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https://www.readbyqxmd.com/read/29456952/clinicopathological-significance-of-tumor-lymphatic-vessel-density-in-head-and-neck-squamous-cell-carcinoma
#1
Padam Parmar, Nisha Marwah, Sanjeev Parshad, Taruna Yadav, Ashima Batra, Rajeev Sen
Various studies have demonstrated that the lymphatic system is the additional route for solid tumor metastasis. Lymph nodes metastasis in Head and neck squamous cell carcinoma (HNSCC) is a major prognostic indicator for disease progression and a guide for therapeutic strategies. We conducted a study to compare intratumoral (IT) and peritumoral (PT) lymphatic vessel density (LVD) in HNSCC using lymphatic marker D2-40 and its correlation with lymph node metastasis, histological grading and other clinicopathological parameters...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29454311/radiotherapy-related-skin-toxicity-rarest-01-mepitel%C3%A2-film-versus-standard-care-in-patients-with-locally-advanced-head-and-neck-cancer
#2
Carlos Narvaez, Claudia Doemer, Christian Idel, Cornelia Setter, Denise Olbrich, Zaza Ujmajuridze, Jesper Hansen Carl, Dirk Rades
BACKGROUND: The aim of the present trial is to investigate a new option of skin protection in order to reduce the rate of grade ≥ 2 skin toxicity in patients receiving radiotherapy alone or radiochemotherapy for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN). METHODS / DESIGN: This is a randomized, active-controlled, parallel-group multi-center trial that compares the following treatments of radiation dermatitis in patients with head-and-neck cancer: Mepitel® Film (Arm A) vs...
February 17, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29452770/single-arm-phase-2-trial-of-elective-nodal-dose-reduction-for-patients-with-locoregionally-advanced-squamous-cell-carcinoma-of-the-head-and-neck
#3
Patrick D Maguire, Charles R Neal, Stuart M Hardy, Andrew M Schreiber
PURPOSE: To evaluate a novel chemoradiation therapy (CRT) regimen for patients with squamous cell carcinoma of the head and neck (SCCHN) incorporating a lower intensity modulated radiation therapy dose to electively treated neck lymph nodes than is currently standard. METHODS AND MATERIALS: Eligible patients had locally advanced SCCHN of the oral cavity, oropharynx, larynx, or hypopharynx. The 7-week CRT course consisted of weekly cisplatin at 35 mg/m 2 concurrently with sequential-boost intensity modulated radiation therapy: 36 Gy to high- and low-risk planning target volumes followed by a sequential boost to the high-risk planning target volume to 70 Gy...
December 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29445071/a-case-report-of-thyroid-metastasis-from-p16-positive-oropharyngeal-squamous-cell-carcinoma
#4
Masao Takenobu, Sueyoshi Moritani, Kana Yoshioka, Tsuyoshi Morisaki, Hiroya Kitano
Thyroid metastasis from head and neck squamous cell carcinoma (SCC) is a very rare form of rarely observed metastatic thyroid tumor. We herein report a case of thyroid metastasis from oropharyngeal SCC (OSCC). The patient was a 68-year-old male diagnosed with p16-positive tonsillar OSCC on the right side with multiple lymph node metastases and a thyroid mass, which was determined as metastatic p16-positive OSCC by immunohistochemistry of specimens collected by fine-needle aspiration cytology (FNAC). He received one cycle of induction chemotherapy followed by concurrent chemoradiotherapy...
February 15, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29438531/characteristics-of-follicular-variant-papillary-thyroid-carcinoma-in-a-pediatric-cohort
#5
S L Samuels, L F Surrey, C P Hawkes, M Amberge, S Mostoufi-Moab, J E Langer, N S Adzick, K Kazahaya, T Bhatti, Z Baloch, V A LiVolsi, A J Bauer
Context: In adults, non-invasive follicular variant papillary thyroid carcinoma (FVPTC) is considered low risk for metastasis and persistent/recurrent disease. Objective: The goal of this study was to assess the clinical, sonographic, and histopathological features of FVPTC in a pediatric cohort. Design: A retrospective review of subjects < 19 years of age with papillary thyroid carcinoma (PTC) who underwent thyroidectomy between January 2010 and July 2015...
