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https://www.readbyqxmd.com/read/28212579/suicidal-ideation-among-chinese-cancer-inpatients-of-general-hospitals-prevalence-and-correlates
#1
Bao-Liang Zhong, Si-Heng Li, Shu-Yan Lv, Shun-Li Tian, Zhi-Dong Liu, Xu-Bin Li, Hong-Qing Zhuang, Ran Tao, Wei Zhang, Chuan-Jun Zhuo
Cancer patients are at high risk for suicide, particularly when they are informed about the cancer diagnosis or hospitalized for cancer treatment. Therefore, oncology healthcare settings such as large general hospitals in China, may represent an ideal setting to identify and treat suicidality in cancer patients. However, the clinical epidemiology of suicidality of Chinese cancer patients remains largely unknown. This study examined the prevalence and correlates of suicidal ideation among Chinese cancer inpatients of large general hospitals...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212535/integration-of-the-cancer-related-inflammatory-response-as-a-stratifying-biomarker-of-survival-in-hepatocellular-carcinoma-treated-with-sorafenib
#2
Jessica Howell, David J Pinato, Ramya Ramaswami, Tadaaki Arizumi, Carlotta Ferrari, Antonello Gibbin, Michela E Burlone, Giulia Guaschino, Pierluigi Toniutto, James Black, Laura Sellers, Masatoshi Kudo, Mario Pirisi, Rohini Sharma
BACKGROUND AND AIMS: Response to sorafenib is highly variable in hepatocellular carcinoma (HCC). Baseline inflammatory parameters and treatment toxicities may improve survival prediction in patients on sorafenib therapy. RESULTS: 442 patients with advanced stage HCC on sorafenib were recruited (follow-up 5096 person-months at risk). 88% had BCLC stage B or greater HCC and 72.3% had Child-Pugh A cirrhosis. On Cox multivariate regression, previously-treated HCC (HR 0...
February 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212523/redox-regulation-in-metabolic-programming-and-inflammation
#3
REVIEW
Helen R Griffiths, Dan Gao, Chathyan Pararasa
Energy metabolism and redox state are intrinsically linked. In order to mount an adequate immune response, cells must have an adequate and rapidly available energy resource to migrate to the inflammatory site, to generate reactive oxygen species using NADPH as a cofactor and to engulf bacteria or damaged tissue. The first responder cells of the innate immune response, neutrophils, are largely dependent on glycolysis. Neutrophils are relatively short-lived, dying via apoptosis in the process of bacterial killing through production of hypochlorous acid and release of extracellular NETs...
February 12, 2017: Redox Biology
https://www.readbyqxmd.com/read/28212408/prevalence-and-associated-comorbidities-of-restless-legs-syndrome-rls-data-from-a-large-population-based-door-to-door-survey-on-19176-adults-in-tehran-iran
#4
Seyed-Mohammad Fereshtehnejad, Arash Rahmani, Mahdiyeh Shafieesabet, Mahshid Soori, Ahmad Delbari, Mohammad Reza Motamed, Johan Lökk
BACKGROUND: Discrepancies have been reported in the prevalence rate of restless legs syndrome (RLS) among different ethnic groups and geographic populations. Furthermore, there are disagreements on determinant factors and associated comorbidities of RLS. We aimed to estimate prevalence of RLS and investigate its associated comorbid conditions and risk factors in a large population-based door-to-door survey. METHODS: Following a multistage random sampling from the households lived in 22 urban districts of Tehran, Iran, 19176 participants with ≥30 years of age were recruited...
2017: PloS One
https://www.readbyqxmd.com/read/28212303/associations-of-overweight-obesity-and-related-factors-with-sleep-related-breathing-disorders-and-snoring-in-adolescents-a-cross-sectional-survey
#5
Yue Ma, Liping Peng, Changgui Kou, Shucheng Hua, Haibo Yuan
Background: Sleep-related breathing disorders (SRBD) have been identified as a major public health problem closely related to adolescent obesity. We aimed to estimate the prevalences of SRBD and snoring in adolescents in Changchun City, Northeastern China, and to evaluate the associated factors in this population. Methods: In total, 1955 adolescents aged 11-18 years were recruited in Changchun City using stratified cluster sampling. Parents and caretakers of children completed the questionnaires, which included demographic characteristics, anthropometric parameters and a pediatric sleep questionnaire (SRBD scale)...
