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https://www.readbyqxmd.com/read/28093932/involvement-of-p53-and-bcl-2-in-sensory-cell-degeneration-in-aging-rat-cochleae
#1
Yang Xu, Wei Ping Yang, Bo Hua Hu, Shiming Yang, Donald Henderson
CONCLUSION: p53 and Bcl-2 (B-cell lymphoma 2) are involved in the process of sensory cell degeneration in aging cochleae. OBJECTIVE: To determine molecular players in age-related hair cell degeneration, this study examined the changes in p53 and Bcl-2 expression at different stages of apoptotic and necrotic death of hair cells in aging rat cochleae. METHODS: Young (3-4 months) and aging (23-24 months) Fisher 344/NHsd rats were used. The thresholds of the auditory brainstem response (ABR) were measured to determine the auditory function...
January 17, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28092197/from-the-mouths-of-social-media-users-a-focus-group-study-exploring-the-social-casino-gaming-online-gambling-link
#2
Hyoun S Kim, Michael J A Wohl, Rina Gupta, Jeffrey Derevensky
Background and aims The potential link between social casino gaming and online gambling has raised considerable concerns among clinicians, researchers and policy makers. Unfortunately, however, there is a paucity of research examining this potential link, especially among young adults. This represents a significant gap given young adults are frequently exposed to and are players of social casino games. Methods To better understand the potential link between social casino games and online gambling, we conducted three focus groups (N = 30) at two large Canadian Universities with college students who were avid social media users (who are regularly exposed to social casino games)...
March 2016: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28092187/online-and-live-regular-poker-players-do-they-differ-in-impulsive-sensation-seeking-and-gambling-practice
#3
Servane Barrault, Isabelle Varescon
Background and aims Online gambling appears to have special features, such as anonymity, speed of play and permanent availability, which may contribute to the facilitation and increase in gambling practice, potentially leading to problem gambling. The aims of this study were to assess sociodemographic characteristics, gambling practice and impulsive sensation seeking among a population of regular poker players with different levels of gambling intensity and to compare online and live players. Methods 245 regular poker players (180 online players and 65 live players) completed online self-report scales assessing sociodemographic data, pathological gambling (SOGS), gambling practice (poker questionnaire) and impulsive sensation seeking (ImpSS)...
March 2016: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28090138/agility-training-in-young-elite-soccer-players-promising-results-compared-to-change-of-direction-drills
#4
A Chaalali, M Rouissi, M Chtara, A Owen, N L Bragazzi, W Moalla, A Chaouachi, M Amri, K Chamari
The aim of this study was to compare the effect of two different training programmes - change of direction (COD) vs. agility (AG) - on straight sprint (SS), COD and AG test performances in young elite soccer players. Thirty-two soccer players (age: 14.5±0.9 years; height: 171.2±5.1 cm; body mass: 56.4±7.1 kg, body fat: 10.3±2.3%) participated in a short-term (6 weeks) training study. Players were randomly assigned to two experimental groups - training with change of direction drills (COD-G, n=11) or using agility training (AG-G, n= 11) - and to a control group (CON-G, n=10)...
December 2016: Biology of Sport
https://www.readbyqxmd.com/read/28088438/a-snapshot-of-urban-adolescent-women-s-contraceptive-knowledge-at-the-onset-of-a-community-larc-promotion-initiative
#5
K B Greenberg, S C Jenks, N G Piazza, B R Malibiran, C A Aligne
STUDY OBJECTIVE: To contextualize young women's knowledge and attitudes regarding contraception at the outset of an intervention promoting long-acting reversible contraceptives (LARC) for teen pregnancy prevention. DESIGN: and Setting: Our intervention is based on diffusion of innovation theory, and at the outset we were interested in likely early adopters' existing knowledge and attitudes towards contraception. This mixed methods study consists of focus groups within positive youth development programs in Rochester, New York; we discussed young women's knowledge and sources of information for all FDA-approved contraceptive methods...
January 11, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28054492/match-running-performance-and-skill-execution-improves-with-age-but-not-the-number-of-disposals-in-young-australian-footballers
#6
Paul B Gastin, Christie Tangalos, Lorena Torres, Sam Robertson
This study investigated age-related differences in maturity, physical and functional characteristics and playing performance in youth Australian Football (AF). Young male players (n = 156) were recruited from 12 teams across 6 age groups (U10-U15) of a recreational AF club. All players were tested for body size, maturity and fitness. Player performance was assessed during a match in which disposals (kicks and handballs) and their effectiveness were coded from a video recording and match running performance measured using Global Positioning System...
