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https://www.readbyqxmd.com/read/27498336/activation-of-crhr1-receptors-regulates-social-and-depressive-like-behaviors-and-expression-of-bdnf-and-trkb-in-mesocorticolimbic-regions-following-global-cerebral-ischemia
#1
Patricia Barra de la Tremblaye, Nicolas Narvaez Linares, Sarah Schock, Hélène Plamondon
Increased HPA axis activation and CRH release characterize the brain's response to global cerebral ischemia. Recently, CRH via activation of CRH type 1 receptors (CRHR1) has been shown to regulate Brain Derived Neurotrophic Factor (BDNF) secretion and emotional behavior. The current study investigates the impact of CRHR1 blockade on BDNF/TrkB signaling expression in the mesolimbic circuitry, and social and depressive-like behavior following global ischemia. Adult male Wistar rats were injected with Antalarmin (2μg/μl) or a vehicle 30min prior to 10min global cerebral ischemia (4VO model) or sham occlusion...
August 3, 2016: Experimental Neurology
https://www.readbyqxmd.com/read/27349018/plasma-selenium-levels-in-chronic-cocaine-abuse
#2
Julia Petrova, Victor Manolov, Theodora Kiryakova, Vasil Vasilev, Kamen Tzatchev, Marinov Borislav, Emilova Radoslava
BACKGROUND: Cocaine abuse is a significant health problem worldwide. We aim to evaluate the role of selenium in oxidative stress in patients with cocaine related cardio- and cerebrovascular diseases. Selenium is of fundamental importance to human health. It is an essential component of several major metabolic pathways. METHODS: We included 26 patients with chronic cocaine abuse separated into two groups according to duration of intake--from six months up to one year and more than a year, with and without only vascular incidents (TIA, stroke, myocardial infarction), or presence of hypertension...
2016: Clinical Laboratory
https://www.readbyqxmd.com/read/27266223/prevalence-of-diabetic-foot-ulcers-and-risk-classifications-in-type-2-diabetes-mellitus-patients-at-rajavithi-hospital
#3
Veerasak Sarinnapakorn, Thongkum Sunthorntepwarakul, Chaicharn Deerochanawong, Sathit Niramitmahapanya, Navapom Napartivaumnuay
BACKGROUND: Diabetic foot ulcers are a major cause of non-traumatic lower limb amputation in patients with type 2 diabetes. In 2014, the Diabetes Association of Thailand issued new guidelines for classifying type 2 diabetes patients' levels of risk of developing foot ulcers, but no research on the prevalence of type 2 diabetes using these new classification criteria had been performed prior to the current study. OBJECTIVE: To study the prevalence of diabetic foot ulcers overall and in different risk groups in type 2 diabetes mellitus patients in Rajavithi Hospital, and to evaluate risk factors of these groups and correlations with ankle brachial index (ABI) and cardio-ankle vascular index (CAVI)...
February 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/25797514/diving-medicine-in-clinical-practice
#4
REVIEW
Lars Eichhorn, Dieter Leyk
BACKGROUND: Diving is a popular sport, and some recreational divers have medical risk factors. Their health can be endangered by high extracorporeal (ambient) pressure and its many systemic effects. METHODS: We review relevant publications on free (breath-hold) diving, scuba diving, medical evaluation for diving, barotrauma, decompression sickness, and diving with medical risk factors, which were retrieved by a selective search of PubMed. RESULTS: Free diving or scuba diving, even at seemingly innocuous depths, puts considerable stress on the cardio - vascular system, ears, and lungs...
February 27, 2015: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/24348399/multiple-vascular-accidents-including-rupture-of-a-sinus-of-valsalva-aneurysm-a-minor-ischemic-stroke-and-intracranial-arterial-anomaly-in-a-patient-with-systemic-congenital-abnormalities-a-case-report
#5
Masataka Nakajima, Arata Abe, Yasuhiro Nishiyama, Mina Harada-Abe, Akihito Kutsuna, Yuya Goto, Seiji Okubo, Masahiro Mishina, Ken-Ichiro Katsura, Yasuo Katayama
A 39-year-old man with a history of rupture of a sinus of Valsalva aneurysm experienced an ischemic stroke. Although the patient presented left-sided hemiparesis for a week, no abnormal signals were indicated on diffusion-weighted imaging with repeated magnetic resonance scans. Carotid ultrasound and cerebral angiography were conducted, and they revealed hypoplasty of the left internal carotid artery with a low-lying carotid bifurcation at the level of the C6 vertebra. In addition, he was diagnosed with intellectual disabilities, evaluated by the Wechsler Adult Intelligence Scale-III, and congenital velopharyngeal insufficiency...
