keyword
https://read.qxmd.com/read/38536927/activation-of-endogenous-retroviruses-and-induction-of-viral-mimicry-by-mek1-2-inhibition-in-pancreatic-cancer
#1
JOURNAL ARTICLE
Alice Cortesi, Francesco Gandolfi, Fabiana Arco, Pierluigi Di Chiaro, Emanuele Valli, Sara Polletti, Roberta Noberini, Francesco Gualdrini, Sergio Attanasio, Francesca Citron, I-Lin Ho, Rutvi Shah, Er-Yen Yen, Mara Cetty Spinella, Simona Ronzoni, Simona Rodighiero, Nico Mitro, Tiziana Bonaldi, Serena Ghisletti, Silvia Monticelli, Andrea Viale, Giuseppe Riccardo Diaferia, Gioacchino Natoli
While pancreatic ductal adenocarcinomas (PDACs) are addicted to KRAS-activating mutations, inhibitors of downstream KRAS effectors, such as the MEK1/2 kinase inhibitor trametinib, are devoid of therapeutic effects. However, the extensive rewiring of regulatory circuits driven by the attenuation of the KRAS pathway may induce vulnerabilities of therapeutic relevance. An in-depth molecular analysis of the transcriptional and epigenomic alterations occurring in PDAC cells in the initial hours after MEK1/2 inhibition by trametinib unveiled the induction of endogenous retroviruses (ERVs) escaping epigenetic silencing, leading to the production of double-stranded RNAs and the increased expression of interferon (IFN) genes...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536701/the-milan-score-a-novel-manometric-tool-for-a-more-efficient-diagnosis-of-gastro-esophageal-reflux-disease
#2
JOURNAL ARTICLE
Stefano Siboni, Marco Sozzi, Ivan Kristo, Sara Boveri, Benjamin D Rogers, Nicola De Bortoli, Anthony Hobson, Brian E Louie, Yeong Yeh Lee, Salvatore Tolone, Elisa Marabotto, Pierfrancesco Visaggi, Jordan Haworth, Megan L Ivy, Garrett Greenan, Takahiro Masuda, Roberto Penagini, Benedetta Barcella, Marina Coletta, Dimitrios Theodorou, Tania Triantafyllou, Chiara Facchini, Vincent Tee, Luigi Bonavina, Lorenzo Cusmai, Sebastian F Schoppmann, Edoardo Savarino, Emanuele Asti, C Prakash Gyawali
OBJECTIVE: A definitive diagnosis of gastroesophageal reflux disease (GERD) depends on endoscopic and/or pH-study criteria. However, high resolution manometry (HRM) can identify factors predicting GERD, such as ineffective esophageal motility (IEM), esophago-gastric junction contractile integral (EGJ-CI), evaluating esophagogastric junction (EGJ) type and straight leg raise (SLR) maneuver response. We aimed to build and externally validate a manometric score (Milan Score) to stratify the risk and severity of the disease in patients undergoing HRM for suspected GERD...
March 27, 2024: United European Gastroenterology Journal
https://read.qxmd.com/read/38536503/vacuum-assisted-mini-percutaneous-nephrolithotomy-is-associated-with-lower-rates-of-infectious-complications-compared-to-vacuum-cleaner-procedure-in-patients-at-high-risk-for-infections-a-single-center-experience
#3
JOURNAL ARTICLE
Andrea Marmiroli, Marco Nizzardo, Stefano Paolo Zanetti, Gianpaolo Lucignani, Matteo Turetti, Carlo Silvani, Franco Gadda, Fabrizio Longo, Elisa De Lorenzis, Giancarlo Albo, Andrea Salonia, Emanuele Montanari, Luca Boeri
PURPOSE: To evaluate the impact of vacuum-assisted mini-percutaneous nephrolithotomy (vamPCNL) vs. vacuum-cleaner mPCNL (vcmPCNL) on the rate of postoperative infectious complications in a cohort of patients with high risk factors for infections. METHODS: We retrospectively analysed data from 145 patients who underwent mPCNL between 01/2016 and 12/2022. Patient's demographics, stones characteristics and operative data were collected. vamPCNL and vcmPCNL were performed based on the surgeon's preference...
