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https://www.readbyqxmd.com/read/29917077/usmg5-ashkenazi-jewish-founder-mutation-impairs-mitochondrial-complex-v-dimerization-and-atp-synthesis
#1
Emanuele Barca, Rebecca D Ganetzky, Prasanth Potluri, Marti Juanola-Falgarona, Xiaowu Gai, Dong Li, Chaim Jalas, Yoel Hirsch, Valentina Emmanuele, Saba Tadesse, Marcello Ziosi, Hasan O Akman, Wendy K Chung, Kurenai Tanji, Elizabeth McCormick, Emily Place, Mark Consugar, Eric A Pierce, Hakon Hakonarson, Douglas C Wallace, Michio Hirano, Marni J Falk
Leigh syndrome is a frequent, heterogeneous pediatric presentation of mitochondrial oxidative phosphorylation (OXPHOS) disease, manifesting with psychomotor retardation and necrotizing lesions in brain deep gray matter. OXPHOS occurs at the inner mitochondrial membrane through the integrated activity of 5 protein complexes, of which complex V (CV) functions in a dimeric form to directly generate adenosine triphosphate (ATP). Mutations in several different structural CV subunits cause Leigh syndrome; however, dimerization defects have not been associated with human disease...
June 18, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29916923/probiotics-and-mucositis
#2
Emanuele Cereda, Marilisa Caraccia, Riccardo Caccialanza
PURPOSE OF REVIEW: To provide an updated perspective on the use of probiotics as adjuvant treatment strategy for patients suffering from or at risk of developing mucositis. RECENT FINDINGS: Studies suggest that oral and intestinal microbiota could be relevant to mucositis development and treatment, but no clear high-risk pattern has been identified and no single probiotic formulation has emerged from human clinical trials for strong recommendation. Promising results from available clinical trials suggest their use in patients with peri-implant mucositis or at risk of anticancer treatment-related oral or intestinal mucositis...
June 18, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29916573/-the-role-of-safety-climate-and-the-relationship-with-job-satisfaction-an-exploratory-study-across-three-different-occupational-contexts
#3
Federica Emanuel, Lara Colombo, Claudio G Cortese, Chiara Ghislieri
OBJECTIVES: This study examined the role of the "safety climate", or the organization's attention to health and safety of workers, and of job demand and resources in relation with job satisfaction. Wellbeing at work is a topic of growing interest, in line with the legislation and the programs on health and safety of workers and management and the evaluation of psychosocial risks. Several studies show that organizational actions concerning health and safety can be an indicator of the attention to employees' wellbeing, even if studies about the relationship between safety climate and some psychosocial outcomes are scant...
December 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29915366/spatio-temporal-modelling-of-weekly-malaria-incidence-in-children-under-5-for-early-epidemic-detection-in-mozambique
#4
Kathryn L Colborn, Emanuele Giorgi, Andrew J Monaghan, Eduardo Gudo, Baltazar Candrinho, Tatiana J Marrufo, James M Colborn
Malaria is a major cause of morbidity and mortality in Mozambique. We present a malaria early warning system (MEWS) for Mozambique informed by seven years of weekly case reports of malaria in children under 5 years of age from 142 districts. A spatio-temporal model was developed based on explanatory climatic variables to map exceedance probabilities, defined as the predictive probability that the relative risk of malaria incidence in a given district for a particular week will exceed a predefined threshold...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29914062/anti-mycobacterium-tuberculosis-activity-of-esters-of-quinoxaline-1-4-di-n-oxide
#5
Isidro Palos, Julieta Luna-Herrera, Edgar E Lara-Ramírez, Alejandra Loera-Piedra, Emanuel Fernández-Ramírez, Ma Guadalupe Aguilera-Arreola, Alma D Paz-González, Antonio Monge, Baojie Wan, Scott Franzblau, Gildardo Rivera
Tuberculosis continues to be a public health problem in the world, and drug resistance has been a major obstacle in its treatment. Quinoxaline 1,4-di- N -oxide has been proposed as a scaffold to design new drugs to combat this disease. To examine the efficacy of this compound, this study evaluates methyl, ethyl, isopropyl, and n-propyl esters of quinoxaline 1,4-di- N -oxide derivatives in vitro against Mycobacterium tuberculosis (pansusceptible and monoresistant strains). Additionally, the inhibitory effect of esters of quinoxaline 1,4-di- N -oxide on M...
