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Zinc toxicity

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https://www.readbyqxmd.com/read/28924031/cytoplasmic-copper-detoxification-in-salmonella-can-contribute-to-sodc-metalation-but-is-dispensable-during-systemic-infection
#1
Luke A Fenlon, James M Slauch
Salmonella Typhimurium is a leading cause of foodborne disease worldwide. Severe infections result from the ability of S. Typhimurium to survive within host immune cells, despite being exposed to various host antimicrobial factors. SodCI, a copper-zinc cofactored superoxide dismutase, is required to defend against phagocytic superoxide. SodCII, an additional periplasmic superoxide dismutase, although produced during infection, does not function in the host. Previous studies suggested that CueP, a periplasmic copper binding protein, facilitates acquisition of copper by SodCII...
September 18, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28923702/zinc-oxide-nanoparticles-synthesis-antiseptic-activity-and-toxicity-mechanism
#2
REVIEW
A Król, P Pomastowski, K Rafińska, V Railean-Plugaru, B Buszewski
Zinc oxide (ZnO), as a material with attractive properties, has attracted great interest worldwide, particularly owing to the implementation of the synthesis of nano-sized particles. High luminescent efficiency, a wide band gap (3.36eV), and a large exciton binding energy (60meV) has triggered intense research on the production of nanoparticles using different synthesis methods and on their future applications. ZnO nanomaterials can be used in industry as nano-optical and nano-electrical devices, in food packaging and in medicine as antimicrobial and antitumor agents...
August 26, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28919489/zinc-chloride-induced-trpa1-activation-does-not-contribute-to-toxicity-in-vitro
#3
Dirk Steinritz, Franziska Zehfuß, Bernhard Stenger, Annette Schmidt, Tanja Popp, Kai Kehe, Harald Mückter, Horst Thiermann, Thomas Gudermann
The hygroscopic zinc chloride (ZnCl2) is often used to generate smoke screens. Severe adverse pulmonary health effects have been associated with inhalation of ZnCl2 smokes. The underlying molecular toxicology is not known. Recent studies have shown that the Transient Receptor Potential Channel A1 (TRPA1) is important for sensing toxic chemicals. TRPA1 was shown to be activated by Zn(2+) which was linked to pain and inflammation. In the present study, we investigated whether TRPA1 activation contributes to ZnCl2-mediated toxicity in vitro...
September 14, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28919410/tetrabromobisphenol-a-disturbs-zinc-homeostasis-in-cultured-cerebellar-granule-cells-a-dual-role-in-neurotoxicity
#4
Elzbieta Zieminska, Anna Ruszczynska, Jerzy W Lazarewicz
The brominated flame retardant tetrabromobisphenol A (TBBPA) has recognized neurotoxic properties mediated by intracellular Ca(2+) imbalance and oxidative stress. Although these factors are known to trigger the release of Zn(2+) from intracellular stores, the effects of TBBPA on Zn(2+) homeostasis in neurons and the role of Zn(2+)in TBBPA neurotoxicity have not yet been studied. Therefore, we investigated zinc transients in primary cultures of rat cerebellar granule cells and assessed their involvement in TBBPA neurotoxicity...
September 14, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28918363/changes-in-zn-homeostasis-during-long-term-culture-of-primary-endothelial-cells-and-effects-of-zn-on-endothelial-cell-senescence
#5
Marco Malavolta, Laura Costarelli, Robertina Giacconi, Andrea Basso, Francesco Piacenza, Elisa Pierpaoli, Mauro Provinciali, Ogo A Ogo, Dianne Ford
Endothelial cell senescence and Zn nutritional status influence cardiovascular disease. The influence of Zn appears dichotomous, hence it is imperative to understand the relationship with cellular senescence to improve knowledge about the molecular and cellular basis of the disease. Here we aimed to determine: 1) the impact of chronic exposure to a moderately high dose of Zn on senescence of endothelial cells; 2) the changes in Zn homeostasis during the lifespan of primary cultured endothelial cells; and 3) the susceptibility of proliferating and senescent endothelial cells to cell death after short term exposure to increasing doses of Zn and of the Zn chelator TPEN...