February 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28212298/prevalence-and-clinical-impact-of-human-pegivirus-1-infection-in-hiv-1-infected-individuals-in-yunnan-china
#6
Zhijiang Miao, Li Gao, Yindi Song, Ming Yang, Mi Zhang, Jincheng Lou, Yue Zhao, Xicheng Wang, Yue Feng, Xingqi Dong, Xueshan Xia
Human Pegivirus-1 (HPgV-1) may have a beneficial impact on disease progression in human immunodeficiency virus-1 (HIV-1) infection. However, analysis of the genotypic diversity of HPgV-1 and its relevance to the progression of HIV-1 disease remains limited. A total of 1062 HIV-1-infected individuals were recruited in all sixteen prefectures of Yunnan province, China. The reverse transcription nested polymerase chain reaction (RT-nPCR), phylogenetic analyses, and clinical data analyses were used to detect HPgV-1 infection, determine genotype, and analyze HPgV-1 genotype impact on HIV-1 disease progression...
February 15, 2017: Viruses
https://www.readbyqxmd.com/read/28212252/health-literacy-in-orthopaedic-trauma-patients
#7
Filip Cosic, Lara Kimmel, Elton Edwards
OBJECTIVE: This study aimed to determine the level of health literacy in a postoperative orthopaedic trauma population and to evaluate the efficacy of a simple predischarge discussion strategy, targeted at improving health literacy. DESIGN: A pre-post intervention study was conducted from April 2014 to January 2015. SETTING: Academic Level 1 trauma center. PARTICIPANTS: One hundred ninety consecutive orthopaedic trauma patients with operatively managed lower limb fractures were recruited...
March 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28212204/1-2-4-dibromophenyl-3-6-6-trimethyl-1-5-6-7-tetrahydro-4h-indazol-4-one-a-novel-opioid-receptor-agonist-with-less-accompanying-gastrointestinal-dysfunction-than-morphine
#8
Po-Kuan Chao, Shau-Hua Ueng, Li-Chin Ou, Teng-Kuang Yeh, Wan-Ting Chang, Hsiao-Fu Chang, Shu-Chun Chen, Pao-Luh Tao, Ping-Yee Law, Horace H Loh, Ming-Fu Cheng, Jian-Ying Chuang, Chiung-Tong Chen, Chuan Shih, Shiu-Hwa Yeh
BACKGROUND: The authors investigated the pharmacology and signaling pathways of the opioid receptors modulated by compound 1, 1-(2,4-dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one. METHODS: In vitro studies of compound 1 were assessed by using a radioligand-binding assay (n = 3), a cyclic adenosine monophosphate assay (n = 3), a β-arrestin assay (n = 3), an internalization assay (n = 3), and an immunohistochemistry (n = 8). In vivo studies of compound 1 were characterized using a tail-flick test (n = 5 to 6), tail-clip test (n = 7), von Frey hair test (n = 5), and charcoal meal test (n = 5)...
February 17, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28212203/adding-examples-to-the-asa-physical-status-classification-improves-correct-assignment-to-patients
#9
Erin E Hurwitz, Michelle Simon, Sandhya R Vinta, Charles F Zehm, Sarah M Shabot, Abu Minhajuddin, Amr E Abouleish
BACKGROUND: Despite its widespread use, the American Society of Anesthesiologists (ASA)-Physical Status Classification System has been shown to result in inconsistent assignments among anesthesiologists. The ASA-Physical Status Classification System is also used by nonanesthesia-trained clinicians and others. In 2014, the ASA developed and approved examples to assist clinicians in determining the correct ASA-Physical Status Classification System assignment. The effect of these examples by anesthesia-trained and nonanesthesia-trained clinicians on appropriate ASA-Physical Status Classification System assignment in hypothetical cases was examined...
