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Celia Clemente de Arriba, Miguel Angel Alobera Gracia, Paulo G Coelho, Rodrigo Neiva, Dennis P Tarnow, Mariano Del Canto Pingarron, Soledad Aguado-Henche
Porous tantalum trabecular-structured metal (PTTM) has been applied to titanium orthopedic and dental implants. This study evaluated the healing pattern of bone growth into experimental PTTM cylinders (N = 24; 3.0 × 5.0 mm) implanted in the partially edentulous jaws of 23 healthy volunteers divided into four groups. Six PTTM cylinders per group were explanted, prepared, and analyzed histologically/metrically after 2, 3, 6, and 12 weeks of submerged healing. PTTM implant osseoincorporation resulted from the formation of an osteogenic tissue network that over the course of 12 weeks resulted in vascular bone volume levels in PTTM that are comparable to clinically observed mean trabecular volumes in edentulous posterior jaws...
March 7, 2018: International Journal of Periodontics & Restorative Dentistry
J Y Liu, F Chen, Y J Ge, L Wei, S X Pan, H L Feng
OBJECTIVE: To evaluate the influence of the rough surface of dental implants prepared by selective laser melting (SLM) on early bone healing around titanium implants. METHODS: A total of sixteen titanium implants were involved in our research, of which eight implants were prepared by SLM (TIXOS Cylindrical, Leader-Novaxa, Milan, Italy; 3.3 mm×10 mm, internal hex) and the other eight were sandblasted, large-grit and acid-etched (SLA) implants (IMPLUS Cylindrical, Leader-Novaxa, Milan, Italy; 3...
February 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Su A Park, Hyo-Jung Lee, Keun-Suh Kim, Sang Jin Lee, Jung-Tae Lee, Sung-Yeol Kim, Na-Hee Chang, Shin-Young Park
Insufficient bone volume is one of the major challenges encountered by dentists after dental implant placement. This study aimed to evaluate the efficacy of a customized three-dimensional polycaprolactone (3D PCL) scaffold implant fabricated with a 3D bio-printing system to facilitate rapid alveolar bone regeneration. Saddle-type bone defects were surgically created on the healed site after extracting premolars from the mandibles of four beagle dogs. The defects were radiologically examined using computed tomography for designing a customized 3D PCL scaffold block to fit the defect site...
February 4, 2018: Materials
Sergio Alexandre Gehrke, Leticia Pérez-Díaz, Berenice Anina Dedavid
BACKGROUND: New manufacturing methods was developed to improve the tissues integration with the titanium alloy pieces. OBJECTIVE: The present in vitro study was to assess the resistance and fracture mode after applied a quasi-static compressive force on the two dental implants manufactured by direct metal laser sintering. MATERIALS AND METHODS: Twenty dental implants manufactured by direct metal laser sintering, using titanium alloy (Ti-6Al-4V) granules in two designs (n = 10 per group): Conventional dental implant (group Imp1) two-piece implant design, where the surgical implant and prosthetic abutment are two separate components and, the one-piece implant (group Imp2), where the surgical implant and prosthetic abutment are one integral piece...
January 30, 2018: Clinical Implant Dentistry and related Research
Kouji Ohta, Misato Tada, Yoshiaki Ninomiya, Hiroki Kato, Fumi Ishida, Hitoshi Abekura, Kazuhiro Tsuga, Masaaki Takechi
Autogenous block bone grafting as treatment for alveolar ridge atrophy has various disadvantages, including a limited availability of sufficiently sized and shaped grafts, donor site morbidity and resorption of the grafted bone. As a result, interconnected porous hydroxyapatite ceramic (IP-CHA) materials with high porosity have been developed and used successfully in orthopedic cases. To the best of the author's knowledge, this is the first report of clinical application of an IP-CHA block for onlay grafting for implant treatment in a patient with horizontal alveolar atrophy...
December 2017: Experimental and Therapeutic Medicine
Isadora S Deschamps, Gabriel L Magrin, Ricardo S Magini, Márcio C Fredel, Cesar A M Benfatti, Júlio C M Souza
Objectives: After tooth loss, dimensional alterations on the alveolar bone ridge can occur that can negatively affect the placement of dental implants. The purpose of this study was to evaluate the synthesis, and mechanical properties of β-tricalcium phosphate (β-TCP) scaffolds coated with bioabsorbable polymers, namely, collagen and poly (D, L-lactic acid) (PDLLA). Materials and Methods: β-TCP powder was obtained by reactive milling and then characterized by X-ray diffraction and scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM/EDS)...
