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Zinc toxicity

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https://www.readbyqxmd.com/read/29353168/zinc-and-lead-detoxifying-abilities-of-humic-substances-relevant-to-environmental-bacterial-species
#1
L V Perelomov, Binoy Sarkar, O I Sizova, K B Chilachava, A Y Shvikin, I V Perelomova, Y M Atroshchenko
The effect of humic substances (HS) and their different fractions (humic acids (HA) and hymatomelanic acids (HMA)) on the toxicity of zinc and lead to different strains of bacteria was studied. All tested bacteria demonstrated a lower resistance to zinc than lead showing minimum inhibitory concentrations of 0.1 - 0.3mM and 0.3-0.5mM, respectively. The highest resistance to lead was characteristic of Pseudomonas chlororaphis PCL1391 and Rhodococcus RS67, while Pseudomonas chlororaphis PCL1391 showed the greatest resistance to zinc...
January 17, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29335513/optimal-ranges-of-variables-for-an-effective-adsorption-of-lead-ii-by-the-agricultural-waste-pomelo-citrus-grandis-peels-using-doehlert-designs
#2
Xiao-Lan Yu, Yong He
The capacity of pomelo peels' adsorption on lead(II) from aqueous solutions without modifications was investigated and confirmed. Four variables in this study, pH, temperature, time and initial concentration of lead(II), significantly affected the adsorption rate of pomelo peels. The prediction model and optimal ranges of optimized variables were given by Doehlert designs, which made the selection of variables rapid, flexible and effortless to obtain an adsorption rate reaching 99.9% and 20 mg/L for initial lead(II) concentration, 3 for pH, 50 °C for temperature and 210 min for time was a choice...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29331911/enhanced-photocatalytic-degradation-of-sulfamethoxazole-by-zinc-oxide-photocatalyst-in-the-presence-of-fluoride-ions-optimization-of-parameters-and-toxicological-evaluation
#3
Amir Mirzaei, Laleh Yerushalmi, Zhi Chen, Fariborz Haghighat, Jianbo Guo
The presence of antibiotics in water bodies has received increasing attention since they are continuously introduced and detected in the environment and may cause unpredictable environmental hazards and risks. The photocatalytic degradation of sulfamethoxazole (SMX) by ZnO in the presence of fluoride ions (F-ZnO) was evaluated. The effects of operating parameters on the efficiency of SMX removal were investigated by using response surface methodology (RSM). Under the optimum condition, i.e. photocatalyst dosage = 1...
January 11, 2018: Water Research
https://www.readbyqxmd.com/read/29331836/effects-of-zno-nanoparticles-in-the-caspian-roach-rutilus-rutilus-caspicus
#4
K Khosravi-Katuli, G Lofrano, H Pak Nezhad, A Giorgio, M Guida, F Aliberti, A Siciliano, M Carotenuto, E Galdiero, E Rahimi, G Libralato
Most studies investigating the toxicity of zinc oxide nanoparticles (ZnO NPs) focused on the effect of size, whereas exposure concentration and duration remained poorly understood. In this study, the effect of acute and sub-acute exposures of ZnO NPs on Zn compartmentalization and biomarkers' expression were investigated in Rutilus rutilus caspicus (Caspian roach) considering various exposure scenarios: i) the assessment of the concentration-response curves and median lethal concentration (LC50); ii) the assessment of the effects of organisms exposed at LC50 value and one tenth of LC50 value of ZnO NPs suspensions for 4 d and 28 d, respectively; iii) the assessment of 14 d depuration period...
January 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29329085/an-integrated-approach-to-assess-the-impacts-of-zinc-pyrithione-at-different-levels-of-biological-organization-in-marine-mussels
#5
Lorna J Dallas, Andrew Turner, Tim P Bean, Brett P Lyons, Awadhesh N Jha
The mechanisms of sublethal toxicity of the antifouling biocide, zinc pyrithione (ZnPT), have not been well-studied. This investigation demonstrates that 14-d sublethal exposure to ZnPT (0.2 or 2 μM, alongside inorganic Zn and sea water controls) is genotoxic to mussel haemocytes but suggests that this is not caused by oxidative DNA damage as no significant induction of oxidised purines was detected by Fpg-modified comet assay. More ecologically relevant endpoints, including decreased clearance rate (CR), cessation of attachment and decreased tolerance of stress on stress (SoS), also showed significant response to ZnPT exposure...
