keyword
MENU ▼
Read by QxMD icon Read
search

Zinc toxicity

keyword
https://www.readbyqxmd.com/read/28442704/discovery-of-an-enzyme-and-substrate-selective-inhibitor-of-adam10-using-an-exosite-binding-glycosylated-substrate
#1
Franck Madoux, Daniela Dreymuller, Jean-Phillipe Pettiloud, Radleigh Santos, Christoph Becker-Pauly, Andreas Ludwig, Gregg B Fields, Thomas Bannister, Timothy P Spicer, Mare Cudic, Louis D Scampavia, Dmitriy Minond
ADAM10 and ADAM17 have been shown to contribute to the acquired drug resistance of HER2-positive breast cancer in response to trastuzumab. The majority of ADAM10 and ADAM17 inhibitor development has been focused on the discovery of compounds that bind the active site zinc, however, in recent years, there has been a shift from active site to secondary substrate binding site (exosite) inhibitor discovery in order to identify non-zinc-binding molecules. In the present work a glycosylated, exosite-binding substrate of ADAM10 and ADAM17 was utilized to screen 370,276 compounds from the MLPCN collection...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28441607/toxicity-assessment-of-zno-decorated-au-nanoparticles-in-the-mediterranean-clam-ruditapes-decussatus
#2
Badreddine Sellami, Amine Mezni, Abdelhafidh Khazri, Imen Bouzidi, Wiem Saidani, David Sheehan, Hamouda Beyrem
The synthesis of hybrid nanomaterials has greatly increased in recent years due to their special physical and chemical properties. However, information regarding the environmental toxicity associated with these chemicals is limited, in particular in the aquatic environment. In the present study, an experiment was performed in which the marine bivalve (Ruditapes decussatus) was exposed for 14days to 2 concentrations of zinc oxide-decorated Au nanoparticles (Au-ZnONPs: Au-ZnONP50=50μg/L; Au-ZnONP100=100μg/L)...
April 15, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28440961/non-bactericidal-zinc-complexing-ligand-as-a-biofilm-inhibitor-structure-guided-contrasting-effect-on-staphylococcus-aureus-biofilm
#3
Vidushi Kapoor, Rajanikant Rai, Durairaj Thiyagarajan, Sandipan Mukherjee, Gopal Das, Ramesh Aiyagari
Zinc-complexing ligands are prospective antibiofilm agents, given the pivotal role of zinc in the formation of Staphylococcus aureus biofilm. To this end, the potential of a thiosemicarbazone (C1) and a benzothiazole-based ligand (C4) in the prevention of S. aureus biofilm formation was assessed. C1 displayed a bimodal activity as it hindered biofilm formation only at low concentrations and promoted biofilm growth at higher concentrations. In case of C4, a dose-dependent inhibition of S. aureus biofilm growth was observed...
April 25, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28440203/antimicrobial-biofilm-inhibitory-and-anti-infective-activity-of-metallic-nanoparticles-against-multi-drug-resistant-mrsa-and-pseudomonas-aeruginosa-pa01
#4
Jamuna Bai Ashwathanarayan, Ravishankar Rai Vittal
BACKGROUND: The emergence of drug resistant pathogens is a major concern to the scientific community. Novel approaches such as the use of functionalized nanomaterials with antimicrobial activity is required to treat infectious diseases. OBJECTIVE: In the present study, the metallic nanoparticles (iron, gold, zinc oxide and copper oxide) were evaluated for the antimicrobial, biofilm inhibitory and anti-infective activity against human pathogens methicillin resistant Staphylococcus aureus and Pseudomonas aeruginosa PA01...
April 24, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28438148/maternal-blood-cadmium-lead-and-arsenic-levels-nutrient-combinations-and-offspring-birthweight
#5
Yiwen Luo, Lauren E McCullough, Jung-Ying Tzeng, Thomas Darrah, Avner Vengosh, Rachel L Maguire, Arnab Maity, Carmen Samuel-Hodge, Susan K Murphy, Michelle A Mendez, Cathrine Hoyo
BACKGROUND: Cadmium (Cd), lead (Pb) and arsenic (As) are common environmental contaminants that have been associated with lower birthweight. Although some essential metals may mitigate exposure, data are inconsistent. This study sought to evaluate the relationship between toxic metals, nutrient combinations and birthweight among 275 mother-child pairs. METHODS: Non-essential metals, Cd, Pb, As, and essential metals, iron (Fe), zinc (Zn), selenium (Se), copper (Cu), calcium (Ca), magnesium (Mg), and manganese (Mn) were measured in maternal whole blood obtained during the first trimester using inductively coupled plasma mass spectrometry...
