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https://www.readbyqxmd.com/read/29169124/dorsomedial-frontal-cortical-metabolic-differences-of-comorbid-generalized-anxiety-disorder-in-refractory-major-depression-a-18-f-fdg-pet-brain-imaging-study
#1
Chris Baeken, Guo-Rong Wu, Rudi De Raedt
BACKGROUND: Refractory major depressive disorder (MDD) is a severe mental disorder, chronic and difficult to treat. Although generalized anxiety disorder (GAD) is frequently observed as a comorbid diagnosis, little is known on the comorbid neurobiological substrate. Better insights may improve adequate treatment algorithms. OBJECTIVE: To examine this poorly understood clinical question, we recruited 52 individuals to participate in a [(18)F] FDG PET brain imaging study...
November 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29169121/perceptions-of-firearms-and-suicide-the-role-of-misinformation-in-storage-practices-and-openness-to-means-safety-measures
#2
Michael D Anestis, Sarah E Butterworth, Claire Houtsma
BACKGROUND: Firearm ownership and unsafe storage increase risk for suicide. Little is known regarding factors that influence storage practices and willingness to engage in means safety. METHODS: Utilizing Amazon's Mechanical Turk program, we recruited an online sample of 300 adults living in the US who own at least one firearm. Firearm storage practices and openness to means safety measures were assessed using items designed for this study. Data were collected and analyzed in 2017...
November 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29169075/maternal-intention-to-exclusively-breast-feed-among-mainland-chinese-mothers-a-cross-sectional-study
#3
Xiao Yang, Wan-Yim Ip, Ling-Ling Gao
OBJECTIVE: to examine postpartum maternal recall of their intentions to exclusively breast feed among breastfeeding women and identify its predictors. DESIGN AND SETTING: a cross-sectional descriptive study was conducted in a regional teaching hospital at Guangzhou, China between April 1 and July 14, 2014. PARTICIPANTS: 571 mothers who were within four days after delivery were recruited to the study. MEASUREMENTS: data were collected by four research assistants with maternal intention to breast feed data sheet, the Network Support for Breastfeeding Scale (NSBS), and a socio-demographic data sheet...
November 10, 2017: Midwifery
https://www.readbyqxmd.com/read/29169055/functional-electrical-stimulation-induced-muscular-fatigue-effect-of-fiber-composition-and-stimulation-frequency-on-rate-of-fatigue-development
#4
Maria Vromans, Pouran D Faghri
This investigation evaluated the progression towards fatigue in two muscles of differing fast- and slow-twitch fiber proportions (abductor pollicis brevis (APB) and vastus lateralis (VL)) when activated by functional electrical stimulation (FES) at three frequencies (10, 35, and 50 Hz). Fatigue was defined as a 50% drop from the initial FES-induced force of 25% maximal voluntary contraction (MVC). Ten healthy adults (mean age: 23.2 ± 3.0 years) were recruited; participants signed an IRB approved consent form prior to participation...
November 20, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29169002/skin-cancer-awareness-amongst-irish-golfers
#5
S McCarthy, L Paul, M O'Connell
Aim The aim of this study was to assess skin cancer awareness and identify the UV protective measures used by golfers within the Munster region of Ireland. Methods Subjects were recruited from throughout the Munster region at a regional competition, and at three other local golf clubs and "pro" shops. Participants filled out a short anonymous validated questionnaire when collecting their score cards7. Results One hundred and sixty-three golfers completed the questionnaire with a mean age of 65.6 years. 137 (84%) were male and 26 (16%) were female...
