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Dong-Keon Lee, Ji-Hee Kim, Joohwan Kim, Seunghwan Choi, MinSik Park, Wonjin Park, Suji Kim, Kyu-Sun Lee, Taesam Kim, Jiwon Jung, Yoon Kyung Choi, Kwon-Soo Ha, Moo-Ho Won, Timothy R Billiar, Young-Guen Kwon, Young-Myeong Kim
Regulated in development and DNA damage responses (REDD)-1, an inhibitor of mammalian target of rapamycin (mTOR), is induced by various cell stressors, including LPS, a major player in the pathogenesis of endotoxemic shock. However, the pathologic role of REDD-1 in endotoxemia is largely unknown. We found that LPS increased REDD-1 expression, nuclear transcription factor-κB (NF-κB) activation, and inflammation and that these responses were suppressed by REDD-1 knockdown and in REDD-1+/- macrophages. REDD-1 overexpression stimulated NF-κB-dependent inflammation without additional LPS stimulation...
March 16, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Cristian V Francavilla, Francesco Sessa, Monica Salerno, Giuseppe D Albano, Ines Villano, Giovanni Messina, Fabio Triolo, Lorenzo Todaro, Maria Ruberto, Gabriella Marsala, Orazio Cascio, Maria P Mollica, Vincenzo Monda, Giuseppe Cibelli, Anna Valenzano, Christian Zammit, Marcellino Monda, Antonietta Messina
Background: After long-term intensive training, considerable morphological and functional heart changes occur in professional athletes. Such changes arise progressively and regress upon interruption of the physical activity. Morphological and functional alterations on heart are known as "Athlete's heart" condition. Objective: This study aims to compare echocardiographic parameters in two different groups of professional athletes. Furthermore, a prospective study is performed analyzing the echocardiographic changes occurring in 12 professional players in 3 years of follow-up...
2018: Frontiers in Physiology
Stefanie Pietsch, Petra Jansen
This study investigates the influence of specific soccer training with the non-dominant leg on mental rotation performance of 20 adolescent soccer players between 10 and 11 years of age. While the experimental group performed soccer specific tasks only with the non-dominant foot once a week for 10 weeks, the control group absolved the same exercises with the dominant foot for the same period of time. Both groups performed a mental rotation task and shot, dribbling and ball control tests before and after the 10 week intervention...
2018: Frontiers in Psychology
Tea Galic, Domagoj Kuncic, Tina Poklepovic Pericic, Ivan Galic, Frane Mihanovic, Josko Bozic, Mark Herceg
BACKGROUND/AIMS: The increasing popularity of participating in sports activities among children and adolescents has increased the risk of sports-retaled orofacial and dental injuries. Therefore, it is important to establish efficient preventive strategies regarding sports-related dental trauma The aim of this study was to evaluate the occurrence of sports-related dental injuries in young athletes and to compare the frequency of such injuries between high-risk and medium-risk sports, along with assessing athletes' attitudes and habits regarding mouthguard use...
March 11, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Benoît Gillet, Mickaël Begon, Marine Diger, Christian Berger-Vachon, Isabelle Rogowski
OBJECTIVE: To assess the effect of a history of shoulder problems on the shoulder flexibility and strength in young competitive tennis players. DESIGN: Cross-sectional study. PARTICIPANTS: Ninety-one competitive and asymptomatic tennis players aged between 8 and 15 years old were divided into two groups according to the presence or absence of a history of shoulder problems. OUTCOME MEASURES: Glenohumeral joint ranges of motion and the strength of eight shoulder muscles were bilaterally assessed...
February 2, 2018: Physical Therapy in Sport
Luiz H P Vieira, Sérgio A Cunha, Renato Moraes, Fabio A Barbieri, Rodrigo Aquino, Lucas de P Oliveira, Martina Navarro, Bruno L S Bedo, Paulo R P Santiago
PURPOSE: The purpose of this study was to compare the kicking performance of young soccer players in the U9 to U20 age groups. METHOD: Three hundred and sixty-six Brazilian players were evaluated on an official pitch using three-dimensional kinematics to measure (300 Hz) ball velocity (Vball ), foot velocity (Vfoot ), Vball /Vfoot ratio, last stride length, and distance between the support foot and the ball. Simultaneously, a two-dimensional procedure was also conducted to compute (60 Hz) the mean radial error, bivariate variable error, and accuracy...
March 7, 2018: Research Quarterly for Exercise and Sport
A Notarnicola, I Covelli, G Maccagnano, R Marvulli, L Mastromauro, G Ianieri, S Boodhoo, A Turitto, L Petruzzella, G Farì, F P Bianchi, S Tafuri, B Moretti
The aim of this study is to investigate the effects of extracorporeal shock wave therapy (ESWT) on muscle rheological and functional properties in a population of young athletes. Thirty-two football and basketball players were recruited and randomized into two groups. The athletes underwent three sessions of therapy administered every five days to the thigh muscles. The treatment consisted of ESWT (electromagnetic generator, Energy Flux Density=0.03 mJ/mm2) or a placebo treatment bilaterally on the quadricep and femoral bicep muscles...