October 2017: European Journal of Dentistry
Dinesh M Morkhade, Vishwanath S Nande, Umesh V Barabde, Arun T Patil, Siddheshwar B Joshi
OBJECTIVE: In this study, PEGylated rosin derivatives (PRDs) namely D1 and D2 were synthesized and evaluated for their application to produce sustained-release antibacterial films containing sparfloxacin for periodontitis. SIGNIFICANCE: PRDs are biodegradable and biocompatible, and therefore sustained-release dental implant of PRD-sparfloxacin can provide an effectual treatment for periodontitis. METHODS: Films were produced by solvent casting technique and characterized for morphology, swelling-index, in-vitro degradation and drug release kinetics...
December 25, 2017: Drug Development and Industrial Pharmacy
Haffsah Iqbal, Moazzam Ali, Rabia Zeeshan, Zeeshan Mutahir, Farasat Iqbal, Muhammad Azhar Hayat Nawaz, Lubna Shahzadi, Aqif Anwar Chaudhry, Muhammad Yar, Shifang Luan, Ather Farooq Khan, Ihtesham-Ur Rehman
Alveolar bone loss is associated with infections and its augmentation is a pre-requisite for the success of dental implants. In present study, we aim to develop and evaluate novel freeze dried doxycycline loaded chitosan (CS)/hydroxyapatite (HA) spongy scaffolds where hydroxypropylmethyl cellulose (HPMC) was added as a crosslinker. Scaffolds displayed compressive strength of 14MPa/cm3 and 0.34 as elastic response. The interconnected pore diameter was 41-273μm, favorably provided the template supporting cells and transport...
December 1, 2017: Colloids and Surfaces. B, Biointerfaces
Jin Whan Lee, Hai Bo Wen, Prabhu Gubbi, Georgios E Romanos
AIM: This study evaluated new bone formation activities and trabecular bone microarchitecture within the highly porous region of Trabecular Metal™ Dental Implants (TM) and between the threads of Tapered Screw-Vent® Dental Implants (TSV) in fresh canine extraction sockets. MATERIALS AND METHODS: Eight partially edentulated dogs received four implants (4.1 mmD × 13 mmL) bilaterally in mandibular fresh extraction sockets (32 TM, 32 TSV implants), and allowed to heal for 2, 4, 8, and 12 weeks...
October 2, 2017: Clinical Oral Implants Research
Waruna Lakmal Dissanayaka, Chengfei Zhang
Creating an optimal microenvironment that supports angiogenesis, cell-cell cross talk, cell migration, and differentiation is crucial for pulp/dentin regeneration. It was shown that dental stem cells being seeded onto a scaffold and transplanted in vivo could give rise to a new tissue similar to that of the native pulp. However, the unique structure of the tooth with a pulp space encased within hard dentin allows only a single blood supply from a small apical opening located at the apex of the root canals...
September 2017: Journal of Endodontics
Hsueh-Chuan Hsu, Shih-Ching Wu, Shih-Kuang Hsu, Yi-Hang Liao, Wen-Fu Ho
BACKGROUND: As titanium (Ti) alloys are bioinert, various chemically-modified Ti surface has been developed to promote bioactivity and bone ingrowth. OBJECTIVE: In this study, various post treatments (water aging, hydrothermal, and heat treatments) were applied to NaOH-treated Ti-5Si to improve its bioactivity. METHODS: The bioactivity of surface-modified Ti-5Si was access by using the apatite formation ability of Ti-5Si surfaces soaking in a simulated body fluid (SBF)...
2017: Bio-medical Materials and Engineering
Zdenka Fohlerova, Alexander Mozalev
Nanostructuring of biomaterials is used to create an appropriate interfacial layer that promotes stable cellular adhesion, proliferation, and differentiation on orthopedic and dental implants. Here, we synthesize self-organized arrays of composite-oxide nano-mounds through anodizing Al/Ta bilayers sputtered on substrates to cover the "missing" smallest size range of 10-40 nm for structuring an advanced inorganic biomaterial-Al2 O3 -doped Ta2 O5 films. The osteoblast-like cells appear to be able to recognize the finest differences in the film nano-morphologies...
August 24, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Elena García-Gareta, Jia Hua, Alodia Orera, Nupur Kohli, Jonathan C Knowles, Gordon W Blunn
Titanium and its alloys or tantalum (Ta) are materials used in orthopaedic and dental implants due to their excellent mechanical properties and biocompatibility. However, their bioactivity and osteoconductivity is low. With a view to improving these materials bioactivity we hypothesised that the surface of Ta and TiAl6V4 can be functionalised with biomimetic, amorphous nano-sized calcium-phosphate (CaP) apatite-like deposits, instead of creating uniform coatings, which can lead to flaking, delamination and poor adherence...
