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https://www.readbyqxmd.com/read/28331741/pet-mri-findings-of-two-patients-with-breast-carcinoma-before-treatment
#1
Filiz Çelebi, Ülkühan Köksal, Kezban Nur Pilancı, Çetin Ordu, Dauren Sarsenov, Serkan İlgün, Fatmagül Kuşku Çabuk, Gül Alço, Güzide Özdil, Zeynep Erdoğan, Vahit Özmen
Integrated positron-emission tomography-magnetic resonance imaging (PET-MRI) is a new hybrid simultaneous imaging modality with higher soft tissue contrast and lower radiation doses compared with PET-CT. Two patients who were referred to our hospital with left breast masses that were pathologically diagnosed as invasive ductal carcinoma. The women were then scanned using the first PET-MRI system in Turkey, which was established in our department. In this case report, we aimed to determine the advantages of PET-MRI in staging, follow-up, neoadjuvant chemotherapy response, and to compare the usefulness of this modality with PET-CT and dynamic contrast-enhanced breast MRI...
April 2016: J Breast Health (2013)
https://www.readbyqxmd.com/read/28323929/human-brown-adipose-tissue-temperature-and-fat-fraction-are-related-to-its-metabolic-activity
#2
Kalle Koskensalo, Juho Raiko, Teemu Saari, Virva Saunavaara, Olli Eskola, Pirjo Nuutila, Jani Saunavaara, Riitta Parkkola, Kirsi A Virtanen
Background and aim: The metabolic activity of human brown adipose tissue (BAT) has been previously examined using positron-emission-tomography (PET). The aim of this study was to use proton Magnetic Resonance Spectroscopy (1H MRS) to investigate whether the temperature and the fat fraction (FF) of brown and white adipose tissue (WAT) are associated with BAT metabolic activity determined by 18F-FDG-PET. Materials and methods: Ten healthy subjects (4f/6m, 25-45 y) were studied using PET-MRI during acute cold exposure and at ambient room temperature...
February 21, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28321471/feasibility-of-in-vivo-18-f-florbetaben-pet-mr-imaging-of-human-carotid-amyloid-%C3%AE
#3
Jan Bucerius, Henryk Barthel, Solveig Tiepolt, Peter Werner, Judith C Sluimer, Joachim E Wildberger, Marianne Patt, Swen Hesse, Hermann-Josef Gertz, Erik A L Biessen, Felix M Mottaghy, Osama Sabri
PURPOSE: Amyloid-beta (Aβ) peptides are involved in the inflammatory pathology of atherosclerosis. (18)F-Florbetaben is a PET tracer for clinical imaging of cerebral Aβ plaques in Alzheimer's disease (AD). We sought to determine whether specific uptake of (18)F-florbetaben in the carotid arteries can be identified using a fully integrated hybrid PET/MRI system and whether this uptake is associated with clinical cardiovascular disease (CVD) risk factors. METHODS: Carotid (18)F-florbetaben uptake was quantified as the mean of the maximum target-to-background ratio (meanTBRmax) in 40 cognitively impaired subjects (age 68...
March 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28317152/-68-ga-psma-pet-for-radiation-treatment-planning-in-prostate-cancer-recurrences-after-surgery-individualized-medicine-or-new-standard-in-salvage-treatment
#4
Gregor Habl, Katharina Sauter, Kilian Schiller, Sabrina Dewes, Tobias Maurer, Matthias Eiber, Stephanie E Combs
BACKGROUND: (68) Ga-PSMA-PET imaging is a novel promising diagnostic tool to locate early biochemical failure after radical prostatectomy (RP) in prostate cancer (PC) patients. Exact knowledge of the relapse location may result in changes of the therapy concept aside from changes to the TNM stage. To gain data for this approach, we evaluated PC patients receiving (68) Ga-PSMA-PET imaging before salvage radiotherapy (RT). METHODS AND MATERIALS: In this study, 100 patients with biochemical failure after RP± prior RT who underwent (68) Ga-PSMA PET/CT or PET/MRI were evaluated undergoing salvage RT in our department...
March 20, 2017: Prostate
https://www.readbyqxmd.com/read/28302035/translational-multimodality-neuroimaging
#5
Sushil K Sharma
Recently high-resolution, noninvasive, multimodality in-vivo molecular imaging with PET, SPECT, CT and MRI, employing fusion algorithms has revolutionized personalized medicine. However, specific radiopharmaceuticals (RPs) for the accurate diagnosis and effective treatment of progressive neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, drug addiction, and other cognitive impairments still remain in developmental phase. Currently, multimodality fusion neuroimaging is utilized for the determination of: pharmacokinetics and pre-clinical development of radiopharmaceuticals (RPs); in-vivo monitoring of stem cell transplantation therapy; nicotinic acetylcholine receptors (nAChRs) investigations; and regional cerebral blood flow and glucose metabolism in cognitively-impaired subjects employing noninvasive microPET and nano-SPECT imaging...