January 2018: Journal of Biological Regulators and Homeostatic Agents
Piergiorgio Francia, Sonia Toni, Giulia Iannone, Giuseppe Seghieri, Barbara Piccini, Alessandro Vittori, Ugo Santosuosso, Emilio Casalini, Massimo Gulisano
BACKGROUND/OBJECTIVE: It is known that patients with diabetes can develop limited joint mobility (LJM) and that this can depend on the metabolic control maintained and the duration of the disease. The aims of this study were to verify the presence of ankle joint mobility (AJM) deficits in both plantar and dorsiflexion in young type 1 diabetic patients (T1D) considering also the possible role of sport practiced as a further factor, able to modify AJM. METHODS: AJM was evaluated by an inclinometer in 82 T1D patients (M/F: 48/34), mean age 12...
March 1, 2018: Pediatric Diabetes
Young-Ho Lee, Ayyalusamy Ramamoorthy
Misfoding and amyloid aggregation of intrinsically disordered proteins (IDPs) are implicated in a variety of diseases. Studies have shown that membrane plays important roles on the formation of intermediate structures of IDPs that can initiate (and/or speed-up) amyloid aggregation to form fibers. The process of amyloid aggregation also disrupts membrane to cause cell death in amyloid diseases like Alzheimer's disease and type-2 diabetes. On the other hand, recent studies reported the membrane fusion properties of amyloid fibers...
March 1, 2018: Protein Science: a Publication of the Protein Society
Brianna D McKay, Amelia A Miramonti, Zachary M Gillen, Todd J Leutzinger, Alegra I Mendez, Nathaniel D M Jenkins, Joel T Cramer
The purpose of the present report was to provide test- and position-specific normative reference values for combine test results based on a large, nationally-representative sample of high school-aged American football players in their freshman, sophomore, and junior classes. Cross-sectional anthropometric and performance data were obtained from 12 different high school American football recruiting combines between March 7, 2015 and January 9, 2016 across the United States. Subjects included a sample (n=7,478) of high school-aged American football athletes in their junior (n=3,779), sophomore (n=2,514), and freshman (n=1,185) classes...
February 27, 2018: Journal of Strength and Conditioning Research
Joanna Orysiak, Konrad Witek, Jadwiga Malczewska-Lenczowska, Agnieszka Zembron-Lacny, Andrzej Pokrywka, Dariusz Sitkowski
The aim of this study was to determine the effects of 17 days of training during preparation for the Ice Hockey Under 18 World Championship of the Polish ice hockey national team on the mucosal immune function and monitor upper respiratory tract infection (URTI) incidence before, during and after the competition. Twelve male ice hockey players (age 17.7±0.5 years) were recruited for this study. The first saliva/blood collection took place at the beginning of the training camp (without training at the training camp), the second one was conducted on the 9th day of the training camp immediately after the intensification of training, and the third collection was carried out on the 13th day of training (4 days before leaving for the World Championship) in the tapering phase...
February 27, 2018: Journal of Strength and Conditioning Research
Damien Young, Laurent Mourot, Marco Beato, Giuseppe Coratella
The aims of the current study were to examine the physical and physiological demands of elite under-21 male hurling match-play across halves of play and between positions. Global positioning systems (10-Hz) and heart rate (HR) monitors were used to collect data from 95 players during 10 games. Total distance (TD), relative speed, high-speed running (HSR), sprint distance, total sprints and mean length of sprint was 6688 ± 942 m, 112 ± 16 m·min, 661 ± 203 m, 274 ± 111 m, 18 ± 8 and 16 ± 5 m respectively...
February 27, 2018: Journal of Strength and Conditioning Research
Georgi Tchernev, Yavor Grigorov, Stanislav Philipov, Anastasiya Chokoeva, Uwe Wollina, Torello Lotti, Jose Cardoso, Irina Yungareva, Ilia Lozev, Georgi Konstantinov Maximov
BACKGROUND: Subungual exostosis is a relatively uncommon, benign osteocartilaginous tumor of the distal phalanx of the toes or fingers in young adults, considered as a rare variant of osteochondroma. Differential diagnoses include subungual verruca (viral wart), pyogenic granuloma, osteochondroma, amelanotic subungual melanoma and glomus tumour. Misdiagnosis and total onychodystrophy frequently occur as a result of late treatment or inadequate treatment strategy. Dermoscopy could be a useful technique, involved in the diagnostic process, although X-ray examination and histopathology are mandatory for the diagnosis...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
James Krieger, Ji Young Lee, Ingo H Greger, Ivet Bahar
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are key players in synaptic transmission and plasticity. They are composed of four subunits, each containing four functional domains, the quaternary packing and collective structural dynamics of which are important determinants of their molecular mechanism of function. With the explosion of structural studies on different members of the family, including the structures of activated open channels, the mechanisms of action of these central signaling machines are now being elucidated...
