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https://www.readbyqxmd.com/read/28217017/prognostic-significance-of-standardized-uptake-value-on-18-fluorine-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-patients-with-nasopharyngeal-carcinoma
#1
Şeyda Türkölmez, Sabire Yılmaz Aksoy, Elif Özdemir, Zuhal Kandemir, Nilüfer Yıldırım, Atiye Yılmaz Özsavran, Mehmet Faik Çetindağ, Kenan Köse
The aim of this study was to investigate the prognostic significance of standardized uptake value (SUV) on 18 fluorine-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) in patients with nasopharyngeal carcinoma (NPC). Thirty-four patients who have histologically proven NPC and underwent (18)F-FDG PET/CT were included in this study. After (18)F-FDG PET/CT, all the patients received radiation therapy and 32 of them received concomitant weekly chemotherapy. The maximum SUV (SUVmax) at the primary tumor and the SUVmaxof the highest neck nodes were determined...
January 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28216937/renal-cell-carcinoma-atypical-metastasis-to-inguinal-lymph-nodes
#2
Qamar Saeed Chaudhry, Tanweer Ahmed Naveed Bhatty, Ziauddin Khan, Elsawi Medani Osman
Renal cell carcinoma (RCC) is a common tumor of the urinary tract. It is known to have variable presentations due to the extremely vascular nature of the organ. RCC are known to metastasize to lungs, bone, and brain commonly but atypical metastasis to various sites are reported in literature but as very rare pathology. We report a case of a 60-year-old female who presented with multiple inguinal and axillary lymph node enlargements which on excision biopsy showed metastatic RCC. RCC can present with synchronous metastatic deposits in the various organs...
January 2017: Urology Annals
https://www.readbyqxmd.com/read/28216228/elective-neck-dissection-in-unilateral-carcinomas-of-the-tongue-unilateral-versus-bilateral-approach
#3
Christopher-Philipp Nobis, Sven Otto, Tamara Grigorieva, Mohamed Alnaqbi, Matthias Troeltzsch, Jakob Schöpe, Stefan Wagenpfeil, Michael Ehrenfeld, Klaus-Dietrich Wolff, Marco Rainer Kesting
PURPOSE: Elective neck dissection (END) is a common primary treatment strategy for oral tongue squamous cell carcinoma (OTSCC), although uncertainty remains regarding the necessary extent of END for strictly unilateral early stage OTSCC. The authors evaluated two END variations, unilateral and bilateral, to determine the optimal extent. MATERIALS AND METHODS: A retrospective cohort study was performed on patient data from two departments of oral and maxillofacial surgery...
January 25, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28215944/cd44-cancer-cell-induced-metastasis-a-feasible-neck-metastasis-model
#4
Tian-Fu Wu, Lei Chen, Lin-Lin Bu, Jie Gao, Wen-Feng Zhang, Jun Jia
Neck metastasis of oral squamous cell carcinoma (OSCC) indicates a poor prognosis. Few neck metastasis models are currently available for drug trials and clinical research on OSCC. This study constructed a feasible animal model of neck metastasis by using CD44+ stem cell-like cancer cells. Real-time PCR was used to determine the expression levels of several reported cancer stem cell (CSC) markers, including CD44, CD133, ALDH1 and OCT4, in three OSCC cell lines. Magnetic sorting and DiO/DiD labelling were used to isolate subpopulations of cells and monitor cancer cell migration...
February 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28214213/the-relationship-between-brafv600e-nf-%C3%AE%C2%BAb-and-tgab-expression-in-papillary-thyroid-carcinoma
#5
Wei Li, Hui Ming, Danyang Sun, Wei Li, Dan Wang, Guizhi Zhang, Jian Tan
PURPOSE: The aim of this study was to investigate the potential link between thyroglobulin antibody (TgAb) titers and papillary thyroid carcinoma (PTC) aggressiveness. MATERIALS AND METHODS: This retrospective study included 122 patients who had undergone total thyroidectomy and neck central area lymph dissection followed by radioactive iodine (RAI) ablation for PTC between July 2012 and July 2014. The parameters included clinical characteristics of PTC, TgAb levels and tumor histopathological characteristics...
