keyword
https://read.qxmd.com/read/38519153/diagnosis-and-prognosis-of-abnormal-cardiac-scintigraphy-uptake-suggestive-of-cardiac-amyloidosis-using-artificial-intelligence-a-retrospective-international-multicentre-cross-tracer-development-and-validation-study
#21
JOURNAL ARTICLE
Clemens P Spielvogel, David Haberl, Katharina Mascherbauer, Jing Ning, Kilian Kluge, Tatjana Traub-Weidinger, Rhodri H Davies, Iain Pierce, Kush Patel, Thomas Nakuz, Adelina Göllner, Dominik Amereller, Maria Starace, Alice Monaci, Michael Weber, Xiang Li, Alexander R Haug, Raffaella Calabretta, Xiaowei Ma, Min Zhao, Julia Mascherbauer, Andreas Kammerlander, Christian Hengstenberg, Leon J Menezes, Roberto Sciagra, Thomas A Treibel, Marcus Hacker, Christian Nitsche
BACKGROUND: The diagnosis of cardiac amyloidosis can be established non-invasively by scintigraphy using bone-avid tracers, but visual assessment is subjective and can lead to misdiagnosis. We aimed to develop and validate an artificial intelligence (AI) system for standardised and reliable screening of cardiac amyloidosis-suggestive uptake and assess its prognostic value, using a multinational database of 99m Tc-scintigraphy data across multiple tracers and scanners. METHODS: In this retrospective, international, multicentre, cross-tracer development and validation study, 16 241 patients with 19 401 scans were included from nine centres: one hospital in Austria (consecutive recruitment Jan 4, 2010, to Aug 19, 2020), five hospital sites in London, UK (consecutive recruitment Oct 1, 2014, to Sept 29, 2022), two centres in China (selected scans from Jan 1, 2021, to Oct 31, 2022), and one centre in Italy (selected scans from Jan 1, 2011, to May 23, 2023)...
April 2024: The Lancet. Digital health
https://read.qxmd.com/read/38518259/recyclable-and-bio-degradable-polyesters-in-a-circular-plastics-economy
#22
REVIEW
Changxia Shi, Ethan C Quinn, Wilfred T Diment, Eugene Y-X Chen
Polyesters carrying polar main-chain ester linkages exhibit distinct material properties for diverse applications and thus play an important role in today's plastics economy. It is anticipated that they will play an even greater role in tomorrow's circular plastics economy that focuses on sustainability, thanks to the abundant availability of their biosourced building blocks and the presence of the main-chain ester bonds that can be chemically or biologically cleaved on demand by multiple methods and thus bring about more desired end-of-life plastic waste management options...
March 22, 2024: Chemical Reviews
https://read.qxmd.com/read/38517201/review-article-upper-gastrointestinal-bleeding-review-of-current-evidence-and-implications-for-management
#23
REVIEW
Dennis L Shung, Loren Laine
BACKGROUND: Acute upper gastrointestinal bleeding (UGIB) is a common emergency requiring hospital-based care. Advances in care across pre-endoscopic, endoscopic and post-endoscopic phases have led to improvements in clinical outcomes. AIMS: To provide a detailed, evidence-based update on major aspects of care across pre-endoscopic, endoscopic and post-endoscopic phases. METHODS: We performed a structured bibliographic database search for each topic...
March 22, 2024: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/38517127/preparation-of-a-long-lasting-tablet-of-spinosad-microspheres-and-its-residual-insecticidal-efficacy-against-the-yellow-fever-mosquito-aedes-aegypti-diptera-culicidae-larvae
#24
JOURNAL ARTICLE
Hongxiao Yu, Yunqi Li, Hong Wang, Lei Zhang, Penghui Suo, Tianyun Su, Qian Han
BACKGROUNDS: To provide a long-lasting formulation for spinosad (SP) targeting larval stages of Aedes aegypti (Linnaeus) and others alike, a SP tablet was developed based on microspheres, using polylactic acid as inside coating material. The microspheres were encapsulated using polyethylene glycol and 1-hexadecanol to form a sustained-release SP tablet. Micromorphology, active ingredient loading, structure identification, photolysis resistance, and biological activity were evaluated in this report...