February 8, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29434944/microrna-196a-5p-is-a-potential-prognostic-marker-of-delayed-lymph-node-metastasis-in-early-stage-tongue-squamous-cell-carcinoma
#6
Tessho Maruyama, Kazuhide Nishihara, Masato Umikawa, Akira Arasaki, Toshiyuki Nakasone, Fumikazu Nimura, Akira Matayoshi, Kimiko Takei, Saori Nakachi, Ken-Ichi Kariya, Naoki Yoshimi
MicroRNAs (miRs) are expected to serve as prognostic tools for cancer. However, many miRs have been reported as prognostic markers of recurrence or metastasis in oral squamous cell carcinoma patients. We aimed to determine the prognostic markers in early-stage tongue squamous cell carcinoma (TSCC). Based on previous studies, we hypothesized that miR-10a, 10b, 196a-5p, 196a-3p, and 196b were prognostic markers and we retrospectively performed miR expression analyses using formalin-fixed paraffin-embedded sections of surgical specimens...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29432281/lymph-node-ratio-as-a-prognostic-factor-in-melanoma-results-from-european-organization-for-research-and-treatment-of-cancer-18871-18952-and-18991-studies
#7
Alessandro A Testori, Stefan Suciu, Alexander C J van Akkooi, Mariano Suppa, Alexander M M Eggermont, Esther de Vries, Arjen Joosse
The aim of this study was to assess the prognostic importance of lymph node ratio (LNR) in stage III melanoma after complete lymph nodal dissections. From European Organization for Research and Treatment of Cancer randomized trials 18871, 18952, and 18991, 2358 patients had full information on positive and examined lymph nodes (LNs) and were included. Cox proportional hazards models stratified by trial were used to assess the prognostic impact of LNR adjusted for confounders on melanoma-specific survival. Optimal cutoff values for LNR were calculated for each LN dissection site (axillary, inguinal, and neck)...
February 9, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29431057/evolution-in-the-management-of-thyroid-cancer-an-observational-study-in-two-referral-centres-in-belgium
#8
Bernard Peene, Annick Van den Bruel, Carolien Moyson, Brigitte Decallonne
Objective Thyroid cancer incidence is increasing. The rise is most pronounced for microcancers (≤10 mm, T1a). In 2006, landmark European and American guidelines for the management of thyroid cancer were published. We studied thyroid cancer characteristics and initial management before and after 2006. Methods We conducted a retrospective observational study of non-medullary thyroid cancer patients that underwent thyroidectomy in two Belgian referral centres comparing pre-, per- and post-operative management in a cohort before and after 2006...
February 12, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29429223/-neck-lymphatic-metastasis-surgical-methods-and-prognosis-in-early-tongue-squamous-cell-carcinoma
#9
L S Wang, F T Zhou, C B Han, X P He, Z X Zhang
Objective: To investigate the different pattern of neck lymph node metastasis, the choice of surgical methods and prognosis in early tongue squamous cell carcinoma. Methods: A total of 157 patients with early oral tongue squamous cell carcinoma were included in this study. Statistical analysis was performed to identify the pattern of lymph node metastasis, to determine the best surgical procedure and to analyze the prognosis. Results: The occurrence of cervical lymph node metastasis rate was 31%(48/157). Neck lymphatic metastasis was significantly related to tumor size (P=0...
February 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29429177/-planned-neck-dissection-in-the-treatment-of-locally-advanced-head-and-neck-squamous-cell-carcinoma
#10
L Jiang, J L Lou, K J Wang, M Y Fang, Z F Fu
Objective: To investigate the value of planned neck dissection combined with induction chemotherapy and concurrent chemoradiotherapy in regional control and the outcome of locally advanced head and neck squamous cell carcinoma. Methods: A prospective randomized controlled study totally enrolled sixty-four patients of head and neck squamous cell carcinomas(include oropharynx, hypopharynx, and larynx) in stages Ⅳa-Ⅳb with lymph node metastase was were N2-N3. All patients firstly received 2-3 cycles of induction chemotherapy(ICT), then divided into two groups randomly, according to the efficacy of ICT...
