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Zinc toxicity

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https://www.readbyqxmd.com/read/28733845/genome-wide-identification-in-silico-characterization-and-expression-analysis-of-zip-like-genes-from-trichomonas-vaginalis-in-response-to-zinc-and-iron
#1
K G Fernández-Martín, M E Alvarez-Sánchez, V E Arana-Argáez, L C Alvarez-Sánchez, J C Lara-Riegos, J C Torres-Romero
Trace elements such as Zinc and Iron are essential components of metalloproteins and serve as cofactors or structural elements for enzymes involved in several important biological processes in almost all organisms. Because either excess or insufficient levels of Zn and Fe can be harmful for the cells, the homeostatic levels of these trace minerals must be tightly regulated. The Zinc regulated transporter, Iron regulated transporter-like Proteins (ZIP) comprise a diverse family, with several paralogues in diverse organisms and are considered essential for the Zn and Fe uptake and homeostasis...
July 21, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28733784/environmental-impact-of-coal-mining-and-coal-seam-gas-production-on-surface-water-quality-in-the-sydney-basin-australia
#2
A Ali, V Strezov, P Davies, I Wright
The extraction of coal and coal seam gas (CSG) will generate produced water that, if not adequately treated, will pollute surface and groundwater systems. In Australia, the discharge of produced water from coal mining and related activities is regulated by the state environment agency through a pollution licence. This licence sets the discharge limits for a range of analytes to protect the environment into which the produced water is discharged. This study reports on the impact of produced water from coal mine activities located within or discharging into high conservation environments, such as National Parks, in the outer region of Sydney, Australia...
August 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28731302/lead-ii-binding-in-metallothioneins
#3
Daisy L Wong, Maureen E Merrifield-MacRae, Martin J Stillman
Heavy metal exposure has long been associated with metallothionein (MT) regulation and its functions. MT is a ubiquitous, cysteine-rich protein that is involved in homeostatic metal response for the essential metals zinc and copper, as well as detoxification of heavy metals; the most commonly proposed being cadmium. MT binds in vivo to a number of metals in addition to zinc, cadmium and copper, such as bismuth. In vitro, metallation with a wide range of metals (especially mercury, arsenic, and lead) has been reported using a variety of analytical methods...
April 10, 2017: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/28731294/the-bioinorganic-chemistry-of-lead-in-the-context-of-its-toxicity
#4
Wolfgang Maret
Owing to its abundance on earth and its multiple uses by humans, lead (Pb) is a major toxicant that has threatened human health for millennia and continues to do so. There is no safe level of exposure, necessitating a nuanced approach to its control in the food we consume, the water we drink, and the air we breathe. Turnover in soft tissues is within days. In contrast, lead accumulates in bone and turns over with a half-life of about 30 years, though it can be mobilized from bone under physiological and pathophysiological conditions of bone resorption...
April 10, 2017: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/28729858/toxin-antitoxin-systems-in-estuarine-synechococcus-strain-cb0101-and-their-transcriptomic-responses-to-environmental-stressors
#5
David Marsan, Allen Place, Daniel Fucich, Feng Chen
Bacterial toxin-antitoxin (TA) systems are genetic elements composed of a toxin gene and its cognate antitoxin, with the ability to regulate growth. TA systems have not previously been reported in marine Synechococcus or Prochlorococcus. Here we report the finding of seven TA system pairs (Type II) in the estuarine Synechococcus CB0101, and their responses of these TA genes to under different stress conditions, which include; nitrogen and phosphate starvation, phage infection, zinc toxicity, and photo-oxidation...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28728354/spatial-assessment-of-potential-ecological-risk-of-soil-heavy-metals-from-informal-e-waste-recycling-in-ghana
#6
Vincent Nartey Kyere, Klaus Greve, Sampson Atiemo, James Hawkins Ephraim
The rapidly increasing annual global volumes and the inherently valuable fractions of e-waste have created an avenue for individuals in Agbogbloshie, Accra, Ghana to make a living by utilizing unconventional, uncontrolled, primitive and crude procedures to recycle and recover valuable metals from these wastes. The current form of recycling procedures releases hazardous fractions such as heavy metals into the soils posing a significant risk to ecology and human health. 132 soil samples based on 100 m grid intervals were collected using handheld GPS and analyzed for Cadmium (Cd), chromium (Cr), copper (Cu), mercury (Hg), lead (Pb) and zinc (Zn) heavy metals...
