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https://www.readbyqxmd.com/read/28575965/a-review-of-biocompatible-metal-injection-moulding-process-parameters-for-biomedical-applications
#1
REVIEW
M F F A Hamidi, W S W Harun, M Samykano, S A C Ghani, Z Ghazalli, F Ahmad, A B Sulong
Biocompatible metals have been revolutionizing the biomedical field, predominantly in human implant applications, where these metals widely used as a substitute to or as function restoration of degenerated tissues or organs. Powder metallurgy techniques, in specific the metal injection moulding (MIM) process, have been employed for the fabrication of controlled porous structures used for dental and orthopaedic surgical implants. The porous metal implant allows bony tissue ingrowth on the implant surface, thereby enhancing fixation and recovery...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28566674/a-stability-evaluation-of-a-novel-titanium-dental-implant-interconnected-porous-hydroxyapatite-complex-under-functional-loading-conditions
#2
Kazuya Doi, Takayasu Kubo, Shiho Kajihara, Yusuke Makihara, Hiroshi Oue, Yoshifumi Oki, Vittoria Perrotti, Adriano Piattelli, Yasumasa Akagawa, Kazuhiro Tsuga
The aim of this study was to evaluate the stability of implant/interconnected porous calcium hydroxyapatite complex (implant/IPCHA-complex) under functional loading. Implant/IP-CHA-complexes were placed into the mandibles of four Beagle-Labrador hybrid dogs (complex-group). On the other side, an implant was placed directly (control-group). To subject the loading, the animals were fed a hard diet throughout the loading phase of 5 months. The implant stability quotients (ISQs) and bone implant contact (BIC), and histological evaluations were performed...
May 30, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28490947/preliminary-fabrication-and-characterization-of-electron-beam-melted-ti-6al-4v-customized-dental-implant
#3
Ravikumar Ramakrishnaiah, Abdulaziz Abdullah Al Kheraif, Ashfaq Mohammad, Darshan Devang Divakar, Sunil Babu Kotha, Sree Lalita Celur, Mohamed I Hashem, Pekka K Vallittu, Ihtesham Ur Rehman
The current study was aimed to fabricate customized root form dental implant using additive manufacturing technique for the replacement of missing teeth. The root form dental implant was designed using Geomagic™ and Magics™, the designed implant was directly manufactured by layering technique using ARCAM A2™ electron beam melting system by employing medical grade Ti-6Al-4V alloy powder. Furthermore, the fabricated implant was characterized in terms of certain clinically important parameters such as surface microstructure, surface topography, chemical purity and internal porosity...
May 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28430345/healing-response-of-rat-pulp-treated-with-an-injectable-keratin-hydrogel
#4
Lavanya Ajay Sharma, Robert M Love, Mohammad A Ali, Ajay Sharma, Soraia Macari, Avadhoot Avadhani, George J Dias
BACKGROUND: Keratin has shown promising outcomes as a biomaterial due to its inherent bioactivity, biocompatibility and regenerative effects. The effect of keratin on repair and regeneration of dental tissues has never been studied before. Current therapies to treat pulp tissues involve its replacement with inert, synthetic materials that do not have a proper biological function, leading to failure and tooth loss. This study aimed to develop a biocompatible keratin hydrogel (KH) suitable for pulp therapies...
April 20, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28350007/laser-beam-melting-3d-printing-of-ti6al4v-based-porous-structured-dental-implants-fabrication-biocompatibility-analysis-and-photoelastic-study
#5
Fei Yang, Chen Chen, QianRong Zhou, YiMing Gong, RuiXue Li, ChiChi Li, Florian Klämpfl, Sebastian Freund, XingWen Wu, Yang Sun, Xiang Li, Michael Schmidt, Duan Ma, YouCheng Yu
Fabricating Ti alloy based dental implants with defined porous scaffold structure is a promising strategy for improving the osteoinduction of implants. In this study, we use Laser Beam Melting (LBM) 3D printing technique to fabricate porous Ti6Al4V dental implant prototypes with three controlled pore sizes (200, 350 and 500 μm). The mechanical stress distribution in the surrounding bone tissue is characterized by photoelastography and associated finite element simulation. For in-vitro studies, experiments on implants' biocompatibility and osteogenic capability are conducted to evaluate the cellular response correlated to the porous structure...
