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NAD+ AND NQO1

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https://www.readbyqxmd.com/read/29659176/nrf2-attenuates-inflammatory-response-in-copd-emphysema-crosstalk-with-wnt3a-%C3%AE-catenin-and-ampk-pathways
#1
Wenhui Cui, Zhihui Zhang, Panpan Zhang, Jiao Qu, Cheng Zheng, Xiaoting Mo, Wencheng Zhou, Liang Xu, Hongwei Yao, Jian Gao
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and abnormal inflammatory response. Wnt/β-catenin and AMP-activated protein kinase (AMPK) have been shown to modulate lung inflammatory responses and injury. However, it remains elusive whether Wnt/β-catenin and AMPK modulate nuclear factor erythroid-2 related factor-2 (Nrf2)-mediated protective responses during the development of emphysema. Here we showed that treatment with a Wnt pathway activator (LiCl) reduced elastase-induced airspace enlargement and cigarette smoke extract (CSE)-induced lung inflammatory responses in WT mice, which was associated with increased activation of Nrf2 pathway...
April 16, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29652514/-nqo1-gene-c609t-polymorphism-dbsnp-rs1800566-and-digestive-tract-cancer-risk-a-meta-analysis
#2
Upendra Yadav, Pradeep Kumar, Vandana Rai
Several studies reported that polymorphism C609T (rs1800566) in (NAD(P)H): quinoneoxidoreductase 1 (NQO1) gene is associated with risk to digestive tract (DT) cancers, like esophageal cancer (EC), gastric cancer (GC), and colorectal cancer (CRC). Authors conducted a meta-analysis to investigate association between C609T polymorphism and DT cancer risk. Eligible studies were extracted from the databases of PubMed, Google Scholar, Science Direct, and Springer Link. All retrieved articles were evaluated. All statistical analyses were performed using Open Meta-Analyst and MIX1...
April 13, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29642608/neuroprotective-effects-of-four-phenylethanoid-glycosides-on-h%C3%A2-o%C3%A2-induced-apoptosis-on-pc12-cells-via-the-nrf2-are-pathway
#3
Maiquan Li, Tao Xu, Fei Zhou, Mengmeng Wang, Huaxin Song, Xing Xiao, Baiyi Lu
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor against oxidative stress and neurodegenerative disorders. Phenylethanoid glycosides (PhGs; salidroside, acteoside, isoacteoside, and echinacoside) exhibit antioxidant and neuroprotective bioactivities. This study was performed to investigate the neuroprotective effect and molecular mechanism of PhGs. PhGs pretreatment significantly suppressed H₂O₂-induced cytotoxicity in PC12 cells by triggering the nuclear translocation of Nrf2 and reversing the downregulated protein expression of heme oxygenase 1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), glutamate cysteine ligase-catalytic subunit (GCLC), and glutamate-cysteine ligase modifier subunit (GCLM)...
April 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29626606/curcumin-provides-neuroprotection-in-models-of-traumatic-brain-injury-via-the-nrf2-are-signaling-pathway
#4
Wei Dai, Handong Wang, Jiang Fang, Yihao Zhu, Jian Zhou, Xiaoliang Wang, Yuan Zhou, Mengliang Zhou
Curcumin has been found to play the protective role in many neurological disorders, however, its roles and the underlying molecular mechanisms in traumatic brain injury (TBI) are not fully understood. The aim of this study was to investigate the potential neuroprotection of curcumin and the possible role of Nrf2-ARE pathway in the weight-drop model of TBI. The administration of curcumin significantly ameliorated secondary brain injury induced by TBI, such as brain water content, oxidative stress, neurological severity score, and neuronal apoptosis...
April 4, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29621903/impact-of-nrf2-on-tumor-growth-and-drug-sensitivity-in-oncogenic-k-ras-transformed-cells-in-vitro-and-in-vivo
#5
Jiajia Shao, Christophe Glorieux, Jianwei Liao, Ping Chen, Wenhua Lu, Zhenhao Liang, Shijun Wen, Yumin Hu, Peng Huang
K-ras is one of the most common oncogenes in human cancers, and its aberrant activation may lead to malignant transformation associated with oxidative stress and activation of the transcription factor Nrf2 that regulates multiple detoxification enzymes. The purpose of this research was to use gene editing technology to evaluate the role of Nrf2 in affecting tumor growth and drug sensitivity of K-rasG12V -transformed cells. We showed that induction of K-rasG12V caused a significant activation of Nrf2 associated with increased expression of its target genes NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1)...
