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https://www.readbyqxmd.com/read/29343908/pet-ct-and-pet-mr-in-urological-cancers-other-than-prostate-cancer-an-update-on-state-of-the-art
#1
REVIEW
Abdul Razik, Chandan Jyoti Das, Sanjay Sharma
Hybrid positron emission tomography with computed tomography (PET/CT) and magnetic resonance imaging (PET/MRI) have enabled the combination of morphologic and functional imaging with the promise of providing better information in guiding therapy. Further advance has been made in the past decade with the development of newer radiotracers and optimization of the technical aspects. We performed a search in PubMed, Scopus, and Google Scholar for peer-reviewed literature concerning the advances and newer developments in the imaging of nonprostate urologic cancers between 2005 and 2017...
January 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29333914/hybrid-pet-mri-imaging-in-healthy-unsedated-newborn-infants-with-quantitative-rcbf-measurements-using-15o-water-pet
#2
Julie B Andersen, Ulrich Lindberg, Oline V Olesen, Didier Benoit, Claes N Ladefoged, Henrik Bw Larsson, Liselotte Højgaard, Gorm Greisen, Ian Law
In this study, a new hybrid PET/MRI method for quantitative regional cerebral blood flow (rCBF) measurements in healthy newborn infants was assessed and the low values of rCBF in white matter previously obtained by arterial spin labeling (ASL) were tested. Four healthy full-term newborn subjects were scanned in a PET/MRI scanner during natural sleep after median intravenous injection of 14 MBq 15O-water. Regional CBF was quantified using a one-tissue-compartment model employing an image-derived input function (IDIF) from the left ventricle...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29322269/prognostic-value-of-simultaneous-18f-fdg-pet-mri-using-a-combination-of-metabolo-volumetric-parameters-and-apparent-diffusion-coefficient-in-treated-head-and-neck-cancer
#3
Yong-Il Kim, Gi Jeong Cheon, Seo Young Kang, Jin Chul Paeng, Keon Wook Kang, Dong Soo Lee, June-Key Chung
BACKGROUND: The aim of this study was to determine the usefulness of combined positron emission tomography (PET)/magnetic resonance imaging (MRI) parameters provided by simultaneous 18F-fluorodeoxyglucose (FDG) PET/MRI for the prediction of treatment failure in surgically resected head and neck cancer. We hypothesized that PET parameters corrected by tumor cellularity (combined PET/MRI parameters) could predict the prognosis. On regional PET, maximum standardized uptake value (SUVmax) was measured as metabolic parameters...
January 10, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29303246/simultaneous-pet-mri-confirms-that-cerebral-blood-flow-does-not-confound-pet-neuroreceptor-activation-studies
#4
Lauri Nummenmaa, Lauri Tuominen, Jussi Hirvonen
Positron emission tomography (PET) and endogenous competition paradigms are widely used for studying neuroreceptor activation in humans in vivo. Changes in cerebral blood triggered by the experimentation, such as amphetamine administration, could influence both tracer delivery and washout, thus biasing the results. A recent study tested this assumption in baboons by measuring radiotracer binding with PET while measuring simultaneously cerebral blood flow with arterial spin labeled functional magnetic resonance imaging...
January 5, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29286486/whole-body-pet-mri-of-pediatric-patients-the-details-that-matter
#5
Anuj Pareek, Anne M Muehe, Ashok J Theruvath, Praveen K Gulaka, Sheri L Spunt, Heike E Daldrup-Link
Integrated PET/MRI is a hybrid imaging technique enabling clinicians to acquire diagnostic images for tumor assessment and treatment monitoring with both high soft tissue contrast and added metabolic information. Integrated PET/MRI has shown to be valuable in the clinical setting and has many promising future applications. The protocol presented here will provide step-by-step instructions for the acquisition of whole-body 2-deoxy-2-(18F)fluoro-D-glucose (18F-FDG) PET/MRI data in children with cancer. It also provides instructions on how to combine a whole-body staging scan with a local tumor scan for evaluation of the primary tumor...