April 24, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28437768/glomeromycota-communities-survive-extreme-levels-of-metal-toxicity-in-an-orphan-mining-site
#6
I Sánchez-Castro, V Gianinazzi-Pearson, J C Cleyet-Marel, E Baudoin, D van Tuinen
Abandoned tailing basins and waste heaps of orphan mining sites are of great concern since extreme metal contamination makes soil improper for any human activity and is a permanent threat for nearby surroundings. Although spontaneous revegetation can occur, the process is slow or unsuccessful and rhizostabilisation strategies to reduce dispersal of contaminated dust represent an option to rehabilitate such sites. This requires selection of plants tolerant to such conditions, and optimization of their fitness and growth...
April 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28436678/nanotoxicity-modelling-and-removal-efficiencies-of-znonp-with-consortium
#7
Şeyda Fikirdeşici Ergen, Esra Üçüncü Tunca
In this paper the aim is to model the toxic effect of zinc oxide nanoparticles (ZnONP) and is to analyze the removal of ZnONP in aqueous medium by the consortium consisted of Daphnia magna and Lemna minor. Three separate test groups are formed: L. minor (L), D. magna (D) and L.minor+D.magna (L+D) and all these test groups are exposed to three different nanoparticle concentrations (0.3;3.0 and 30.0 mg L(-)(1)). Time-dependent, concentration-dependent and group-dependent removal efficiencies are statistically compared by non-parametric Mann-Whitney U test and statistically significant differences are observed...
April 24, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28435068/metal-metal-interaction-mediates-the-iron-induction-of-drosophila-mtnb
#8
Wenjia Qiang, Yunpeng Huang, Zhihui Wan, Bing Zhou
Metallothionein (MT) protein families are a class of small and universal proteins rich in cysteine residues. They are synthesized in response to heavy metal stresses to sequester the toxic ions by metal-thiolate bridges. Five MT family members, namely MtnA, MtnB, MtnC, MtnD and MtnE, have been discovered and identified in Drosophila. These five isoforms of MTs are regulated by metal responsive transcription factor dMTF-1 and play differentiated but overlapping roles in detoxification of metal ions. Previous researches have shown that Drosophila MtnB responds to copper (Cu), cadmium (Cd) and zinc (Zn)...
April 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28433709/pulmonary-pathobiology-induced-by-zinc-oxide-nanoparticles-in-mice-a-24-hour-and-28-day-follow-up-study
#9
Hsiao-Chi Chuang, Kai-Jen Chuang, Jen-Kun Chen, His-En Hua, Yen-Ling Shen, Wei-Neng Liao, Chii-Hong Lee, Chih-Hong Pan, Kuan-Yuan Chen, Kang-Yun Lee, Ta-Chih Hsiao, Tsun-Jen Cheng
Inhaled zinc oxide nanoparticles (ZnONPs) have high deposition rates in the alveolar region of the lungs; however, the adverse health effects of ZnONPs on the respiratory system are unclear. Herein, pathobiological responses of the respiratory system of mice that received intratracheal administration of ZnONPs were investigated by a combination of molecular and imaging (SPECT and CT) approaches. Also, normal BEAS-2B and adenocarcinoma A549 cells were used to confirm the results in mice. First, female BALB/c mice were administrated a series of doses of 20-nm ZnONPs and were compared to the phosphate-buffered saline control for 24-h and 28-day follow-up observations...
April 19, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28433597/prediction-of-toxicity-of-zinc-and-nickel-mixtures-to-artemia-sp-at-various-salinities-from-additivity-to-antagonism
#10
Évila Pinheiro Damasceno, Lívia Pitombeira de Figuerêdo, Marcionília Fernandes Pimentel, Susana Loureiro, Letícia Veras Costa-Lotufo
Few studies have examined the toxicity of metal mixtures to marine organisms exposed to different salinities. The aim of the present study was to investigate the acute toxicity of zinc and nickel exposures singly and in combination to Artemia sp. under salinities of 10, 17, and 35 psu. The mixture concentrations were determined according to individual toxic units (TUs) to follow a fixed ratio design. Zinc was more toxic than nickel, and both their individual toxicities were higher at lower salinities. These changes in toxicity can be attributed to the Biotic Ligand Model (BLM) rather than to metal speciation...
