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https://www.readbyqxmd.com/read/29147764/prospective-evaluation-of-18-f-facbc-pet-ct-and-pet-mri-versus-multiparametric-mri-in-intermediate-to-high-risk-prostate-cancer-patients-flucipro-trial
#1
Ivan Jambor, Anna Kuisma, Esa Kähkönen, Jukka Kemppainen, Harri Merisaari, Olli Eskola, Jarmo Teuho, Ileana Montoya Perez, Marko Pesola, Hannu J Aronen, Peter J Boström, Pekka Taimen, Heikki Minn
PURPOSE: The purpose of this study was to evaluate (18)F-FACBC PET/CT, PET/MRI, and multiparametric MRI (mpMRI) in detection of primary prostate cancer (PCa). METHODS: Twenty-six men with histologically confirmed PCa underwent PET/CT immediately after injection of 369 ± 10 MBq (18)F-FACBC (fluciclovine) followed by PET/MRI started 55 ± 7 min from injection. Maximum standardized uptake values (SUVmax) were measured for both hybrid PET acquisitions. A separate mpMRI was acquired within a week of the PET scans...
November 16, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29143875/the-role-of-18f-fdg-pet-ct-and-pet-mri-in-pancreatic-ductal-adenocarcinoma
#2
Randy Yeh, Laurent Dercle, Ishan Garg, Zhen Jane Wang, David M Hough, Ajit H Goenka
Pancreatic ductal adenocarcinoma (PDAC) remains a difficult disease to treat and continues to portend a poor prognosis, as most patients are unresectable at diagnosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) combined with CT (PET/CT) has been a cornerstone in oncological imaging of different cancers; however, the role of PET/CT in PDAC is continually evolving and currently not well established. Studies have shown the potential of PET/CT in guiding the management of patients with PDAC, with possible added benefit over anatomic imaging with CT or MRI in certain scenarios...
November 16, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29127246/non-oncologic-applications-of-pet-ct-and-pet-mr-in-musculoskeletal-orthopedic-and-rheumatologic-imaging-general-considerations-techniques-and-radiopharmaceuticals
#3
Ali Gholamrezanezhad, Kyle Basques, Ali Batouli, Mojtaba Olyaie, George Matcuk, Abass Alavi, Hossein Jadvar
Positron Emission Tomography (PET) is often underutilized in the field of musculoskeletal imaging, with key reasons including the excellent performance of conventional musculoskeletal MRI, the limited spatial resolution of PET, and the lack of reimbursement for PET for non-oncologic musculoskeletal indications. However, with improvements in PET/CT and PET/MR imaging over the last decade as well as an increased understanding of the pathophysiology of musculoskeletal diseases, there is an emerging potential for PET as a primary or complementary modality in the management of rheumatologic and orthopedic patients...
November 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29123008/reproducibility-of-mr-based-attenuation-maps-in-pet-mri-and-the-impact-on-pet-quantification-in-lung-cancer
#4
Anders Olin, Claes N Ladefoged, Natasha H Langer, Sune H Keller, Johan O Löfgren, Adam E Hansen, Andreas Kjær, Seppo W Langer, Barbara M Fischer, Flemming L Andersen
AIM: Quantitative positron emission tomography/magnetic resonance imaging (PET/MRI) is dependent upon reliable and reproducible MR-based attenuation correction (MR-AC). In this study we evaluated the quality of current vendor-provided thoracic MR-AC maps, and further investigated the reproducibility of these in terms of their impact on fluorodeoxyglucose (FDG)-PET quantification in patients with non-small cell lung cancer (NSCLC). MATERIAL AND METHODS: Eleven patients with inoperable NSCLC underwent two to five thoracic PET/MRI scan-rescan examinations within 22 days...
November 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29121248/fusion-of-positron-emission-tomography-computed-tomography-with-magnetic-resonance-imaging-reveals-hamstring-peritendonitis-in-polymyalgia-rheumatica
#5
Claire E Owen, Aurora M T Poon, Sze Ting Lee, Lee Pheng Yap, Richard B Zwar, Christine M McMenamin, Simon K L Lam, David F L Liew, Kunthi Pathmaraj, Andrew Kemp, Andrew M Scott, Russell R C Buchanan
Objectives: To characterize 18F-fluorodeoxyglucose (18F-FDG) uptake on whole-body PET/CT in PMR, and identify its precise anatomic correlate using MRI. Methods: Patients with newly diagnosed PMR according to the 2012 EULAR/ACR classification criteria were prospectively recruited. Participants with GCA were excluded. A whole-body 18F-FDG PET/CT scan was performed in all untreated patients. Qualitative and semiquantitative [standardized uptake value maximum (SUVmax)] scoring of abnormal 18F-FDG uptake was undertaken...