January 5, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28050443/abdominal-necrotising-fascitis-mimicking-peritonitis-in-a-gatka-playing-indian-male-a-case-report
#7
Sonika Jha, Devinder Pal Singh
The present case report is of abdominal Necrotising Fascitis in a young Gatka player. The patient was clinically diagnosed to have peritonitis with plan for laparotomy but since ultrasound abdomen showed no free intra-abdominal fluid and any other pathology a Contrast Enhanced Computed tomography (CECT) abdomen was done. CECT showed fluid collections in rectus sheath and superficial fascia. Patient was thus, diagnosed as having abdominal myofascitis and treated accordingly. A review of literature showed that such a clinical presentation of this disease is quite rare and can lead to unnecessary laparotomy and delay in diagnosis leading to morbidity...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28050360/gender-difference-in-aerobic-capacity-and-the-contribution-by-body-composition-and-haemoglobin-concentration-a-study-in-young-indian-national-hockey-players
#8
Hanjabam Barun Sharma, Jyotsna Kailashiya
INTRODUCTION: Although gender difference in aerobic capacity is known, the contributing factors have been researched seldom. AIM: To investigate the gender gap and the contribution by percentage Body Fat (BF), Body Mass Index (BMI) and haemoglobin concentration Hb. MATERIALS AND METHODS: The study was conducted on 30 (17 males, 13 females) training status matched young hockey players. Healthy players who were playing upto national level competition were included...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28046124/changes-of-ovarian-microrna-profile-in-long-living-ames-dwarf-mice-during-aging
#9
Augusto Schneider, Scot J Matkovich, Berta Victoria, Lina Spinel, Andrzej Bartke, Pawel Golusinski, Michal M Masternak
The Ames dwarf (df/df) mice have extended longevity and can preserve the ovarian reserve longer than Normal (N) mice. Based on this, the aim of our study was to evaluate the ovarian microRNA (miRNA) profile in young and aged df/df and N mice. Ovarian tissue was collected at 5-6 months and at 21-22 months of age for miRNA sequencing. We detected a total of 404 miRNAs in the ovarian samples, from which the abundance of 22 and 33 miRNAs changed with age in N and df/df mice, respectively. Of these, only three miRNAs were commonly regulated with age between N and df/df mice, indicating a very divergent miRNA profile between genotypes...
2017: PloS One
https://www.readbyqxmd.com/read/28035209/folate-receptor-targeted-diagnostics-and-therapeutics-for-inflammatory-diseases
#10
REVIEW
Young-Su Yi
Inflammation, an innate immune response mediated by macrophages, forms the first line of defence to protect our body from the invasion of various pathogens. Although inflammation is a defensive response, chronic inflammation has been regarded as the major cause of many types of human diseases such as inflammatory/autoimmune diseases, cancers, neurological diseases, and cardiovascular diseases. Folate receptor (FR) is a cell surface glycosylphosphatidylinositol (GPI)-anchored glycoprotein, and its three isoforms, FR-α, FR-β, and FR-γ, are found in humans...
December 2016: Immune Network
https://www.readbyqxmd.com/read/28033652/high-ankle-injury-rate-in-adolescent-basketball-a-3-year-prospective-follow-up-study
#11
K Pasanen, T Ekola, T Vasankari, P Kannus, A Heinonen, U M Kujala, J Parkkari
This prospective study investigated the incidence and pattern of acute time-loss injuries in young female and male basketball players. Eight basketball teams (n=201; mean age 14.85±1.5) participated in the follow-up study (2011-2014). The coaches recorded player participation in practices and games on a team diary. A study physician contacted the teams once a week to check new injuries and interviewed the injured players. In total, 158 injuries occurred. The overall rate of injury (per 1000 hours) was 2.64 (95% CI 2...
December 29, 2016: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28031770/soccer-players-cultural-capital-and-its-impact-on-migration
#12
Jožef Križaj, Bojan Leskošek, Janez Vodičar, Mojca Doupona Topič
The purpose of this study was to identify factors that constituted the cultural capital among soccer players. We assumed that in the increasingly globalized world of professional soccer, a player's success would often depend on migrating and adjusting to life in other countries. Willingness to migrate and successful adjustment are tied to player's previous attitudes and/or behaviours (habitus), significant support from others, including family members, and previous experiences and success in sports and education...
December 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28031768/optimization-of-game-formats-in-u-10-soccer-using-logistic-regression-analysis
#13
Mario Amatria, Daniel Lapresa, Javier Arana, M Teresa Anguera, Belén Garzón
Small-sided games provide young soccer players with better opportunities to develop their skills and progress as individual and team players. There is, however, little evidence on the effectiveness of different game formats in different age groups, and furthermore, these formats can vary between and even within countries. The Royal Spanish Soccer Association replaced the traditional grassroots 7-a-side format (F-7) with the 8-a-side format (F-8) in the 2011-12 season and the country's regional federations gradually followed suit...
