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Lei Zhang, Ronan Le Coz-Botrel, Charlotte Beddoes, Terje Sjöström, Bo Su
Titanium is a material commonly used for dental and orthopaedic implants. However, due to large differences in properties between the titanium metal and the natural bone, stress shielding has been observed in the surrounding area, resulting in bone atrophy, and thus has raised concerns of the use of this material. Ideally implant materials should possess similar properties to the surrounding tissues in order to distribute the load as the joint would naturally, while also possessing a similar porous structure to the bone to enable interaction with the surrounding material...
January 17, 2017: Biomedical Materials
K De Cremer, A Braem, E Gerits, K De Brucker, K Vandamme, J A Martens, J Michiels, J Vleugels, B P Cammue, K Thevissen
Roughened surfaces are increasingly being used for dental implant applications as the enlarged contact area improves bone cell anchorage, thereby facilitating osseointegration. However, the additional surface area also entails a higher risk for the development of biofilm associated infections, an etiologic factor for many dental ailments, including peri-implantitis. To overcome this problem, we designed a dental implant composed of a porous titanium-silica (Ti/SiO2) composite material and containing an internal reservoir that can be loaded with antimicrobial compounds...
January 11, 2017: European Cells & Materials
F Toptan, A C Alves, A M P Pinto, P Ponthiaux
Titanium and its alloys are widely used in orthopedic and dental implants, however, some major clinical concerns such as poor wear resistance, lack of bioactivity, and bone resorption due to stress shielding are yet to be overcome. In order to improve these drawbacks, highly porous Ti samples having functionalized surfaces were developed by powder metallurgy with space holder technique followed by anodic treatment. Tribocorrosion tests were performed in 9g/L NaCl solution using a unidirectional pin-on-disc tribometer under 3N normal load, 1Hz frequency and 4mm track diameter...
January 4, 2017: Journal of the Mechanical Behavior of Biomedical Materials
Mostafa Yazdimamaghani, Mehdi Razavi, Daryoosh Vashaee, Keyvan Moharamzadeh, Aldo R Boccaccini, Lobat Tayebi
Significant amount of research efforts have been dedicated to the development of scaffolds for tissue engineering. Although at present most of the studies are focused on non-load bearing scaffolds, many scaffolds have also been investigated for hard tissue repair. In particular, metallic scaffolds are being studied for hard tissue engineering due to their suitable mechanical properties. Several biocompatible metallic materials such as stainless steels, cobalt alloys, titanium alloys, tantalum, nitinol and magnesium alloys have been commonly employed as implants in orthopedic and dental treatments...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Algabri Shaoki, Jia-Yun Xu, Haipeng Sun, Xian-Shuai Chen, Jianglin Ouyang, Xiu-Mei Zhuang, Fei-Long Deng
The selective laser melting (SLM) technique is a recent additive manufacturing (AM) technique. Several studies have reported success in the SLM-based production of biocompatible orthopaedic implants and three-dimensional bone defect constructs. In this study, we evaluated the surface properties and biocompatibility of an SLM titanium implant in vitro and compared them with those of a machined (MA) titanium control surface. In addition, we evaluated the osseointegration capability of the SLM implants in vivo and compared it with those of MA and Nobel-speedy (Nobel-S) implants...
October 27, 2016: Biofabrication
Isabella da Silva Vieira Marques, Maria Fernanda Alfaro, Miki Taketomi Saito, Nilson Cristino da Cruz, Christos Takoudis, Richard Landers, Marcelo Ferraz Mesquita, Francisco Humberto Nociti Junior, Mathew T Mathew, Cortino Sukotjo, Valentim Adelino Ricardo Barão
Biofunctionalized surfaces for implants are currently receiving much attention in the health care sector. Our aims were (1) to create bioactive Ti-coatings doped with Ca, P, Si, and Ag produced by microarc oxidation (MAO) to improve the surface properties of biomedical implants, (2) to investigate the TiO2 layer stability under wear and corrosion, and (3) to evaluate human mesenchymal stem cells (hMSCs) responses cultured on the modified surfaces. Tribocorrosion and cell experiments were performed following the MAO treatment...
August 11, 2016: Biointerphases
Jean-Baptiste Charrier, Nathan Moreau
INTRODUCTION: Facial symmetry has always been a longstanding objective of orthognathic surgery. Patients that present significant facial asymmetry desire functional dental occlusion but also seek to enhance their facial esthetics. In that regard, different surgical techniques have been proposed to enhance facial recontouring. MATERIALS AND METHODS: Through a clinical case report and a literature review, this article explores the use of allopastic microporous titanium implants in volumetric corrections of the face...