April 20, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28430390/chronic-toxicity-of-binary-metal-mixtures-of-cadmium-and-zinc-to-daphnia-magna
#11
Edgar Pérez, Tham C Hoang
The present study characterized the chronic effect of binary-metal mixtures of cadmium (Cd) and zinc (Zn) on Daphnia magna. The titration design was chosen to characterize the 21-d chronic effects of the binary-metal mixtures on survival, growth, reproduction, and metal accumulation in D. magna. Using this design, increasing concentrations of Zn (10, 20, 40, 80, 120, 160 and 200µg/L) were titrated against a constant concentration of 1.5µg/L Cd. The results demonstrated that Cd was highly toxic to D. magna...
April 21, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28429184/interactive-effects-of-salicylic-acid-and-nitric-oxide-in-alleviating-zinc-toxicity-of-safflower-carthamus-tinctorius-l
#12
Shahram Namdjoyan, Hossein Kermanian, Ali Abolhasani Soorki, Sedigheh Modarres Tabatabaei, Nazli Elyasi
The purpose of this study was to assess the possible protective role of exogenous salicylic acid (SA), sodium nitroprusside (SNP), a donor of nitric oxide, and their combination on 21-day-old safflower (Carthamus tinctorius L.) seedlings grown under zinc (Zn) stress. The results revealed that exposure to 500 µM ZnSO4.7H2O for 10 days markedly reduced the root and shoot dry weights in Zn-treated plants, while the application of SA, SNP and specially SA + SNP significantly increased the root and shoot dry weights in seedlings subjected to Zn stress...
April 20, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28427888/dopamine-elevates-intracellular-zinc-concentration-in-cultured-rat-embryonic-cortical-neurons-through-the-camp-nitric-oxide-signaling-cascade
#13
Hui-Hsing Hung, Lung-Sen Kao, Pei-Shan Liu, Chien-Chang Huang, De-Ming Yang, Chien-Yuan Pan
Zinc ion (Zn(2+)), the second most abundant transition metal after iron in the body, is essential for neuronal activity and also induces toxicity if the concentration is abnormally high. Our previous results show that exposure of cultured cortical neurons to dopamine elevates intracellular Zn(2+) concentrations ([Zn(2+)]i) and induces autophagosome formation but the mechanism is not clear. In this study, we characterized the signaling pathway responsible for the dopamine-induced elevation of [Zn(2+)]i and the effect of [Zn(2+)]i in modulating the autophagy in cultured rat embryonic cortical neurons...
April 17, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28427443/benserazide-a-dopadecarboxylase-inhibitor-suppresses-tumor-growth-by-targeting-hexokinase-2
#14
Wei Li, Mengzhu Zheng, Shuangping Wu, Suyu Gao, Mei Yang, Zhimei Li, Qiuxia Min, Weiguang Sun, Lixia Chen, Guangya Xiang, Hua Li
BACKGROUND: Hexokinase (HK) is the rate-limiting enzyme in the first reaction of glycolysis. And Hexokinase 2 (HK2) is most closely related to malignant tumor which expresses at higher level compared with normal cells. HK2 plays a pivotal role in tumor initiation and maintenance, which provides a new target for cancer therapy. METHODS: Structure-based virtual ligand screening was used in hit identification from ZINC Drug Database. Microscale thermophoresis assay was performed to evaluate the binding affinity...
April 20, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28417309/effects-of-nano-zinc-on-biochemical-parameters-in-cadmium-exposed-rats
#15
Marzie Hejazy, Mohammad Kazem Koohi
Cadmium (Cd) is a toxic environmental and occupational pollutant with reported toxic effects on the kidneys, liver, lungs, bones, and the immunity system. Based on its physicochemical similarity to cadmium, zinc (Zn) shows protective effects against cadmium toxicity and cadmium accumulation in the body. Nano-zinc and nano-zinc oxide (ZnO), recently used in foods and pharmaceutical products, can release a great amount of Zn(2+) in their environment. This research was carried out to investigate the more potent properties of the metal zinc among sub-acute cadmium intoxicated rats...
