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https://www.readbyqxmd.com/read/28932900/-68ga-pentixafor-pet-mri-for-the-detection-of-chemokine-receptor-4-expression-in-atherosclerotic-plaques
#1
Xiang Li, Daniel Heber, Tatjana Leike, Dietrich Beitzke, Xia Lu, Xiaoli Zhang, Yongxiang Wei, Markus Mitterhauser, Wolfgang Wadsak, Saskia Kropf, Hans J Wester, Christian Loewe, Marcus Hacker, Alexander R Haug
PURPOSE: The expression of chemokine receptor type 4 (CXCR4) was found co-localized with macrophages on the atherosclerotic vessel wall and participated in the initial emigration of leukocytes. Gallium-68 [(68)Ga]Pentixafor has recently been introduced for the imaging of atherosclerosis by targeting CXCR4. We sought to evaluate human atherosclerotic lesions using [(68)Ga]Pentixafor PET/MRI. METHODS: Thirty-eight oncology patients underwent [(68)Ga]Pentixafor PET/MR imaging at baseline...
September 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28929350/optimal-mri-sequences-for-68-ga-psma-11-pet-mri-in-evaluation-of-biochemically-recurrent-prostate-cancer
#2
Spencer T Lake, Kirsten L Greene, Antonio C Westphalen, Spencer C Behr, Ronald Zagoria, Eric J Small, Peter R Carroll, Thomas A Hope
BACKGROUND: PET/MRI can be used for the detection of disease in biochemical recurrence (BCR) patients imaged with (68)Ga-PSMA-11 PET. This study was designed to determine the optimal MRI sequences to localize positive findings on (68)Ga-PSMA-11 PET of patients with BCR after definitive therapy. Fifty-five consecutive prostate cancer patients with BCR imaged with (68)Ga-PSMA-11 3.0T PET/MRI were retrospectively analyzed. Mean PSA was 7.9 ± 12.9 ng/ml, and mean PSA doubling time was 7...
September 19, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28913789/cardiac-sarcoidosis-after-glucocorticoid-therapy-evaluated-by-18-f-fluorodeoxyglucose-pet-mri
#3
Takatoyo Kiko, Atsuro Masuda, Ayaka Nemoto, Hideyuki Tominaga, Noboru Oriuchi, Akiomi Yoshihisa, Yasuchika Takeishi
No abstract text is available yet for this article.
September 14, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28910997/paediatric-nuclear-medicine-imaging
#4
Lorenzo Biassoni, Marina Easty
Background: Nuclear medicine imaging explores tissue viability and function by using radiotracers that are taken up at cellular level with different mechanism. This imaging technique can also be used to assess blood flow and transit through tubular organs. Nuclear medicine imaging has been used in paediatrics for decades and this field is continuously evolving. Sources of data: The data presented comes from clinical experience and some milestone papers on the subject...
September 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28905091/added-value-of-dedicated-axillary-hybrid-18f-fdg-pet-mri-for-improved-axillary-nodal-staging-in-clinically-node-positive-breast-cancer-patients-a-feasibility-study
#5
Thiemo J A van Nijnatten, B Goorts, S Vöö, M de Boer, L F S Kooreman, E M Heuts, J E Wildberger, F M Mottaghy, M B I Lobbes, M L Smidt
PURPOSE: To investigate the feasibility and potential added value of dedicated axillary 18F-FDG hybrid PET/MRI, compared to standard imaging modalities (i.e. ultrasound [US], MRI and PET/CT), for axillary nodal staging in clinically node-positive breast cancer. METHODS: Twelve patients with clinically node-positive breast cancer underwent axillary US and dedicated axillary hybrid 18F-FDG PET/MRI. Nine of the 12 patients also underwent whole-body PET/CT. Maximum standardized uptake values (SUVmax) were measured for the primary breast tumor and the most FDG-avid axillary lymph node...
September 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28885539/a-comparison-of-18f-fdg-pet-mr-with-pet-ct-in-pulmonary-tuberculosis
#6
Benjamin A Thomas, James S Molton, Francesca Leek, Yan Pang, John J Totman, Nicholas I Paton, David W Townsend
PURPOSE: PET/computed tomography (CT) has been shown to detect lesions in patients with pulmonary tuberculosis (PTB) and may be useful for assessing PTB disease in clinical research studies. However, radiation dose is of concern for clinical research in individuals with an underlying curable disease. This study aimed to determine whether PET/MR is equivalent to PET/CT in PTB. MATERIALS AND METHODS: Ten patients with microbiologically confirmed PTB were recruited...