February 17, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28212195/suicide-in-guyana-nurses-perspectives
#10
Maureen Anthony, Carla Groh, Jean Gash
Guyana, an English-speaking country on the north coast of South America, has the highest suicide rate in the world. Nurses are an integral part of the healthcare team working with patients experiencing psychological distress and are uniquely qualified to add to the discourse on factors contributing to the high suicide rate in Guyana. The purpose of this study was to explore the attitudes and experiences of nurses and nurse assistants in Guyana related to suicide. Nine registered nurses and nurse assistants who worked at a private hospital in Georgetown, Guyana, were recruited to participate in a focus group...
January 2017: Journal of Forensic Nursing
https://www.readbyqxmd.com/read/28212136/impact-of-different-values-of-prosthesis-patient-mismatch-on-outcome-in-male-patients-with-aortic-valve-replacement
#11
Vito A Mannacio, Luigi Mannacio, Anita Antignano, Giovanni B Pinna, Raffaele Giordano, Michele Mottola, Gabriele Iannelli
AIMS: Mortality and left ventricular mass (LVM) recovery/regression after aortic valve replacement in patients with prosthesis-patient mismatch (PPM) is controversial. This study evaluated the impact of different values of indexed effective orifice area (EOAi) in male patients on mortality and indexed LVM (ILVM) recovery/regression. METHOD: The study recruited 376 male patients with and without PPM after aortic valve replacement with different EOAi cut-off values...
February 15, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28212131/psychometric-properties-of-a-new-instrument-for-assessing-irrational-thoughts-in-burn-victims-scale-of-irrational-thoughts-after-burn-injuries
#12
Zahra Zare, Homayoun Sadeghi-Bazargani, Fatemeh Ranjbar, Diana Stark Ekman, Mostafa Farahbakhsh, Hemmat Maghsoudi, Robert Ekman, Farideh Nasiri
The objective of this study was to develop and evaluate a scale for assessing irrational thoughts among burned patients. The present study was mixed (qualitative-methodologic) which was performed in several stages such as investigating similar or related scales, interviewing with patients and psychologists. Content validity was calculated by modified KAPPA basis on relevance and clarity. The reliability of the scale was measured using internal consistency and the test-retest method. To determine the construct validity, exploratory factor analysis approach using maximum likelihood extraction with varimax rotation was conducted...
February 9, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28212108/the-association-between-pre-pregnancy-obesity-and-screening-results-of-depression-for-all-trimesters-of-pregnancy-postpartum-and-1-year-after-birth-a-cohort-study
#13
Hanieh Salehi-Pourmehr, Sakineh Mohammad-Alizadeh, Nayyer Jafarilar-Agdam, Somayyeh Rafiee, Azizeh Farshbaf-Khalili
OBJECTIVE: To determine the relationship between pre-pregnancy obesity and screening results of gestational and post-delivery depression in women referred to the health centers of Tabriz, Iran. METHODS: In this cohort study, 62 and 245 pregnant women with class 2-3 obesity [body mass index (BMI)≥35 kg/m2] and normal-weight (BMI 18.5-24.9 kg/m2) were enrolled, respectively, in the first trimester of pregnancy from December 2012 to January 2016. For matching of groups, nulliparous and multiparous mothers aged 18-35 years were selected with the ratio of 1:4 in obese and normal BMI groups from the same recruitment center and to controlling the confounder factors, inclusion criteria were considered...
February 17, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28212050/volume-controlled-ventilation-does-not-prevent-injurious-inflation-during-spontaneous-effort
#14
Takeshi Yoshida, Susumu Nakahashi, Maria Aparecida Miyuki Nakamura, Yukiko Koyama, Rollin Roldan, Vinicius Torsani, Roberta R De Santis, Susimeire Gomes, Akinori Uchiyama, Marcelo B P Amato, Brian P Kavanagh, Yuji Fujino
RATIONALE: Spontaneous breathing during mechanical ventilation increases transpulmonary pressure and tidal volume, and worsens lung injury. Intuitively, controlling tidal volume and transpulmonary pressure might limit injury from added spontaneous effort. OBJECTIVES: To test the hypothesis that during spontaneous effort in injured lungs, tidal volume and transpulmonary pressure limitation by volume-controlled ventilation results in less injurious patterns of inflation...
