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Generalized additive models

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https://www.readbyqxmd.com/read/27933415/association-between-gamma-glutamyltransferase-and-albuminuria-in-nondiabetic-adults-with-normal-renal-function
#1
Sun-Hye Ko, Myong Ki Baeg, Kyung-Do Han, Seung-Yeon Ko, Sae-Bom Shin, Seung-Hyun Ko, Yu-Bae Ahn
BACKGROUND: Serum gamma-glutamyltransferase (GGT) has been associated with albuminuria in diabetes patients, but it has not been investigated in the general population. We aimed to investigate the association between serum GGT and albuminuria in the nondiabetic Korean population with normal kidney function. METHODS: Study participants (3948; 1549 men and 2399 women) with an estimated glomerular filtration rate ≥60 mL/min/1.73 m(2) were analyzed from the fifth Korean National Health and Nutrition Examination Survey (2011)...
December 9, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27933021/dimensions-of-compulsive-exercise-across-eating-disorder-diagnostic-subtypes-and-the-validation-of-the-spanish-version-of-the-compulsive-exercise-test
#2
Sarah Sauchelli, Jon Arcelus, Roser Granero, Susana Jiménez-Murcia, Zaida Agüera, Amparo Del Pino-Gutiérrez, Fernando Fernández-Aranda
Objectives: Compulsive exercise in eating disorders has been traditionally considered as a behavior that serves the purpose of weight/shape control. More recently, it has been postulated that there may be other factors that drive the compulsive need to exercise. This has led to the development of the Compulsive Exercise Test (CET); a self-reported questionnaire that aims to explore the cognitive-behavioral underpinnings of compulsive exercise from a multi-faceted perspective. The objectives of this study were threefold: (1) to validate the Spanish version of the CET; (2) to compare eating disorder diagnostic subtypes and a healthy control group in terms of the factors that drive compulsive exercise as defined by the CET; (3) to explore how the dimensions evaluated in the CET are associated with eating disorder symptoms and general psychopathology...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27932962/neural-differences-between-covert-and-overt-attention-studied-using-eeg-with-simultaneous-remote-eye-tracking
#3
Louisa V Kulke, Janette Atkinson, Oliver Braddick
Research on neural mechanisms of attention has generally instructed subjects to direct attention covertly while maintaining a fixed gaze. This study combined simultaneous eye tracking and electroencephalogram (EEG) to measure neural attention responses during exogenous cueing in overt attention shifts (with saccadic eye movements to a target) and compared these with covert attention shifts (responding manually while maintaining central fixation). EEG analysis of the period preceding the saccade latency showed similar occipital response amplitudes for overt and covert shifts, although response latencies differed...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27932854/predictors-of-ageing-related-decline-across-multiple-cognitive-functions
#4
Stuart J Ritchie, Elliot M Tucker-Drob, Simon R Cox, Janie Corley, Dominika Dykiert, Paul Redmond, Alison Pattie, Adele M Taylor, Ruth Sibbett, John M Starr, Ian J Deary
It is critical to discover why some people's cognitive abilities age better than others'. We applied multivariate growth curve models to data from a narrow-age cohort measured on a multi-domain IQ measure at age 11 years and a comprehensive battery of thirteen measures of visuospatial, memory, crystallized, and processing speed abilities at ages 70, 73, and 76 years (n = 1091 at age 70). We found that 48% of the variance in change in performance on the thirteen cognitive measures was shared across all measures, an additional 26% was specific to the four ability domains, and 26% was test-specific...
November 2016: Intelligence
https://www.readbyqxmd.com/read/27930696/risk-factors-for-incidence-of-cardiovascular-diseases-and-all-cause-mortality-in-a-middle-eastern-population-over-a-decade-follow-up-tehran-lipid-and-glucose-study
#5
Mahsa Sardarinia, Samaneh Akbarpour, Mojtaba Lotfaliany, Farideh Bagherzadeh-Khiabani, Mohammadreza Bozorgmanesh, Farhad Sheikholeslami, Fereidoun Azizi, Farzad Hadaegh
BACKGROUND: To examine the association between potentially modifiable risk factors with cardiovascular disease (CVD) and all-cause mortality and to quantify their population attributable fractions (PAFs) among a sample of Tehran residents. METHODS: Overall, 8108 participants (3686 men) aged≥30 years, were investigated. To examine the association between risk factors and outcomes, multivariate sex-adjusted Cox proportional hazard regression analysis were conducted, using age as time-scale in two models including general/central adiposity: 1)adjusted for different independent variables including smoking, education, family history of CVD and sex for both outcomes and additionally adjusted for prevalent CVD for all-cause mortality 2)further adjusted for obesity mediators (hypertension, diabetes, lipid profile and chronic kidney disease)...