March 22, 2024: Pest Management Science
https://read.qxmd.com/read/38516021/agramp-machine-learning-models-for-predicting-antimicrobial-peptides-against-phytopathogenic-bacteria
#25
JOURNAL ARTICLE
Jonathan Shao, Yan Zhao, Wei Wei, Iosif I Vaisman
INTRODUCTION: Antimicrobial peptides (AMPs) are promising alternatives to traditional antibiotics for combating plant pathogenic bacteria in agriculture and the environment. However, identifying potent AMPs through laborious experimental assays is resource-intensive and time-consuming. To address these limitations, this study presents a bioinformatics approach utilizing machine learning models for predicting and selecting AMPs active against plant pathogenic bacteria. METHODS: N-gram representations of peptide sequences with 3-letter and 9-letter reduced amino acid alphabets were used to capture the sequence patterns and motifs that contribute to the antimicrobial activity of AMPs...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38514912/a-novel-hybrid-bont-a-and-hyaluronic-acid-cannula-based-technique-for-eyelid-ptosis-and-periorbital-rejuvenation
#26
JOURNAL ARTICLE
Luis Alberto Parra Hernández, Andrea Marcela Parra Hernández, Desiree Castelanich, Daniella Shitara, Maricarmen Chacín
BACKGROUND: Eyelid ptosis is characterized by an inferior displacement of the upper eyelid when the eye assumes its primary position. Besides its aesthetic implications, ptosis can also adversely affect visual acuity. OBJECTIVE: This study aimed to evaluate the simultaneous administration of IncobotulinumtoxinA (IncoBonTA) and hyaluronic acid effect in eyelid ptosis and ocular rejuvenation. METHODS: A novel, non-surgical technique for eyelid ptosis management involving IncoBonTA and hyaluronic acid the co-administration within a single syringe, and applied using a cannula...
March 21, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38514633/comparative-analysis-of-soil-quality-and-enzymatic-activities-under-different-tillage-based-nutrient-management-practices-in-soybean-wheat-cropping-sequence-in-vertisols
#27
JOURNAL ARTICLE
Satya Narayan Meena, Shanti Kumar Sharma, Pratap Singh, Bharat Prakash Meena, Asha Ram, Roshan Lal Meena, Deepak Singh, Ram Bhawan Meena, Mahaveer Nogiya, Devendra Jain, Kuldeep Kumar
In the modern era, intensive agricultural practices such as agrochemicals are applied in excessive amounts to enhance agricultural production. However, imbalanced adoption of these chemicals has arisen in the dwindling of agriculture factor productivity and soil quality. To maintain soil fertility and production, these chemical fertilizers must be supplemented with organic inputs. Keeping this in the backdrop, a research trail was established during 2018-19 and 2019-20 years at Research Farm of Agriculture University, Kota, India...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38512427/polylactic-co-glycolic-acid-polymer-based-nano-encapsulation-using-recombinant-maltoporin-of-aeromonas-hydrophila-as-potential-vaccine-candidate
#28
JOURNAL ARTICLE
Mave Harshitha, Ruveena D'souza, Somanath Disha, Uchangi Satyaprasad Akshath, Saurabh Dubey, Hetron Mweemba Munang'andu, Anirban Chakraborty, Indrani Karunasagar, Biswajit Maiti
Aquaculture production has been incurring economic losses due to infectious diseases by opportunistic pathogens like Aeromonas hydrophila, a bacterial agent that commonly affects warm water aquacultured fish. Developing an effective vaccine with an appropriate delivery system can elicit an immune response that would be a useful disease management strategy through prevention. The most practical method of administration would be the oral delivery of vaccine developed through nano-biotechnology. In this study, the gene encoding an outer membrane protein, maltoporin, of A...
March 21, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38511791/comprehensive-prognostic-assessment-in-kidney-cancer-a-multidimensional-approach-analyzing-fufang-sanling-granules-genetic-variants-and-immune-infiltration
#29
JOURNAL ARTICLE
Junlan Zhu, Yun Ye, Xin Zhao, Meiling Wu, Xuyao Wang, Peng Shu, Jian Liu, Xingguo Zhang
This study delves into the potential therapeutic benefits of Fufang Sanling Granules for kidney cancer, focusing on their active components and the underlying mechanisms of their interaction with cancer-related targets. By constructing a drug-active component-target network based on eight herbs, key active compounds such as kaempferol, quercetin, and linolenic acid were identified, suggesting their pivotal roles in modulating immune responses and cellular signaling pathways relevant to cancer progression. The research further identified 51 central drug-disease genes through comprehensive bioinformatics analyses, implicating their involvement in crucial biological processes and pathways...
March 21, 2024: Environmental Toxicology
https://read.qxmd.com/read/38511652/sensitivity-of-plasmopara-viticola-to-selected-fungicide-groups-and-the-occurrence-of-the-g143a-mutant-in-australian-grapevine-isolates
#30
JOURNAL ARTICLE
Ismail Ismail, Andrew S Taylor, Steven Van Den Heuvel, Anthony Borneman, Mark R Sosnowski
BACKGROUND: Grapevine downy mildew, caused by Plasmopara viticola, is an economically important disease in Australia and worldwide. The application of fungicides is the main tool to control this disease. Frequent fungicide applications can lead to the selection of resistant P. viticola populations, which has negative impacts on the management of the disease. Identification of resistance and its prevalence is necessary to inform resistance management strategies. RESULTS: A total of 86 P...