April 5, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29621130/astaxanthin-promotes-nrf2-are-signaling-to-inhibit-hg-induced-renal-fibrosis-in-gmcs
#6
Xi Xie, Qing Chen, Jun Tao
Oxidative stress is the main cause of diabetic nephropathy (DN) progression. Nuclear factor-erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling is a crucial cellular defense system to cope with oxidative stress. Astaxanthin (AST) is a fat-soluble xanthophyll carotenoid with remarkable antioxidative capacity. AST exerted renal protective in diabetic rats. This study aimed to determine whether AST could alleviate the pathological progress of DN by activating Nrf2/ARE signaling and diminishing the excessive oxidative stress and fibronectin (FN) accumulation in glomerular mesangial cells (GMCs) challenged with high glucose (HG)...
April 5, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29615906/mechanisms-of-triptolide-induced-hepatotoxicity-and-protective-effect-of-combined-use-of-isoliquiritigenin-possible-roles-of-nrf2-and-hepatic-transporters
#7
Zhenyan Hou, Lei Chen, Pingfei Fang, Hualin Cai, Huaibo Tang, Yongbo Peng, Yang Deng, Lingjuan Cao, Huande Li, Bikui Zhang, Miao Yan
Triptolide (TP), the main bioactive component of Tripterygium wilfordii Hook F, can cause severe hepatotoxicity. Isoliquiritigenin (ISL) has been reported to be able to protect against TP-induced liver injury, but the mechanisms are not fully elucidated. This study aims to explore the role of nuclear transcription factor E2-related factor 2 (Nrf2) and hepatic transporters in TP-induced hepatotoxicity and the reversal protective effect of ISL. TP treatment caused both cytotoxicity in L02 hepatocytes and acute liver injury in mice...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29571471/persimmon-vinegar-polyphenols-protect-against-hydrogen-peroxide-induced-cellular-oxidative-stress-via-nrf2-signalling-pathway
#8
Bo Zou, Gengsheng Xiao, Yujuan Xu, Jijun Wu, Yuanshan Yu, Manqin Fu
Since polyphenols are known to exhibit antioxidative properties, we prepared and characterized persimmon vinegar polyphenols (PVP) in this study. Furthermore, we investigated the protective effect of PVP on hydrogen peroxide (H2 O2 )-induced oxidative stress in HepG2 cells and its underlying mechanisms. Our results showed that flavon-3-ols were the predominant polyphenols in PVP. Pre-treatment with PVP significantly decreased (p < 0.05) H2 O2 -induced cell damage in a dose-dependent manner, accompanied by decrease in lactate dehydrogenase (LDH) leakage, aminotransferase activities, and ROS accumulation...
July 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29570846/neuroprotective-effects-of-creatine-in-the-cmvmjd135-mouse-model-of-spinocerebellar-ataxia-type-3
#9
Sara Duarte-Silva, Andreia Neves-Carvalho, Carina Soares-Cunha, Joana M Silva, Andreia Teixeira-Castro, Rita Vieira, Anabela Silva-Fernandes, Patrícia Maciel
BACKGROUND AND OBJECTIVE: Mitochondrial dysfunction has been implicated in several neurodegenerative diseases. Creatine administration increases concentration of the energy buffer phosphocreatine, exerting protective effects in the brain. We evaluate whether a creatine-enriched diet would be beneficial for a mouse model of spinocerebellar ataxia type 3, a genetically defined neurodegenerative disease for which no treatment is available. METHODS: We performed 2 independent preclinical trials using the CMVMJD135 mouse model (treating 2 groups of animals with different disease severity) and wild-type mice, to which 2% creatine was provided for 19 (preclinical trial 1) or 29 (preclinical trial 2) weeks, starting at a presymptomatic age...
March 23, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29568961/cytoprotective-effects-of-diosmetin-against-hydrogen-peroxide-induced-l02-cell-oxidative-damage-via-activation-of-the-nrf2-are-signaling-pathway
#10
Chunjing Wang, Yaping Liao, Shengnan Wang, Dan Wang, Nana Wu, Qingao Xu, Wanwan Jiang, Menran Qiu, Changqing Liu
Oxidative stress is considered a crucial mediator in the pathogenesis of various liver diseases. The flavone diosmetin has been reported to exhibit antioxidant activities; however, the hepatoprotective effects of diosmetin against oxidative stress, and the underlying molecular mechanisms, remain unknown. The present study aimed to investigate the potential hepatoprotective effects of diosmetin on hydrogen peroxide (H2O2)‑induced oxidative damage in L02 cells and attempted to evaluate the role of the nuclear factor erythroid 2‑related factor 2 (Nrf2)/antioxidant response element pathway in this process...