March 15, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28290392/potential-for-differentiation-of-glioma-recurrence-from-radionecrosis-using-integrated-18-f-fluoroethyl-l-tyrosine-fet-positron-emission-tomography-magnetic-resonance-imaging-a-prospective-evaluation
#6
Shanti K Sogani, Amarnath Jena, Sangeeta Taneja, Aashish Gambhir, Anil K Mishra, Maria M D'Souza, Sapna M Verma, Puja P Hazari, Pradeep Negi, Ganesh K R Jadhav
PURPOSE: To assess the utility of 18F-fluoroethyl-L-tyrosine (FET) positron emission tomography/magnetic resonance imaging (PET/MRI) in distinguishing recurrence from radionecrosis. MATERIALS AND METHODS: Thirty-two patients (25 males, 7 females) of glioma who had already undergone surgery/chemoradiotherapy and had enhancing brain lesions suspicious of recurrence were evaluated using integrated 18F-FET PET/MRI, and followed up with histopathology or clinical follow-up and/or MRI/PET/MRI imaging...
March 2017: Neurology India
https://www.readbyqxmd.com/read/28289810/non-odontogenic-tumors-of-the-facial-bones-in-children-and-adolescents-role-of-multiparametric-imaging
#7
REVIEW
Minerva Becker, Salvatore Stefanelli, Anne-Laure Rougemont, Pierre Alexandre Poletti, Laura Merlini
Tumors of the pediatric facial skeleton represent a major challenge in clinical practice because they can lead to functional impairment, facial deformation, and long-term disfigurement. Their treatment often requires a multidisciplinary approach, and radiologists play a pivotal role in the diagnosis and management of these lesions. Although rare, pediatric tumors arising in the facial bones comprise a wide spectrum of benign and malignant lesions of osteogenic, fibrogenic, hematopoietic, neurogenic, or epithelial origin...
March 13, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28283354/effect-of-gradient-field-nonlinearity-distortions-in-mri-based-attenuation-maps-for-pet-reconstruction
#8
Josef A Lundman, Adam Johansson, Jörgen Olofsson, Jan Axelsson, Anne Larsson, Tufve Nyholm
PURPOSE: Attenuation correction is a requirement for quantification of the activity distribution in PET. The need to base attenuation correction on MRI instead of CT has arisen with the introduction of integrated PET/MRI systems. The aim was to describe the effect of residual gradient field nonlinearity distortions on PET attenuation correction. METHODS: MRI distortions caused by gradient field nonlinearity were simulated in CT images used for attenuation correction in PET reconstructions...
March 7, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28283219/pet-mri-multiparametric-imaging-of-brain-tumors
#9
Jiří Ferda, Eva Ferdová, Ondřej Hes, Jan Mraček, Boris Kreuzberg, Jan Baxa
A combination of morphological imaging of the brain with microstructural and functional imaging provides a comprehensive overview of the properties of individual tissues. While diffusion weighted imaging provides information about tissue cellularity, spectroscopic imaging allows us to evaluate the integrity of neurons and possible anaerobic glycolysis during tumor hypoxia, in addition to the presence of accelerated synthesis or degradation of cellular membranes; on the other hand, PET metabolic imaging is used to evaluate major metabolic pathways, determining the overall extent of the tumor ((18)F-FET, (18)F-FDOPA, (18)F-FCH) or the degree of differentiation ((18)F-FDG, (18)F-FLT, (18)F-FDOPA and (18)F-FET)...
February 22, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28280965/radiosynthesis-and-first-in-human-pet-mri-evaluation-with-clinical-grade-18-f-ftc-146
#10
Bin Shen, Jun Hyung Park, Trine Hjørnevik, Peter W Cipriano, Daehyun Yoon, Praveen K Gulaka, Dawn Holly, Deepak Behera, Bonnie A Avery, Sanjiv S Gambhir, Christopher R McCurdy, Sandip Biswal, Frederick T Chin
PURPOSE: Sigma-1 receptors (S1Rs) play an important role in many neurological disorders. Simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) with S1R radioligands may provide valuable information for diagnosing and guiding treatment for these diseases. Our previously reported S1R radioligand, [(18)F]FTC-146, demonstrated high affinity for the S1R (K i = 0.0025 nM) and excellent selectivity for the S1R over the sigma-2 receptor (S2Rs; K i = 364 nM) across several species (from mouse to non-human primate)...