September 13, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28915474/simultaneous-removal-of-cadmium-zinc-and-manganese-using-electrocoagulation-influence-of-operating-parameters-and-electrolyte-nature
#6
Longqian Xu, Guangzhu Cao, Xiaojun Xu, Shuli Liu, Zhengyang Duan, Changhua He, Yao Wang, Qihua Huang
In the present study, the influence of operating parameters and electrolyte nature on the simultaneous removal of toxic metals (cadmium, zinc and manganese) from synthetic smelting wastewater by batch electrocoagulation was investigated. This wastewater contained high concentrations of anion-cation electrolytes. Results indicated that the efficiency of heavy metals removal can be enhanced by increasing the solution pH and current density. The Fe-Fe electrode combination is more effective than the other combinations (Al-Al, Al-Fe and Fe-Al)...
September 12, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28914974/mucocutaneous-inflammation-in-the-ikaros-family-zinc-finger-1-ikzf1-keratin-5-specifc-transgenic-mice
#7
Mayumi Ueta, Junji Hamuro, Hiromi Nishigaki, Naomi Nakamura, Katsuhiko Shinomiya, Katsura Mizushima, Yuki Hitomi, Risa Tamagawa-Mineoka, Norihiko Yokoi, Yuji Naito, Katsushi Tokunaga, Norito Katoh, Chie Sotozono, Shigeru Kinoshita
BACKGROUND: Our genome-wide association study documented an association between cold medicine related Stevens-Johnson syndrome / toxic epidermal necrolysis (CM-SJS/TEN) and Ikaros Family Zinc Finger 1 (IKZF1). Few studies examined biological and pathological functions of IKZF1 in mucosal immunity. We hypothesized that IKZF1 contributes to the mucocutaneous inflammation. METHODS: Human skin and conjunctival tissues were obtained for immunohistological studies. Primary human conjunctival epithelial cells (PHCjECs) and adult human epidermal keratinocytes (HEKa) also used for gene expression analysis...
September 15, 2017: Allergy
https://www.readbyqxmd.com/read/28910732/degradation-of-toxic-pahs-in-water-and-soil-using-potassium-zinc-hexacyanoferrate-nanocubes
#8
Uma Shanker, Vidhisha Jassal, Manviri Rani
Polycyclic aromatic hydrocarbons (PAHs) the ubiquitous, persistent and carcinogenic environmental contaminants have raised concern worldwide. Recently, their removal methodologies are advanced after exploring nanomaterials. Therefore, degradation of selected toxic PAHs (3-5 rings) using potassium zinc hexacyanoferrate (KZnHCF) nanocubes was studied. Highly crystalline and sharp KZnHCF nanocubes (∼100 nm) were obtained by green route using sapindus mukorossi. In both water and soil, anthracene and phenanthrene were degraded to maximum extent (80-93%), whereas, the degradation of fluorene, chrysene and benzo (a) pyrene were ∼70-80%...
September 11, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28899791/toward-a-hierarchical-virtual-screening-and-toxicity-risk-analysis-for-identifying-novel-ca-xii-inhibitors
#9
Elmira Nazarshodeh, Sajjad Gharaghani
Carbonic anhydrase isoform XII (CA XII) is a potential target for cancer treatment. In this study, pharmacophore modeling, hierarchical virtual screening, and toxicity risk analysis were performed for identifying novel CA XII inhibitors. A pharmacophore model of two classes of CA XII inhibitors was generated. The pharmacophore model indicated the important features of inhibitors for the binding with the CA XII. The model was then utilized to screen the ZINC and CoCoCo databases for retrieving potential hit compounds of CA XII...