February 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29428971/emergence-of-anti-mitochondrial-m2-antibody-in-patient-with-angioimmunoblastic-t-cell-lymphoma
#11
Shun-Ichi Wakabayashi, Takefumi Kimura, Naoki Tanaka, Satoru Joshita, Kazuhito Kawata, Takeji Umemura, Yuki Hiroshima, Hiromitsu Mori, Hikaru Kobayashi, Shuichi Wada, Eiji Tanaka
A 68-year-old woman was referred to our hospital due to fever and rash on the neck and extremities. Laboratory findings revealed hepatic dysfunction and positivity for anti-mitochondrial M2 antibody (AMA-M2). Hepatosplenomegaly and systemic lymphadenopathy were detected by enhanced computed tomography. One week after her first visit, hypoxemia, ascites, and Coomb test-positive autoimmune hemolytic anemia had newly appeared in addition to worsened fever, hepatosplenomegaly, and lymphadenopathy. Results of axillary lymph node, skin, and bone-marrow biopsies led to the diagnosis of angioimmunoblastic T-cell lymphoma (AITL), for which CEPP therapy (cyclophosphamide, etoposide, procarbazine, and prednisolone) was initiated...
February 10, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29423108/cancer-immunogenomic-approach-to-neoantigen-discovery-in-a-checkpoint-blockade-responsive-murine-model-of-oral-cavity-squamous-cell-carcinoma
#12
Paul Zolkind, Dariusz Przybylski, Nemanja Marjanovic, Lan Nguyen, Tianxiang Lin, Tanner Johanns, Anton Alexandrov, Liye Zhou, Clint T Allen, Alexander P Miceli, Robert D Schreiber, Maxim Artyomov, Gavin P Dunn, Ravindra Uppaluri
Head and neck squamous cell carcinomas (HNSCC) are an ideal immunotherapy target due to their high mutation burden and frequent infiltration with lymphocytes. Preclinical models to investigate targeted and combination therapies as well as defining biomarkers to guide treatment represent an important need in the field. Immunogenomics approaches have illuminated the role of mutation-derived tumor neoantigens as potential biomarkers of response to checkpoint blockade as well as representing therapeutic vaccines...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29419687/synchronous-papillary-thyroid-cancer-and-non-hodgkin-lymphoma-case-report
#13
Georgi I Popivanov, Pavel Bochev, Radka Hristoskova, Ventsislav M Mutafchiyski, Mihail Tabakov, Anthony Philipov, Roberto Cirocchi
RATIONALE: Differentiated thyroid cancer is the most common endocrine malignancy with concomitant hematological malignancy in 7%. PATIENT CONCERNS: We present a case of a synchronous papillary thyroid cancer and a follicular variant of non-Hodgkin lymphoma and discuss the possible diagnostic and treatment dilemmas. DIAGNOSIS: A 48-year-old female was reffered to our hospital with diagnosis "thyroid cancer". Due to a history compatable of synchronous lymphoproliferative disease we performed a computed tomography, which revealed multiple enlarged lymph nodes in the neck, mediastinum, axilla and abdomen...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29417404/solitary-pulmonary-lesion-in-patients-with-history-of-malignancy-primary-lung-cancer-or-metastatic-cancer
#14
Ke Jin, Kexi Wang, Huizhong Zhang, Yuejiang Pan, Dexiong Cao, Minghui Wang, Ju Chen, Duoguang Wu, Boshen Chen, Xuan Xie
BACKGROUND: Defining the status of solitary pulmonary lesion (SPL) in patients with history of malignancy is important because primary lung cancer (PLC) or intrapulmonary metastasis might indicate different surgical strategies. The aim of this study is to identify factors related to the status of these lesions and construct a clinical model to estimate the pretest probability of PLC. METHODS: From January 2005 to January 2016, 104 patients with previous malignancy and suitable for surgery were retrospectively studied...
February 7, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29414634/anaplastic-thyroid-carcinoma-in-denmark-1996-2012-a-national-prospective-study-of-219-patients
#15
Gitte Bjørn Hvilsom, Stefano Christian Londero, Christoffer Holst Hahn, Sten Schytte, Henrik Baymler Pedersen, Peer Christiansen, Katalin Kiss, Stine Rosenkilde Larsen, Marie Louise Jespersen, Giedrius Lelkaitis, Christian Godballe
BACKGROUND: Anaplastic thyroid carcinoma (ATC) is the least common but most malignant thyroid cancer. We aimed to examine the characteristics as well as evaluate the incidence, prognostic factors, and if introduction of a fast track cancer program might influence survival in a cohort of ATC patients. METHODS: A cohort study based on prospective data from the national Danish thyroid cancer database DATHYRCA and the national Danish Pathology Register including 219 patients diagnosed from 1996 to 2012, whom were followed until death or through September 2014...