September 6, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28862997/a-novel-optically-transparent-rf-shielding-for-fully-integrated-pet-mri-systems
#7
C Parl, A Kolb, A M Schmid, H F Wehrl, J A Disselhorst, P D Soubiran, D Stricker-Shaver, B J Pichler
Preclinical imaging benefits from simultaneous acquisition of high-resolution anatomical and molecular data. Additionally, PET/MRI systems can provide functional PET and functional MRI data. To optimize PET sensitivity, we propose a system design that fully integrates the MRI coil into the PET system. This allows positioning the scintillators near the object but requires an optimized design of the MRI coil and PET detector. It further requires a new approach in realizing the radiofrequency (RF) shielding. Thus, we propose the use of an optically transparent RF shielding material between the PET scintillator and the light sensor, suppressing the interference between both systems...
September 1, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28844925/case-study-multimodal-18-f-fluciclovine-pet-mri-and-ultrasound-guided-neurosurgery-of-an-anaplastic-oligodendroglioma
#8
Anna Karlberg, Erik Magnus Berntsen, Håkon Johansen, Mariane Myrthue, Anne Jarstein Skjulsvik, Ingerid Reinertsen, Morteza Esmaeili, Hong Yan Dai, Yiming Xiao, Hassan Rivaz, Per Borghammer, Ole Solheim, Live Eikenes
BACKGROUND: Structural MRI and histopathological tissue sampling are routinely performed as part of the diagnostic work-up of glioma patients. Due to the heterogeneous nature of gliomas, there is however a risk of undergrading caused by histopathological sampling errors. MRI has limitations in identifying tumor grade and type, detecting diffuse invasive growth, and separating recurrences from treatment induced changes. PET can provide quantitative information of cellular activity and metabolism, and may therefore complement MRI...
August 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28840302/comparison-of-18-f-fdg-pet-mri-and-mri-for-pre-therapeutic-tumor-staging-of-patients-with-primary-cancer-of-the-uterine-cervix
#9
Theresia Sarabhai, Benedikt M Schaarschmidt, Axel Wetter, Julian Kirchner, Bahriye Aktas, Michael Forsting, Verena Ruhlmann, Ken Herrmann, Lale Umutlu, Johannes Grueneisen
PURPOSE: The aim of the present study was to assess and compare the diagnostic performance of integrated PET/MRI and MRI alone for local tumor evaluation and whole-body tumor staging of primary cervical cancers. In addition, the corresponding impact on further patient management of the two imaging modalities was assessed. METHODS: A total of 53 consecutive patients with histopathological verification of a primary cervical cancer were prospectively enrolled for a whole-body 18F-FDG PET/MRI examination...
August 24, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28831583/18f-fdg-pet-detects-complete-response-to-pd1-therapy-in-melanoma-patients-two-weeks-after-therapy-start
#10
Ferdinand Seith, Andrea Forschner, Holger Schmidt, Christina Pfannenberg, Brigitte Gückel, Konstantin Nikolaou, Christian la Fougère, Claus Garbe, Nina Schwenzer
PURPOSE: The aim of the study was to evaluate if 18F-FDG-PET has the potential to detect complete responders to PD1-therapy in patients with unresectable metastasized melanoma two weeks after therapy initiation. METHODS: Between September 2014 and May 2016, ten patients (four females; 65 ± 12 y) received a whole-body 18F-FDG-PET/MRI examination at three time points: Before therapy start (t0, base-line), two weeks (t1, study examination) and three months after treatment initiation (t2, reference standard)...
August 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28817656/investigation-of-the-halo-artifact-in-68ga-psma-11-pet-mri
#11
Thorsten Heußer, Philipp Mann, Christopher M Rank, Martin Schäfer, Antonia Dimitrakopoulou-Strauss, Heinz-Peter Schlemmer, Boris A Hadaschik, Klaus Kopka, Peter Bachert, Marc Kachelrieß, Martin T Freitag
OBJECTIVES: Combined positron emission tomography (PET) and magnetic resonance imaging (MRI) targeting the prostate-specific membrane antigen (PSMA) with a 68Ga-labelled PSMA-analog (68Ga-PSMA-11) is discussed as a promising diagnostic method for patients with suspicion or history of prostate cancer. One potential drawback of this method are severe photopenic (halo-) artifacts surrounding the bladder and the kidneys in the scatter-corrected PET images, which have been reported to occur frequently in clinical practice...