March 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28296644/multiscale-porous-titanium-surfaces-via-a-two-step-etching-process-for-improved-mechanical-and-biological-performance
#6
Tae-Sik Jang, Hyun-Do Jung, Sungwon Kim, Byeong-Seok Moon, Jaeuk Baek, Cheonil Park, Juha Song, Hyoun-Ee Kim
Titanium (Ti)-based dental implants with multiscale surface topography have attracted great attention as a promising approach to enhance fixation and long-term stability of the implants, through the synergistic effect of nano- and microscale surface roughness, for accelerated bone regeneration and improved mechanical interlocking. However, structural integrity and mechanical stability of the multiscale roughened Ti surface under deformation need to be considered because significant deformation of dental implants is often induced during the surgical operation...
March 15, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28256366/bone-morphogenetic-protein-2-loaded-poly-d-l-lactide-co-glycolide-microspheres-enhance-osteogenic-potential-of-gelatin-hydroxyapatite-%C3%AE-tricalcium-phosphate-cryogel-composite-for-alveolar-ridge-augmentation
#7
Hao-Chieh Chang, Connie Yang, Fang Feng, Feng-Huei Lin, Chi-Hwa Wang, Po-Chun Chang
BACKGROUND/PURPOSE: Sufficient bony support is essential to ensure the success of dental implant osseointegration. However, the reconstruction of vertical ridge deficiencies is still a major challenge for dental implants. This study introduced a novel treatment strategy by infusing poly(D,L-lactide-co-glycolide) (PLGA) microspheres encapsulating bone morphogenetic protein-2 (BMP-2) within a gelatin/hydroxyapatite/β-tricalcium phosphate (gelatin/HA/β-TCP) cryogel composite to facilitate supra-alveolar ridge augmentation...
February 27, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28215503/biomaterial-shell-bending-with-3d-printed-templates-in-vertical-and-alveolar-ridge-augmentation-a-technical-note
#8
Florian G Draenert, Florian Gebhart, Gergo Mitov, Andreas Neff
OBJECTIVES: Alveolar ridge and vertical augmentations are challenging procedures in dental implantology. Even material blocks with an interconnecting porous system are never completely resorbed. Shell techniques combined with autologous bone chips are therefore the gold standard. Using biopolymers for these techniques is well documented. We applied three-dimensional (3-D) techniques to create an individualized bending model for the adjustment of a plane biopolymer membrane made of polylactide...
January 4, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28128898/tri-layered-nanocomposite-hydrogel-scaffold-for-the-concurrent-regeneration-of-cementum-periodontal-ligament-and-alveolar-bone
#9
S Sowmya, Ullas Mony, P Jayachandran, S Reshma, R Arun Kumar, H Arzate, Shantikumar V Nair, R Jayakumar
A tri-layered scaffolding approach is adopted for the complete and concurrent regeneration of hard tissues-cementum and alveolar bone-and soft tissue-the periodontal ligament (PDL)-at a periodontal defect site. The porous tri-layered nanocomposite hydrogel scaffold is composed of chitin-poly(lactic-co-glycolic acid) (PLGA)/nanobioactive glass ceramic (nBGC)/cementum protein 1 as the cementum layer, chitin-PLGA/fibroblast growth factor 2 as the PDL layer, and chitin-PLGA/nBGC/platelet-rich plasma derived growth factors as the alveolar bone layer...
January 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28094241/gelatin-freeze-casting-of-biomimetic-titanium-alloy-with-anisotropic-and-gradient-pore-structure
#10
Lei Zhang, Ronan Le Coz-Botrel, Charlotte Beddoes, Terje Sjöström, Bo Su
Titanium is a material commonly used for dental and orthopaedic implants. However, due to large differences in properties between the titanium metal and the natural bone, stress shielding has been observed in the surrounding area, resulting in bone atrophy, and thus has raised concerns of the use of this material. Ideally implant materials should possess similar properties to the surrounding tissues in order to distribute the load as the joint would naturally, while also possessing a similar porous structure to the bone to enable interaction with the surrounding material...
