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https://www.readbyqxmd.com/read/29754496/detection-of-loco-regional-recurrence-in-malignant-head-and-neck-tumors-a-comparison-of-ct-mri-and-fdg-pet-ct
#1
Eun Soo Kim, Dae Young Yoon, Ji Yoon Moon, Sora Baek, You Mie Han, Young Lan Seo, Eun Joo Yun
Background The early and accurate detection of local or regional recurrence of head and neck tumor is critically important. Purpose To compare the diagnostic accuracy of contrast-enhanced computed tomography (CT), contrast-enhanced magnetic resonance imaging (MRI), and fluorodeoxyglucose (FDG) positron emission tomography (PET)-CT, alone and in combination, in detecting the locoregional recurrence of malignant head and neck tumor. Material and Methods A total of 93 patients with loco-regional recurrence of malignant head and neck tumors underwent CT, MRI, and PET-CT within 30 days before surgery...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29751364/ictal-and-interictal-electric-source-imaging-in-presurgical-evaluation-a-prospective-study
#2
Praveen Sharma, Michael Scherg, Lars H Pinborg, Martin Fabricius, Guido Rubboli, Birthe Pedersen, Anne-Mette Leffers, Peter Uldall, Bo Jespersen, Jannick Brennum, Otto Mølby Henriksen, Sándor Beniczky
BACKGROUND: Accurate localization of the epileptic focus is essential for surgical treatment of patients with drug- resistant epilepsy. EEG source imaging (ESI) is increasingly used in presurgical evaluation. However, most previous studies analysed interictal discharges. Prospective studies comparing feasibility and accuracy of interictal (II) and ictal (IC) ESI are lacking. METHODS: We prospectively analysed long-term video EEG recordings (LTM) of patients admitted for presurgical evaluation...
May 11, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29703701/robust-revascularization-in-models-of-limb-ischemia-using-a-clinically-translatable-human-stem-cell-derived-endothelial-cell-product
#3
Mark G MacAskill, Jaimy Saif, Alison Condie, Maurits A Jansen, Thomas J MacGillivray, Adriana A S Tavares, Lucija Fleisinger, Helen L Spencer, Marie Besnier, Ernesto Martin, Giovanni Biglino, David E Newby, Patrick W F Hadoke, Joanne C Mountford, Costanza Emanueli, Andrew H Baker
Pluripotent stem cell-derived differentiated endothelial cells offer high potential in regenerative medicine in the cardiovascular system. With the aim of translating the use of a human stem cell-derived endothelial cell product (hESC-ECP) for treatment of critical limb ischemia (CLI) in man, we report a good manufacturing practice (GMP)-compatible protocol and detailed cell tracking and efficacy data in multiple preclinical models. The clinical-grade cell line RC11 was used to generate hESC-ECP, which was identified as mostly endothelial (60% CD31+ /CD144+ ), with the remainder of the subset expressing various pericyte/mesenchymal stem cell markers...
March 28, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29700279/using-tyrosinase-as-a-tri-modality-reporter-gene-to-monitor-transplanted-stem-cells-in-acute-myocardial-infarction
#4
Mei Liu, Yichun Wang, Mengting Li, Hongyan Feng, Qingyao Liu, Chunxia Qin, Yongxue Zhang, Xiaoli Lan
The study aimed to investigate the feasibility of noninvasive monitoring of bone marrow mesenchymal stem cells (MSCs) transduced with the tyrosinase reporter gene for acute myocardial infarction (AMI) with photoacoustic imaging (PAI), magnetic resonance imaging (MRI), and positron emission tomography (PET) in vitro and in vivo. MSCs were transduced with a lentivirus carrying a tyrosinase reporter gene. After transduction, the rate of 18 F-5-fluoro-N-(2-[diethylamino]ethyl)picolinamide (18 F-5-FPN) uptake was measured...
April 27, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29606149/influence-of-68-ga-dotatoc-on-sparing-of-normal-tissue-for-radiation-therapy-of-skull-base-meningioma-differential-impact-of-photon-and-proton-radiotherapy
#5
Falk Stade, Jan-Oliver Dittmar, Oliver Jäkel, Clemens Kratochwil, Uwe Haberkorn, Jürgen Debus, Stephanie E Combs
BACKGROUND: To evaluate the impact of 68 Ga-DOTATOC-PET on treatment planning and sparing of normal tissue in the treatment of skull base meningioma with advanced photons and protons. METHODS: From the institutional database consisting of 507 skull base meningiomas 10 patients were chosen randomly for the present analysis. Target volume definition was performed based on CT and MRI only, as well as with additional 68 Ga-DOTATOC-PET. Treatment plans were performed for Intensity Modulated Radiotherapy (IMRT) and proton therapy using active raster scanning on both target volumes...