2017: PloS One
https://www.readbyqxmd.com/read/28816571/effects-of-flow-changes-on-radiotracer-binding-simultaneous-measurement-of-neuroreceptor-binding-and-cerebral-blood-flow-modulation
#12
Christin Y Sander, Joseph B Mandeville, Hsiao-Ying Wey, Ciprian Catana, Jacob M Hooker, Bruce R Rosen
The potential effects of changes in blood flow on the delivery and washout of radiotracers has been an ongoing question in PET bolus injection studies. This study provides practical insight into this topic by experimentally measuring cerebral blood flow (CBF) and neuroreceptor binding using simultaneous PET/MRI. Hypercapnic challenges (7% CO2) were administered to non-human primates in order to induce controlled increases in CBF, measured with pseudo-continuous arterial spin labeling. Simultaneously, dopamine D2/D3 receptor binding of [(11)C]raclopride or [(18)F]fallypride was monitored with dynamic PET...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28814136/hybrid-core-shell-nanoparticles-entrapping-gd-dtpa-and-18-f-fdg-for-simultaneous-pet-mri-acquisitions
#13
Donatella Vecchione, Marco Aiello, Carlo Cavaliere, Emanuele Nicolai, Paolo Antonio Netti, Enza Torino
AIM: Although there has been an improvement in the hardware and software of the PET/MRI system, the development of the nanoprobes exploiting the simultaneous acquisition of the bimodal data is still under investigation. Moreover, few studies on biocompatible and clinically relevant probes are available. This work presents a core-shell polymeric nanocarrier with improved relaxometric properties for simultaneous PET/MRI acquisitions. MATERIALS & METHODS: Core-shell nanoparticles entrapping the Gd-DTPA and (18)F-FDG are obtained by a complex coacervation...
August 17, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28812148/local-recurrence-of-squamous-cell-carcinoma-of-the-head-and-neck-after-radio-chemo-therapy-diagnostic-performance-of-fdg-pet-mri-with-diffusion-weighted-sequences
#14
Minerva Becker, Arthur D Varoquaux, Christophe Combescure, Olivier Rager, Marc Pusztaszeri, Karim Burkhardt, Bénédicte M A Delattre, Pavel Dulguerov, Nicolas Dulguerov, Eirini Katirtzidou, Francesca Caparrotti, Osman Ratib, Habib Zaidi, Christoph D Becker
PURPOSE: To determine the diagnostic performance of FDG-PET/MRI with diffusion-weighted imaging (FDG-PET/DWIMRI) for detection and local staging of head and neck squamous cell carcinoma (HNSCC) after radio(chemo)therapy. MATERIALS AND METHODS: This was a prospective study that included 74 consecutive patients with previous radio(chemo)therapy for HNSCC and in whom tumour recurrence or radiation-induced complications were suspected clinically. The patients underwent hybrid PET/MRI examinations with morphological MRI, DWI and FDG-PET...
August 15, 2017: European Radiology
https://www.readbyqxmd.com/read/28806243/ictal-18f-fdg-pet-mri-in-a-patient-with-cortical-heterotopia-and-focal-epilepsy
#15
Ferdinando F Calabria, Giuseppe Lucio Cascini, Antonio Gambardella, Angelo Labate, Andrea Cherubini, Domenico Gullà, Benedetta Tafuri, Umberto Sabatini, Virginia Vescio, Aldo Quattrone
A 19-year-old man with epilepsy underwent ictal F-FDG PET/MRI, showing a 5 mm heterotopic nodule in the periventricular white matter, adjacent to the frontal horn of the left lateral ventricle (SUVmax, 5.5; glucidic cerebral metabolic rate, 0.317 μmol/mL). A repeated F-FDG PET/MRI, during seizure freedom, showed, at visual analysis, subtle decrease of the nodule metabolism. SUVmax and glucidic cerebral metabolic rate were clearly reduced to 3.7 and 0.226, respectively. Ictal F-FDG PET/MRI could be useful in epilepsy because of the added value of SUVmax and cerebral metabolic rate of glucose analysis to understand the relationship between heterotopy and epilepsy...
