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https://www.readbyqxmd.com/read/28641952/the-effect-of-tissue-segmented-attenuation-maps-on-pet-quantification-with-a-special-focus-on-large-arteries
#1
A Mota-Cobian, J C Alonso-Farto, L Fernández-Friera, J Sánchez-González, B López-Melgar, L J Jiménez-Borreguero, V Fuster, J Ruiz-Cabello, S España
OBJECTIVES: Accuracy on quantitative PET image analysis relies on the correct application of attenuation correction which is one of the major challenges for PET/MRI that remains to be solved. The purpose of this study is to evaluate the effect of MRI-based attenuation maps and the use of flexible coils on the quantitative accuracy of PET images with a special focus on large arteries. MATERIALS AND METHODS: PET/CT data from eight oncologic patients was used. PET data was reconstructed using attenuation maps with different level of detail emulating several approaches available on current PET/MRI scanners...
June 19, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28640521/pet-mri-for-evaluating-subclinical-inflammation-of-ulcerative-colitis
#2
I-Lun Shih, Shu-Chen Wei, Rouh-Fang Yen, Chin-Chen Chang, Chi-Lun Ko, Been-Ren Lin, Chia-Tung Shun, Kao-Lang Liu, Jau-Min Wong, Yeun-Chung Chang
PURPOSE: To explore the utility of integrated positron emission tomography (PET) / magnetic resonance imaging (MRI) for evaluating subclinical inflammation in patients with ulcerative colitis (UC). MATERIALS AND METHODS: This prospective study was approved by the Institutional Review Board and informed consent was obtained. Between November 2015 and April 2016, 19 consecutive patients with UC in clinical remission were enrolled. These patients underwent 18F-fluorodeoxyglucose PET/MRI (3T) and colonoscopy...
June 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28631080/comparison-of-volumetric-and-functional-parameters-in-simultaneous-cardiac-pet-mr-feasibility-of-volumetric-assessment-with-residual-activity-from-prior-pet-ct
#3
C Lücke, B Oppolzer, P Werner, B Foldyna, P Lurz, T Jochimsen, B Brenneis, L Lehmkuhl, B Sattler, M Grothoff, H Barthel, O Sabri, M Gutberlet
OBJECTIVE: To compare cardiac left ventricular (LV) parameters in simultaneously acquired hybrid fluorine-18-fluorodeoxyglucose ([18F] FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) in patients with residual tracer activity of upstream PET/CT. METHODS: Twenty-nine patients (23 men, age 58±17 years) underwent cardiac PET/MRI either directly after a non-cardiac PET/CT with homogenous cardiac [18F] FDG uptake (n=20) or for viability assessment (n=9)...
June 19, 2017: European Radiology
https://www.readbyqxmd.com/read/28625749/preclinical-evaluation-of-melanocortin-1-receptor-mc1-r-specific-68-ga-and-44-sc-labeled-dota-napamide-in-melanoma-imaging
#4
Gábor Nagy, Noémi Dénes, Adrienn Kis, Judit P Szabó, Ervin Berényi, Ildikó Garai, Péter Bai, István Hajdu, Dezső Szikra, György Trencsényi
PURPOSE: Alpha melanocyte stimulating hormone (α-MSH) enhances melanogenesis in melanoma malignum by binding to melanocortin-1 receptors (MC1-R). Earlier studies demonstrated that alpha-MSH analog NAPamide molecule specifically binds to MC1-R receptor. Radiolabeled NAPamide is a promising radiotracer for the non-invasive detection of melanin producing melanoma tumors by Positron Emission Tomography (PET). In this present study the MC1-R selectivity of the newly developed Sc-44-labeled DOTA-NAPamide was investigated in vitro and in vivo using melanoma tumors...