July 10, 2017: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/28720288/potential-adverse-effects-of-engineered-nanomaterials-commonly-used-in-food-on-the-mirnome
#7
Jia Pei Lim, Gyeong Hun Baeg, Dinesh Kumar Srinivasan, S Thameem Dheen, Boon Huat Bay
The emergence of nanotechnology has greatly impacted our daily lives. Multiple products, including cosmetics, pharmaceuticals, electronics and food, are produced with incorporation of nanomaterials (NMs). Nanotechnology has yielded many promising benefits, yet, there remains much uncertainty about the hazards of NMs to humans. Hence, it is important to ensure safety of the users. Although many in vitro and in vivo studies have been carried out on the potential toxicity generated by NMs in food, its effects on the microRNA genome (miRNome) involved in the regulation of gene expression have been poorly understood...
July 15, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28715175/airborne-nanoparticle-release-and-toxicological-risk-from-metal-oxide-coated-textiles-toward-a-multi-scale-safe-by-design-approach
#8
Paride Mantecca, Kaja Kasemets, Archana Deokar, Ilana Perelshtein, Aharon Gedanken, Yeon Kyoung Bahk, Baharh Kianfar, Jing Wang
Nano metal oxides have been proposed as alternatives to Silver (Ag) nanoparticles (NPs) for antibacterial coatings. Here cotton and polyester-cotton fabrics were sonochemically coated with Zinc oxide (ZnO) ZnO and Copper oxide (CuO) CuO NPs. By varying the reaction solvent (water or ethanol), NPs with different sizes and shapes were synthesized. The cytotoxic and pro-inflammatory effects of studied NPs were investigated in vitro in human alveolar epithelial A549 and macrophage-like THP1 cells. To understand the potential respiratory impact of the NPs, the coated textiles were subjected to the abrasion tests and the released airborne particles were measured...
July 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28711828/thioglycolate-based-task-specific-ionic-liquids-metal-extraction-abilities-vs-acute-algal-toxicity
#9
Sonja Platzer, Raphlin Leyma, Sara Wolske, Wolfgang Kandioller, Esther Heid, Christian Schröder, Michael Schagerl, Regina Krachler, Franz Jirsa, Bernhard K Keppler
We studied the extraction behavior of two thioglycolate-based ionic liquids (ILs), for heavy metals from aqueous solutions; substances of interest were methyltrioctylammonium S-hexyl thioglycolate [N1888][C6SAc] and methyltrioctylphosphonium S-hexyl thioglycolate [P1888][C6SAc]. Theses ILs previously have shown very good extraction abilities towards cadmium and copper, therefore we investigated time-dependent metal removal experiments with aqueous solutions of cobalt(II), nickel(II) and zinc(II). The highest distribution ratio (RIL/Water) was determined for zinc (RIL/Water=2000)...
June 23, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28710929/tunable-emission-of-cu-mn-doped-znins-quantum-dots-via-dopant-interaction
#10
Jiatao Zhu, Shiliang Mei, Wu Yang, Guilin Zhang, Qiuhang Chen, Wanlu Zhang, Ruiqian Guo
In this work, transition metal ion- doped zinc-based quantum dots (QDs) are synthesized via a greener controllable method to avoid the toxicity of the traditional cadmium-based QDs and broaden the tunable emission. Herein, the tunable emission of Cu-doped ZnInS/ZnS core-shell QDs (Cu:ZnInS/ZnS) can cover from 500 to 620nm by varying the Cu dopant concentration from 1 to 20% and the maximum quantum yield can reach 49.8%. Based on the single-doped QDs, Cu,Mn co-doped ZnInS/ZnS core-shell QDs (Cu,Mn:ZnInS/ZnS) with a photoluminance (PL) quantum yield of 30...