April 17, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28416395/the-early-history-of-manganese-and-the-recognition-of-its-neurotoxicity-1837-1936
#16
Paul D Blanc
The history of the biomedical recognition manganese-caused neurotoxicity mirrors changing technologies as much as it does the ontology of parkinsonism. The initial 1837 report of manganese-induced neurologic injury was made by John Couper, a university-based physician in Scotland. He made clear that the outbreak occurred among workers at the Charles Tennant bleach manufactory in the environs of Glasgow. The relatively new technology of chlorine generation using manganese accounted for the novel exposure involved...
April 14, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28415385/antitubercular-activity-of-zno-nanoparticles-prepared-by-solution-combustion-synthesis-using-lemon-juice-as-bio-fuel
#17
Prashanth Gopala Krishna, Prashanth Paduvarahalli Ananthaswamy, Priyanka Trivedi, Vinita Chaturvedi, Nagabhushana Bhangi Mutta, Ananda Sannaiah, Amani Erra, Tejabhiram Yadavalli
In this study, we report the synthesis, structural and morphological characteristics of zinc oxide (ZnO) nanoparticles using solution combustion synthesis method where lemon juice was used as the fuel. In vitro anti-tubercular activity of the synthesized ZnO nanoparticles and their biocompatibility studies, both in vitro and in vivo were carried out. The synthesized nanoparticles showed inhibition of Mycobacterium tuberculosis H37Ra strain at concentrations as low as 12.5μg/mL. In vitro cytotoxicity study performed with normal mammalian cells (L929, 3T3-L1) showed that ZnO nanoparticles are non-toxic with a Selectivity Index (SI) >10...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28414159/in-vitro-toxicological-effects-of-zinc-containing-nanoparticles-with-different-physico-chemical-properties
#18
Oskari Uski, Tiina Torvela, Olli Sippula, Tommi Karhunen, Hanna Koponen, Sirpa Peräniemi, Pasi Jalava, Mikko Happo, Jorma Jokiniemi, Maija-Riitta Hirvonen, Anna Lähde
Nanomaterials (NM) exhibit novel physicochemical properties that determine their interaction with biological substrates and processes. Recent nano-technological advances are leading to wide usage of metallic nanoparticles (NPs) in various fields. However, the increasing use of NPs has led to their release into environment and the toxicity of NPs on human health has become a concern. Moreover, there are inadvertently generated metallic NPs which are formed during various human activities (e.g. metal processing and energy production)...
April 14, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28413723/physiological-effects-of-five-different-marine-natural-organic-matters-noms-and-three-different-metals-cu-pb-zn-on-early-life-stages-of-the-blue-mussel-mytilus-galloprovincialis
#19
Lygia Sega Nogueira, Adalto Bianchini, Scott Smith, Marianna Basso Jorge, Rachael L Diamond, Chris M Wood
Metals are present in aquatic environments as a result of natural and anthropogenic inputs, and may induce toxicity to organisms. One of the main factors that influence this toxicity in fresh water is natural organic matter (NOM) but all NOMs are not the same in this regard. In sea water, possible protection by marine NOMs is not well understood. Thus, our study isolated marine NOMs by solid-phase extraction from five different sites and characterized them by excitation-emission fluorescence analysis-one inshore (terrigenous origin), two offshore (autochthonous origin), and two intermediate in composition (indicative of a mixed origin)...
2017: PeerJ
https://www.readbyqxmd.com/read/28413265/zinc-toxicity-stimulates-microbial-production-of-extracellular-polymers-in-a-copiotrophic-acid-soil
#20
Marc Redmile-Gordon, Lin Chen
The production of extracellular polymeric substances (EPS) is crucial for biofilm structure, microbial nutrition and proximal stability of habitat in a variety of environments. However, the production patterns of microbial EPS in soils as affected by heavy metal contamination remain uncertain. Here we investigate the extracellular response of the native microbial biomass in a grassland soil treated with refined glycerol or crude unrefined biodiesel co-product (BCP) with and without ZnCl2. We extracted microbial EPS and more readily soluble microbial products (SMP), and quantified total polysaccharide, uronic acid, and protein content in these respective extracts...
April 2017: International Biodeterioration & Biodegradation
keyword
keyword
90507
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"