August 12, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29168999/investigating-the-perceived-benefits-barriers-and-beliefs-towards-physical-activity-in-pregnancy-among-women-with-gestational-diabetes-mellitus
#6
C Hurst, C Flannery, M Byrne, P M Kearney, F Dunne, M O'Riordan, J C Walsh
Gestational Diabetes Mellitus (GDM) is a growing concern and poses serious health risks to both mother and child1. The current study explores the psychological determinants of exercise behaviour in a sample of pregnant women with GDM. A cross-sectional survey design was employed to examine exercise behaviour, illness perceptions, perceived barriers and benefits, exercise beliefs, and exercise self-efficacy using validated questionnaires. A sample of 46 pregnant women was recruited from University College Hospital Galway, Letterkenny General Hospital, Cork University Hospital and Mayo General Hospital in Castlebar...
August 12, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29168957/the-effects-of-introducing-tabata-interval-training-and-stability-exercises-to-school-children-as-a-school-based-intervention-program
#7
Annika Ekström, Anna Hafsteinsson Östenberg, Glenn Björklund, Marie Alricsson
Background Physical activities during leisure time as well as school hours have changed over the past few years, with adolescents being less physically active and adopting a sedentary lifestyle. Objective The overall objective of this mixed-methods study was to evaluate the feasibility of introducing a 4-min Tabata interval training into a lower secondary school context. A further aim was to evaluate the possible effects on: coordination, balance, and strength. Methods The study was conducted as an intervention study with a mixed-method approach...
November 23, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29168955/adherence-to-a-mediterranean-dietary-pattern-and-overweight-and-obesity-among-female-adolescents-in-iran
#8
Fatemeh Sedaghat, Farah Naja, Mina Darand, Bita Beyzai, Bahram Rashidkhani
Background Given the high prevalence of overweight and obesity in Iran, identification of a healthy diet is essential. Objective This study aimed to assess the association between adherence to a Mediterranean diet and overweight and obesity in female adolescents. Methods Two hundred and eighty female adolescents from high schools in Tehran were recruited. General information, physical activity and food frequency questionnaires were completed. Adherence to the Mediterranean diet was evaluated using the Mediterranean Style Dietary Pattern Score (MSDPS)...
November 23, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29168945/analysis-of-the-experiences-of-nurses-who-return-to-nursing-after-cancer
#9
Karen-Leigh Edward, Jo-Ann Giandinoto, Judelle McFarland
BACKGROUND: understanding the impact of role ambiguity (both professional and patient) can be a factor in deepening the understanding of the ongoing personal, professional and organisational requirements of nurses who are cancer survivors. PURPOSE: the aim of this qualitative study was to elucidate an in-depth description of nurses' experiences of surviving cancer. METHOD: an exploratory qualitative research design was used (n=8), with participants recruited between September 2014 and December 2016...
November 23, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29168917/in-vivo-mr-imaging-of-glioma-recruitment-of-adoptive-t-cells-labeled-with-nagdf4-tat-nanoprobes
#10
Hua Zhang, Yue Wu, Jing Wang, Zhongmin Tang, Yan Ren, Dalong Ni, Hongbo Gao, Ruixue Song, Teng Jin, Qiao Li, Wenbo Bu, Zhenwei Yao
Adoptive T lymphocyte immunotherapy is one of the most promising methods to treat residual lesions after glioma surgery. However, the fate of the adoptively transferred T-cells in vivo is unclear, hampering the understanding of this emerging therapy. Thus, it is highly desirable to develop noninvasive and quantitative in vivo tracking of these T-cells to glioma for better identification of the migratory fate and to provide objective evaluation of outcomes of adoptive T-cell immunotherapy targeting glioma. In this work, ultrasmall T1 MR-based nanoprobes, NaGdF4 -TAT, as molecular probes with high longitudinal relaxivity (8...
November 23, 2017: Small
https://www.readbyqxmd.com/read/29168691/a-recombinant-bbsome-core-complex-and-how-it-interacts-with-ciliary-cargo
#11
Björn Udo Klink, Eldar Zent, Puneet Juneja, Anne Kuhlee, Stefan Raunser, Alfred Wittinghofer
Cilia are small, antenna-like structures on the surface of eukaryotic cells that harbor a unique set of sensory proteins, including GPCRs and other membrane proteins. The transport of these proteins involves the BBSome, an eight-membered protein complex that is recruited to ciliary membranes by the G-protein Arl6. BBSome malfunction leads to Bardet-Biedl syndrome, a ciliopathy with severe consequences. Short ciliary targeting sequences (CTS) have been identified that trigger the transport of ciliary proteins...