March 9, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28274619/pet-mri-of-the-thorax-abdomen-and-retroperitoneum-benefits-of-the-breathing-synchronized-scanning
#11
Jan Baxa, Eva Ferdova, Jiří Ferda
Hybrid imaging using various radiopharmaceuticals is currently essential not only in detection and therapy response monitoring of tumors, but also in assessment of inflammatory or systemic diseases. Combination of positron emission tomography (PET) and magnetic resonance imaging (MRI) is still relatively new method with great prospects of comprehensive assessment using anatomical and multiple functional information. However, benefits of PET/MRI in thorax, abdomen and retroperitoneum are not completely defined...
February 27, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28273651/comparative-preclinical-evaluation-of-68-ga-nodaga-and-68-ga-hbed-cc-conjugated-procainamide-in-melanoma-imaging
#12
György Trencsényi, Noémi Dénes, Gábor Nagy, Adrienn Kis, András Vida, Flóra Farkas, Judit P Szabó, Tünde Kovács, Ervin Berényi, Ildikó Garai, Péter Bai, János Hunyadi, István Kertész
Malignant melanoma is the most aggressive form of skin cancer. The early detection of primary melanoma tumors and metastases using non-invasive PET imaging determines the outcome of this disease. Previous studies have shown that benzamide derivatives (e.g. procainamide) conjugated with PET radionuclides specifically bind to melanin pigment of melanoma tumors. (68)Ga chelating agents can have high influence on physiological properties of (68)Ga labeled bioactive molecules, as was experienced during the application of HBED-CC on PSMA ligand...
March 1, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28267530/evaluation-of-pet-and-mr-datasets-in-integrated-18f-fdg-pet-mri-a-comparison-of-different-mr-sequences-for-whole-body-restaging-of-breast-cancer-patients
#13
Johannes Grueneisen, Lino Morris Sawicki, Axel Wetter, Julian Kirchner, Sonja Kinner, Bahriye Aktas, Michael Forsting, Verena Ruhlmann, Lale Umutlu
OBJECTIVES: To investigate the diagnostic value of different MR sequences and 18F-FDG PET data for whole-body restaging of breast cancer patients utilizing PET/MRI. METHODS: A total of 36 patients with suspected tumor recurrence of breast cancer based on clinical follow-up or abnormal findings in follow-up examinations (e.g. CT, MRI) were prospectively enrolled in this study. All patients underwent a PET/CT and subsequently an additional PET/MR scan. Two readers were instructed to identify the occurrence of a tumor relapse in subsequent MR and PET/MR readings, utilizing different MR sequence constellations for each session...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28262272/pet-mr-imaging-of-pelvic-malignancies
#14
Axel Wetter, Johannes Grueneisen, Lale Umutlu
Integrated PET/MRI is a new technology which allows simultaneous acquisition of positron emission tomography and magnetic resonance imaging data during one examination. The technique appears to be particularly appropriate for oncologic imaging of female and male pelvic malignancies, as these entities demand a high soft tissue contrast and might be further assessed metabolically with PET. The review article highlights recent developments of integrated PET/MRI in pelvic malignancies.
February 20, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28258444/response-assessment-of-bevacizumab-therapy-in-gbm-with-integrated-11c-met-pet-mri-a-feasibility-study
#15
Cornelius Deuschl, Christoph Moenninghoff, Sophia Goericke, Julian Kirchner, Susanne Köppen, Ina Binse, Thorsten D Poeppel, Harald H Quick, Michael Forsting, Lale Umutlu, Ken Herrmann, Joerg Hense, Marc Schlamann
BACKGROUND: The objective of this study was to evaluate the potential of integrated 11C-MET PET/MR for response assessment of relapsed glioblastoma (GBM) receiving bevacizumab treatment. METHODS: Eleven consecutive patients with relapsed GBM were enrolled for an integrated 11C-MET PET/MRI at baseline and at follow-up. Treatment response for MRI was evaluated according to Response Assessment in Neuro-oncology (RANO) criteria and integrated 11C-MET PET was assessed by the T/N ratio...
