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Zinc toxicity

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https://www.readbyqxmd.com/read/28629056/antimicrobial-and-antioxidant-potentials-of-biosynthesized-colloidal-zinc-oxide-nanoparticles-for-a-fortified-cold-cream-formulation-a-potent-nanocosmeceutical-application
#1
Sonia S, Linda Jeeva Kumari H, Ruckmani K, Sivakumar M
Nanocosmeceuticals are promising applications of nanotechnology in personal care industries. Zinc oxide is an inorganic material that is non-toxic and skin compatible with self-cleansing and microbicidal properties. Herein, exploitation of colloidal zinc oxide nanoparticles (ZnONps) as potent biomaterial for a topical formulation of cosmetic and dermatological significance is employed. ZnONps were green synthesized using environmentally benign Adhatoda vasica leaf extract and characterized by UV-Vis absorption spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), dynamic light scattering (DLS), high-resolution transmission electron microscopy (HR-TEM) and energy-dispersive X-ray spectroscopy (EDX)...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28627288/biocompatibility-of-filomicelles-prepared-from-poly-ethylene-glycol-polylactide-diblock-copolymers-as-potential-drug-carrier
#2
Xin Shen, Xue Liu, Rongye Li, Peng Yun, Chenglong Li, Feng Su, Suming Li
A series of poly(ethylene glycol)-polylactide (PEG-PLA) diblock copolymers were synthesized by ring-opening polymerization of L-lactide using monomethoxy PEG as macroinitiator and zinc lactate as catalyst. Filomicelles were prepared from the resulting copolymers by co-solvent evaporation method. The biocompatibility of the various filomicelles was evaluated with the aim of assessing their potential as drug carriers. Various aspects of biocompatibility were considered, including agar diffusion test, MTT assay, release of cytokines, hemolytic test, dynamic clotting time, protein adsorption in vitro, and zebrafish embryonic compatibility in vivo...
June 17, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28624948/metal-release-from-contaminated-leaf-litter-and-leachate-toxicity-for-the-freshwater-crustacean-gammarus-fossarum
#3
Florence Maunoury-Danger, Vincent Felten, Clément Bojic, Fabrice Fraysse, Mar Cosin Ponce, Odile Dedourge-Geffard, Alain Geffard, François Guérold, Michael Danger
Industrialization has left large surfaces of contaminated soils, which may act as a source of pollution for contiguous ecosystems, either terrestrial or aquatic. When polluted sites are recolonized by plants, dispersion of leaf litter might represent a non-negligible source of contaminants, especially metals. To evaluate the risks associated to contaminated leaf litter dispersion in aquatic ecosystems, we first measured the dynamics of metal loss from leaf litter during a 48-h experimental leaching. We used aspen (Populus tremula L...
June 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28623275/influences-of-temperature-and-salinity-on-physicochemical-properties-and-toxicity-of-zinc-oxide-nanoparticles-to-the-marine-diatom-thalassiosira-pseudonana
#4
Mana M N Yung, Kevin W H Kwok, Aleksandra B Djurišić, John P Giesy, Kenneth M Y Leung
Climate change is predicted to result in rising average temperature of seawater with more extreme thermal events, and frequent rainfalls in some coastal regions. It is imperative to understand how naturally mediated changes in temperature and salinity can modulate toxicity of chemical contaminants to marine life. Thus, this study investigated combined effects of temperature and salinity on toxicity of zinc oxide nanoparticles (ZnO-NPs) to the marine diatom Thalassiosira pseudonana. Because ZnO-NPs formed larger aggregations and released less zinc ions (Zn(2+)) at greater temperature and salinity, toxicity of ZnO-NPs to T...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28617866/characterization-of-trace-metal-content-in-the-developing-zebrafish-embryo
#5
Rebecca T Thomason, Michael A Pettiglio, Carolina Herrera, Clara Kao, Jonathan D Gitlin, Thomas B Bartnikas
Trace metals are essential for health but toxic when present in excess. The maintenance of trace metals at physiologic levels reflects both import and export by cells and absorption and excretion by organs. The mechanism by which this maintenance is achieved in vertebrate organisms is incompletely understood. To explore this, we chose zebrafish as our model organism, as they are amenable to both pharmacologic and genetic manipulation and comprise an ideal system for genetic screens and toxicological studies...
