augusto Cruz, Randy E Craven, Ches Souru, Rizwan Malik, Deepak P Edward
PURPOSE: To compare pretarsal skin height (PTSH), as proxy indicator of deepening of the upper eyelid sulcus, in children with primary congenital glaucoma (PCG) treated with topical prostaglandin analogues (PGAs) with PTSH in healthy children (control group 1) and children with PCG but not using PGAs (control group 2). METHODS: We recruited children with PCG who had been using PGAs for at least 6 months (PCG/PGA group). PTSH in all participants was measured using ImageJ software from photographs taken in a standardized manner...
May 21, 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29792694/biomimetic-artificial-epigenetic-code-for-targeted-acetylation-of-histones
#8
Junichi Taniguchi, Yihong Feng, Ganesh N Pandian, Fumitaka Hashiya, Takuya Hidaka, Kaori Hashiya, Soyoung Park, Toshikazu Bando, Shinji Ito, Hiroshi Sugiyama
While the central role of locus-specific acetylation of histone proteins in eukaryotic gene expression is well established, the availability of designer tools to regulate acetylation at particular nucleosome sites remains limited. Here, we develop a unique strategy to introduce acetylation by constructing a bifunctional molecule designated Bi-PIP. Bi-PIP has a P300/CBP-selective bromodomain inhibitor (Bi) as a P300/CBP recruiter and a pyrrole-imidazole polyamide (PIP) as a sequence-selective DNA binder. Biochemical assays verified that Bi-PIPs recruit P300 to the nucleosomes having their target DNA sequences and extensively accelerate acetylation...
May 24, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29792692/small-molecule-targeted-recruitment-of-a-nuclease-to-rna
#9
Matthew G Costales, Yasumasa Matsumoto, Sai Pradeep Velagapudi, Matthew D Disney
The choreography between RNA synthesis and degradation is a key determinant in biology. Engineered systems such as CRISPR have been developed to rid a cell of RNAs. Here, we show that a small molecule can recruit a nuclease to a specific transcript, triggering its destruction. A small molecule that selectively binds the oncogenic microRNA(miR)-96 hairpin precursor was appended with a short 2'-5' poly(A) oligonucleotide. The conjugate locally activated endogenous, latent ribonuclease (RNase L), which selectively cleaved the miR-96 precursor in cancer cells in a catalytic and sub-stoichiometric fashion...
May 24, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29792687/co-mobility-of-gabarap-and-phosphatidylinositol-4-kinase-2a-on-cytoplasmic-vesicles
#10
Yan Chen, Hui-Qiao Sun, John P Eichorst, Joseph P Albanesi, Helen Yin, Joachim D Mueller
We previously reported that recruitment of the Type IIA phosphatidylinositol 4-kinase (PI4K2A) to autophagosomes by GABARAP, a member of the Atg8 family of autophagy-related proteins, is important for autophagosome-lysosome fusion. Because both PI4K2A and GABARAP have also been implicated in the intracellular trafficking of plasma membrane receptors in the secretory/endocytic pathway, we characterized their interaction in cells under non-autophagic conditions. Fluorescence fluctuation spectroscopy measurements revealed that GABARAP exists predominantly as a cytosolic monomer in live cells, but is recruited to small cytoplasmic vesicles upon overexpression of PI4K2A...
May 24, 2018: Biochemistry
https://www.readbyqxmd.com/read/29792670/biomarker-based-metabolic-labeling-for-redirected-and-enhanced-immune-response
#11
Shanshan Li, Bingchen Yu, Jiajia Wang, Yueqin Zheng, Huajie Zhang, Margaret J Walker, Zhengnan Yuan, He Zhu, Jun Zhang, Peng George Wang, Binghe Wang
Installation of an antibody-recruiting moiety on the surface of disease-relevant cells can lead to the selective destruction of targets by the immune system. Such an approach can be an alternative strategy to traditional chemotherapeutics in cancer therapy and possibly other diseases. Herein we describe the development of a new strategy to selectively label targets with an antibody-recruiting moiety through its covalent and stable installation, complementing existing methods of employing reversible binding...