December 19, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29282517/11c-met-pet-mri-for-detection-of-recurrent-glioma
#6
C Deuschl, J Kirchner, T D Poeppel, B Schaarschmidt, S Kebir, N El Hindy, J Hense, H H Quick, M Glas, K Herrmann, L Umutlu, C Moenninghoff, A Radbruch, M Forsting, M Schlamann
INTRODUCTION: Radiological assessment of brain tumors is widely based on the Radiology Assessment of Neuro-Oncology (RANO) criteria that consider non-specific T1 and T2 weighted images. Limitation of the RANO criteria is that they do not include metabolic imaging techniques that have been reported to be helpful to differentiate treatment related changes from true tumor progression. In the current study, we assessed if the combined use of MRI and PET with hybrid 11C-MET PET/MRI can improve diagnostic accuracy and diagnostic confidence of the readers to differentiate treatment related changes from true progression in recurrent glioma...
December 28, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29279944/is-the-whole-larger-than-the-sum-of-the-parts-integrated-pet-mri-as-a-tool-for-response-prediction
#7
EDITORIAL
Felix M Mottaghy
No abstract text is available yet for this article.
December 26, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29275475/imaging-the-tumor-microenvironment
#8
Marie-Caline Z Abadjian, W Barry Edwards, Carolyn J Anderson
The tumor microenvironment consists of tumor, stromal, and immune cells, as well as extracellular milieu. Changes in numbers of these cell types and their environments have an impact on cancer growth and metastasis. Non-invasive imaging of aspects of the tumor microenvironment can provide important information on the aggressiveness of the cancer, whether or not it is metastatic, and can also help to determine early response to treatment. This chapter provides an overview on non-invasive in vivo imaging in humans and mouse models of various cell types and physiological parameters that are unique to the tumor microenvironment...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29274757/oncologic-18-f-fdg-pet-ct-what-all-physicians-need-to-know
#9
REVIEW
Jaime L Montilla-Soler, Rikesh J Makanji, Bruce J Barron
Fluorine-18 Fluorodeoxyglucose (18F-FDG) Positron Emission Tomography (PET) hybrid exams (PET/CT, PET/MRI) have become the most common PET imaging tool in the evaluation of the oncologic patient. Therefore, it is of paramount importance that physicians who take care of oncology patients in any capacity, need to be familiar with the basics of when these exams are indicated, how to best prepare the patients, understand the benefits and limitations of the procedure. Additionally, it is important to understand which medical conditions and medications need to be controlled in order to maintain the diagnostic accuracy of these tests...
December 21, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29258847/ssssacute-in-vivo-effect-of-valproic-acid-on-the-gabaergic-system-in-rat-brain-a-11c-ro15-4513-micropet-study
#10
Freja Bertelsen, Anne M Landau, Karina H Vase, Jan Jacobsen, Jørgen Scheel-Krüger, Arne Møller
γ-Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the nervous system acting mainly through GABAA receptors. In the presence of high levels of GABA, an allosteric shift in the GABAA receptors can change the affinity of benzodiazepine (BZD) ligands. Valproic acid (VPA) is an anticonvulsant that enhances the level of endogenous GABA in the brain. The BZD ligand, Ro15-4513 has a high affinity for GABAA receptors containing the α5 subunit and can be used to investigate the GABA shift in the brains of living rats after VPA exposure...
December 16, 2017: Brain Research
https://www.readbyqxmd.com/read/29230607/the-effect-of-high-count-rates-on-cardiac-perfusion-quantification-in-a-simultaneous-pet-mr-system-using-a-cardiac-perfusion-phantom
#11
Jim O' Doherty, Zacharias Chalampalakis, Paul Schleyer, Muhummad Sohaib Nazir, Amedeo Chiribiri, Paul K Marsden
BACKGROUND: PET-MRI is under investigation as a new strategy for quantitative myocardial perfusion imaging. Consideration is required as to the maximum scanner count rate in order to limit dead-time losses resulting from administered activity in the scanner field of view during the first pass of the radiotracer. RESULTS: We performed a decaying-source experiment to investigate the high count-rate performance of a PET-MR system (Siemens mMR) over the expected range of activities during a clinical study...
