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https://www.readbyqxmd.com/read/28723938/gender-differences-in-cerebral-metabolism-for-color-processing-in-mice-a-pet-mri-study
#1
Philip C Njemanze, Mathias Kranz, Mario Amend, Jens Hauser, Hans Wehrl, Peter Brust
INTRODUCTION: Color processing is a central component of mammalian vision. Gender-related differences of color processing revealed by non-invasive functional transcranial Doppler ultrasound suggested right hemisphere pattern for blue/yellow chromatic opponency by men, and a left hemisphere pattern by women. MATERIALS AND METHODS: The present study measured the accumulation of [18F]fluorodeoxyglucose ([18F]FDG) in mouse brain using small animal positron emission tomography and magnetic resonance imaging (PET/MRI) with statistical parametric mapping (SPM) during light stimulation with blue and yellow filters compared to darkness condition...
2017: PloS One
https://www.readbyqxmd.com/read/28719629/multiparametric-11c-acetate-positron-emission-tomography-magnetic-resonance-imaging-in-the-assessment-and-staging-of-prostate-cancer
#2
Stephan H Polanec, Piotr Andrzejewski, Pascal A T Baltzer, Thomas H Helbich, Alexander Stiglbauer, Dietmar Georg, Georgios Karanikas, Martin Susani, Wolfgang Wadsak, Markus Margreiter, Markus Mitterhauser, Peter Brader, Katja Pinker
BACKGROUND: The aim of this study was to evaluate whether MP [11C]Acetate PET-MRI enables an accurate differentiation of benign and malignant prostate tumors as well as local and distant staging. MATERIALS AND METHODS: Fifty-six consecutive patients fulfilling the following criteria were included in this IRB-approved prospective study: elevated PSA levels or suspicious findings at digital rectal examination or TRUS; and histopathological verification. All patients underwent MP [11C]Acetate PET-MRI of the prostate performed on separate scanners with PET/CT using [11C]Acetate and 3T MP MR imaging...
2017: PloS One
https://www.readbyqxmd.com/read/28718993/role-of-fdg-pet-mri-fdg-pet-ct-and-dynamic-susceptibility-contrast-perfusion-mri-in-differentiating-radiation-necrosis-from-tumor-recurrence-in-glioblastomas
#3
Mojgan Hojjati, Chaitra Badve, Vasant Garg, Curtis Tatsuoka, Lisa Rogers, Andrew Sloan, Peter Faulhaber, Pablo R Ros, Leo J Wolansky
BACKGROUND AND PURPOSE: To compare the utility of quantitative PET/MRI, dynamic susceptibility contrast (DSC) perfusion MRI (pMRI), and PET/CT in differentiating radiation necrosis (RN) from tumor recurrence (TR) in patients with treated glioblastoma multiforme (GBM). METHODS: The study included 24 patients with GBM treated with surgery, radiotherapy, and temozolomide who presented with progression on imaging follow-up. All patients underwent PET/MRI and pMRI during a single examination...
July 18, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28718074/advances-in-imaging-instrumentation-for-nuclear-cardiology
#4
Jae Sung Lee, Gil Kovalski, Tali Sharir, Dong Soo Lee
Advances in imaging instrumentation and technology have greatly contributed to nuclear cardiology. Dedicated cardiac SPECT cameras incorporating novel, highly efficient detector, collimator, and system designs have emerged with the expansion of nuclear cardiology. Solid-state radiation detectors incorporating cadmium zinc telluride, which directly convert radiation to electrical signals and yield improved energy resolution and spatial resolution and enhanced count sensitivity geometries, are increasingly gaining favor as the detector of choice for application in dedicated cardiac SPECT systems...
July 17, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28716214/early-68-ga-psma-pet-mri-acquisition-assessment-of-lesion-detectability-and-pet-metrics-in-patients-with-prostate-cancer-undergoing-same-day-late-pet-ct
#5
L Domachevsky, H Bernstine, N Goldberg, M Nidam, D Stern, J Sosna, D Groshar
AIM: To compare lesion detectability and positron-emission tomography (PET) metric measurements between early-PET/magnetic resonance imaging (MRI) acquisition and same-day PET/computed tomography (CT). MATERIALS AND METHODS: The study was approved by the institutional review board and written informed consent was obtained from all patients. Twenty-one patients underwent non-time-of-flight (TOF) PET/MRI immediately following (68)GA-prostate-specific membrane antigen (PSMA) tracer injection in two steps: firstly, early prostate PET/MRI (pPET/MRI) and early whole-body (WB) PET/MRI (wbPET/MR) followed by WB TOF PET/CT (wbPET/CT)...
