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Zinc toxicity

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https://www.readbyqxmd.com/read/29785603/trace-and-macro-elements-in-the-femoral-bone-as-indicators-of-long-term-environmental-exposure-to-toxic-metals-in-european-brown-bear-ursus-arctos-from-croatia
#1
Maja Lazarus, Tatjana Orct, Slaven Reljić, Marija Sedak, Nina Bilandžić, Jasna Jurasović, Đuro Huber
We explored the long-term accumulation of aluminium, strontium, cadmium and lead in the compact and trabecular bone of the femoral epiphysis, metaphysis and diaphysis in 41 brown bears (Ursus arctos) from Croatia. Also, we assessed their influence on macro and trace elements (sodium, magnesium, phosphorus, potassium, calcium, manganese, iron, cobalt, copper, zinc and barium) in bears' bone. There were no sex differences in element levels in general, while age was associated with bone length and levels of all elements, except for cadmium...
May 21, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29785440/an-immunoconjugated-up-conversion-nanocomplex-for-selective-imaging-and-photodynamic-therapy-against-her2-positive-breast-cancer
#2
Gonzalo Ramírez-García, Sandeep S Panikar, Tzarara López-Luke, Valeria Piazza, Miguel Angel Honorato-Colin, Tanya Camacho-Villegas, Rodolfo Hernández-Gutiérrez, Elder De la Rosa
Photodynamic therapy represents a very attractive therapeutic tool considered to be effective, minimally invasive and minimally toxic. However, conventional photodynamic therapy actually has two main constraints: the limited penetration depth of visible light needed for its activation, and the lack of selectivity. Considering this, this work reports the synthesis and evaluation of a novel nanoconjugate for imaging and selective photodynamic therapy against HER2-positive breast cancer, a particularly aggressive form of the disease...
May 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29785068/molecular-dynamics-simulation-mds-analysis-of-vibrio-cholerae-toxt-virulence-factor-complexed-with-docked-potential-inhibitors
#3
Ibrahim Torktaz, Ali Najafi, Reza Golmohamadi, Sorour Hassani
The ToxT transcription factor mediates the transcription of the two major virulence factors in Vibrio cholerae. It has a DNA binding domain made of α4, α5, α6, α7, α8, α9 and α10 helices that is responsible for the transcription of virulence genes. Therefore, it is of interest to screen ToxT against the ZINC ligand database containing data for a million compounds. The QSAR model identified 40 top hits for ToxT. Two target protein complexes with ligands Lig N1 and Lig N2 with high score were selected for molecular dynamics simulation...
2018: Bioinformation
https://www.readbyqxmd.com/read/29783111/polymeric-nanocomposites-for-the-removal-of-acid-red-52-dye-from-aqueous-solutions-synthesis-characterization-kinetic-and-isotherm-studies
#4
A Gouthaman, Raja S Azarudeen, A Gnanaprakasam, V M Sivakumar, M Thirumarimurugan
Polymeric nanocomposites polyaniline-polyvinylpyrrolidone (PAPV) and polyaniline-polyvinylpyrrolidone-neodymium/zinc oxide (PAPV-NZO) were synthesized for the effective dye removal through adsorption process. Neodymium doped zinc oxide (NZO) with various proportions of neodymium were prepared by chemical co-precipitation method and incorporated into the copolymer matrix via oxidative polymerization technique. NZO nanoparticles were characterized by X-ray diffraction (XRD) and the morphological features, and functional group linkages of the PAPV-NZO were confirmed by scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR) analyses...
May 18, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29778679/efficient-metal-adsorption-and-microbial-reduction-from-rawal-lake-wastewater-using-metal-nanoparticle-coated-cotton
#5
Attarad Ali, Ayesha Gul, Abdul Mannan, Muhammad Zia
This study was designed to investigate removal of toxic metals and reduction of bacterial count from Rawal Lake wastewater with novel nanocomposite sorbents. Iron, zinc and silver oxide nanoparticles (NPs) were attached on cotton. The nanocomposites (iron NPs on cotton (FeCt), zinc NPs on cotton (ZnCt) and silver NPs on cotton (AgCt)) were characterized by FTIR, XRD and SEM, which showed successful adsorption of 10-30 nm size nanoparticles. Batch experiments were performed to determine the adsorption capacity of nanocomposite for metal removal...