2016: PloS One
https://www.readbyqxmd.com/read/27930286/left-ventricular-geometry-and-risk-of-sudden-cardiac-arrest-in-patients-with-severely-reduced-ejection-fraction
#6
Derek Phan, Aapo L Aro, Kyndaron Reinier, Carmen Teodorescu, Audrey Uy-Evanado, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: Recent reports indicate that specific left ventricular (LV) geometric patterns predict recurrent ventricular arrhythmias in patients with implantable cardioverter-defibrillators and reduced left ventricular ejection fraction (LVEF). However, this relationship has not been evaluated among patients at risk of sudden cardiac arrest (SCA) in the general population. METHODS AND RESULTS: Adult SCA cases from the Oregon Sudden Unexpected Death Study were compared with geographic controls with no prior history of SCA...
August 18, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27929508/development-of-a-universal-medical-x-ray-imaging-phantom-prototype
#7
Annemari Groenewald, Willem A Groenewald
Diagnostic X-ray imaging depends on the maintenance of image quality that allows for proper diagnosis of medical conditions. Maintenance of image quality requires quality assurance programs on the various X-ray modalities, which consist of pro-jection radiography (including mobile X-ray units), fluoroscopy, mammography, and computed tomography (CT) scanning. Currently a variety of modality-specific phantoms are used to perform quality assurance (QA) tests. These phantoms are not only expensive, but suitably trained personnel are needed to successfully use them and interpret the results...
November 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27929333/expressive-writing-among-chinese-american-breast-cancer-survivors-a-randomized-controlled-trial
#8
Qian Lu, Celia Ching Yee Wong, Matthew W Gallagher, Reese Y W Tou, Lucy Young, Alice Loh
OBJECTIVE: Despite the significant size of the Asian American population, few studies have been conducted to improve cancer survivorship in this underserved group. Research has demonstrated that expressive writing interventions confer physical and psychological benefits for a variety of populations, including Non-Hispanic White cancer survivors. The study aims to evaluate the health benefits of an expressive writing intervention among Chinese-speaking breast cancer survivors in the U...
December 8, 2016: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/27929151/principal-molecular-axis-and-transition-dipole-moment-orientations-in-liquid-crystal-systems-an-assessment-based-on-studies-of-guest-anthraquinone-dyes-in-a-nematic-host
#9
Mark T Sims, Laurence C Abbott, Stephen J Cowling, John W Goodby, John N Moore
An assessment of five different definitions of the principal molecular axis along which molecules align in a nematic liquid crystal system has been made by analysing fully atomistic molecular dynamics (MD) simulations of a set of anthraquinone dyes in the cyanobiphenyl-based nematic host mixture E7. Principal molecular axes of the dyes defined by minimum moment of inertia, minimum circumference, minimum area, maximum aspect ratio, and surface tensor models were tested, and the surface tensor model was found to give the best description...
December 8, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27927845/embryo-donation-and-understanding-of-kinship-the-impact-of-law-and-policy
#10
Jenni Millbank, Anita Stuhmcke, Isabel Karpin
STUDY QUESTION: What is the impact of law and policy upon the experience of embryo donation for reproductive use? SUMMARY ANSWER: Access to, and experience of, embryo donation are influenced by a number of external factors including laws that impose embryo storage limits, those that frame counselling and approval requirements and allow for, or mandate, donor identity disclosure. WHAT IS KNOWN ALREADY: To date only three qualitative studies in Australia and New Zealand have been completed on the experience of embryo donation for reproductive purposes, each with a small cohort of interviewees and divergent findings...
