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https://www.readbyqxmd.com/read/29285093/application-of-interconnected-porous-hydroxyapatite-ceramic-block-for-onlay-block-bone-grafting-in-implant-treatment-a-case-report
#1
Kouji Ohta, Misato Tada, Yoshiaki Ninomiya, Hiroki Kato, Fumi Ishida, Hitoshi Abekura, Kazuhiro Tsuga, Masaaki Takechi
Autogenous block bone grafting as treatment for alveolar ridge atrophy has various disadvantages, including a limited availability of sufficiently sized and shaped grafts, donor site morbidity and resorption of the grafted bone. As a result, interconnected porous hydroxyapatite ceramic (IP-CHA) materials with high porosity have been developed and used successfully in orthopedic cases. To the best of the author's knowledge, this is the first report of clinical application of an IP-CHA block for onlay grafting for implant treatment in a patient with horizontal alveolar atrophy...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29279677/on-the-synthesis-and-characterization-of-%C3%AE-tricalcium-phosphate-scaffolds-coated-with-collagen-or-poly-d-l-lactic-acid-for-alveolar-bone-augmentation
#2
Isadora S Deschamps, Gabriel L Magrin, Ricardo S Magini, Márcio C Fredel, Cesar A M Benfatti, Júlio C M Souza
Objectives: After tooth loss, dimensional alterations on the alveolar bone ridge can occur that can negatively affect the placement of dental implants. The purpose of this study was to evaluate the synthesis, and mechanical properties of β-tricalcium phosphate (β-TCP) scaffolds coated with bioabsorbable polymers, namely, collagen and poly (D, L-lactic acid) (PDLLA). Materials and Methods: β-TCP powder was obtained by reactive milling and then characterized by X-ray diffraction and scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM/EDS)...
October 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/29277118/design-and-evaluation-of-dental-films-of-pegylated-rosin-derivatives-containing-sparfloxacin-for-periodontitis
#3
Dinesh M Morkhade, Vishwanath S Nande, Umesh V Barabde, Arun T Patil, Siddheshwar B Joshi
OBJECTIVE: In this study, PEGylated rosin derivatives (PRDs) namely D1 and D2 were synthesized and evaluated for their application to produce sustained-release antibacterial films containing sparfloxacin for periodontitis. SIGNIFICANCE: PRDs are biodegradable and biocompatible, and therefore sustained-release dental implant of PRD-sparfloxacin can provide an effectual treatment for periodontitis. METHODS: Films were produced by solvent casting technique and characterized for morphology, swelling-index, in-vitro degradation and drug release kinetics...
December 25, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29024920/chitosan-hydroxyapatite-ha-hydroxypropylmethyl-cellulose-hpmc-spongy-scaffolds-synthesis-and-evaluation-as-potential-alveolar-bone-substitutes
#4
Haffsah Iqbal, Moazzam Ali, Rabia Zeeshan, Zeeshan Mutahir, Farasat Iqbal, Muhammad Azhar Hayat Nawaz, Lubna Shahzadi, Aqif Anwar Chaudhry, Muhammad Yar, Shifang Luan, Ather Farooq Khan, Ihtesham-Ur Rehman
Alveolar bone loss is associated with infections and its augmentation is a pre-requisite for the success of dental implants. In present study, we aim to develop and evaluate novel freeze dried doxycycline loaded chitosan (CS)/hydroxyapatite (HA) spongy scaffolds where hydroxypropylmethyl cellulose (HPMC) was added as a crosslinker. Scaffolds displayed compressive strength of 14MPa/cm(3) and 0.34 as elastic response. The interconnected pore diameter was 41-273μm, favorably provided the template supporting cells and transport...