2013: Case Reports in Neurology
https://www.readbyqxmd.com/read/23979988/long-term-outcomes-and-comparison-after-conventional-coronary-artery-bypass-grafting-for-left-main-disease-between-patients-classified-as-percutaneous-coronary-intervention-recommendation-classes-ii-and-iii
#6
Yasunori Cho, Takahiko Misumi, Shinichiro Shimura, Akira Aki, Hidekazu Furuya, Shigeto Odagiri, Kimiaki Okada, Toshihiko Ueda
OBJECTIVES: We retrospectively analysed long-term outcomes after conventional coronary artery bypass grafting (CABG) between patients having left main (LM) disease who should have been assigned class II and those assigned class III recommendation for percutaneous coronary intervention (PCI) according to the 2010 European Society of Cardiology and the European Association for Cardio-Thoracic Surgery guidelines. METHODS: From January 2000 to December 2009, conventional CABG was routinely employed in 180 consecutive patients with previously untreated and stable LM lesion...
March 2014: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/23755705/-orthostatic-hypotension-2nd-part-epidemiology-complications-and-treatments
#7
M Tyberghein, J-C Philips, J-M Krzesinski, A J Scheen
Orthostatic hypotension (OH) is a rather common phenomenon in clinical practice. It may occur in 5-10 % of normal individuals, but its prevalence increases with age and various pathologies, so that it may rise above 35 % in certain subgroups of patients. OH is associated with various comorbidities, in particular cardio-cerebro-vascular accidents and falls (especially in the elderly), and may even increase mortality. It is, however, difficult to determine whether OH is simply a marker of frailty or whether it is really a risk factor...
April 2013: Revue Médicale de Liège
https://www.readbyqxmd.com/read/23698821/cardio-and-cerebrovascular-ccv-safety-of-once-daily-indacaterol-75-%C3%AE-g-in-the-treatment-of-patients-with-copd
#8
James Donohue, Charles Fogarty, Huilin Hu, Danny McBryan, James Williams
SESSION TYPE: New Insights into COPDPRESENTED ON: Monday, October 22, 2012 at 04:00 PM - 05:30 PMPURPOSE: Clinical efficacy of indacaterol 75 µg qd (IND75), the approved US dose, has been reported [Kerwin, Clin Ther 2011]. Investigations with higher doses report CCV safety over 6 months [Worth, Respir Med 2011] and overall safety up to 1 year [Donohue, Int J COPD 2011]. We report the CCV safety of IND75 in patients with moderate-to-severe COPD.METHODS: Pooled data with IND75 (n=449) and placebo (n=2012 overall) given for up to 3 months were analyzed for CCV adverse events (AEs) and serious AEs (SAEs)...
October 1, 2012: Chest
https://www.readbyqxmd.com/read/23299372/percutaneous-endoscopic-gastrostomy-peg-feeding-in-elderly-people-with-diabetes-resident-in-nursing-homes
#9
R Gadsby
AIM: To investigate the level of percutaneous endoscopic gastrostomy (PEG) feeding in elderly people with diabetes resident in Nursing homes in one area of the U.K., to describe their degree of disability, co-morbidities and to estimate medication costs of these residents. METHODS: The data was collected from a retrospective case notes review of the 75 people with known diabetes who were resident in the 11 Nursing homes in the Coventry Teaching PCT in early 2010...
January 2013: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/23286687/comparison-of-the-rts-and-iss-scores-on-prediction-of-survival-chances-in-multiple-trauma-patients
#10
COMPARATIVE STUDY
G Akhavan Akbari, A Mohammadian
PURPOSE OF THE STUDY: Trauma represents the third cause of death after cardio vascular disease and tumors. Also in Iran, road accidents are one of the leading causes of death. Rapid evaluation of trauma severity and prediction of prognosis and mortality rate and probability of survival and rapid treatment of patients is necessary. One of the useful instruments for this is ISS and RTS scoring systems. This study evaluated 70 multi trauma patients in Fatemi trauma center affiliated to Ardabil University of medical science...