January 12, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28212555/construction-of-a-pathological-risk-model-of-occult-lymph-node-metastases-for-prognostication-by-semi-automated-image-analysis-of-tumor-budding-in-early-stage-oral-squamous-cell-carcinoma
#6
Nicklas Juel Pedersen, David Hebbelstrup Jensen, Giedrius Lelkaitis, Katalin Kiss, Birgitte Charabi, Lena Specht, Christian von Buchwald
It is challenging to identify at diagnosis those patients with early oral squamous cell carcinoma (OSCC), who have a poor prognosis and those that have a high risk of harboring occult lymph node metastases. The aim of this study was to develop a standardized and objective digital scoring method to evaluate the predictive value of tumor budding. We developed a semi-automated image-analysis algorithm, Digital Tumor Bud Count (DTBC), to evaluate tumor budding. The algorithm was tested in 222 consecutive patients with early-stage OSCC and major endpoints were overall (OS) and progression free survival (PFS)...
February 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28209383/expression-pattern-of-heat-shock-protein-90-in-patients-with-oral-squamous-cell-carcinoma-in-northern-taiwan
#7
W-C Chang, P-T Tsai, C-K Lin, Y-S Shieh, Y-W Chen
Heat shock protein 90 (HSP90), which is expressed in cancer cells, profoundly affects progression, invasion, and metastasis. However, to our knowledge, in East Asia, the correlation between the expression of HSP90 and clinicopathological variables has seldom been discussed. We therefore investigated this and its prognostic value in 36 patients newly diagnosed with oral squamous cell carcinoma (SCC) in northern Taiwan. Samples of tumour and normal samples from the patients were compared immunohistochemically...
February 13, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28205384/cribriform-adenocarcinoma-of-the-minor-salivary-gland-arising-in-the-tonsil-with-metastasis-to-a-cervical-lymph-node-a-case-report-with-description-of-fine-needle-aspiration-cytology
#8
Alexa Pagano, Katie Dennis
Cribriform adenocarcinoma of minor salivary gland (CAMSG) is a rare tumor of the head and neck. We report a case of a 70-year-old female who presented with a 4-5-month history of a left neck mass. CT scan of the neck showed a left neck mass just inferior to the angle of the mandible and left tonsillar prominence. Fine-needle aspiration (FNA) of the neck mass showed epithelial groups with focal cribriform architecture. The cells had round to oval nuclei and fine chromatin. The background contained scattered lymphocytes...
February 16, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28204971/the-presence-of-cancerous-nodules-in-lymph-nodes-is-a-novel-indicator-of-distant-metastasis-and-poor-survival-in-patients-with-papillary-thyroid-carcinoma
#9
Ling Chen, Youzhi Zhu, Ke Zheng, Huihao Zhang, Hongkun Guo, Li Zhang, Kunlin Wu, Lingjun Kong, Weihong Ruan, Jianying Hu, Xin Zhang, Xiangjin Chen
PURPOSE: Several characteristics of lymph node metastasis (LNM) as predictors of the risk of recurrence or death were examined in patients with papillary thyroid carcinoma (PTC). The presence of cancerous nodules as a characteristic of LNMs in PTC has not yet been reported. The objective of this study was to evaluate the use of the cancerous nodules in the lymph node (CNLN) to determine the risk of distant metastasis and survival in patients with PTC. METHODS: This retrospective observational cohort study enrolled 1408 patients with pathologically confirmed PTC without initial distant metastasis who underwent thyroidectomy and neck dissection...
February 15, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28202188/rate-of-regional-nodal-metastases-of-cutaneous-squamous-cell-carcinoma-in-the-immunosuppressed-patient
#10
Eamon J McLaughlin, Lauren Miller, Thuzar M Shin, Joseph F Sobanko, Steven B Cannady, Christopher J Miller, Jason G Newman
PURPOSE: Immunosuppressed solid organ transplant recipients (SOTRs) have an increased risk of developing cutaneous squamous cell carcinomas (cSCCs) with metastatic potential. This study sought to determine the rate of regional lymph node involvement in a large cohort of solid organ transplant patients with cutaneous head and neck squamous cell carcinoma. MATERIALS AND METHODS: A retrospective chart review was performed on solid organ transplant patients with head and neck cutaneous squamous cell carcinoma treated at a tertiary academic medical center from 2005 to 2015...