June 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28624017/association-of-pharmacokinetic-and-metabolic-parameters-derived-using-simultaneous-pet-mri-initial-findings-and-impact-on-response-evaluation-in-breast-cancer
#5
Amarnath Jena, Sangeeta Taneja, Aru Singh, Pradeep Negi, Shashi Bhushan Mehta, Aashim Ahuja, Manish Singhal, Ramesh Sarin
PURPOSE: To study relationships among pharmacokinetic and (18)F-fluorodeoxyglucose ((18)F-FDG) PET parameters obtained through simultaneous PET/MRI in breast cancer patients and evaluate their combined potential for response evaluation. METHODS: The study included 41 breast cancer patients for correlation study and 9 patients (pre and post therapy) for response evaluation. All patients underwent simultaneous PET/MRI with dedicated breast imaging. Pharmacokinetic parameters and PET parameters for tumor were derived using an in- house developed and vendor provided softwares respectively...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28622420/technical-note-comparison-of-megavoltage-dual-energy-and-single-energy-ct-based-%C3%AE-maps-for-a-4-channel-breast-coil-in-pet-mri
#6
John C Patrick, R Terry Thompson, Aaron So, John Butler, David Faul, Robert Z Stodilka, Slav Yartsev, Frank S Prato, Stewart Gaede
PURPOSE: The purpose of this study was to describe and evaluate methods for calculating a megavoltage computed tomography (MVCT) derived MR hardware attenuation map (μ-map) and dual-energy CT (DECT) for 511 keV photons. METHODS: Phantom measurements were acquired on a whole-body hybrid PET/MRI system, using a four-channel receive-only MR radiofrequency (RF) breast coil. Two acquisitions were performed: with the phantoms positioned in the four-channel RF breast coil, and without the breast coil...
June 16, 2017: Medical Physics
https://www.readbyqxmd.com/read/28621567/-68-ga-radiolabeled-aguix-nanoparticles-as-dual-modality-imaging-agents-for-pet-mri-guided-radiation-therapy
#7
Penelope Bouziotis, Dimitris Stellas, Eloïse Thomas, Charles Truillet, Charalampos Tsoukalas, François Lux, Theodoros Tsotakos, Stavros Xanthopoulos, Maria Paravatou-Petsotas, Anastasios Gaitanis, Lia Angela Moulopoulos, Vassilis Koutoulidis, Constantinos D Anagnostopoulos, Olivier Tillement
AIM: The aim of this study was to develop a dual-modality positron emission tomography/magnetic resonance (PET/MR) imaging probe by radiolabeling gadolinium-containing AGuIX derivatives with the positron-emitter Gallium-68 ((68)Ga). MATERIALS & METHODS: AGuIX@NODAGA nanoparticles were labeled with (68)Ga at high efficiency. Tumor accumulation in an appropriate disease model was assessed by ex vivo biodistribution and in vivo PET/MR imaging. RESULTS:  (68)Ga-AGuIX@NODAGA was proven to passively accumulate in U87MG human glioblastoma tumor xenografts...
June 16, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28608163/prostate-specific-membrane-antigen-pet-mri-validation-of-mr-textural-analysis-for-detection-of-transition-zone-prostate-cancer
#8
Anthony Bates, Kenneth Miles
OBJECTIVES: To validate MR textural analysis (MRTA) for detection of transition zone (TZ) prostate cancer through comparison with co-registered prostate-specific membrane antigen (PSMA) PET-MR. METHODS: Retrospective analysis was performed for 30 men who underwent simultaneous PSMA PET-MR imaging for staging of prostate cancer. Thirty texture features were derived from each manually contoured T2-weighted, transaxial, prostatic TZ using texture analysis software that applies a spatial band-pass filter and quantifies texture through histogram analysis...
June 12, 2017: European Radiology
https://www.readbyqxmd.com/read/28604476/pet-mr-in-the-assessment-of-pediatric-histiocytoses-a-comparison-to-pet-ct
#9
Andrew C Sher, Robert Orth, Kenneth McClain, Carl Allen, Shireen Hayatghaibi, Victor Seghers
PURPOSE: The aim of this study was to analyze the feasibility and diagnostic performance of F-FDG PET/MR compared with F-FDG PET/CT in a cohort of pediatric histiocytosis patients with regard to image quality, lesion detection, and FDG quantification. METHODS: Children with a diagnosis of Langerhans cell histiocytosis or Rosai-Dorfman disease were prospectively recruited. Seventeen PET/CT and PET/MR examinations were performed on 9 patients (mean age, 6.2 years) following a single-injection dual-imaging protocol...