September 2016: L' Orthodontie Française
Milena R Kaluđerović, Joachim P Schreckenbach, Hans-Ludwig Graf
Commercial titanium-based dental implants are obtained applying various methods such as machining, acid etching, anodization, plasma spraying, grit blasting or combination techniques yielding materials with smooth or micro-roughened surfaces. Those techniques are used to optimize the surface properties and to maximize biocompatibility and bioactivity with bone tissue. Present review is focused on the material surfaces obtained by anodic spark deposition (ASD). From the early 1980s till present, the results of numerous studies have shown that anodically oxidized surfaces with different dopants express a positive effect on osteoblasts behavior in vitro and osseointegration in vivo...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Kazuya Doi, Takayasu Kubo, Yusuke Makihara, Hiroshi Oue, Koji Morita, Yoshifumi Oki, Shiho Kajihara, Kazuhiro Tsuga
OBJECTIVES: The purpose of this study was to evaluate the osseointegration of dental implant in bone reconstructions with interconnected porous calcium hydroxyapatite (IP-CHA). MATERIAL AND METHODS: The IP-CHA cylinders (D; 4.3 mm, H; 10.0 mm) were placed into bone sockets in each side of the femurs of four male dogs. The IP-CHA on the right side was a 24-week sample. Twelve weeks after placement, a titanium implant was placed into a socket that was prepared in half of the placed IP-CHA cylinder on the right side...
July 2016: Journal of Applied Oral Science: Revista FOB
Isabella da Silva Vieira Marques, Maria Fernanda Alfaro, Miki Taketomi Saito, Nilson Cristino da Cruz, Christos Takoudis, Richard Landers, Marcelo Ferraz Mesquita, Francisco Humberto Nociti Junior, Mathew T Mathew, Cortino Sukotjo, Valentim Adelino Ricardo Barão
Biofunctionalized surfaces for implants are currently receiving much attention in the health care sector. Our aims were (1) to create bioactive Ti-coatings doped with Ca, P, Si, and Ag produced by microarc oxidation (MAO) to improve the surface properties of biomedical implants, (2) to investigate the TiO2 layer stability under wear and corrosion, and (3) to evaluate human mesenchymal stem cells (hMSCs) responses cultured on the modified surfaces. Tribocorrosion and cell experiments were performed following the MAO treatment...
2016: Biointerphases
Alice Cheng, David J Cohen, Barbara D Boyan, Zvi Schwartz
Direct metal laser sintering can produce porous Ti-6Al-4V orthopedic and dental implants. The process requires reduced resources and time and can provide greater structural control than machine manufacturing. Implants in bone are colonized by mesenchymal stem cells (MSCs), which can differentiate into osteoblasts and contribute to osseointegration. This study examined osteoblast differentiation and matrix mineralization of human MSCs cultured on laser-sintered Ti-6Al-4V constructs with varying porosity and at different time scales...
August 8, 2016: Calcified Tissue International
Marco Giannelli, Giulia Landini, Fabrizio Materassi, Flaminia Chellini, Alberto Antonelli, Alessia Tani, Sandra Zecchi-Orlandini, Gian Maria Rossolini, Daniele Bani
Effective decontamination of biofilm and bacterial toxins from the surface of dental implants is a yet unresolved issue. This in vitro study aims at providing the experimental basis for possible use of diode laser (λ 808 nm) in the treatment of peri-implantitis. Staphylococcus aureus biofilm was grown for 48 h on titanium discs with porous surface corresponding to the bone-implant interface and then irradiated with a diode laser (λ 808 nm) in noncontact mode with airflow cooling for 1 min using a Ø 600-μm fiber...
November 2016: Lasers in Medical Science
Wei Peng, Liangwei Xu, Jia You, Lihua Fang, Qing Zhang
BACKGROUND: Osseointegration refers to the direct connection between living bone and the surface of a load-bearing artificial implant. Porous implants with well-controlled porosity and pore size can enhance osseointegration. However, until recently implants were produced by machining solid core titanium rods. The aim of this study was to develop a multi-rooted dental implant (MRI) with a connected porous surface structure to facilitate osseointegration. METHODS: MRIs manufactured by selective laser melting (SLM) and commercial implants with resorbable blasting media (RBM)-treated surfaces were inserted into the hind limbs of New Zealand white rabbits...
July 21, 2016: Biomedical Engineering Online
Jingming Zhao, K H Hwang, W S Choi, S J Shin, J K Lee
Titanium as one kind of biomaterials comes in direct contact with the body, making evaluation of biocompatibility an important aspect to biomaterials development. Surface chemistry of titanium plays an important role in osseointegration. Different surface modification alters the surface chemistry and result in different biological response. In this study, three kinds of mixed acid solutions were used to treat Ti specimens to induce Ca-P formation. Following a strong mixed acid activation process, Ca-P coating successfully formed on the Ti surfaces in simulated body fluid...