March 27, 2024: World Journal of Urology
https://read.qxmd.com/read/38536086/frailty-as-a-comprehensive-health-measure-beyond-seizure-control-in-patients-with-epilepsy-a-cross-sectional-study
#4
JOURNAL ARTICLE
Emanuele Cerulli Irelli, Maria S Borioni, Alessandra Morano, Adolfo Mazzeo, Pierludovico Moro, Biagio Orlando, Enrico M Salamone, Luca Giordano, Alessio Petrungaro, Marco Toccaceli Blasi, Anna T Giallonardo, Marco Canevelli, Carlo Di Bonaventura
OBJECTIVE: Due to the high clinical heterogeneity of epilepsy, there is a critical need for novel metrics aimed at capturing its biological and phenotypic complexity. Frailty is increasingly recognized in various medical disciplines as a useful construct to understand differences in susceptibility to adverse outcomes. Here, we develop a frailty index (FI) for patients with epilepsy (PwE) and explore its association with demographic and clinical features. METHODS: In this cross-sectional study, we consecutively enrolled 153 PwE from an outpatient epilepsy clinic...
March 27, 2024: Epilepsia
https://read.qxmd.com/read/38536060/moderate-alcohol-intake-and-reduced-mortality-risk-is-the-j-shaped-curve-flattening
#5
JOURNAL ARTICLE
Fabio Caputo, Andrea Ghiselli, Valentino Patussi, Emanuele Scafato, Gianni Testino
No abstract text is available yet for this article.
March 26, 2024: Minerva Medica
https://read.qxmd.com/read/38535986/remembering-our-friend-jean-philippe-collet-a-giant-in-cardiology-a-gentleman-in-life
#6
JOURNAL ARTICLE
Pierre Sabouret, Emanuele Barbato, Gilles Montalescot, Giuseppe Biondi-Zoccai, Stéphane Manzo-Silberman
No abstract text is available yet for this article.
March 27, 2024: Minerva cardiology and angiology
https://read.qxmd.com/read/38535799/the-mutagenic-plasticity-of-the-cholera-toxin-b-subunit-surface-residues-stability-and-affinity
#7
JOURNAL ARTICLE
Cheuk W Au, Iain Manfield, Michael E Webb, Emanuele Paci, W Bruce Turnbull, James F Ross
Mastering selective molecule trafficking across human cell membranes poses a formidable challenge in healthcare biotechnology while offering the prospect of breakthroughs in drug delivery, gene therapy, and diagnostic imaging. The cholera toxin B-subunit (CTB) has the potential to be a useful cargo transporter for these applications. CTB is a robust protein that is amenable to reengineering for diverse applications; however, protein redesign has mostly focused on modifications of the N- and C-termini of the protein...
March 4, 2024: Toxins
https://read.qxmd.com/read/38535550/concomitant-syndromic-diagnosis-of-mpox-and-other-vesicular-viruses-in-patients-with-skin-and-genital-lesions
#8
JOURNAL ARTICLE
Maria Beatrice Valli, Antonella Vulcano, Martina Rueca, Giulia Matusali, Valentina Mazzotta, Emanuele Nicastri, Enrico Girardi, Carla Fontana, Andrea Antinori, Fabrizio Maggi
The recent multi-country outbreak of the zoonotic monkeypox virus (MPXV) infection in humans without an epidemiological link with endemic areas has raised concerns about the route of transmission. Since the infection spread largely among men who have sex with men who, in most cases, presented primary lesions of the genital and oral mucosa, sexual transmission has been proposed. In the present study, we retrospectively evaluated specimens of vesicular lesions collected from the skin and genital tract of 35 patients (23 positive and 12 negative) presenting at our Institute for monkeypox (mpox) diagnosis by using a novel molecular syndromic vesicular virus panel (VVP) assay...
February 27, 2024: Pathogens
https://read.qxmd.com/read/38535033/pulmonary-adverse-events-in-cancer-immunotherapy-case-studies-of-ct-patterns
#9
JOURNAL ARTICLE
Giorgio Bocchini, Maria Chiara Imperato, Tullio Valente, Salvatore Guarino, Roberta Lieto, Candida Massimo, Emanuele Muto, Federica Romano, Mariano Scaglione, Giacomo Sica, Davide Vitagliano Torre, Salvatore Masala, Marialuisa Bocchino, Gaetano Rea
Immune-checkpoint inhibitors have profoundly changed cancer treatment, improving the prognosis of many oncologic patients. However, despite the good efficacy of these drugs, their mechanism of action, which involves the activation of the immune system, can lead to immune-related adverse events, which may affect almost all organs. Pulmonary adverse events are relatively common, and potentially life-threatening complications may occur. The diagnosis is challenging due to the wide and non-specific spectrum of clinical and radiological manifestations...