March 21, 2024: Pest Management Science
https://read.qxmd.com/read/38511515/angiogenic-imbalance-in-pregnancies-with-preterm-prelabor-rupture-of-membranes-between-34-and-37%C3%A2-weeks-of-gestation
#31
JOURNAL ARTICLE
Marian Kacerovsky, Helena Hornychova, Sunil Jaiman, Ladislava Pavlikova, Magdalena Holeckova, Bo Jacobsson, Panagiotis Tsiartas, Ivana Musilova
INTRODUCTION: This study aimed to identify whether microbial invasion of the amniotic cavity and/or intra-amniotic inflammation in women with late preterm prelabor rupture of membranes (PPROM) was associated with changes in concentrations of soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF) and its ratio in maternal serum, and whether placental features consistent with maternal vascular malperfusion further affect their concentrations. MATERIAL AND METHODS: This historical study included 154 women with singleton pregnancies complicated by PPROM between gestational ages 34+0 and 36+6 weeks...
March 21, 2024: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/38509261/dyslipidemia-lipid-lowering-agents-and-neuroendocrine-neoplasms-new-horizons
#32
REVIEW
Roberta Modica, Anna La Salvia, Alessia Liccardi, Alessia Cozzolino, Antonella Di Sarno, Flaminia Russo, Annamaria Colao, Antongiulio Faggiano
PURPOSE: Neuroendocrine neoplasms (NENs) are a heterogeneous group of malignancies originating from cells with a neuroendocrine phenotype. The complex relationship between lipid metabolism and cancer is gaining interest and a potential anti-cancer effect of lipid lowering agents is being considered. This review aims to discuss the current understanding and treatment of dyslipidaemia in NENs, focusing on the role of lipid lowering agents, including new therapeutic approaches, and future perspectives as possible tool in cancer prevention and tumor-growth control...
March 20, 2024: Endocrine
https://read.qxmd.com/read/38507163/identifying-potential-uses-for-green-roof-discharge-based-on-its-physical-chemical-microbiological-quality
#33
JOURNAL ARTICLE
Jonas Onis Pessoa, Daniel Gustavo Allasia Piccilli, Cristiano Gabriel Persch, Rutineia Tassi, Jordana Georgin, Dison S P Franco, Yamil L de O Salomón
Green roofs are promising tools in sustainable urban planning, offering benefits such as stormwater management, energy savings, aesthetic appeal, and recreational spaces. They play a crucial role in creating sustainable and resilient cities, providing both environmental and economic advantages. Despite these benefits, concerns persist about their impact on water quality, especially for non-potable use, as conflicting results are found in the literature. This study presents a comparative analysis of the quantity and quality of water drained from an extensive green roof against an adjacent conventional rooftop made of fiber-cement tiles in subtropical Brazil...
March 20, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38506926/primary-biliary-cholangitis-drug-evaluation-and-regulatory-approval-where-do-we-go-from-here
#34
JOURNAL ARTICLE
David Ej Jones, Ulrich Beuers, Alan Bonder, Marco Carbone, Emma Culver, Jessica Dyson, Robert G Gish, Bettina E Hansen, Gideon Hirschfield, Rebecca Jones, Kris Kowdley, Andreas E Kremer, Keith Lindor, Marlyn Mayo, George Mells, James Neuberger, Martin Prince, Mark Swain, Atsushi Tanaka, Douglas Thorburn, Michael Trauner, Palak Trivedi, Martin Weltman, Andrew Yeoman, Cynthia Levy
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease. The management landscape was transformed 20 years ago with the advent of Ursodeoxycholic Acid (UDCA). Up to 40% of patients do not, however, respond adequately to UDCA and therefore still remain at risk of disease progression to cirrhosis. The introduction of Obeticholic acid (OCA) as second-line therapy for patients failing UDCA has improved outcomes for PBC patients. There remains, however, a need for better treatments for higher risk patients...
March 20, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38506589/synthesis-antidiabetic-and-antitubercular-evaluation-of-quinoline-pyrazolopyrimidine-hybrids-and-quinoline-4-arylamines
#35
JOURNAL ARTICLE
Nosipho Cele, Paul Awolade, Pule Seboletswe, Lungisani Khubone, Kolawole Olofinsan, Md Shahidul Islam, Audrey Jordaan, Digby F Warner, Parvesh Singh
Two libraries of quinoline-based hybrids 1-(7-chloroquinolin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine and 7-chloro-N-phenylquinolin-4-amine were synthesized and evaluated for their α-glucosidase inhibitory and antioxidant properties. Compounds with 4-methylpiperidine and para-trifluoromethoxy groups, respectively, showed the most promising α-glucosidase inhibition activity with IC50 =46.70 and 40.84 μM, compared to the reference inhibitor, acarbose (IC50 =51.73 μM). Structure-activity relationship analysis suggested that the cyclic secondary amine pendants and para-phenyl substituents account for the variable enzyme inhibition...