November 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/29116052/quantitative-performance-evaluation-of-sup-124-sup-i-pet-mri-lesion-dosimetry-in-differentiated-thyroid-cancer
#6
Roel Wierts, Walter Jentzen, Harald H Quick, Hendrik J Wisselink, Ivo N A Pooters, Joachim E Wildberger, Ken Herrmann, Gerrit J Kemerink, Walter H Backes, Felix M Mottaghy
The aim was to investigate the quantitative performance of 124I PET/MRI for pre-therapy lesion dosimetry in differentiated thyroid cancer. Phantom measurements were performed on a PET/MRI system (Biograph mMR, Siemens Healthcare) using 124I and 18F. The PET calibration factor and the influence of radiofrequency coil attenuation were determined using a cylindrical phantom homogeneously filled with radioactivity. The calibration factor was 1.00 ± 0.02 for 18F and 0.88 ± 0.02 for 124I. Near the radiofrequency surface coil an underestimation of less than 5% in radioactivity concentration was observed...
November 8, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29103469/improved-clinical-workflow-for-simultaneous-whole-body-pet-mri-using-high-resolution-caipirinha-accelerated-mr-based-attenuation-correction
#7
Martin T Freitag, Matthias Fenchel, Philipp Bäumer, Thorsten Heußer, Christopher M Rank, Marc Kachelrieß, Daniel Paech, Klaus Kopka, Sebastian Bickelhaupt, Antonia Dimitrakopoulou-Strauss, Klaus Maier-Hein, Ralf Floca, Mark E Ladd, Heinz-Peter Schlemmer, Florian Maier
PURPOSE: To explore the value and reproducibility of a novel magnetic resonance based attenuation correction (MRAC) using a CAIPIRINHA-accelerated T1-weighted Dixon 3D-VIBE sequence for whole-body PET/MRI compared to the clinical standard. METHODS: The PET raw data of 19 patients from clinical routine were reconstructed with standard MRAC (MRACstd) and the novel MRAC (MRACcaipi), a prototype CAIPIRINHA accelerated Dixon 3D-VIBE sequence, both acquired in 19 s/bed position...
November 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29101445/integrated-18-f-fdg-pet-mri-in-breast-cancer-early-prediction-of-response-to-neoadjuvant-chemotherapy
#8
Nariya Cho, Seock-Ah Im, Gi Jeong Cheon, In-Ae Park, Kyung-Hun Lee, Tae-Yong Kim, Young Seon Kim, Bo Ra Kwon, Jung Min Lee, Hoon Young Suh, Koung Jin Suh
PURPOSE: To explore whether integrated (18)F-FDG PET/MRI can be used to predict pathological response to neoadjuvant chemotherapy (NAC) in patients with breast cancer. METHODS: Between November 2014 and April 2016, 26 patients with breast cancer who had received NAC and subsequent surgery were prospectively enrolled. Each patient underwent (18)F-FDG PET/MRI examination before and after the first cycle of NAC. Qualitative MRI parameters, including morphological descriptors and the presence of peritumoral oedema were assessed...
November 4, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29098376/e-edmund-kim-hyung-jun-im-dong-soo-lee-keon-wook-kang-atlas-and-anatomy-of-pet-mri-pet-ct-and-spect-ct-springer-international-publishing-switzerland-2016-isbn-978-3-319-28650-1
#9
Giuseppe Danilo Di Stasio, Luigi Mansi
No abstract text is available yet for this article.
November 2, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29097916/a-method-for-manufacturing-oncological-phantoms-for-the-quantification-of-18f-fdg-pet-and-dw-mri-studies
#10
Francesca Gallivanone, Irene Carne, Matteo Interlenghi, Daniela D'Ambrosio, Maurizia Baldi, Daniele Fantinato, Isabella Castiglioni
The aim of this work was to develop a method to manufacture oncological phantoms for quantitation purposes in 18F-FDG PET and DW-MRI studies. Radioactive and diffusion materials were prepared using a mixture of agarose and sucrose radioactive gels. T2 relaxation and diffusion properties of gels at different sucrose concentrations were evaluated. Realistic oncological lesions were created using 3D-printed plastic molds filled with the gel mixture. Once solidified, gels were extracted from molds and immersed in a low-radioactivity gel simulating normal background tissue...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29097408/-18-f-fdg-pet-mri-in-chronic-sciatica-early-results-revealing-spinal-and-non-spinal-abnormalities
#11
Peter Cipriano, Daehyun Yoon, Harsh Gandhi, Dawn Holley, Dushyant Thakur, Ma Ith, Brian Hargreaves, David Kennedy, Matthew Smuck, Ivan Cheng, Sandip Biswal
Chronic sciatica is a major cause of disability worldwide, but accurate diagnosis of the offending pathology remains challenging. In this report, the feasibility of a fluorodeoxyglucose ((18)F-FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) approach for improved diagnosis of chronic sciatica is presented. Methods:(18)F-FDG PET/MRI was performed on 9 chronic sciatica patients and 5 healthy volunteers. Region-of-interest analysis using maximum standardized uptake values (SUVmax) was performed, and (18)F-FDG uptake in lesions was compared with the corresponding areas in healthy controls...