January 17, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28076651/controlled-release-of-chlorhexidine-from-a-mesoporous-silica-containing-macroporous-titanium-dental-implant-prevents-microbial-biofilm-formation
#11
K De Cremer, A Braem, E Gerits, K De Brucker, K Vandamme, J A Martens, J Michiels, J Vleugels, B P Cammue, K Thevissen
Roughened surfaces are increasingly being used for dental implant applications as the enlarged contact area improves bone cell anchorage, thereby facilitating osseointegration. However, the additional surface area also entails a higher risk for the development of biofilm associated infections, an etiologic factor for many dental ailments, including peri-implantitis. To overcome this problem, we designed a dental implant composed of a porous titanium-silica (Ti/SiO2) composite material and containing an internal reservoir that can be loaded with antimicrobial compounds...
January 11, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28073074/tribocorrosion-behavior-of-bio-functionalized-highly-porous-titanium
#12
F Toptan, A C Alves, A M P Pinto, P Ponthiaux
Titanium and its alloys are widely used in orthopedic and dental implants, however, some major clinical concerns such as poor wear resistance, lack of bioactivity, and bone resorption due to stress shielding are yet to be overcome. In order to improve these drawbacks, highly porous Ti samples having functionalized surfaces were developed by powder metallurgy with space holder technique followed by anodic treatment. Tribocorrosion tests were performed in 9g/L NaCl solution using a unidirectional pin-on-disc tribometer under 3N normal load, 1Hz frequency and 4mm track diameter...
January 4, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27987682/porous-magnesium-based-scaffolds-for-tissue-engineering
#13
REVIEW
Mostafa Yazdimamaghani, Mehdi Razavi, Daryoosh Vashaee, Keyvan Moharamzadeh, Aldo R Boccaccini, Lobat Tayebi
Significant amount of research efforts have been dedicated to the development of scaffolds for tissue engineering. Although at present most of the studies are focused on non-load bearing scaffolds, many scaffolds have also been investigated for hard tissue repair. In particular, metallic scaffolds are being studied for hard tissue engineering due to their suitable mechanical properties. Several biocompatible metallic materials such as stainless steels, cobalt alloys, titanium alloys, tantalum, nitinol and magnesium alloys have been commonly employed as implants in orthopedic and dental treatments...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27788123/osseointegration-of-three-dimensional-designed-titanium-implants-manufactured-by-selective-laser-melting
#14
Algabri Shaoki, Jia-Yun Xu, Haipeng Sun, Xian-Shuai Chen, Jianglin Ouyang, Xiu-Mei Zhuang, Fei-Long Deng
The selective laser melting (SLM) technique is a recent additive manufacturing (AM) technique. Several studies have reported success in the SLM-based production of biocompatible orthopaedic implants and three-dimensional bone defect constructs. In this study, we evaluated the surface properties and biocompatibility of an SLM titanium implant in vitro and compared them with those of a machined (MA) titanium control surface. In addition, we evaluated the osseointegration capability of the SLM implants in vivo and compared it with those of MA and Nobel-speedy (Nobel-S) implants...
October 27, 2016: Biofabrication
https://www.readbyqxmd.com/read/27782497/biomimetic-coatings-enhance-tribocorrosion-behavior-and-cell-responses-of-commercially-pure-titanium-surfaces
#15
Isabella da Silva Vieira Marques, Maria Fernanda Alfaro, Miki Taketomi Saito, Nilson Cristino da Cruz, Christos Takoudis, Richard Landers, Marcelo Ferraz Mesquita, Francisco Humberto Nociti Junior, Mathew T Mathew, Cortino Sukotjo, Valentim Adelino Ricardo Barão
Biofunctionalized surfaces for implants are currently receiving much attention in the health care sector. Our aims were (1) to create bioactive Ti-coatings doped with Ca, P, Si, and Ag produced by microarc oxidation (MAO) to improve the surface properties of biomedical implants, (2) to investigate the TiO2 layer stability under wear and corrosion, and (3) to evaluate human mesenchymal stem cells (hMSCs) responses cultured on the modified surfaces. Tribocorrosion and cell experiments were performed following the MAO treatment...