June 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29913432/transcriptome-analysis-reveals-novel-insights-into-the-response-of-low-dose-benzo-a-pyrene-exposure-in-male-tilapia
#6
Reyna Cristina Colli-Dula, Xiefan Fang, David Moraga-Amador, Nacira Albornoz-Abud, Roberto Zamora-Bustillos, Ana Conesa, Omar Zapata-Perez, Diego Moreno, Emanuel Hernandez-Nuñez
Despite a wide number of toxicological studies that describe benzo[a]pyrene (BaP) effects, the metabolic mechanisms that underlie these effects in fish are largely unknown. Of great concern is the presence of BaP in aquatic systems, especially those in close proximity to human activity leading to consumption of potentially contaminated foods. BaP is a known carcinogen and it has been reported to have adverse effects on the survival, development and reproduction of fish. The purpose of this study was to investigate if a low dose of BaP can alter genes and key metabolic pathways in the liver and testis in male adult tilapia, and whether these could be associated with biological endpoints disruption...
June 8, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29910806/targeting-the-epidermal-growth-factor-receptor-can-counteract-the-inhibition-of-natural-killer-cell-function-exerted-by-colorectal-tumor-associated-fibroblasts
#7
Delfina Costa, Roberta Venè, Roberto Benelli, Emanuele Romairone, Stefano Scabini, Silvia Catellani, Barbara Rebesco, Luca Mastracci, Federica Grillo, Simona Minghelli, Fabrizio Loiacono, Maria Raffaella Zocchi, Alessandro Poggi
Mesenchymal stromal cells (MSC) present in the tumor microenvironment [usually named tumor-associated fibroblasts (TAF)] can exert immunosuppressive effects on T and natural killer (NK) lymphocytes, favoring tumor immune escape. We have analyzed this mechanism in colorectal carcinoma (CRC) and found that co-culture of NK cells with TAF can prevent the IL-2-mediated NKG2D upregulation. This leads to the impairment of NKG2D-mediated recognition of CRC cells, sparing the NK cell activation through DNAM1 or FcγRIIIA (CD16)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29910605/role-of-etelcalcetide-in-the-management-of-secondary-hyperparathyroidism-in-hemodialysis-patients-a-review-on-current-data-and-place-in-therapy
#8
REVIEW
Claudia Friedl, Emanuel Zitt
Secondary hyperparathyroidism (sHPT) is a frequently occurring severe complication of advanced kidney disease. Its clinical consequences include extraskeletal vascular and valvular calcifications, changes in bone metabolism resulting in renal osteodystrophy, and an increased risk of cardiovascular morbidity and mortality. Calcimimetics are a cornerstone of parathyroid hormone (PTH)-lowering therapy, as confirmed by the recently updated 2017 Kidney Disease: Improving Global Outcomes chronic kidney disease - mineral and bone disorder clinical practice guidelines...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29910545/medication-errors-in-the-emergency-department-knowledge-attitude-behavior-and-training-needs-of-nurses
#9
Emanuele Di Simone, Noemi Giannetta, Flavia Auddino, Antonio Cicotto, Deborah Grilli, Marco Di Muzio
Aim: The aim was to describe which elements of nurses' knowledge, training needs, behavior, and attitude can prevent Medication errors (Acronym MEs) in the emergency department during all steps of the administration of intravenous (IV) medications. Methods: An anonymous questionnaire made up of 43 items has been drafted and delivered to a sample of 103 nurses of a university hospital in Rome. The study has been supported by specific literature review. Results: Majority of the sample (94%) answered that topics related to the preparation and administration of IV medications were covered during the basic course while 63...
May 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29908368/tag-synthesis-and-storage-under-osmotic-stress-a-requirement-for-preserving-membrane-homeostasis-in-renal-cells
#10
Karen Weber, Cecilia Casali, Virginia Gaveglio, Susana Pasquaré, Emanuel Morel Gómez, Leandro Parra, Luciana Erjavec, Cecilia Perazzo, María C Fernández Tome
Hyperosmolarity is a controversial signal for renal cells. It can induce cell stress or differentiation and both require an active lipid metabolism. We showed that hyperosmolarity upregulates phospholipid (PL) de novo synthesis in renal cells. PL synthesis requires fatty acids (FA), usually stored as triglycerides (TAG). PL and TAG de novo synthesis utilize the same initial biosynthetic route: sn-glycerol 3P (G3P) → phosphatidic acid (PA) → diacylglycerol (DAG). In the present work, we evaluate how such pathway contributes to PL and TAG synthesis in renal cells subjected to hyperosmolarity...