October 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28971532/new-bone-formation-and-trabecular-bone-microarchitecture-of-highly-porous-tantalum-compared-to-titanium-implant-threads-a-pilot-canine-study
#5
Jin Whan Lee, Hai Bo Wen, Prabhu Gubbi, Georgios E Romanos
AIM: This study evaluated new bone formation activities and trabecular bone microarchitecture within the highly porous region of Trabecular Metal™ Dental Implants (TM) and between the threads of Tapered Screw-Vent® Dental Implants (TSV) in fresh canine extraction sockets. MATERIALS AND METHODS: Eight partially edentulated dogs received four implants (4.1 mmD × 13 mmL) bilaterally in mandibular fresh extraction sockets (32 TM, 32 TSV implants), and allowed to heal for 2, 4, 8, and 12 weeks...
October 2, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28962902/the-role-of-vasculature-engineering-in-dental-pulp-regeneration
#6
Waruna Lakmal Dissanayaka, Chengfei Zhang
Creating an optimal microenvironment that supports angiogenesis, cell-cell cross talk, cell migration, and differentiation is crucial for pulp/dentin regeneration. It was shown that dental stem cells being seeded onto a scaffold and transplanted in vivo could give rise to a new tissue similar to that of the native pulp. However, the unique structure of the tooth with a pulp space encased within hard dentin allows only a single blood supply from a small apical opening located at the apex of the root canals...
September 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28854492/effect-of-different-post-treatments-on-the-bioactivity-of-alkali-treated-ti-5si-alloy
#7
Hsueh-Chuan Hsu, Shih-Ching Wu, Shih-Kuang Hsu, Yi-Hang Liao, Wen-Fu Ho
BACKGROUND: As titanium (Ti) alloys are bioinert, various chemically-modified Ti surface has been developed to promote bioactivity and bone ingrowth. OBJECTIVE: In this study, various post treatments (water aging, hydrothermal, and heat treatments) were applied to NaOH-treated Ti-5Si to improve its bioactivity. METHODS: The bioactivity of surface-modified Ti-5Si was access by using the apatite formation ability of Ti-5Si surfaces soaking in a simulated body fluid (SBF)...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28837748/tuning-the-response-of-osteoblast-like-cells-to-the-porous-alumina-assisted-mixed-oxide-nano-mound-arrays
#8
Zdenka Fohlerova, Alexander Mozalev
Nanostructuring of biomaterials is used to create an appropriate interfacial layer that promotes stable cellular adhesion, proliferation, and differentiation on orthopedic and dental implants. Here, we synthesize self-organized arrays of composite-oxide nano-mounds through anodizing Al/Ta bilayers sputtered on substrates to cover the "missing" smallest size range of 10-40 nm for structuring an advanced inorganic biomaterial-Al2 O3 -doped Ta2 O5 films. The osteoblast-like cells appear to be able to recognize the finest differences in the film nano-morphologies...
August 24, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28832345/biomimetic-surface-functionalization-of-clinically-relevant-metals-used-as-orthopaedic-and-dental-implants
#9
Elena García-Gareta, Jia Hua, Alodia Orera, Nupur Kohli, Jonathan C Knowles, Gordon W Blunn
Titanium and its alloys or tantalum (Ta) are materials used in orthopaedic and dental implants due to their excellent mechanical properties and biocompatibility. However, their bioactivity and osteoconductivity is low. With a view to improving these materials bioactivity we hypothesised that the surface of Ta and TiAl6V4 can be functionalised with biomimetic, amorphous nano-sized calcium-phosphate (CaP) apatite-like deposits, instead of creating uniform coatings, which can lead to flaking, delamination and poor adherence...
August 23, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28815884/periodontal-ligament-like-tissue-regeneration-with-drilled-porous-decalcified-dentin%C3%A2-matrix-sheet-composite
#10
Ge Feng, Yan Wu, Yu Yong, Lan Huang, Shu An, Bo Hu, Jun Luo, Jinlin Song
OBJECTIVE: In this study, we constructed a composite by combining the human dental follicle cell sheet and a manual drilled porous decalcified dentin matrix that was used to construct ectopic tissue-engineered periodontal ligament-like tissues in renal capsules of nude mice. MATERIALS AND METHODS: Human dental follicle cells were harvested from human lower third molars and then embedded into a temperature-sensitive culture dish. These cells were then placed into frozen porous decalcified dentin matrix sheets and induced by 50 g/ml ascorbic acid...