August 11, 2016: Biointerphases
https://www.readbyqxmd.com/read/27726837/-micro-porous-titanium-implants-in-orthognathic-facial-recontouring
#16
REVIEW
Jean-Baptiste Charrier, Nathan Moreau
INTRODUCTION: Facial symmetry has always been a longstanding objective of orthognathic surgery. Patients that present significant facial asymmetry desire functional dental occlusion but also seek to enhance their facial esthetics. In that regard, different surgical techniques have been proposed to enhance facial recontouring. MATERIALS AND METHODS: Through a clinical case report and a literature review, this article explores the use of allopastic microporous titanium implants in volumetric corrections of the face...
September 2016: L' Orthodontie Française
https://www.readbyqxmd.com/read/27612843/titanium-dental-implant-surfaces-obtained-by-anodic-spark-deposition-from-the-past-to-the-future
#17
REVIEW
Milena R Kaluđerović, Joachim P Schreckenbach, Hans-Ludwig Graf
Commercial titanium-based dental implants are obtained applying various methods such as machining, acid etching, anodization, plasma spraying, grit blasting or combination techniques yielding materials with smooth or micro-roughened surfaces. Those techniques are used to optimize the surface properties and to maximize biocompatibility and bioactivity with bone tissue. Present review is focused on the material surfaces obtained by anodic spark deposition (ASD). From the early 1980s till present, the results of numerous studies have shown that anodically oxidized surfaces with different dopants express a positive effect on osteoblasts behavior in vitro and osseointegration in vivo...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27556202/osseointegration-aspects-of-placed-implant-in-bone-reconstruction-with-newly-developed-block-type-interconnected-porous-calcium-hydroxyapatite
#18
Kazuya Doi, Takayasu Kubo, Yusuke Makihara, Hiroshi Oue, Koji Morita, Yoshifumi Oki, Shiho Kajihara, Kazuhiro Tsuga
OBJECTIVES: The purpose of this study was to evaluate the osseointegration of dental implant in bone reconstructions with interconnected porous calcium hydroxyapatite (IP-CHA). MATERIAL AND METHODS: The IP-CHA cylinders (D; 4.3 mm, H; 10.0 mm) were placed into bone sockets in each side of the femurs of four male dogs. The IP-CHA on the right side was a 24-week sample. Twelve weeks after placement, a titanium implant was placed into a socket that was prepared in half of the placed IP-CHA cylinder on the right side...
July 2016: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/27514370/biomimetic-coatings-enhance-tribocorrosion-behavior-and-cell-responses-of-commercially-pure-titanium-surfaces
#19
Isabella da Silva Vieira Marques, Maria Fernanda Alfaro, Miki Taketomi Saito, Nilson Cristino da Cruz, Christos Takoudis, Richard Landers, Marcelo Ferraz Mesquita, Francisco Humberto Nociti Junior, Mathew T Mathew, Cortino Sukotjo, Valentim Adelino Ricardo Barão
Biofunctionalized surfaces for implants are currently receiving much attention in the health care sector. Our aims were (1) to create bioactive Ti-coatings doped with Ca, P, Si, and Ag produced by microarc oxidation (MAO) to improve the surface properties of biomedical implants, (2) to investigate the TiO2 layer stability under wear and corrosion, and (3) to evaluate human mesenchymal stem cells (hMSCs) responses cultured on the modified surfaces. Tribocorrosion and cell experiments were performed following the MAO treatment...
2016: Biointerphases
https://www.readbyqxmd.com/read/27501817/laser-sintered-constructs-with-bio-inspired-porosity-and-surface-micro-nano-roughness-enhance-mesenchymal-stem-cell-differentiation-and-matrix-mineralization-in-vitro
#20
Alice Cheng, David J Cohen, Barbara D Boyan, Zvi Schwartz
Direct metal laser sintering can produce porous Ti-6Al-4V orthopedic and dental implants. The process requires reduced resources and time and can provide greater structural control than machine manufacturing. Implants in bone are colonized by mesenchymal stem cells (MSCs), which can differentiate into osteoblasts and contribute to osseointegration. This study examined osteoblast differentiation and matrix mineralization of human MSCs cultured on laser-sintered Ti-6Al-4V constructs with varying porosity and at different time scales...
August 8, 2016: Calcified Tissue International
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