September 9, 2017: Bio Systems
https://www.readbyqxmd.com/read/28898751/treatment-of-model-solutions-and-wastewater-containing-selected-hazardous-metal-ions-using-a-chitin-lignin-hybrid-material-as-an-effective-sorbent
#10
Przemysław Bartczak, Łukasz Klapiszewski, Marcin Wysokowski, Izabela Majchrzak, Weronika Czernicka, Adam Piasecki, Hermann Ehrlich, Teofil Jesionowski
A chitin/lignin material with defined physicochemical and morphological properties was used as an effective adsorbent of environmentally toxic metals from model systems. Particularly significant is its use in the neutralization of real industrial wastes. The ions Ni(2+), Cu(2+), Zn(2+) and Pb(2+) were adsorbed on the functional sorbent, confirming the high sorption capacity of the newly obtained product, primarily due to the presence on its surface of numerous active functional groups from the component biopolymers...
September 9, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28894702/effects-of-hair-metals-on-body-weight-in-iranian-children-aged-20-to-36-months
#11
Mohsen Vigeh, Kazuhito Yokoyama, Takehisa Matsukawa, Atsuko Shinohara, Mamak Shariat, Katsumi Ohtani
BACKGROUND: Although the level of exposure to many toxic metals decreased recently, the adverse effects of these metals on children's growth and development remain a serious public health issue. METHODS: The present study was conducted in three teaching hospitals affiliated with Tehran University of Medical Sciences (Tehran, Iran) from Sep 2012 to Mar 2013. To study the relationship between metals and childhood growth, concentrations of zinc and several potentially toxic metals (lead, cadmium, antimony, cobalt, and molybdenum) were measured in scalp hair for 174 children, aged 20 to 36 months...
August 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28889277/neurodegeneration-induced-by-metals-in-caenorhabditis-elegans
#12
Felix Antunes Soares, Daiandra Almeida Fagundez, Daiana Silva Avila
Metals are a component of a variety of ecosystems and organisms. They can generally be divided into essential and nonessential metals. The essential metals are involved in physiological processes once the deficiency of these metals has been associated with diseases. Although iron, manganese, copper, and zinc are important for life, it has been evidenced that they are also involved in neuronal damage in many neurodegenerative disorders. Nonessential metals, which are metals without physiological functions, are present in trace or higher levels in living organisms...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28889271/neurotoxicity-of-metal-mixtures
#13
V M Andrade, M Aschner, A P Marreilha Dos Santos
Metals are the oldest toxins known to humans. Metals differ from other toxic substances in that they are neither created nor destroyed by humans (Casarett and Doull's, Toxicology: the basic science of poisons, 8th edn. McGraw-Hill, London, 2013). Metals are of great importance in our daily life and their frequent use makes their omnipresence and a constant source of human exposure. Metals such as arsenic [As], lead [Pb], mercury [Hg], aluminum [Al] and cadmium [Cd] do not have any specific role in an organism and can be toxic even at low levels...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28889262/inherited-disorders-of-manganese-metabolism
#14
Charles E Zogzas, Somshuvra Mukhopadhyay
While the neurotoxic effects of manganese were recognized in 1837, the first genetic disorder of manganese metabolism was described only in 2012 when homozygous mutations in SLC30A10 were reported to cause manganese-induced neurotoxicity. Two other genetic disorders of manganese metabolism have now been described - mutations in SLC39A14 cause manganese toxicity, while mutations in SLC39A8 cause manganese and zinc deficiency. Study of rare genetic disorders often provides unique insights into disease pathobiology, and the discoveries of these three inherited disorders of manganese metabolism are already transforming our understanding of manganese homeostasis, detoxification, and neurotoxicity...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28888463/brazil-nuts-nutritional-composition-health-benefits-and-safety-aspects
#15
REVIEW
Bárbara R Cardoso, Graziela B Silva Duarte, Bruna Z Reis, Silvia M F Cozzolino