June 13, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29907919/discontinuation-of-hormone-therapy-for-elderly-breast-cancer-patients-after-hypofractionated-whole-breast-radiotherapy
#11
Michela Dispinzieri, Eliana La Rocca, Elisabetta Meneghini, Alba Fiorentino, Laura Lozza, Serena Di Cosimo, Massimiliano Gennaro, Vito Cosentino, Milena Sant, Emanuele Pignoli, Riccardo Valdagni, Francesca Bonfantini, Maria Carmen De Santis
The purpose of the study was to examine adherence to hormone therapy (HT) in elderly breast cancer patients (≥ 65 years old) treated with hypofractionated radiotherapy. We analyzed data on 550 ER-positive breast cancer patients given hypofractionated whole-breast radiotherapy from June 2009 to September 2016. Baseline comorbidities considered in the hypertension-augmented Charlson Comorbidity Index (hCCI) were retrospectively retrieved. Total hCCI scores were classified as no comorbidity (hCCI = 0), low burden of comorbidity (hCCI = 1), and high burden of comorbidity (hCCI ≥ 2)...
June 16, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29907870/synergistic-activation-of-pro-inflammatory-type-2-cd8-t-lymphocytes-by-lipid-mediators-in-severe-eosinophilic-asthma
#12
Bart Hilvering, Timothy S C Hinks, Linda Stöger, Emanuele Marchi, Maryam Salimi, Rahul Shrimanker, Wei Liu, Wentao Chen, Jian Luo, Simei Go, Timothy Powell, Jennifer Cane, Samantha Thulborn, Ayako Kurioka, Tianqi Leng, Jamie Matthews, Clare Connolly, Catherine Borg, Mona Bafadhel, Christian B Willberg, Adaikalavan Ramasamy, Ratko Djukanović, Graham Ogg, Ian D Pavord, Paul Klenerman, Luzheng Xue
Human type-2 CD8+ T cells are a cell population with potentially important roles in allergic disease. We investigated this in the context of severe asthma with persistent airway eosinophilia-a phenotype associated with high exacerbation risk and responsiveness to type-2 cytokine-targeted therapies. In two independent cohorts we show that, in contrast to Th2 cells, type-2 cytokine-secreting CD8+ CRTH2+ (Tc2) cells are enriched in blood and airways in severe eosinophilic asthma. Concentrations of prostaglandin D2 (PGD2 ) and cysteinyl leukotriene E4 (LTE4 ) are also increased in the airways of the same group of patients...
June 15, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29906692/rejection-sensitivity-and-psychopathology-symptoms-in-early-adolescence-the-moderating-role-of-personality-organization
#13
Andrea Fontana, Chiara De Panfilis, Erica Casini, Emanuele Preti, Juliette Richetin, Massimo Ammaniti
INTRODUCTION: Emerging personality organization may play an important role in the psychological adjustment of early adolescents, but research in this area is still limited. The current study evaluated if personality organization moderates the association between rejection sensitivity and adverse psychological outcomes in early adolescence. METHODS: Three-hundred eighty-six early adolescents (age range 13-15 years; 51% Female) attending junior high schools in Italy completed the semi-structured Interview of Personality Organization Processes in Adolescence (IPOP-A), the Children's Rejection Sensitivity Questionnaire (CRSQ), and the Youth Self Report/11-18 (YSR)...
June 12, 2018: Journal of Adolescence
https://www.readbyqxmd.com/read/29906606/the-evolutionary-history-of-lygodactylus-lizards-in-the-south-american-open-diagonal
#14
Flávia M Lanna, Fernanda P Werneck, Marcelo Gehara, Emanuel M Fonseca, Guarino R Colli, Jack W Sites, Miguel T Rodrigues, Adrian A Garda
The Pleistocenic Arc Hypothesis (PAH) posits that South American Seasonally Dry Tropical Forests (SDTF) were interconnected during Pleistocene glacial periods, enabling the expansion of species ranges that were subsequently fragmented in interglacial periods, promoting speciation. The lizard genus Lygodactylus occurs in Africa, Madagascar, and South America. Compared to the high diversity of African Lygodactylus, only two species are known to occur in South America, L. klugei and L. wetzeli, distributed in SDTFs and the Chaco, respectively...
June 12, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29905596/goal-importance-use-of-performance-measures-and-knowledge-exchange-an-empirical-study-on-general-practitioners-performance
#15
Antonella Cifalinò, Daniele Mascia, Emanuele Antonio Vendramini
BACKGROUND: In many health systems, general practitioners (GPs) exhibit high levels of isolation and, at the same time, low levels of organizational identification, which can hinder their individual performance. The extant health care literature suggests that the physicians' belief that organizational goals are important, the adoption of performance measurement systems, and knowledge-sharing practices affect their individual performance. Most research has investigated these constructs in isolation, however, rather than explored their collective impact on GPs' individual performance...