March 15, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29552149/nf-e2-related-factor-2-serves-a-key-function-in-resistance-to-malignant-transformation-of-beas-2b-cells-induced-by-coal-tar-pitch
#11
Songcheng Yu, Zhen Yan, Feifei Feng, Jing Ni, Wei Wang, Kadijatu Nabie, Yiguo Zhang, Lingbo Qu, Yongjun Wu
Coal tar pitch (CTP) is a key factor in the development of occupational lung cancer. In order to investigate the function of the anti-oxidative signaling pathway regulated by NF-E2-related factor 2 (Nrf2) during cancer development, BEAS-2B cells were cultured with CTP extract for 30 passages. It was revealed that malignant transformation occurred in cells between the 20 and 30th passage. The expression levels of Nrf2 and NAD(P)H:quinone oxidoreductase 1 (NQO1) were promoted throughout the CTP exposure culture, and there was a positive linear correlation between the expression levels of Nrf2 and NQO1...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29494960/prevention-of-doxorubicin-dox-induced-genotoxicity-and-cardiotoxicity-effect-of-plant-derived-small-molecule-indole-3-carbinol-i3c-on-oxidative-stress-and-inflammation
#12
Subhadip Hajra, Arup Ranjan Patra, Abhishek Basu, Sudin Bhattacharya
Doxorubicin (DOX) is an anthracycline group of antibiotic available for the treatment of broad spectrum of human cancers. However, patient receiving DOX-therapy, myelosuppression and genotoxicity which may lead to secondary malignancy and dose dependent cardiotoxicity is an imperative adverse effect. Mechanisms behind the DOX-induced toxicities are increased level of oxidative damage, inflammation and apoptosis. Therefore, in search of a potential chemoprotectant, naturally occurring glucosinolate breakdown product Indole-3-Carbinol (I3C) was evaluated against DOX-induced toxicities in Swiss albino mice...
February 26, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29458270/the-involvement-of-nrf2-antioxidant-signaling-pathway-in-the-protection-of-monocrotaline-induced-hepatic-sinusoidal-obstruction-syndrome-in-rats-by-catechin-hydrate
#13
Xiaoqi Jing, Jiaqi Zhang, Zhenlin Huang, Yuchen Sheng, Lili Ji
Hepatic sinusoidal obstruction syndrome (HSOS) is a rare and life-threatening liver disease. (+)-catechin is a natural dietary flavonol with high antioxidant capacity. This study aims to investigate the involvement of nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant signaling pathway in the protection of (+)-catechin hydrate (CAT) against monocrotaline (MCT)-induced HSOS. Results of serum alanine/aspartate aminotransferases (ALT/AST) activities, total bilirubin (TBil) and bile acids (TBA) amounts, liver histological observation, scanning electron microscope evaluation and hepatic metalloproteinase-9 (MMP-9) expression all demonstrated the protection of CAT against MCT-induced HSOS in rats...
February 20, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29453911/induction-of-xenobiotic-metabolizing-enzymes-in-hepatocytes-by-beta-naphthoflavone-time-dependent-changes-in-activities-protein-and-mrna-levels
#14
Kateřina Lněničková, Lenka Skálová, Lucie Stuchlíková, Barbora Szotáková, Petra Matoušková
In the present study, time-dependency of the induction effect of a selective inducer on the activity, protein and mRNA levels of cytochromes P450 1A1/2 (CYP1A1/2), NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione S-transferases (GSTA), in primary culture of rat hepatocytes was tested and evaluated. To show the differences in responses of tested enzymes, the common aryl hydrocarbon receptor (AhR) ligand agonist, beta-naphthoflavone (BNF), was used. Induction of CYP1A1/2 by BNF was detected at all time intervals and at all levels (i...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29434949/carnosic-acid-an-inducer-of-nad-p-h-quinone-oxidoreductase-1-enhances-the-cytotoxicity-of-%C3%AE-lapachone-in-melanoma-cell-lines
#15
Nobuyuki Arakawa, Ayaka Okubo, Shinji Yasuhira, Kazuhiro Takahashi, Hiroo Amano, Toshihide Akasaka, Tomoyuki Masuda, Masahiko Shibazaki, Chihaya Maesawa
NAD(P)H quinone oxidoreductase 1 (NQO1)-dependent antitumor drugs such as β-lapachone (β-lap) are attractive candidates for cancer chemotherapy because several tumors exhibit higher expression of NQO1 than adjacent tissues. Although the association between NQO1 and β-lap has been elucidated, the effects of a NQO1-inducer and β-lap used in combination remain to be clarified. It has previously been reported that melanoma cell lines have detectable levels of NQO1 expression and are sensitive to NQO1-dependent drugs such as 17-allylamino-17-demethoxygeldanamycin...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433360/ampk-nrf2-signaling-is-involved-in-the-anti-neuroinflammatory-action-of-petatewalide-b-from-petasites-japonicus-against-lipopolysaccharides-in-microglia
#16
Sun Young Park, Min Hyun Choi, Mei Li, Ke Li, Geuntae Park, Young-Whan Choi
OBJECTIVES: Abnormal microglia secrete neuroinflammatory factors that play a pivotal role in neurodegenerative-disorder development. Thus, regulating abnormal microglia-activation could be a promising therapeutic strategy. The purposes of this study included investigating the effect of Petatewalide B on lipopolysaccharide- (LPS-) stimulated microglia and exploring the role of the AMPK/Nrf2- (adenosine monophosphate-activated protein kinase/nuclear factor erythroid 2-related factor 2) signaling pathway in the anti-neuroinflammatory function of Petatewalide B...