August 23, 2017: Biomedical Materials
Ge Feng, Yan Wu, Yu Yong, Lan Huang, Shu An, Bo Hu, Jun Luo, Jinlin Song
OBJECTIVE: In this study, we constructed a composite by combining the human dental follicle cell sheet and a manual drilled porous decalcified dentin matrix that was used to construct ectopic tissue-engineered periodontal ligament-like tissues in renal capsules of nude mice. MATERIALS AND METHODS: Human dental follicle cells were harvested from human lower third molars and then embedded into a temperature-sensitive culture dish. These cells were then placed into frozen porous decalcified dentin matrix sheets and induced by 50 g/ml ascorbic acid...
August 16, 2017: Oral Diseases
Do-Gyoon Kim, Yong-Hoon Jeong, Hua-Hong Chien, Amanda M Agnew, Jin Whan Lee, Hai Bo Wen
BACKGROUND: Primary stability of a dental implant system is an essential factor to maintain its long-term success. Thus, the objective of this study was to examine whether primary stability is different between threaded and porous dental implant systems placed in artificial bone blocks and human cadaveric mandibular bone. MATERIALS AND METHODS: Forty-two threaded and 42 highly porous dental implants were placed in artificial polyurethane bone foams with 7 different thicknesses (3...
August 5, 2017: Clinical Biomechanics
Paweł Kubasiewicz-Ross, Marzena Dominiak, Tomasz Gedrange, Ute U Botzenhart
The authors present the contemporary state of knowledge concerning alternative materials for dental implantology. First of all, factors influencing osseointegration are stated. The most important factors seem to be the type of implant surface. Among the numerous parameters describing them, the most important are: average roughness and porous density. Some studies proved that materials with comparable surface roughness provide similar osseointegration. In modern implantology titanium is the material still considered as a "gold standard"...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
M F F A Hamidi, W S W Harun, M Samykano, S A C Ghani, Z Ghazalli, F Ahmad, A B Sulong
Biocompatible metals have been revolutionizing the biomedical field, predominantly in human implant applications, where these metals widely used as a substitute to or as function restoration of degenerated tissues or organs. Powder metallurgy techniques, in specific the metal injection moulding (MIM) process, have been employed for the fabrication of controlled porous structures used for dental and orthopaedic surgical implants. The porous metal implant allows bony tissue ingrowth on the implant surface, thereby enhancing fixation and recovery...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Kazuya Doi, Takayasu Kubo, Shiho Kajihara, Yusuke Makihara, Hiroshi Oue, Yoshifumi Oki, Vittoria Perrotti, Adriano Piattelli, Yasumasa Akagawa, Kazuhiro Tsuga
The aim of this study was to evaluate the stability of implant/interconnected porous calcium hydroxyapatite complex (implant/IPCHA-complex) under functional loading. Implant/IP-CHA-complexes were placed into the mandibles of four Beagle-Labrador hybrid dogs (complex-group). On the other side, an implant was placed directly (control-group). To subject the loading, the animals were fed a hard diet throughout the loading phase of 5 months. The implant stability quotients (ISQs) and bone implant contact (BIC), and histological evaluations were performed...
September 26, 2017: Dental Materials Journal
Ravikumar Ramakrishnaiah, Abdulaziz Abdullah Al Kheraif, Ashfaq Mohammad, Darshan Devang Divakar, Sunil Babu Kotha, Sree Lalita Celur, Mohamed I Hashem, Pekka K Vallittu, Ihtesham Ur Rehman
The current study was aimed to fabricate customized root form dental implant using additive manufacturing technique for the replacement of missing teeth. The root form dental implant was designed using Geomagic™ and Magics™, the designed implant was directly manufactured by layering technique using ARCAM A2™ electron beam melting system by employing medical grade Ti-6Al-4V alloy powder. Furthermore, the fabricated implant was characterized in terms of certain clinically important parameters such as surface microstructure, surface topography, chemical purity and internal porosity...
May 2017: Saudi Journal of Biological Sciences
Lavanya Ajay Sharma, Robert M Love, Mohammad A Ali, Ajay Sharma, Soraia Macari, Avadhoot Avadhani, George J Dias
BACKGROUND: Keratin has shown promising outcomes as a biomaterial due to its inherent bioactivity, biocompatibility and regenerative effects. The effect of keratin on repair and regeneration of dental tissues has never been studied before. Current therapies to treat pulp tissues involve its replacement with inert, synthetic materials that do not have a proper biological function, leading to failure and tooth loss. This study aimed to develop a biocompatible keratin hydrogel (KH) suitable for pulp therapies...
July 27, 2017: Journal of Applied Biomaterials & Functional Materials
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