2012: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/23141186/bilateral-stenosis-of-carotid-siphon-in-hutchinson-gilford-progeria-syndrome
#11
Ryo Narazaki, Mika Makimura, Masafumi Sanefuji, Shigeru Fukamachi, Hidetaka Akiyoshi, Hidenori So, Kenichiro Yamamura, Sayoko Doisaki, Seiji Kojima, Kenji Ihara, Toshiro Hara, Shouichi Ohga
Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disease, caused by a de novo mutation of lamin-A gene, LMNA G608G. Accumulation of abnormal lamin-A (progerin) compromises nuclear membrane integrity and results in the accelerated senescence. Affected patients show a typical feature of birdlike face, alopecia, sclerotic skin, loss of subcutaneous fat, and short stature with advancing years. Neonatal scleroderma is the first presentation, although early diagnosis is challenging. The leading cause of death is cardio-/cerebro-vascular accidents associated with atherosclerosis...
August 2013: Brain & Development
https://www.readbyqxmd.com/read/22838272/-means-and-objectives-of-primary-prevention-in-patients-at-high-cardiovascular-risk
#12
Marie-Emmanuelle Sirieix
Since thirty years, cardiovascular mortality fell. That is linked, on the one hand, to an earlier and a more harsh care of the acute accident, and on the other hand, to development of the prophylactic treatment. But cardiovascular diseases stay the main cause of death in the most of western countries, in France in women, and in subjects over 65 years. That's why it is necessary to detect people with a high cardio-vascular risk before any complications so that they can be treated earlier and with an intensive mode...
June 2012: La Revue du Praticien
https://www.readbyqxmd.com/read/22168066/-the-structure-of-emergency-calls-of-the-intensive-care-team-depending-on-age-and-gender-of-patients-appealed-for-urgent-medical-aid
#13
N I Bolotnikova
It is established that in 2008 in examined patients' sampling aged from 15 to 59 years, 47.2% consisted the group of suddenly ill and received urgent medical aid. The patients with cardio-vascular diseases consisted 17.1%, nervous diseases - 11.4%, respiratory diseases - 6.2%, digestion system diseases - 5.5%, urogenital system diseases - 2.4%, mental illnesses and behavior disorders - 2.9%, musculoskeletal and connective tissue diseases - 1.8%, endocrine system diseases, diet and metabolic disorders - 1.0%...
July 2011: Problemy Sot︠s︡ialʹnoĭ Gigieny, Zdravookhranenii︠a︡ i Istorii Medit︠s︡iny
https://www.readbyqxmd.com/read/22076895/-the-causes-of-death-of-the-women-of-childbearing-age-at-the-hospitals-of-sfax
#14
Jihen Djedidi Trabelsi, Sourour Yaich Kammoun, Mohamed Abderraouf Karray, Habib Feki, Mondher Kassis, Jamel Damak
AIM: To study the principal causes of death of the women dead at an âge ranging between 15 and 49 years old and having been hospitalized in a public medical structures of the gouvernorat of Sfax. METHODS: Retrospective study concerning all the included deaths between 1999 and 2007. RESULTS: The study was related to 728 deaths, which correspond to an average of 80.88 deaths FAR per year. Public highway accidents were the major cause of death (83 cases, 11...
October 2011: La Tunisie Médicale
https://www.readbyqxmd.com/read/21992890/neuromuscular-electrical-stimulation-as-a-possible-means-to-prevent-muscle-tissue-wasting-in-artificially-ventilated-and-sedated-patients-in-the-intensive-care-unit-a-pilot-study
#15
Raf L J Meesen, Paul Dendale, Koen Cuypers, Jan Berger, Ann Hermans, Herbert Thijs, Oron Levin
OBJECTIVE: The aim of this study was to explore if electrical stimulation could prevent muscle atrophy. MATERIAL AND METHODS: Patients were hospitalized for postoperative coronary artery bypass graftin, chronic obstructive pulmonary disease, ventilatory failure, or acute cerebro-vascular accident, and were divided into an intervention group or a control group. The intervention group underwent daily 30 minute training with an intermittent neuromuscular electrical stimulation applied to the right quadriceps muscle...