June 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28710526/exposure-effects-and-absorption-of-lead-in-american-woodcock-scolopax-minor-a-review
#11
REVIEW
Amanda D French, Warren C Conway, Jaclyn E Cañas-Carrell, David M Klein
Due to long term declines of American Woodcock (Scolopax minor) and widespread distribution of environmentally available lead (Pb) throughout their geographic range, it is important to assess if Pb exposure is a potential contributor to these declines. Woodcock are exposed to Pb through various environmental sources and are known to exhibit relatively high bone-Pb concentrations. Absorption of Pb by birds, and woodcock specifically, is not well understood. Some studies show that interactions among calcium, phosphorus, iron, zinc, and vitamin D levels may play an important role in Pb absorption...
July 14, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28710015/bactericidal-impact-of-ag-zno-and-mixed-agzno-colloidal-nanoparticles-on-h37rv-mycobacterium-tuberculosis-phagocytized-by-thp-1%C3%A2-cell-lines
#12
Alireza Jafari, Nader Mosavari, Farahnaz Movahedzadeh, Saeedeh Jafari Nodooshan, Roya Safarkar, Rossella Moro, Morteza Kamalzadeh, Ali Majidpour, Mina Boustanshenas, Tahereh Mosavi
The purpose of this research project was to infection of human macrophages (THP-1) cell lines by H37Rv strain of Mycobacterium tuberculosis (H37RvMTB) and find out the ratio/dilution of mixture silver (Ag NPs) and zinc oxide nanoparticles (ZnO NPs) whose ability to eliminate phagocytized bacteria compared to rifampicin. The colloidal Ag NPs and ZnO NPs were synthesized and their characteristics were evaluated. The THP-1 cell lines were infected with different concentration of H37RvMTB. Next, the infected cells were treated with different ratios/dilutions of Ag NPs, ZnO NPs and rifampicin...
July 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28708298/the-ecotoxicity-of-zinc-and-zinc-containing-substances-in-soil-consideration-for-metal-moiety-approaches-and-organo-metal-complexes
#13
Ellyn Ritchie, Patrick Boyd, Annamaria Lawson-Halasz, Jalal Hawari, Stacey Saucier, Richard Scroggins, Juliska Princz
Within Canada, screening-level assessments for chemical substances are required in order to determine whether the substances pose a risk to human health and/or the environment, and as appropriate, risk management strategies. In response to the volume of metal and metal-containing substances, process efficiencies were introduced using a metal moiety approach, wherein substances that contain a common metal moiety are assessed simultaneously as a group, wherein the moiety of concern would consist of the metal ion...
July 14, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28704712/multipurpose-efficacy-of-zno-nanoparticles-coated-by-the-crustacean-immune-molecule-%C3%AE-1-3-glucan-binding-protein-toxicity-on-hepg2-liver-cancer-cells-and-bacterial-pathogens
#14
Arokiadhas Iswarya, Baskaralingam Vaseeharan, Mahalingam Anjugam, Balasubramaniem Ashokkumar, Marimuthu Govindarajan, Naiyf S Alharbi, Shine Kadaikunnan, Jamal M Khaled, Giovanni Benelli
The effective treatment of cancer and bacterial pathogens are two key challenges in modern nanomedicine. Here, zinc oxide nanoparticles (ZnO NPs) were fabricated using the crustacean immune molecule β-1, 3- glucan binding protein (Phβ-GBP, 100kDa) purified from the heamolymph of Paratelphusa hydrodromus. β-GBP coated zinc oxide nanoparticles (Phβ-GBP-ZnO NPs) were characterized by UV-vis spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and high resolution-transmission electron microscopy (HR-TEM) analyses...
June 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28704659/preheating-mitigates-cadmium-toxicity-in-zebrafish-livers-evidence-from-promoter-demethylation-gene-transcription-to-biochemical-levels
#15
Jia-Lang Zheng, Sai-Nan Guo, Shuang-Shuang Yuan, Hu Xia, Qing-Ling Zhu, Zhen-Ming Lv
The working hypothesis for this study was that moderate heat stress would alleviate the deleterious effects of subsequent cadmium (Cd) exposure on fish. Thus, zebrafish (Danio rerio) were subjected to water maintained at 26°C and 34°C for 4days, and then exposed to 0 or 200μg/L Cd for 1 week at 26°C. Multiple indicators were measured from livers of zebrafish at different levels, including DNA, RNA, protein and enzymatic activity associated with oxidative stress, inflammation and metal transport. The ameliorative effect of preheatinging on Cd toxicity was demonstrated...