January 31, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29412383/metastatic-lymph-node-characteristics-as-predictors-of-recurrence-persistence-in-the-neck-and-distant-metastases-in-differentiated-thyroid-cancer
#16
Mayara Peres Barbosa, Denise Momesso, Daniel Alves Bulzico, Terence Farias, Fernando Dias, Roberto Araújo Lima, Rossana Corbo, Mario Vaisman, Fernanda Vaisman
OBJECTIVE: The aim of this study was to evaluate the association between this characteristic and outcomes in patients with lymph node metastasis in a Brazilian cohort. SUBJECTS AND METHODS: This study examined a retrospective cohort of adult patients diagnosed with differentiated thyroid cancer and lymph node metastases from 1998 to 2015 in two referral centers. Number, location, size and extranodal extension (ENE) of metastatic lymph nodes were assessed and correlated with response to initial therapy...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29408964/a-homozygous-ret-k666n-genotype-with-an-men2a-phenotype
#17
Tania Jaber, Samuel M Hyde, Gilbert J Cote, Elizabeth G Grubbs, Wesley H Giles, Cathy A Stevens, Ramona Dadu
Context: Germline RET K666N mutation has been described as a pathogenic mutation with low disease penetrance for medullary thyroid cancer (MTC) without other features of MEN2A. We describe a patient with homozygous RET K666N mutation with MTC and bilateral pheochromocytoma (PHEO). Case Description: A 59-year-old female was diagnosed with MTC after biopsy of two thyroid nodules. Coincident biochemical and radiologic testing was suspicious for bilateral PHEO, confirmed after bilateral adrenalectomy...
February 2, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29402183/temporal-trends-in-the-presentation-treatment-and-outcome-of-medullary-thyroid-carcinoma-an-israeli-multicenter-study
#18
Dania Hirsch, Orit Twito, Sigal Levy, Gideon Bachar, Eyal Robenshtok, David Gross, Haggi Mazeh, Carlos Benbassat, Simona Grozinsky-Glasberg
BACKGROUND: The widespread use of neck sonography in recent years has led to a dramatic increase in the detection of thyroid cancer, accompanied by changes in the clinicopathological features of the disease. However, small papillary carcinomas account for the bulk of this increase, while little is known about temporal changes in medullary thyroid carcinoma (MTC). The aim of this study was to evaluate trends in the presentation, treatment, and outcome of MTC. METHODS: Patients treated for MTC at four medical centers in Israel were divided into three groups by year of diagnosis: 1981-1995 (period A), 1996-2005 (period B), and 2006-2016 (period C)...
February 5, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29399393/pd-1-blockade-reverses-adaptive-immune-resistance-induced-by-high-dose-hypofractionated-but-not-low-dose-daily-fractionated-radiation
#19
Megan Morisada, Paul E Clavijo, Ellen Moore, Lillian Sun, Michael Chamberlin, Carter Van Waes, James W Hodge, James B Mitchell, Jay Friedman, Clint T Allen
Preclinical evidence suggests that high-dose hypofractionated ionizing radiation (IR) can enhance anti-tumor immunity and result in significant tumor control when combined with immune checkpoint blockade (ICB). However, low-dose daily fractioned IR used for many tumor types including head and neck squamous cell carcinoma results in lymphopenia and may be immunosuppressive. We compared immune correlates, primary tumor and abscopal tumor control rates following the addition of PD-1 mAb to either high-dose hypofractioned (8Gyx2) or low-dose daily fractionated (2Gyx10) IR in syngeneic models of cancer...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29399178/g-csf-producing-oral-carcinoma-with-diffuse-uptake-of-fdg-in-the-bone-marrow-a-case-report
#20
Takeshi Kuroshima, Mayumi Wada, Takehiko Sato, Masashi Takano, Shujiroh Makino
A 78-year-old male patient was referred to the Department of Oral Surgery, Hokuto Hospital (Obihiro, Japan) for painless swelling on the left neck and tongue. Histopathological examination of a biopsy specimen resulted in a diagnosis of squamous cell carcinoma of the tongue. Imaging examinations revealed cervical lymph node metastases on both sides, along with diffuse uptake of 18F-fluorodeoxyglucose (FDG) in the bone marrow of the spine and pelvis. Hematologic tests revealed an increased white blood cell (WBC) count and serum concentrations of granulocyte colony stimulating factor (G-CSF)...
January 2018: Oncology Letters
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