October 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28804704/hypoxia-in-cervical-cancer-from-biology-to-imaging
#16
REVIEW
Heidi Lyng, Eirik Malinen
PURPOSE: Hypoxia imaging may improve identification of cervical cancer patients at risk of treatment failure and be utilized in treatment planning and monitoring, but its clinical potential is far from fully realized. Here, we briefly describe the biology of hypoxia in cervix tumors of relevance for imaging, and evaluate positron emission tomography (PET) and magnetic resonance imaging (MRI) techniques that have shown promise for assessing hypoxia in a clinical setting. We further discuss emerging imaging approaches, and how imaging can play a role in future treatment strategies to target hypoxia...
2017: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28802328/hybrid-pet-mri-co-segmentation-based-on-joint-fuzzy-connectedness-and-graph-cut
#17
Arafet Sbei, Khaoula ElBedoui, Walid Barhoumi, Philippe Maksud, Chokri Maktouf
BACKGROUND AND OBJECTIVE: Tumor segmentation from hybrid PET/MRI scans may be highly beneficial in radiotherapy treatment planning. Indeed, it gives for both modalities the suitable information that could make the delineation of tumors more accurate than using each one apart. We aim in this work to propose a co-segmentation method that deals with several challenges, notably the lack of one-to-one correspondence between tumors of the two modalities and the boundaries' smoothing. METHODS: The proposed method is designed to surpass these limits, we propose a segmentation method based on the GCsum(max) technique...
October 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28798033/a-prospective-study-comparing-99m-tc-hdp-planar-bone-scintigraphy-and-whole-body-spect-ct-with-18-f-fluoride-pet-ct-and-18-f-fluoride-pet-mri-for-diagnosing-bone-metastases
#18
Johan Löfgren, Jann Mortensen, Sine Hvid Rasmussen, Claus Madsen, Annika Loft, Adam Espe Hansen, Peter Oturai, Karl Erik Jensen, Mette Louise Mørk, Michala Reichkendler, Liselotte Højgaard, Barbara M Fischer
We prospectively evaluate and compare the diagnostic performance of (99m)Tc-HDP planar bone scintigraphy (pBS), (99m)Tc-HDP SPECT/CT, (18)F-NaF PET/CT and (18)F-NaF PET/MRI for the detection of bone metastases. Methods: 117 patients with histologically proven malignancy referred for clinical pBS were prospectively enrolled. pBS and whole-body SPECT/CT were performed followed by (18)F-NaF PET/CT within 9 days. (18)F-NaF PET/MRI was also performed in 46 patients. A "truth panel" including clinical follow-up served as standard of reference...
August 10, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28777652/semiquantitative-assessment-of-18-f-fdg-uptake-in-the-normal-skeleton-comparison-between-pet-ct-and-time-of-flight-simultaneous-pet-mri
#19
Ryogo Minamimoto, Guofan Xu, Mehran Jamali, Dawn Holley, Amir Barkhodari, Greg Zaharchuk, Andrei Iagaru
OBJECTIVE: Differences in the attenuation correction methods used in PET/CT scanners versus the newly introduced whole-body simultaneous PET/MRI reportedly result in differences in standardized uptake values (SUVs) in the normal skeleton. The aim of the study was to compare the semiquantitative FDG uptake in the normal skeleton using time-of-flight (TOF) PET/MRI versus PET/CT with and without TOF. SUBJECTS AND METHODS: Participants received a single FDG injection and underwent non-TOF and TOF PET/CT (n = 23) or non-TOF PET/CT and TOF PET/MRI (n = 50)...
August 4, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28765286/long-delay-arterial-spin-labeling-provides-more-accurate-cerebral-blood-flow-measurements-in-moyamoya-patients-a-simultaneous-positron-emission-tomography-mri-study
#20
Audrey P Fan, Jia Guo, Mohammad M Khalighi, Praveen K Gulaka, Bin Shen, Jun Hyung Park, Harsh Gandhi, Dawn Holley, Omar Rutledge, Prachi Singh, Tom Haywood, Gary K Steinberg, Frederick T Chin, Greg Zaharchuk
BACKGROUND AND PURPOSE: Arterial spin labeling (ASL) MRI is a promising, noninvasive technique to image cerebral blood flow (CBF) but is difficult to use in cerebrovascular patients with abnormal, long arterial transit times through collateral pathways. To be clinically adopted, ASL must first be optimized and validated against a reference standard in these challenging patient cases. METHODS: We compared standard-delay ASL (post-label delay=2.025 seconds), multidelay ASL (post-label delay=0...
August 1, 2017: Stroke; a Journal of Cerebral Circulation
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