April 2, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29554613/simultaneous-multiparametric-pet-mri-for-the-assessment-of-therapeutic-response-to-chemotherapy-or-concurrent-chemoradiotherapy-of-cervical-cancer-patients-preliminary-results
#6
Theresia Sarabhai, Alexander Tschischka, Vanessa Stebner, Felix Nensa, Axel Wetter, Rainer Kimmig, Michael Forsting, Ken Herrmann, Lale Umutlu, Johannes Grueneisen
PURPOSE: To assess the response to initial treatment strategies of cervical cancer using multiparametric-PET/MRI. MATERIAL AND METHODS: PET/MR-derived morphological (tumor size), functional (DWI, DCE-MRI) and metabolic (18F-FDG PET) parameters were acquired in pre- and posttreatment examinations of 8 patients. Besides RECIST- and PERCIST-criteria, functional quantitative parameters were used to assess therapeutic response. RESULTS: RECIST- and PERCIST-response criteria demonstrated high correlations for the differentiation between therapy-responders and non-responders, which was additionally reflected by functional (DWI, DCE-MRI) quantitative imaging parameters...
March 13, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29534416/-laparoscopic-radical-antegrade-modular-pancreatosplenectomy-for-left-sided-pancreatic-adenocarcinoma-analysis-of-12-cases
#7
X W Xu, R C Zhang, Y P Mou, Z Y Qian, C J Huang, Q C Zhu, W W Jin, Y C Zhou
Objective: To evaluate the safety and feasibility of laparoscopic radical antegrade modular pancreatosplenectomy(Lap-RAMPS) for left-sided pancreatic adenocarcinoma. Methods: Clinical data of total 12 patients underwent Lap-RAMPS for left-sided pancreatic adenocarcinoma at Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital from March 2016 to August 2017 were reviewed retrospectively.There were 7 male patients and 5 female patients, with median age of 60.5 years old(47-68 years old)...
March 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29524596/the-neurochemistry-of-agitation-in-alzheimer-s-disease-a-systematic-review
#8
REVIEW
Kathy Y Liu, Aisling E Stringer, Suzanne J Reeves, Robert J Howard
OBJECTIVE: To provide an up-to-date systematic review of the characteristics, methodology and findings of studies that have investigated the neurochemistry of agitation in Alzheimer's disease (AD). METHODS: Electronic databases were searched for published peer-reviewed articles which provided data on any neurotransmitter system in relation to agitation in AD. Screening of titles and abstracts and data extraction from full texts were conducted in duplicate. RESULTS: Forty-five studies were included...
May 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/29498535/patient-perspectives-on-repeated-mri-and-pet-ct-examinations-during-neoadjuvant-treatment-of-esophageal-cancer
#9
Lucas Goense, Alicia S Borggreve, Sophie E Heethuis, Astrid Lhmw van Lier, Richard van Hillegersberg, Stella Mook, Gert J Meijer, Peter Sn van Rossum, Jelle P Ruurda
OBJECTIVE: The perceived burden of diagnostic tests by patients during the assessment of esophageal cancer warrants attention with the current increase in repeated imaging for purposes of disease monitoring during and after treatment. The purpose of this prospective study was to evaluate the experienced burden associated with repeated MRI and positron emission tomography with integrated CT (PET/CT) examinations during neoadjuvant treatment for esophageal cancer from the perspective of the patient...
March 14, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29414560/the-relationship-between-structural-mri-fdg-pet-and-memory-in-temporal-lobe-epilepsy-preliminary-results
#10
Justus Berger, Michail Plotkin, Katharina Demin, Martin Holtkamp, Thomas Bengner
Structural and metabolic abnormalities of the temporal lobe are frequently found in temporal lobe epilepsy (TLE). In the present retrospective study, we investigated whether structural abnormalities evident in magnetic resonance imaging (MRI) and hypometabolism evident in [18 F]fluorodeoxyglucose positron emission tomography (FDG-PET) independently influence verbal and nonverbal learning and delayed memory in patients with TLE. Sixty-eight patients with refractory unilateral TLE (35 left TLE, 33 right TLE) were divided into three groups: (1) no evidence of pathology in either MRI or FDG-PET studies (MRI-/PET-, n=15), (2) temporal FDG-PET determined hypometabolism with normal MRI findings (MRI-/PET+, n=21), and (3) evidence of temporal abnormalities in both MRI and FDG-PET studies (MRI+/PET+, n=32)...