December 27, 2017: Chemosphere
https://www.readbyqxmd.com/read/29328033/-elemental-status-of-patients-with-various-forms-of-vitiligo
#6
N I Tsiskarishvili, A Katsitadze, N V Tsiskarishvili, I Charischarishvili
Vitiligo is a multifactorial disease in which, in each specific case of its manifestation, different mechanisms of its pathogenesis and different levels of melanin formation in the skin can be involved. Skin is one of the most metabolically active organs. Carrying out a number of vital functions (barrier, protective, respiratory, excretory, metabolic, immune, etc.), it needs microelementss. Of the 92 naturally occurring chemical elements, 81 are found in the human body. Lack of the vital elements, leads to the emergence of diseases, which are based on deficiency, excess or imbalance of micro- and macroelements in the body...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29325617/wilson-disease-and-related-copper-disorders
#7
Matthew T Lorincz
Copper is a required cofactor for enzymes in critical metabolic pathways. Mutations in copper metabolism genes or abnormalities in copper metabolism result in disease from copper excess or deficiency. Wilson disease (WD) is an autosomal-recessive disease caused by mutations in the ATP7B gene which encodes a copper-transporting ATPase. Over 500 different WD mutations throughout the ATP7B gene have been described, most of which are missense mutations. Mutations in both ATP7B alleles result in abnormal copper metabolism and subsequent toxic accumulation of copper...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29324691/physiological-and-comparative-genomic-analysis-of-arthrobacter-sp-srs-w-1-2016-provides-insights-on-niche-adaptation-for-survival-in-uraniferous-soils
#8
Ashvini Chauhan, Ashish Pathak, Rajneesh Jaswal, Bobby Edwards Iii, Demario Chappell, Christopher Ball, Reyna Garcia-Sillas, Paul Stothard, John Seaman
Arthrobacter sp. strain SRS-W-1-2016 was isolated on high concentrations of uranium (U) from the Savannah River Site (SRS) that remains co-contaminated by radionuclides, heavy metals, and organics. SRS is located on the northeast bank of the Savannah River (South Carolina, USA), which is a U.S. Department of Energy (DOE) managed ecosystem left historically contaminated from decades of nuclear weapons production activities. Predominant contaminants within the impacted SRS environment include U and Nickel (Ni), both of which can be transformed microbially into less toxic forms via metal complexation mechanisms...
January 11, 2018: Genes
https://www.readbyqxmd.com/read/29324644/nanocomposite-of-half-fin-anchovy-hydrolysates-zinc-oxide-nanoparticles-exhibits-actual-non-toxicity-and-regulates-intestinal-microbiota-short-chain-fatty-acids-production-and-oxidative-status-in-mice
#9
Ru Song, Jianbin Yao, Qingqing Shi, Rongbian Wei
The nanocomposite of half-fin anchovy hydrolysates (HAHp) and zinc oxide nanoparticles (ZnO NPs) (named as HAHp(3.0)/ZnO NPs) demonstrated increased antibacterial activity compared to either HAHp(3.0) or ZnO NPs as per our previous studies. Also, reactive oxygen species (ROS) formation was detected in Escherichia coli cells after treatment with HAHp(3.0)/ZnO NPs. The aim of the present study was to evaluate the acute toxicity of this nanocomposite and to investigate its effect on intestinal microbiota composition, short-chain fatty acids (SCFAs) production, and oxidative status in healthy mice...
January 11, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29320235/a-limited-survey-of-metal-content-in-blue-jack-mackerel-trachurus-picturatus-obtained-from-markets-in-the-canary-islands
#10
Carmen Rubio, Laura Acosta, Gara Luis-González, Dailos González-Weller, Consuelo Revert, Arturo Hardisson, Ángel Gutiérrez
The levels of 20 metals (aluminum, boron, barium, calcium, cadmium, cobalt, chromium, copper, iron, potassium, lithium, magnesium, manganese, molybdenum, sodium, nickel, lead, strontium, vanadium, and zinc) were analyzed in muscle and liver tissue of Trachurus picturatus marketed in the Canary Islands (Spain) by using inductively coupled plasma optical emission spectrometry. In the liver samples, the mean concentrations in milligrams per kilogram wet weight (wt) of Al (14.7), B (0.99), Ba (1.64), Ca (314), Cd (2...
January 10, 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29310434/in-vitro-and-in-vivo-studies-on-biomedical-magnesium-low-alloying-with-elements-gadolinium-and-zinc-for-orthopaedic-implant-applications
#11
Dong Bian, Jiuxu Deng, Nan Li, Xiao Chu, Yang Liu, Wenting Li, Hong Cai, Peng Xiu, Yu Zhang, Zhenpeng Guan, Yufeng Zheng, Yuhui Kou, Baoguo Jiang, Rongshi Chen
Ternary magnesium alloys with low combined-addition of elements gadolinium and zinc were developed in the present work, with their microstructures, mechanical properties, in vitro degradation behaviors and cytotoxicity being systematically studied. Furthermore, Mg-1.8Zn-0.2Gd alloy, with the best in vitro performances, was implanted into Sprague Dawley rats to examine its in vivo degradation performances up to 6 months. It was found that Mg-1.8Zn-0.2Gd, composed of single α-Mg phase, owned excellent strength and toughness that were comparable to the CE marked MAGNEZIX®, the mischmetal added Mg alloy...