July 14, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28715042/-diagnostic-significance-of-multiparametric-mri-combined-with-us-fusion-guided-biopsy-of-the-prostate-in-patients-with-increased-psa-levels-and-negative-standard-biopsy-results-to-detect-significant-prostate-cancer-correlation-with-the-gleason-score-korrelation
#6
Manuela Hoffmann, Manuela A Hoffmann, Helmut J Wieler, Frank M Jakobs, Kasra Taymoorian, Arnd Gerhards, Matthias Miederer, Mathias Schreckenberger
AIMS: To increase diagnostic precision and to reduce overtreatment of low-risk malignant disease, multiparametric MRI (mpMRI) combined with ultrasound (US) fusion guided biopsy of the prostate were performed. METHODS: In 99 male patients with increased PSA plasma levels and previous negative standard biopsy procedures, mpMRI was carried out followed by US fusion guided perineal biopsy. PI-RADS-Data (PS) of mpMRI and histopathological Gleason score (GS) were categorized and statistically compared...
July 17, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28707543/pet-mri-knocking-on-the-doors-of-the-rich-and-famous
#7
Thomas Beyer, Marcus Hacker, Vicky Goh
Since 2010 the portfolio of PET-based imaging has been expanded by industry with the introduction of combined whole-body PET/MRI systems with the intent of merging PET-based molecular imaging with the strengths of MRI. PET/MRI has created a lot of hype in the scientific community but comparatively little traction in the clinic. The first years of whole-body PET/MRI were used to address inherent technical challenges, however, it is now time to make use of the full potential of this integrated imaging modality...
July 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28704342/a-novel-compact-small-field-of-view-hybrid-gamma-camera-first-clinical-results
#8
Aik H Ng, Patricia E Blackshaw, Mohammed S Alqahtani, Layal K Jambi, Sarah L Bugby, John E Lees, Alan C Perkins
INTRODUCTION: Hybrid imaging has proven to be a major innovation in nuclear medicine, allowing the fusion of functional information with anatomical detail. In the past, the use of hybrid imaging such as PET-CT, PET-MRI and SPECT-CT has been of great clinical benefit; however, these scanners are relatively large and bulky. We have developed and investigated the clinical application of a compact small field of view hybrid gamma camera (HGC) that is suitable for small-organ imaging at the patient bedside...
July 12, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28695243/cns-metabolism-in-high-risk-drug-abuse-insights-gained-from-1-h-31-p-mrs-and-pet
#9
REVIEW
S Bodea
BACKGROUND: High-risk drug consumption is a matter of great concern for public health actors in industrialised countries. The latest trends show a market tendency towards diversification and increasing demand for high-purity synthetic drugs. While most consumers seek medical help after cannabis use, it is high-risk drugs like cocaine, heroin and amphetamines that account for most of the 1000 drug-related deaths that occur in Germany every year. PURPOSE: This article presents the most prominent in vivo cerebral metabolic information in cocaine, heroin and methamphetamine users provided by MRI spectroscopy and PET imaging...
July 10, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28689221/variable-refocusing-flip-angle-single-shot-fast-spin-echo-imaging-of-liver-lesions-increased-speed-and-lesion-contrast
#10
Robert M Hicks, Andreas M Loening, Michael A Ohliger, Shreyas S Vasanawala, Thomas A Hope
PURPOSE: To evaluate acquisition time and clinical image quality of a variable refocusing flip angle (vrf) single-shot fast spin echo (SSFSE) sequence in comparison with a conventional SSFSE sequence for imaging of liver lesions in patients undergoing whole-body PET/MRI for oncologic staging. METHODS: A vrfSSFSE sequence was acquired in 43 patients with known pancreatic neuroendocrine tumors undergoing (68)Ga-DOTA-TOC PET on a simultaneous time-of-flight 3.0T PET/MRI...
July 8, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28688023/-pet-ct-and-pet-mri-of-the-prostate-from-18-f-fdg-to-68-ga-psma
#11
REVIEW
K Knorr, M Eiber, T Maurer, H-J Wester, K Scheidhauer
CLINICAL/METHODICAL ISSUE: In the last few years nuclear medical diagnostics have experienced a unprecedented renaissance in the diagnostics of prostate cancer, due to the availability of hybrid imaging with positron emission tomography computed tomography (PET/CT), PET magnetic resonance imaging (PET/MRI) and single photon emission computed tomography (SPECT) CT as well as the development of prostate-specific radiopharmaceuticals. METHODICAL INNOVATIONS: The use of fluorodeoxyglucose (FDG), which has been successfully implemented for many years in PET diagnostics, is only helpful in dedifferentiated tumors due to the biological characteristics of prostate cancer...