February 4, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28199044/prognostic-markers-in-metastatic-cutaneous-squamous-cell-carcinoma-of-the-head-and-neck
#11
Nir Hirshoren, Julia Danne, Benjamin John Dixon, Matthew Magarey, Stephen Kleid, Angela Webb, Albert Tiong, June Corry, David Gyorki
BACKGROUND: The minority of head and neck cutaneous squamous cell carcinomas (SCC) metastasize to regional lymph nodes. The purpose of this study was to describe the clinical outcomes and prognostic factors for patients with node-positive head and neck cutaneous SCC who underwent lymphadenectomy. METHODS: We conducted a retrospective single center study using the Kaplan-Meier method for the investigation of the overall survival (OS) and locoregional control rates...
February 15, 2017: Head & Neck
https://www.readbyqxmd.com/read/28195253/diagnostic-role-of-detecting-hpv-in-a-fnac-of-metastatic-laterocervical-lymph-node-in-a-case-of-occult-hpv-related-head-and-neck-squamous-cell-carcinoma
#12
A Ginori, F Scaramuzzino, M A G Munezero Butorano, A Barone, A Disanto
Human papillomavirus (HPV)-related head and neck squamous cell carcinomas (HNSCC) are radiosensitive tumors and have a better prognosis than the conventional keratinizing HNSCC. Despite extensive radiographic and clinical evaluation in approximately 3% to 5% of patients who present with cervical lymph node metastases, the primary tumor remains occult. The lack of a clinically identifiable primary tumor usually leads to more aggressive therapy, which can result in higher morbidity. Herein, we report a case of a patient with an occult HPV-related HNSCC, diagnosed detecting HPV in a fine needle aspiration cytology (FNAC) of metastatic laterocervical lymph nodes...
June 2016: Pathologica
https://www.readbyqxmd.com/read/28193302/outcomes-of-transoral-laser-microsurgical-management-of-t1b-stage-glottic-cancer
#13
J A Song, M H Rigby, J Trites, R D Hart, S M Taylor
OBJECTIVE: This study aimed to evaluate the oncological and voice outcomes of transoral laser microsurgery for tumour stage T1b stage glottic cancer patients. METHODS: A prospective cohort study in a tertiary care head and neck cancer centre included tumour-node-metastasis stage T1bN0M0 glottic cancer patients scheduled to undergo transoral laser microsurgery from January 2002 until June 2014. Kaplan-Meier five-year analyses of local control, overall survival, disease-specific survival and laryngeal preservation were performed...
February 14, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28182650/tropomyosin-1-acts-as-a-potential-tumor-suppressor-in-human-oral-squamous-cell-carcinoma
#14
Hao Pan, Liqun Gu, Binjie Liu, Yiping Li, Yuehong Wang, Xinna Bai, Long Li, Baisheng Wang, Qian Peng, Zhigang Yao, Zhangui Tang
It is widely accepted that oral squamous cell carcinoma (OSCC) is a major contributor to the incidence and mortality of neck and head cancer. Tropomyosin-1 (TPM1), which is expressed at a low level, has been considered a prominent tumor-suppressing gene in a variety of solid tumors, although the precise mechanism of the TPM1 gene in OSCC progression remains unknown. We found that TPM1 expression levels decreased in OSCC patients and OSCC cell lines. The overall and cancer-specific survival of patients who exhibited low TPM1 levels were inferior to those of patients who had high TPM1 levels...
2017: PloS One
https://www.readbyqxmd.com/read/28180046/risk-of-delayed-lymph-node-metastasis-in-clinically-n0-esthesioneuroblastoma
#15
Justin G Peacock, William S Harmsen, Michael J Link, Jamie J Van Gompel, Caterina Giannini, Kerry D Olsen, Yolanda I Garces, Michelle A Neben Wittich, Daniel J Ma, Sean S Park, Robert L Foote
Objective To determine both the rate of delayed cervical lymph node metastasis in patients with esthesioneuroblastoma (ENB) and a clinically N0 untreated neck and the effectiveness of salvage treatment. Design Retrospective review. Setting Tertiary academic medical center. Participants All patients from January 1, 1965, to December 31, 2010, who received definitive treatment for ENB. Main Outcome Measures The study involved 52 patients: 27 (52%) patients underwent surgery and adjuvant radiotherapy (SART) to the primary site only and 25 (48%) underwent surgery alone (SA) as treatment of the primary site, without elective neck dissection...