January 9, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29307117/genetic-mapping-of-quantitative-trait-loci-for-tuber-cadmium-and-zinc-concentration-in-potato-reveals-associations-with-maturity-and-both-overlapping-and-independent-components-of-genetic-control
#12
Molla F Mengist, Sheila Alves, Denis Griffin, Joanne Creedon, Mike J McLaughlin, Peter W Jones, Dan Milbourne
Cd is a toxic metal, whilst Zn is an essential for plant and human health. Both can accumulate in potato tubers. We examine the genetic control of this process. The aim of this study was to map quantitative trait loci (QTLs) influencing tuber concentrations of cadmium (Cd) and zinc (Zn). We developed a segregating population comprising 188 F1 progeny derived from crossing two tetraploid cultivars exhibiting divergent tuber-Cd-accumulation phenotypes. These progeny were genotyped using the SolCap 8303 SNP array, and evaluated for Cd, Zn, and maturity-related traits...
January 6, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29304456/impact-of-zinc-oxide-nanoparticles-and-ocean-acidification-on-antioxidant-responses-of-mytilus-coruscus
#13
Xizhi Huang, Yimeng Liu, Zekang Liu, Zihao Zhao, Sam Dupont, Fangli Wu, Wei Huang, Jianfang Chen, Menghong Hu, Weiqun Lu, Youji Wang
Increased production of engineered nanoparticles (NPs) has raised extensive concerns about the potential toxic effects on marine organisms. Extensive evidences documented the impact of ocean acidification (OA) on the physiology and fitness of bivalves. In the present study, we investigated the biochemical responses of the mussel Mytilus coruscus exposed to both nano-ZnO and low pH relevant for ocean acidification conditions for 14 d followed by a 7-d recovery period. Most biochemical indexes (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), acid phosphatase (ACP) and alkaline phosphatase (ALP)) measured in gills and hemocytes were increased when the mussels were subject to low pH or high concentration of nano-ZnO, suggesting oxidative stress responses...
December 29, 2017: Chemosphere
https://www.readbyqxmd.com/read/29299844/vacuolar-zinc-transporter-zrc1-is-required-for-detoxification-of-excess-intracellular-zinc-in-the-human-fungal-pathogen-cryptococcus-neoformans
#14
Minsu Cho, Guanggan Hu, Mélissa Caza, Linda C Horianopoulos, James W Kronstad, Won Hee Jung
Zinc is an important transition metal in all living organisms and is required for numerous biological processes. However, excess zinc can also be toxic to cells and cause cellular stress. In the model fungus Saccharomyces cerevisiae, a vacuolar zinc transporter, Zrc1, plays important roles in the storage and detoxification of excess intracellular zinc to protect the cell. In this study, we identified an ortholog of the S. cerevisiae ZRC1 gene in the human fungal pathogen Cryptococcus neoformans. Zrc1 was localized in the vacuolar membrane in C...
January 2018: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/29289694/the-size-of-zinc-oxide-nanoparticles-controls-its-toxicity-through-impairing-autophagic-flux-in-a549-lung-epithelial-cells
#15
Bin Wang, Jun Zhang, Chengzhi Chen, Ge Xu, Xia Qin, Yueling Hong, Diptiman D Bose, Feng Qiu, Zhen Zou
Zinc oxide nanoparticles (ZnONPs) widely used in various products, have been concerned with its impact on human health, in particular, on the risk of pulmonary toxicity. Our previous study indicated that ZnONPs could harness autophagy and impair the autophagic flux, which was positively linked to ZnONPs-induced toxicity. The objective of this study was to investigate whether ZnONPs-induced impairment of autophagic flux and cell death in lung epithelial cells is related to the size of ZnONPs. We demonstrate that ZnONPs with the average size of 50 nm could induce toxic effects in A549 lung epithelial cells, including accumulation of autophagosomes (the elevation of LC3B-II/LC3B-I ratio), impaired autophagic flux (the increase of p62 expression), the release of intracellular zinc ions (the increase of FluoZin-3 signal and ZnT1 mRNA expression), mitochondrial damage (the decrease of TMRE signal), lysosomal dysfunction (the aberrant expression of LAMP-2), oxidative stress (the increase of DCFH-DA signal and HO-1 expression) and cell death...