December 6, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27927842/parental-contributions-to-early-embryo-development-influences-of-urinary-phthalate-and-phthalate-alternatives-among-couples-undergoing-ivf-treatment
#11
Haotian Wu, Lisa Ashcraft, Brian W Whitcomb, Tayyab Rahil, Ellen Tougias, Cynthia K Sites, J Richard Pilsner
STUDY QUESTION: Are preconception urinary concentrations of phthalates and phthalate alternatives associated with diminished early stage embryo quality in couples undergoing IVF? SUMMARY ANSWER: Male, but not female, urinary concentrations of select metabolites of phthalates and phthalate alternatives are associated with diminished blastocyst quality. WHAT IS KNOWN ALREADY: Although phthalates are endocrine disrupting compounds associated with adverse reproductive health, they are in widespread use across the world...
December 7, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27927606/the-association-between-internet-use-and-ambulatory-care-seeking-behaviors-in-taiwan-a-cross-sectional-study
#12
Ronan Wenhan Hsieh, Likwang Chen, Tsung-Fu Chen, Jyh-Chong Liang, Tzu-Bin Lin, Yen-Yuan Chen, Chin-Chung Tsai
BACKGROUND: Compared with the traditional ways of gaining health-related information from newspapers, magazines, radio, and television, the Internet is inexpensive, accessible, and conveys diverse opinions. Several studies on how increasing Internet use affected outpatient clinic visits were inconclusive. OBJECTIVE: The objective of this study was to examine the role of Internet use on ambulatory care-seeking behaviors as indicated by the number of outpatient clinic visits after adjusting for confounding variables...
December 7, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27926759/mortality-and-prehospital-blood-pressure-in-patients-with-major-traumatic-brain-injury-implications-for-the-hypotension-threshold
#13
Daniel W Spaite, Chengcheng Hu, Bentley J Bobrow, Vatsal Chikani, Duane Sherrill, Bruce Barnhart, Joshua B Gaither, Kurt R Denninghoff, Chad Viscusi, Terry Mullins, P David Adelson
Importance: Current prehospital traumatic brain injury guidelines use a systolic blood pressure threshold of less than 90 mm Hg for treating hypotension for individuals 10 years and older based on studies showing higher mortality when blood pressure drops below this level. However, the guidelines also acknowledge the weakness of the supporting evidence. Objective: To evaluate whether any statistically supportable threshold between systolic pressure and mortality emerges from the data a priori, without assuming that a cut point exists...
December 7, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27926743/antecedents-of-new-onset-major-depressive-disorder-in-children-and-adolescents-at-high-familial-risk
#14
Frances Rice, Ruth Sellers, Gemma Hammerton, Olga Eyre, Rhys Bevan-Jones, Ajay K Thapar, Stephan Collishaw, Gordon T Harold, Anita Thapar
Importance: Early-onset major depressive disorder (MDD) is common in individuals at high familial risk of depression and is associated with poor long-term mental health, social, and educational outcomes. Objectives: To examine the developmental pathways that lead to first-episode adolescent-onset MDD (incident cases) in those at high familial risk and to postulate a theoretically informed model that enables simultaneous testing of different pathways to incident adolescent-onset MDD composed of contributions from familial/genetic and social risk factors, as well as effects via specific clinical antecedents...
December 7, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27925764/framework-for-assessment-of-children-s-social-competence-with-particular-focus-on-children-with-brain-injuries
#15
Rebecca Ashton
Children's social competence is important for their general wellbeing and life satisfaction. Often it is an area identified as problematic for children brought to the attention of a psychologist, particularly for children with brain injuries. However, it can be difficult to pin down exactly where social difficulties lie, and therefore how best to help. The current article draws together the literature on social competence from brain injury and from more general developmental research. A hierarchical model is presented with three layers: social adjustment, social functioning, and social cognition...