December 11, 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/29217875/deep-auto-context-convolutional-neural-networks-for-standard-dose-pet-image-estimation-from-low-dose-pet-mri
#12
Lei Xiang, Yu Qiao, Dong Nie, Le An, Qian Wang, Dinggang Shen
Positron emission tomography (PET) is an essential technique in many clinical applications such as tumor detection and brain disorder diagnosis. In order to obtain high-quality PET images, a standard-dose radioactive tracer is needed, which inevitably causes the risk of radiation exposure damage. For reducing the patient's exposure to radiation and maintaining the high quality of PET images, in this paper, we propose a deep learning architecture to estimate the high-quality standard-dose PET (SPET) image from the combination of the low-quality low-dose PET (LPET) image and the accompanying T1-weighted acquisition from magnetic resonance imaging (MRI)...
December 6, 2017: Neurocomputing
https://www.readbyqxmd.com/read/29206885/does-elevated-glucose-metabolism-correlate-with-higher-cell-density-in-neurofibromatosis-type-1-associated-peripheral-nerve-sheath-tumors
#13
Dominik Berzaczy, Marius E Mayerhoefer, Amedeo A Azizi, Alexander R Haug, Daniela Senn, Dietrich Beitzke, Michael Weber, Tatjana Traub-Weidinger
PURPOSE: To investigate whether elevated glucose metabolism in neurofibroma, determined by [F18]-FDG-PET, is correlated with cell density in MRI, as expressed through the apparent diffusion coefficient. MATERIALS AND METHODS: Patients diagnosed with neurofibromatosis type 1 and peripheral nerve sheath tumors (PNST) were enrolled in this prospective, IRB-approved study. After a single [F18]-FDG injection, patients consecutively underwent [F18]-FDG-PET/CT and [F18]-FDG-PET/MRI on the same day...
2017: PloS One
https://www.readbyqxmd.com/read/29200675/neurolymphomatosis-a-surreal-presentation-of-lymphoma
#14
Shikha Khandelwal, Suvinay Saxena, Disha J Hansalia
Background: Neurolymphomatosis is a neurologic complication poorly recognized by neurologists and oncologists and presents usually several months after successful treatment of systemic lymphoma. Other disorders that must be differentiated from these entities include peripheral-nerve or nerve root compression and paraneoplastic neuropathy. Aim: To describe the unusual occurrence of neurolymphomatosis in a patient of B-cell lymphoma. Method: Diagnosis was made by demonstration of enhancement of nerve roots on Magnetic Resonance Imaging of the brachial, lumbosacral plexus, peripheral nerves or by increased hyper-metabolic activity along the course of affected nerves on fluorodeoxyglucose positron emission tomography (FDG-PET)...
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29192363/quantitative-and-visual-assessments-toward-potential-sub-msv-or-ultrafast-fdg-pet-using-high-sensitivity-tof-pet-in-pet-mri
#15
Spencer C Behr, Emma Bahroos, Randall A Hawkins, Lorenzo Nardo, Vahid Ravanfar, Emily V Capbarat, Youngho Seo
PURPOSE: Newer high-performance time-of-flight (TOF) positron emission tomography (PET) systems have the capability to preserve diagnostic image quality with low count density, while maintaining a high raw photon detection sensitivity that would allow for a reduction in injected dose or rapid data acquisition. To assess this, we performed quantitative and visual assessments of the PET images acquired using a highly sensitive (23.3 cps/kBq) large field of view (25-cm axial) silicon photomultiplier (SiPM)-based TOF PET (400-ps timing resolution) integrated with 3 T-MRI in comparison to PET images acquired on non-TOF PET/x-ray computed tomography (CT) systems...
