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Bharathi Avula, Amar G Chittiboyina, Satyanarayanaraju Sagi, Yan-Hong Wang, Mei Wang, Ikhlas A Khan, Pieter A Cohen
Vinpocetine and picamilon are drugs prescribed in many countries to treat a variety of cerebrovascular disorders. In the United States, vinpocetine and picamilon have never been approved by the US Food and Drug Administration, but they are both available for sale directly to consumers as dietary supplements. We designed our study to determine the accuracy of supplement labels with regard to the presence and quantity of vinpocetine and picamilon. A validated ultra-high performance liquid chromatography-photodiode-array method was developed for the quantification of vinpocetine and picamilon...
March 2016: Drug Testing and Analysis
E L Vishnevskiĭ, O B Loran, N B Guseva, S S Nikitin
During examination of 165 children aged 5 to 15 years (primarily identified during planned monitoring in Petrozavodsk children's institutions) with dysfunctional urination and encopresis without organic lesion of the central nervous system, autonomic dysfunction syndrome (ADS) was revealed. According to the results of urological examination, which was supplemented with the registration of spontaneous voiding rate and counting the radial pulse, overactive bladder syndrome and insufficient relaxation of the pelvic floor muscles during urination and defecation were detected; relationship between the number of heart rate (as a marker of sympathetic nervous system activity) and the effective volume was identified...
November 2013: Urologii︠a︡
V V Danilov, T I Danilova, V V Danilov, V V Danilov
17 patients (mean age, 61 +/- 1.7 years) with an benign prostate hyperplasia (BPH) and urination disorders were under observation. After examination by ultrasound, urodynamic and laboratory studies, patients received conservative combined therapy, including alpha1-adrenoblocker silodosin, L-carnitine, B vitamins and picamilon. As a result of the 4,5-month treatment, most of the symptoms were eliminated as evidenced by the decrease in IPSS score from 17 to 3; urodynamic parameters have improved that was recorded by the home uroflowmetry...
September 2013: Urologii︠a︡
E A Egorov, A A Gvetadze, N G Davydova
Purpose was to study efficiency and safety of mexidol in combined therapy in patients with primary open-angle glaucoma (POAG). 94 patients (185 eyes) at the age of 18-75 years old with POAG I-III stages were divided into 3 groups: 50 patients received combined therapy of mexidol 100 mg and picamilon 150 mg, 22 patients received combined therapy of mexidol 300 mg and picamilon 150 mg, 22 patients received only picamilon 150 mg. All medicine was administered qd during 14 or 21 days. Examination included standard ophthalmologic methods, perimetry, electroretinography, retinal and optic nerve heard arterial blood flow...
March 2013: Vestnik Oftalmologii
E A Egorov, A A Gvetadze, E P Vinogradova
The results of comparative study of efficacy and safety of vision correcting system "Focus" and Picamilon in patients with dry form of age macular degeneration are presented. 60 patients were enrolled into the study, follow-up was 3 months. Routine examination revealed positive impact of "Focus" on dynamics of main visual functions (visual acuity and field). In terms of impact on dynamics of main visual functions "Focus" is comparable with Picamilon, though it is better tolerated. Intake of vision correcting system "Focus" promotes visual functions improvement and prevents progressing of retinal degenerations...
January 2012: Vestnik Oftalmologii
V P Akopian, L S Balian, N A Zakarian
The influence of picamilon and piracetam on the quantitative changes in the central GABA(A) macromolecular receptor complexes in the rat brain has been investigated under the experimental conditions of hypokinesia. It was found that the injection of these nootropes under the conditions of 7-day hypokinesia and 4-day recovery period did not show visible changes in the amount of active GABA(A) receptors. However, the injection of picamilon under the conditions of 15-day hypokinesia and 8-day recovery period showed a tendency to restoration of the number of active GABA(A) receptors...
July 2010: Eksperimental'naia i Klinicheskaia Farmakologiia
Wenqi Cui, Xiaoyan Chen, Yan Zhan, Zhenzhong Zhang, Yifan Zhang, Dafang Zhong
A rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of picamilon concentration in human plasma. Picamilon was extracted from human plasma by protein precipitation. High performance liquid chromatography separation was performed on a Venusil ASB C(18) column with a mobile phase consisting of methanol -10mM ammonium acetate-formic acid (55:45:01, v/v/v) at a flow rate of 0.65ml/min. Acquisition of mass spectrometric data was performed in selected reaction monitoring mode, using the transitions of m/z 209...