December 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28026984/examining-changes-to-center-of-pressure-during-the-first-trials-of-wii-gameplay
#14
Rebecca Reed-Jones, Laura Carvalho, Chelsey Sanderson, William Montelpare, Nicholas Murray, Douglas Powell
OBJECTIVE: Use of the Nintendo Wii™ as a balance assessment and rehabilitation tool continues to grow. One advantage of the Wii is that games can serve as a virtual reality training tool; however, a disadvantage of the Wii is the human-machine interface and the learning effect over multiple trials. The purpose of this study was to assess changes in postural control during Wii gameplay over a series of trials in novice players. MATERIALS AND METHODS: Thirty-one university athletes (aged 18-25 years) completed four trials of the Nintendo Wii Fit™ soccer heading (SH) balance game...
December 27, 2016: Games for Health
https://www.readbyqxmd.com/read/28017518/effectiveness-of-a-stress-management-pilot-program-aimed-at-reducing-the-incidence-of-sports-injuries-in-young-football-soccer-players
#15
Aurelio Olmedilla-Zafra, Victor J Rubio, Enrique Ortega, Alexandre García-Mas
OBJECTIVES: Several attempts to reduce the incidence of sport injuries using psychosocial interventions produced fruitful, although inconclusive results. This paper presents the effectiveness and implementation issues of a pilot 3-month stress-management and muscle relaxation program aimed at reducing sport injury incidence. DESIGN: Pre-post treatment-non treatment group comparison. PROGRAM ADMINISTRATION: The program was administered by a trained psychologist on a once-a-week, 1-h session basis...
September 6, 2016: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28002727/allergen-exposure-when-timing-is-everything
#16
Tanel Mahlakõiv, David Artis
It is known that young children exposed to allergens are prone to develop asthma later in life. In this issue of Immunity, de Kleer et al. (2016) identify IL-33 as a key player in the developing lung for sensitization to environmental allergens and airway hyperreactivity.
December 20, 2016: Immunity
https://www.readbyqxmd.com/read/27993162/tet-enzymes-double-agents-in-the-transposable-element-host-genome-conflict
#17
Patricia Gerdes, Sandra R Richardson, Geoffrey J Faulkner
The mouse genome is replete with retrotransposon sequences, from evolutionarily young elements with mutagenic potential that must be controlled, to inactive molecular fossils whose sequences can be domesticated over evolutionary time to benefit the host genome. In an exciting new study, de la Rica and colleagues have uncovered a complex relationship between ten-eleven translocation (TET) proteins and retrotransposons in mouse embryonic stem cells (ESCs), implicating TETs as enhancers in the exaptation and function of retroelement sequences...
December 20, 2016: Genome Biology
https://www.readbyqxmd.com/read/27991485/construct-validity-of-tests-that-measure-kick-performance-for-young-soccer-players-based-on-cluster-analysis-exploring-the-relationship-between-coaches-rating-and-actual-measures
#18
Luiz H P Vieira, Vitor L DE Andrade, Rodrigo L Aquino, Renato Moraes, Fabio A Barbieri, Sérgio A Cunha, Bruno L Bedo, Paulo R Santiago
BACKGROUND: The main aim of this study was to verify the relationship between the classification of coaches and actual performance in field tests that measure the kicking performance in young soccer players, using the K--means clustering technique. METHODS: Twenty--three U--14 players performed eight tests to measure their kicking performance. Four experienced coaches provided a rating for each player as follows: 1--poor, 2--below average, 3--average, 4--very good, 5-excellent as related to three parameters (i...
December 16, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27990225/quantifying-inter-segmental-coordination-during-the-instep-soccer-kicks
#19
Yumeng Li, Marion Alexander, Cheryl Glazebrook, Jeff Leiter
In order to generate a high ball speed in soccer, the inter-segmental coordination of the kicking leg is critical. The purpose of this study was to quantify the coordination between the thigh and shank movement in the sagittal plane during instep kicks. Eleven female soccer players were video recorded using a high-speed (80 Hz) video camera during penalty kicks. Hip, knee and ankle joint centers of the right leg were digitized, and the movement was analyzed using Dartfish TeamPro (6.0). The thigh and shank segment angles were generated, and the coordination was quantified using the cross-correlation and the vector coding method...
2016: International Journal of Exercise Science
https://www.readbyqxmd.com/read/27983708/the-hk2-dependent-warburg-effect-and-mitochondrial-oxidative-phosphorylation-in-cancer-targets-for-effective-therapy-with-3-bromopyruvate
#20
REVIEW
Paweł Lis, Mariusz Dyląg, Katarzyna Niedźwiecka, Young H Ko, Peter L Pedersen, Andre Goffeau, Stanisław Ułaszewski
This review summarizes the current state of knowledge about the metabolism of cancer cells, especially with respect to the "Warburg" and "Crabtree" effects. This work also summarizes two key discoveries, one of which relates to hexokinase-2 (HK2), a major player in both the "Warburg effect" and cancer cell immortalization. The second discovery relates to the finding that cancer cells, unlike normal cells, derive as much as 60% of their ATP from glycolysis via the "Warburg effect", and the remaining 40% is derived from mitochondrial oxidative phosphorylation...
December 15, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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