March 14, 2024: Diagnostics
https://read.qxmd.com/read/38534590/microscopic-and-macroscopic-characterization-of-hydrogels-based-on-poly-vinyl-alcohol-glutaraldehyde-mixtures-for-fricke-gel-dosimetry
#10
JOURNAL ARTICLE
Silvia Locarno, Paolo Arosio, Francesca Curtoni, Marco Piazzoni, Emanuele Pignoli, Salvatore Gallo
In recent decades, hydrogels have emerged as innovative soft materials with widespread applications in the medical and biomedical fields, including drug delivery, tissue engineering, and gel dosimetry. In this work, a comprehensive study of the macroscopic and microscopic properties of hydrogel matrices based on Poly(vinyl-alcohol) (PVA) chemically crosslinked with Glutaraldehyde (GTA) was reported. Five different kinds of PVAs differing in molecular weight and degree of hydrolysis were considered. The local microscopic organization of the hydrogels was studied through the use of the 1 H nuclear magnetic resonance relaxometry technique...
February 28, 2024: Gels
https://read.qxmd.com/read/38533147/osteopathic-approach-in-the-stimulation-of-the-endocannabinoid-system-a-case-report
#11
Caterina Buonomini, Oliviero Bonetti, Emanuele Novelli
The endocannabinoid system is an important neuromodulatory system responsible for maintaining homeostasis in the biological system. Similarly, the autonomic nervous system is important to control involuntary bodily functions such as thermoregulation, regulation of heart rate and sleep latency. The endocannabinoid system and the autonomic nervous system can be modified by osteopathic manipulative techniques. In this report, we present a case of a 53-year-old patient with comorbidities, habitual cannabis use, and disorders associated with the endocannabinoid system and autonomic nervous system, on whom the cranial technique of the fourth ventricle (CV4) was performed...
February 2024: Curēus
https://read.qxmd.com/read/38533127/decoding-the-historical-tale-covid-19-impact-on-haematological-malignancy-patients-epicovideha-insights-from-2020-to-2022
#12
JOURNAL ARTICLE
Jon Salmanton-García, Francesco Marchesi, Francesca Farina, Barbora Weinbergerová, Federico Itri, Julio Dávila-Valls, Sonia Martín-Pérez, Andreas Glenthøj, Ditte Stampe Hersby, Maria Gomes da Silva, Raquel Nunes Rodrigues, Alberto López-García, Raúl Córdoba, Yavuz M Bilgin, Iker Falces-Romero, Shaimaa El-Ashwah, Ziad Emarah, Caroline Besson, Milena Kohn, Jaap Van Doesum, Emanuele Ammatuna, Monia Marchetti, Jorge Labrador, Giovanni Paolo Maria Zambrotta, Luisa Verga, Ozren Jaksic, Marcio Nucci, Klára Piukovics, Alba Cabirta-Touzón, Moraima Jiménez, Elena Arellano, Ildefonso Espigado, Ola Blennow, Anna Nordlander, Stef Meers, Jens van Praet, Tommaso Francesco Aiello, Carolina Garcia-Vidal, Nicola Fracchiolla, Mariarita Sciumè, Guldane Cengiz Seval, Pavel Žák, Caterina Buquicchio, Carlo Tascini, Stefanie K Gräfe, Martin Schönlein, Tatjana Adžić-Vukičević, Valentina Bonuomo, Chiara Cattaneo, Summiya Nizamuddin, Martin Čerňan, Gaëtan Plantefeve, Romane Prin, Tomas Szotkovski, Graham P Collins, Michelina Dargenio, Verena Petzer, Dominik Wolf, Natasha Čolović, Lucia Prezioso, Toni Valković, Francesco Passamonti, Gustavo-Adolfo Méndez, Uluhan Sili, Antonio Vena, Martina Bavastro, Alessandro Limongelli, Rafael F Duarte, Marie-Pierre Ledoux, Milche Cvetanoski, Zlate Stojanoski, Marina Machado, Josip Batinić, Gabriele Magliano, Monika M Biernat, Nikola Pantić, Christian Bjørn Poulsen, Annarosa Cuccaro, Maria Ilaria Del Principe, Austin Kulasekararaj, Irati Ormazabal-Vélez, Alessandro Busca, Fatih Demirkan, Marriyam Ijaz, Nikolai Klimko, Igor Stoma, Sofya Khostelidi, Noemí Fernández, Ali S Omrani, Rui Bergantim, Nick De Jonge, Guillemette Fouquet, Milan Navrátil, Ghaith Abu-Zeinah, Michail