June 13, 2018: Health Care Management Review
https://www.readbyqxmd.com/read/29903633/incidence-and-reasons-of-pancreatic-resection-in-patients-with-asymptomatic-serous-cystadenoma
#16
Carlo Lombardo, Sara Iacopi, Francesca Menonna, Niccolò Napoli, Emanuele Kauffmann, Juri Bernardini, Andrea Cacciato Insilla, Piero Boraschi, Francescamaria Donati, Carla Cappelli, Daniela Campani, Davide Caramella, Ugo Boggi
BACKGROUND/OBJECTIVES: Despite diagnostic refinements, pancreatic resection (PR) is eventually performed in some patients with asymptomatic serous cystadenoma (A-SCA). The aim of this study was to define incidence and reasons of PR in A-SCA. METHODS: A retrospective analysis of a prospectively maintained database was performed for all the patients referred for pancreatic cystic lesions (PCL) between January 2005 and March 2016. RESULTS: Overall, there were 1488 patients with PCL, including 1271 (85...
June 8, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29902182/triticum-vulgare-extract-exerts-an-anti-inflammatory-action-in-two-in-vitro-models-of-inflammation-in-microglial-cells
#17
Luca Sanguigno, Antonella Casamassa, Niccola Funel, Massimiliano Minale, Rodolfo Riccio, Salvatore Riccio, Francesca Boscia, Paola Brancaccio, Luca Emanuele Pollina, Serenella Anzilotti, Gianfranco Di Renzo, Ornella Cuomo
Triticum vulgare has been extensively used in traditional medicine thanks to its properties of accelerating tissue repair. The specific extract of Triticum vulgare manufactured by Farmaceutici Damor (TVE-DAMOR) is already present in some pharmaceutical formulations used in the treatment of decubitus ulcers, skin lesions and burns. It has been recently suggested that this Triticum vulgare extract may possess potential anti-inflammatory properties. In the light of these premises the aim of the present paper was to verify the anti-inflammatory role of TVE, using the LPS-stimulated microglia model of inflammation...
2018: PloS One
https://www.readbyqxmd.com/read/29901810/on-x-mitral-valve-replacement-a-single-centre-experience-in-318-patients
#18
Giacomo Murana, Jacopo Alfonsi, Carlo Savini, Carlo Mariani, Giuditta Coppola, Valeria Lo Coco, Emanuele Pilato, Davide Pacini, Roberto Di Bartolomeo
OBJECTIVES: If mitral valve repair is not feasible, mitral valve replacement remains the only option. Based on our overall experience with the On-X mitral valve, the aim of this study was to investigate early and late outcomes after mitral valve replacement using this latest generation prosthesis. METHODS: From 1998 to 2016, 600 patients received an On-X prosthesis in the mitral position. Of them, we excluded all patients who had combined aortic procedures and retrospectively analysed 318 consecutive patients who had a mitral valve replacement...
June 12, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29900068/soft-bottom-fishes-and-spatial-protection-findings-from-a-temperate-marine-protected-area
#19
Inês Sousa, Jorge M S Gonçalves, Joachim Claudet, Rui Coelho, Emanuel J Gonçalves, Karim Erzini
Numerous studies over the last decades have focused on marine protected areas (MPAs) and their effects on fish communities. However, there is a knowledge gap regarding how species that live associated with soft-substrates (e.g., sand, mud) respond to spatial protection. We analyzed abundance, biomass and total lengths of the soft-bottom fishes in a multiple-use MPA in the north-eastern Atlantic, the Luiz Saldanha Marine Park (Portugal), during and after the implementation of its management plan. Data were collected by experimental fishing in areas with three different levels of protection, during the implementation period and for three years after full implementation of the MPA...
2018: PeerJ
https://www.readbyqxmd.com/read/29899753/non-coding-rnas-potentially-controlling-cell-cycle-in-the-model-caulobacter-crescentus-a-bioinformatic-approach
#20
Wanassa Beroual, Matteo Brilli, Emanuele G Biondi
Caulobacter crescentus represents a remarkable model system to investigate global regulatory programs in bacteria. In particular, several decades of intensive study have revealed that its cell cycle is controlled by a cascade of master regulators, such as DnaA, GcrA, CcrM, and CtrA, that are responsible for the activation of functions required to progress through DNA replication, cell division and morphogenesis of polar structures (flagellum and stalk). In order to accomplish this task, several post-translational (phosphorylation and proteolysis) and transcriptional mechanisms are involved...
2018: Frontiers in Genetics
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