2017: PloS One
https://www.readbyqxmd.com/read/28617267/removal-of-cadmium-and-zinc-from-contaminated-wastewater-using-rhodobacter-sphaeroides
#6
Xiaomin Li, Weihua Peng, Yingying Jia, Lin Lu, Wenhong Fan
Rhodobacter sphaeroides was used for bioremediation of wastewater polluted with cadmium (Cd) and zinc (Zn). The tolerance of the microorganism to selected heavy metals (HMs), as well as the effects of pH, temperature and inoculum size on the removal rate, was investigated. The remediation effects of R. sphaeroides were analysed at different initial concentrations of HMs. Bioremediation mechanisms were thoroughly discussed based on the results from the cell characterisation analysis. Cd and Zn could inhibit the growth of R...
June 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28605861/sensitivity-of-the-glochidia-larvae-of-freshwater-mussels-bivalvia-unionida-hyriidae-to-cadmium-cobalt-copper-lead-nickel-and-zinc-differences-between-metals-species-and-exposure-time
#7
Scott J Markich
Freshwater mussels (Bivalvia: Unionida) are among the most threatened freshwater faunal groups worldwide. Metal contamination is one threat that has been linked to declining mussel population distribution and abundance. This study determined the sensitivity (valve closure) of the glochidia (larvae) of six species of Australian freshwater mussels to cadmium (Cd), cobalt (Co), copper (Cu), lead (Pb), nickel (Ni) and zinc (Zn), key metal contaminants impacting urbanized coastal rivers in south-eastern Australia (home to ~50% of the population), in a soft reconstituted freshwater (hardness 42mgCaCO3L(-1); alkalinity 22mgCaCO3L(-1) and pH7...
June 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28597086/influence-of-a-former-mining-area-in-the-heavy-metals-concentrations-in-blood-of-free-living-mediterranean-pond-turtles-mauremys-leprosa
#8
E Martínez-López, P Gómez-Ramírez, S Espín, M P Aldeguer, A J García-Fernández
The objective of this study was to assess metal exposure in the Mediterranean Pond Turtle (Mauremys leprosa) inhabiting a watercourse in an ancient mining district polluted by different metals ("Rambla de Las Moreras", southeastern Spain) and included in the Ramsar Convention. For this purpose, mercury (Hg), lead (Pb), copper (Cu), zinc (Zn) and cadmium (Cd) were analysed in blood samples from 42 M. leprosa healthy adults (27 males and 13 females). The highest median concentrations were found for Zn, followed by Cu, Pb, Hg and Cd (366, 33, 9, 0...
June 9, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28595798/mineral-content-of-smooth-scallop-flexopecten-glaber-caught-canakkale-turkey-and-evaluation-in-terms-of-food-safety
#9
Nermin Berik, Ekrem Cem Çankırılıgil, Güzin Gül
In this research, one of the most promising scallop species, smooth scallop (Flexopecten glaber) was studied. According to our findings, smooth scallop has beneficial micro and macro minerals, fat and carbohydrate just before the spawning. While the ratios protein, ash and water decreased from autumn to summer, ratio of crude fat increased till reproduction season in late spring and decreased in summer (P<0.05). In digestive glands, aluminum, bromine, cadmium, calcium, chromium, copper, iron, manganese, nickel, and zinc were detected more compared to adductor muscles (P<0...
July 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28595785/comparative-study-of-cardio-protective-effects-of-zinc-oxide-nanoparticles-and-zinc-sulfate-in-streptozotocin-induced-diabetic-rats
#10
Siamak Asri-Rezaei, Bahram Dalir-Naghadeh, Ali Nazarizadeh, Zahra Noori-Sabzikar
The cardio-protective effects of zinc oxide nanoparticles (Zn NPs) against diabetes-induced cardiopathy were evaluated and compared with zinc sulfate (ZnSO4). A total of 120 Wistar rats were randomly categorized as healthy and diabetic groups. Then, the 2 groups were classified in 5 subgroups. The animals received oral supplementations containing different Zn NP (ie, doses of 1, 3, and 10mg/kg) and ZnSO4 (30mg/kg) concentrations over 8 weeks. Blood and cardiac tissue samples were collected in the different time intervals and subjected to biochemical and histopathological analysis...