May 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29776592/response-to-metals-treatment-of-fra1-a-member-of-the-ap-1-transcription-factor-family-in-p-lividus-sea-urchin-embryos
#6
Roberta Russo, Rosa Bonaventura, Marco Chiaramonte, Caterina Costa, Valeria Matranga, Francesca Zito
Lithium (Li), Nickel (Ni), and Zinc (Zn) are metals normally present in the seawater, although they can have adverse effects on the marine ecosystem at high concentrations by interfering with many biological processes. These metals are toxic for sea urchin embryos, affecting their morphology and developmental pathways. In particular, they perturb differently the correct organization of the embryonic axes (animal-vegetal, dorso-ventral): Li is a vegetalizing agent and Ni disrupts the dorso-ventral axis, while Zn has an animalizing effect...
May 5, 2018: Marine Environmental Research
https://www.readbyqxmd.com/read/29774338/trace-metals-in-oysters-molecular-and-cellular-mechanisms-and-ecotoxicological-impacts
#7
REVIEW
Wen-Xiong Wang, Jie Meng, Nanyan Weng
Oysters are important benthic bivalves in coastal and estuarine environments. They are widely farmed due to their rapid growth and taste; they are also widely applied in environmental monitoring of coastal pollution due to their accumulation of contaminants. Most importantly, oysters are among the few marine organisms that are considered to be hyper-accumulators of many toxic metals, such as cadmium, copper and zinc. As such, there is a tremendous call to study the interactions between metals and oysters, especially due to the increasing metal pollution in many coastal and estuarine waters...
May 18, 2018: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29773402/hydroxypropylmethyl-cellulose-hpmc-crosslinked-chitosan-ch-based-scaffolds-containing-bioactive-glass-bg-and-zinc-oxide-zno-for-alveolar-bone-repair
#8
Rabia Zeeshan, Zeeshan Mutahir, Haffsah Iqbal, Moazzam Ali, Farasat Iqbal, Kashif Ijaz, Faiza Sharif, Asma Tufail Shah, Aqif Anwar Chaudhry, Muhammad Yar, Shifang Luan, Ather Farooq Khan, Ihtesham-Ur-Rehman
The success of a dental implant relies on the presence of an optimal alveolar ridge. The aim of this study was to fabricate HPMC crosslinked chitosan based scaffolds for alveolar bone repair. Our results indicated that HPMC crosslinked CH/BG foams presented better morphological structure (132-90.5 μm) and mechanical responses (0.451 MPa with 100 mg BG) as confirmed by SEM analysis and fatigue testing respectively. Cytotoxicity analysis at day 2, 4 and 8 demonstrated that all composites were non-toxic and supported cellular viability...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29773372/bionanocomposites-materials-for-food-packaging-applications-concepts-and-future-outlook
#9
REVIEW
Ahmed M Youssef, Samah M El-Sayed
Bionanocomposites materials open a chance for the usage of novel, high performance, lightweight, and ecofriendly composite materials making them take place the traditional non-biodegradable plastic packaging materials. Biopolymers like polysaccharides such as chitosan (CS), carboxymethyl cellulose (CMC), starch and cellophane could be used to resolve environmental hazards owing to their biodegradability and non-toxicity. In addition these advantages, polysaccharides have some disadvantages for example poor mechanical properties and low resistance to water...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29772746/design-synthesis-and-biological-evaluation-of-benzimidazole-derived-biocompatible-copper-ii-and-zinc-ii-complexes-as-anticancer-chemotherapeutics
#10
Mohamed F AlAjmi, Afzal Hussain, Md Tabish Rehman, Azmat Ali Khan, Perwez Alam Shaikh, Rais Ahmad Khan
Herein, we have synthesized and characterized a new benzimidazole-derived "BnI" ligand and its copper(II) complex, [Cu(BnI)₂], 1 , and zinc(II) complex, [Zn(BnI)₂], 2 , using elemental analysis and various spectroscopic techniques. Interaction of complexes 1 and 2 with the biomolecules viz. HSA (human serum albumin) and DNA were studied using absorption titration, fluorescence techniques, and in silico molecular docking studies. The results exhibited the significant binding propensity of both complexes 1 and 2 , but complex 1 showed more avid binding to HSA and DNA...