November 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29097407/comparison-of-pet-ct-with-sequential-pet-mri-using-an-mr-compatible-mobile-pet-system
#12
Ryusuke Nakamoto, Yuji Nakamoto, Takayoshi Ishimori, Yasutaka Fushimi, Aki Kido, Kaori Togashi
Objectives: The current study tested a newly developed flexible PET (positron emission tomography) scanner prototype. This flexible PET (fxPET) system involves dual arc-shaped detectors based on silicon photomultipliers, which are designed to fit existing magnetic resonance (MR) devices, allowing us to get fused PET and MR images by sequential PET scanning. This prospective study sought to evaluate image quality, lesion detection rate, and quantitative values of fxPET in comparison with conventional whole-body (WB) PET images, and to assess the accuracy of registration...
November 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29091934/effects-of-hyperoxia-on-18f-fluoro-misonidazole-brain-uptake-and-tissue-oxygen-tension-following-middle-cerebral-artery-occlusion-in-rodents-pilot-studies
#13
Tim D Fryer, Sohail Ejaz, Ulf Jensen-Kondering, David J Williamson, Sergey Sitnikov, Stephen J Sawiak, Franklin I Aigbirhio, Young T Hong, Jean-Claude Baron
PURPOSE: Mapping brain hypoxia is a major goal for stroke diagnosis, pathophysiology and treatment monitoring. 18F-fluoro-misonidazole (FMISO) positron emission tomography (PET) is the gold standard hypoxia imaging method. Normobaric hyperoxia (NBO) is a promising therapy in acute stroke. In this pilot study, we tested the straightforward hypothesis that NBO would markedly reduce FMISO uptake in ischemic brain in Wistar and spontaneously hypertensive rats (SHRs), two rat strains with distinct vulnerability to brain ischemia, mimicking clinical heterogeneity...
2017: PloS One
https://www.readbyqxmd.com/read/29075832/-68-ga-psma-11-ligand-pet-imaging-in-patients-with-biochemical-recurrence-after-radical-prostatectomy-diagnostic-performance-and-impact-on-therapeutic-decision-making
#14
B Grubmüller, P Baltzer, D D'Andrea, S Korn, A R Haug, M Hacker, K H Grubmüller, G M Goldner, W Wadsak, S Pfaff, J Babich, C Seitz, H Fajkovic, M Susani, P Mazal, G Kramer, S F Shariat, Markus Hartenbach
OBJECTIVE: To evaluate the diagnostic performance of [(68)Ga]Ga-PSMA(HBED-CC) conjugate 11 positron emission tomography (PSMA-PET) in the early detection of metastases in patients with biochemical recurrence (BCR) after radical prostatectomy (RP) for clinically non-metastatic prostate cancer, to compare it to CT/MRI alone and to assess its impact on further therapeutic decisions. MATERIAL AND METHODS: We retrospectively assessed 117 consecutive hormone-naïve BCR patients who had (68)Ga-PSMA 11 PET/CT (n = 46) or PET/MRI (n = 71) between May 2014 and January 2017...
