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https://www.readbyqxmd.com/read/27920894/recent-advances-in-the-preparation-and-application-of-multifunctional-iron-oxide-and-liposome-based-nanosystems-for-multimodal-diagnosis-and-therapy
#1
REVIEW
Marzia Marciello, Juan Pellico, Irene Fernandez-Barahona, Fernando Herranz, Jesus Ruiz-Cabello, Marco Filice
Nowadays, thanks to the successful discoveries in the biomedical field achieved in the last two decades, a deeper understanding about the complexity of mechanistic aspects of different pathological processes has been obtained. As a consequence, even the standard therapeutic protocols have undergone a vast redesign. In fact, the awareness about the necessity to progress towards a combined multitherapy in order to potentially increase the final healing chances has become a reality. One of the crucial elements of this novel approach is that large amounts of detailed information are highly needed and in vivo imaging techniques represent one of the most powerful tools to visualize and monitor the pathological state of the patient...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27913827/intra-lesional-spatial-correlation-of-static-and-dynamic-fet-pet-parameters-with-mri-based-cerebral-blood-volume-in-patients-with-untreated-glioma
#2
Jens Göttler, Mathias Lukas, Anne Kluge, Stephan Kaczmarz, Jens Gempt, Florian Ringel, Mona Mustafa, Bernhard Meyer, Claus Zimmer, Markus Schwaiger, Stefan Förster, Christine Preibisch, Thomas Pyka
PURPOSE: (18)F-fluorethyltyrosine-(FET)-PET and MRI-based relative cerebral blood volume (rCBV) have both been used to characterize gliomas. Recently, inter-individual correlations between peak static FET-uptake and rCBV have been reported. Herein, we assess the local intra-lesional relation between FET-PET parameters and rCBV. METHODS: Thirty untreated glioma patients (27 high-grade) underwent simultaneous PET/MRI on a 3 T hybrid scanner obtaining structural and dynamic susceptibility contrast sequences...
December 2, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27911313/challenges-in-screening-and-recruitment-for-a-neuroimaging-study-in-cognitively-impaired-geriatric-inpatients
#3
Ivayla Apostolova, Catharina Lange, Anna Roberts, Hans Joachim Igel, Anja Mäurer, Stephanie Liese, Melanie Estrella, Vikas Prasad, Elisabeth Stechl, Gernot Lämmler, Elisabeth Steinhagen-Thiessen, Ralph Buchert
BACKGROUND: Neuroimaging-based biomarkers have the potential to improve etiological diagnosis of cognitive impairment in elderly inpatients. However, there is a relative lack of studies on neuroimaging-based biomarkers in hospitalized geriatric patients, as the vast majority of neuroimaging studies in dementia have focused on memory clinic outpatients. An important aspect of study planning is a priori estimation of the rate of screen failures. OBJECTIVE: To report on the rate and causes of screen failures in a prospective study on the utility of neuroimaging (PET, MRI) for the etiological diagnosis of newly manifested cognitive impairment in acutely hospitalized geriatric patients...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27907162/simultaneous-11c-methionine-positron-emission-tomography-magnetic-resonance-imaging-of-suspected-primary-brain-tumors
#4
Cornelius Deuschl, Sophia Goericke, Johannes Grueneisen, Lino Morris Sawicki, Juliane Goebel, Nicolai El Hindy, Karsten Wrede, Ina Binse, Thorsten Poeppel, Harald Quick, Michael Forsting, Joerg Hense, Lale Umutlu, Marc Schlamann
INTRODUCTION: The objective of this study was to assess the diagnostic value of integrated 11C- methionine PET/MRI for suspected primary brain tumors, in comparison to MRI alone. MATERIAL AND METHODS: Forty-eight consecutive patients with suspected primary brain tumor were prospectively enrolled for an integrated 11C-methionine PET/MRI. Two neuro-radiologists separately evaluated the MRI alone and the integrated PET/MRI data sets regarding most likely diagnosis and diagnostic confidence on a 5-point scale...