November 15, 2017: ELife
https://www.readbyqxmd.com/read/29168587/effect-of-secondary-penicillin-prophylaxis-on-valvular-changes-in-patients-with-rheumatic-heart-disease-in-far-north-queensland
#12
Shankar Haran, Natalie Crane, Saniya Kazi, Louise Axford-Haines, Andrew White
OBJECTIVE: To determine the effect of secondary penicillin prophylaxis (SPP) on echocardiographic diagnosed valvular changes in patients with rheumatic heart disease (RHD) or history of acute rheumatic fever (ARF) in the Townsville Health district. DESIGN: Patients with known ARF/RHD were identified from the North Queensland RHD register, serial echocardiogram results and number of SPP doses received in 2014 were collated. Descriptive statistics were utilised. SETTING: Townsville Hospital and outreach clinics within the Townsville Health catchment zone...
November 23, 2017: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/29168576/clinical-value-of-peripheral-blood-microrna-detection-in-evaluation-of-sox-regimen-as-neoadjuvant-chemotherapy-for-gastric-cancer
#13
Bibo Tan, Yong Li, Yan Di, Liqiao Fan, Qun Zhao, Qingwei Liu, Dong Wang, Nan Jia
BACKGROUND: Neoadjuvant chemotherapy has been widely applied in treating advanced gastric cancer (GC). However, little research has been conducted on evaluating the effect of neoadjuvant chemotherapy. Purpose of this study was to evaluate the effect of SOX regimen as neoadjuvant chemotherapy by detecting some microRNAs. METHODS: Total 120 GC patients who had received neoadjuvant chemotherapy (SOX regimen) were recruited with 100 healthy participants as control contemporarily...
November 23, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29168575/cuffed-vs-uncuffed-tracheal-tubes-in-children-a-randomised-controlled-trial-comparing-leak-tidal-volume-and-complications
#14
N A Chambers, A Ramgolam, D Sommerfield, G Zhang, T Ledowski, M Thurm, M Lethbridge, M Hegarty, B S von Ungern-Sternberg
Cuffed tracheal tubes are increasingly used in paediatric anaesthetic practice. This study compared tidal volume and leakage around cuffed and uncuffed tracheal tubes in children who required standardised mechanical ventilation of their lungs in the operating theatre. Children (0-16 years) undergoing elective surgery requiring tracheal intubation were randomly assigned to receive either a cuffed or an uncuffed tracheal tube. Assessments were made at five different time-points: during volume-controlled ventilation 6 ml...
November 23, 2017: Anaesthesia
https://www.readbyqxmd.com/read/29168557/probiotics-for-vulvovaginal-candidiasis-in-non-pregnant-women
#15
REVIEW
Huan Yu Xie, Dan Feng, Dong Mei Wei, Ling Mei, Hui Chen, Xun Wang, Fang Fang
BACKGROUND: Vulvovaginal candidiasis (VVC) is estimated to be the second most common form of infection after bacterial vaginosis. The ability of probiotics in maintaining and recovering the normal vaginal microbiota, and their potential ability to resist Candidas give rise to the concept of using probiotics for the treatment of VVC. OBJECTIVES: To assess the effectiveness and safety of probiotics for the treatment of vulvovaginal candidiasis in non-pregnant women...