March 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29393268/integrated-68gallium-labelled-prostate-specific-membrane-antigen-11-positron-emission-tomography-magnetic-resonance-imaging-enhances-discriminatory-power-of-multi-parametric-prostate-magnetic-resonance-imaging
#11
Mohammad Al-Bayati, Johannes Grueneisen, Susanne Lütje, Lino M Sawicki, Saravanabavaan Suntharalingam, Stephan Tschirdewahn, Michael Forsting, Herbert Rübben, Ken Herrmann, Lale Umutlu, Axel Wetter
PURPOSE: To evaluate diagnostic accuracy of integrated 68Gallium labelled prostate-specific membrane antigen (68Ga-PSMA)-11 positron emission tomography (PET)/MRI in patients with primary prostate cancer (PCa) as compared to multi-parametric MRI. MATERIAL AND METHODS: A total of 22 patients with recently diagnosed primary PCa underwent clinically indicated 68Ga-PSMA-11 PET/CT for initial staging followed by integrated 68Ga-PSMA-11 PET/MRI. Images of multi-parametric magnetic resonance imaging (mpMRI), PET and PET/MRI were evaluated separately by applying Prostate Imaging Reporting and Data System (PIRADSv2) for mpMRI and a 5-point Likert scale for PET and PET/MRI...
2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29371410/intra-individual-comparison-of-tc-99m-mdp-bone-scan-and-the-psma-ligand-tc-99m-mip-1427-in-patients-with-osseous-metastasized-prostate-cancer
#12
Hendrik Rathke, Ali Afshar-Oromieh, Frederik L Giesel, Christophe Kremer, Paul Flechsig, Sabine Haufe, Walter Mier, Tim Holland-Letz, Maximilian de Bucourt, Thomas Armor, John Babich, Uwe Haberkorn, Clemens Kratochwil
To evaluate the detection rate of bone metastases obtained with the PSMA targeting tracer 99m Tc-MIP-1427 as opposed to the conventional bone scan with 99m Tc-MDP in a collective of advanced stage patients with known osseous metastasized prostate cancer. Methods: 21 Patients with known metastatic disease were staged with both, conventional bone scan and PSMA-ligand scintigraphy, within a time-frame of <10 days. Imaging included planar whole-body scans and SPECT or SPECT/CT with two bed positions 3 h after injection of either 500-750 MBq 99m Tc-MIP-1427 or 600-750 MBq 99m Tc-MDP...
January 25, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29323548/-18-f-fluorocholine-pet-whole-body-mri-in-the-staging-of-high-risk-prostate-cancer
#13
Ur Metser, Alejandro Berlin, Jaydeep Halankar, Grainne Murphy, Kartik S Jhaveri, Sangeet Ghai, Noam Tau
OBJECTIVE: The purpose of this study was to determine whether integrated 18 F-fluorocholine (FCH) PET whole-body MRI (PET/WBMRI) depicts lymph node and distant metastases in patients with high-risk prostate cancer more frequently than does conventional staging. SUBJECTS AND METHODS: A prospective study included 58 patients with untreated high-risk prostate cancer. After conventional staging (CT and bone scintigraphy), patients underwent FCH PET/WBMRI (n = 10) or FCH PET/CT and WBMRI (n = 48)...
March 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29318031/para-aortic-lymphadenectomy-in-advanced-stage-cervical-cancer-a-protocol-for-comparing-safety-feasibility-and-diagnostic-accuracy-of-surgical-staging-versus-pet-ct-paldisc-trial
#14
Casper Tax, Karin Abbink, Maroeska M Rovers, Ruud L M Bekkers, Petra L M Zusterzeel
Background: Currently, a PET-CT is used to assess the need for extended field radiotherapy of para-aortic lymph nodes (PALN) in International Federation of Gynaecology and Obstetrics (FIGO) stage IB2, IIA2-IVA (locally advanced stage) cervical cancer. A small study established a sensitivity and specificity estimate for PALN metastases of 50% (95% CI; 7-93%) and 83% (95% CI; 52-98%), respectively. Surgical staging of PALN may lead to a higher diagnostic accuracy. However, surgical staging of para-aortic lymph nodes in locally advanced stage cervical cancer is not common practice...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29274795/-splenic-sarcoidosis-diagnosed-by-us-guided-biopsy-about-a-case
#15
A Gaudemer, G Sauvet, A Hij, R Stanciu, D Farge-Bancel, J-P Algayres
INTRODUCTION: Splenic localisation of sarcoidosis is common but rare as unique location. We report a case diagnosed by US-guided biopsy. OBSERVATION: A 42-year-old woman presented atypic and recidivant epigastric pain. Abdominal ultrasound showed splenic hypoechoic nodules not characterizable with CT or MRI. PET-CT revealed hypermetabolism without any other abnormal metabolic activity. US-guided biopsy with small needle achieved diagnosis of isolated splenic sarcoidosis...