March 20, 2024: ChemistryOpen
https://read.qxmd.com/read/38505266/case-series-raw-whole-plant-based-nutrition-protocol-rapidly-reverses-symptoms-in-three-women-with-systemic-lupus-erythematosus-and-sj%C3%A3-gren-s-syndrome
#36
Brooke Goldner, Kara Livingston Staffier
Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) are chronic autoimmune diseases. Symptoms of SLE can vary widely but often include fatigue, pain, photosensitivity, and, in some cases, nephritis. SS is frequently characterized by extreme dry eye and mouth, resulting from damage to moisture-producing glands, and is often present in combination with SLE. While the health benefits of plant-based diets have been well-established with respect to weight and cardiometabolic outcomes, less research is available to support the role of diet in treatment and management of autoimmune disease...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38503362/pathophysiology-and-management-of-enteric-hyperoxaluria
#37
REVIEW
Jordan Desenclos, Valentine Forté, Cécile Clément, Michel Daudon, Emmanuel Letavernier
Enteric hyperoxaluria is a metabolic disorder resulting from conditions associated with fatty acid malabsorption and characterized by an increased urinary output of oxalate. Oxalate is excessively absorbed in the gut and then excreted in urine where it forms calcium oxalate crystals, inducing kidney stones formation and crystalline nephropathies. Enteric hyperoxaluria is probably underdiagnosed and may silently damage kidney function of patients affected by bowel diseases. Moreover, the prevalence of enteric hyperoxaluria has increased because of the development of bariatric surgical procedures...
March 17, 2024: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/38503231/influence-of-elevated-temperature-on-the-species-and-mobility-of-chromium-in-ferrous-sulfate-amended-contaminated-soil
#38
JOURNAL ARTICLE
Ruolin Zhao, Xinqing Zhang, Yiwen Zhou, Jining Li, Binglin Guo, Keishi Oyama, Chiharu Tokoro
Ferrous sulfate (FeSO4 ) combined with acid pretreatment is usually employed to remediate contaminated soils containing Cr(VI). However, the long-term efficiency of this stabilization method is important for its sustainability. In this study, a gradient temperature-elevating exposure test was employed to investigate the stability of Cr in FeSO4 -remediated soil when exposed to elevated temperatures (40 °C, 120 °C, and 500 °C), possibly caused by hot weather and/or wildfires. The results of chemical extraction and X-ray absorption near edge structure spectroscopy (XANES) showed that the Cr(VI) in contaminated soil was successfully transformed to Cr(III) after stabilization, resulting in the dramatic decrease of water-leachable Cr(VI)...
March 18, 2024: Journal of Environmental Management
https://read.qxmd.com/read/38502695/phenotypic-screen-of-sixty-eight-colorectal-cancer-cell-lines-identifies-ceacam6-and-ceacam5-as-markers-of-acid-resistance
#39
JOURNAL ARTICLE
Johanna Michl, Bobby White, Stefania Monterisi, Walter F Bodmer, Pawel Swietach
Elevated cancer metabolism releases lactic acid and CO2 into the under-perfused tumor microenvironment, resulting in extracellular acidosis. The surviving cancer cells must adapt to this selection pressure; thus, targeting tumor acidosis is a rational therapeutic strategy to manage tumor growth. However, none of the major approved treatments are based explicitly on disrupting acid handling, signaling, or adaptations, possibly because the distinction between acid-sensitive and acid-resistant phenotypes is not clear...
March 26, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38501683/per-and-polyfluoroalkyl-substances-in-food-packaging-migration-toxicity-and-management-strategies
#40
JOURNAL ARTICLE
Drake W Phelps, Lindsey V Parkinson, Justin M Boucher, Jane Muncke, Birgit Geueke
PFASs are linked to serious health and environmental concerns. Among their widespread applications, PFASs are known to be used in food packaging and directly contribute to human exposure. However, information about PFASs in food packaging is scattered. Therefore, we systematically map the evidence on PFASs detected in migrates and extracts of food contact materials and provide an overview of available hazard and biomonitoring data. Based on the FCCmigex database, 68 PFASs have been identified in various food contact materials, including paper, plastic, and coated metal, by targeted and untargeted analyses...
March 19, 2024: Environmental Science & Technology
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