February 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28178144/an-elective-radiation-dose-of-46-gy-is-feasible-in-nasopharyngeal-carcinoma-treated-by-intensity-modulated-radiotherapy-a-long-term-follow-up-result
#16
Tsung-Min Hung, Kang-Hsing Fan, Eric Yen-Chao Chen, Chien-Yu Lin, Chung-Jan Kang, Shiang-Fu Huang, Chun-Ta Liao, Shu-Hang Ng, Hung-Ming Wang, Joseph Tung-Chieh Chang
The purpose of this study is to compare the treatment outcome of different radiation doses of elective neck irradiation (ENI) in nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiotherapy (IMRT).In total, 504 patients with nondisseminated NPC who underwent magnetic resonance imaging before radical IMRT between 2000 and 2008 were retrospectively reviewed. The patients were classified into 2 groups based on the ENI dose: low ENI when the ENI dose was 46 Gy (n = 446) and high ENI when the ENI doses were 50 to 60 Gy (n = 58)...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28178124/anaplastic-thyroid-carcinoma-and-foscarnet-use-in-a-multitarget-treatment-documented-by-18f-fdg-pet-ct-a-case-report
#17
Elisa Giannetta, Andrea M Isidori, Cosimo Durante, Cira Di Gioia, Flavia Longo, Vincenzo Tombolini, Nadia Bulzonetti, Chiara Graziadio, Riccardo Pofi, Daniele Gianfrilli, Antonella Verrienti, Raffaella Carletti, Sebastiano Filetti, Andrea Lenzi, Alberto Baroli
RATIONALE: The case reported the rapid remission of disease recurrence achieved adding foscarnet, a DNA polymerase inhibitor that interacts with fibroblast growth factor 2, to low molecular weight heparin and sunitinib for the first time in a patient with an anaplastic thyroid cancer (ATC). PATIENT CONCERNS: A 65-year-old woman with a multinodular goiter referred for a rapid enlargement of a nodule. Histological examination revealed an ATC with a little area of papillary thyroid cancer (PTC)...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28178123/spectrum-of-pediatric-tumors-diagnosed-by-fine-needle-aspiration-cytology
#18
Sadegh Shirian, Yahya Daneshbod, Sezaneh Haghpanah, Bijan Khademi, Farshid Noorbakhsh, Amir Ghaemi, Ziba Mosayebi
Pediatric tumors differ markedly from adult tumors in their nature, distribution, and prognosis. In this 10-year retrospective study, we present our experience with fine-needle aspiration (FNA) in pediatric patients 18 years of age and younger and correlate relationship between gender with organ, diagnosis, malignancy, and age. In our study, FNA material of pediatric tumors or masses with 18 years aged and younger were analyzed retrospectively.All FNAs in pediatric patients during this time period were identified and analyzed for age, gender, cytologic diagnosis, and site of aspiration...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28174607/pitx3-dna-methylation-is-an-independent-predictor-of-overall-survival-in-patients-with-head-and-neck-squamous-cell-carcinoma
#19
Verena Sailer, Emily Eva Holmes, Heidrun Gevensleben, Diane Goltz, Freya Dröge, Alina Franzen, Jörn Dietrich, Glen Kristiansen, Friedrich Bootz, Andreas Schröck, Dimo Dietrich
BACKGROUND: Molecular biomarkers assisting risk-group assignment and subsequent treatment stratification are urgently needed for patients with squamous cell cancer of the head and neck region (HNSCC). Aberrant methylation is a frequent event in cancer and, therefore, a promising source for potential biomarkers. Here, the methylation status of the paired-like homeodomain transcription factor 3 (PITX3) was evaluated in HNSCC. METHODS: Using a quantitative real-time PCR, PITX3 methylation was assessed in a cohort of 326 HNSCC patients treated for localized or locally advanced disease (training cohort)...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28168897/risk-of-nodal-metastasis-in-major-salivary-gland-adenoid-cystic-carcinoma
#20
Uchechukwu C Megwalu, Davud Sirjani
Objective To determine the risk of nodal metastasis, examine risk factors for nodal metastasis, and evaluate the impact of nodal metastasis on survival in patients with major salivary gland adenoid cystic carcinoma. Study Design Retrospective cohort study from a large population- based cancer database. Methods Data were extracted from the SEER 18 database (Surveillance, Epidemiology, and End Results) of the National Cancer Institute. The study cohort included 720 patients diagnosed with major salivary gland adenoid cystic carcinoma between 1988 and 2013...
February 1, 2017: Otolaryngology—Head and Neck Surgery
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