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Alida Fe Talento, Katie Dunne, Niamh Murphy, Brian O'Connell, Grace Chan, Eimear Ann Joyce, Ferry Hagen, Jacques F Meis, Ruauri Fahy, Larry Bacon, Elisabeth Vandenberge, Thomas R Rogers
Influenza virus infection is now recognised as a risk factor for invasive pulmonary aspergillosis (IPA). Delays in diagnosis contribute to delayed commencement of antifungal therapy. Additionally, the emergence of resistance to first-line triazole antifungal agents puts emphasis on early detection to prevent adverse outcomes. We present 2 allogeneic stem cell transplant patients who developed IPA due to triazole-resistant Aspergillus fumigatus following influenza infection. We underline the challenges faced in the management of these cases, the importance of early diagnosis and need for surveillance given the emergence of triazole-resistance...
March 23, 2018: Mycoses
Barbara Małgorzata Kalenik, Anna Góra-Sochacka, Agnieszka Sirko
Defensins are a family of host defense peptides present in vertebrates, invertebrates and plants. They display broad antimicrobial activity and immunomodulatory functions. Herein, the natural anti-influenzal role of β-defensins, as well as their potential usage as anti-influenza vaccine adjuvants and therapeutic agents, is reviewed. This article summarizes previously published information on β-defensin modes of action, expression changes after influenza infection and vaccination, biotechnological usage and possible boosting of their production by dietary supplementation...
March 2, 2018: Virus Research
Jianping Dai, Liming Gu, Yun Su, Qianwen Wang, Ying Zhao, Xiaoxua Chen, Huixiong Deng, Weizhong Li, Gefei Wang, Kangsheng Li
Oxidative stress, Nrf2-HO-1 and TLR-MAPK/NF-κB signaling pathways have been proved to be involved in influenza A virus (IAV) replication and influenzal pneumonia. In the previous studies, we have performed several high-throughput drug screenings based on the TLR pathways. In the present study, through plaque inhibition test, luciferase reporter assay, TCID50 , qRT-PCR, western blotting, ELISA and siRNA assays, we investigated the effect and mechanism of action of curcumin against IAV infection in vitro and in vivo...
January 2018: International Immunopharmacology
Wouter J Meijer, Francisca H H Linn, Anne M J Wensing, Helen L Leavis, Debby van Riel, Corine H GeurtsvanKessel, Mike P Wattjes, Jean-Luc Murk
Background: Acute influenza-associated encephalopathy/encephalitis (IAE) in adults is a rare but well-known complication of influenza virus infection. The diagnosis is difficult to make due to the absence of distinctive clinical symptoms and validated diagnostic criteria. We present an illustrative case and a case review on acute IAE in adults. Methods: We performed a Medline search of the English literature using the terms influenz*, encephal* and adult, and constructed a database of detailed descriptions of patients with influenza virus infection with influenza-like symptoms at the onset of neurological symptoms...
December 2016: JMM Case Reports
Lindsey Pujanandez
No abstract text is available yet for this article.
March 24, 2017: Science
Wouter J Meijer, Aleid G A van Noortwijk, Hein W Bruinse, Annemarie M J Wensing
BACKGROUND: Influenza virus infection is very common and a significant cause of morbidity and mortality in specific populations like pregnant women. Following the 2009 pandemic, several reports on the effects of influenza virus infection on maternal health and pregnancy outcome have been published. Also the safety and efficacy of antiviral treatment and vaccination of pregnant women have been studied. In this review, we have analyzed and summarized these data. OBJECTIVE: To provide information on the influence of influenza virus infection during pregnancy on maternal health and pregnancy outcome and on the effect of treatment and vaccination...
August 2015: Acta Obstetricia et Gynecologica Scandinavica
C R Wells, C T Bauch
Personal experiences with past infection events, or perceived vaccine failures and complications, are known to drive vaccine uptake. We coupled a model of individual vaccinating decisions, influenced by these drivers, with a contact network model of influenza transmission dynamics. The impact of non-influenzal influenza-like illness (niILI) on decision-making was also incorporated: it was possible for individuals to mistake niILI for true influenza. Our objectives were to (1) evaluate the impact of personal experiences on vaccine coverage; (2) understand the impact of niILI on behaviour-incidence dynamics; (3) determine which factors influence vaccine coverage stability; and (4) determine whether vaccination strategies can become correlated on the network in the absence of social influence...
August 2012: Epidemics
I V Pogarskaia, N A Kontarov, N V Balaev, N V Iuminova
Using the method of self fluorescence quenching influence of phospholipids on conformational state of HA has been studied. Interactions of HA with model phospholipids membranes are accompanied by changes of structure-dynamic protein organization. This method could be used for controlling the structure organization of proteins after receiving by virus the influenzal virusomal vaccine.
March 2012: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
D Fenoglio, M R Zocchi, A Parodi, P Durando, G Gabutitp, R Gasparini, A Poggi
INTRODUCTION: We previously reported that in HIV-1 infected patients circulating Vdelta1 T lymphocytes (Vdelta1) increase and proliferate in vitro in response to Candida albicans (Ca). Herein, we analysed the effects of MF59 adjuvant on the Vdelta1 T cell responses to hemagglutinin (HA) and Ca in HIV-1 seropositive and seronegative adults after influenzal vaccine, to clarify th molecular mechanisms triggered in vivo by an adjuvanted vaccine against influenza virus. MATERIALS AND METHODS: 58 seropositive (HIV-1+) and 48 seronegative (HIV-1-) subjects received influenzal vaccines containing or not the MF59 adjuvant...
September 2011: Journal of Preventive Medicine and Hygiene
G Hadfield
No abstract text is available yet for this article.
February 1923: Journal of Neurology and Psychopathology
V Boganovitch
No abstract text is available yet for this article.
February 1930: Archives of Disease in Childhood
No abstract text is available yet for this article.
April 1946: Hahnemann Monthly
No abstract text is available yet for this article.
February 1946: Annales Paediatrici. International Review of Pediatrics
No abstract text is available yet for this article.
February 9, 1946: Journal of the American Medical Association
No abstract text is available yet for this article.
December 1945: Manitoba Medical Review
No abstract text is available yet for this article.
November 1945: Journal of Immunology: Official Journal of the American Association of Immunologists
No abstract text is available yet for this article.
August 1946: Proceedings of the Royal Society of Medicine
No abstract text is available yet for this article.
August 1946: Marquette Medical Review
No abstract text is available yet for this article.
July 1946: Memphis Medical Journal
No abstract text is available yet for this article.
July 1946: Journal of Pediatrics
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