John D FitzGerald, Nicola Dalbeth, Ted Mikuls, Romina Brignardello-Petersen, Gordon Guyatt, Aryeh M Abeles, Allan C Gelber, Leslie R Harrold, Dinesh Khanna, Charles King, Gerald Levy, Caryn Libbey, David Mount, Michael H Pillinger, Ann Rosenthal, Jasvinder A Singh, James Edward Sims, Benjamin J Smith, Neil S Wenger, Sangmee Sharon Bae, Abhijeet Danve, Puja P Khanna, Seoyoung C Kim, Aleksander Lenert, Samuel Poon, Anila Qasim, Shiv T Sehra, Tarun Sudhir Kumar Sharma, Michael Toprover, Marat Turgunbaev, Linan Zeng, Mary Ann Zhang, Amy S Turner, Tuhina Neogi
OBJECTIVE: To provide guidance for the management of gout, including indications for and optimal use of urate-lowering therapy (ULT), treatment of gout flares, and lifestyle and other medication recommendations. METHODS: Fifty-seven population, intervention, comparator, and outcomes questions were developed, followed by a systematic literature review, including network meta-analyses with ratings of the available evidence according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology, and patient input...
June 2020: Arthritis Care & Research