July 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28588597/protein-biochemistry-and-expression-regulation-of-cadmium-zinc-pumping-atpases-in-the-hyperaccumulator-plants-arabidopsis-halleri-and-noccaea-caerulescens
#11
Seema Mishra, Archana Mishra, Hendrik Küpper
P1B-ATPases are decisive for metal accumulation phenotypes, but mechanisms of their regulation are only partially understood. Here, we studied the Cd/Zn transporting ATPases NcHMA3 and NcHMA4 from Noccaea caerulescens as well as AhHMA3 and AhHMA4 from Arabidopsis halleri. Protein biochemistry was analyzed on HMA4 purified from roots of N. caerulescens in active state. Metal titration of NcHMA4 protein with an electrochromic dye as charge indicator suggested that HMA4 reaches maximal ATPase activity when all internal high-affinity Cd(2+) binding sites are occupied...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28588226/the-effects-of-brazilian-green-propolis-that-contains-flavonols-against-mutant-copper-zinc-superoxide-dismutase-mediated-toxicity
#12
Tomoyuki Ueda, Masatoshi Inden, Katsuhiro Shirai, Shin-Ichiro Sekine, Yuji Masaki, Hisaka Kurita, Kenji Ichihara, Takashi Inuzuka, Isao Hozumi
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective and progressive loss of motor neurons. The purpose of this study was to clarify effects of brazilian green propolis and the active ingredient against ALS-associated mutant copper-zinc superoxide dismutase (SOD1)-mediated toxicity. Ethanol extract of brazilian green propolis (EBGP) protected N2a cells against mutant SOD1-induced neurotoxicity and reduced aggregated mutant SOD1 by induction of autophagy. Kaempferide and kaempferol, the active ingredients of EBGP, also inhibited mutant SOD1-induced cell death and reduced the intracellular mutant SOD1 aggregates...
June 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28586731/cellular-interactions-of-zinc-oxide-nanoparticles-with-human-embryonic-kidney-hek-293-cells
#13
Reshma V G, Mohanan P V
Zinc oxide nanoparticles (ZnO NPs) have potential biomedical, industrial and commercial applications. So they constantly come into contact with the body parts during applications. Safety concerns about ZnO NPs are increasing today and yet only few reports are available about their toxicity in kidney cells. It is very essential to analyze the toxicity on kidney because kidney plays a decisive role in nanoparticles excretion. Therefore, the present study focuses on the interaction of ZnO NPs with human embryonic kidney 293 (HEK 293) cells in vitro...
May 31, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28585004/metallothionein-a-potential-link-in-the-regulation-of-zinc-in-nutritional-immunity
#14
REVIEW
Mohammad Tariqur Rahman, Muhammad Manjurul Karim
Nutritional immunity describes mechanisms for withholding essential transition metals as well as directing the toxicity of these metals against infectious agents. Zinc is one of these transition elements that are essential for both humans and microbial pathogens. At the same time, Zn can be toxic both for man and microbes if its concentration is higher than the tolerance limit. Therefore a "delicate" balance of Zn must be maintained to keep the immune cells surveilling while making the level of Zn either to starve or to intoxicate the pathogens...
June 5, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28579779/antibacterial-properties-and-toxicity-from-metallic-nanomaterials
#15
REVIEW
Gina V Vimbela, Sang M Ngo, Carolyn Fraze, Lei Yang, David A Stout
The era of antibiotic resistance is a cause of increasing concern as bacteria continue to develop adaptive countermeasures against current antibiotics at an alarming rate. In recent years, studies have reported nanoparticles as a promising alternative to antibacterial reagents because of their exhibited antibacterial activity in several biomedical applications, including drug and gene delivery, tissue engineering, and imaging. Moreover, nanomaterial research has led to reports of a possible relationship between the morphological characteristics of a nanomaterial and the magnitude of its delivered toxicity...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28578126/ultradeformable-liposome-loaded-with-zinc-phthalocyanine-and-ru-nh-nhq-tpy-no-3-for-photodynamic-therapy-by-topical-application
#16
Renata Galvão de Lima, Antonio Cláudio Tedesco, Roberto Santana da Silva, Margaret Jayne Lawrence
Ultradeformable liposomes (UDLs) as a drug delivery system (DDS), prepared from the unsaturated phospholipid, dioleylphosphocholine (DOPC), and containing the non-ionic surfactant Tween 20 as edge activator, have been explored as topical vehicles for zinc phthalocyanine (ZnPc) and the nitrosyl ruthenium complex [Ru(NH.NHq)(tpy)NO](3+) (RuNO) as a photosensitizers for co-generation of (1)O2 and NO as reactive species, respectively. However, in order to ensure that ZnPc was present in the UDLs in its monomeric form - essential for maximal ZnPc photophysical properties - it was necessary to replace 40wt% of the DOPC with the saturated phospholipid, dimyristoylphosphocholine (DMPC)...