November 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29168549/first-polish-analysis-of-the-treatment-of-advanced-heart-failure-in-children-with-the-use-of-berlinheart-excor-mechanical-circulatory-support
#16
Szymon Pawlak, Roman Przybylski, Janusz Skalski, Joanna Śliwka, Andrzej Kansy, Adam Grzybowski, Arkadiusz Wierzyk, Jacek Białkowski, Bohdan Maruszewski, Marian Zembala
BACKGROUND: The treatment of advanced heart failure in children and infants poses a serious management problem. Heart failure in that patient group is usually of congenital etiology. The treatment schedules for pediatric patients are in most cases adapted from the guidelines for treatment of adults. Up to 2009, the treatment of that extremely difficult group of patients was limited to pharmacological therapy and occasional heart transplantations. Constantly increasing problems with recruiting donors, especially for the pediatric group, contribute to the fact that mechanical support with the use of ventricular assist devices is for many children the only chance to survive the period of waiting for a heart donor...
November 23, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29168508/structural-basis-for-the-initiation-of-eukaryotic-transcription-coupled-dna-repair
#17
Jun Xu, Indrajit Lahiri, Wei Wang, Adam Wier, Michael A Cianfrocco, Jenny Chong, Alissa A Hare, Peter B Dervan, Frank DiMaio, Andres E Leschziner, Dong Wang
Eukaryotic transcription-coupled repair (TCR) is an important and well-conserved sub-pathway of nucleotide excision repair that preferentially removes DNA lesions from the template strand that block translocation of RNA polymerase II (Pol II). Cockayne syndrome group B (CSB, also known as ERCC6) protein in humans (or its yeast orthologues, Rad26 in Saccharomyces cerevisiae and Rhp26 in Schizosaccharomyces pombe) is among the first proteins to be recruited to the lesion-arrested Pol II during the initiation of eukaryotic TCR...
November 22, 2017: Nature
https://www.readbyqxmd.com/read/29168473/yangxin-tongmai-formula-ameliorates-impaired-glucose-tolerance-in-children-with-graves-disease-through-upregulation-of-the-insulin-receptor-levels
#18
Yan-Hong Luo, Min Zhu, Dong-Gang Wang, Yu-Sheng Yang, Tao Tan, Hua Zhu, Jian-Feng He
Graves' disease (GD) is the leading cause of hyperthyroidism, and the majority of GD patients eventually develop disorders of glucose handling, which further affects their quality of life. Yangxin Tongmai formula (YTF) is modified from a famous formula of traditional Chinese medicine for the treatment of cardiovascular diseases. In this study we investigated the potential effects of YTF in the treatment of pediatric GD patients with impaired glucose tolerance. Forty pediatric GD patients and 20 healthy children were recruited for this clinical study...
November 23, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29168463/a-preliminary-study-of-natural-history-of-mild-traumatic-brain-injury-by-using-multidimensional-approach
#19
Ashok Munivenkatappa, Bhagavatula Indira Devi, Dhaval P Shukla, Jamuna Rajeswaran
BACKGROUND & OBJECTIVES: Spectrum of post-traumatic symptoms is frequent among mild traumatic brain injury (mTBI) patients. They account for symptoms in 30-80 per cent of patients during 3-4 months and 20-30 per cent of patients six months post-injury. There are no studies from India in this area. The present longitudinal study was conducted to evaluate the natural recovery of post-traumatic symptoms in mTBI patients. METHODS: Twenty five mTBI patients presenting with initial Glasgow coma scale score of 15 were recruited initially 2-3 wk post-injury...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29168432/bayesian-latent-time-joint-mixed-effect-models-for-multicohort-longitudinal-data
#20
Dan Li, Samuel Iddi, Wesley K Thompson, Michael C Donohue
Characterization of long-term disease dynamics, from disease-free to end-stage, is integral to understanding the course of neurodegenerative diseases such as Parkinson's and Alzheimer's, and ultimately, how best to intervene. Natural history studies typically recruit multiple cohorts at different stages of disease and follow them longitudinally for a relatively short period of time. We propose a latent time joint mixed effects model to characterize long-term disease dynamics using this short-term data. Markov chain Monte Carlo methods are proposed for estimation, model selection, and inference...
January 1, 2017: Statistical Methods in Medical Research
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