December 7, 2016: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/27924717/effects-of-benzo-a-pyrene-aromatic-amines-and-a-combination-of-both-on-cyp1a1-activities-in-rt-4-human-bladder-papilloma-cells
#16
Sabine Plöttner, Lilian Annika Bastian, Heiko Udo Käfferlein, Thomas Brüning
The interaction of arylamines and polycyclic aromatic hydrocarbons (PAH) is of particular interest in the etiology of bladder cancer. The aim of this study was to (1) examine the metabolic capacity of RT-4 human bladder papilloma cells and (2) investigate the influence of aromatic amines on the induction of cytochrome P-450 1A1 (CYP1A1) activity and their effects on benzo[a]pyrene (BaP)-induced CYP1A1 activities. Cells were incubated for 24 h with different concentrations of BaP, 1- or 2-naphthylamine (NA), 2-, 3-, or 4-aminobiphenyl (ABP), and binary mixtures consisting of 1 µM BaP and different concentrations of each arylamine...
2016: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/27924525/a-three-day-consecutive-fingolimod-administration-improves-neurological-functions-and-modulates-multiple-immune-responses-of-cci-mice
#17
Chuang Gao, Yu Qian, Jinhao Huang, Dong Wang, Wanqiang Su, Peng Wang, Linyue Guo, Wei Quan, Shuo An, Jianning Zhang, Rongcai Jiang
Excessive inflammation after traumatic brain injury (TBI) is a major cause of secondary TBI. Though several inflammatory biomarkers have been postulated as the risk factors of TBI, there has not been any comprehensive description of them. Fingolimod, a new kind of immunomodulatory agent which can diminish various kinds of inflammatory responses, has shown additional therapeutic effects in the treatment of intracranial cerebral hematoma (ICH), ischemia, spinal cord injury (SCI), and many other CNS disorders...
December 6, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27924515/effect-of-kruppel-like-factor-4-on-notch-pathway-in-hepatic-stellate-cells
#18
Yin-Kai Xue, Jun Tan, Dong-Wei Dou, Ding Chen, Lu-Jia Chen, Huan-Ping Ren, Li-Bo Chen, Xin-Gao Xiong, Hai Zheng
The relationship between Kruppel-like factor 4 (KLF4) and the Notch pathway was determined to investigate the effect of KLF4 on the activation of hepatic stellate cells and underlying mechanisms. Fifty SPF BALB/c mice were randomly divided into two groups. A liver fibrosis model was established in 25 mice as the experimental group, and the remaining 25 mice served as controls. On the day 0, 7, 14, and 35, liver tissues were removed for immunofluorescent detection. The Notch pathway inhibitor DAPT was added to the primary original hepatic stellate cells, and KLF4 and Notch-associated factor expression was detected by qRT-PCR...
December 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27924453/functional-dedifferentiation-and-reduced-task-related-deactivations-underlie-the-age-related-decline-of-prospective-memory
#19
Julie Gonneaud, Grégory Lecouvey, Mathilde Groussard, Malo Gaubert, Brigitte Landeau, Florence Mézenge, Vincent de La Sayette, Francis Eustache, Béatrice Desgranges, Géraldine Rauchs
Prospective memory (PM) refers to the ability to remember to execute an intention at the appropriate moment in the future, which can be performed either at the appearance of an event (event-based, EBPM) or after a certain amount of time (time-based, TBPM). PM is generally impaired during aging but the cerebral substrates of this decline have been little investigated. Using functional Magnetic Resonance Imaging (fMRI), we investigated the neural bases of PM in 20 young and 20 healthy older adults. They were proposed a task of semantic categorisation of pictures (ongoing task)...
December 6, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27923874/inmate-violence-and-correctional-staff-burnout-the-role-of-sense-of-security-gender-and-job-characteristics
#20
Anna Isenhardt, Ueli Hostettler
Violence in the workplace has serious consequences for employees and organizations. Based on a survey in early 2012 among employees from all work areas of 89 of the total 112 correctional facilities in Switzerland resulting in a sample of 2,045 employees (response rate 48.5%), this study (a) analyzed whether victimization has an impact on correctional staff burnout, (b) tested the hypothetical mediating role of sense of security in the relationship between victimization and burnout, and (c) included gender and job characteristics because work experiences and exposure to violence of staff differ strongly with gender and work tasks...
December 5, 2016: Journal of Interpersonal Violence
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