November 30, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29186937/how-to-use-pet-ct-in-the-evaluation-of-response-to-radiotherapy
#16
Pierre Decazes, Sébastien Thureau, Bernard Dubray, Pierre Vera
INTRODUCTION: Radiotherapy is a major treatment modality for many cancers. Tumor response after radiotherapy determines the subsequent steps of the patient's management (surveillance, adjuvant or salvage treatment and palliative care). Tumor response assessed during radiotherapy offers a promising opportunity to adapt the treatment plan to reduced / increased target volume, to specifically target sub-volumes with relevant biological characteristics (metabolism, hypoxia, proliferation ...
November 28, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29186008/pet-attenuation-correction-for-flexible-mri-surface-coils-in-hybrid-pet-mri-using-a-3d-depth-camera
#17
Lynn Johann Frohwein, Mirco Hess, Dominik Schlicher, Konstantin Bolwin, Florian Büther, Xiaoyi Jiang, Klaus P Schäfers
PET attenuation correction for flexible MRI radio frequency surface coils in hybrid PET/MRI is still a challenging task, as position and shape of these coils conform to large inter-patient variabilities. The purpose of this feasibility study is to develop a novel method for the incorporation of attenuation information about flexible surface coils in PET reconstruction using the Microsoft Kinect V2 depth camera. The depth information is used to determine a dense point cloud of the coil's surface representing the shape of the coil...
November 29, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29169313/effect-of-time-of-flight-and-regularized-reconstructions-on-quantitative-measurements-and-qualitative-assessments-in-newly-diagnosed-prostate-cancer-with-18-f-fluorocholine-dual-time-point-pet-mri
#18
Spencer C Behr, Brett J Mollard, Jaewon Yang, Robert R Flavell, Randall A Hawkins, Youngho Seo
Recent technical advances in positron emission tomography/magnetic resonance imaging (PET/MRI) technology allow much improved time-of-flight (TOF) and regularized iterative PET reconstruction regularized iterative reconstruction (RIR) algorithms. We evaluated the effect of TOF and RIR on standardized uptake values (maximum and peak SUV [SUVmax and SUVpeak]) and their metabolic tumor volume dependencies and visual image quality for (18)F-fluorocholine PET/MRI in patients with newly diagnosed prostate cancer...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/29168158/assessment-of-attenuation-correction-for-myocardial-pet-imaging-using-combined-pet-mri
#19
Martin Lyngby Lassen, Sazan Rasul, Dietrich Beitzke, Marie-Elisabeth Stelzmüller, Jacobo Cal-Gonzalez, Marcus Hacker, Thomas Beyer
OBJECTIVE: To evaluate the frequency of artifacts in MR-based attenuation correction (AC) maps and their impact on the quantitative accuracy of PET-based flow and metabolism measurements in a cohort of consecutive heart failure patients undergoing combined PET/MR imaging. METHODS: Myocardial viability studies were performed in 20 patients following a dual-tracer protocol involving the assessment of myocardial perfusion ((13)N-NH3: 813 ± 86 MBq) and metabolism ((18)F-FDG: 335 ± 38 MBq)...
November 22, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29166756/use-of-imaging-techniques-in-large-vessel-vasculitis-and-related-conditions
#20
Annibale Versari, Nicolò Pipitone, Massimiliano Casali, Francois Jamar, Giulia Pazzola
Giant Cell Arteritis (GCA) and Takayasu's arteritis (TA) are large vessel vasculitis (LVV) primarily affecting the aorta and its major branches, mainly differentiated by the onset age (>50 years GCA and <40 years TA). In addition, temporal artery involvement and polymyalgia rheumatic are typical features of GCA, but not TA. Imaging techniques are required to secure the diagnosis of large-vessel vasculitides, and to monitor the disease course. Both morphological and metabolic imaging are involved. Morphological imaging is represented mainly by Computerized Tomography (CT), CT angiography, Magnetic Resonance (MR), MR angiography, Color-Doppler Sonography (CDS) and high-resolution CDS...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
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