May 24, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29792595/brg1-governs-glucocorticoid-receptor-interactions-with-chromatin-and-pioneer-factors-across-the-genome
#12
Jackson A Hoffman, Kevin W Trotter, James M Ward, Trevor K Archer
The Glucocorticoid Receptor (GR) alters transcriptional activity in response to hormones by interacting with chromatin at GR binding sites (GBSs) throughout the genome. Our work in human breast cancer cells identifies three classes of GBSs with distinct epigenetic characteristics and reveals that BRG1 interacts with GBSs prior to hormone exposure. The GBSs pre-occupied by BRG1 are more accessible and transcriptionally active than other GBSs. BRG1 is required for a proper and robust transcriptional hormone response and knockdown of BRG1 blocks recruitment of the pioneer factors FOXA1 and GATA3 to GBSs...
May 24, 2018: ELife
https://www.readbyqxmd.com/read/29792485/telephone-assisted-parent-mediated-cbt-for-rural-latino-youth-with-anxiety-a-feasibility-trial
#13
Denise A Chavira, Cristina Bustos, Maritza Garcia, Francisco Reinosa Segovia, Afshan Baig, Bernardo Ng, Alvaro Camacho
OBJECTIVE: In this study, we tailor a child anxiety cognitive-behavior therapy (CBT) program to fit the needs of rural Latino/a Spanish-speaking families and examine the feasibility, acceptability, tolerability, and safety of this intervention using 2 modes of service delivery. METHOD: Children (n = 31; age 8-13) with anxiety disorders were recruited from primary care settings and randomized to 1 of 2 modes of parent-mediated CBT bibliotherapy: (1) telephone-delivered, therapist-assisted bibliotherapy (TTB; n = 15), and (2) a more minimal contact, self-directed, bibliotherapy condition (SB; n = 16)...
May 24, 2018: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/29792481/risk-and-protective-factors-of-intimate-partner-violence-among-south-asian-immigrant-women-and-perceived-need-for-services
#14
Bushra Sabri, Michelle Simonet, Jacquelyn C Campbell
OBJECTIVES: Limited research exists on multilevel influences of intimate partner violence (IPV) among immigrant groups in the United States, particularly South Asians. Using a socioecological framework, this study examined risk and protective factors of IPV among a diverse group of South Asian immigrant survivors of IPV and identified their perceived need for services. METHOD: Sixteen South Asian immigrant survivors were recruited from New York; Maryland; Virginia; and Washington, DC, using a snowball sampling method...
May 24, 2018: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/29792448/the-experimental-evidence-for-parapsychological-phenomena-a-review
#15
Etzel Cardeña
This article presents a comprehensive integration of current experimental evidence and theories about so-called parapsychological (psi) phenomena. Throughout history, people have reported events that seem to violate the common sense view of space and time. Some psychologists have been at the forefront of investigating these phenomena with sophisticated research protocols and theory, while others have devoted much of their careers to criticizing the field. Both stances can be explained by psychologists' expertise on relevant processes such as perception, memory, belief, and conscious and nonconscious processes...
May 24, 2018: American Psychologist
https://www.readbyqxmd.com/read/29792293/recruitment-and-participation-of-recreational-runners-in-a-large-epidemiological-and-genetic-research-study-retrospective-data-analysis
#16
Silvia Manzanero, Maria Kozlovskaia, Nicole Vlahovich, David C Hughes
BACKGROUND: With the increasing capacity for remote collection of both data and samples for medical research, a thorough assessment is needed to determine the association of population characteristics and recruitment methodologies with response rates. OBJECTIVE: The aim of this research was to assess population representativeness in a two-stage study of health and injury in recreational runners, which consisted of an epidemiological arm and genetic analysis. METHODS: The cost and success of various classical and internet-based methods were analyzed, and demographic representativeness was assessed for recruitment to the epidemiological survey, reported willingness to participate in the genetic arm of the study, actual participation, sample return, and approval for biobank storage...