May 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29761886/zinc-toxicity-to-daphnia-magna-in-a-two-species-microcosm-can-be-predicted-from-single-species-test-data-the-effects-of-phosphorus-supply-and-ph
#11
Andreas Fettweis, Karel De Schamphelaere, Erik Smolders
Ecological interactions and abiotic stress factors may significantly affect species sensitivities to toxicants and these are not incorporated in standard single species tests. This study tests the hypothesis if a model, calibrated solely on single species data, can explain abiotic stress factors in a two-species microcosm, a test applied to the effects of nutritional stress (phosphorus (P)-limitation) on zinc (Zn) toxicity to Daphnia magna. A population model was developed based on P- and Zn-dependent algal and daphnid growth...
May 15, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29758197/berberine-and-zinc-oxide-based-nanoparticles-for-the-chemo-photothermal-therapy-of-lung-adenocarcinoma
#12
Sungyun Kim, Song Yi Lee, Hyun-Jong Cho
Organic/inorganic hydrid nanoparticles (NPs) composed of berberine (BER) and zinc oxide (ZnO) were developed for the therapy of lung cancers. Without the use of pharmaceutical excipients, NPs were fabricated with only dual anticancer agents (BER and ZnO) by facile blending method. The mean weight ratio between BER and ZnO in BER-ZnO NPs was 39:61 in this study. BER-ZnO NPs dispersed in water exhibited 200-300 nm hydrodynamic size under 5 mg/mL concentration. The exposure of both BER and ZnO in the outer layers of BER-ZnO NPs was identified by X-ray photoelectron spectroscopy analysis...
May 11, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29757950/changes-in-arsenic-copper-iron-manganese-and-zinc-levels-resulting-from-the-application-of-poultry-litter-to-agricultural-soils
#13
Richard D Foust, Michael Phillips, Killian Hull, Dariia Yehorova
Twelve applications of poultry litter were made to a 2.1-ha field located in the Shenandoah Valley of Virginia, United States (USA), between March 1999 and August 2014. The field was planted with bermudagrass ( Cynodon dactylon ) and used as a pasture on an active farm. Copper, iron, manganese, zinc, and arsenic concentrations in the poultry litter were measured, and the application rates of these metals were calculated. The median application rates were: Cu, 1.32 kg/ha, Fe, 5.57 kg/ha, Mn, 1.80 kg/ha, Zn, 1...
May 14, 2018: Toxics
https://www.readbyqxmd.com/read/29754050/sargassum-wightii-synthesized-zno-nanoparticles-from-antibacterial-and-insecticidal-activity-to-immunostimulatory-effects-on-the-green-tiger-shrimp-penaeus-semisulcatus
#14
Ramachandran Ishwarya, Baskaralingam Vaseeharan, Suganya Subbaiah, Abdul Khudus Nazar, Marimuthu Govindarajan, Naiyf S Alharbi, Shine Kadaikunnan, Jamal M Khaled, Mohammed N Al-Anbr
The green synthesis of metal nanoparticles using phytochemical from marine seaweeds is a fast-growing research field in nanotechnology. Here, the biosynthesis of zinc oxide nanoparticles was achieved using the hot water extract of Sargassum wightii. The hot water extract prepared from S. wightii (H Sw) and ZnO NPs were studied by UV-visible and FTIR spectroscopy, SEM and XRD. Then, both products were evaluated for antibiofilm activity towards aquatic pathogens. The nanoparticles' immunostimulating potential on green tiger prawns, Penaeus semisulcatus was studied through immersion and dietary administration...
May 3, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29752519/potential-toxic-metal-accumulation-in-soil-forage-and-blood-plasma-of-buffaloes-sampled-from-jhang-pakistan
#15
Zafar Iqbal Khan, Ilker Ugulu, Sara Umar, Kafeel Ahmad, Naunain Mehmood, Asma Ashfaq, Humayun Bashir, Muhammad Sohail
This study was conducted to determine the concentration of toxic metals in soil, forage and blood plasma of lactating and non-lactating buffaloes in the district Jhang, Punjab, Pakistan. Soil samples were collected from varying distances from the road side. Plasma separation was achieved by centrifugation. The concentration of arsenic (As), selenium (Se), cadmium (Cd), chromium (Cr), iron (Fe), zinc (Zn), copper (Cu) and cobalt (Co) were determined by using Atomic Absorption Spectrophotometer. The results of the study showed that the mean As, Se and Cd concentrations in soil samples were lower while Cr, Fe, Zn, Cu and Co were higher than the official guidelines...