2016: PloS One
https://www.readbyqxmd.com/read/27898647/diffusion-weighted-mri-and-18f-fdg-pet-ct-imaging-competition-or-synergy-as-diagnostic-methods-to-manage-sarcoma-of-the-uterus-a-systematic-review-of-the-literature
#5
Julien Dubreuil, Jeremie Tordo, Domenico Rubello, Francesco Giammarile, Andrea Skanjeti
AIM: To evaluate the diagnostic performance of fluorine-18-fluorodeoxyglucose PET/computed tomography (F-FDG-PET/CT) and MRI with diffusion-weighted images (DWI) in uterine sarcomas (US). PATIENTS AND METHODS: A systematic review was performed on Medline, ISI web of knowledge, and Scopus databases for studies reporting the diagnostic performance of F-FDG-PET/CT and DWI-MRI in US published up to 15 February 2016. Exclusion criteria were articles with fewer than five cases of US, without DWI-MRI, and previous series of patients from the same researcher team...
January 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27885810/value-of-18-f-fdg-pet-mri-for-the-outcome-of-ct-guided-facet-block-therapy-in-cervical-facet-syndrome-initial-results
#6
Lino M Sawicki, Benedikt M Schaarschmidt, Philipp Heusch, Christian Buchbender, Sandra Rosenbaum-Krumme, Lale Umutlu, Sven O Eicker, Andreas Bockisch, Gerald Antoch, Frank W Floeth
INTRODUCTION: The aim of this study was to evaluate the ability of (18) F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging ((18) F-FDG PET/MRI) to detect PET-positive cervical facet arthropathy and identify patients who benefit from facet block therapy. METHODS: Ten patients with cervical facet syndrome (mean age: 65 ± 12 years) underwent (18) F-FDG PET/MRI of the neck. Focal (18) F-FDG uptake in PET-positive facet joints served as target for computed tomography (CT)-guided facet blocks...
November 25, 2016: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/27882307/metabolic-imaging-in-prostate-cancer-where-we-are
#7
REVIEW
Claudia Testa, Cristian Pultrone, David Neil Manners, Riccardo Schiavina, Raffaele Lodi
In recent years, the development of diagnostic methods based on metabolic imaging has been aimed at improving diagnosis of prostate cancer (PCa) and perhaps at improving therapy. Molecular imaging methods can detect specific biological processes that are different when detected within cancer cells relative to those taking place in surrounding normal tissues. Many methods are sensitive to tissue metabolism; among them, positron emission tomography (PET) and magnetic resonance spectroscopic imaging (MRSI) are widely used in clinical practice and clinical research...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27871000/comparison-of-atlas-based-techniques-for-whole-body-bone-segmentation
#8
Hossein Arabi, Habib Zaidi
We evaluate the accuracy of whole-body bone extraction from whole-body MR images using a number of atlas-based segmentation methods. The motivation behind this work is to find the most promising approach for the purpose of MRI-guided derivation of PET attenuation maps in whole-body PET/MRI. To this end, a variety of atlas-based segmentation strategies commonly used in medical image segmentation and pseudo-CT generation were implemented and evaluated in terms of whole-body bone segmentation accuracy. Bone segmentation was performed on 23 whole-body CT/MR image pairs via leave-one-out cross validation procedure...
November 12, 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/27825433/advancement-of-mr-and-pet-mr-in-prostate-cancer
#9
REVIEW
Liza Lindenberg, Mark Ahlman, Baris Turkbey, Esther Mena, Peter Choyke
Multiparametric magnetic resonance (mpMRI) imaging has assumed a larger role in the diagnosis and management of prostate cancer. The current method of detecting prostate cancer relies on blind systematic biopsy, guided only by transrectal ultrasound that generally directs the needle biopsy to sextants of the prostate rather than specific lesions. MpMRI is playing an increasing role in the detection of primary cancer as it can visualize cancers and direct biopsies. However, even mpMRI is inherently nonspecific and numerous biopsies performed under MR guidance prove to be negative...
November 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27824966/update-of-the-role-of-pet-ct-and-pet-mri-in-the-management-of-patients-with-cervical-cancer
#10
Benjapa Khiewvan, Drew A Torigian, Sahra Emamzadehfard, Koosha Paydary, Ali Salavati, Sina Houshmand, Sara Pourhassan Shamchi, Thomas J Werner, Aysel Aydin, Shambo Guha Roy, Abass Alavi, Rakesh Kumar
In cervical cancer (CC), fluorine18-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) has been proven to be beneficial for patient management. Positron emission tomography/CT is useful in pretreatment evaluation due to the ability to evaluate disease extent and to assess regional lymph nodes as well as distant sites for metastases. Positron emission tomography/CT has an impact on treatment planning as well as it is incorporated in radiation therapy planning, resulting in more appropriate and effective treatment with less cost and radiation dose to normal tissues...