May 23, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29792233/antibiotic-resistance-and-molecular-characterization-of-diarrheagenic-escherichia-coli-and-non-typhoidal-salmonella-strains-isolated-from-infections-in-southwest-china
#17
Shun-Xian Zhang, Yong-Ming Zhou, Li-Guang Tian, Jia-Xu Chen, Rita Tinoco-Torres, Emmanuel Serrano, Shi-Zhu Li, Shao-Hong Chen, Lin Ai, Jun-Hu Chen, Shang Xia, Yan Lu, Shan Lv, Xue-Jiao Teng, Wen Xu, Wen-Peng Gu, Si-Tang Gong, Xiao-Nong Zhou, Lan-Lan Geng, Wei Hu
BACKGROUND: Bacterial diarrhea is one of the most common causes for medical consultations, mortality and morbidity in the world. Diarrheagenic Escherichia coli (DEC) and non-typhoidal Salmonella (NTS) are major intestinal pathogens in developing countries, and the indiscriminate use of antibiotics has greatly contributed to resistant strains. Hence, the aim of the present study is to identify the antimicrobial resistance patterns and the molecular characteristics of DEC and NTS in southwest, China...
May 7, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29792213/rate-of-presence-of-11-thoracic-vertebrae-and-6-lumbar-vertebrae-in-asymptomatic-chinese-adult-volunteers
#18
Ying-Zhao Yan, Qing-Ping Li, Cong-Cong Wu, Xiang-Xiang Pan, Zhen-Xuan Shao, Shao-Qing Chen, Ke Wang, Xi-Bang Chen, Xiang-Yang Wang
BACKGROUND: An increasing number of studies on spinal morphology in asymptomatic Asian and Western patients have been reported. Variation in spinal anatomy among patients is considered as the cause of wrong-level surgery in up to 40% of cases. The present study examined the rate of presence of 11 thoracic vertebrae and 6 lumbar vertebrae in 293 asymptomatic Chinese adult volunteers. METHODS: From May 27, 2016, to November 11, 2017, a cohort of 325 asymptomatic Chinese adults meeting the study exclusion criteria was recruited...
May 23, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29792210/quantitative-cardiovascular-magnetic-resonance-extracellular-volume-native-t1-and-18f-fdg-pet-cmr-imaging-in-patients-after-revascularized-myocardial-infarction-and-association-with-markers-of-myocardial-damage-and-systemic-inflammation
#19
Karl P Kunze, Ralf J Dirschinger, Hans Kossmann, Franziska Hanus, Tareq Ibrahim, Karl-Ludwig Laugwitz, Markus Schwaiger, Christoph Rischpler, Stephan G Nekolla
BACKGROUND: Characterization of tissue integrity and inflammatory processes after acute myocardial infarction (AMI) using non-invasive imaging is predictive of patient outcome. Quantitative cardiovascular magnetic resonance (CMR) techniques such as native T1 and extracellular volume (ECV) mapping as well as 18 F-FDG positron emission tomography (PET) imaging targeting inflammatory cell populations are gaining acceptance, but are often applied without assessing their quantitative potential...
May 24, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29792188/health-related-quality-of-life-in-multiple-sclerosis-temperament-outweighs-edss
#20
S Salhofer-Polanyi, F Friedrich, S Löffler, P S Rommer, A Gleiss, R Engelmaier, F Leutmezer, B Vyssoki
BACKGROUND: The influence of personality on health-related quality of life in patients with multiple sclerosis has been the focus of previous studies showing that introversion and neuroticism were related with reduced health related quality of life. However, no data exist on the impact of temperament on quality of life in this patient group. METHODS: Between April 2014 and March 2016 139 multiple sclerosis patients were recruited from a specialized outpatient clinic of the general hospital of Vienna...
May 23, 2018: BMC Psychiatry
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