May 1, 2010: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
V A Likhodeev, A A Spasov, I B Isupov, V B Mandrikov
The administration of aminalon (0.25 g), fenibut (0.25 g) and picamilon (0.10 g) during 4 weeks as a means of recovery for swimmers with disadaptation syndrome helped to optimize the biochemical status and cerebral circulation 20-min after warm-up. The reaction to the warm-up load under test conditions was characterized by increasing total blood filling of the brain and difficulty of venous outflow. Under the action of drugs, a decrease in blood filling of the brain and increase in venous blood outflow from the cerebral basin was observed 20 min after load in all test groups (except the hypokinetic group taking picamilon)...
July 2009: Eksperimental'naia i Klinicheskaia Farmakologiia
V P Akopian, L S Balian, N A Avetisian
The influence of a 15-day hypokinesia on the development of anxiety-depression state and quantitative changes in the central GABA-A macromolecular receptor complexes in the rat brain has been investigated under conditions of the despair (forced swim) test. Simultaneously, the effects of well-known nootropic drugs picamilon and piracetam on the dynamics of state parameters in the experimental animals have been evaluated. It was found that hypokinesia led to the development of anxiety and depression accompanied by reduction in the amount of active GABA-A receptors...
March 2006: Eksperimental'naia i Klinicheskaia Farmakologiia
I V Kazanskaia, I S Mudraia, V I Kirpatovskiĭ, Z R Sabirzianova, I L Babanin
A total of 43 infants under 3 years of age with organic, functional and reflux obstructive megaureter were studied. The function of the upper urinary tract was examined with dynamic pyeloureterosonography with diuretic load. Contractility of isolated fragments of megaureters and possibility of its pharmacological regulation were studied in patients after surgery in vitro. Different urodynamic variants of the response of refluxing and obstructive megaureters and those with functional obstruction on stimulation of diuresis were established at dynamic pyeloureterosonography with diuretic load...
May 2005: Urologii︠a︡
I V Silkina, T C Gan'shina, S B Seredin, R S Mirzoian
The role of GABAergic mechanisms in realization of the effects of afobazole and picamilon on the cerebral circulation was studied in rats. It is found that the cerebrovascular effect of afobazole significantly decreases on the background of the GABA receptor antagonists bicuculline and picrotoxin. This is evidence of an important role of the GABA system in the its cerebrovascular and neuroprotective activity of afobazole. The results of experiments with picamilon showed that the cerebrovascular effect of this drug is not affected by receptor blocking with bicucullin...
January 2005: Eksperimental'naia i Klinicheskaia Farmakologiia
L I Bugaeva, A A Spasov, V E Verovskiĭ, I N Iezhitsa
A comparative acute toxicity test of the nootropic drugs piracetam and picamilon was performed on rats. The study was based on the principles of integral evaluation of the drug effect upon the functional and behavioral state of animals. It was found that the conventional therapeutic index does not coincide with the actual therapeutic activity range. Piracetam and picamilon, while exhibiting significantly different toxicity, are characterized by approximately equal ranges of the therapeutic activity.
July 2003: Eksperimental'naia i Klinicheskaia Farmakologiia
R S Mirzoian
The paper is devoted to the role of GABA system in the pharmacotherapy of ischemic brain injuries. In an analysis of the neuroprotector activity of GABA-mimetics, both their involvement in the maintenance of a balance between exciting and inhibiting processes and participation of the GABAergic mechanisms in regulation of the cerebrovascular tone are considered because proper blood supply is an important factor in the successful therapy of patients with ischemic brain injuries. Data available in the literature and the results of original investigations are summarized to assess the cerebrovascular and neuroprotector properties of GABA, as well as agonists and modulators of GABA receptors (muscimol, picamilon, phelbamate, clomethiazole, etc...