February 2016: Journal of Nanoscience and Nanotechnology
Qi Wang, Yuqin Qiao, Mengqi Cheng, Guofeng Jiang, Guo He, Yunsu Chen, Xianlong Zhang, Xuanyong Liu
Porous Ti is considered to be an ideal graft material in orthopaedic and dental surgeries due to its similar spatial structures and mechanical properties to cancellous bone. In this work, to overcome the bioinertia of Ti, Ta-implanted entangled porous titanium (EPT) was constructed by plasma immersion ion implantation &deposition (PIII&D) method. Ca-implanted and unimplanted EPTs were investigated as control groups. Although no difference was found in surface topography and mechanical performances, both Ca- and Ta-implanted groups had better effects in promoting MG-63 cell viability, proliferation, differentiation, and mineralization than those of unimplanted group...
2016: Scientific Reports
S V Sirak, E V Shchetinin, A A Sletov
The article discusses the use of porous titanium for subantral augmentation. Experimental study was conducted on 12 yearling rams. Subantral augmentation using porous titanium was performed in 33 patients. In the control group consisting of 14 patients calcium phosphates and bone collagen based agents ("Bio-Оss" and "Collost") were used. In the main and control groups 46 and 32 implant were placed, respectively. Pilot histological and clinical studies proved that the granules of porous titanium are biocompatible with bone tissue, provide the optimal surface microrelief, thus creating good conditions for adhesion, expansion and migration of osteoforming cells, have negligible kinetics of resorption, are porous to ensure effective neovascularization of de novo formed bone tissue...
2016: Stomatologii︠a︡
Georgios E Romanos, Rafael Arcesio Delgado-Ruiz, Danielle Sacks, Josè Luis Calvo-Guirado
OBJECTIVES: The aim of this study was to evaluate the primary, initial stability of Porous Tantalum Trabecular Metal(™) implants (TM) compared with Tapered Screw Vent(®) implants (TSV) with different diameters, inserted in two bone densities. METHODS: A total of 160 implants (80 TM and 80 TSV) with narrow (3.7 mm) and conventional (4.1 mm) diameters and the same length (10 mm) were placed in artificial bone blocks representing bone qualities II and IV. The implant stability was evaluated by insertion torque (IT) and Resonance Frequency Analysis...
February 24, 2016: Clinical Oral Implants Research
Junning Chen, Liangjian Chen, Che-Cheng Chang, Zhongpu Zhang, Wei Li, Michael V Swain, Qing Li
Design of prosthetic implants to ensure rapid and stable osseointegration remains a significant challenge, and continuous efforts have been directed to new implant materials, structures and morphology. This paper aims to develop and characterise a porous titanium dental implant fabricated by metallic powder injection-moulding. The surface morphology of the specimens was firstly examined with a scanning electron microscope (SEM), followed by microscopic computerised tomography (μ-CT) scanning to capture its 3D microscopic features non-destructively...
February 25, 2016: International Journal for Numerical Methods in Biomedical Engineering
Isabella da Silva Vieira Marques, Valentim Adelino Ricardo Barão, Nilson Cristino da Cruz, Judy Chia-Chun Yuan, Marcelo Ferraz Mesquita, Antonio Pedro Ricomini-Filho, Cortino Sukotjo, Mathew T Mathew
The surface characteristics and electrochemical properties of bioactive coatings produced by plasma electrolytic oxidation (PEO) with calcium, phosphorous, silicon and silver on commercially pure titanium were evaluated. PEO treatment produced a porous oxide layer, which improved the surface topography, and enriched the surface chemistry with bioactive elements, responsible for mimicking bone surface. The surfaces with higher calcium concentration presented antibacterial and biocompability properties with better responses for corrosion and barrier properties, due to the presence of rutile crystalline structure...
November 1, 2015: Corrosion Science
Geraldine Koenig, Hayriye Ozcelik, Lisa Haesler, Martina Cihova, Sait Ciftci, Agnes Dupret-Bories, Christian Debry, Martin Stelzle, Philippe Lavalle, Nihal Engin Vrana
UNLABELLED: Porous titanium implants are widely used in dental, orthopaedic and otorhinolaryngology fields to improve implant integration to host tissue. A possible step further to improve the integration with the host is the incorporation of autologous cells in porous titanium structures via cell-laden hydrogels. Fast gelling hydrogels have advantageous properties for in situ applications such as localisation of specific cells and growth factors at a target area without dispersion. The ability to control the cell types in different regions of an implant is important in applications where the target tissue (i) has structural heterogeneity (multiple cell types with a defined spatial configuration with respect to each other); (ii) has physical property gradients essential for its function (such as in the case of osteochondral tissue transition)...
March 2016: Acta Biomaterialia
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