Samarkos, Johan Maertens, Cristina De Ramón, Anna Guidetti, Ferenc Magyari, Tomás José González-López, Tobias Lahmer, Olimpia Finizio, Natasha Ali, László Imre Pinczés, Esperanza Lavilla-Rubira, Alessandra Romano, Maria Merelli, Mario Delia, Maria Calbacho, Joseph Meletiadis, Darko Antić, José-Ángel Hernández-Rivas, Joyce Marques de Almeida, Murtadha Al-Khabori, Martin Hoenigl, Maria Chiara Tisi, Nina Khanna, Aleksandra Barać, Noha Eisa, Roberta Di Blasi, Raphaël Liévin, Carolina Miranda-Castillo, Nathan C Bahr, Sylvain Lamure, Mario Virgilio Papa, Ayel Yahya, Avinash Aujayeb, Jan Novák, Nurettin Erben, María Fernández-Galán, José-María Ribera-Santa Susana, Ikhwan Rinaldi, Rita Fazzi, Monica Piedimonte, Rémy Duléry, Yung Gonzaga, Andrés Soto-Silva, Giuseppe Sapienza, Alexandra Serris, Ľuboš Drgoňa, Ana Groh, Laura Serrano, Eleni Gavriilaki, Athanasios Tragiannidis, Juergen Prattes, Nicola Coppola, Vladimir Otašević, Miloš Mladenović, Mirjana Mitrović, Bojana Mišković, Pavel Jindra, Sofia Zompi, Maria Vittoria Sacchi, Carolin Krekeler, Maria Stefania Infante, Daniel García-Bordallo, Gökçe Melis Çolak, Jiří Mayer, Marietta Nygaard, Michaela Hanáková, Zdeněk Ráčil, Matteo Bonanni, Philipp Koehler, Laman Rahimli, Oliver A Cornely, Livio Pagano
BACKGROUND: The COVID-19 pandemic heightened risks for individuals with hematological malignancies due to compromised immune systems, leading to more severe outcomes and increased mortality. While interventions like vaccines, targeted antivirals, and monoclonal antibodies have been effective for the general population, their benefits for these patients may not be as pronounced. METHODS: The EPICOVIDEHA registry (National Clinical Trials Identifier, NCT04733729) gathers COVID-19 data from hematological malignancy patients since the pandemic's start worldwide...
May 2024: EClinicalMedicine
https://read.qxmd.com/read/38532309/contribution-of-nutritional-lifestyle-and-metabolic-risk-factors-to-parkinson-s-disease
#13
JOURNAL ARTICLE
Nicola Veronese, Andrea Nova, Teresa Fazia, Emilia Riggi, Lin Yang, Laura Piccio, Bo-Huei Huang, Matthew Ahmadi, Mario Barbagallo, Maria Notarnicola, Gianluigi Giannelli, Giovanni De Pergola, Emmanuel Stamatakis, Emanuele Cereda, Luisa Bernardinelli, Luigi Fontana
BACKGROUND: Modifiable risk factors for Parkinson's disease (PD) are poorly known. OBJECTIVES: The aim is to evaluate independent associations of different nutritional components, physical activity, and sedentary behavior and metabolic factors with the risk of PD. METHODS: In this population-based prospective cohort study using the data of the United Kingdom Biobank (from 2006-2010), 502,017 men and women who were free from PD (International Classification of Diseases 10th edition; "G20") at baseline were included...
March 26, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38532048/awake-pronation-with-helmet-cpap-in-early-covid-19-ards-patients-effects-on-respiratory-effort-and-distribution-of-ventilation-assessed-by-eit
#14
JOURNAL ARTICLE
Tommaso Fossali, Martina Locatelli, Riccardo Colombo, Alice Veronese, Beatrice Borghi, Elisabetta Ballone, Antonio Castelli, Roberto Rech, Emanuele Catena, Davide Ottolina
Prone positioning with continuous positive airway pressure (CPAP) is widely used for respiratory support in awake patients with COVID-19-associated acute respiratory failure. We aimed to assess the respiratory mechanics and distribution of ventilation in COVID-19-associated ARDS treated by CPAP in awake prone position. We studied 16 awake COVID-19 patients with moderate-to-severe ARDS. The study protocol consisted of a randomized sequence of supine and prone position with imposed positive end-expiratory pressure (PEEP) of 5 and 10 cmH2 O delivered by helmet CPAP...