February 17, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28211964/relationship-between-pathological-gambling-alexithymia-and-gambling-type
#15
Céline Bonnaire, Servane Barrault, Ania Aïte, Mathieu Cassotti, Sylvain Moutier, Isabelle Varescon
BACKGROUND AND OBJECTIVES: The aim of this study is to see if: (i) alexithymia is associated with PG and with the severity of gambling behavior; (ii) alexithymia is associated with strategic and non-strategic gambling. METHODS: Two hundred and twenty-six gamblers were recruited in different gambling locations. First, pathological gamblers (PGs) (n = 106) were compared to non-pathological gamblers (NPGs) (n = 120). Second, strategic gamblers (n = 92) were compared to non-strategic gamblers (n = 96)...
February 17, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28211882/aflibercept-as-a-second-line-therapy-for-neovascular-age-related-macular-degeneration-in-israel-asli-study
#16
L Tiosano, O Segal, N Mathalone, A Pollack, R Ehrlich, I Klemperer, Y Barak, I Moroz, I Chowers, M Goldstein
PurposeThe purpose of this study is to evaluate an early switch to aflibecept in eyes with neovascular age-related macular degeneration (nvAMD) showing partial or lack of response for initial therapy with bevacizumab.MethodsThe Aflibercept as a Second Line Therapy for Neovascular Age Related Macular Degeneration in Israel (ASLI) was a prospective, multicenter, single-arm clinical trial. Eyes with nvAMD having incomplete response to 3-9 prior bevacizumab injections were recruited. Three monthly intravitreal aflibercept (2 mg) injections were administered, followed by two bi-monthly injections and a final examination at week 28...
February 17, 2017: Eye
https://www.readbyqxmd.com/read/28211836/workplace-violence-and-the-meaning-of-work-in-healthcare-workers-a-phenomenological-study
#17
Josianne Lamothe, Stephane Guay
BACKGROUND: Workplace violence (WPV) has been associated with turnover intentions and reduced job satisfaction, yet the mechanisms behind such associations are still nebulous. Studying the way people make sense of their work in the context of WPV could lead to a better understanding of its consequences. PURPOSE: The objective of this exploratory study is to identify key features of meaning of work (MOW) in a group of healthcare workers and explain how these features can change following an act of WPV...
February 17, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28211835/how-many-days-are-required-for-workers-to%C3%A2-acclimatize-to-heat
#18
Tamer Mohamed Khalaf, Mohamed Zaki Ramadan, Riyad A Al-Ashaikh
BACKGROUND: Many research studies require recruiting heat-acclimatized workers to participate in heat-stress experiments and application fields. A reliable heat acclimatization program for workers in countries with hot environments has not been reported yet. OBJECTIVE: The objective of this study was to estimate the effects of heat stress and the amount of acclimatization required in hot-climate countries. METHODS: Eighteen male workers from an industrial population participated in this experiment...
February 17, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28211822/robot-assisted-end-effector-based-gait-training-in-chronic-stroke-patients-a%C3%A2-multicentric-uncontrolled-observational-retrospective-clinical-study
#19
Stefano Mazzoleni, Antonella Focacci, Marco Franceschini, Andreas Waldner, Chiara Spagnuolo, Elena Battini, Donatella Bonaiuti
BACKGROUND: Until now studies report inconclusive results as regards the effectiveness of exclusive use of robot-assisted training and clinical indications in stroke patients. OBJECTIVE: To evaluate if the only robot-assisted end-effector-based gait training can be feasible in chronic stroke subjects in terms of gait recovery. METHODS: Five rehabilitation centers participated and one hundred chronic post-stroke patients were recruited. Patients underwent a robot-assisted end-effector-based gait training as only rehabilitation treatment...
February 15, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28211791/motor-control-of-drosophila-feeding-behavior
#20
Olivia Schwarz, Ali Asgar Bohra, Xinyu Liu, Heinrich Reichert, Krishnaswamy VijayRaghavan, Jan Pielage
The precise coordination of body parts is essential for survival and behavior of higher organisms. While progress has been made towards the identification of central mechanisms coordinating limb movement, only limited knowledge exists regarding the generation and execution of sequential motor action patterns at the level of individual motoneurons. Here we use Drosophila proboscis extension as a model system for a reaching-like behavior. We first provide a neuroanatomical description of the motoneurons and muscles contributing to proboscis motion...
February 17, 2017: ELife
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