October 2010: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/21520628/-the-state-of-immunity-in-the-liquidators-of-consequences-of-the-chernobyl-accident-with-cardio-vascular-diseases
#16
A A Timoshevskiĭ, N M Kalinina, A N Grebeniuk
The purpose of the work was research and functional reserves immunity in participants in the Chernobyl with cardiovascular disease. A Clinical Lab 49 men aged 44 to 52 years with diseases of the cardiovascular system, participated in the Chernobyl nuclear power plant in 1986 to 1988. As control used data 33 patients with similar pathology, and 16 healthy men. Researched the total number of white blood cells, lymphocytes and transfusions, the absolute number and relative CD4+ and CD8+, CD 16, CD20+, CD95+ lymphocytes peripheral blood, number mononuclear, synthesizing IL-1beta, TNF-alpha, INF-alpha, IL-4, the content of lipids and proteins, the activity of alkaline phosphatase and mieloperoksidazy in neutrophils...
January 2011: Radiatsionnaia Biologiia, Radioecologiia
https://www.readbyqxmd.com/read/21265118/-analysis-of-structural-and-functional-indices-of-the-children-hearts-with-isolated-abnormal-chords-of-the-left-ventricle-and-who-were-born-to-parents-irradiated-during-the-chernobyl-accident
#17
V H Kondrashova, T V Kondratova, L P Sheĭko, V Iu Vdovenko, N S Kondrashova
156 children of the main group, born to parents irradiated in the result of Chernobyl disaster have been involved in the study. These children were identified with isolated abnormal chords of the left ventricle (AHLV) according the results of Doppler echocardiography. 39 practically healthy children and 24 children of the nosology control group have also been observed. Threshold quantity of AHLV were determined in 33 children, main group, (subgroup Ia), sub-threshold--in 123 children (subgroup I(B)). The children of the control group with threshold quantity of AHLV were found with decreased adaptation capacity of the cardio-vascular system through shifts in dynamics and energetics of the heart contraction...
April 2010: Likars'ka Sprava
https://www.readbyqxmd.com/read/20576370/forensic-and-police-identification-of-x-bodies-a-6-years-french-experience
#18
S Cavard, J C Alvarez, P De Mazancourt, F Tilotta, P Brousseau, G Lorin de la Grandmaison, P Charlier
The identification of X bodies is an everyday preoccupation in forensic pathology. This retrospective analysis studied all methods of identification and characteristics of unidentified bodies arrived in the Department of Forensic Medicine and Pathology (University Hospital R. Poincaré, Garches, France) during a 6-years period (2003-2009). The aim was to determine the identification methods used during all the forensic investigations, but also to study causes and manner of death in this sample of the population...
January 30, 2011: Forensic Science International
https://www.readbyqxmd.com/read/20525447/carotid-plaques-in-patients-with-long-term-lupus-nephritis
#19
Beniamina Gallelli, Larry Burdick, Silvana Quaglini, Giovanni Banfi, Cristina Novembrino, Fabrizia Bamonti, Piergiorgio Messa, Gabriella Moroni
OBJECTIVES: To evaluate the prevalence of carotid plaques in patients with long-term lupus nephritis (LN). METHODS: Intima-media thickness (IMT) and carotid plaques were evaluated with ultrasound in 75 patients after a follow-up of LN of 158+/-106 months and in 75 sex -and age-matched controls. Traditional and non-traditional atherosclerotic risks factors were also tested. RESULTS: IMT was not different between LN patients and controls, but 18% of LN patients had carotid plaques in comparison to 2...
May 2010: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/20437886/-identification-of-the-most-common-problems-and-mistakes-in-the-medical-certification-of-inability-to-work-for-disability-pension-provision-based-on-the-expertise-carried-out-by-the-out-patient-clinic-of-occupational-diseases-nofer-institute-of-occupational
#20
Ewa Wagrowska-Koski, Marcin Rybacki
BACKGROUND: The definition of "inability to work" and principles of medical certification of disabilities, determining the entitlement to an ill-health pension provision are regulated by law. However, the term ,,"inability to work" is not precisely defined and the standards of its assessment are not accurately formulated. This refers not only to the term "loosing ability to work to considerable degree", but also to the criteria of occupational qualifications. OBJECTIVES: The aim of this study was to identify the most common problems and mistakes in the medical certification that entitles to disability pension provision...
2010: Medycyna Pracy
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