November 8, 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27817158/a-pet-mri-study-towards-finding-the-optimal-18-f-fluciclovine-pet-protocol-for-detection-and-characterisation-of-primary-prostate-cancer
#11
Mattijs Elschot, Kirsten M Selnæs, Elise Sandsmark, Brage Krüger-Stokke, Øystein Størkersen, May-Britt Tessem, Siver A Moestue, Helena Bertilsson, Tone F Bathen
PURPOSE: [(18)F]Fluciclovine PET imaging shows promise for the assessment of prostate cancer. The purpose of this PET/MRI study is to optimise the PET imaging protocol for detection and characterisation of primary prostate cancer, by quantitative evaluation of the dynamic uptake of [(18)F]Fluciclovine in cancerous and benign tissue. METHODS: Patients diagnosed with high-risk primary prostate cancer underwent an integrated [(18)F]Fluciclovine PET/MRI exam before robot-assisted radical prostatectomy with extended pelvic lymph node dissection...
November 5, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27812923/the-effect-of-defective-pet-detectors-in-clinical-simultaneous-18-f-fdg-time-of-flight-pet-mr-imaging
#12
Edwin E G W Ter Voert, Gaspar Delso, Felipe de Galiza Barbosa, Martin Huellner, Patrick Veit-Haibach
PURPOSE: The purpose of this study was to evaluate the effect of defective positron emission tomography (PET) detectors on clinical PET image quality in simultaneous PET/magnetic resonance imaging (MRI) for both time-of-flight (TOF) and non-TOF reconstructed images. PROCEDURES: A total of six patients with various malignant tumors were included and underwent a 2-deoxy-2-[(18)F]fluoro-D-glucose PET scan in a fully functional simultaneous TOF PET/MRI. TOF and non-TOF PET images were reconstructed before and after simulating defective detector units...
November 3, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27806602/whole-body-bone-segmentation-from-mri-for-pet-mri-attenuation-correction-using-shape-based-averaging
#13
Hossein Arabi, Habib Zaidi
PURPOSE: The authors evaluate the performance of shape-based averaging (SBA) technique for whole-body bone segmentation from MRI in the context of MRI-guided attenuation correction (MRAC) in hybrid PET/MRI. To enhance the performance of the SBA scheme, the authors propose to combine it with statistical atlas fusion techniques. Moreover, a fast and efficient shape comparison-based atlas selection scheme was developed and incorporated into the SBA method. METHODS: Clinical studies consisting of PET/CT and MR images of 21 patients were used to assess the performance of the SBA method...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27805423/the-potential-of-multiparametric-mri-of-the-breast
#14
Katja Pinker, Thomas H Helbich, Elizabeth A Morris
Magnetic resonance imaging (MRI) is an essential tool in breast imaging, with multiple established indications. Dynamic contrast-enhanced MRI (DCE-MRI) is the backbone of any breast MRI protocol and has an excellent sensitivity and good specificity for breast cancer diagnosis. DCE-MRI provides high-resolution morphological information, as well as some functional information about neo-angiogenesis as a tumour-specific feature. To overcome limitations in specificity, several other functional MRI parameters have been investigated and the application of these combined parameters is defined as multiparametric MRI (mpMRI) of the breast...
November 2, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27800198/a-case-report-of-neurosarcoidosis-presenting-as-a-lymphoma-mimic
#15
Gurcharanjeet Kaur, Lauren Cameron, Olga Syritsyna, Patricia Coyle, Agnes Kowalska
Objective. To describe a unique presentation of neurosarcoidosis. Background. Central nervous system involvement is rare in sarcoidosis. Sarcoidosis can be severe and can be mistaken for systemic lymphoma. Case Description. A 55-year-old right-handed white male with past medical history of obstructive sleep apnea, Raynaud's disease, and Hashimoto's thyroiditis was noted to have cognitive decline over a duration of few weeks and 20 lb weight loss. His neurologic exam (including cranial nerves) was normal except for five-minute recall...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27796082/pet-mri-of-metabolic-activity-in-osteoarthritis-a-feasibility-study
#16
Feliks Kogan, Audrey P Fan, Emily J McWalter, Edwin H G Oei, Andrew Quon, Garry E Gold
PURPOSE: To evaluate positron emission tomography / magnetic resonance imaging (PET/MRI) knee imaging to detect and characterize osseous metabolic abnormalities and correlate PET radiotracer uptake with osseous abnormalities and cartilage degeneration observed on MRI. MATERIALS AND METHODS: Both knees of 22 subjects with knee pain or injury were scanned at one timepoint, without gadolinium, on a hybrid 3.0T PET-MRI system following injection of (18) F-fluoride or (18) F-fluorodeoxyglucose (FDG)...