February 23, 2018: Neuroscience Letters
Aleksander Błażkiewicz, Monika Grygorowicz, Arkadiusz Białostocki, Dariusz Czaprowski
BACKGROUND: Characteristic types of actions and training/matches loads of football goalkeepers show that goalkeeper's performance differs from other football's formations. Such situation may predispose to the occurrence of other kinds of injuries in this position. The aim of this study was to analyse epidemiology of injuries in young football goalkeepers. METHODS: 48 football goalkeepers (aged:15.2±1.9 years) were filled the questionnaire aimed at collecting information about all injuries sustained within 12 months before the data collection...
February 26, 2018: Journal of Sports Medicine and Physical Fitness
Alexandre Moreira, Marcelo Massa, Carlos R Thiengo, Rafael Alan Rodrigues Lopes, Marcelo R Lima, Roel Vaeyens, Wesley P Barbosa, Marcelo S Aoki
The aim of this study was to examine the influence of hormonal status, anthropometric profile, sexual maturity level, and physical performance on the technical abilities of 40 young male soccer players during small-sided games (SSGs). Anthropometric profiling, saliva sampling, sexual maturity assessment (Tanner scale), and physical performance tests (Yo-Yo and vertical jumps) were conducted two weeks prior to the SSGs. Salivary testosterone was determined by the enzyme-linked immunosorbent assay method. Technical performance was determined by the frequency of actions during SSGs...
December 2017: Biology of Sport
Hyunyong Shim, Seungwan Lee, Miseung Koo, Jinsook Kim
Background and Objectives: To prevent noise induced hearing losses caused by listening to music with personal listening devices for young adults, this study was aimed to measure output levels of an MP3 and to identify preferred listening levels (PLLs) depending on earphone types, music genres, and listening durations. Subjects and Methods: Twenty-two normal hearing young adults (mean=18.82, standard deviation=0.57) participated. Each participant was asked to select his or her most PLLs when listened to Korean ballade or dance music with an earbud or an over-the-ear earphone for 30 or 60 minutes...
February 26, 2018: Journal of Audiology & Otology
Estibaliz González-Fernández, Hey-Kyeong Jeong, Masahiro Fukaya, Hyukmin Kim, Rabia R Khawaja, Isha N Srivastava, Ari Waisman, Young-Jin Son, Shin H Kang
Oligodendrocytes (OLs), the myelin-forming CNS glia, are highly vulnerable to cellular stresses, and a severe myelin loss underlies numerous CNS disorders. Expedited OL regeneration may prevent further axonal damage and facilitate functional CNS repair. Although adult OL progenitors (OPCs) are the primary players for OL regeneration, targetable OPC-specific intracellular signaling mechanisms for facilitated OL regeneration remain elusive. Here, we report that OPC-targeted PTEN inactivation in the mouse, in contrast to OL-specific manipulations, markedly promotes OL differentiation and regeneration in the mature CNS...
February 20, 2018: ELife
Leonie Waldenmeier, Christoph Evers, Michael Uder, Rolf Janka, Frank Friedrich Hennig, Milena Liese Pachowsky, Götz Hannes Welsch
Objective To evaluate and characterize the appearance of articular cartilage in the tibiofemoral joint of young professional soccer players using T2-relaxation time evaluation on magnetic resonance imaging (MRI). Design In this study, we included 57 male adolescents from the youth academy of a professional soccer team. The MRI scans were acquired of the knee joint of the supporting leg. An "early unloading" (minute 0) and "late unloading" (minute 28) T2-sequence was included in the set of images...
February 1, 2018: Cartilage
Athanasios Chatzinikolaou, Konstantinos Michaloglou, Alexandra Avloniti, Diamanda Leontsini, Chariklia K Deli, Dimitris Vlachopoulos, Luis Gracia-Marco, Sotirios Arsenis, Ioannis Athanailidis, Dimitrios Draganidis, Athanasios Z Jamurtas, Craig A Williams, Ioannis G Fatouros
PURPOSE: Τo investigate the effect of a complex, short-term strength/power training protocol on performance and body composition of elite early-adolescent soccer players. METHODS: Twenty-two players (14-15 years) were randomly assigned to (a) an experimental (EG, n=12, participated in a 5-week training protocol with traditional multi-joint power resistance exercises, Olympic-style lifts, plyometric drills and speed work, four times/week) or (b) a control group (CG, n=10)...
February 12, 2018: International Journal of Sports Physiology and Performance
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