March 3, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28258126/effects-of-meal-and-incretins-in-the-regulation-of-splanchnic-blood-flow
#16
Jukka Koffert, Henri Honka, Jarmo Teuho, Saila Kauhanen, Saija Hurme, Riitta Parkkola, Vesa Oikonen, Andrea Mari, Andreas Lindqvist, Nils Wierup, Leif Groop, Pirjo Nuutila
OBJECTIVE: Meal ingestion is followed by a redistribution of blood flow (BF) within the splanchnic region contributing to nutrient absorption, insulin secretion and glucose disposal, but factors regulating this phenomenon in humans are poorly known. The aim of the present study was to evaluate the organ-specific changes in BF during a mixed-meal and incretin infusions. DESIGN: Non-randomized intervention study of 10 healthy adults to study splanchnic BF regulation...
March 3, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28258057/psoriasis-as-a-human-model-of-disease-to-study-inflammatory-atherogenesis
#17
Charlotte L Harrington, Amit K Dey, Raza Yunus, Aditya A Joshi, Nehal N Mehta
Inflammation is known to play a significant role in the process of atherogenesis and cardiovascular disease (CVD). Indeed, patients with chronic inflammatory diseases are at increased risk for cardiovascular events. The mechanisms linking chronic inflammation and CVD however remain poorly understood. Psoriasis, a chronic inflammatory skin disease associated with a greater risk of early cardiovascular events, provides a suitable human model to study the pathophysiology of inflammatory atherogenesis in humans...
March 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28256615/associations-between-tumor-vascularity-vascular-endothelial-growth-factor-expression-and-pet-mri-radiomic-signatures-in-primary-clear-cell-renal-cell-carcinoma-proof-of-concept-study
#18
Qingbo Yin, Sheng-Che Hung, Li Wang, Weili Lin, Julia R Fielding, W Kimryn Rathmell, Amir H Khandani, Michael E Woods, Matthew I Milowsky, Samira A Brooks, Eric M Wallen, Dinggang Shen
Studies have shown that tumor angiogenesis is an essential process for tumor growth, proliferation and metastasis. Also, tumor angiogenesis is an important prognostic factor of clear cell renal cell carcinoma (ccRCC), as well as a factor in guiding treatment with antiangiogenic agents. Here, we attempted to find the associations between tumor angiogenesis and radiomic imaging features from PET/MRI. Specifically, sparse canonical correlation analysis was conducted on 3 feature datasets (i.e., radiomic imaging features, tumor microvascular density (MVD), and vascular endothelial growth factor (VEGF) expression) from 9 patients with primary ccRCC...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28254872/pet-mri-for-oncological-brain-imaging-a-comparison-of-standard-mr-based-attenuation-corrections-with-a-novel-model-based-approach-for-the-siemens-mmr-pet-mr-system
#19
Ivo Rausch, Lucas Rischka, Claes N Ladefoged, Julia Furtner, Matthias Fenchel, Andreas Hahn, Rupert Lanzenberger, Marius E Mayerhoefer, Tatjana Traub-Weidinger, Thomas Beyer
To compare attenuation correction (AC) approaches for positron emission tomography/magnetic resonance imaging (PET/MRI) in clinical neuro-oncology. Methods: Forty-nine PET/MRI brain scans were included: brain tumor studies using (18)F-FET (n = 31) and 68-Ga-DOTANOC (n = 7) and studies of healthy subjects using (18)F-FDG (n = 11). For each subject, MR-based AC maps (MR-AC) were acquired using the standard DIXON- (DIXON) and UTE-based (UTE) approaches. A third MR-AC was calculated using a model-based, post-processing approach to account for bone attenuation values (BD, non-commercial prototype software by Siemens Healthcare)...
March 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28252525/comparative-characteristics-of-quantitative-indexes-for-18f-fdg-uptake-and-metabolic-volume-in-sequentially-obtained-pet-mri-and-pet-ct
#20
COMPARATIVE STUDY
Soo Jin Lee, Jin Chul Paeng, Jin Mo Goo, Jeong Min Lee, Gi Jeong Cheon, Dong Soo Lee, June-Key Chung, Keon Wook Kang
PURPOSE: The purpose of this study was to compare quantitative indexes for fluorine-18 fluorodeoxyglucose uptake and metabolic volume between PET/MRI and PET/CT. PATIENTS AND METHODS: Sixty-six patients with solid tumors (32 with lung cancer and 34 with pancreatic cancer) who underwent sequential fluorine-18 fluorodeoxyglucose PET/MRI and PET/CT were retrospectively enrolled. On PET images, maximum and peak standardized uptake values (SUVmax and SUVpeak, respectively), and maximum tumor-to-liver ratio (TLRmax) were measured...
April 2017: Nuclear Medicine Communications
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