March 26, 2024: Internal and Emergency Medicine
https://read.qxmd.com/read/38531857/synergistic-morphology-and-feedback-control-for-traversal-of-unknown-compliant-obstacles-with-aerial-robots
#15
JOURNAL ARTICLE
Emanuele Aucone, Christian Geckeler, Daniele Morra, Lucia Pallottino, Stefano Mintchev
Animals traverse vegetation by direct physical interaction using their entire body to push aside and slide along compliant obstacles. Current drones lack this interaction versatility that stems from synergies between body morphology and feedback control modulated by sensing. Taking inspiration from nature, we show that a task-oriented design allows a drone with a minimalistic controller to traverse obstacles with unknown elastic responses. A discoid sensorized shell allows to establish and sense contacts anywhere along the shell and facilitates sliding along obstacles...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38530603/comparison-of-blood-volume-biofeedback-hemodialysis-and-conventional-hemodialysis-on-cardiovascular-stability-and-blood-pressure-control-in-hemodialysis-patients-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#16
REVIEW
Emanuele Mambelli, Fabio Grandi, Antonio Santoro
BACKGROUND: Despite the improvements in hemodialysis (HD) technology, 20-30% of sessions are still complicated by hypotension or hypotension-related symptoms. Biofeedback systems have proven to reduce the occurrence of such events, but no conclusive findings can lead to wider adoption of these systems. We conducted this systematic review and meta-analysis of randomized clinical trials to establish whether the use of blood volume tracking systems compared to conventional hemodialysis (C-HD) reduces the occurrence of intradialytic hypotension...
March 26, 2024: Journal of Nephrology
https://read.qxmd.com/read/38529971/the-right-way-to-approach-conference-site-selection
#17
COMMENT
Merjan Ozisik, Johan Dellgren, Ezekiel Emanuel
No abstract text is available yet for this article.
April 2024: American Journal of Bioethics: AJOB
https://read.qxmd.com/read/38529696/current-challenges-in-xenotransplantation
#18
JOURNAL ARTICLE
Marta Vadori, Emanuele Cozzi
PURPOSE OF REVIEW: In recent years, the xenotransplantation science has advanced tremendously, with significant strides in both preclinical and clinical research. This review intends to describe the latest cutting-edge progress in knowledge and methodologies developed to overcome potential obstacles that may preclude the translation and successful application of clinical xenotransplantation. RECENT FINDINGS: Preclinical studies have demonstrated that it is now possible to extend beyond two years survival of primate recipients of life saving xenografts...
March 27, 2024: Current Opinion in Organ Transplantation
https://read.qxmd.com/read/38529661/uracil-and-pyridine-containing-hdac-inhibitors-displayed-cytotoxicity-in-colorectal-and-glioblastoma-cancer-stem-cells
#19
JOURNAL ARTICLE
Francesco Fiorentino, Emanuele Fabbrizi, Alessia Raucci, Beatrice Noce, Rossella Fioravanti, Sergio Valente, Chantal Paolini, Ruggero De Maria, Christian Steinkühler, Paola Gallinari, Dante Rotili, Antonello Mai
Cancer stem cells (CSCs) are a niche of highly tumorigenic cells featuring self-renewal, activation of pluripotency genes, multidrug resistance, and ability to cause cancer relapse. Seven HDACi (1-7), showing either hydroxamate or 2'-aminoanilide function, were tested in colorectal cancer (CRC) and glioblastoma multiforme (GBM) CSCs to determine their effects on cell proliferation, H3 acetylation levels and in-cell HDAC activity. Two uracil-based hydroxamates, 5 and 6, which differ in substitution at C5 and C6 positions of the pyrimidine ring, exhibited the greatest cytotoxicity in GBM (5) and CRC (6) CSCs, followed by the pyridine-hydroxamate 2, with 2- to 6-fold higher potency than the positive control SAHA...
March 26, 2024: ChemMedChem
https://read.qxmd.com/read/38529660/prenatal-post-implantation-development-of-collared-peccaries-pecari-tajacu-linnaeus-1758
#20
JOURNAL ARTICLE
Hélio Noberto de Araújo Júnior, Igor Renno Guimarães Lopes, Ana Caroline Freitas Caetano de Sousa, Gleidson Benevides de Oliveira, Radan Elvis Matias de Oliveira, Moisés Dantas Tertulino, Emanuel Lucas Bezerra Rocha, Paulo Ricardo Firmino, Alexsandra Fernandes Pereira, Moacir Franco de Oliveira
Given the importance of information on intrauterine development in diagnosing anomalies in the gestational development of the species for the development of assisted reproduction technologies as well as understanding the autonomy and responsiveness of the newborn, the aim of the present study was to describe the external morphology of collared peccary conceptuses. For this study, two conceptuses were used per gestational age of 25-120 days post-copulation (dpc) and neonates with 145 dpc, totalling 22 animals...
May 2024: Anatomia, Histologia, Embryologia
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