Yizheng Liang, Lorraine O'Driscoll, Susan McDonnell, Padraig Doolan, Irene Oglesby, Kieran Duffy, Robert O'Connor, Martin Clynes
The human lung carcinoma cell line DLKP was exposed to sequential pulses of 10 commonly used chemotherapeutic drugs (VP-16, vincristine, taxotere, mitoxantrone, 5-fluorouracil, methotrexate, CCNU, BCNU, cisplatin and chlorambucil); resulting cell lines exhibited resistance to the selecting agents (ranging approx. 1.5- to 36-fold) and, in some cases, cross-resistance to methotrexate (approx. 1.4- to 22-fold), vincristine (1.6- to 262-fold), doxorubicin (Adriamycin, approx. 1.1- to 33-fold) and taxotere (approx...
September 10, 2004: International Journal of Cancer. Journal International du Cancer