December 28, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29288979/in-vitro-genotoxic-effect-of-secondary-minerals-crystallized-in-rocks-from-coal-mine-drainage
#16
Adriane Perachi Nordin, Juliana da Silva, Claudia Telles de Souza, Liana A B Niekraszewicz, Johnny Ferraz Dias, Kátia da Boit, Marcos L S Oliveira, Ivana Grivicich, Ana Letícia Hilario Garcia, Luis Felipe Silva Oliveira, Fernanda Rabaioli da Silva
Coal processing generates a large volume of waste that can damage human health and the environment. Often these wastes produce acid drainage in which several minerals are crystallized (evaporites). This study aimed to identify secondary minerals, as well as the genotoxic potential of these materials. The samples were collected at two sites along the Rocinha River in Santa Catarina state (Brazil): (1) directly from the source of the acid drainage (evaporite 1), and (2) on the river bank (evaporite 2). The samples were characterized by X-ray diffraction and by particle-induced X-ray emission techniques...
December 16, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29284245/concentrations-of-selected-toxic-elements-in-ewe-%C3%A2-living-near-an-environmentally-loaded-area-of-eastern-part-of-slovakia
#17
Terézia Pošiváková, Rudolf Hromada, Katarína Veszelits Laktičová, Mária Vargová, Ľuboš Korytár, Jozef Švajlenka, Miroslav Húska, Elena Hatalová, Ján Pošivák, Róbert Klein
INTRODUCTION AND OBJECTIVE: Research focused on the monitoring of selected heavy metals in ewes' blood. Concentrations of selected toxic elements, lead, cadmium and zinc, in ewes living near an environmentally-loaded area, concerned 15 ewes (aged 3-4 years) in good physical condition, during the spring of 2014 and 2015 in the eastern part of Slovakia. The aim of the research was to determine the concentration of selected heavy metals and state the correlations of selected heavy metals in ewes' blood...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29281938/pharmacophore-based-virtual-screening-of-catechol-o-methyltransferase-comt-inhibitors-to-combat-alzheimer-s-disease
#18
Chirag N Patel, John J Georrge, Krunal M Modi, Moksha B Narechania, Daxesh P Patel, Frank J Gonzalez, Himanshu A Pandya
Alzheimer's disease (AD) is one of the most significant neurodegenerative disorders and its symptoms mostly appear in aged people. Catechol-o-methyltransferase (COMT) is one of the known target enzymes responsible for AD. With the use of 23 known inhibitors of COMT, a query has been generated and validated by screening against the database of 1500 decoys to obtain the GH score and enrichment value. The crucial features of the known inhibitors were evaluated by the online ZINC Pharmer to identify new leads from a ZINC database...
December 27, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29278808/acute-toxicity-uptake-and-elimination-of-zinc-oxide-nanoparticles-zno-nps-using-saltwater-microcrustacean-artemia-franciscana
#19
Mehrdad Sarkheil, Seyed Ali Johari, Hyo Jin An, Saba Asghari, Hye Seon Park, Eun Kyung Sohn, Il Je Yu
This study aims to evaluate the potential toxic effects of ZnO nanoparticles on Artemia franciscana nauplii. The ZnO NPs suspension was characterized by TEM, EDS and DLS techniques. Acute toxicity was investigated by exposure of nauplii to concentrations of 1, 5, 7.5, 10, 15, 20, 25 and 30 mg/L of ZnO NPs for 48 h and 96 h. The 96-h EC10 and EC50 values of ZnO NPs were found to be 1.39 mg/L and 4.86 mg/L respectively. The ZnO NPs suspensions did not cause any significant acute toxicity after 48 h of exposure, but the immobilization rate increase significantly compare to control group after 96 h (P < 0...
December 20, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29261711/efficient-visible-light-photocatalysis-of-benzene-toluene-ethylbenzene-and-xylene-btex-in-aqueous-solutions-using-supported-zinc-oxide-nanorods
#20
Jamal Al-Sabahi, Tanujjal Bora, Mohammed Al-Abri, Joydeep Dutta
Benzene, toluene, ethylbenzene and xylenes (BTEX) are some of the common environmental pollutants originating mainly from oil and gas industries, which are toxic to human as well as other living organisms in the ecosystem. Here we investigate photocatalytic degradation of BTEX under visible light irradiation using supported zinc oxide (ZnO) nanorods grown on glass substrates using a microwave assisted hydrothermal method. ZnO nanorods were characterized by electron microscopy, X-ray diffraction (XRD), specific surface area, UV/visible absorption and photoluminescence spectroscopy...
2017: PloS One
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