July 7, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28684867/combined-magnetomotive-ultrasound-pet-ct-and-mr-imaging-of-68-ga-labelled-superparamagnetic-iron-oxide-nanoparticles-in-rat-sentinel-lymph-nodes-in-vivo
#12
Maria Evertsson, Pontus Kjellman, Magnus Cinthio, Roger Andersson, Thuy A Tran, Rene In't Zandt, Gustav Grafström, Hanna Toftevall, Sarah Fredriksson, Christian Ingvar, Sven-Erik Strand, Tomas Jansson
Current methods for intra-surgical guidance to localize metastases at cancer surgery are based on radioactive tracers that cause logistical challenges. We propose the use of a novel ultrasound-based method, magnetomotive ultrasound (MMUS) imaging that employ a nanoparticle-based contrast agent that also may be used for pre-operative PET/MRI imaging. Since MMUS is radiation free, this eliminates the dependence between pre- and intra-operative imaging and the radiation exposure for the surgical staff. This study investigates a hypothetical clinical scenario of pre-operative PET imaging, combined with intra-operative MMUS imaging, implemented in a sentinel lymph node (SLN) rat model...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28683109/18-f-fdg-pet-mr-imaging-in-patients-with-suspected-liver-lesions-value-of-liver-specific-contrast-agent-gadobenate-dimeglumine
#13
Julian Kirchner, Lino M Sawicki, Cornelius Deuschl, Johannes Grüneisen, Karsten Beiderwellen, Thomas C Lauenstein, Ken Herrmann, Michael Forsting, Philipp Heusch, Lale Umutlu
OBJECTIVES: To evaluate the added value of the application of the liver-specific contrast phase of Gadobenate dimeglumine (Gd-BOPTA) for detection and characterization of liver lesions in 18F-FDG PET/MRI. METHODS: 41 patients with histologically confirmed solid tumors and known / suspected liver metastases or not classifiable lesions in 18F-FDG PET/CT were included in this study. All patients underwent a subsequent Gd-BOPTA enhanced 18F-FDG PET/MRI examination. MRI without liver-specific contrast phase (MRI1), MRI with liver-specific contrast phase (MRI2), 18F-FDG PET/MRI without liver-specific contrast phase (PET/MRI1) and with liver-specific contrast phase (PET/MRI2) were separately evaluated for suspect lesions regarding lesion dignity, characterization, conspicuity and confidence...
2017: PloS One
https://www.readbyqxmd.com/read/28682844/whole-body-68ga-dotanoc-pet-mri-versus-68ga-dotanoc-pet-ct-in-patients-with-neuroendocrine-tumors-a-prospective-study-in-28-patients
#14
Dominik Berzaczy, Chiara Giraudo, Alexander R Haug, Markus Raderer, Daniela Senn, Georgios Karanikas, Michael Weber, Marius E Mayerhoefer
PURPOSE: The aim of this study was to assess the diagnostic performance of simultaneous whole-body Ga-DOTANOC PET/MRI compared with Ga-DOTANOC PET/CT for detection of distant metastatic disease in patients with well-differentiated neuroendocrine tumors (NETs). METHODS: Patients with histologically proven, well-differentiated NET (G1 or G2) were included in this prospective, institutional review board-approved study. Patients underwent Ga-DOTANOC PET/CT and subsequent Ga-DOTANOC PET/MRI after a single tracer injection on the same day for staging or restaging purposes...
July 6, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28678576/reliability-of-18-f-fdg-pet-metabolic-parameters-derived-using-simultaneous-pet-mri-and-correlation-with-prognostic-factors-of-invasive-ductal-carcinoma-a-feasibility-study
#15
Amarnath Jena, Sangeeta Taneja, Aru Singh, Pradeep Negi, Ramesh Sarin, Pratap K Das, Manish Singhal
OBJECTIVE: The objective of our study was to correlate semiquantitative PET parameters-standardized uptake value (SUV) and total lesion glycolysis (TLG)-derived in simultaneous PET/MRI using MRI-based attenuation correction with clinical and histopathologic prognostic factors in patients with breast cancer. MATERIALS AND METHODS: Eighty-two invasive ductal carcinomas in 69 women were included in the study. All the subjects underwent whole-body (WB) PET/MRI (supine WB mode) and dedicated PET/MRI of the breast (prone breast imaging mode) for staging on a simultaneous PET/MRI system...
July 5, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28675208/novel-bifunctional-data-chelator-for-quick-access-to-site-directed-pet-68-ga-radiotracers-preclinical-proof-of-principle-with-tyr-3-octreotide
#16
Berthold A Nock, Aikaterini Kaloudi, Johannes Nagel, Jean-Philippe Sinnes, Frank Roesch, Theodosia Maina
Molecular imaging of tumors with the PET radionuclide (68)Ga has gained momentum in clinical oncology due to the expanding availability of commercial (68)Ge/(68)Ga-generators in combination with state-of-the-art PET/CT and PET/MRI hybrid imaging systems. Concurrently, interesting peptide-based or small-size vectors have been developed for theranostic use in cancer patients. Owing to the short half-life of (68)Ga (t1/2 = 67.7 min) and the sensitivity of many targeting biomolecules, labeling and kit reconstitution in mild conditions allowing for quick access to ready-for-injection PET-tracers are highly desirable...