June 9, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28600647/hybrid-18-f-fdg-pet-mri-might-improve-locoregional-staging-of-breast-cancer-patients-prior-to-neoadjuvant-chemotherapy
#10
Briete Goorts, Stefan Vöö, Thiemo J A van Nijnatten, Loes F S Kooreman, Maaike de Boer, Kristien B M I Keymeulen, Romy Aarnoutse, Joachim E Wildberger, Felix M Mottaghy, Marc B I Lobbes, Marjolein L Smidt
PURPOSE: Our purpose in this study was to assess the added clinical value of hybrid (18)F-FDG-PET/MRI compared to conventional imaging for locoregional staging in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). METHODS: In this prospective study, primary invasive cT2-4 N0 or cT1-4 N+ breast cancer patients undergoing NAC were included. A PET/MRI breast protocol was performed before treatment. MR images were evaluated by a breast radiologist, blinded for PET images...
June 10, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28585030/assessment-of-myocardial-viability-of-a-patient-with-old-myocardial-infarction-by-18-f-fluorodeoxyglucose-pet-mri
#11
Atsuro Masuda, Ayaka Nemoto, Takayoshi Yamaki, Noboru Oriuchi, Seiichi Takenoshita, Yasuchika Takeishi
No abstract text is available yet for this article.
June 5, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28583279/pet-in-benign-bone-marrow-disorders
#12
REVIEW
Wouter van der Bruggen, Andor W J M Glaudemans, Edo Vellenga, Riemer H J A Slart
This review aims to describe the current status of benign bone marrow (BM) imaging using PET. BM imaging is important as the BM is not only involved in poiesis of different vital cell lines and can be affected by primary BM disorders, but it is also frequently affected by several extramedullary diseases. Indications for the use of PET in benign BM disorders are the detection of extramedullary hematopoiesis, evaluation of patients with a discrepancy between BM histology and clinical status, visualizing BM infarctions, location of the optimal site for BM biopsy, diagnosing and staging of other hematological BM disorders, evaluation of radiotherapy effect on BM, and evaluation of BM transplantation...
July 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28578690/evaluation-of-treatment-response-and-resistance-in-metastatic-renal-cell-cancer-mrcc-using-integrated-18-f-fluorodeoxyglucose-18-f-fdg-positron-emission-tomography-magnetic-resonance-imaging-pet-mri-the-remap-study
#13
Christian Kelly-Morland, Sarah Rudman, Paul Nathan, Susan Mallett, Giovanni Montana, Gary Cook, Vicky Goh
BACKGROUND: Tyrosine kinase inhibitors are the first line standard of care for treatment of metastatic renal cell carcinoma (RCC). Accurate response assessment in the setting of antiangiogenic therapies remains suboptimal as standard size-related response criteria do not necessarily accurately reflect clinical benefit, as they may be less pronounced or occur later in therapy than devascularisation. The challenge for imaging is providing timely assessment of disease status allowing therapies to be tailored to ensure ongoing clinical benefit...
June 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28575696/regiospecific-radiolabelling-of-nanofitin-on-ni-magnetic-beads-with-18-f-fbem-and-in-vivo-pet-studies
#14
Sylvestre Dammicco, Marine Goux, Christian Lemaire, Guillaume Becker, Mohamed Ali Bahri, Alain Plenevaux, Mathieu Cinier, André Luxen
INTRODUCTION: Nanofitins are low molecular weight, single chain and cysteine-free protein scaffolds able to selectively bind a defined biological target. They derive from Sac7d bacterial protein family and are highly stable over a wide range of pH (0-13) and temperature (Tm ~80°C). Their extreme stability, low cost of production and high tolerability for chemical coupling make Nanofitins a very interesting alternative to antibodies and their fragments. Here, a hexahistidine tagged model Nanofitin (H4) directed against hen egg white lysozyme was radiolabelled and injected in mice to provide a baseline biodistribution and pharmacokinetic profiles to support future Nanofitin development programs...
April 27, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28572487/biodistribution-and-radiation-dosimetry-of-18-f-ftc-146-in-humans
#15
Trine Hjørnevik, Peter W Cipriano, Bin Shen, Jun Hyung Park, Praveen Gulaka, Dawn Holley, Harsh Gandhi, Daehyun Yoon, Erik S Mittra, Greg Zaharchuk, Sanjiv S Gambhir, Christopher R McCurdy, Frederick T Chin, Sandip Biswal
The purpose of this study is to assess safety, biodistribution and radiation dosimetry in humans for the highly selective sigma-1 receptor (S1R) positron emission tomography (PET) agent (18)F-6-(3-fluoropropyl)-3-(2-(azepan-1-yl)ethyl)benzo[d]thiazol-2(3H)-one ((18)F-FTC-146). Methods: Ten healthy volunteers (HV; five female, five male; age: 34.3 ± 6.5 years) were recruited, and written informed consent was obtained from all participants. Series of whole-body PET/magnetic resonance imaging (PET/MRI) examinations were acquired for up to three hours after injection (357...