March 2003: Eksperimental'naia i Klinicheskaia Farmakologiia
Z A Rozanova
Absorption by the bovine retina of physiological concentration of PLP-GABA increase clearing 2-32 minutes of incubation in difference of GABA and its non metabolic preparations, which store up as much as possible in first minutes: picamilon > PLP-GABA > GABA > panthogam > biotinil-GABA. Kinetics of transport of GABA and its preparations into retina has a complex character. By the growth of concentration from 33 mM to 528 mM, it is linear for picamilion, showing diffusion, and not linear for GABA, PLP-GABA and panthogam, showing differently systems of its transport...
2001: Fiziolohichnyĭ Zhurnal
S N Basinskiĭ, V N Krasnogorskaia, Iu A Lenis
Picamilon was used in the treatment of 48 patients with central chorioretinal dystrophies. In group 1 (34 eyes) the drug was delivered to the posterior pole of the eye through an infusion collagen system, which was followed by He-Ne laser exposure. In group 2 (46 eyes) the patients were given picamilon tablets. The following examinations were carried out in all patients before and immediately after treatment: evaluation of visual acuity, borders of peripheral visual field, critical frequency of fusion of flashes, visocontrastometry, electroretinography with consideration for pathological changes in the retina, rheography, direct and indirect ophthalmoscopy...
March 2001: Vestnik Oftalmologii
I D Sapegin
Electric impedance measurements on awake rabbits with electrodes implanted into cortex, thalamus, and hypothalamus showed that modeling of the noise and general (wide-band) vibration, as well as their combination with sea-sickness action, leads to disturbances in the aqueous-electrolyte balance in brain. This is manifested by extracellular and (less pronounced) intracellular edema development. Picamilon administration (10 mg/kg, i.v.) completely prevented development of the vibration-induced intracellular edema and markedly reduced the development of damage in all other cases studied...
September 2000: Eksperimental'naia i Klinicheskaia Farmakologiia
V E Pogorelyĭ, M D Gaevyĭ
Acute experiments were conducted on rats under nembutal anesthesia to compare the efficacy of emoxipin with that of lithium oxybutyrate and picamilon in the postischemic period after preventive and therapeutic injections in various doses. Emoxipin proved to be most effective in prevention of postischemic non-restoration of the flow of blood in the brain and in preservation of the autoregulation responses of the cerebral vessels. The possible mechanisms of the effect of the drug are discussed.
November 1999: Eksperimental'naia i Klinicheskaia Farmakologiia
T M Kuchmerovskaia, P K Parkhomets, G V Donchenko, I G Obrosova, A P Klimenko, N A Kuchmerovskiĭ, L V Pakirbaeva, A S Efimov
Streptosotocin-induced diabetes in rats is accompanied by the development of diabetic complications such as neuropathies. [2-14C]serotonin and [U-14C]GABA release from the neurotransmitter pre-loaded synaptosomes showed significant elevation. Aldose reductase inhibitors (AL-1576, sorbinil) administration leads to partial restoration of serotonin and GABA release, while picamilon restored only GABA release. It was shown that Na+,K(+)-ATPase activities decreased in synaptosomes, synaptic membranes and sciatic nerve of diabetic rats compared to control...
November 1998: Voprosy Medit︠s︡inskoĭ Khimii
V E Novikov, L A Kovaleva
A craniocerebral trauma was modelled in experiments on one-month-old rats. Oxidative phosphorylation in the brain mitochondria was studied by polarography 1, 4, 7 days and 4 weeks after the trauma. In the posttraumatic period the animals received piracetam (1 g/kg), picamilon (500 mg/kg), pyriditol (100 mg/kg), pantogam (160 mg/kg), ACTH (5-10) (0.1 mg/kg), nooglutyl (25 mg/kg), and GVS (0.5 mg/kg). It was found that piracetam, picamilon, and nooglutyl have a protective effect on the function of the brain mitochondria during the course of a craniocerebral trauma...
March 1998: Eksperimental'naia i Klinicheskaia Farmakologiia
V E Novikov, L A Kovaleva
An open craniocerebral trauma was simulated in rat experiments. Oxidative phosphorylation in the brain mitochondria was studied by polygraphy 24 h after the trauma. It was found that trauma to the brain leads to inhibition of respiration in mitochondria in various metabolic states. Nooglutil in a dose of 50 mg/kg prevents these changes. Nooglutil is more effective than picamilon (500 mg/kg) and piriditol (100 mg/kg).
January 1997: Eksperimental'naia i Klinicheskaia Farmakologiia
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