March 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29151054/effect-of-ephedrine-and-phenylephrine-on-brain-oxygenation-and-microcirculation-in-anaesthetised-patients-with-cerebral-tumours-study-protocol-for-a-randomised-controlled-trial
#16
Klaus Ulrik Koch, Anna Tietze, Joel Aanerud, Gorm von Öettingen, Niels Juul, Jens Christian Hedemann Sørensen, Lone Nikolajsen, Leif Østergaard, Mads Rasmussen
INTRODUCTION: During brain tumour surgery, vasopressor drugs are commonly administered to increase mean arterial blood pressure with the aim of maintaining sufficient cerebral perfusion pressure. Studies of the commonly used vasopressors show that brain oxygen saturation is reduced after phenylephrine administration, but unaltered by ephedrine administration. These findings may be explained by different effects of phenylephrine and ephedrine on the cerebral microcirculation, in particular the capillary transit-time heterogeneity, which determines oxygen extraction efficacy...
November 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/29104741/lymph-node-imaging-in-initial-staging-of-prostate-cancer-an-overview-and-update
#17
REVIEW
Jessica G Zarzour, Sam Galgano, Jonathan McConathy, John V Thomas, Soroush Rais-Bahrami
Accurate nodal staging at the time of diagnosis of prostate cancer is crucial in determining a treatment plan for the patient. Pelvic lymph node dissection is the most reliable method, but is less than perfect and has increased morbidity. Cross sectional imaging with computed tomography (CT) and magnetic resonance imaging (MRI) are non-invasive tools that rely on morphologic characteristics such as shape and size of the lymph nodes. However, lymph nodes harboring metastatic disease may be normal sized and non-metastatic lymph nodes may be enlarged due to reactive hyperplasia...
October 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/29098376/e-edmund-kim-hyung-jun-im-dong-soo-lee-keon-wook-kang-atlas-and-anatomy-of-pet-mri-pet-ct-and-spect-ct-springer-international-publishing-switzerland-2016-isbn-978-3-319-28650-1
#18
Giuseppe Danilo Di Stasio, Luigi Mansi
No abstract text is available yet for this article.
November 2, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29073488/solid-pseudopapillary-tumor-of-the-pancreas-clinical-features-and-imaging-findings
#19
Dong-Li Li, Hong-Sheng Li, Yi-Kai Xu, Quan-Shi Wang, Rui-Ying Chen, Fang Zhou
This study aimed to report clinical features and CT, MRI, PET/CT findings of solid pseudopapillary tumor (SPT) of the pancreas. Thirty-four patients with pathologically proven SPT were retrospectively reviewed. Most patients were asymptomatic. SPTs in male patients mainly appeared as solid and near solid tumors. Mixed tumors and cystic tumors had larger size than solid and near solid tumors. Solid tumors and solid part of mixed tumors were T2 hyperintense and T1 hypointense and had progressive enhancement. Four tumors (80%) showed markedly even or uneven 18 F-FDG uptake...
March 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29072103/posterior-cortical-atrophy-of-a-suspected-non-alzheimer-type-a-case-report
#20
Mark T Wagner, Dana M Szeles, Blakely Mulder, Mimi Sohn, Aljoeson Walker
OBJECTIVE: A case of Posterior Cortical Atrophy syndrome of a suspected non-Alzheimer disease pathology type is presented to illustrate prospective diagnosis and course. METHOD: A 54-year-old woman with vague memory complaints underwent serial neuropsychological assessment, MRI, PET, and CSF screening; data are reviewed. RESULTS: While early diagnosis was confounded by multiple factors, classic visuospatial symptoms were later demonstrated using routine neuropsychological methods...
October 26, 2017: Clinical Neuropsychologist
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