July 4, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28674847/a-new-integrated-dual-time-point-amyloid-pet-mri-data-analysis-method
#17
Diego Cecchin, Henryk Barthel, Davide Poggiali, Annachiara Cagnin, Solveig Tiepolt, Pietro Zucchetta, Paolo Turco, Paolo Gallo, Anna Chiara Frigo, Osama Sabri, Franco Bui
PURPOSE: In the initial evaluation of patients with suspected dementia and Alzheimer's disease, there is no consensus on how to perform semiquantification of amyloid in such a way that it: (1) facilitates visual qualitative interpretation, (2) takes the kinetic behaviour of the tracer into consideration particularly with regard to at least partially correcting for blood flow dependence, (3) analyses the amyloid load based on accurate parcellation of cortical and subcortical areas, (4) includes partial volume effect correction (PVEC), (5) includes MRI-derived topographical indexes, (6) enables application to PET/MRI images and PET/CT images with separately acquired MR images, and (7) allows automation...
July 4, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28672016/quantitative-assessment-of-simultaneous-f-18-fdg-pet-mri-in-patients-with-various-types-of-hepatic-tumors-correlation-between-glucose-metabolism-and-apparent-diffusion-coefficient
#18
Eunjung Kong, Kyung Ah Chun, Ihn Ho Cho
PURPOSE: Metabolism and water diffusion may have a relationship or an effect on each other in the same tumor. Knowledge of their relationship could expand the understanding of tumor biology and serve the field of oncologic imaging. This study aimed to evaluate the relationship between metabolism and water diffusivity in hepatic tumors using a simultaneous positron emission tomography/magnetic resonance imaging (PET/MRI) system with F-18 fluorodeoxyglucose (FDG) and to reveal the metabolic and diffusional characteristics of each type of hepatic tumor...
2017: PloS One
https://www.readbyqxmd.com/read/28670174/systematic-review-on-the-accuracy-of-positron-emission-tomography-computed-tomography-and-positron-emission-tomography-magnetic-resonance-imaging-in-the-management-of-ovarian-cancer-is-functional-information-really-needed
#19
REVIEW
Subapriya Suppiah, Wing Liong Chang, Hasyma Abu Hassan, Chalermrat Kaewput, Andi Anggeriana Andi Asri, Fathinul Fikri Ahmad Saad, Abdul Jalil Nordin, Sobhan Vinjamuri
Ovarian cancer (OC) often presents at an advanced stage with frequent relapses despite optimal treatment; thus, accurate staging and restaging are required for improving treatment outcomes and prognostication. Conventionally, staging of OC is performed using contrast-enhanced computed tomography (CT). Nevertheless, recent advances in the field of hybrid imaging have made positron emission tomography/CT (PET/CT) and PET/magnetic resonance imaging (PET/MRI) as emerging potential noninvasive imaging tools for improved management of OC...
July 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28646744/systematic-biobanking-novel-imaging-techniques-and-advanced-molecular-analysis-for-precise-tumor-diagnosis-and-therapy-the-polish-mobit-project
#20
Jacek Niklinski, Adam Kretowski, Marcin Moniuszko, Joanna Reszec, Anna Michalska-Falkowska, Magdalena Niemira, Michal Ciborowski, Radoslaw Charkiewicz, Dorota Jurgilewicz, Miroslaw Kozlowski, Rodryg Ramlau, Cezary Piwkowski, Miroslaw Kwasniewski, Monika Kaczmarek, Andrzej Ciereszko, Tomasz Wasniewski, Robert Mroz, Wojciech Naumnik, Ewa Sierko, Magdalena Paczkowska, Joanna Kisluk, Anetta Sulewska, Adam Cybulski, Zenon Mariak, Boguslaw Kedra, Jacek Szamatowicz, Paweł Kurzawa, Lukasz Minarowski, Angelika Edyta Charkiewicz, Barbara Mroczko, Jolanta Malyszko, Christian Manegold, Lothar Pilz, Heike Allgayer, Mohammed L Abba, Hartmut Juhl, Frauke Koch
Personalized and precision medicine is gaining recognition due to the limitations by standard diagnosis and treatment; many areas of medicine, from cancer to psychiatry, are moving towards tailored and individualized treatment for patients based on their clinical characteristics and genetic signatures as well as novel imaging techniques. Advances in whole genome sequencing have led to identification of genes involved in a variety of diseases. Moreover, biomarkers indicating severity of disease or susceptibility to treatment are increasingly being characterized...
June 21, 2017: Advances in Medical Sciences
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