August 16, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28806591/immediate-mechanical-stability-of-threaded-and-porous-implant-systems
#11
Do-Gyoon Kim, Yong-Hoon Jeong, Hua-Hong Chien, Amanda M Agnew, Jin Whan Lee, Hai Bo Wen
BACKGROUND: Primary stability of a dental implant system is an essential factor to maintain its long-term success. Thus, the objective of this study was to examine whether primary stability is different between threaded and porous dental implant systems placed in artificial bone blocks and human cadaveric mandibular bone. MATERIALS AND METHODS: Forty-two threaded and 42 highly porous dental implants were placed in artificial polyurethane bone foams with 7 different thicknesses (3...
August 5, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28791830/zirconium-the-material-of-the-future-in-modern-implantology
#12
REVIEW
Paweł Kubasiewicz-Ross, Marzena Dominiak, Tomasz Gedrange, Ute U Botzenhart
The authors present the contemporary state of knowledge concerning alternative materials for dental implantology. First of all, factors influencing osseointegration are stated. The most important factors seem to be the type of implant surface. Among the numerous parameters describing them, the most important are: average roughness and porous density. Some studies proved that materials with comparable surface roughness provide similar osseointegration. In modern implantology titanium is the material still considered as a "gold standard"...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28575965/a-review-of-biocompatible-metal-injection-moulding-process-parameters-for-biomedical-applications
#13
REVIEW
M F F A Hamidi, W S W Harun, M Samykano, S A C Ghani, Z Ghazalli, F Ahmad, A B Sulong
Biocompatible metals have been revolutionizing the biomedical field, predominantly in human implant applications, where these metals widely used as a substitute to or as function restoration of degenerated tissues or organs. Powder metallurgy techniques, in specific the metal injection moulding (MIM) process, have been employed for the fabrication of controlled porous structures used for dental and orthopaedic surgical implants. The porous metal implant allows bony tissue ingrowth on the implant surface, thereby enhancing fixation and recovery...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28566674/a-stability-evaluation-of-a-novel-titanium-dental-implant-interconnected-porous-hydroxyapatite-complex-under-functional-loading-conditions
#14
Kazuya Doi, Takayasu Kubo, Shiho Kajihara, Yusuke Makihara, Hiroshi Oue, Yoshifumi Oki, Vittoria Perrotti, Adriano Piattelli, Yasumasa Akagawa, Kazuhiro Tsuga
The aim of this study was to evaluate the stability of implant/interconnected porous calcium hydroxyapatite complex (implant/IPCHA-complex) under functional loading. Implant/IP-CHA-complexes were placed into the mandibles of four Beagle-Labrador hybrid dogs (complex-group). On the other side, an implant was placed directly (control-group). To subject the loading, the animals were fed a hard diet throughout the loading phase of 5 months. The implant stability quotients (ISQs) and bone implant contact (BIC), and histological evaluations were performed...
September 26, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28490947/preliminary-fabrication-and-characterization-of-electron-beam-melted-ti-6al-4v-customized-dental-implant
#15
Ravikumar Ramakrishnaiah, Abdulaziz Abdullah Al Kheraif, Ashfaq Mohammad, Darshan Devang Divakar, Sunil Babu Kotha, Sree Lalita Celur, Mohamed I Hashem, Pekka K Vallittu, Ihtesham Ur Rehman
The current study was aimed to fabricate customized root form dental implant using additive manufacturing technique for the replacement of missing teeth. The root form dental implant was designed using Geomagic™ and Magics™, the designed implant was directly manufactured by layering technique using ARCAM A2™ electron beam melting system by employing medical grade Ti-6Al-4V alloy powder. Furthermore, the fabricated implant was characterized in terms of certain clinically important parameters such as surface microstructure, surface topography, chemical purity and internal porosity...