June 1, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28569617/multimodal-partial-volume-correction-application-to-11-c-pib-pet-mri-myelin-imaging-in-multiple-sclerosis
#16
Elisabetta Grecchi, Mattia Veronese, Benedetta Bodini, Daniel García-Lorenzo, Marco Battaglini, Bruno Stankoff, Federico E Turkheimer
The [(11)C]PIB PET tracer, originally developed for amyloid imaging, has been recently repurposed to quantify demyelination and remyelination in multiple sclerosis (MS). Myelin PET imaging, however, is limited by its low resolution that deteriorates the quantification accuracy of white matter (WM) lesions. Here, we introduce a novel partial volume correction (PVC) method called Multiresolution-Multimodal Resolution-Recovery (MM-RR), which uses the wavelet transform and a synergistic statistical model to exploit MRI structural images to improve the resolution of [(11)C]PIB PET myelin imaging...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28567495/integrated-18f-fdg-pet-mri-compared-to-mri-alone-for-identification-of-local-recurrences-of-soft-tissue-sarcomas-a-comparison-trial
#17
Youssef Erfanian, Johannes Grueneisen, Julian Kirchner, Axel Wetter, Lars Erik Podleska, Sebastian Bauer, Thorsten Poeppel, Michael Forsting, Ken Herrmann, Lale Umutlu
PURPOSE: To assess and compare the diagnostic accuracy of PET/MRI and MRI alone for the detection of local recurrences of soft tissue sarcomas (STS) after initial surgical resection of the primary tumors. MATERIAL AND METHODS: A total of 41 patients with clinically suspected tumor relapse of STS underwent an (18)F-FDG-PET/MRI examination for assessment of local recurrence. Two experienced physicians interpreted the MRI data and subsequently the PET/MRI datasets in two separate reading sessions and were instructed to identify potential local tumor recurrences...
May 31, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28567001/time-to-amyloid-positivity-and-preclinical-changes-in-brain-metabolism-atrophy-and-cognition-evidence-for-emerging-amyloid-pathology-in-alzheimer-s-disease
#18
Philip S Insel, Rik Ossenkoppele, Devon Gessert, William Jagust, Susan Landau, Oskar Hansson, Michael W Weiner, Niklas Mattsson
Background: Aβ pathology is associated with longitudinal changes of brain metabolism, atrophy, and cognition, in cognitively healthy elders. However, Aβ information is usually measured cross-sectionally and dichotomized to classify subjects as Aβ-positive or Aβ-negative, making it difficult to evaluate when brain and cognitive changes occur with respect to emerging Aβ pathology. In this study, we use longitudinal Aβ information to combine the level and rate of change of Aβ to estimate the time to Aβ-positivity for each subject and test this temporal proximity to significant Aβ pathology for associations with brain structure, metabolism, and cognition...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28559006/acl-graft-metabolic-activity-assessed-by-18-fdg-pet-mri
#19
Robert A Magnussen, Katherine Binzel, Jun Zhang, Wenbo Wei, Melanie U Knopp, David C Flanigan, Timothy E Hewett, Christopher C Kaeding, Michael V Knopp
BACKGROUND: To demonstrate the use of (18)Fluorodeoxyglucose positron emission tomography (PET) and magnetic resonance imaging (MRI) in combination ((18)FDG-PET) to assess the metabolic activity of ACL graft tissue and evaluate the utility of this technique for ligament imaging. METHODS: Twenty-one knees with intact ACL grafts in 19 patients at multiple time points following ACL reconstruction were recruited to participate. PET-MRI imaging was performed using a custom device to place knees in the same position for both studies...
May 27, 2017: Knee
https://www.readbyqxmd.com/read/28557202/gastrointestinal-multiparametric-hybrid-18-fdg-pet-mri-evaluation-of-gastric-adenocarcinoma
#20
S M Broski, G B Johnson, A H Goenka
No abstract text is available yet for this article.
June 2017: Journal of Gastroenterology and Hepatology
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