May 31, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28576071/augmentation-of-the-cytotoxic-effects-of-zinc-oxide-nanoparticles-by-mtcp-conjugation-non-canonical-apoptosis-and-autophagy-induction-in-human-adenocarcinoma-breast-cancer-cell-lines
#17
Najmeh Mozdoori, Shahrokh Safarian, Nader Sheibani
Zinc oxide nanoparticles are very toxic, but their agglomeration reduces their lethal cytotoxic effects. Here we tested the hypothesis that conjugation of ZnO nanoparticles via Meso-Tetra (4-Carboxyphenyl) Porphyrin (MTCP) could provide electrostatic or steric stabilization of ZnO nanoparticles and increase their cytotoxic effects. The cytotoxicity and cell death induction were assessed using two human breast adenocarcinoma cell lines (MCF-7 and MDA-MB-468). The MTT results indicated that the toxicity of ZnO nanoparticles was significantly increased upon MTCP conjugation...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28574396/complex-heavy-metal-salts-effect-on-ganglion-nuclei-neurons-morphological-functions-in-adult-male-rats-cerebellar-cortex
#18
N Grintsova, N Glushchenko, M Dunaeva
In order to analyze the dynamics of morphological and morphometric nuclear rearrangements of cortical cerebellar Purkinje cells under prolonged exposure (for 90 days) on the body of copper sulfate, zinc and iron experiment was conducted on 48 white adult male rats weighing 200-250g, aged 5 -8 months. We used anatomic, morphometric, statistical and common methods of micro anatomical research method. It was found that the combined effect of copper sulfate, zinc and iron on the body has nuclear device ganglion neurons in the cerebellar cortex sufficiently expressive toxicity, which affects the state of neurons...
April 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28574163/heavy-metal-atpase-3-hma3-confers-cadmium-hypertolerance-on-the-cadmium-zinc-hyperaccumulator-sedum-plumbizincicola
#19
Huan Liu, Haixia Zhao, Longhua Wu, Anna Liu, Fang-Jie Zhao, Wenzhong Xu
Cadmium (Cd) is highly toxic to most organisms, but some rare plant species can hyperaccumulate Cd in aboveground tissues without suffering from toxicity. The mechanism underlying Cd detoxification by hyperaccumulators is interesting but unclear. Here, the heavy metal ATPase 3 (SpHMA3) gene responsible for Cd detoxification was isolated from the Cd/zinc (Zn) hyperaccumulator Sedum plumbizincicola. RNA interference (RNAi)-mediated silencing and overexpression of SpHMA3 were induced to investigate its physiological functions in S...
June 2, 2017: New Phytologist
https://www.readbyqxmd.com/read/28573081/comparative-proteomic-analysis-of-rat-bronchoalveolar-lavage-fluid-after-exposure-to-zinc-oxide-nanoparticles
#20
Yu-Min Juang, Han-Ju Chien, Cheng-Yu Yang, Hsiao-Chien Yeh, Tsun-Jen Cheng, Chien-Chen Lai
Zinc oxide nanoparticles (ZnO NPs) are one of the most widely used nanomaterials in consumer products and industrial applications. As a result of all these uses, this has raised concerns regarding their potential toxicity. We previously found that candidate markers of idiopathic pulmonary fibrosis and lung cancer were significantly up-regulated in rat bronchoalveolar lavage fluid (BALF) following exposure to ZnO NPs by using a liquid chromatography (LC)-based proteomic approach. To achieve comprehensive protein identification analysis, we conducted the two-dimensional gel electrophosis (2-DE)-based proteomic workflow to analyze the differences in BALF proteins from rats that had been exposed to a high dose of 35 nm ZnO NPs...
2017: Mass Spectrometry
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