May 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28430345/healing-response-of-rat-pulp-treated-with-an-injectable-keratin-hydrogel
#16
Lavanya Ajay Sharma, Robert M Love, Mohammad A Ali, Ajay Sharma, Soraia Macari, Avadhoot Avadhani, George J Dias
BACKGROUND: Keratin has shown promising outcomes as a biomaterial due to its inherent bioactivity, biocompatibility and regenerative effects. The effect of keratin on repair and regeneration of dental tissues has never been studied before. Current therapies to treat pulp tissues involve its replacement with inert, synthetic materials that do not have a proper biological function, leading to failure and tooth loss. This study aimed to develop a biocompatible keratin hydrogel (KH) suitable for pulp therapies...
April 20, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28350007/laser-beam-melting-3d-printing-of-ti6al4v-based-porous-structured-dental-implants-fabrication-biocompatibility-analysis-and-photoelastic-study
#17
Fei Yang, Chen Chen, QianRong Zhou, YiMing Gong, RuiXue Li, ChiChi Li, Florian Klämpfl, Sebastian Freund, XingWen Wu, Yang Sun, Xiang Li, Michael Schmidt, Duan Ma, YouCheng Yu
Fabricating Ti alloy based dental implants with defined porous scaffold structure is a promising strategy for improving the osteoinduction of implants. In this study, we use Laser Beam Melting (LBM) 3D printing technique to fabricate porous Ti6Al4V dental implant prototypes with three controlled pore sizes (200, 350 and 500 μm). The mechanical stress distribution in the surrounding bone tissue is characterized by photoelastography and associated finite element simulation. For in-vitro studies, experiments on implants' biocompatibility and osteogenic capability are conducted to evaluate the cellular response correlated to the porous structure...
March 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28296644/multiscale-porous-titanium-surfaces-via-a-two-step-etching-process-for-improved-mechanical-and-biological-performance
#18
Tae-Sik Jang, Hyun-Do Jung, Sungwon Kim, Byeong-Seok Moon, Jaeuk Baek, Cheonil Park, Juha Song, Hyoun-Ee Kim
Titanium (Ti)-based dental implants with multiscale surface topography have attracted great attention as a promising approach to enhance fixation and long-term stability of the implants, through the synergistic effect of nano- and microscale surface roughness, for accelerated bone regeneration and improved mechanical interlocking. However, structural integrity and mechanical stability of the multiscale roughened Ti surface under deformation need to be considered because significant deformation of dental implants is often induced during the surgical operation...
March 15, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28256366/bone-morphogenetic-protein-2-loaded-poly-d-l-lactide-co-glycolide-microspheres-enhance-osteogenic-potential-of-gelatin-hydroxyapatite-%C3%AE-tricalcium-phosphate-cryogel-composite-for-alveolar-ridge-augmentation
#19
Hao-Chieh Chang, Connie Yang, Fang Feng, Feng-Huei Lin, Chi-Hwa Wang, Po-Chun Chang
BACKGROUND/PURPOSE: Sufficient bony support is essential to ensure the success of dental implant osseointegration. However, the reconstruction of vertical ridge deficiencies is still a major challenge for dental implants. This study introduced a novel treatment strategy by infusing poly(D,L-lactide-co-glycolide) (PLGA) microspheres encapsulating bone morphogenetic protein-2 (BMP-2) within a gelatin/hydroxyapatite/β-tricalcium phosphate (gelatin/HA/β-TCP) cryogel composite to facilitate supra-alveolar ridge augmentation...
February 27, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28215503/biomaterial-shell-bending-with-3d-printed-templates-in-vertical-and-alveolar-ridge-augmentation-a-technical-note
#20
Florian G Draenert, Florian Gebhart, Gergo Mitov, Andreas Neff
OBJECTIVES: Alveolar ridge and vertical augmentations are challenging procedures in dental implantology. Even material blocks with an interconnecting porous system are never completely resorbed. Shell techniques combined with autologous bone chips are therefore the gold standard. Using biopolymers for these techniques is well documented. We applied three-dimensional (3-D) techniques to create an individualized bending model for the adjustment of a plane biopolymer membrane made of polylactide...
June 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
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