February 12, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29414880/hematological-abnormality-oxidative-stress-and-genotoxicity-induction-in-the-greenhouse-pesticide-sprayers-investigating-the-role-of-nqo1-gene-polymorphism
#17
Nahid Ahmadi, Ali Mandegary, Akram Jamshidzadeh, Mohaddeseh Mohammadi-Sardoo, Mohammadreza Mohammadi-Sardo, Elham Salari, Leyla Pourgholi
The widespread use of pesticides in agriculture represents a threat to the human populations exposed to them. In this cross-sectional study, the hematological and biochemical parameters, plasma cholinesterase (PChE) activity, oxidative stress, genotoxicity, and NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism were measured in 100 greenhouse workers occupationally exposed to pesticide mixture and 104 normal healthy controls. There was a decrease in erythrocytes (5.45%, p = 0.026) and hemoglobin (3...
February 7, 2018: Toxics
https://www.readbyqxmd.com/read/29402993/partial-involvement-of-nrf2-in-skeletal-muscle-mitohormesis-as-an-adaptive-response-to-mitochondrial-uncoupling
#18
Verena Coleman, Piangkwan Sa-Nguanmoo, Jeannette Koenig, Tim J Schulz, Tilman Grune, Susanne Klaus, Anna P Kipp, Mario Ost
Mitochondrial dysfunction is usually associated with various metabolic disorders and ageing. However, salutary effects in response to mild mitochondrial perturbations have been reported in multiple organisms, whereas molecular regulators of cell-autonomous stress responses remain elusive. We addressed this question by asking whether the nuclear factor erythroid-derived-like 2 (Nrf2), a transcription factor and master regulator of cellular redox status is involved in adaptive physiological responses including muscle mitohormesis...
February 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29400110/scutellarin-ameliorates-nonalcoholic-fatty-liver-disease-through-the-ppar%C3%AE-pgc-1%C3%AE-nrf2-pathway
#19
Xiaoxue Zhang, Renpeng Ji, Huijun Sun, Jinyong Peng, Xiaodong Ma, ChangYuan Wang, Yufeng Fu, Liuchi Bao, Yue Jin
Nonalcoholic fatty liver disease (NAFLD) is characterised by excessive accumulation of hepatic lipids and oxidative injury of hepatocytes. Scutellarin is a flavonoid glycoside having antioxidative stress activity. Our current study aims to investigate the molecular mechanism of scutellarin ameliorating NAFLD. Scutellarin treatment was applied to male C57BL/6 mice maintained on a high-fat diet (HFD) and HepG2 cells challenged with oleic acid. The antioxidation biochemical indicators and lipid levels in the liver and cells were detected by kits...
February 5, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29394555/-a-case-of-ascending-colon-cancer-with-synchronous-liver-metastases-and-peritoneal-dissemination
#20
Masato Mito, Hitoshi Kameyama, Yoshifumi Shimada, Saki Yamada, Shinnosuke Hotta, Yuki Hirose, Ryoma Yagi, Yosuke Tajima, Mae Nakano, Takuma Okamura, Masato Nakano, Hiroshi Ichikawa, Masayuki Nagahashi, Jun Sakata, Toshifumi Wakai
The patient was a 73-year-old man with ascending colon cancer and synchronous liver metastases. A right hemicolectomy with a lymph node dissection was performed for the primary lesion. The resected specimen revealed a KRAS codon 12 mutation. After 6 courses of chemotherapy with capecitabine, oxaliplatin, and bevacizumab(Bv), we performed a partial hepatectomy and resection of the peritoneal dissemination. A computed tomography(CT)scan 5 months later revealed the recurrence of the liver metastases. After 8 courses of chemotherapy with 5-fluorouracil, Leucovorin, irinotecan, and Bv, we performed a partial hepatectomy...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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