May 12, 2018: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29752110/evaluation-of-nano-hydrogel-composite-based-on-gelatin-ha-cs-suffused-with-asiatic-acid-zno-and-cuo-nanoparticles-for-second-degree-burns
#16
Thanusha A V, Amit Kumar Dinda, Veena Koul
In the present work, a hydrogel platform composed of biopolymer gelatin, and glycosaminoglycan's (Hyaluronic acid and Chondroitin sulfate) incorporated with Asiatic acid (a triterpenoid) and nanoparticles (Zinc oxide and Copper oxide) has been designed and developed to find out the efficacy of healing in second degree burn wounds in Wistar rats. The developed hydrogel composite has been characterized by physico-chemical methods such as; SEM, swelling, mechanical strength, degradation and drug release kinetics...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29751566/improvement-of-adhesion-properties-and-corrosion-resistance-of-sol-gel-coating-on-zinc
#17
Pauline Savignac, Marie-Joëlle Menu, Marie Gressier, Bastien Denat, Yacine El Khadir, Stephan Manov, Florence Ansart
Corrosion is a major problem for durability of many metals and alloys. Among the efficient classical surface treatments, chromate-based treatments must be banished from industrial use due to their toxicity. At the same time, sol-gel routes have demonstrated high potential to develop an efficient barrier effect against aggressive environments. By this process, the anti-corrosion property can be also associated to others in the case of the development of multi-functional hybrid coatings. In this paper, the main goal is precisely to improve both the corrosion resistance and the adhesion properties of phosphated zinc substrates by the deposition of a hybrid (organic-inorganic) sol-gel layer...
May 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29738953/design-and-biological-evaluation-of-tetrahydro-%C3%AE-carboline-derivatives-as-highly-potent-histone-deacetylase-6-hdac6-inhibitors
#18
Michel Leonhardt, Andreas Sellmer, Oliver H Krämer, Stefan Dove, Sigurd Elz, Birgit Kraus, Mandy Beyer, Siavosh Mahboobi
Various diseases are related to epigenetic modifications. Histone deacetylases (HDACs) and histone acetyl transferases (HATs) determine the pattern of histone acetylation, and thus are involved in the regulation of gene expression. First generation histone deacetylase inhibitors (HDACi) are unselective, hinder all different kinds of zinc dependent HDACs and additionally cause several side effects. Subsequently, selective HDACi are gaining more and more interest. Especially, selective histone deacetylase 6 inhibitors (HDAC6i) are supposed to be less toxic...
April 26, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29730716/metal-and-isotope-analysis-of-bird-feathers-in-a-contaminated-estuary-reveals-bioaccumulation-biomagnification-and-potential-toxic-effects
#19
L D Einoder, C K MacLeod, C Coughanowr
The Derwent estuary, in south east Tasmania, is highly contaminated with heavy metals, mainly due to past industrial pollution. This study sought to determine the extent of contamination, bioaccumulation, and biomagnification in the resident bird community and therefore to infer the potential for adverse effects in birds. Thirteen metals were measured from breast feathers (n = 51 individuals) of eight sympatric species of aquatic bird. Stable carbon (δ13 C) and nitrogen (δ15 N) isotopes were used to identify dietary sources of contaminants, trophic level, and potential biomagnification through food chains...
May 5, 2018: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29729541/comparative-uptake-study-of-arsenic-boron-copper-manganese-and-zinc-from-water-by-different-green-microalgae
#20
Ricardo Saavedra, Raúl Muñoz, María Elisa Taboada, Marisol Vega, Silvia Bolado
This work represents a comparative uptake study of the toxic elements arsenic, boron, copper, manganese and zinc in monometallic and multimetallic solutions by four green microalgae species (Chlamydomonas reinhardtii, Chlorella vulgaris, Scenedesmus almeriensis and an indigenous Chlorophyceae spp.), evaluating the effect of pH and contact time. Maximum removal efficiencies for each toxic element were 99.4% for Mn (C. vulgaris, pH 7.0, 3 h), 91.9% for Zn (Chlorophyceae spp., pH 5.5, 3 h), 88% for Cu (Chlorophyceae spp...
April 26, 2018: Bioresource Technology
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