June 26, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28704512/a-role-for-the-drosophila-zinc-transporter-zip88e-in-protecting-against-dietary-zinc-toxicity
#16
Christopher D Richards, Coral G Warr, Richard Burke
Zinc absorption in animals is thought to be regulated in a local, cell autonomous manner with intestinal cells responding to dietary zinc content. The Drosophila zinc transporter Zip88E shows strong sequence similarity to Zips 42C.1, 42C.2 and 89B as well as mammalian Zips 1, 2 and 3, suggesting that it may act in concert with the apically-localised Drosophila zinc uptake transporters to facilitate dietary zinc absorption by importing ions into the midgut enterocytes. However, the functional characterisation of Zip88E presented here indicates that Zip88E may instead play a role in detecting and responding to zinc toxicity...
2017: PloS One
https://www.readbyqxmd.com/read/28699119/deposited-atmospheric-dust-as-influenced-by-anthropogenic-emissions-in-northern-china
#17
Yanli Lyu, Lianyou Liu, Lanlan Guo, Yanyan Yang, Zhiqiang Qu, Xia Hu, Guoming Zhang
Atmospheric particulate matter (PM) from multinatural and anthropogenic sources poses serious risk to human health and contaminates soil and water resources as it settles back to ground environment and ecosystem. In this study, dust deposition flux (DDF), pollution load index (PLI) of heavy metals, enrichment factor (EF), and settling flux (SF) of eighteen chemical elements were investigated in comparison with crustal composition to assess the influence of anthropogenic emission on PM in major northern Chinese cities...
August 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28693316/rapid-dissolution-of-zno-nanoparticles-induced-by-biological-buffers-significantly-impacts-cytotoxicity
#18
Josh Eixenberger, Catherine Anders, Rebecca Hermann, Raquel Brown, K M Reddy, Alex Punnoose, Denise Wingett
Zinc oxide nanoparticles (nZnO) are one of the most highly produced nanomaterials and are used in numerous applications including cosmetics and sunscreens despite reports demonstrating their cytotoxicity. Dissolution is viewed as one of the main sources of nanoparticle (NP) toxicity, however dissolution studies can be time-intensive to perform and complicated by issues such as particle separation from solution. Our work attempts to overcome some of these challenges by utilizing new methods using UV/vis and fluorescence spectroscopy to quantitatively assess nZnO dissolution in various biologically relevant solutions...
July 10, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28692912/effects-of-molybdenum-and-cadmium-on-the-oxidative-damage-and-kidney-apoptosis-in-duck
#19
Lele Shi, Huabin Cao, Junrong Luo, Ping Liu, Tiancheng Wang, Guoliang Hu, Caiying Zhang
Molybdenum (Mo) is an essential element for human beings and animals; however, high dietary intake of Mo can lead to adverse reactions. Cadmium (Cd) is one of the major transitional metals which has toxic effects in animals. To investigate the co-induced toxic effects of Mo and Cd on oxidative damage and kidney apoptosis in duck, 120 ducks were randomly divided into control group and 5 treatment groups which were treated with a commercial diet containing different dosages of Mo and Cd. Kidney samples were collected on the 60th and 120th days to determine the mRNA expression levels of ceruloplasmin (CP), metallothionein (MT), Bak-1, and Caspase-3 by quantitative RT-PCR...
July 7, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28690383/molecular-docking-based-screening-of-listeriolysin-o-for-improved-inhibitors
#20
Sara Ghafari, Matin Komeilian, Mohaddese Sadat Hashemi, Sareh Oushani, Garshasb Rigi, Behnam Rashidieh, Kamran Yarahmadi, Fatemeh Khoddam
Listeriolysine-O (LLO) is a 50KDa protein responsible for Listeria monocytogenes pathogenicity. The structure of LLO (PDB ID: 4CDB) with domains D1 to D4 is known. Therefore, it is of interest to identify conserved regions among LLO variants for destabilizing oligomerization (50 mer complex) of its monomers using appropriate inhibitors. Therefore, it is of interest to identify suitable inhibitors for inhibiting LLO. Previous reports suggest the use of flavanoids like compounds for inhibiting LLO. Our interest is to identify improved compounds to destabilize LLO oligomerization...
2017: Bioinformation
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