October 31, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27789718/imaging-the-cytokine-receptor-cxcr4-in-atherosclerotic-plaques-with-the-radiotracer-68ga-pentixafor-for-positron-emission-tomography
#17
Fabien Hyafil, Jaroslav Pelisek, Iina Laitinen, Margret Schottelius, Miriam Mohring, Yvonne Döring, Emiel Van der Vorst, Michael Kallmayer, Katja Steiger, Andreas Poschenrieder, Johannes Notni, Johannes Fischer, Christine Baumgartner, Christoph Rischpler, Stephan Nekolla, Christian Weber, Hans-Henning Eckstein, Hans-Jürgen Wester, Markus Schwaiger
: (68)Ga-pentixafor is a radiotracer for positron emission tomography (PET) that binds with nanomolar affinity to CXCR4. The CXCR4 receptor is expressed at the surface of inflammatory cells. The objective of the study was to analyze the ability of radiolabeled pentixafor to detect CXCR4 expression on inflammatory cells present in atherosclerotic plaques of an experimental rabbit model. METHODS: Atherosclerotic plaques were induced by endothelial abrasion of the right carotid artery and abdominal aorta of 7 rabbits fed an atherogenic diet...
October 27, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27782167/renoprotective-effects-of-metformin-are-independent-of-organic-cation-transporters-1-2-and-amp-activated-protein-kinase-in-the-kidney
#18
Michael Christensen, Jonas B Jensen, Steen Jakobsen, Niels Jessen, Jørgen Frøkiær, Bruce E Kemp, Allison L Marciszyn, Hui Li, Núria M Pastor-Soler, Kenneth R Hallows, Rikke Nørregaard
The type-2 diabetes drug metformin has proven to have protective effects in several renal disease models. Here, we investigated the protective effects in a 3-day unilateral ureteral obstruction (3dUUO) mouse model. Compared with controls, ureteral obstructed animals displayed increased tubular damage and inflammation. Metformin treatment attenuated inflammation, increased the anti-oxidative response and decreased tubular damage. Hepatic metformin uptake depends on the expression of organic cation transporters (OCTs)...
October 26, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27779126/mr-compatibility-of-a-high-resolution-small-animal-pet-insert-operating-inside-a-7-t-mri
#19
J D Thiessen, E Shams, G Stortz, G Schellenberg, D Bishop, M S Khan, P Kozlowski, F Retière, V Sossi, C J Thompson, A L Goertzen
A full-ring PET insert consisting of 16 PET detector modules was designed and constructed to fit within the 114 mm diameter gradient bore of a Bruker 7 T MRI. The individual detector modules contain two silicon photomultiplier (SiPM) arrays, dual-layer offset LYSO crystal arrays, and high-definition multimedia interface (HDMI) cables for both signal and power transmission. Several different RF shielding configurations were assessed prior to construction of a fully assembled PET insert using a combination of carbon fibre and copper foil for RF shielding...
November 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27776644/hybrid-imaging-for-detection-of-carcinoma-of-unknown-primary-a-preliminary-comparison-trial-of-whole-body-pet-mri-versus-pet-ct
#20
Verena Ruhlmann, Marcus Ruhlmann, Alexander Bellendorf, Johannes Grueneisen, Lino M Sawicki, Hong Grafe, Michael Forsting, Andreas Bockisch, Lale Umutlu
PURPOSE: The aim of this study is to evaluate and compare the diagnostic potential of integrated whole-body [18F]FDG-PET/MRI to [18F]FDG-PET/CT for detection of a potential primary cancer and metastases in patients suspected for cancer of unknown primary (CUP). METHODS: A total of 20 patients (15 male, 5 female, age 53±13 years) suspect for CUP underwent a dedicated head and neck & whole-body [18F]FDG-PET/CT (Biograph mCT 128, Siemens Healthcare) and a subsequent simultaneous [18F]FDG-PET/MRI examination (Biograph mMR, Siemens Healthcare)...
November 2016: European Journal of Radiology
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