Brazil nuts are among the richest selenium food sources, and studies have considered this Amazonian nut as an alternative for selenium supplementation. Besides selenium, Brazil nuts present relevant content of other micronutrients such as magnesium, copper, and zinc. The nutritional composition of nuts, also characterized by adequate fatty acid profile and high content of protein and bioactive compounds, has many health benefits. In the present review, we examine the nutritional composition of Brazil nuts, comparing it with other nuts, and describe the relevance of possible contaminants and metal toxicants observed in this nut for human health...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28887979/antibacterial-zinc-oxide-hybrid-with-gelatin-coating
#16
Jun Lin, Jianxun Ding, Yanfeng Dai, Xiaolei Wang, Junchao Wei, Yiwang Chen
ZnO has been widely investigated as important biomaterials and antibacterial materials. However, the aggregation of nanoparticles and its potential toxicity may hinder its final application. Herein, biocompatible gelatin chains were grafted on the surface of ZnO via mussel inspired method to prevent the aggregation of the ZnO nanoparticles. The in vitro test showed that the gelatin can greatly improve the biocompatibility of ZnO, while the antibacterial properties of ZnO against both E. coli and S. aureus were maintained...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28887685/isolation-of-a-fungus-pencicillium-sp-with-zinc-tolerance-and-its-mechanism-of-resistance
#17
Yue Teng, Xianzheng Du, Tao Wang, Chenyu Mi, Hongyan Yu, Luyi Zou
A zinc (Zn)-tolerant fungus, designated BC109-2, was isolated from rhizosphere soil and was identified as Penicillium janthinellum BC109-2 based on ITS sequence analysis. To understand its Zn tolerance mechanisms, a series of studies was carried out addressing the subcellular distribution of Zn, its chemical forms, and the antioxidant system (superoxide dismutase, catalase, peroxidase, glutathione reductase, glutathione S-transferase, reduced glutathione, oxidized glutathione and malondialdehyde) of the fungus...
September 8, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28886561/zinc-protects-against-cadmium-induced-toxicity-by-regulating-oxidative-stress-ions-homeostasis-and-protein-synthesis
#18
Jingmei Pan, Xinhe Huang, Yuxing Li, Ming Li, Ning Yao, Zhengdong Zhou, Xueru Li
The widespread environmental toxin cadmium (Cd) is associated with numerous human diseases. The essential trace element zinc (Zn) strongly counteracts Cd-induced toxicity; however, the mechanism is incompletely understood. Here, we conducted RNA sequencing and bioinformatics analyses to determine the global gene expression profiles of yeast cells exposed to Cd or Cd plus Zn. We identified 912 Cd-induced and 627 Cd plus Zn-induced differentially expressed genes (DEGs). Adding Zn during Cd exposure efficiently reversed the expression of 92...
August 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28883729/maternal-exposure-to-nanosized-titanium-dioxide-suppresses-embryonic-development-in-mice
#19
Fashui Hong, Yingjun Zhou, Xiaoyang Zhao, Lei Sheng, Ling Wang
Although nanoscale titanium dioxide (nano-TiO2) has been extensively used in industrial food applications and daily products for pregnant women, infants, and children, its potential toxicity on fetal development has been rarely studied. The main objective of this investigation was to establish the effects of maternal exposure of nano-TiO2 on developing embryos. Female imprinting control region mice were orally administered nano-TiO2 from gestational day 0 to 17. Our findings showed that Ti concentrations in maternal serum, placenta, and fetus were increased in nano-TiO2-exposed mice when compared to controls, which resulted in reductions in the contents of calcium and zinc in maternal serum, placenta, and fetus, maternal weight gain, placental weight, fetal weight, number of live fetuses, and fetal crown-rump length as well as cauda length, and caused an increase in the number of both dead fetuses and resorptions...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28882894/zinc-oxide-nanoparticles-provide-anti-cholera-activity-by-disrupting-the-interaction-of-cholera-toxin-with-the-human-gm1-receptor
#20
Shamila Sarwar, Asif Ali, Mahadeb Pal, Pinak Chakrabarti
Vibrio cholerae causes cholera and is the leading cause of diarrhea in the developing countries, highlighting the need for the development of new treatment strategies to combat this disease agent. While exploring the possibility of using zinc oxide (ZnO) nanoparticles (NPs) in cholera treatment, we previously found that ZnO NPs reduce fluid accumulation in mouse ileum induced by the cholera toxin (CT) protein. To uncover the mechanism of action of ZnO NPs on CT activity, here we used classical (O395) and El Tor (C6706) V...
September 7, 2017: Journal of Biological Chemistry
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