October 26, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29072055/diagnostic-challenges-in-prostate-cancer-and-68ga-psma-pet-imaging-a-game-changer
#15
Maseeh uz Zaman, Nosheen Fatima, Areeba Zaman, Mahwsih Sajid, Unaiza Zaman, Sidra Zaman
Prostate cancer (PC) is the most frequent solid tumor in men and the third most common cause of cancer mortality among men in developed countries. Current imaging modalities like ultrasound (US), computerized tomography (CT), magnetic resonance imaging (MRI) and choline based positron emission (PET) tracing have disappointing sensitivity for detection of nodal metastasis and small tumor recurrence. This poses a diagnostic challenge in staging of intermediate to high risk PC and restaging of patients with biochemical recurrence (PSA >0...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29067775/dual-phase-hybrid-18-f-fluoride-positron-emission-tomography-mri-in-ankylosing-spondylitis-investigating-the-link-between-mri-bone-changes-regional-hyperaemia-and-increased-osteoblastic-activity
#16
Lino M Sawicki, Susanne Lütje, Xenofon Baraliakos, Jürgen Braun, Julian Kirchner, Johannes Boos, Philipp Heusch, Verena Ruhlmann, Ken Herrmann, Lale Umutlu, Harald H Quick, Gerald Antoch, Christian Buchbender
INTRODUCTION: Focal (18) F-Fluoride uptake on blood-pool phase PET represents regional hyperaemia, while it indicates osteoblastic activity on mineralization phase PET. This study investigates the link between regional hyperaemia and osteoblastic activity in inflammatory and chronic lesions of ankylosing spondylitis (AS) of the sacroiliac joints (SIJ) using dual-phase (18) F-Fluoride PET/MRI. METHODS: Thirteen patients (six men, seven women, age: 37 ± 10 years) with active AS prospectively underwent dual-phase (18) F-Fluoride PET/MRI...
October 25, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29064653/prostate-cancer-recurrence-in-vas-deferens-fusion-image-guide-as-an-important-tool-in-dignosis
#17
Leonardo Guedes Moreira Valle, Antônio Rahal, Priscila Mina Falsarella, Juliano Ribeiro de Andrade, Oren Smaletz, Akemi Osawa, Rodrigo Gobbo Garcia
The biochemical recurrence after local treatment for prostate cancer is an often challenging condition of clinical management. The aim of this report is to demonstrate the importance of the association of various imaging methods in the identification and subsequent accurate percutaneous biopsy in patients with recurrence of prostate cancer, especially in unusual sites. An 86 years old male with biochemical recurrence, during radiological investigation a PET-MRI was noted the presence of an asymmetry of the vas deferens with PSMA- 68Ga uptaken, suggesting the recurrence...
October 24, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29063304/applying-amide-proton-transfer-mr-imaging-to-hybrid-brain-pet-mr-concordance-with-gadolinium-enhancement-and-added-value-to-18-f-fdg-pet
#18
Hongzan Sun, Jun Xin, Jinyuan Zhou, Zaiming Lu, Qiyong Guo
PURPOSE: The purpose of this study is to evaluate the diagnostic concordance and metric correlations of amide proton transfer (APT) imaging with gadolinium-enhanced magnetic resonance imaging (MRI) and 2-deoxy-2-[(18)F-]fluoro-D-glucose ([(18)F]FDG) positron emission tomography (PET), using hybrid brain PET/MRI. PROCEDURES: Twenty-one subjects underwent brain gadolinium-enhanced [(18)F]FDG PET/MRI prospectively. Imaging accuracy was compared between unenhanced MRI, MRI with enhancement, APT-weighted (APTW) images, and PET based on six diagnostic criteria...
October 23, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29050469/in-vivo-18-f-ge-179-brain-signal-does-not-show-nmda-specific-modulation-with-drug-challenges-in-rodents-and-nonhuman-primates
#19
Matthias Schoenberger, Frederick A Schroeder, Michael S Placzek, Randall L Carter, Bruce R Rosen, Jacob M Hooker, Christin Y Sander
As one of the major excitatory ion channels in the brain, NMDA receptors have been a leading research target for neuroscientists, physicians, medicinal chemists, and pharmaceutical companies for decades. Molecular imaging of NMDA receptors by means of positron emission tomography (PET) with [(18)F]GE-179 quickly progressed to clinical PET studies, but a thorough understanding of its binding specificity has been missing and has thus limited signal interpretation. Here a preclinical study with [(18)F]GE-179 in rodents and nonhuman primates (NHPs) is presented in an attempt to characterize [(18)F]GE-179 signal specificity...
November 14, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29042474/development-of-a-pet-ct-and-pet-mri-patient-information-films-in-collaboration-with-patient-representatives-previously-treated-for-cancer
#20
Robert Shortman, John Hoath, Tina Osadolor, Pierpaolo Inge, Louise Roper, Jamshed Bomanji, Ashley M Groves
Introduction: PET/MRI and PET CT scanning carries an increased psychological burden for patients which may be improved by effective preparation prior to attendance for the procedure. We aimed to devise an online resource for patient benefit prior to PET/MRI and PET/CT scanning. Methods: With the help of patient representatives' the style and content for two patient information films was reviewed at each stage of the process to explain the patient journey. Results: Two patient information films were produced for patients undergoing PET scanning, Positive feedback from healthcare providers and users was obtained...
October 17, 2017: Journal of Nuclear Medicine Technology
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